-- dump date   	20140619_063054
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
485915000001	XXXCH domain; Region: XXXCH_domain; TIGR04358
485915000002	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
485915000003	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
485915000004	P-loop; other site
485915000005	Magnesium ion binding site [ion binding]; other site
485915000006	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
485915000007	Magnesium ion binding site [ion binding]; other site
485915000008	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
485915000009	ParB-like nuclease domain; Region: ParB; smart00470
485915000010	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
485915000011	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
485915000012	putative ribose interaction site [chemical binding]; other site
485915000013	putative ADP binding site [chemical binding]; other site
485915000014	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
485915000015	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
485915000016	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
485915000017	active site
485915000018	dimer interface [polypeptide binding]; other site
485915000019	effector binding site; other site
485915000020	TSCPD domain; Region: TSCPD; pfam12637
485915000021	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
485915000022	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
485915000023	Walker A/P-loop; other site
485915000024	ATP binding site [chemical binding]; other site
485915000025	Q-loop/lid; other site
485915000026	ABC transporter signature motif; other site
485915000027	Walker B; other site
485915000028	D-loop; other site
485915000029	H-loop/switch region; other site
485915000030	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
485915000031	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
485915000032	Methyltransferase domain; Region: Methyltransf_31; pfam13847
485915000033	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915000034	S-adenosylmethionine binding site [chemical binding]; other site
485915000035	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
485915000036	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
485915000037	dimer interface [polypeptide binding]; other site
485915000038	putative functional site; other site
485915000039	putative MPT binding site; other site
485915000040	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
485915000041	putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494
485915000042	Putative Fe-S cluster; Region: FeS; cl17515
485915000043	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
485915000044	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
485915000045	dimer interface [polypeptide binding]; other site
485915000046	motif 1; other site
485915000047	active site
485915000048	motif 2; other site
485915000049	motif 3; other site
485915000050	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
485915000051	anticodon binding site; other site
485915000052	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
485915000053	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
485915000054	dimer interface [polypeptide binding]; other site
485915000055	anticodon binding site; other site
485915000056	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
485915000057	homodimer interface [polypeptide binding]; other site
485915000058	motif 1; other site
485915000059	active site
485915000060	motif 2; other site
485915000061	GAD domain; Region: GAD; pfam02938
485915000062	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
485915000063	motif 3; other site
485915000064	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
485915000065	active site
485915000066	catalytic residues [active]
485915000067	metal binding site [ion binding]; metal-binding site
485915000068	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
485915000069	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
485915000070	putative active site [active]
485915000071	substrate binding site [chemical binding]; other site
485915000072	putative cosubstrate binding site; other site
485915000073	catalytic site [active]
485915000074	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
485915000075	substrate binding site [chemical binding]; other site
485915000076	Protein of unknown function DUF116; Region: DUF116; pfam01976
485915000077	NusB family; Region: NusB; pfam01029
485915000078	putative RNA binding site [nucleotide binding]; other site
485915000079	16S rRNA methyltransferase B; Provisional; Region: PRK14901
485915000080	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
485915000081	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
485915000082	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
485915000083	heterodimer interface [polypeptide binding]; other site
485915000084	active site
485915000085	FMN binding site [chemical binding]; other site
485915000086	homodimer interface [polypeptide binding]; other site
485915000087	substrate binding site [chemical binding]; other site
485915000088	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
485915000089	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
485915000090	FAD binding pocket [chemical binding]; other site
485915000091	FAD binding motif [chemical binding]; other site
485915000092	phosphate binding motif [ion binding]; other site
485915000093	beta-alpha-beta structure motif; other site
485915000094	NAD binding pocket [chemical binding]; other site
485915000095	Iron coordination center [ion binding]; other site
485915000096	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
485915000097	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
485915000098	Walker A/P-loop; other site
485915000099	ATP binding site [chemical binding]; other site
485915000100	Q-loop/lid; other site
485915000101	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
485915000102	ABC transporter signature motif; other site
485915000103	Walker B; other site
485915000104	D-loop; other site
485915000105	H-loop/switch region; other site
485915000106	Protein of unknown function (DUF3047); Region: DUF3047; pfam11249
485915000107	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
485915000108	poly(A) polymerase; Region: pcnB; TIGR01942
485915000109	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
485915000110	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
485915000111	Zn2+ binding site [ion binding]; other site
485915000112	Mg2+ binding site [ion binding]; other site
485915000113	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
485915000114	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
485915000115	putative metal binding residues [ion binding]; other site
485915000116	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
485915000117	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
485915000118	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
485915000119	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
485915000120	ABC-ATPase subunit  interface; other site
485915000121	dimer interface [polypeptide binding]; other site
485915000122	putative PBP binding regions; other site
485915000123	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
485915000124	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
485915000125	N-terminal plug; other site
485915000126	ligand-binding site [chemical binding]; other site
485915000127	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
485915000128	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
485915000129	cobalamin binding residues [chemical binding]; other site
485915000130	putative BtuC binding residues; other site
485915000131	dimer interface [polypeptide binding]; other site
485915000132	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
485915000133	dimer interface [polypeptide binding]; other site
485915000134	putative PBP binding regions; other site
485915000135	ABC-ATPase subunit  interface; other site
485915000136	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
485915000137	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
485915000138	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
485915000139	Walker A/P-loop; other site
485915000140	ATP binding site [chemical binding]; other site
485915000141	Q-loop/lid; other site
485915000142	ABC transporter signature motif; other site
485915000143	Walker B; other site
485915000144	D-loop; other site
485915000145	H-loop/switch region; other site
485915000146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
485915000147	Major Facilitator Superfamily; Region: MFS_1; pfam07690
485915000148	putative substrate translocation pore; other site
485915000149	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
485915000150	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
485915000151	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
485915000152	active site
485915000153	homodimer interface [polypeptide binding]; other site
485915000154	catalytic site [active]
485915000155	acceptor binding site [chemical binding]; other site
485915000156	trehalose synthase; Region: treS_nterm; TIGR02456
485915000157	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
485915000158	active site
485915000159	catalytic site [active]
485915000160	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
485915000161	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
485915000162	glycogen branching enzyme; Provisional; Region: PRK12313
485915000163	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
485915000164	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
485915000165	active site
485915000166	catalytic site [active]
485915000167	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
485915000168	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
485915000169	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
485915000170	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
485915000171	catalytic site [active]
485915000172	active site
485915000173	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
485915000174	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
485915000175	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
485915000176	active site
485915000177	catalytic site [active]
485915000178	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
485915000179	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
485915000180	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
485915000181	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
485915000182	active site
485915000183	catalytic site [active]
485915000184	4-alpha-glucanotransferase; Provisional; Region: PRK14508
485915000185	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
485915000186	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
485915000187	acyl-activating enzyme (AAE) consensus motif; other site
485915000188	putative AMP binding site [chemical binding]; other site
485915000189	putative active site [active]
485915000190	putative CoA binding site [chemical binding]; other site
485915000191	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
485915000192	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
485915000193	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
485915000194	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
485915000195	active site
485915000196	dimer interface [polypeptide binding]; other site
485915000197	motif 1; other site
485915000198	motif 2; other site
485915000199	motif 3; other site
485915000200	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
485915000201	anticodon binding site; other site
485915000202	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
485915000203	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
485915000204	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
485915000205	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
485915000206	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
485915000207	23S rRNA binding site [nucleotide binding]; other site
485915000208	L21 binding site [polypeptide binding]; other site
485915000209	L13 binding site [polypeptide binding]; other site
485915000210	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
485915000211	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
485915000212	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
485915000213	dimer interface [polypeptide binding]; other site
485915000214	motif 1; other site
485915000215	active site
485915000216	motif 2; other site
485915000217	motif 3; other site
485915000218	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
485915000219	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
485915000220	putative tRNA-binding site [nucleotide binding]; other site
485915000221	B3/4 domain; Region: B3_4; pfam03483
485915000222	tRNA synthetase B5 domain; Region: B5; pfam03484
485915000223	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
485915000224	dimer interface [polypeptide binding]; other site
485915000225	motif 1; other site
485915000226	motif 3; other site
485915000227	motif 2; other site
485915000228	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
485915000229	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
485915000230	Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956
485915000231	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
485915000232	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
485915000233	DNA binding residues [nucleotide binding]
485915000234	PAS domain; Region: PAS_9; pfam13426
485915000235	PAS fold; Region: PAS_4; pfam08448
485915000236	PAS domain S-box; Region: sensory_box; TIGR00229
485915000237	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915000238	putative active site [active]
485915000239	heme pocket [chemical binding]; other site
485915000240	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
485915000241	Transposase; Region: DEDD_Tnp_IS110; pfam01548
485915000242	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
485915000243	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
485915000244	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
485915000245	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
485915000246	putative active site [active]
485915000247	heme pocket [chemical binding]; other site
485915000248	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915000249	putative active site [active]
485915000250	heme pocket [chemical binding]; other site
485915000251	PAS domain; Region: PAS_9; pfam13426
485915000252	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915000253	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915000254	metal binding site [ion binding]; metal-binding site
485915000255	active site
485915000256	I-site; other site
485915000257	FOG: CBS domain [General function prediction only]; Region: COG0517
485915000258	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_24; cd04637
485915000259	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
485915000260	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
485915000261	ligand binding site [chemical binding]; other site
485915000262	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
485915000263	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
485915000264	active site residue [active]
485915000265	Uncharacterized conserved protein [Function unknown]; Region: COG1633
485915000266	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
485915000267	diiron binding motif [ion binding]; other site
485915000268	Transposase; Region: DEDD_Tnp_IS110; pfam01548
485915000269	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
485915000270	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
485915000271	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
485915000272	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
485915000273	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
485915000274	Ferritin-like domain; Region: Ferritin; pfam00210
485915000275	heme binding site [chemical binding]; other site
485915000276	ferroxidase pore; other site
485915000277	ferroxidase diiron center [ion binding]; other site
485915000278	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
485915000279	ATP cone domain; Region: ATP-cone; pfam03477
485915000280	Class III ribonucleotide reductase; Region: RNR_III; cd01675
485915000281	effector binding site; other site
485915000282	active site
485915000283	Zn binding site [ion binding]; other site
485915000284	glycine loop; other site
485915000285	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
485915000286	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915000287	FeS/SAM binding site; other site
485915000288	Cysteine-rich small domain; Region: zf-like; cl00946
485915000289	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
485915000290	DctM-like transporters; Region: DctM; pfam06808
485915000291	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
485915000292	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
485915000293	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
485915000294	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
485915000295	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915000296	Walker A motif; other site
485915000297	ATP binding site [chemical binding]; other site
485915000298	Walker B motif; other site
485915000299	arginine finger; other site
485915000300	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915000301	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
485915000302	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
485915000303	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
485915000304	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
485915000305	ATP binding site [chemical binding]; other site
485915000306	putative Mg++ binding site [ion binding]; other site
485915000307	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
485915000308	nucleotide binding region [chemical binding]; other site
485915000309	ATP-binding site [chemical binding]; other site
485915000310	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
485915000311	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
485915000312	active site
485915000313	catalytic site [active]
485915000314	substrate binding site [chemical binding]; other site
485915000315	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
485915000316	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915000317	active site
485915000318	phosphorylation site [posttranslational modification]
485915000319	intermolecular recognition site; other site
485915000320	dimerization interface [polypeptide binding]; other site
485915000321	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915000322	Walker A motif; other site
485915000323	ATP binding site [chemical binding]; other site
485915000324	Walker B motif; other site
485915000325	arginine finger; other site
485915000326	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915000327	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915000328	dimer interface [polypeptide binding]; other site
485915000329	phosphorylation site [posttranslational modification]
485915000330	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915000331	ATP binding site [chemical binding]; other site
485915000332	Mg2+ binding site [ion binding]; other site
485915000333	G-X-G motif; other site
485915000334	aspartate aminotransferase; Provisional; Region: PRK05764
485915000335	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
485915000336	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915000337	homodimer interface [polypeptide binding]; other site
485915000338	catalytic residue [active]
485915000339	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915000340	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
485915000341	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
485915000342	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790
485915000343	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
485915000344	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
485915000345	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
485915000346	substrate binding pocket [chemical binding]; other site
485915000347	membrane-bound complex binding site; other site
485915000348	hinge residues; other site
485915000349	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915000350	PAS domain; Region: PAS_9; pfam13426
485915000351	putative active site [active]
485915000352	heme pocket [chemical binding]; other site
485915000353	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915000354	PAS fold; Region: PAS_3; pfam08447
485915000355	putative active site [active]
485915000356	heme pocket [chemical binding]; other site
485915000357	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915000358	ATP binding site [chemical binding]; other site
485915000359	Mg2+ binding site [ion binding]; other site
485915000360	G-X-G motif; other site
485915000361	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
485915000362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915000363	active site
485915000364	phosphorylation site [posttranslational modification]
485915000365	intermolecular recognition site; other site
485915000366	dimerization interface [polypeptide binding]; other site
485915000367	DNA topoisomerase I; Validated; Region: PRK06599
485915000368	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
485915000369	active site
485915000370	interdomain interaction site; other site
485915000371	putative metal-binding site [ion binding]; other site
485915000372	nucleotide binding site [chemical binding]; other site
485915000373	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
485915000374	domain I; other site
485915000375	DNA binding groove [nucleotide binding]
485915000376	phosphate binding site [ion binding]; other site
485915000377	domain II; other site
485915000378	domain III; other site
485915000379	nucleotide binding site [chemical binding]; other site
485915000380	catalytic site [active]
485915000381	domain IV; other site
485915000382	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
485915000383	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
485915000384	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
485915000385	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
485915000386	GTPase Era; Reviewed; Region: era; PRK00089
485915000387	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
485915000388	G1 box; other site
485915000389	GTP/Mg2+ binding site [chemical binding]; other site
485915000390	Switch I region; other site
485915000391	G2 box; other site
485915000392	Switch II region; other site
485915000393	G3 box; other site
485915000394	G4 box; other site
485915000395	G5 box; other site
485915000396	KH domain; Region: KH_2; pfam07650
485915000397	G-X-X-G motif; other site
485915000398	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
485915000399	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
485915000400	catalytic residue [active]
485915000401	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
485915000402	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
485915000403	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
485915000404	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
485915000405	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
485915000406	N-acetyl-D-glucosamine binding site [chemical binding]; other site
485915000407	catalytic residue [active]
485915000408	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
485915000409	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
485915000410	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
485915000411	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
485915000412	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
485915000413	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
485915000414	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
485915000415	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
485915000416	shikimate binding site; other site
485915000417	NAD(P) binding site [chemical binding]; other site
485915000418	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
485915000419	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
485915000420	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
485915000421	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
485915000422	TPP-binding site [chemical binding]; other site
485915000423	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
485915000424	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
485915000425	dimer interface [polypeptide binding]; other site
485915000426	PYR/PP interface [polypeptide binding]; other site
485915000427	TPP binding site [chemical binding]; other site
485915000428	substrate binding site [chemical binding]; other site
485915000429	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915000430	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
485915000431	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
485915000432	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
485915000433	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
485915000434	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
485915000435	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
485915000436	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
485915000437	membrane-bound complex binding site; other site
485915000438	hinge residues; other site
485915000439	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
485915000440	HAMP domain; Region: HAMP; pfam00672
485915000441	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915000442	dimer interface [polypeptide binding]; other site
485915000443	phosphorylation site [posttranslational modification]
485915000444	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915000445	ATP binding site [chemical binding]; other site
485915000446	G-X-G motif; other site
485915000447	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
485915000448	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915000449	active site
485915000450	phosphorylation site [posttranslational modification]
485915000451	intermolecular recognition site; other site
485915000452	dimerization interface [polypeptide binding]; other site
485915000453	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915000454	Walker A motif; other site
485915000455	ATP binding site [chemical binding]; other site
485915000456	Walker B motif; other site
485915000457	arginine finger; other site
485915000458	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915000459	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
485915000460	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
485915000461	Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453
485915000462	active site
485915000463	catalytic residues [active]
485915000464	Flagellin N-methylase; Region: FliB; cl00497
485915000465	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
485915000466	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
485915000467	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
485915000468	catalytic residue [active]
485915000469	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
485915000470	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
485915000471	trimerization site [polypeptide binding]; other site
485915000472	active site
485915000473	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
485915000474	NifU-like domain; Region: NifU; pfam01106
485915000475	EamA-like transporter family; Region: EamA; pfam00892
485915000476	DsrE/DsrF-like family; Region: DrsE; cl00672
485915000477	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
485915000478	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
485915000479	MarR family; Region: MarR; pfam01047
485915000480	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
485915000481	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
485915000482	DNA binding residues [nucleotide binding]
485915000483	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
485915000484	HlyD family secretion protein; Region: HlyD_3; pfam13437
485915000485	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
485915000486	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
485915000487	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
485915000488	AsmA family; Region: AsmA; pfam05170
485915000489	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
485915000490	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
485915000491	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
485915000492	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
485915000493	Nitrogen regulatory protein P-II; Region: P-II; smart00938
485915000494	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
485915000495	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
485915000496	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
485915000497	putative active site; other site
485915000498	catalytic residue [active]
485915000499	Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465
485915000500	3-dehydroquinate synthase; Provisional; Region: PRK02290
485915000501	Chorismate mutase type II; Region: CM_2; pfam01817
485915000502	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
485915000503	Prephenate dehydratase; Region: PDT; pfam00800
485915000504	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
485915000505	putative L-Phe binding site [chemical binding]; other site
485915000506	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
485915000507	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
485915000508	hinge; other site
485915000509	active site
485915000510	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
485915000511	prephenate dehydrogenase; Provisional; Region: PRK06444
485915000512	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
485915000513	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
485915000514	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
485915000515	Glutamine amidotransferase class-I; Region: GATase; pfam00117
485915000516	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
485915000517	glutamine binding [chemical binding]; other site
485915000518	catalytic triad [active]
485915000519	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
485915000520	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
485915000521	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
485915000522	active site
485915000523	ribulose/triose binding site [chemical binding]; other site
485915000524	phosphate binding site [ion binding]; other site
485915000525	substrate (anthranilate) binding pocket [chemical binding]; other site
485915000526	product (indole) binding pocket [chemical binding]; other site
485915000527	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
485915000528	active site
485915000529	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
485915000530	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
485915000531	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915000532	catalytic residue [active]
485915000533	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
485915000534	substrate binding site [chemical binding]; other site
485915000535	active site
485915000536	catalytic residues [active]
485915000537	heterodimer interface [polypeptide binding]; other site
485915000538	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
485915000539	Uncharacterized conserved protein [Function unknown]; Region: COG1434
485915000540	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
485915000541	putative active site [active]
485915000542	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
485915000543	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
485915000544	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
485915000545	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
485915000546	tetramerization interface [polypeptide binding]; other site
485915000547	NAD(P) binding site [chemical binding]; other site
485915000548	catalytic residues [active]
485915000549	choline dehydrogenase; Validated; Region: PRK02106
485915000550	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
485915000551	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
485915000552	MarR family; Region: MarR; pfam01047
485915000553	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
485915000554	Protein of unknown function, DUF482; Region: DUF482; pfam04339
485915000555	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
485915000556	active site
485915000557	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
485915000558	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
485915000559	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
485915000560	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
485915000561	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
485915000562	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
485915000563	Rubredoxin [Energy production and conversion]; Region: COG1773
485915000564	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
485915000565	iron binding site [ion binding]; other site
485915000566	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
485915000567	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
485915000568	non-heme iron binding site [ion binding]; other site
485915000569	dimer interface [polypeptide binding]; other site
485915000570	Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171
485915000571	non-heme iron binding site [ion binding]; other site
485915000572	dimer interface [polypeptide binding]; other site
485915000573	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
485915000574	metal binding site 2 [ion binding]; metal-binding site
485915000575	putative DNA binding helix; other site
485915000576	metal binding site 1 [ion binding]; metal-binding site
485915000577	dimer interface [polypeptide binding]; other site
485915000578	structural Zn2+ binding site [ion binding]; other site
485915000579	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
485915000580	AMIN domain; Region: AMIN; pfam11741
485915000581	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
485915000582	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
485915000583	active site
485915000584	metal binding site [ion binding]; metal-binding site
485915000585	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
485915000586	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
485915000587	glutaminase active site [active]
485915000588	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
485915000589	dimer interface [polypeptide binding]; other site
485915000590	active site
485915000591	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
485915000592	dimer interface [polypeptide binding]; other site
485915000593	active site
485915000594	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
485915000595	active site
485915000596	dimerization interface [polypeptide binding]; other site
485915000597	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
485915000598	Mechanosensitive ion channel; Region: MS_channel; pfam00924
485915000599	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
485915000600	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
485915000601	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915000602	FeS/SAM binding site; other site
485915000603	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
485915000604	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
485915000605	RNA binding site [nucleotide binding]; other site
485915000606	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
485915000607	RNA binding site [nucleotide binding]; other site
485915000608	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
485915000609	RNA binding site [nucleotide binding]; other site
485915000610	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
485915000611	RNA binding site [nucleotide binding]; other site
485915000612	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
485915000613	RNA binding site [nucleotide binding]; other site
485915000614	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
485915000615	RNA binding site [nucleotide binding]; other site
485915000616	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
485915000617	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
485915000618	tandem repeat interface [polypeptide binding]; other site
485915000619	oligomer interface [polypeptide binding]; other site
485915000620	active site residues [active]
485915000621	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
485915000622	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
485915000623	FeS/SAM binding site; other site
485915000624	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
485915000625	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
485915000626	putative active site [active]
485915000627	putative NTP binding site [chemical binding]; other site
485915000628	putative nucleic acid binding site [nucleotide binding]; other site
485915000629	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
485915000630	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
485915000631	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
485915000632	substrate binding site; other site
485915000633	tetramer interface; other site
485915000634	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
485915000635	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
485915000636	Putative molybdenum carrier; Region: MoCo_carrier; pfam12694
485915000637	Transcriptional regulators [Transcription]; Region: FadR; COG2186
485915000638	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
485915000639	DNA-binding site [nucleotide binding]; DNA binding site
485915000640	FCD domain; Region: FCD; pfam07729
485915000641	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
485915000642	active site
485915000643	substrate binding site [chemical binding]; other site
485915000644	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
485915000645	FMN binding site [chemical binding]; other site
485915000646	putative catalytic residues [active]
485915000647	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
485915000648	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
485915000649	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
485915000650	Coenzyme A binding pocket [chemical binding]; other site
485915000651	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
485915000652	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
485915000653	active site
485915000654	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
485915000655	active site
485915000656	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
485915000657	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
485915000658	Walker A/P-loop; other site
485915000659	ATP binding site [chemical binding]; other site
485915000660	Q-loop/lid; other site
485915000661	ABC transporter signature motif; other site
485915000662	Walker B; other site
485915000663	D-loop; other site
485915000664	H-loop/switch region; other site
485915000665	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
485915000666	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
485915000667	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
485915000668	TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518
485915000669	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
485915000670	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
485915000671	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
485915000672	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
485915000673	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
485915000674	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915000675	PAS domain; Region: PAS_9; pfam13426
485915000676	putative active site [active]
485915000677	heme pocket [chemical binding]; other site
485915000678	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
485915000679	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915000680	Walker A motif; other site
485915000681	ATP binding site [chemical binding]; other site
485915000682	Walker B motif; other site
485915000683	arginine finger; other site
485915000684	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915000685	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
485915000686	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
485915000687	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
485915000688	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
485915000689	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
485915000690	NAD(P) binding pocket [chemical binding]; other site
485915000691	putative peptidase; Provisional; Region: PRK11649
485915000692	Peptidase family M23; Region: Peptidase_M23; pfam01551
485915000693	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
485915000694	MoaE interaction surface [polypeptide binding]; other site
485915000695	MoeB interaction surface [polypeptide binding]; other site
485915000696	thiocarboxylated glycine; other site
485915000697	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
485915000698	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
485915000699	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
485915000700	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
485915000701	FOG: CBS domain [General function prediction only]; Region: COG0517
485915000702	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
485915000703	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915000704	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915000705	metal binding site [ion binding]; metal-binding site
485915000706	active site
485915000707	I-site; other site
485915000708	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
485915000709	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915000710	dimer interface [polypeptide binding]; other site
485915000711	conserved gate region; other site
485915000712	putative PBP binding loops; other site
485915000713	ABC-ATPase subunit interface; other site
485915000714	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
485915000715	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915000716	dimer interface [polypeptide binding]; other site
485915000717	conserved gate region; other site
485915000718	putative PBP binding loops; other site
485915000719	ABC-ATPase subunit interface; other site
485915000720	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
485915000721	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
485915000722	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
485915000723	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
485915000724	metal ion-dependent adhesion site (MIDAS); other site
485915000725	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
485915000726	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
485915000727	ligand binding site [chemical binding]; other site
485915000728	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
485915000729	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
485915000730	MPT binding site; other site
485915000731	trimer interface [polypeptide binding]; other site
485915000732	PAS domain; Region: PAS_9; pfam13426
485915000733	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915000734	dimer interface [polypeptide binding]; other site
485915000735	phosphorylation site [posttranslational modification]
485915000736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915000737	ATP binding site [chemical binding]; other site
485915000738	Mg2+ binding site [ion binding]; other site
485915000739	G-X-G motif; other site
485915000740	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
485915000741	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
485915000742	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
485915000743	dimerization interface [polypeptide binding]; other site
485915000744	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915000745	dimer interface [polypeptide binding]; other site
485915000746	phosphorylation site [posttranslational modification]
485915000747	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915000748	ATP binding site [chemical binding]; other site
485915000749	Mg2+ binding site [ion binding]; other site
485915000750	G-X-G motif; other site
485915000751	Response regulator receiver domain; Region: Response_reg; pfam00072
485915000752	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915000753	active site
485915000754	phosphorylation site [posttranslational modification]
485915000755	intermolecular recognition site; other site
485915000756	dimerization interface [polypeptide binding]; other site
485915000757	flavoprotein, HI0933 family; Region: TIGR00275
485915000758	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
485915000759	Predicted transcriptional regulator [Transcription]; Region: COG2932
485915000760	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
485915000761	Catalytic site [active]
485915000762	hypothetical protein; Provisional; Region: PRK10279
485915000763	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
485915000764	active site
485915000765	nucleophile elbow; other site
485915000766	Uncharacterized conserved protein [Function unknown]; Region: COG1633
485915000767	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
485915000768	diiron binding motif [ion binding]; other site
485915000769	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
485915000770	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
485915000771	FAD binding pocket [chemical binding]; other site
485915000772	FAD binding motif [chemical binding]; other site
485915000773	phosphate binding motif [ion binding]; other site
485915000774	beta-alpha-beta structure motif; other site
485915000775	NAD binding pocket [chemical binding]; other site
485915000776	Iron coordination center [ion binding]; other site
485915000777	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
485915000778	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
485915000779	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
485915000780	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915000781	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
485915000782	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
485915000783	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
485915000784	4Fe-4S binding domain; Region: Fer4; pfam00037
485915000785	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
485915000786	Cysteine-rich domain; Region: CCG; pfam02754
485915000787	Cysteine-rich domain; Region: CCG; pfam02754
485915000788	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915000789	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
485915000790	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
485915000791	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
485915000792	dimer interface [polypeptide binding]; other site
485915000793	active site
485915000794	metal binding site [ion binding]; metal-binding site
485915000795	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
485915000796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915000797	active site
485915000798	phosphorylation site [posttranslational modification]
485915000799	intermolecular recognition site; other site
485915000800	dimerization interface [polypeptide binding]; other site
485915000801	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915000802	Walker A motif; other site
485915000803	ATP binding site [chemical binding]; other site
485915000804	Walker B motif; other site
485915000805	arginine finger; other site
485915000806	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915000807	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
485915000808	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915000809	dimer interface [polypeptide binding]; other site
485915000810	phosphorylation site [posttranslational modification]
485915000811	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915000812	ATP binding site [chemical binding]; other site
485915000813	Mg2+ binding site [ion binding]; other site
485915000814	G-X-G motif; other site
485915000815	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
485915000816	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
485915000817	active site
485915000818	NAD binding site [chemical binding]; other site
485915000819	metal binding site [ion binding]; metal-binding site
485915000820	NTPase; Region: NTPase_1; cl17478
485915000821	6-phosphofructo-2-kinase; Region: 6PF2K; pfam01591
485915000822	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
485915000823	catalytic core [active]
485915000824	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
485915000825	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
485915000826	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
485915000827	HlyD family secretion protein; Region: HlyD_3; pfam13437
485915000828	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
485915000829	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
485915000830	putative ligand binding pocket/active site [active]
485915000831	putative metal binding site [ion binding]; other site
485915000832	putative GTP cyclohydrolase; Provisional; Region: PRK13674
485915000833	nickel responsive regulator; Provisional; Region: PRK04460
485915000834	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
485915000835	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
485915000836	Predicted methyltransferase [General function prediction only]; Region: COG3897
485915000837	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915000838	S-adenosylmethionine binding site [chemical binding]; other site
485915000839	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
485915000840	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
485915000841	Walker A/P-loop; other site
485915000842	ATP binding site [chemical binding]; other site
485915000843	Q-loop/lid; other site
485915000844	ABC transporter signature motif; other site
485915000845	Walker B; other site
485915000846	D-loop; other site
485915000847	H-loop/switch region; other site
485915000848	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
485915000849	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
485915000850	active site
485915000851	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
485915000852	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
485915000853	TM-ABC transporter signature motif; other site
485915000854	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
485915000855	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
485915000856	TM-ABC transporter signature motif; other site
485915000857	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
485915000858	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
485915000859	putative ligand binding site [chemical binding]; other site
485915000860	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
485915000861	homodimer interaction site [polypeptide binding]; other site
485915000862	cofactor binding site; other site
485915000863	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
485915000864	active site
485915000865	intersubunit interface [polypeptide binding]; other site
485915000866	Zn2+ binding site [ion binding]; other site
485915000867	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14184
485915000868	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
485915000869	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
485915000870	homodimer interface [polypeptide binding]; other site
485915000871	NADP binding site [chemical binding]; other site
485915000872	substrate binding site [chemical binding]; other site
485915000873	AIR carboxylase; Region: AIRC; pfam00731
485915000874	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
485915000875	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
485915000876	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
485915000877	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
485915000878	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
485915000879	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
485915000880	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
485915000881	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
485915000882	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
485915000883	active site
485915000884	Zn binding site [ion binding]; other site
485915000885	TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518
485915000886	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
485915000887	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
485915000888	[4Fe-4S] binding site [ion binding]; other site
485915000889	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
485915000890	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
485915000891	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
485915000892	molybdopterin cofactor binding site; other site
485915000893	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
485915000894	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
485915000895	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
485915000896	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
485915000897	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915000898	putative active site [active]
485915000899	heme pocket [chemical binding]; other site
485915000900	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915000901	dimer interface [polypeptide binding]; other site
485915000902	phosphorylation site [posttranslational modification]
485915000903	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915000904	ATP binding site [chemical binding]; other site
485915000905	Mg2+ binding site [ion binding]; other site
485915000906	G-X-G motif; other site
485915000907	Response regulator receiver domain; Region: Response_reg; pfam00072
485915000908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915000909	active site
485915000910	phosphorylation site [posttranslational modification]
485915000911	intermolecular recognition site; other site
485915000912	dimerization interface [polypeptide binding]; other site
485915000913	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
485915000914	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
485915000915	active site
485915000916	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
485915000917	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
485915000918	active site
485915000919	FMN binding site [chemical binding]; other site
485915000920	substrate binding site [chemical binding]; other site
485915000921	3Fe-4S cluster binding site [ion binding]; other site
485915000922	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
485915000923	domain_subunit interface; other site
485915000924	Peptidase family M48; Region: Peptidase_M48; cl12018
485915000925	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
485915000926	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
485915000927	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
485915000928	Cysteine-rich domain; Region: CCG; pfam02754
485915000929	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
485915000930	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
485915000931	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
485915000932	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
485915000933	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
485915000934	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915000935	TPR motif; other site
485915000936	TPR repeat; Region: TPR_11; pfam13414
485915000937	binding surface
485915000938	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915000939	binding surface
485915000940	TPR motif; other site
485915000941	Tetratricopeptide repeat; Region: TPR_16; pfam13432
485915000942	Tetratricopeptide repeat; Region: TPR_12; pfam13424
485915000943	sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064
485915000944	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
485915000945	sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066
485915000946	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
485915000947	Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679
485915000948	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
485915000949	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
485915000950	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
485915000951	catalytic triad [active]
485915000952	Flagellin N-methylase; Region: FliB; pfam03692
485915000953	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
485915000954	conserved cys residue [active]
485915000955	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
485915000956	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
485915000957	HIGH motif; other site
485915000958	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
485915000959	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
485915000960	active site
485915000961	KMSKS motif; other site
485915000962	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
485915000963	tRNA binding surface [nucleotide binding]; other site
485915000964	anticodon binding site; other site
485915000965	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
485915000966	homodimer interface [polypeptide binding]; other site
485915000967	active site
485915000968	SAM binding site [chemical binding]; other site
485915000969	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
485915000970	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
485915000971	active site
485915000972	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
485915000973	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
485915000974	active site
485915000975	substrate binding site [chemical binding]; other site
485915000976	cosubstrate binding site; other site
485915000977	catalytic site [active]
485915000978	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
485915000979	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
485915000980	DNA binding site [nucleotide binding]
485915000981	catalytic residue [active]
485915000982	H2TH interface [polypeptide binding]; other site
485915000983	putative catalytic residues [active]
485915000984	turnover-facilitating residue; other site
485915000985	intercalation triad [nucleotide binding]; other site
485915000986	8OG recognition residue [nucleotide binding]; other site
485915000987	putative reading head residues; other site
485915000988	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
485915000989	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
485915000990	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
485915000991	active site
485915000992	Methyltransferase domain; Region: Methyltransf_23; pfam13489
485915000993	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915000994	S-adenosylmethionine binding site [chemical binding]; other site
485915000995	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
485915000996	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
485915000997	motif II; other site
485915000998	Domain of unknown function DUF20; Region: UPF0118; pfam01594
485915000999	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
485915001000	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
485915001001	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
485915001002	Protein of unknown function (DUF493); Region: DUF493; pfam04359
485915001003	Isochorismatase family; Region: Isochorismatase; pfam00857
485915001004	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
485915001005	catalytic triad [active]
485915001006	conserved cis-peptide bond; other site
485915001007	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
485915001008	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
485915001009	phosphoserine phosphatase SerB; Region: serB; TIGR00338
485915001010	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
485915001011	motif II; other site
485915001012	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
485915001013	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
485915001014	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
485915001015	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
485915001016	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
485915001017	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
485915001018	putative substrate-binding site; other site
485915001019	nickel binding site [ion binding]; other site
485915001020	HupF/HypC family; Region: HupF_HypC; pfam01455
485915001021	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
485915001022	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
485915001023	Substrate binding site; other site
485915001024	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
485915001025	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
485915001026	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
485915001027	molybdopterin cofactor binding site; other site
485915001028	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
485915001029	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
485915001030	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
485915001031	4Fe-4S binding domain; Region: Fer4; cl02805
485915001032	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915001033	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
485915001034	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
485915001035	Predicted permease; Region: DUF318; cl17795
485915001036	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
485915001037	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
485915001038	EamA-like transporter family; Region: EamA; pfam00892
485915001039	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
485915001040	EamA-like transporter family; Region: EamA; pfam00892
485915001041	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
485915001042	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
485915001043	GTP binding site; other site
485915001044	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
485915001045	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
485915001046	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
485915001047	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
485915001048	inhibitor-cofactor binding pocket; inhibition site
485915001049	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915001050	catalytic residue [active]
485915001051	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
485915001052	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
485915001053	putative active site [active]
485915001054	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
485915001055	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
485915001056	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
485915001057	ATP binding site [chemical binding]; other site
485915001058	putative Mg++ binding site [ion binding]; other site
485915001059	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
485915001060	nucleotide binding region [chemical binding]; other site
485915001061	ATP-binding site [chemical binding]; other site
485915001062	Transposase IS200 like; Region: Y1_Tnp; cl00848
485915001063	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
485915001064	O-Antigen ligase; Region: Wzy_C; pfam04932
485915001065	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
485915001066	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
485915001067	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
485915001068	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
485915001069	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
485915001070	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
485915001071	Walker A/P-loop; other site
485915001072	ATP binding site [chemical binding]; other site
485915001073	Q-loop/lid; other site
485915001074	ABC transporter signature motif; other site
485915001075	Walker B; other site
485915001076	D-loop; other site
485915001077	H-loop/switch region; other site
485915001078	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
485915001079	putative active site [active]
485915001080	putative metal binding site [ion binding]; other site
485915001081	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
485915001082	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
485915001083	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
485915001084	DHH family; Region: DHH; pfam01368
485915001085	DHHA1 domain; Region: DHHA1; pfam02272
485915001086	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
485915001087	active site
485915001088	dimer interface [polypeptide binding]; other site
485915001089	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
485915001090	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
485915001091	catalytic site [active]
485915001092	G-X2-G-X-G-K; other site
485915001093	hypothetical protein; Provisional; Region: PRK04323
485915001094	hypothetical protein; Provisional; Region: PRK11820
485915001095	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
485915001096	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
485915001097	Domain of unknown function (DUF4416); Region: DUF4416; pfam14385
485915001098	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
485915001099	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
485915001100	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
485915001101	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
485915001102	Ligand Binding Site [chemical binding]; other site
485915001103	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
485915001104	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
485915001105	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
485915001106	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
485915001107	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
485915001108	putative ligand binding site [chemical binding]; other site
485915001109	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
485915001110	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
485915001111	nucleotide binding site [chemical binding]; other site
485915001112	NEF interaction site [polypeptide binding]; other site
485915001113	SBD interface [polypeptide binding]; other site
485915001114	GrpE; Region: GrpE; pfam01025
485915001115	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
485915001116	dimer interface [polypeptide binding]; other site
485915001117	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
485915001118	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
485915001119	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
485915001120	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
485915001121	NADP binding site [chemical binding]; other site
485915001122	active site
485915001123	putative substrate binding site [chemical binding]; other site
485915001124	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
485915001125	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
485915001126	NAD binding site [chemical binding]; other site
485915001127	substrate binding site [chemical binding]; other site
485915001128	homodimer interface [polypeptide binding]; other site
485915001129	active site
485915001130	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
485915001131	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
485915001132	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
485915001133	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
485915001134	Ligand Binding Site [chemical binding]; other site
485915001135	recombinase A; Provisional; Region: recA; PRK09354
485915001136	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
485915001137	hexamer interface [polypeptide binding]; other site
485915001138	Walker A motif; other site
485915001139	ATP binding site [chemical binding]; other site
485915001140	Walker B motif; other site
485915001141	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
485915001142	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
485915001143	motif 1; other site
485915001144	active site
485915001145	motif 2; other site
485915001146	motif 3; other site
485915001147	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
485915001148	DHHA1 domain; Region: DHHA1; pfam02272
485915001149	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
485915001150	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
485915001151	FAD binding pocket [chemical binding]; other site
485915001152	FAD binding motif [chemical binding]; other site
485915001153	phosphate binding motif [ion binding]; other site
485915001154	beta-alpha-beta structure motif; other site
485915001155	NAD binding pocket [chemical binding]; other site
485915001156	Iron coordination center [ion binding]; other site
485915001157	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
485915001158	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
485915001159	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
485915001160	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
485915001161	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
485915001162	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
485915001163	active site
485915001164	HIGH motif; other site
485915001165	KMSKS motif; other site
485915001166	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
485915001167	tRNA binding surface [nucleotide binding]; other site
485915001168	anticodon binding site; other site
485915001169	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
485915001170	dimer interface [polypeptide binding]; other site
485915001171	putative tRNA-binding site [nucleotide binding]; other site
485915001172	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
485915001173	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
485915001174	G1 box; other site
485915001175	GTP/Mg2+ binding site [chemical binding]; other site
485915001176	Switch I region; other site
485915001177	G2 box; other site
485915001178	G3 box; other site
485915001179	Switch II region; other site
485915001180	G4 box; other site
485915001181	G5 box; other site
485915001182	Nucleoside recognition; Region: Gate; pfam07670
485915001183	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
485915001184	Nucleoside recognition; Region: Gate; pfam07670
485915001185	FeoA domain; Region: FeoA; pfam04023
485915001186	FeoA domain; Region: FeoA; pfam04023
485915001187	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
485915001188	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
485915001189	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
485915001190	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
485915001191	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
485915001192	ATP-grasp domain; Region: ATP-grasp_4; cl17255
485915001193	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
485915001194	IMP binding site; other site
485915001195	dimer interface [polypeptide binding]; other site
485915001196	partial ornithine binding site; other site
485915001197	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
485915001198	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
485915001199	active site
485915001200	tetramer interface [polypeptide binding]; other site
485915001201	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
485915001202	active site
485915001203	KpsF/GutQ family protein; Region: kpsF; TIGR00393
485915001204	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
485915001205	putative active site [active]
485915001206	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
485915001207	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
485915001208	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
485915001209	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
485915001210	Transglycosylase; Region: Transgly; pfam00912
485915001211	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
485915001212	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
485915001213	Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187
485915001214	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
485915001215	Peptidase family U32; Region: Peptidase_U32; pfam01136
485915001216	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
485915001217	CoenzymeA binding site [chemical binding]; other site
485915001218	subunit interaction site [polypeptide binding]; other site
485915001219	PHB binding site; other site
485915001220	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
485915001221	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915001222	S-adenosylmethionine binding site [chemical binding]; other site
485915001223	PAS fold; Region: PAS_4; pfam08448
485915001224	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915001225	putative active site [active]
485915001226	heme pocket [chemical binding]; other site
485915001227	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915001228	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915001229	metal binding site [ion binding]; metal-binding site
485915001230	active site
485915001231	I-site; other site
485915001232	malate synthase G; Provisional; Region: PRK02999
485915001233	active site
485915001234	Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
485915001235	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
485915001236	hypothetical protein; Reviewed; Region: PRK09588
485915001237	Protein of unknown function (DUF972); Region: DUF972; pfam06156
485915001238	RNA pol II promoter Fmp27 protein domain; Region: Fmp27_WPPW; pfam10359
485915001239	Entericidin EcnA/B family; Region: Entericidin; pfam08085
485915001240	Domain of unknown function (DUF4213); Region: DUF4213; pfam13938
485915001241	Domain of unknown function (DUF364); Region: DUF364; pfam04016
485915001242	GAF domain; Region: GAF_2; pfam13185
485915001243	GAF domain; Region: GAF; pfam01590
485915001244	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
485915001245	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
485915001246	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
485915001247	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
485915001248	Transposase; Region: DDE_Tnp_ISL3; pfam01610
485915001249	Cache domain; Region: Cache_1; pfam02743
485915001250	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
485915001251	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
485915001252	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
485915001253	dimer interface [polypeptide binding]; other site
485915001254	putative CheW interface [polypeptide binding]; other site
485915001255	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
485915001256	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
485915001257	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
485915001258	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
485915001259	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
485915001260	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
485915001261	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
485915001262	active site
485915001263	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
485915001264	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
485915001265	conserved cys residue [active]
485915001266	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
485915001267	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
485915001268	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
485915001269	EamA-like transporter family; Region: EamA; cl17759
485915001270	EamA-like transporter family; Region: EamA; pfam00892
485915001271	putative mechanosensitive channel protein; Provisional; Region: PRK11465
485915001272	Mechanosensitive ion channel; Region: MS_channel; pfam00924
485915001273	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915001274	S-adenosylmethionine binding site [chemical binding]; other site
485915001275	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
485915001276	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
485915001277	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
485915001278	FeS/SAM binding site; other site
485915001279	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
485915001280	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
485915001281	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
485915001282	active site
485915001283	Transcriptional regulator [Transcription]; Region: LysR; COG0583
485915001284	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
485915001285	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
485915001286	dimerization interface [polypeptide binding]; other site
485915001287	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
485915001288	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
485915001289	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
485915001290	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
485915001291	RNA binding site [nucleotide binding]; other site
485915001292	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
485915001293	Chain length determinant protein; Region: Wzz; cl15801
485915001294	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
485915001295	EPS-associated transcriptional regulator, MarR family; Region: MarR_EPS; TIGR04176
485915001296	putative DNA binding site [nucleotide binding]; other site
485915001297	putative Zn2+ binding site [ion binding]; other site
485915001298	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
485915001299	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
485915001300	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
485915001301	active site
485915001302	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
485915001303	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
485915001304	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
485915001305	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
485915001306	Substrate binding site; other site
485915001307	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
485915001308	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
485915001309	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
485915001310	NAD binding site [chemical binding]; other site
485915001311	putative substrate binding site 2 [chemical binding]; other site
485915001312	putative substrate binding site 1 [chemical binding]; other site
485915001313	active site
485915001314	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
485915001315	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
485915001316	Transposase; Region: DDE_Tnp_ISL3; pfam01610
485915001317	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
485915001318	Helix-turn-helix domain; Region: HTH_28; pfam13518
485915001319	putative transposase OrfB; Reviewed; Region: PHA02517
485915001320	Homeodomain-like domain; Region: HTH_32; pfam13565
485915001321	Integrase core domain; Region: rve; pfam00665
485915001322	Integrase core domain; Region: rve_3; pfam13683
485915001323	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
485915001324	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
485915001325	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
485915001326	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
485915001327	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
485915001328	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
485915001329	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
485915001330	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
485915001331	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
485915001332	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
485915001333	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
485915001334	Domain of unknown function (DUF362); Region: DUF362; pfam04015
485915001335	Uncharacterized conserved protein [Function unknown]; Region: COG2006
485915001336	Uncharacterized conserved protein [Function unknown]; Region: COG2006
485915001337	Domain of unknown function (DUF362); Region: DUF362; pfam04015
485915001338	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
485915001339	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
485915001340	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
485915001341	CoA binding site [chemical binding]; other site
485915001342	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
485915001343	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
485915001344	putative NAD(P) binding site [chemical binding]; other site
485915001345	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
485915001346	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
485915001347	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
485915001348	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
485915001349	non-specific DNA binding site [nucleotide binding]; other site
485915001350	salt bridge; other site
485915001351	sequence-specific DNA binding site [nucleotide binding]; other site
485915001352	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
485915001353	SecA binding site; other site
485915001354	Preprotein binding site; other site
485915001355	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
485915001356	putative glycosyl transferase; Provisional; Region: PRK10307
485915001357	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
485915001358	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
485915001359	active site
485915001360	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
485915001361	homodimer interface [polypeptide binding]; other site
485915001362	Transposase IS200 like; Region: Y1_Tnp; cl00848
485915001363	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
485915001364	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
485915001365	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
485915001366	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
485915001367	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
485915001368	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
485915001369	Mg++ binding site [ion binding]; other site
485915001370	putative catalytic motif [active]
485915001371	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
485915001372	phosphate binding site [ion binding]; other site
485915001373	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
485915001374	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_5; cd13145
485915001375	putative efflux protein, MATE family; Region: matE; TIGR00797
485915001376	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
485915001377	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
485915001378	active site
485915001379	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
485915001380	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
485915001381	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
485915001382	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
485915001383	dimerization interface [polypeptide binding]; other site
485915001384	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
485915001385	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915001386	putative active site [active]
485915001387	heme pocket [chemical binding]; other site
485915001388	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915001389	dimer interface [polypeptide binding]; other site
485915001390	phosphorylation site [posttranslational modification]
485915001391	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915001392	ATP binding site [chemical binding]; other site
485915001393	Mg2+ binding site [ion binding]; other site
485915001394	G-X-G motif; other site
485915001395	Response regulator receiver domain; Region: Response_reg; pfam00072
485915001396	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915001397	active site
485915001398	phosphorylation site [posttranslational modification]
485915001399	intermolecular recognition site; other site
485915001400	dimerization interface [polypeptide binding]; other site
485915001401	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
485915001402	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
485915001403	Glucose inhibited division protein A; Region: GIDA; pfam01134
485915001404	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
485915001405	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
485915001406	putative metal binding site; other site
485915001407	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
485915001408	heme-binding residues [chemical binding]; other site
485915001409	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
485915001410	Cysteine-rich domain; Region: CCG; pfam02754
485915001411	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
485915001412	Ligand Binding Site [chemical binding]; other site
485915001413	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
485915001414	Ligand Binding Site [chemical binding]; other site
485915001415	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
485915001416	Cysteine-rich domain; Region: CCG; pfam02754
485915001417	Cysteine-rich domain; Region: CCG; pfam02754
485915001418	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915001419	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
485915001420	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
485915001421	4Fe-4S binding domain; Region: Fer4; pfam00037
485915001422	Response regulator receiver domain; Region: Response_reg; pfam00072
485915001423	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
485915001424	active site
485915001425	phosphorylation site [posttranslational modification]
485915001426	intermolecular recognition site; other site
485915001427	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
485915001428	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
485915001429	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
485915001430	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
485915001431	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
485915001432	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915001433	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
485915001434	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
485915001435	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
485915001436	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
485915001437	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
485915001438	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915001439	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
485915001440	putative active site [active]
485915001441	heme pocket [chemical binding]; other site
485915001442	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915001443	putative active site [active]
485915001444	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
485915001445	heme pocket [chemical binding]; other site
485915001446	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915001447	dimer interface [polypeptide binding]; other site
485915001448	phosphorylation site [posttranslational modification]
485915001449	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915001450	ATP binding site [chemical binding]; other site
485915001451	Mg2+ binding site [ion binding]; other site
485915001452	G-X-G motif; other site
485915001453	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
485915001454	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915001455	active site
485915001456	phosphorylation site [posttranslational modification]
485915001457	intermolecular recognition site; other site
485915001458	dimerization interface [polypeptide binding]; other site
485915001459	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915001460	Walker A motif; other site
485915001461	ATP binding site [chemical binding]; other site
485915001462	Walker B motif; other site
485915001463	arginine finger; other site
485915001464	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
485915001465	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
485915001466	Nucleopolyhedrovirus late expression factor 3 (LEF-3); Region: Baculo_LEF-3; pfam05847
485915001467	NAD synthetase; Provisional; Region: PRK13981
485915001468	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
485915001469	multimer interface [polypeptide binding]; other site
485915001470	active site
485915001471	catalytic triad [active]
485915001472	protein interface 1 [polypeptide binding]; other site
485915001473	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
485915001474	homodimer interface [polypeptide binding]; other site
485915001475	NAD binding pocket [chemical binding]; other site
485915001476	ATP binding pocket [chemical binding]; other site
485915001477	Mg binding site [ion binding]; other site
485915001478	active-site loop [active]
485915001479	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
485915001480	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
485915001481	Domain of unknown function DUF77; Region: DUF77; pfam01910
485915001482	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
485915001483	Major Facilitator Superfamily; Region: MFS_1; pfam07690
485915001484	putative substrate translocation pore; other site
485915001485	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
485915001486	Family of unknown function (DUF490); Region: DUF490; pfam04357
485915001487	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
485915001488	Surface antigen; Region: Bac_surface_Ag; pfam01103
485915001489	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
485915001490	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
485915001491	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
485915001492	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
485915001493	motif II; other site
485915001494	CHASE4 domain; Region: CHASE4; cl01308
485915001495	PAS domain S-box; Region: sensory_box; TIGR00229
485915001496	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915001497	putative active site [active]
485915001498	heme pocket [chemical binding]; other site
485915001499	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915001500	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915001501	metal binding site [ion binding]; metal-binding site
485915001502	active site
485915001503	I-site; other site
485915001504	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
485915001505	active site
485915001506	isocitrate dehydrogenase; Validated; Region: PRK06451
485915001507	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
485915001508	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
485915001509	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
485915001510	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
485915001511	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
485915001512	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
485915001513	P loop nucleotide binding; other site
485915001514	switch II; other site
485915001515	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
485915001516	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
485915001517	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
485915001518	P loop nucleotide binding; other site
485915001519	switch II; other site
485915001520	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
485915001521	Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579
485915001522	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915001523	PAS domain; Region: PAS_9; pfam13426
485915001524	putative active site [active]
485915001525	heme pocket [chemical binding]; other site
485915001526	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
485915001527	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915001528	Walker A motif; other site
485915001529	ATP binding site [chemical binding]; other site
485915001530	Walker B motif; other site
485915001531	arginine finger; other site
485915001532	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
485915001533	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
485915001534	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
485915001535	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
485915001536	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
485915001537	enolase; Provisional; Region: eno; PRK00077
485915001538	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
485915001539	dimer interface [polypeptide binding]; other site
485915001540	metal binding site [ion binding]; metal-binding site
485915001541	substrate binding pocket [chemical binding]; other site
485915001542	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
485915001543	nucleotide binding site [chemical binding]; other site
485915001544	Type III pantothenate kinase; Region: Pan_kinase; cl17198
485915001545	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
485915001546	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
485915001547	Cytochrome c; Region: Cytochrom_C; pfam00034
485915001548	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
485915001549	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
485915001550	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915001551	FeS/SAM binding site; other site
485915001552	HemN C-terminal domain; Region: HemN_C; pfam06969
485915001553	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
485915001554	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
485915001555	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
485915001556	homodimer interface [polypeptide binding]; other site
485915001557	oligonucleotide binding site [chemical binding]; other site
485915001558	Radical SAM superfamily; Region: Radical_SAM; pfam04055
485915001559	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915001560	FeS/SAM binding site; other site
485915001561	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
485915001562	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
485915001563	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
485915001564	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
485915001565	acyl-activating enzyme (AAE) consensus motif; other site
485915001566	active site
485915001567	AMP binding site [chemical binding]; other site
485915001568	CoA binding site [chemical binding]; other site
485915001569	Protein of unknown function, DUF399; Region: DUF399; pfam04187
485915001570	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
485915001571	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
485915001572	AMMECR1; Region: AMMECR1; pfam01871
485915001573	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
485915001574	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
485915001575	PBP superfamily domain; Region: PBP_like_2; cl17296
485915001576	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
485915001577	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
485915001578	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915001579	dimer interface [polypeptide binding]; other site
485915001580	conserved gate region; other site
485915001581	putative PBP binding loops; other site
485915001582	ABC-ATPase subunit interface; other site
485915001583	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
485915001584	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
485915001585	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915001586	dimer interface [polypeptide binding]; other site
485915001587	conserved gate region; other site
485915001588	putative PBP binding loops; other site
485915001589	ABC-ATPase subunit interface; other site
485915001590	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
485915001591	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915001592	active site
485915001593	phosphorylation site [posttranslational modification]
485915001594	intermolecular recognition site; other site
485915001595	dimerization interface [polypeptide binding]; other site
485915001596	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
485915001597	DNA binding site [nucleotide binding]
485915001598	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
485915001599	dimerization interface [polypeptide binding]; other site
485915001600	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
485915001601	PAS domain; Region: PAS; smart00091
485915001602	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915001603	dimer interface [polypeptide binding]; other site
485915001604	phosphorylation site [posttranslational modification]
485915001605	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915001606	ATP binding site [chemical binding]; other site
485915001607	Mg2+ binding site [ion binding]; other site
485915001608	G-X-G motif; other site
485915001609	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
485915001610	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
485915001611	Walker A/P-loop; other site
485915001612	ATP binding site [chemical binding]; other site
485915001613	Q-loop/lid; other site
485915001614	ABC transporter signature motif; other site
485915001615	Walker B; other site
485915001616	D-loop; other site
485915001617	H-loop/switch region; other site
485915001618	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
485915001619	PhoU domain; Region: PhoU; pfam01895
485915001620	PhoU domain; Region: PhoU; pfam01895
485915001621	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
485915001622	MgtE intracellular N domain; Region: MgtE_N; smart00924
485915001623	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
485915001624	Divalent cation transporter; Region: MgtE; pfam01769
485915001625	amphi-Trp domain; Region: amphi-Trp; TIGR04354
485915001626	XXXCH domain; Region: XXXCH_domain; TIGR04358
485915001627	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
485915001628	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915001629	S-adenosylmethionine binding site [chemical binding]; other site
485915001630	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915001631	dimer interface [polypeptide binding]; other site
485915001632	conserved gate region; other site
485915001633	putative PBP binding loops; other site
485915001634	ABC-ATPase subunit interface; other site
485915001635	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
485915001636	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
485915001637	Walker A/P-loop; other site
485915001638	ATP binding site [chemical binding]; other site
485915001639	Q-loop/lid; other site
485915001640	ABC transporter signature motif; other site
485915001641	Walker B; other site
485915001642	D-loop; other site
485915001643	H-loop/switch region; other site
485915001644	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
485915001645	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
485915001646	substrate binding pocket [chemical binding]; other site
485915001647	membrane-bound complex binding site; other site
485915001648	hinge residues; other site
485915001649	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915001650	dimer interface [polypeptide binding]; other site
485915001651	conserved gate region; other site
485915001652	putative PBP binding loops; other site
485915001653	ABC-ATPase subunit interface; other site
485915001654	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
485915001655	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
485915001656	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
485915001657	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
485915001658	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
485915001659	putative dimer interface [polypeptide binding]; other site
485915001660	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
485915001661	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
485915001662	active site
485915001663	putative substrate binding pocket [chemical binding]; other site
485915001664	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
485915001665	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
485915001666	FMN binding site [chemical binding]; other site
485915001667	active site
485915001668	catalytic residues [active]
485915001669	substrate binding site [chemical binding]; other site
485915001670	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
485915001671	RNA/DNA hybrid binding site [nucleotide binding]; other site
485915001672	active site
485915001673	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
485915001674	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
485915001675	active site
485915001676	substrate binding site [chemical binding]; other site
485915001677	metal binding site [ion binding]; metal-binding site
485915001678	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
485915001679	HflK protein; Region: hflK; TIGR01933
485915001680	HflC protein; Region: hflC; TIGR01932
485915001681	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
485915001682	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
485915001683	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
485915001684	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
485915001685	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
485915001686	RNase E interface [polypeptide binding]; other site
485915001687	trimer interface [polypeptide binding]; other site
485915001688	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
485915001689	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
485915001690	RNase E interface [polypeptide binding]; other site
485915001691	trimer interface [polypeptide binding]; other site
485915001692	active site
485915001693	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
485915001694	putative nucleic acid binding region [nucleotide binding]; other site
485915001695	G-X-X-G motif; other site
485915001696	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
485915001697	RNA binding site [nucleotide binding]; other site
485915001698	domain interface; other site
485915001699	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
485915001700	16S/18S rRNA binding site [nucleotide binding]; other site
485915001701	S13e-L30e interaction site [polypeptide binding]; other site
485915001702	25S rRNA binding site [nucleotide binding]; other site
485915001703	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
485915001704	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
485915001705	RNA binding site [nucleotide binding]; other site
485915001706	active site
485915001707	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
485915001708	DHH family; Region: DHH; pfam01368
485915001709	DHHA1 domain; Region: DHHA1; pfam02272
485915001710	Ribosome-binding factor A; Region: RBFA; pfam02033
485915001711	Protein of unknown function (DUF503); Region: DUF503; pfam04456
485915001712	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
485915001713	translation initiation factor IF-2; Region: IF-2; TIGR00487
485915001714	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
485915001715	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
485915001716	G1 box; other site
485915001717	putative GEF interaction site [polypeptide binding]; other site
485915001718	GTP/Mg2+ binding site [chemical binding]; other site
485915001719	Switch I region; other site
485915001720	G2 box; other site
485915001721	G3 box; other site
485915001722	Switch II region; other site
485915001723	G4 box; other site
485915001724	G5 box; other site
485915001725	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
485915001726	Translation-initiation factor 2; Region: IF-2; pfam11987
485915001727	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
485915001728	Protein of unknown function (DUF448); Region: DUF448; pfam04296
485915001729	putative RNA binding cleft [nucleotide binding]; other site
485915001730	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
485915001731	NusA N-terminal domain; Region: NusA_N; pfam08529
485915001732	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
485915001733	RNA binding site [nucleotide binding]; other site
485915001734	homodimer interface [polypeptide binding]; other site
485915001735	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
485915001736	G-X-X-G motif; other site
485915001737	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
485915001738	G-X-X-G motif; other site
485915001739	ribosome maturation protein RimP; Reviewed; Region: PRK00092
485915001740	Sm and related proteins; Region: Sm_like; cl00259
485915001741	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
485915001742	putative oligomer interface [polypeptide binding]; other site
485915001743	putative RNA binding site [nucleotide binding]; other site
485915001744	ATP-NAD kinase; Region: NAD_kinase; pfam01513
485915001745	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
485915001746	Protein of unknown function DUF89; Region: DUF89; cl15397
485915001747	MltA specific insert domain; Region: MltA; smart00925
485915001748	3D domain; Region: 3D; pfam06725
485915001749	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
485915001750	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
485915001751	GatB domain; Region: GatB_Yqey; smart00845
485915001752	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
485915001753	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
485915001754	GTP-binding protein Der; Reviewed; Region: PRK00093
485915001755	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
485915001756	G1 box; other site
485915001757	GTP/Mg2+ binding site [chemical binding]; other site
485915001758	Switch I region; other site
485915001759	G2 box; other site
485915001760	Switch II region; other site
485915001761	G3 box; other site
485915001762	G4 box; other site
485915001763	G5 box; other site
485915001764	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
485915001765	G1 box; other site
485915001766	GTP/Mg2+ binding site [chemical binding]; other site
485915001767	Switch I region; other site
485915001768	G2 box; other site
485915001769	G3 box; other site
485915001770	Switch II region; other site
485915001771	G4 box; other site
485915001772	G5 box; other site
485915001773	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
485915001774	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
485915001775	homodimer interface [polypeptide binding]; other site
485915001776	substrate-cofactor binding pocket; other site
485915001777	catalytic residue [active]
485915001778	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
485915001779	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915001780	Walker A motif; other site
485915001781	ATP binding site [chemical binding]; other site
485915001782	Walker B motif; other site
485915001783	arginine finger; other site
485915001784	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
485915001785	hypothetical protein; Validated; Region: PRK00153
485915001786	recombination protein RecR; Reviewed; Region: recR; PRK00076
485915001787	RecR protein; Region: RecR; pfam02132
485915001788	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
485915001789	putative active site [active]
485915001790	putative metal-binding site [ion binding]; other site
485915001791	tetramer interface [polypeptide binding]; other site
485915001792	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
485915001793	AAA domain; Region: AAA_30; pfam13604
485915001794	Family description; Region: UvrD_C_2; pfam13538
485915001795	trigger factor; Provisional; Region: tig; PRK01490
485915001796	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
485915001797	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
485915001798	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
485915001799	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
485915001800	oligomer interface [polypeptide binding]; other site
485915001801	active site residues [active]
485915001802	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
485915001803	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
485915001804	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915001805	Walker A motif; other site
485915001806	ATP binding site [chemical binding]; other site
485915001807	Walker B motif; other site
485915001808	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
485915001809	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
485915001810	Found in ATP-dependent protease La (LON); Region: LON; smart00464
485915001811	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915001812	Walker A motif; other site
485915001813	ATP binding site [chemical binding]; other site
485915001814	Walker B motif; other site
485915001815	arginine finger; other site
485915001816	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
485915001817	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
485915001818	Ferritin-like domain; Region: Ferritin; pfam00210
485915001819	ferroxidase diiron center [ion binding]; other site
485915001820	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
485915001821	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
485915001822	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
485915001823	dimer interface [polypeptide binding]; other site
485915001824	PYR/PP interface [polypeptide binding]; other site
485915001825	TPP binding site [chemical binding]; other site
485915001826	substrate binding site [chemical binding]; other site
485915001827	2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family; Region: PorB_KorB; TIGR02177
485915001828	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
485915001829	TPP-binding site [chemical binding]; other site
485915001830	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
485915001831	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
485915001832	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
485915001833	catalytic residues [active]
485915001834	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
485915001835	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
485915001836	dimer interface [polypeptide binding]; other site
485915001837	catalytic triad [active]
485915001838	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
485915001839	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
485915001840	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
485915001841	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
485915001842	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
485915001843	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
485915001844	putative active site [active]
485915001845	putative substrate binding site [chemical binding]; other site
485915001846	putative cosubstrate binding site; other site
485915001847	catalytic site [active]
485915001848	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
485915001849	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915001850	Walker A/P-loop; other site
485915001851	ATP binding site [chemical binding]; other site
485915001852	Q-loop/lid; other site
485915001853	ABC transporter signature motif; other site
485915001854	Walker B; other site
485915001855	D-loop; other site
485915001856	molybdate ABC transporter periplasmic substrate-binding protein; Provisional; Region: PRK04168
485915001857	tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730
485915001858	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
485915001859	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
485915001860	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915001861	dimer interface [polypeptide binding]; other site
485915001862	conserved gate region; other site
485915001863	putative PBP binding loops; other site
485915001864	ABC-ATPase subunit interface; other site
485915001865	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
485915001866	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915001867	Walker A/P-loop; other site
485915001868	ATP binding site [chemical binding]; other site
485915001869	Q-loop/lid; other site
485915001870	ABC transporter signature motif; other site
485915001871	Walker B; other site
485915001872	D-loop; other site
485915001873	H-loop/switch region; other site
485915001874	TOBE domain; Region: TOBE_2; pfam08402
485915001875	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
485915001876	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915001877	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
485915001878	FMN-binding domain; Region: FMN_bind; cl01081
485915001879	electron transport complex RsxE subunit; Provisional; Region: PRK12405
485915001880	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
485915001881	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915001882	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
485915001883	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915001884	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
485915001885	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
485915001886	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
485915001887	Ligand Binding Site [chemical binding]; other site
485915001888	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
485915001889	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
485915001890	ApbE family; Region: ApbE; pfam02424
485915001891	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
485915001892	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
485915001893	active site
485915001894	HIGH motif; other site
485915001895	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
485915001896	KMSKS motif; other site
485915001897	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
485915001898	tRNA binding surface [nucleotide binding]; other site
485915001899	anticodon binding site; other site
485915001900	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
485915001901	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
485915001902	substrate binding site; other site
485915001903	dimer interface; other site
485915001904	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
485915001905	homotrimer interaction site [polypeptide binding]; other site
485915001906	zinc binding site [ion binding]; other site
485915001907	CDP-binding sites; other site
485915001908	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
485915001909	Putative zinc ribbon domain; Region: DUF164; pfam02591
485915001910	Uncharacterized conserved protein [Function unknown]; Region: COG0327
485915001911	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
485915001912	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
485915001913	conserved hypothetical integral membrane protein; Region: TIGR00697
485915001914	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
485915001915	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
485915001916	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
485915001917	CoA-ligase; Region: Ligase_CoA; pfam00549
485915001918	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
485915001919	CoA binding domain; Region: CoA_binding; smart00881
485915001920	CoA-ligase; Region: Ligase_CoA; pfam00549
485915001921	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
485915001922	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
485915001923	dimerization interface [polypeptide binding]; other site
485915001924	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
485915001925	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915001926	putative active site [active]
485915001927	heme pocket [chemical binding]; other site
485915001928	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915001929	dimer interface [polypeptide binding]; other site
485915001930	phosphorylation site [posttranslational modification]
485915001931	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915001932	ATP binding site [chemical binding]; other site
485915001933	Mg2+ binding site [ion binding]; other site
485915001934	G-X-G motif; other site
485915001935	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
485915001936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915001937	active site
485915001938	phosphorylation site [posttranslational modification]
485915001939	intermolecular recognition site; other site
485915001940	dimerization interface [polypeptide binding]; other site
485915001941	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915001942	Walker A motif; other site
485915001943	ATP binding site [chemical binding]; other site
485915001944	Walker B motif; other site
485915001945	arginine finger; other site
485915001946	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915001947	intracellular protease, PfpI family; Region: PfpI; TIGR01382
485915001948	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
485915001949	conserved cys residue [active]
485915001950	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
485915001951	feedback inhibition sensing region; other site
485915001952	homohexameric interface [polypeptide binding]; other site
485915001953	nucleotide binding site [chemical binding]; other site
485915001954	N-acetyl-L-glutamate binding site [chemical binding]; other site
485915001955	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
485915001956	Transposase; Region: DDE_Tnp_ISL3; pfam01610
485915001957	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
485915001958	CoenzymeA binding site [chemical binding]; other site
485915001959	subunit interaction site [polypeptide binding]; other site
485915001960	PHB binding site; other site
485915001961	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
485915001962	ADP-ribose binding site [chemical binding]; other site
485915001963	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
485915001964	active site
485915001965	HslU subunit interaction site [polypeptide binding]; other site
485915001966	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
485915001967	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915001968	Walker A motif; other site
485915001969	ATP binding site [chemical binding]; other site
485915001970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915001971	Walker B motif; other site
485915001972	arginine finger; other site
485915001973	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
485915001974	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
485915001975	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
485915001976	DctM-like transporters; Region: DctM; pfam06808
485915001977	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
485915001978	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
485915001979	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
485915001980	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
485915001981	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
485915001982	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
485915001983	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
485915001984	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
485915001985	VCBS repeat; Region: VCBS_repeat; TIGR01965
485915001986	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
485915001987	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
485915001988	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
485915001989	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
485915001990	Walker A/P-loop; other site
485915001991	ATP binding site [chemical binding]; other site
485915001992	Q-loop/lid; other site
485915001993	ABC transporter signature motif; other site
485915001994	Walker B; other site
485915001995	D-loop; other site
485915001996	H-loop/switch region; other site
485915001997	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
485915001998	HlyD family secretion protein; Region: HlyD_3; pfam13437
485915001999	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
485915002000	PAS fold; Region: PAS_4; pfam08448
485915002001	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
485915002002	Zn2+ binding site [ion binding]; other site
485915002003	Mg2+ binding site [ion binding]; other site
485915002004	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
485915002005	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915002006	Walker A motif; other site
485915002007	ATP binding site [chemical binding]; other site
485915002008	Walker B motif; other site
485915002009	arginine finger; other site
485915002010	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915002011	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
485915002012	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
485915002013	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
485915002014	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
485915002015	FliG C-terminal domain; Region: FliG_C; pfam01706
485915002016	flagellar assembly protein H; Validated; Region: fliH; PRK06669
485915002017	Flagellar assembly protein FliH; Region: FliH; pfam02108
485915002018	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
485915002019	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
485915002020	Walker A motif/ATP binding site; other site
485915002021	Walker B motif; other site
485915002022	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
485915002023	Uncharacterized conserved protein [Function unknown]; Region: COG3334
485915002024	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
485915002025	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
485915002026	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
485915002027	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
485915002028	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
485915002029	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
485915002030	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
485915002031	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
485915002032	flagellar motor protein MotP; Reviewed; Region: PRK06926
485915002033	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
485915002034	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
485915002035	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
485915002036	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
485915002037	ligand binding site [chemical binding]; other site
485915002038	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
485915002039	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
485915002040	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
485915002041	flagellar motor switch protein FliN; Region: fliN; TIGR02480
485915002042	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
485915002043	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
485915002044	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
485915002045	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
485915002046	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
485915002047	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
485915002048	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
485915002049	FHIPEP family; Region: FHIPEP; pfam00771
485915002050	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
485915002051	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
485915002052	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
485915002053	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
485915002054	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
485915002055	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
485915002056	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
485915002057	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
485915002058	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
485915002059	DNA binding residues [nucleotide binding]
485915002060	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
485915002061	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
485915002062	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
485915002063	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
485915002064	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
485915002065	SAF-like; Region: SAF_2; pfam13144
485915002066	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
485915002067	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
485915002068	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
485915002069	Flagellar L-ring protein; Region: FlgH; pfam02107
485915002070	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
485915002071	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
485915002072	Rod binding protein; Region: Rod-binding; cl01626
485915002073	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
485915002074	Transposase; Region: DDE_Tnp_ISL3; pfam01610
485915002075	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
485915002076	FlgN protein; Region: FlgN; cl09176
485915002077	Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256
485915002078	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
485915002079	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
485915002080	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
485915002081	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
485915002082	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
485915002083	Global regulator protein family; Region: CsrA; pfam02599
485915002084	flagellar assembly protein FliW; Provisional; Region: PRK13285
485915002085	SprA-related family; Region: SprA-related; pfam12118
485915002086	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
485915002087	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
485915002088	NAD(P) binding site [chemical binding]; other site
485915002089	homodimer interface [polypeptide binding]; other site
485915002090	substrate binding site [chemical binding]; other site
485915002091	active site
485915002092	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
485915002093	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
485915002094	inhibitor-cofactor binding pocket; inhibition site
485915002095	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915002096	catalytic residue [active]
485915002097	Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980
485915002098	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
485915002099	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
485915002100	metal binding site [ion binding]; metal-binding site
485915002101	Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546
485915002102	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
485915002103	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
485915002104	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
485915002105	NeuB family; Region: NeuB; pfam03102
485915002106	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
485915002107	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
485915002108	active site
485915002109	substrate binding site [chemical binding]; other site
485915002110	cosubstrate binding site; other site
485915002111	catalytic site [active]
485915002112	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
485915002113	active site
485915002114	hexamer interface [polypeptide binding]; other site
485915002115	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
485915002116	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
485915002117	ligand binding site; other site
485915002118	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
485915002119	Methyltransferase domain; Region: Methyltransf_23; pfam13489
485915002120	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915002121	S-adenosylmethionine binding site [chemical binding]; other site
485915002122	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
485915002123	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
485915002124	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
485915002125	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
485915002126	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
485915002127	ligand binding site; other site
485915002128	tetramer interface; other site
485915002129	Transposase [DNA replication, recombination, and repair]; Region: COG5421
485915002130	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
485915002131	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
485915002132	putative active site [active]
485915002133	putative NTP binding site [chemical binding]; other site
485915002134	putative nucleic acid binding site [nucleotide binding]; other site
485915002135	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
485915002136	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
485915002137	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
485915002138	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
485915002139	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
485915002140	putative active site [active]
485915002141	putative NTP binding site [chemical binding]; other site
485915002142	putative nucleic acid binding site [nucleotide binding]; other site
485915002143	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
485915002144	TPR repeat; Region: TPR_11; pfam13414
485915002145	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915002146	TPR motif; other site
485915002147	binding surface
485915002148	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
485915002149	flagellin; Provisional; Region: PRK12802
485915002150	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
485915002151	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
485915002152	flagellin; Provisional; Region: PRK12802
485915002153	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
485915002154	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
485915002155	FlaG protein; Region: FlaG; pfam03646
485915002156	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
485915002157	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
485915002158	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
485915002159	Flagellar protein FliS; Region: FliS; cl00654
485915002160	PilZ domain; Region: PilZ; pfam07238
485915002161	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
485915002162	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915002163	Walker A motif; other site
485915002164	ATP binding site [chemical binding]; other site
485915002165	Walker B motif; other site
485915002166	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
485915002167	Integrase core domain; Region: rve; pfam00665
485915002168	Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777
485915002169	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
485915002170	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
485915002171	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
485915002172	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
485915002173	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
485915002174	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
485915002175	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
485915002176	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
485915002177	Transposase; Region: DDE_Tnp_ISL3; pfam01610
485915002178	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
485915002179	response regulator PleD; Reviewed; Region: pleD; PRK09581
485915002180	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
485915002181	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
485915002182	Response regulator receiver domain; Region: Response_reg; pfam00072
485915002183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915002184	active site
485915002185	phosphorylation site [posttranslational modification]
485915002186	intermolecular recognition site; other site
485915002187	dimerization interface [polypeptide binding]; other site
485915002188	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
485915002189	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
485915002190	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
485915002191	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
485915002192	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
485915002193	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
485915002194	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
485915002195	putative binding surface; other site
485915002196	active site
485915002197	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
485915002198	putative binding surface; other site
485915002199	active site
485915002200	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
485915002201	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
485915002202	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915002203	ATP binding site [chemical binding]; other site
485915002204	Mg2+ binding site [ion binding]; other site
485915002205	G-X-G motif; other site
485915002206	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
485915002207	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
485915002208	dimer interface [polypeptide binding]; other site
485915002209	putative CheW interface [polypeptide binding]; other site
485915002210	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
485915002211	putative CheA interaction surface; other site
485915002212	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
485915002213	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
485915002214	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
485915002215	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
485915002216	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
485915002217	dimer interface [polypeptide binding]; other site
485915002218	putative CheW interface [polypeptide binding]; other site
485915002219	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
485915002220	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
485915002221	dimer interface [polypeptide binding]; other site
485915002222	putative CheW interface [polypeptide binding]; other site
485915002223	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
485915002224	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
485915002225	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915002226	S-adenosylmethionine binding site [chemical binding]; other site
485915002227	CheD chemotactic sensory transduction; Region: CheD; cl00810
485915002228	Response regulator receiver domain; Region: Response_reg; pfam00072
485915002229	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915002230	active site
485915002231	phosphorylation site [posttranslational modification]
485915002232	intermolecular recognition site; other site
485915002233	dimerization interface [polypeptide binding]; other site
485915002234	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
485915002235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915002236	active site
485915002237	phosphorylation site [posttranslational modification]
485915002238	intermolecular recognition site; other site
485915002239	dimerization interface [polypeptide binding]; other site
485915002240	CheB methylesterase; Region: CheB_methylest; pfam01339
485915002241	Late competence development protein ComFB; Region: ComFB; pfam10719
485915002242	HDOD domain; Region: HDOD; pfam08668
485915002243	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503
485915002244	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
485915002245	CheD chemotactic sensory transduction; Region: CheD; cl00810
485915002246	HDOD domain; Region: HDOD; pfam08668
485915002247	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
485915002248	Zn2+ binding site [ion binding]; other site
485915002249	Mg2+ binding site [ion binding]; other site
485915002250	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
485915002251	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
485915002252	dimerization interface [polypeptide binding]; other site
485915002253	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
485915002254	cyclase homology domain; Region: CHD; cd07302
485915002255	nucleotidyl binding site; other site
485915002256	metal binding site [ion binding]; metal-binding site
485915002257	dimer interface [polypeptide binding]; other site
485915002258	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
485915002259	B12 binding domain; Region: B12-binding_2; pfam02607
485915002260	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
485915002261	B12 binding domain; Region: B12-binding; pfam02310
485915002262	B12 binding site [chemical binding]; other site
485915002263	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915002264	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915002265	metal binding site [ion binding]; metal-binding site
485915002266	active site
485915002267	I-site; other site
485915002268	Uncharacterized conserved protein [Function unknown]; Region: COG3379
485915002269	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
485915002270	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
485915002271	Permease; Region: Permease; pfam02405
485915002272	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
485915002273	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
485915002274	Walker A/P-loop; other site
485915002275	ATP binding site [chemical binding]; other site
485915002276	Q-loop/lid; other site
485915002277	ABC transporter signature motif; other site
485915002278	Walker B; other site
485915002279	D-loop; other site
485915002280	H-loop/switch region; other site
485915002281	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
485915002282	mce related protein; Region: MCE; pfam02470
485915002283	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
485915002284	active site
485915002285	metal binding site [ion binding]; metal-binding site
485915002286	homotetramer interface [polypeptide binding]; other site
485915002287	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
485915002288	rRNA binding site [nucleotide binding]; other site
485915002289	predicted 30S ribosome binding site; other site
485915002290	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
485915002291	shikimate kinase; Reviewed; Region: aroK; PRK00131
485915002292	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
485915002293	ADP binding site [chemical binding]; other site
485915002294	magnesium binding site [ion binding]; other site
485915002295	putative shikimate binding site; other site
485915002296	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
485915002297	amino acid carrier protein; Region: agcS; TIGR00835
485915002298	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
485915002299	dimer interface [polypeptide binding]; other site
485915002300	active site
485915002301	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
485915002302	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
485915002303	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
485915002304	domain interfaces; other site
485915002305	active site
485915002306	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
485915002307	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
485915002308	pyruvate carboxylase; Reviewed; Region: PRK12999
485915002309	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
485915002310	ATP-grasp domain; Region: ATP-grasp_4; cl17255
485915002311	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
485915002312	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
485915002313	active site
485915002314	catalytic residues [active]
485915002315	metal binding site [ion binding]; metal-binding site
485915002316	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
485915002317	carboxyltransferase (CT) interaction site; other site
485915002318	biotinylation site [posttranslational modification]; other site
485915002319	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
485915002320	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
485915002321	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
485915002322	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
485915002323	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
485915002324	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
485915002325	Coenzyme A binding pocket [chemical binding]; other site
485915002326	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
485915002327	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915002328	FeS/SAM binding site; other site
485915002329	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
485915002330	Lipase (class 2); Region: Lipase_2; pfam01674
485915002331	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
485915002332	PGAP1-like protein; Region: PGAP1; pfam07819
485915002333	CoA binding domain; Region: CoA_binding_2; pfam13380
485915002334	Ion channel; Region: Ion_trans_2; pfam07885
485915002335	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
485915002336	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915002337	active site
485915002338	phosphorylation site [posttranslational modification]
485915002339	intermolecular recognition site; other site
485915002340	dimerization interface [polypeptide binding]; other site
485915002341	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915002342	Walker A motif; other site
485915002343	ATP binding site [chemical binding]; other site
485915002344	Walker B motif; other site
485915002345	arginine finger; other site
485915002346	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915002347	Predicted transcriptional regulators [Transcription]; Region: COG1733
485915002348	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
485915002349	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
485915002350	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
485915002351	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
485915002352	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
485915002353	FtsH Extracellular; Region: FtsH_ext; pfam06480
485915002354	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
485915002355	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915002356	Walker A motif; other site
485915002357	ATP binding site [chemical binding]; other site
485915002358	Walker B motif; other site
485915002359	arginine finger; other site
485915002360	Peptidase family M41; Region: Peptidase_M41; pfam01434
485915002361	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
485915002362	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
485915002363	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
485915002364	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
485915002365	Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656
485915002366	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
485915002367	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
485915002368	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
485915002369	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915002370	S-adenosylmethionine binding site [chemical binding]; other site
485915002371	FOG: CBS domain [General function prediction only]; Region: COG0517
485915002372	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
485915002373	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
485915002374	hypothetical protein; Provisional; Region: PRK04194
485915002375	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
485915002376	Peptidase family U32; Region: Peptidase_U32; pfam01136
485915002377	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
485915002378	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
485915002379	active site
485915002380	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
485915002381	Uncharacterized conserved protein [Function unknown]; Region: COG2835
485915002382	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
485915002383	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
485915002384	putative dimer interface [polypeptide binding]; other site
485915002385	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
485915002386	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
485915002387	putative dimer interface [polypeptide binding]; other site
485915002388	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
485915002389	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
485915002390	active site
485915002391	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
485915002392	ligand binding site [chemical binding]; other site
485915002393	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
485915002394	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
485915002395	ligand binding site [chemical binding]; other site
485915002396	flexible hinge region; other site
485915002397	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
485915002398	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
485915002399	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
485915002400	active site
485915002401	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
485915002402	thiS-thiF/thiG interaction site; other site
485915002403	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
485915002404	ThiS interaction site; other site
485915002405	putative active site [active]
485915002406	tetramer interface [polypeptide binding]; other site
485915002407	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
485915002408	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
485915002409	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
485915002410	ATP binding site [chemical binding]; other site
485915002411	substrate interface [chemical binding]; other site
485915002412	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
485915002413	thiamine phosphate binding site [chemical binding]; other site
485915002414	active site
485915002415	pyrophosphate binding site [ion binding]; other site
485915002416	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
485915002417	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915002418	FeS/SAM binding site; other site
485915002419	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
485915002420	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
485915002421	dimerization interface [polypeptide binding]; other site
485915002422	putative ATP binding site [chemical binding]; other site
485915002423	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915002424	Radical SAM superfamily; Region: Radical_SAM; pfam04055
485915002425	FeS/SAM binding site; other site
485915002426	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
485915002427	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
485915002428	23S rRNA interface [nucleotide binding]; other site
485915002429	L3 interface [polypeptide binding]; other site
485915002430	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
485915002431	HD domain; Region: HD_3; pfam13023
485915002432	cell division protein MraZ; Reviewed; Region: PRK00326
485915002433	MraZ protein; Region: MraZ; pfam02381
485915002434	MraZ protein; Region: MraZ; pfam02381
485915002435	MraW methylase family; Region: Methyltransf_5; cl17771
485915002436	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
485915002437	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
485915002438	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
485915002439	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
485915002440	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
485915002441	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
485915002442	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
485915002443	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
485915002444	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
485915002445	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
485915002446	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
485915002447	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
485915002448	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
485915002449	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
485915002450	Mg++ binding site [ion binding]; other site
485915002451	putative catalytic motif [active]
485915002452	putative substrate binding site [chemical binding]; other site
485915002453	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
485915002454	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
485915002455	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
485915002456	cell division protein FtsW; Region: ftsW; TIGR02614
485915002457	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
485915002458	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
485915002459	active site
485915002460	homodimer interface [polypeptide binding]; other site
485915002461	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
485915002462	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
485915002463	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
485915002464	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
485915002465	UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812
485915002466	FAD binding domain; Region: FAD_binding_4; pfam01565
485915002467	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
485915002468	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
485915002469	cell division protein FtsA; Region: ftsA; TIGR01174
485915002470	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
485915002471	nucleotide binding site [chemical binding]; other site
485915002472	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
485915002473	Cell division protein FtsA; Region: FtsA; pfam14450
485915002474	cell division protein FtsZ; Validated; Region: PRK09330
485915002475	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
485915002476	nucleotide binding site [chemical binding]; other site
485915002477	SulA interaction site; other site
485915002478	heat shock protein 90; Provisional; Region: PRK05218
485915002479	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915002480	ATP binding site [chemical binding]; other site
485915002481	Mg2+ binding site [ion binding]; other site
485915002482	G-X-G motif; other site
485915002483	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
485915002484	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
485915002485	molybdopterin cofactor binding site; other site
485915002486	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
485915002487	molybdopterin cofactor binding site; other site
485915002488	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
485915002489	cobalt transport protein CbiM; Validated; Region: PRK06265
485915002490	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
485915002491	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
485915002492	Ligand Binding Site [chemical binding]; other site
485915002493	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
485915002494	selenocysteine synthase; Provisional; Region: PRK04311
485915002495	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
485915002496	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
485915002497	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
485915002498	catalytic residue [active]
485915002499	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
485915002500	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
485915002501	oligomer interface [polypeptide binding]; other site
485915002502	putative active site [active]
485915002503	metal binding site [ion binding]; metal-binding site
485915002504	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
485915002505	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
485915002506	G1 box; other site
485915002507	putative GEF interaction site [polypeptide binding]; other site
485915002508	GTP/Mg2+ binding site [chemical binding]; other site
485915002509	Switch I region; other site
485915002510	G2 box; other site
485915002511	G3 box; other site
485915002512	Switch II region; other site
485915002513	G4 box; other site
485915002514	G5 box; other site
485915002515	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
485915002516	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
485915002517	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
485915002518	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
485915002519	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
485915002520	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
485915002521	hinge; other site
485915002522	active site
485915002523	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
485915002524	Competence protein; Region: Competence; pfam03772
485915002525	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
485915002526	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
485915002527	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
485915002528	active site
485915002529	HIGH motif; other site
485915002530	dimer interface [polypeptide binding]; other site
485915002531	KMSKS motif; other site
485915002532	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
485915002533	Peptidase family M50; Region: Peptidase_M50; pfam02163
485915002534	active site
485915002535	putative substrate binding region [chemical binding]; other site
485915002536	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
485915002537	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
485915002538	active site
485915002539	CoA binding domain; Region: CoA_binding; cl17356
485915002540	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
485915002541	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
485915002542	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915002543	dimer interface [polypeptide binding]; other site
485915002544	conserved gate region; other site
485915002545	ABC-ATPase subunit interface; other site
485915002546	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915002547	dimer interface [polypeptide binding]; other site
485915002548	conserved gate region; other site
485915002549	putative PBP binding loops; other site
485915002550	ABC-ATPase subunit interface; other site
485915002551	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
485915002552	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
485915002553	Walker A/P-loop; other site
485915002554	ATP binding site [chemical binding]; other site
485915002555	Q-loop/lid; other site
485915002556	ABC transporter signature motif; other site
485915002557	Walker B; other site
485915002558	D-loop; other site
485915002559	H-loop/switch region; other site
485915002560	FOG: CBS domain [General function prediction only]; Region: COG0517
485915002561	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
485915002562	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
485915002563	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
485915002564	Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973
485915002565	catalytic residues [active]
485915002566	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
485915002567	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
485915002568	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
485915002569	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
485915002570	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
485915002571	catalytic core [active]
485915002572	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
485915002573	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
485915002574	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
485915002575	substrate binding pocket [chemical binding]; other site
485915002576	membrane-bound complex binding site; other site
485915002577	hinge residues; other site
485915002578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
485915002579	Major Facilitator Superfamily; Region: MFS_1; pfam07690
485915002580	putative substrate translocation pore; other site
485915002581	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
485915002582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915002583	active site
485915002584	phosphorylation site [posttranslational modification]
485915002585	intermolecular recognition site; other site
485915002586	dimerization interface [polypeptide binding]; other site
485915002587	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915002588	Walker A motif; other site
485915002589	ATP binding site [chemical binding]; other site
485915002590	Walker B motif; other site
485915002591	arginine finger; other site
485915002592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
485915002593	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
485915002594	putative active site [active]
485915002595	heme pocket [chemical binding]; other site
485915002596	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915002597	putative active site [active]
485915002598	heme pocket [chemical binding]; other site
485915002599	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915002600	dimer interface [polypeptide binding]; other site
485915002601	phosphorylation site [posttranslational modification]
485915002602	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915002603	ATP binding site [chemical binding]; other site
485915002604	Mg2+ binding site [ion binding]; other site
485915002605	G-X-G motif; other site
485915002606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915002607	active site
485915002608	phosphorylation site [posttranslational modification]
485915002609	intermolecular recognition site; other site
485915002610	dimerization interface [polypeptide binding]; other site
485915002611	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
485915002612	Malic enzyme, N-terminal domain; Region: malic; pfam00390
485915002613	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
485915002614	putative NAD(P) binding site [chemical binding]; other site
485915002615	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
485915002616	Flavoprotein; Region: Flavoprotein; pfam02441
485915002617	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
485915002618	NADPH bind site [chemical binding]; other site
485915002619	putative FMN binding site [chemical binding]; other site
485915002620	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
485915002621	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
485915002622	putative catalytic cysteine [active]
485915002623	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
485915002624	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
485915002625	active site
485915002626	(T/H)XGH motif; other site
485915002627	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
485915002628	DnaA N-terminal domain; Region: DnaA_N; pfam11638
485915002629	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
485915002630	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
485915002631	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915002632	Walker A motif; other site
485915002633	ATP binding site [chemical binding]; other site
485915002634	Walker B motif; other site
485915002635	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
485915002636	DnaA box-binding interface [nucleotide binding]; other site
485915002637	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
485915002638	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
485915002639	ligand binding site [chemical binding]; other site
485915002640	flexible hinge region; other site
485915002641	hydrogenase membrane subunit; Validated; Region: PRK08676
485915002642	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
485915002643	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
485915002644	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
485915002645	E3 interaction surface; other site
485915002646	lipoyl attachment site [posttranslational modification]; other site
485915002647	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
485915002648	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
485915002649	hydrogenase 4 subunit F; Validated; Region: PRK06458
485915002650	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
485915002651	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
485915002652	Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320
485915002653	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
485915002654	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
485915002655	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
485915002656	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
485915002657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915002658	catalytic residue [active]
485915002659	excinuclease ABC subunit B; Provisional; Region: PRK05298
485915002660	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
485915002661	ATP binding site [chemical binding]; other site
485915002662	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
485915002663	nucleotide binding region [chemical binding]; other site
485915002664	ATP-binding site [chemical binding]; other site
485915002665	Ultra-violet resistance protein B; Region: UvrB; pfam12344
485915002666	UvrB/uvrC motif; Region: UVR; pfam02151
485915002667	Ion channel; Region: Ion_trans_2; pfam07885
485915002668	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
485915002669	TrkA-N domain; Region: TrkA_N; pfam02254
485915002670	TrkA-C domain; Region: TrkA_C; pfam02080
485915002671	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
485915002672	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
485915002673	nucleotide binding pocket [chemical binding]; other site
485915002674	K-X-D-G motif; other site
485915002675	catalytic site [active]
485915002676	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
485915002677	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
485915002678	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
485915002679	Dimer interface [polypeptide binding]; other site
485915002680	BRCT sequence motif; other site
485915002681	Uncharacterized conserved protein [Function unknown]; Region: COG2006
485915002682	Domain of unknown function (DUF362); Region: DUF362; pfam04015
485915002683	dihydrodipicolinate reductase; Provisional; Region: PRK00048
485915002684	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
485915002685	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
485915002686	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
485915002687	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
485915002688	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
485915002689	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
485915002690	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
485915002691	RNA binding surface [nucleotide binding]; other site
485915002692	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
485915002693	active site
485915002694	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
485915002695	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
485915002696	CPxP  motif; other site
485915002697	DsrE/DsrF-like family; Region: DrsE; pfam02635
485915002698	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
485915002699	putative acyl-acceptor binding pocket; other site
485915002700	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
485915002701	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
485915002702	putative acyl-acceptor binding pocket; other site
485915002703	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
485915002704	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
485915002705	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
485915002706	putative active site [active]
485915002707	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
485915002708	nudix motif; other site
485915002709	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
485915002710	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
485915002711	nucleotide binding site [chemical binding]; other site
485915002712	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
485915002713	glycogen synthase; Provisional; Region: glgA; PRK00654
485915002714	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
485915002715	ADP-binding pocket [chemical binding]; other site
485915002716	homodimer interface [polypeptide binding]; other site
485915002717	N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184
485915002718	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
485915002719	Cupin domain; Region: Cupin_2; pfam07883
485915002720	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
485915002721	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
485915002722	acyl-activating enzyme (AAE) consensus motif; other site
485915002723	AMP binding site [chemical binding]; other site
485915002724	active site
485915002725	CoA binding site [chemical binding]; other site
485915002726	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
485915002727	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
485915002728	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
485915002729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915002730	active site
485915002731	phosphorylation site [posttranslational modification]
485915002732	intermolecular recognition site; other site
485915002733	dimerization interface [polypeptide binding]; other site
485915002734	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
485915002735	DNA binding residues [nucleotide binding]
485915002736	dimerization interface [polypeptide binding]; other site
485915002737	AAA domain; Region: AAA_32; pfam13654
485915002738	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
485915002739	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
485915002740	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
485915002741	Ligand Binding Site [chemical binding]; other site
485915002742	Response regulator receiver domain; Region: Response_reg; pfam00072
485915002743	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915002744	active site
485915002745	phosphorylation site [posttranslational modification]
485915002746	intermolecular recognition site; other site
485915002747	dimerization interface [polypeptide binding]; other site
485915002748	Response regulator receiver domain; Region: Response_reg; pfam00072
485915002749	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915002750	active site
485915002751	phosphorylation site [posttranslational modification]
485915002752	intermolecular recognition site; other site
485915002753	dimerization interface [polypeptide binding]; other site
485915002754	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
485915002755	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
485915002756	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
485915002757	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
485915002758	minor groove reading motif; other site
485915002759	helix-hairpin-helix signature motif; other site
485915002760	substrate binding pocket [chemical binding]; other site
485915002761	active site
485915002762	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
485915002763	Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding; Region: Dehyd-heme_bind; pfam09098
485915002764	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
485915002765	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
485915002766	active site
485915002767	ATP binding site [chemical binding]; other site
485915002768	substrate binding site [chemical binding]; other site
485915002769	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
485915002770	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
485915002771	dimer interface [polypeptide binding]; other site
485915002772	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915002773	catalytic residue [active]
485915002774	cysteinyl-tRNA synthetase; Region: cysS; TIGR00435
485915002775	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
485915002776	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
485915002777	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915002778	Walker A motif; other site
485915002779	ATP binding site [chemical binding]; other site
485915002780	Walker B motif; other site
485915002781	arginine finger; other site
485915002782	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915002783	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
485915002784	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
485915002785	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
485915002786	dimer interface [polypeptide binding]; other site
485915002787	PYR/PP interface [polypeptide binding]; other site
485915002788	TPP binding site [chemical binding]; other site
485915002789	substrate binding site [chemical binding]; other site
485915002790	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
485915002791	TPP-binding site; other site
485915002792	4Fe-4S binding domain; Region: Fer4; pfam00037
485915002793	Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700
485915002794	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
485915002795	Protein export membrane protein; Region: SecD_SecF; cl14618
485915002796	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
485915002797	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
485915002798	HlyD family secretion protein; Region: HlyD_3; pfam13437
485915002799	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
485915002800	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
485915002801	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
485915002802	protein binding site [polypeptide binding]; other site
485915002803	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
485915002804	protein binding site [polypeptide binding]; other site
485915002805	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14615
485915002806	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
485915002807	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
485915002808	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
485915002809	active site
485915002810	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
485915002811	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
485915002812	5S rRNA interface [nucleotide binding]; other site
485915002813	CTC domain interface [polypeptide binding]; other site
485915002814	L16 interface [polypeptide binding]; other site
485915002815	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
485915002816	putative active site [active]
485915002817	catalytic residue [active]
485915002818	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
485915002819	transcription termination factor Rho; Provisional; Region: rho; PRK09376
485915002820	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
485915002821	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
485915002822	RNA binding site [nucleotide binding]; other site
485915002823	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
485915002824	multimer interface [polypeptide binding]; other site
485915002825	Walker A motif; other site
485915002826	ATP binding site [chemical binding]; other site
485915002827	Walker B motif; other site
485915002828	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
485915002829	Peptidase family M48; Region: Peptidase_M48; pfam01435
485915002830	Preprotein translocase subunit; Region: YajC; pfam02699
485915002831	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
485915002832	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
485915002833	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
485915002834	Protein export membrane protein; Region: SecD_SecF; pfam02355
485915002835	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
485915002836	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
485915002837	putative active site [active]
485915002838	putative NTP binding site [chemical binding]; other site
485915002839	putative nucleic acid binding site [nucleotide binding]; other site
485915002840	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
485915002841	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
485915002842	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
485915002843	putative active site [active]
485915002844	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
485915002845	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
485915002846	TPP-binding site [chemical binding]; other site
485915002847	dimer interface [polypeptide binding]; other site
485915002848	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
485915002849	PYR/PP interface [polypeptide binding]; other site
485915002850	dimer interface [polypeptide binding]; other site
485915002851	TPP binding site [chemical binding]; other site
485915002852	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
485915002853	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
485915002854	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915002855	binding surface
485915002856	Tetratricopeptide repeat; Region: TPR_16; pfam13432
485915002857	TPR motif; other site
485915002858	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915002859	TPR motif; other site
485915002860	TPR repeat; Region: TPR_11; pfam13414
485915002861	binding surface
485915002862	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915002863	binding surface
485915002864	TPR motif; other site
485915002865	TPR repeat; Region: TPR_11; pfam13414
485915002866	TPR repeat; Region: TPR_11; pfam13414
485915002867	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915002868	binding surface
485915002869	TPR motif; other site
485915002870	TPR repeat; Region: TPR_11; pfam13414
485915002871	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
485915002872	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
485915002873	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
485915002874	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
485915002875	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
485915002876	DNA binding residues [nucleotide binding]
485915002877	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
485915002878	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
485915002879	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
485915002880	substrate binding pocket [chemical binding]; other site
485915002881	dimer interface [polypeptide binding]; other site
485915002882	inhibitor binding site; inhibition site
485915002883	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
485915002884	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
485915002885	B12 binding site [chemical binding]; other site
485915002886	cobalt ligand [ion binding]; other site
485915002887	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
485915002888	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
485915002889	catalytic residues [active]
485915002890	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
485915002891	Coenzyme A binding pocket [chemical binding]; other site
485915002892	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
485915002893	active site
485915002894	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
485915002895	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
485915002896	DNA repair protein RadA; Provisional; Region: PRK11823
485915002897	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
485915002898	Walker A motif; other site
485915002899	ATP binding site [chemical binding]; other site
485915002900	Walker B motif; other site
485915002901	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
485915002902	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
485915002903	Transcriptional regulator; Region: Rrf2; cl17282
485915002904	Rrf2 family protein; Region: rrf2_super; TIGR00738
485915002905	Response regulator receiver domain; Region: Response_reg; pfam00072
485915002906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915002907	active site
485915002908	phosphorylation site [posttranslational modification]
485915002909	intermolecular recognition site; other site
485915002910	dimerization interface [polypeptide binding]; other site
485915002911	PAS fold; Region: PAS_4; pfam08448
485915002912	PAS domain; Region: PAS_9; pfam13426
485915002913	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915002914	ATP binding site [chemical binding]; other site
485915002915	Mg2+ binding site [ion binding]; other site
485915002916	G-X-G motif; other site
485915002917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915002918	Response regulator receiver domain; Region: Response_reg; pfam00072
485915002919	active site
485915002920	phosphorylation site [posttranslational modification]
485915002921	intermolecular recognition site; other site
485915002922	dimerization interface [polypeptide binding]; other site
485915002923	Response regulator receiver domain; Region: Response_reg; pfam00072
485915002924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915002925	active site
485915002926	phosphorylation site [posttranslational modification]
485915002927	intermolecular recognition site; other site
485915002928	dimerization interface [polypeptide binding]; other site
485915002929	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
485915002930	Ligand Binding Site [chemical binding]; other site
485915002931	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
485915002932	Ligand Binding Site [chemical binding]; other site
485915002933	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
485915002934	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
485915002935	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
485915002936	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
485915002937	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
485915002938	4Fe-4S binding domain; Region: Fer4; pfam00037
485915002939	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
485915002940	heme-binding residues [chemical binding]; other site
485915002941	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
485915002942	heme-binding residues [chemical binding]; other site
485915002943	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
485915002944	heme-binding residues [chemical binding]; other site
485915002945	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
485915002946	heme-binding residues [chemical binding]; other site
485915002947	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
485915002948	dimerization interface [polypeptide binding]; other site
485915002949	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
485915002950	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
485915002951	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915002952	putative active site [active]
485915002953	heme pocket [chemical binding]; other site
485915002954	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915002955	dimer interface [polypeptide binding]; other site
485915002956	phosphorylation site [posttranslational modification]
485915002957	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915002958	ATP binding site [chemical binding]; other site
485915002959	Mg2+ binding site [ion binding]; other site
485915002960	G-X-G motif; other site
485915002961	Transcriptional regulator; Region: Rrf2; cl17282
485915002962	Rrf2 family protein; Region: rrf2_super; TIGR00738
485915002963	Rice tungro bacilliform virus P46 protein; Region: RTBV_P46; pfam06216
485915002964	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
485915002965	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
485915002966	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
485915002967	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
485915002968	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
485915002969	putative active site [active]
485915002970	putative NTP binding site [chemical binding]; other site
485915002971	putative nucleic acid binding site [nucleotide binding]; other site
485915002972	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
485915002973	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
485915002974	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
485915002975	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
485915002976	ATP binding site [chemical binding]; other site
485915002977	putative Mg++ binding site [ion binding]; other site
485915002978	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
485915002979	nucleotide binding region [chemical binding]; other site
485915002980	ATP-binding site [chemical binding]; other site
485915002981	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
485915002982	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
485915002983	Zn2+ binding site [ion binding]; other site
485915002984	Mg2+ binding site [ion binding]; other site
485915002985	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
485915002986	synthetase active site [active]
485915002987	NTP binding site [chemical binding]; other site
485915002988	metal binding site [ion binding]; metal-binding site
485915002989	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
485915002990	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
485915002991	Rubredoxin [Energy production and conversion]; Region: COG1773
485915002992	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
485915002993	iron binding site [ion binding]; other site
485915002994	Response regulator receiver domain; Region: Response_reg; pfam00072
485915002995	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915002996	active site
485915002997	phosphorylation site [posttranslational modification]
485915002998	intermolecular recognition site; other site
485915002999	dimerization interface [polypeptide binding]; other site
485915003000	GAF domain; Region: GAF_3; pfam13492
485915003001	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
485915003002	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
485915003003	Zn2+ binding site [ion binding]; other site
485915003004	Mg2+ binding site [ion binding]; other site
485915003005	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
485915003006	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
485915003007	TPR motif; other site
485915003008	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
485915003009	DNA protecting protein DprA; Region: dprA; TIGR00732
485915003010	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
485915003011	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
485915003012	active site
485915003013	DNA binding site [nucleotide binding]
485915003014	Int/Topo IB signature motif; other site
485915003015	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
485915003016	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
485915003017	minor groove reading motif; other site
485915003018	helix-hairpin-helix signature motif; other site
485915003019	substrate binding pocket [chemical binding]; other site
485915003020	active site
485915003021	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
485915003022	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
485915003023	active site
485915003024	8-oxo-dGMP binding site [chemical binding]; other site
485915003025	nudix motif; other site
485915003026	metal binding site [ion binding]; metal-binding site
485915003027	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
485915003028	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915003029	Walker A/P-loop; other site
485915003030	ATP binding site [chemical binding]; other site
485915003031	Q-loop/lid; other site
485915003032	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
485915003033	ABC transporter; Region: ABC_tran_2; pfam12848
485915003034	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
485915003035	HPP family; Region: HPP; pfam04982
485915003036	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
485915003037	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
485915003038	molybdopterin cofactor binding site; other site
485915003039	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
485915003040	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
485915003041	molybdopterin cofactor binding site; other site
485915003042	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
485915003043	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
485915003044	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
485915003045	active site
485915003046	DNA binding site [nucleotide binding]
485915003047	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
485915003048	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
485915003049	Catalytic site [active]
485915003050	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
485915003051	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
485915003052	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915003053	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915003054	metal binding site [ion binding]; metal-binding site
485915003055	active site
485915003056	I-site; other site
485915003057	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
485915003058	zinc transporter ZupT; Provisional; Region: PRK04201
485915003059	ZIP Zinc transporter; Region: Zip; pfam02535
485915003060	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
485915003061	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
485915003062	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
485915003063	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
485915003064	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
485915003065	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
485915003066	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
485915003067	active site
485915003068	catalytic site [active]
485915003069	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
485915003070	PIN domain; Region: PIN_Smg5-Smg6-like; cd09880
485915003071	putative active site [active]
485915003072	PhoH-like protein; Region: PhoH; pfam02562
485915003073	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
485915003074	Cupin domain; Region: Cupin_2; pfam07883
485915003075	Transcriptional regulator [Transcription]; Region: IclR; COG1414
485915003076	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
485915003077	Sulfatase; Region: Sulfatase; cl17466
485915003078	choline-sulfatase; Region: chol_sulfatase; TIGR03417
485915003079	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
485915003080	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
485915003081	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915003082	FeS/SAM binding site; other site
485915003083	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
485915003084	L-aspartate oxidase; Provisional; Region: PRK06175
485915003085	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
485915003086	Predicted oxidoreductase [General function prediction only]; Region: COG3573
485915003087	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
485915003088	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
485915003089	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
485915003090	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
485915003091	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
485915003092	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
485915003093	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
485915003094	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
485915003095	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
485915003096	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
485915003097	Transcriptional regulators [Transcription]; Region: FadR; COG2186
485915003098	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
485915003099	DNA-binding site [nucleotide binding]; DNA binding site
485915003100	PAS fold; Region: PAS; pfam00989
485915003101	EamA-like transporter family; Region: EamA; cl17759
485915003102	EamA-like transporter family; Region: EamA; cl17759
485915003103	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
485915003104	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
485915003105	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
485915003106	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
485915003107	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
485915003108	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
485915003109	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
485915003110	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
485915003111	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
485915003112	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
485915003113	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915003114	dimer interface [polypeptide binding]; other site
485915003115	phosphorylation site [posttranslational modification]
485915003116	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915003117	ATP binding site [chemical binding]; other site
485915003118	Mg2+ binding site [ion binding]; other site
485915003119	G-X-G motif; other site
485915003120	Response regulator receiver domain; Region: Response_reg; pfam00072
485915003121	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915003122	active site
485915003123	phosphorylation site [posttranslational modification]
485915003124	intermolecular recognition site; other site
485915003125	dimerization interface [polypeptide binding]; other site
485915003126	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
485915003127	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
485915003128	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
485915003129	dimer interface [polypeptide binding]; other site
485915003130	putative CheW interface [polypeptide binding]; other site
485915003131	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
485915003132	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915003133	active site
485915003134	phosphorylation site [posttranslational modification]
485915003135	intermolecular recognition site; other site
485915003136	dimerization interface [polypeptide binding]; other site
485915003137	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915003138	Walker A motif; other site
485915003139	ATP binding site [chemical binding]; other site
485915003140	Walker B motif; other site
485915003141	arginine finger; other site
485915003142	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
485915003143	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
485915003144	PAS domain; Region: PAS_9; pfam13426
485915003145	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915003146	putative active site [active]
485915003147	heme pocket [chemical binding]; other site
485915003148	PAS domain S-box; Region: sensory_box; TIGR00229
485915003149	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915003150	putative active site [active]
485915003151	heme pocket [chemical binding]; other site
485915003152	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
485915003153	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915003154	dimer interface [polypeptide binding]; other site
485915003155	phosphorylation site [posttranslational modification]
485915003156	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915003157	ATP binding site [chemical binding]; other site
485915003158	Mg2+ binding site [ion binding]; other site
485915003159	G-X-G motif; other site
485915003160	Response regulator receiver domain; Region: Response_reg; pfam00072
485915003161	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915003162	active site
485915003163	phosphorylation site [posttranslational modification]
485915003164	intermolecular recognition site; other site
485915003165	dimerization interface [polypeptide binding]; other site
485915003166	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
485915003167	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
485915003168	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
485915003169	DNA-binding site [nucleotide binding]; DNA binding site
485915003170	Transcriptional regulators [Transcription]; Region: FadR; COG2186
485915003171	FCD domain; Region: FCD; pfam07729
485915003172	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
485915003173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
485915003174	putative substrate translocation pore; other site
485915003175	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
485915003176	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
485915003177	multicopper oxidase; Provisional; Region: PRK10965
485915003178	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
485915003179	Multicopper oxidase; Region: Cu-oxidase; pfam00394
485915003180	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
485915003181	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; pfam07355
485915003182	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
485915003183	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
485915003184	DNA binding residues [nucleotide binding]
485915003185	putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311
485915003186	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915003187	FeS/SAM binding site; other site
485915003188	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
485915003189	Methyltransferase domain; Region: Methyltransf_31; pfam13847
485915003190	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915003191	S-adenosylmethionine binding site [chemical binding]; other site
485915003192	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
485915003193	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
485915003194	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
485915003195	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
485915003196	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
485915003197	active site
485915003198	Int/Topo IB signature motif; other site
485915003199	catalytic residues [active]
485915003200	DNA binding site [nucleotide binding]
485915003201	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
485915003202	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
485915003203	active site
485915003204	catalytic residues [active]
485915003205	DNA binding site [nucleotide binding]
485915003206	Int/Topo IB signature motif; other site
485915003207	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
485915003208	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
485915003209	putative active site [active]
485915003210	putative NTP binding site [chemical binding]; other site
485915003211	putative nucleic acid binding site [nucleotide binding]; other site
485915003212	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
485915003213	seryl-tRNA synthetase; Provisional; Region: PRK05431
485915003214	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
485915003215	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
485915003216	dimer interface [polypeptide binding]; other site
485915003217	active site
485915003218	motif 1; other site
485915003219	motif 2; other site
485915003220	motif 3; other site
485915003221	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
485915003222	GAF domain; Region: GAF; cl17456
485915003223	sensory histidine kinase AtoS; Provisional; Region: PRK11360
485915003224	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915003225	dimer interface [polypeptide binding]; other site
485915003226	phosphorylation site [posttranslational modification]
485915003227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915003228	ATP binding site [chemical binding]; other site
485915003229	Mg2+ binding site [ion binding]; other site
485915003230	G-X-G motif; other site
485915003231	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
485915003232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915003233	active site
485915003234	phosphorylation site [posttranslational modification]
485915003235	intermolecular recognition site; other site
485915003236	dimerization interface [polypeptide binding]; other site
485915003237	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915003238	Walker A motif; other site
485915003239	ATP binding site [chemical binding]; other site
485915003240	Walker B motif; other site
485915003241	arginine finger; other site
485915003242	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915003243	Competence-damaged protein; Region: CinA; pfam02464
485915003244	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
485915003245	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
485915003246	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
485915003247	Protein of unknown function (DUF1614); Region: DUF1614; pfam07758
485915003248	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
485915003249	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
485915003250	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915003251	Walker A/P-loop; other site
485915003252	ATP binding site [chemical binding]; other site
485915003253	Q-loop/lid; other site
485915003254	ABC transporter signature motif; other site
485915003255	Walker B; other site
485915003256	D-loop; other site
485915003257	H-loop/switch region; other site
485915003258	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
485915003259	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
485915003260	putative active site [active]
485915003261	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
485915003262	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
485915003263	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
485915003264	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
485915003265	active site
485915003266	motif I; other site
485915003267	motif II; other site
485915003268	Domain of unknown function DUF21; Region: DUF21; pfam01595
485915003269	FOG: CBS domain [General function prediction only]; Region: COG0517
485915003270	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
485915003271	CcmE; Region: CcmE; cl00994
485915003272	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
485915003273	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
485915003274	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915003275	Walker A/P-loop; other site
485915003276	ATP binding site [chemical binding]; other site
485915003277	Q-loop/lid; other site
485915003278	ABC transporter signature motif; other site
485915003279	Walker B; other site
485915003280	D-loop; other site
485915003281	H-loop/switch region; other site
485915003282	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
485915003283	TPR repeat; Region: TPR_11; pfam13414
485915003284	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915003285	binding surface
485915003286	TPR motif; other site
485915003287	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
485915003288	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
485915003289	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
485915003290	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
485915003291	active site
485915003292	GMP synthase; Reviewed; Region: guaA; PRK00074
485915003293	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
485915003294	AMP/PPi binding site [chemical binding]; other site
485915003295	candidate oxyanion hole; other site
485915003296	catalytic triad [active]
485915003297	potential glutamine specificity residues [chemical binding]; other site
485915003298	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
485915003299	ATP Binding subdomain [chemical binding]; other site
485915003300	Ligand Binding sites [chemical binding]; other site
485915003301	Dimerization subdomain; other site
485915003302	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
485915003303	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
485915003304	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
485915003305	4-fold oligomerization interface [polypeptide binding]; other site
485915003306	putative active site pocket [active]
485915003307	metal binding residues [ion binding]; metal-binding site
485915003308	3-fold/trimer interface [polypeptide binding]; other site
485915003309	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
485915003310	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
485915003311	catalytic residues [active]
485915003312	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
485915003313	metal-binding site [ion binding]
485915003314	uracil-xanthine permease; Region: ncs2; TIGR00801
485915003315	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
485915003316	active site
485915003317	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
485915003318	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
485915003319	RNA binding surface [nucleotide binding]; other site
485915003320	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
485915003321	active site
485915003322	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
485915003323	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
485915003324	CoA-binding site [chemical binding]; other site
485915003325	ATP-binding [chemical binding]; other site
485915003326	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
485915003327	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
485915003328	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
485915003329	Walker A/P-loop; other site
485915003330	ATP binding site [chemical binding]; other site
485915003331	Q-loop/lid; other site
485915003332	ABC transporter signature motif; other site
485915003333	Walker B; other site
485915003334	D-loop; other site
485915003335	H-loop/switch region; other site
485915003336	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
485915003337	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
485915003338	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
485915003339	Transposase; Region: DDE_Tnp_ISL3; pfam01610
485915003340	putative transposase OrfB; Reviewed; Region: PHA02517
485915003341	HTH-like domain; Region: HTH_21; pfam13276
485915003342	Integrase core domain; Region: rve; pfam00665
485915003343	Integrase core domain; Region: rve_3; pfam13683
485915003344	Helix-turn-helix domain; Region: HTH_28; pfam13518
485915003345	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
485915003346	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
485915003347	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
485915003348	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
485915003349	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
485915003350	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
485915003351	active site
485915003352	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
485915003353	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
485915003354	dimer interface [polypeptide binding]; other site
485915003355	putative CheW interface [polypeptide binding]; other site
485915003356	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
485915003357	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
485915003358	ABC transporter ATPase component; Reviewed; Region: PRK11147
485915003359	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915003360	Walker A/P-loop; other site
485915003361	ATP binding site [chemical binding]; other site
485915003362	Q-loop/lid; other site
485915003363	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
485915003364	ABC transporter signature motif; other site
485915003365	Walker B; other site
485915003366	D-loop; other site
485915003367	ABC transporter; Region: ABC_tran_2; pfam12848
485915003368	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
485915003369	Pantoate-beta-alanine ligase; Region: PanC; cd00560
485915003370	pantoate--beta-alanine ligase; Region: panC; TIGR00018
485915003371	active site
485915003372	ATP-binding site [chemical binding]; other site
485915003373	pantoate-binding site; other site
485915003374	HXXH motif; other site
485915003375	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
485915003376	tetramerization interface [polypeptide binding]; other site
485915003377	active site
485915003378	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
485915003379	oligomerization interface [polypeptide binding]; other site
485915003380	active site
485915003381	metal binding site [ion binding]; metal-binding site
485915003382	transposase/IS protein; Provisional; Region: PRK09183
485915003383	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915003384	Walker A motif; other site
485915003385	ATP binding site [chemical binding]; other site
485915003386	Walker B motif; other site
485915003387	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
485915003388	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
485915003389	Integrase core domain; Region: rve; pfam00665
485915003390	PilZ domain; Region: PilZ; pfam07238
485915003391	V4R domain; Region: V4R; cl15268
485915003392	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
485915003393	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
485915003394	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
485915003395	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
485915003396	Zn2+ binding site [ion binding]; other site
485915003397	Mg2+ binding site [ion binding]; other site
485915003398	hypothetical protein; Provisional; Region: PRK08317
485915003399	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915003400	S-adenosylmethionine binding site [chemical binding]; other site
485915003401	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
485915003402	Cation efflux family; Region: Cation_efflux; pfam01545
485915003403	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
485915003404	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
485915003405	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
485915003406	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
485915003407	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
485915003408	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
485915003409	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
485915003410	dimer interface [polypeptide binding]; other site
485915003411	active site residues [active]
485915003412	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
485915003413	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
485915003414	heme-binding residues [chemical binding]; other site
485915003415	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
485915003416	Cysteine-rich domain; Region: CCG; pfam02754
485915003417	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
485915003418	FOG: WD40 repeat [General function prediction only]; Region: COG2319
485915003419	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
485915003420	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
485915003421	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915003422	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
485915003423	Cysteine-rich domain; Region: CCG; pfam02754
485915003424	Cysteine-rich domain; Region: CCG; pfam02754
485915003425	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
485915003426	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
485915003427	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
485915003428	DRTGG domain; Region: DRTGG; pfam07085
485915003429	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
485915003430	propionate/acetate kinase; Provisional; Region: PRK12379
485915003431	phosphate acetyltransferase; Reviewed; Region: PRK05632
485915003432	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
485915003433	DRTGG domain; Region: DRTGG; pfam07085
485915003434	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
485915003435	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
485915003436	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
485915003437	dimer interface [polypeptide binding]; other site
485915003438	PYR/PP interface [polypeptide binding]; other site
485915003439	TPP binding site [chemical binding]; other site
485915003440	substrate binding site [chemical binding]; other site
485915003441	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
485915003442	Domain of unknown function; Region: EKR; pfam10371
485915003443	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915003444	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
485915003445	TPP-binding site [chemical binding]; other site
485915003446	dimer interface [polypeptide binding]; other site
485915003447	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915003448	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
485915003449	Cysteine-rich domain; Region: CCG; pfam02754
485915003450	Cysteine-rich domain; Region: CCG; pfam02754
485915003451	FAD binding domain; Region: FAD_binding_4; pfam01565
485915003452	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
485915003453	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
485915003454	L-lactate permease; Region: Lactate_perm; cl00701
485915003455	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
485915003456	MarR family; Region: MarR_2; pfam12802
485915003457	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
485915003458	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
485915003459	oligomer interface [polypeptide binding]; other site
485915003460	metal binding site [ion binding]; metal-binding site
485915003461	metal binding site [ion binding]; metal-binding site
485915003462	Cl binding site [ion binding]; other site
485915003463	aspartate ring; other site
485915003464	basic sphincter; other site
485915003465	putative hydrophobic gate; other site
485915003466	periplasmic entrance; other site
485915003467	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
485915003468	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
485915003469	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
485915003470	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
485915003471	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
485915003472	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
485915003473	PhoU domain; Region: PhoU; pfam01895
485915003474	PhoU domain; Region: PhoU; pfam01895
485915003475	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
485915003476	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
485915003477	inhibitor-cofactor binding pocket; inhibition site
485915003478	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915003479	catalytic residue [active]
485915003480	AAA domain; Region: AAA_26; pfam13500
485915003481	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
485915003482	biotin synthase; Region: bioB; TIGR00433
485915003483	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915003484	FeS/SAM binding site; other site
485915003485	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
485915003486	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
485915003487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915003488	S-adenosylmethionine binding site [chemical binding]; other site
485915003489	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
485915003490	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
485915003491	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
485915003492	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
485915003493	catalytic residue [active]
485915003494	Protein of unknown function DUF89; Region: DUF89; cl15397
485915003495	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
485915003496	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
485915003497	ATP binding site [chemical binding]; other site
485915003498	putative Mg++ binding site [ion binding]; other site
485915003499	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
485915003500	nucleotide binding region [chemical binding]; other site
485915003501	ATP-binding site [chemical binding]; other site
485915003502	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
485915003503	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
485915003504	BCCT family transporter; Region: BCCT; pfam02028
485915003505	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
485915003506	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
485915003507	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
485915003508	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
485915003509	active site residue [active]
485915003510	LysE type translocator; Region: LysE; cl00565
485915003511	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
485915003512	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
485915003513	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
485915003514	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
485915003515	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
485915003516	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
485915003517	active site
485915003518	metal binding site [ion binding]; metal-binding site
485915003519	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
485915003520	putative catalytic site [active]
485915003521	putative metal binding site [ion binding]; other site
485915003522	putative phosphate binding site [ion binding]; other site
485915003523	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
485915003524	Iron-sulfur protein interface; other site
485915003525	proximal heme binding site [chemical binding]; other site
485915003526	fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626
485915003527	L-aspartate oxidase; Provisional; Region: PRK06175
485915003528	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
485915003529	fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552
485915003530	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
485915003531	fumarate hydratase; Provisional; Region: PRK06246
485915003532	Fumarase C-terminus; Region: Fumerase_C; cl00795
485915003533	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
485915003534	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
485915003535	putative active site [active]
485915003536	putative NTP binding site [chemical binding]; other site
485915003537	putative nucleic acid binding site [nucleotide binding]; other site
485915003538	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
485915003539	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
485915003540	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
485915003541	catalytic site [active]
485915003542	subunit interface [polypeptide binding]; other site
485915003543	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
485915003544	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
485915003545	Ligand binding site; other site
485915003546	oligomer interface; other site
485915003547	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
485915003548	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
485915003549	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
485915003550	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
485915003551	ATP-grasp domain; Region: ATP-grasp_4; cl17255
485915003552	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
485915003553	Zn2+ binding site [ion binding]; other site
485915003554	Mg2+ binding site [ion binding]; other site
485915003555	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
485915003556	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
485915003557	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
485915003558	dimerization interface [polypeptide binding]; other site
485915003559	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
485915003560	ATP binding site [chemical binding]; other site
485915003561	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
485915003562	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
485915003563	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
485915003564	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
485915003565	FMN binding site [chemical binding]; other site
485915003566	active site
485915003567	catalytic residues [active]
485915003568	substrate binding site [chemical binding]; other site
485915003569	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
485915003570	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
485915003571	Ligand Binding Site [chemical binding]; other site
485915003572	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
485915003573	chaperone protein DnaJ; Provisional; Region: PRK14301
485915003574	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
485915003575	HSP70 interaction site [polypeptide binding]; other site
485915003576	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
485915003577	substrate binding site [polypeptide binding]; other site
485915003578	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
485915003579	Zn binding sites [ion binding]; other site
485915003580	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
485915003581	dimer interface [polypeptide binding]; other site
485915003582	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
485915003583	dimer interface [polypeptide binding]; other site
485915003584	putative active site [active]
485915003585	trimer interface [polypeptide binding]; other site
485915003586	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
485915003587	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
485915003588	substrate binding site [chemical binding]; other site
485915003589	glutamase interaction surface [polypeptide binding]; other site
485915003590	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
485915003591	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
485915003592	putative active site [active]
485915003593	oxyanion strand; other site
485915003594	catalytic triad [active]
485915003595	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
485915003596	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
485915003597	NADP binding site [chemical binding]; other site
485915003598	homopentamer interface [polypeptide binding]; other site
485915003599	substrate binding site [chemical binding]; other site
485915003600	active site
485915003601	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
485915003602	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915003603	ATP binding site [chemical binding]; other site
485915003604	Mg2+ binding site [ion binding]; other site
485915003605	G-X-G motif; other site
485915003606	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
485915003607	ATP binding site [chemical binding]; other site
485915003608	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
485915003609	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
485915003610	Organic solvent tolerance protein; Region: OstA_C; pfam04453
485915003611	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
485915003612	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
485915003613	Walker A/P-loop; other site
485915003614	ATP binding site [chemical binding]; other site
485915003615	Q-loop/lid; other site
485915003616	ABC transporter signature motif; other site
485915003617	Walker B; other site
485915003618	D-loop; other site
485915003619	H-loop/switch region; other site
485915003620	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
485915003621	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915003622	dimer interface [polypeptide binding]; other site
485915003623	conserved gate region; other site
485915003624	putative PBP binding loops; other site
485915003625	ABC-ATPase subunit interface; other site
485915003626	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
485915003627	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
485915003628	substrate binding pocket [chemical binding]; other site
485915003629	membrane-bound complex binding site; other site
485915003630	hinge residues; other site
485915003631	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
485915003632	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
485915003633	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
485915003634	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
485915003635	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
485915003636	replicative DNA helicase; Region: DnaB; TIGR00665
485915003637	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
485915003638	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
485915003639	Walker A motif; other site
485915003640	ATP binding site [chemical binding]; other site
485915003641	Walker B motif; other site
485915003642	DNA binding loops [nucleotide binding]
485915003643	Protein of unknown function (DUF456); Region: DUF456; pfam04306
485915003644	threonine synthase; Validated; Region: PRK06260
485915003645	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
485915003646	homodimer interface [polypeptide binding]; other site
485915003647	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915003648	catalytic residue [active]
485915003649	tartrate dehydrogenase; Region: TTC; TIGR02089
485915003650	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
485915003651	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
485915003652	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
485915003653	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
485915003654	ABC transporter; Region: ABC_tran_2; pfam12848
485915003655	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
485915003656	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
485915003657	active site
485915003658	8-oxo-dGMP binding site [chemical binding]; other site
485915003659	nudix motif; other site
485915003660	metal binding site [ion binding]; metal-binding site
485915003661	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
485915003662	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
485915003663	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
485915003664	Walker A motif; other site
485915003665	ATP binding site [chemical binding]; other site
485915003666	Walker B motif; other site
485915003667	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
485915003668	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
485915003669	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
485915003670	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
485915003671	FAD binding site [chemical binding]; other site
485915003672	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
485915003673	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
485915003674	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
485915003675	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
485915003676	homodimer interface [polypeptide binding]; other site
485915003677	substrate-cofactor binding pocket; other site
485915003678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915003679	catalytic residue [active]
485915003680	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
485915003681	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
485915003682	Tim44-like domain; Region: Tim44; pfam04280
485915003683	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
485915003684	ATP binding site [chemical binding]; other site
485915003685	active site
485915003686	substrate binding site [chemical binding]; other site
485915003687	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
485915003688	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915003689	ATP binding site [chemical binding]; other site
485915003690	Mg2+ binding site [ion binding]; other site
485915003691	G-X-G motif; other site
485915003692	NIL domain; Region: NIL; pfam09383
485915003693	4Fe-4S binding domain; Region: Fer4; cl02805
485915003694	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
485915003695	4Fe-4S binding domain; Region: Fer4; pfam00037
485915003696	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
485915003697	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915003698	binding surface
485915003699	TPR motif; other site
485915003700	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
485915003701	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
485915003702	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
485915003703	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
485915003704	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
485915003705	active site
485915003706	HIGH motif; other site
485915003707	nucleotide binding site [chemical binding]; other site
485915003708	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
485915003709	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
485915003710	active site
485915003711	KMSKS motif; other site
485915003712	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
485915003713	tRNA binding surface [nucleotide binding]; other site
485915003714	anticodon binding site; other site
485915003715	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
485915003716	purine nucleoside phosphorylase; Provisional; Region: PRK08202
485915003717	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
485915003718	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
485915003719	ATP-grasp domain; Region: ATP-grasp_4; cl17255
485915003720	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
485915003721	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
485915003722	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255
485915003723	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
485915003724	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
485915003725	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
485915003726	dimer interface [polypeptide binding]; other site
485915003727	ssDNA binding site [nucleotide binding]; other site
485915003728	tetramer (dimer of dimers) interface [polypeptide binding]; other site
485915003729	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915003730	PAS fold; Region: PAS_3; pfam08447
485915003731	putative active site [active]
485915003732	heme pocket [chemical binding]; other site
485915003733	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915003734	PAS domain; Region: PAS_9; pfam13426
485915003735	putative active site [active]
485915003736	heme pocket [chemical binding]; other site
485915003737	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915003738	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915003739	metal binding site [ion binding]; metal-binding site
485915003740	active site
485915003741	I-site; other site
485915003742	amphi-Trp domain; Region: amphi-Trp; TIGR04354
485915003743	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
485915003744	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
485915003745	P-loop; other site
485915003746	Magnesium ion binding site [ion binding]; other site
485915003747	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
485915003748	Magnesium ion binding site [ion binding]; other site
485915003749	YceG-like family; Region: YceG; pfam02618
485915003750	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
485915003751	dimerization interface [polypeptide binding]; other site
485915003752	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
485915003753	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
485915003754	FAD binding domain; Region: FAD_binding_4; pfam01565
485915003755	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
485915003756	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
485915003757	Cysteine-rich domain; Region: CCG; pfam02754
485915003758	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
485915003759	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
485915003760	acyl-activating enzyme (AAE) consensus motif; other site
485915003761	active site
485915003762	AMP binding site [chemical binding]; other site
485915003763	CoA binding site [chemical binding]; other site
485915003764	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
485915003765	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
485915003766	Walker A/P-loop; other site
485915003767	ATP binding site [chemical binding]; other site
485915003768	Q-loop/lid; other site
485915003769	ABC transporter signature motif; other site
485915003770	Walker B; other site
485915003771	D-loop; other site
485915003772	H-loop/switch region; other site
485915003773	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
485915003774	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
485915003775	Walker A/P-loop; other site
485915003776	ATP binding site [chemical binding]; other site
485915003777	Q-loop/lid; other site
485915003778	ABC transporter signature motif; other site
485915003779	Walker B; other site
485915003780	D-loop; other site
485915003781	H-loop/switch region; other site
485915003782	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
485915003783	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
485915003784	TM-ABC transporter signature motif; other site
485915003785	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
485915003786	TM-ABC transporter signature motif; other site
485915003787	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
485915003788	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
485915003789	ACT domain-containing protein [General function prediction only]; Region: COG4747
485915003790	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
485915003791	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
485915003792	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
485915003793	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
485915003794	acyl-activating enzyme (AAE) consensus motif; other site
485915003795	AMP binding site [chemical binding]; other site
485915003796	active site
485915003797	CoA binding site [chemical binding]; other site
485915003798	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
485915003799	phosphoglyceromutase; Provisional; Region: PRK05434
485915003800	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
485915003801	Uncharacterized archaeal Zn-finger protein [General function prediction only]; Region: COG1326
485915003802	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
485915003803	EamA-like transporter family; Region: EamA; pfam00892
485915003804	EamA-like transporter family; Region: EamA; pfam00892
485915003805	aspartate aminotransferase; Provisional; Region: PRK05764
485915003806	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
485915003807	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915003808	homodimer interface [polypeptide binding]; other site
485915003809	catalytic residue [active]
485915003810	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
485915003811	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
485915003812	Ligand Binding Site [chemical binding]; other site
485915003813	hypothetical protein; Provisional; Region: PRK09256
485915003814	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
485915003815	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
485915003816	active site
485915003817	metal binding site [ion binding]; metal-binding site
485915003818	DNA binding site [nucleotide binding]
485915003819	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915003820	AAA domain; Region: AAA_27; pfam13514
485915003821	Walker A/P-loop; other site
485915003822	ATP binding site [chemical binding]; other site
485915003823	Methyltransferase domain; Region: Methyltransf_23; pfam13489
485915003824	Methyltransferase domain; Region: Methyltransf_11; pfam08241
485915003825	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
485915003826	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
485915003827	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
485915003828	catalytic residue [active]
485915003829	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915003830	PAS fold; Region: PAS_3; pfam08447
485915003831	putative active site [active]
485915003832	heme pocket [chemical binding]; other site
485915003833	Sensory domain found in PocR; Region: PocR; pfam10114
485915003834	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
485915003835	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915003836	dimer interface [polypeptide binding]; other site
485915003837	phosphorylation site [posttranslational modification]
485915003838	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915003839	ATP binding site [chemical binding]; other site
485915003840	Mg2+ binding site [ion binding]; other site
485915003841	G-X-G motif; other site
485915003842	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915003843	active site
485915003844	phosphorylation site [posttranslational modification]
485915003845	intermolecular recognition site; other site
485915003846	dimerization interface [polypeptide binding]; other site
485915003847	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
485915003848	PAS domain S-box; Region: sensory_box; TIGR00229
485915003849	PAS domain; Region: PAS_8; pfam13188
485915003850	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
485915003851	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915003852	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915003853	metal binding site [ion binding]; metal-binding site
485915003854	active site
485915003855	I-site; other site
485915003856	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
485915003857	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915003858	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
485915003859	Walker A motif; other site
485915003860	ATP binding site [chemical binding]; other site
485915003861	Walker B motif; other site
485915003862	arginine finger; other site
485915003863	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
485915003864	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
485915003865	ligand binding site [chemical binding]; other site
485915003866	TPR repeat; Region: TPR_11; pfam13414
485915003867	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915003868	binding surface
485915003869	TPR motif; other site
485915003870	TPR repeat; Region: TPR_11; pfam13414
485915003871	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915003872	binding surface
485915003873	TPR motif; other site
485915003874	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
485915003875	Sporulation related domain; Region: SPOR; pfam05036
485915003876	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
485915003877	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
485915003878	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915003879	TPR motif; other site
485915003880	binding surface
485915003881	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915003882	binding surface
485915003883	TPR motif; other site
485915003884	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915003885	binding surface
485915003886	TPR motif; other site
485915003887	TPR repeat; Region: TPR_11; pfam13414
485915003888	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
485915003889	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
485915003890	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
485915003891	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
485915003892	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
485915003893	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
485915003894	ATP binding site [chemical binding]; other site
485915003895	Walker A motif; other site
485915003896	hexamer interface [polypeptide binding]; other site
485915003897	Walker B motif; other site
485915003898	AAA domain; Region: AAA_31; pfam13614
485915003899	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
485915003900	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
485915003901	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
485915003902	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
485915003903	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
485915003904	TadE-like protein; Region: TadE; pfam07811
485915003905	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
485915003906	TadE-like protein; Region: TadE; pfam07811
485915003907	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
485915003908	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
485915003909	BON domain; Region: BON; pfam04972
485915003910	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
485915003911	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
485915003912	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
485915003913	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
485915003914	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
485915003915	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
485915003916	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
485915003917	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
485915003918	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
485915003919	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
485915003920	Ligand binding site; other site
485915003921	Putative Catalytic site; other site
485915003922	DXD motif; other site
485915003923	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
485915003924	Transposase; Region: DDE_Tnp_ISL3; pfam01610
485915003925	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
485915003926	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
485915003927	Integrase core domain; Region: rve; pfam00665
485915003928	transposase/IS protein; Provisional; Region: PRK09183
485915003929	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915003930	Walker A motif; other site
485915003931	ATP binding site [chemical binding]; other site
485915003932	Walker B motif; other site
485915003933	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
485915003934	Transposase; Region: DDE_Tnp_ISL3; pfam01610
485915003935	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
485915003936	Predicted membrane protein [Function unknown]; Region: COG3463
485915003937	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
485915003938	Ligand binding site; other site
485915003939	Putative Catalytic site; other site
485915003940	DXD motif; other site
485915003941	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
485915003942	Glycogen synthase [Carbohydrate transport and metabolism]; Region: GlgA; COG0297
485915003943	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
485915003944	Response regulator receiver domain; Region: Response_reg; pfam00072
485915003945	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915003946	active site
485915003947	phosphorylation site [posttranslational modification]
485915003948	intermolecular recognition site; other site
485915003949	dimerization interface [polypeptide binding]; other site
485915003950	PAS fold; Region: PAS_4; pfam08448
485915003951	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915003952	putative active site [active]
485915003953	heme pocket [chemical binding]; other site
485915003954	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915003955	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915003956	metal binding site [ion binding]; metal-binding site
485915003957	active site
485915003958	I-site; other site
485915003959	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
485915003960	HDOD domain; Region: HDOD; pfam08668
485915003961	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
485915003962	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915003963	dimer interface [polypeptide binding]; other site
485915003964	phosphorylation site [posttranslational modification]
485915003965	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915003966	ATP binding site [chemical binding]; other site
485915003967	Mg2+ binding site [ion binding]; other site
485915003968	G-X-G motif; other site
485915003969	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
485915003970	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
485915003971	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
485915003972	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
485915003973	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
485915003974	TrkA-N domain; Region: TrkA_N; pfam02254
485915003975	Protein of unknown function (DUF1318); Region: DUF1318; cl01547
485915003976	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
485915003977	Dicarboxylate transport; Region: DctA-YdbH; cl14674
485915003978	Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945
485915003979	Membrane transport protein; Region: Mem_trans; cl09117
485915003980	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
485915003981	Fe-S cluster binding site [ion binding]; other site
485915003982	active site
485915003983	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
485915003984	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915003985	PAS domain; Region: PAS_9; pfam13426
485915003986	putative active site [active]
485915003987	heme pocket [chemical binding]; other site
485915003988	PAS domain; Region: PAS_9; pfam13426
485915003989	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915003990	putative active site [active]
485915003991	heme pocket [chemical binding]; other site
485915003992	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915003993	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915003994	metal binding site [ion binding]; metal-binding site
485915003995	active site
485915003996	I-site; other site
485915003997	Domain of unknown function DUF302; Region: DUF302; cl01364
485915003998	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
485915003999	Sodium Bile acid symporter family; Region: SBF; pfam01758
485915004000	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
485915004001	Ligand Binding Site [chemical binding]; other site
485915004002	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
485915004003	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
485915004004	catalytic residues [active]
485915004005	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915004006	PAS domain; Region: PAS_9; pfam13426
485915004007	putative active site [active]
485915004008	heme pocket [chemical binding]; other site
485915004009	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
485915004010	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915004011	Walker A motif; other site
485915004012	ATP binding site [chemical binding]; other site
485915004013	Walker B motif; other site
485915004014	arginine finger; other site
485915004015	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915004016	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
485915004017	substrate binding site [chemical binding]; other site
485915004018	Domain of unknown function (DUF362); Region: DUF362; pfam04015
485915004019	Ferredoxin [Energy production and conversion]; Region: COG1146
485915004020	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
485915004021	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
485915004022	putative FMN binding site [chemical binding]; other site
485915004023	Rubrerythrin [Energy production and conversion]; Region: COG1592
485915004024	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
485915004025	binuclear metal center [ion binding]; other site
485915004026	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
485915004027	iron binding site [ion binding]; other site
485915004028	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
485915004029	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
485915004030	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
485915004031	active site
485915004032	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
485915004033	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
485915004034	homodimer interface [polypeptide binding]; other site
485915004035	substrate-cofactor binding pocket; other site
485915004036	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915004037	catalytic residue [active]
485915004038	selenobiotic family peptide radical SAM maturase; Region: rSAM_for_selen; TIGR04082
485915004039	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915004040	FeS/SAM binding site; other site
485915004041	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
485915004042	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
485915004043	Uncharacterized conserved protein [Function unknown]; Region: COG1359
485915004044	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
485915004045	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
485915004046	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915004047	FeS/SAM binding site; other site
485915004048	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
485915004049	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
485915004050	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
485915004051	GAF domain; Region: GAF_2; pfam13185
485915004052	GAF domain; Region: GAF_3; pfam13492
485915004053	sensory histidine kinase AtoS; Provisional; Region: PRK11360
485915004054	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915004055	dimer interface [polypeptide binding]; other site
485915004056	phosphorylation site [posttranslational modification]
485915004057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915004058	ATP binding site [chemical binding]; other site
485915004059	Mg2+ binding site [ion binding]; other site
485915004060	G-X-G motif; other site
485915004061	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
485915004062	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915004063	active site
485915004064	phosphorylation site [posttranslational modification]
485915004065	intermolecular recognition site; other site
485915004066	dimerization interface [polypeptide binding]; other site
485915004067	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915004068	Walker A motif; other site
485915004069	ATP binding site [chemical binding]; other site
485915004070	Walker B motif; other site
485915004071	arginine finger; other site
485915004072	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915004073	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
485915004074	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
485915004075	Cation efflux family; Region: Cation_efflux; pfam01545
485915004076	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
485915004077	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
485915004078	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
485915004079	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
485915004080	putative MPT binding site; other site
485915004081	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
485915004082	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
485915004083	4Fe-4S binding domain; Region: Fer4; cl02805
485915004084	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
485915004085	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
485915004086	putative [4Fe-4S] binding site [ion binding]; other site
485915004087	putative molybdopterin cofactor binding site [chemical binding]; other site
485915004088	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
485915004089	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
485915004090	PAS domain; Region: PAS; smart00091
485915004091	PAS fold; Region: PAS_4; pfam08448
485915004092	putative active site [active]
485915004093	heme pocket [chemical binding]; other site
485915004094	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
485915004095	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
485915004096	DNA binding residues [nucleotide binding]
485915004097	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
485915004098	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
485915004099	ligand binding site [chemical binding]; other site
485915004100	flexible hinge region; other site
485915004101	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
485915004102	putative switch regulator; other site
485915004103	non-specific DNA interactions [nucleotide binding]; other site
485915004104	DNA binding site [nucleotide binding]
485915004105	sequence specific DNA binding site [nucleotide binding]; other site
485915004106	putative cAMP binding site [chemical binding]; other site
485915004107	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
485915004108	ACS interaction site; other site
485915004109	CODH interaction site; other site
485915004110	Prismane/CO dehydrogenase family; Region: Prismane; pfam03063
485915004111	cubane metal cluster (B-cluster) [ion binding]; other site
485915004112	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
485915004113	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
485915004114	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
485915004115	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
485915004116	tetramer interface [polypeptide binding]; other site
485915004117	heme binding pocket [chemical binding]; other site
485915004118	NADPH binding site [chemical binding]; other site
485915004119	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
485915004120	Protein of unknown function (DUF1365); Region: DUF1365; cl17838
485915004121	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
485915004122	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915004123	S-adenosylmethionine binding site [chemical binding]; other site
485915004124	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
485915004125	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
485915004126	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
485915004127	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915004128	S-adenosylmethionine binding site [chemical binding]; other site
485915004129	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
485915004130	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
485915004131	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
485915004132	active site
485915004133	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
485915004134	nucleophile elbow; other site
485915004135	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
485915004136	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
485915004137	dimer interface [polypeptide binding]; other site
485915004138	catalytic triad [active]
485915004139	peroxidatic and resolving cysteines [active]
485915004140	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
485915004141	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
485915004142	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
485915004143	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
485915004144	Predicted acyl esterases [General function prediction only]; Region: COG2936
485915004145	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
485915004146	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
485915004147	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
485915004148	Predicted small secreted protein [Function unknown]; Region: COG5510
485915004149	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
485915004150	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
485915004151	active site
485915004152	metal binding site [ion binding]; metal-binding site
485915004153	DNA binding site [nucleotide binding]
485915004154	AAA domain; Region: AAA_27; pfam13514
485915004155	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
485915004156	catalytic core [active]
485915004157	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
485915004158	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
485915004159	G1 box; other site
485915004160	putative GEF interaction site [polypeptide binding]; other site
485915004161	GTP/Mg2+ binding site [chemical binding]; other site
485915004162	Switch I region; other site
485915004163	G2 box; other site
485915004164	G3 box; other site
485915004165	Switch II region; other site
485915004166	G4 box; other site
485915004167	G5 box; other site
485915004168	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
485915004169	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
485915004170	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
485915004171	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
485915004172	active site
485915004173	NAD binding site [chemical binding]; other site
485915004174	metal binding site [ion binding]; metal-binding site
485915004175	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
485915004176	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
485915004177	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
485915004178	motif II; other site
485915004179	DsrE/DsrF-like family; Region: DrsE; pfam02635
485915004180	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
485915004181	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
485915004182	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
485915004183	heme-binding residues [chemical binding]; other site
485915004184	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
485915004185	Domain of unknown function DUF20; Region: UPF0118; pfam01594
485915004186	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
485915004187	HAMP domain; Region: HAMP; pfam00672
485915004188	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915004189	PAS domain; Region: PAS_9; pfam13426
485915004190	putative active site [active]
485915004191	heme pocket [chemical binding]; other site
485915004192	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
485915004193	dimer interface [polypeptide binding]; other site
485915004194	putative CheW interface [polypeptide binding]; other site
485915004195	Tropomyosin like; Region: Tropomyosin_1; pfam12718
485915004196	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
485915004197	Peptidase family M23; Region: Peptidase_M23; pfam01551
485915004198	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
485915004199	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
485915004200	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
485915004201	EamA-like transporter family; Region: EamA; pfam00892
485915004202	EamA-like transporter family; Region: EamA; pfam00892
485915004203	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
485915004204	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
485915004205	dimerization interface [polypeptide binding]; other site
485915004206	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
485915004207	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
485915004208	ligand binding site [chemical binding]; other site
485915004209	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
485915004210	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
485915004211	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
485915004212	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
485915004213	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
485915004214	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
485915004215	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
485915004216	ligand binding site [chemical binding]; other site
485915004217	flexible hinge region; other site
485915004218	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
485915004219	putative switch regulator; other site
485915004220	non-specific DNA interactions [nucleotide binding]; other site
485915004221	DNA binding site [nucleotide binding]
485915004222	sequence specific DNA binding site [nucleotide binding]; other site
485915004223	putative cAMP binding site [chemical binding]; other site
485915004224	Ferredoxin [Energy production and conversion]; Region: COG1146
485915004225	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
485915004226	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
485915004227	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
485915004228	Acylphosphatase; Region: Acylphosphatase; pfam00708
485915004229	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
485915004230	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
485915004231	endonuclease IV; Provisional; Region: PRK01060
485915004232	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
485915004233	AP (apurinic/apyrimidinic) site pocket; other site
485915004234	DNA interaction; other site
485915004235	Metal-binding active site; metal-binding site
485915004236	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
485915004237	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
485915004238	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
485915004239	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
485915004240	ligand binding site [chemical binding]; other site
485915004241	Universal stress protein family; Region: Usp; pfam00582
485915004242	Ligand Binding Site [chemical binding]; other site
485915004243	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
485915004244	Ligand Binding Site [chemical binding]; other site
485915004245	phosphodiesterase YaeI; Provisional; Region: PRK11340
485915004246	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
485915004247	putative active site [active]
485915004248	putative metal binding site [ion binding]; other site
485915004249	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
485915004250	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
485915004251	active site
485915004252	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
485915004253	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
485915004254	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
485915004255	Walker A/P-loop; other site
485915004256	ATP binding site [chemical binding]; other site
485915004257	Q-loop/lid; other site
485915004258	ABC transporter signature motif; other site
485915004259	Walker B; other site
485915004260	D-loop; other site
485915004261	H-loop/switch region; other site
485915004262	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915004263	binding surface
485915004264	Tetratricopeptide repeat; Region: TPR_16; pfam13432
485915004265	TPR motif; other site
485915004266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915004267	dimer interface [polypeptide binding]; other site
485915004268	conserved gate region; other site
485915004269	putative PBP binding loops; other site
485915004270	ABC-ATPase subunit interface; other site
485915004271	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
485915004272	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
485915004273	substrate binding pocket [chemical binding]; other site
485915004274	membrane-bound complex binding site; other site
485915004275	hinge residues; other site
485915004276	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
485915004277	Predicted permeases [General function prediction only]; Region: COG0795
485915004278	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
485915004279	Predicted permeases [General function prediction only]; Region: COG0795
485915004280	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
485915004281	G1 box; other site
485915004282	GTP/Mg2+ binding site [chemical binding]; other site
485915004283	Switch I region; other site
485915004284	G2 box; other site
485915004285	G3 box; other site
485915004286	Switch II region; other site
485915004287	G4 box; other site
485915004288	G5 box; other site
485915004289	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
485915004290	Dehydroquinase class II; Region: DHquinase_II; pfam01220
485915004291	trimer interface [polypeptide binding]; other site
485915004292	active site
485915004293	dimer interface [polypeptide binding]; other site
485915004294	elongation factor P; Validated; Region: PRK00529
485915004295	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
485915004296	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
485915004297	RNA binding site [nucleotide binding]; other site
485915004298	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
485915004299	RNA binding site [nucleotide binding]; other site
485915004300	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
485915004301	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
485915004302	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
485915004303	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
485915004304	Acylphosphatase; Region: Acylphosphatase; pfam00708
485915004305	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
485915004306	HypF finger; Region: zf-HYPF; pfam07503
485915004307	HypF finger; Region: zf-HYPF; pfam07503
485915004308	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
485915004309	Uncharacterized conserved protein [Function unknown]; Region: COG2006
485915004310	Domain of unknown function (DUF362); Region: DUF362; pfam04015
485915004311	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
485915004312	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
485915004313	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
485915004314	dimerization interface [polypeptide binding]; other site
485915004315	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915004316	putative active site [active]
485915004317	heme pocket [chemical binding]; other site
485915004318	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915004319	ATP binding site [chemical binding]; other site
485915004320	Mg2+ binding site [ion binding]; other site
485915004321	G-X-G motif; other site
485915004322	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
485915004323	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915004324	active site
485915004325	phosphorylation site [posttranslational modification]
485915004326	intermolecular recognition site; other site
485915004327	dimerization interface [polypeptide binding]; other site
485915004328	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
485915004329	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
485915004330	putative ligand binding site [chemical binding]; other site
485915004331	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
485915004332	active site residue [active]
485915004333	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
485915004334	diiron binding motif [ion binding]; other site
485915004335	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915004336	S-adenosylmethionine binding site [chemical binding]; other site
485915004337	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
485915004338	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
485915004339	catalytic residues [active]
485915004340	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
485915004341	EamA-like transporter family; Region: EamA; pfam00892
485915004342	EamA-like transporter family; Region: EamA; pfam00892
485915004343	Deoxyhypusine synthase; Region: DS; cl00826
485915004344	deoxyhypusine synthase; Region: dhys; TIGR00321
485915004345	agmatinase; Region: agmatinase; TIGR01230
485915004346	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
485915004347	putative active site [active]
485915004348	Mn binding site [ion binding]; other site
485915004349	pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285
485915004350	Sporulation related domain; Region: SPOR; pfam05036
485915004351	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
485915004352	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
485915004353	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
485915004354	active site
485915004355	HIGH motif; other site
485915004356	KMSK motif region; other site
485915004357	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
485915004358	tRNA binding surface [nucleotide binding]; other site
485915004359	anticodon binding site; other site
485915004360	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
485915004361	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
485915004362	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
485915004363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915004364	photolyase PhrII; Region: phr2; TIGR00591
485915004365	DNA photolyase; Region: DNA_photolyase; pfam00875
485915004366	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
485915004367	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
485915004368	putative NAD(P) binding site [chemical binding]; other site
485915004369	putative active site [active]
485915004370	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
485915004371	Protein of unknown function (DUF523); Region: DUF523; pfam04463
485915004372	Uncharacterized conserved protein [Function unknown]; Region: COG3272
485915004373	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
485915004374	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
485915004375	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
485915004376	TIGR01777 family protein; Region: yfcH
485915004377	putative NAD(P) binding site [chemical binding]; other site
485915004378	putative active site [active]
485915004379	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
485915004380	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
485915004381	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
485915004382	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
485915004383	Rhomboid family; Region: Rhomboid; cl11446
485915004384	phosphoglucomutase; Validated; Region: PRK07564
485915004385	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
485915004386	active site
485915004387	substrate binding site [chemical binding]; other site
485915004388	metal binding site [ion binding]; metal-binding site
485915004389	SMUG: single-strand-selective monofunctional uracil-DNA glycosylase; Region: UDG_F3_SMUG; cd10029
485915004390	active site
485915004391	substrate specificity residue; other site
485915004392	DNA binding site [nucleotide binding]
485915004393	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
485915004394	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
485915004395	putative acyl-acceptor binding pocket; other site
485915004396	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
485915004397	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
485915004398	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
485915004399	active site
485915004400	catalytic tetrad [active]
485915004401	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
485915004402	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
485915004403	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
485915004404	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
485915004405	diaminopimelate decarboxylase; Region: lysA; TIGR01048
485915004406	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
485915004407	active site
485915004408	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
485915004409	substrate binding site [chemical binding]; other site
485915004410	catalytic residues [active]
485915004411	dimer interface [polypeptide binding]; other site
485915004412	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
485915004413	MutS domain I; Region: MutS_I; pfam01624
485915004414	MutS domain II; Region: MutS_II; pfam05188
485915004415	MutS domain III; Region: MutS_III; pfam05192
485915004416	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
485915004417	Walker A/P-loop; other site
485915004418	ATP binding site [chemical binding]; other site
485915004419	Q-loop/lid; other site
485915004420	ABC transporter signature motif; other site
485915004421	Walker B; other site
485915004422	D-loop; other site
485915004423	H-loop/switch region; other site
485915004424	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915004425	TPR motif; other site
485915004426	binding surface
485915004427	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915004428	binding surface
485915004429	TPR motif; other site
485915004430	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475
485915004431	Zn binding site [ion binding]; other site
485915004432	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
485915004433	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
485915004434	nucleotide binding site/active site [active]
485915004435	HIT family signature motif; other site
485915004436	catalytic residue [active]
485915004437	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
485915004438	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
485915004439	Walker A/P-loop; other site
485915004440	ATP binding site [chemical binding]; other site
485915004441	Q-loop/lid; other site
485915004442	ABC transporter signature motif; other site
485915004443	Walker B; other site
485915004444	D-loop; other site
485915004445	H-loop/switch region; other site
485915004446	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
485915004447	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
485915004448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915004449	dimer interface [polypeptide binding]; other site
485915004450	conserved gate region; other site
485915004451	putative PBP binding loops; other site
485915004452	ABC-ATPase subunit interface; other site
485915004453	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
485915004454	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
485915004455	substrate binding pocket [chemical binding]; other site
485915004456	membrane-bound complex binding site; other site
485915004457	hinge residues; other site
485915004458	DHH family; Region: DHH; pfam01368
485915004459	DHHA1 domain; Region: DHHA1; pfam02272
485915004460	FOG: CBS domain [General function prediction only]; Region: COG0517
485915004461	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
485915004462	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
485915004463	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
485915004464	active site
485915004465	NTP binding site [chemical binding]; other site
485915004466	metal binding triad [ion binding]; metal-binding site
485915004467	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
485915004468	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
485915004469	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
485915004470	active site
485915004471	DNA binding site [nucleotide binding]
485915004472	Int/Topo IB signature motif; other site
485915004473	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
485915004474	catalytic center binding site [active]
485915004475	ATP binding site [chemical binding]; other site
485915004476	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
485915004477	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
485915004478	active site
485915004479	intersubunit interactions; other site
485915004480	catalytic residue [active]
485915004481	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
485915004482	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
485915004483	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915004484	homodimer interface [polypeptide binding]; other site
485915004485	catalytic residue [active]
485915004486	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
485915004487	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
485915004488	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
485915004489	MgtC family; Region: MgtC; pfam02308
485915004490	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
485915004491	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
485915004492	Walker A/P-loop; other site
485915004493	ATP binding site [chemical binding]; other site
485915004494	Q-loop/lid; other site
485915004495	ABC transporter signature motif; other site
485915004496	Walker B; other site
485915004497	D-loop; other site
485915004498	H-loop/switch region; other site
485915004499	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
485915004500	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
485915004501	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
485915004502	Walker A/P-loop; other site
485915004503	ATP binding site [chemical binding]; other site
485915004504	Q-loop/lid; other site
485915004505	ABC transporter signature motif; other site
485915004506	Walker B; other site
485915004507	D-loop; other site
485915004508	H-loop/switch region; other site
485915004509	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
485915004510	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
485915004511	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
485915004512	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915004513	dimer interface [polypeptide binding]; other site
485915004514	conserved gate region; other site
485915004515	putative PBP binding loops; other site
485915004516	ABC-ATPase subunit interface; other site
485915004517	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
485915004518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915004519	dimer interface [polypeptide binding]; other site
485915004520	conserved gate region; other site
485915004521	putative PBP binding loops; other site
485915004522	ABC-ATPase subunit interface; other site
485915004523	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
485915004524	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
485915004525	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
485915004526	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
485915004527	Ligand Binding Site [chemical binding]; other site
485915004528	TIGR00269 family protein; Region: TIGR00269
485915004529	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
485915004530	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
485915004531	Clp amino terminal domain; Region: Clp_N; pfam02861
485915004532	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915004533	Walker A motif; other site
485915004534	ATP binding site [chemical binding]; other site
485915004535	Walker B motif; other site
485915004536	arginine finger; other site
485915004537	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915004538	Walker A motif; other site
485915004539	ATP binding site [chemical binding]; other site
485915004540	Walker B motif; other site
485915004541	arginine finger; other site
485915004542	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
485915004543	Uncharacterized conserved protein [Function unknown]; Region: COG2127
485915004544	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
485915004545	putative active site [active]
485915004546	putative metal binding residues [ion binding]; other site
485915004547	signature motif; other site
485915004548	putative triphosphate binding site [ion binding]; other site
485915004549	dimer interface [polypeptide binding]; other site
485915004550	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
485915004551	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
485915004552	histidinol dehydrogenase; Region: hisD; TIGR00069
485915004553	NAD binding site [chemical binding]; other site
485915004554	dimerization interface [polypeptide binding]; other site
485915004555	product binding site; other site
485915004556	substrate binding site [chemical binding]; other site
485915004557	zinc binding site [ion binding]; other site
485915004558	catalytic residues [active]
485915004559	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
485915004560	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
485915004561	dimerization interface [polypeptide binding]; other site
485915004562	active site
485915004563	quinolinate synthetase; Provisional; Region: PRK09375
485915004564	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
485915004565	L-aspartate oxidase; Provisional; Region: PRK06175
485915004566	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
485915004567	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
485915004568	putative active site [active]
485915004569	4Fe-4S binding domain; Region: Fer4_6; pfam12837
485915004570	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
485915004571	4Fe-4S binding domain; Region: Fer4; pfam00037
485915004572	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
485915004573	phosphate binding site [ion binding]; other site
485915004574	domain_subunit interface; other site
485915004575	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
485915004576	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
485915004577	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
485915004578	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
485915004579	4Fe-4S binding domain; Region: Fer4; pfam00037
485915004580	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
485915004581	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
485915004582	Na binding site [ion binding]; other site
485915004583	Protein of unknown function (DUF997); Region: DUF997; pfam06196
485915004584	Protein of unknown function DUF45; Region: DUF45; pfam01863
485915004585	Transglycosylase SLT domain; Region: SLT_2; pfam13406
485915004586	murein hydrolase B; Provisional; Region: PRK10760; cl17906
485915004587	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
485915004588	N-acetyl-D-glucosamine binding site [chemical binding]; other site
485915004589	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
485915004590	serine O-acetyltransferase; Region: cysE; TIGR01172
485915004591	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
485915004592	trimer interface [polypeptide binding]; other site
485915004593	active site
485915004594	substrate binding site [chemical binding]; other site
485915004595	CoA binding site [chemical binding]; other site
485915004596	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
485915004597	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
485915004598	active site
485915004599	HIGH motif; other site
485915004600	nucleotide binding site [chemical binding]; other site
485915004601	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
485915004602	KMSKS motif; other site
485915004603	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
485915004604	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
485915004605	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
485915004606	dimer interface [polypeptide binding]; other site
485915004607	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915004608	catalytic residue [active]
485915004609	ribonuclease III; Reviewed; Region: rnc; PRK00102
485915004610	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
485915004611	dimerization interface [polypeptide binding]; other site
485915004612	active site
485915004613	metal binding site [ion binding]; metal-binding site
485915004614	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
485915004615	dsRNA binding site [nucleotide binding]; other site
485915004616	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
485915004617	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
485915004618	ADP binding site [chemical binding]; other site
485915004619	magnesium binding site [ion binding]; other site
485915004620	putative shikimate binding site; other site
485915004621	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
485915004622	Zn2+ binding site [ion binding]; other site
485915004623	Mg2+ binding site [ion binding]; other site
485915004624	GTP-binding protein YchF; Reviewed; Region: PRK09601
485915004625	YchF GTPase; Region: YchF; cd01900
485915004626	G1 box; other site
485915004627	GTP/Mg2+ binding site [chemical binding]; other site
485915004628	Switch I region; other site
485915004629	G2 box; other site
485915004630	Switch II region; other site
485915004631	G3 box; other site
485915004632	G4 box; other site
485915004633	G5 box; other site
485915004634	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
485915004635	Domain of unknown function (DUF1992); Region: DUF1992; cl08096
485915004636	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
485915004637	anti sigma factor interaction site; other site
485915004638	regulatory phosphorylation site [posttranslational modification]; other site
485915004639	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
485915004640	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
485915004641	putative active site [active]
485915004642	dimerization interface [polypeptide binding]; other site
485915004643	putative tRNAtyr binding site [nucleotide binding]; other site
485915004644	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
485915004645	active site
485915004646	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
485915004647	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
485915004648	active site
485915004649	PHP Thumb interface [polypeptide binding]; other site
485915004650	metal binding site [ion binding]; metal-binding site
485915004651	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
485915004652	generic binding surface II; other site
485915004653	generic binding surface I; other site
485915004654	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
485915004655	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
485915004656	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
485915004657	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
485915004658	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
485915004659	intersubunit interface [polypeptide binding]; other site
485915004660	active site
485915004661	zinc binding site [ion binding]; other site
485915004662	Na+ binding site [ion binding]; other site
485915004663	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
485915004664	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
485915004665	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
485915004666	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
485915004667	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
485915004668	TPP-binding site [chemical binding]; other site
485915004669	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
485915004670	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
485915004671	dimer interface [polypeptide binding]; other site
485915004672	PYR/PP interface [polypeptide binding]; other site
485915004673	TPP binding site [chemical binding]; other site
485915004674	substrate binding site [chemical binding]; other site
485915004675	Ferredoxin [Energy production and conversion]; Region: COG1146
485915004676	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
485915004677	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
485915004678	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
485915004679	generic binding surface II; other site
485915004680	generic binding surface I; other site
485915004681	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
485915004682	Zn2+ binding site [ion binding]; other site
485915004683	Mg2+ binding site [ion binding]; other site
485915004684	thymidylate kinase; Validated; Region: tmk; PRK00698
485915004685	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
485915004686	TMP-binding site; other site
485915004687	ATP-binding site [chemical binding]; other site
485915004688	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
485915004689	catalytic residues [active]
485915004690	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
485915004691	NifU-like domain; Region: NifU; pfam01106
485915004692	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
485915004693	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
485915004694	HIGH motif; other site
485915004695	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
485915004696	active site
485915004697	KMSKS motif; other site
485915004698	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
485915004699	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
485915004700	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
485915004701	putative phosphate acyltransferase; Provisional; Region: PRK05331
485915004702	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
485915004703	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
485915004704	dimer interface [polypeptide binding]; other site
485915004705	active site
485915004706	CoA binding pocket [chemical binding]; other site
485915004707	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
485915004708	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
485915004709	NAD(P) binding site [chemical binding]; other site
485915004710	homotetramer interface [polypeptide binding]; other site
485915004711	homodimer interface [polypeptide binding]; other site
485915004712	active site
485915004713	acyl carrier protein; Provisional; Region: acpP; PRK00982
485915004714	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
485915004715	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
485915004716	dimer interface [polypeptide binding]; other site
485915004717	active site
485915004718	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
485915004719	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
485915004720	dimer interface [polypeptide binding]; other site
485915004721	active site
485915004722	glycine-pyridoxal phosphate binding site [chemical binding]; other site
485915004723	folate binding site [chemical binding]; other site
485915004724	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
485915004725	catalytic motif [active]
485915004726	Zn binding site [ion binding]; other site
485915004727	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
485915004728	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
485915004729	catalytic motif [active]
485915004730	Zn binding site [ion binding]; other site
485915004731	RibD C-terminal domain; Region: RibD_C; cl17279
485915004732	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
485915004733	Lumazine binding domain; Region: Lum_binding; pfam00677
485915004734	Lumazine binding domain; Region: Lum_binding; pfam00677
485915004735	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
485915004736	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
485915004737	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
485915004738	dimerization interface [polypeptide binding]; other site
485915004739	active site
485915004740	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
485915004741	homopentamer interface [polypeptide binding]; other site
485915004742	active site
485915004743	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
485915004744	putative RNA binding site [nucleotide binding]; other site
485915004745	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
485915004746	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
485915004747	HIGH motif; other site
485915004748	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
485915004749	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
485915004750	active site
485915004751	KMSKS motif; other site
485915004752	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
485915004753	tRNA binding surface [nucleotide binding]; other site
485915004754	Lipopolysaccharide-assembly; Region: LptE; pfam04390
485915004755	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
485915004756	hypothetical protein; Reviewed; Region: PRK00024
485915004757	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
485915004758	MPN+ (JAMM) motif; other site
485915004759	Zinc-binding site [ion binding]; other site
485915004760	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
485915004761	Found in ATP-dependent protease La (LON); Region: LON; smart00464
485915004762	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915004763	Walker A motif; other site
485915004764	ATP binding site [chemical binding]; other site
485915004765	Walker B motif; other site
485915004766	arginine finger; other site
485915004767	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
485915004768	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
485915004769	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915004770	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915004771	metal binding site [ion binding]; metal-binding site
485915004772	active site
485915004773	I-site; other site
485915004774	Uncharacterized conserved protein [Function unknown]; Region: COG3287
485915004775	FIST N domain; Region: FIST; pfam08495
485915004776	FIST C domain; Region: FIST_C; pfam10442
485915004777	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
485915004778	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
485915004779	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915004780	Walker A/P-loop; other site
485915004781	ATP binding site [chemical binding]; other site
485915004782	Q-loop/lid; other site
485915004783	ABC transporter signature motif; other site
485915004784	Walker B; other site
485915004785	D-loop; other site
485915004786	H-loop/switch region; other site
485915004787	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
485915004788	Response regulator receiver domain; Region: Response_reg; pfam00072
485915004789	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915004790	active site
485915004791	phosphorylation site [posttranslational modification]
485915004792	intermolecular recognition site; other site
485915004793	dimerization interface [polypeptide binding]; other site
485915004794	Chemotaxis phosphatase CheX; Region: CheX; cl15816
485915004795	Chemotaxis phosphatase CheX; Region: CheX; cl15816
485915004796	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915004797	PAS domain; Region: PAS_9; pfam13426
485915004798	putative active site [active]
485915004799	heme pocket [chemical binding]; other site
485915004800	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915004801	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915004802	metal binding site [ion binding]; metal-binding site
485915004803	active site
485915004804	I-site; other site
485915004805	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
485915004806	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
485915004807	translation initiation factor Sui1; Validated; Region: PRK06824
485915004808	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
485915004809	putative rRNA binding site [nucleotide binding]; other site
485915004810	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
485915004811	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
485915004812	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
485915004813	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
485915004814	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
485915004815	active site
485915004816	catalytic tetrad [active]
485915004817	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915004818	transaminase; Validated; Region: PRK07324
485915004819	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
485915004820	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915004821	homodimer interface [polypeptide binding]; other site
485915004822	catalytic residue [active]
485915004823	glutamate racemase; Provisional; Region: PRK00865
485915004824	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
485915004825	Low molecular weight phosphatase family; Region: LMWPc; cd00115
485915004826	active site
485915004827	Methyltransferase domain; Region: Methyltransf_31; pfam13847
485915004828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915004829	S-adenosylmethionine binding site [chemical binding]; other site
485915004830	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
485915004831	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
485915004832	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
485915004833	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915004834	S-adenosylmethionine binding site [chemical binding]; other site
485915004835	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
485915004836	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
485915004837	substrate binding site [chemical binding]; other site
485915004838	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
485915004839	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
485915004840	substrate binding site [chemical binding]; other site
485915004841	ligand binding site [chemical binding]; other site
485915004842	2-isopropylmalate synthase; Validated; Region: PRK00915
485915004843	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
485915004844	active site
485915004845	catalytic residues [active]
485915004846	metal binding site [ion binding]; metal-binding site
485915004847	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
485915004848	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
485915004849	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
485915004850	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
485915004851	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
485915004852	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
485915004853	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
485915004854	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
485915004855	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
485915004856	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
485915004857	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
485915004858	tRNA; other site
485915004859	putative tRNA binding site [nucleotide binding]; other site
485915004860	putative NADP binding site [chemical binding]; other site
485915004861	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
485915004862	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
485915004863	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
485915004864	Ligand Binding Site [chemical binding]; other site
485915004865	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
485915004866	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
485915004867	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
485915004868	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
485915004869	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
485915004870	DNA-binding site [nucleotide binding]; DNA binding site
485915004871	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
485915004872	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915004873	homodimer interface [polypeptide binding]; other site
485915004874	catalytic residue [active]
485915004875	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
485915004876	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
485915004877	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
485915004878	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
485915004879	N-terminal plug; other site
485915004880	ligand-binding site [chemical binding]; other site
485915004881	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
485915004882	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915004883	Walker A/P-loop; other site
485915004884	ATP binding site [chemical binding]; other site
485915004885	Q-loop/lid; other site
485915004886	ABC transporter signature motif; other site
485915004887	Walker B; other site
485915004888	D-loop; other site
485915004889	H-loop/switch region; other site
485915004890	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
485915004891	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
485915004892	Walker A/P-loop; other site
485915004893	ATP binding site [chemical binding]; other site
485915004894	Q-loop/lid; other site
485915004895	ABC transporter signature motif; other site
485915004896	Walker B; other site
485915004897	D-loop; other site
485915004898	H-loop/switch region; other site
485915004899	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
485915004900	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
485915004901	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
485915004902	ATP binding site [chemical binding]; other site
485915004903	Mg++ binding site [ion binding]; other site
485915004904	motif III; other site
485915004905	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
485915004906	nucleotide binding region [chemical binding]; other site
485915004907	ATP-binding site [chemical binding]; other site
485915004908	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
485915004909	Coenzyme A binding pocket [chemical binding]; other site
485915004910	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
485915004911	amino acid carrier protein; Region: agcS; TIGR00835
485915004912	alanine racemase; Reviewed; Region: alr; PRK00053
485915004913	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
485915004914	active site
485915004915	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
485915004916	dimer interface [polypeptide binding]; other site
485915004917	substrate binding site [chemical binding]; other site
485915004918	catalytic residues [active]
485915004919	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
485915004920	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
485915004921	hexamer interface [polypeptide binding]; other site
485915004922	ligand binding site [chemical binding]; other site
485915004923	putative active site [active]
485915004924	NAD(P) binding site [chemical binding]; other site
485915004925	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
485915004926	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
485915004927	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915004928	putative active site [active]
485915004929	heme pocket [chemical binding]; other site
485915004930	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915004931	Walker A motif; other site
485915004932	ATP binding site [chemical binding]; other site
485915004933	Walker B motif; other site
485915004934	arginine finger; other site
485915004935	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
485915004936	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
485915004937	4Fe-4S binding domain; Region: Fer4; pfam00037
485915004938	Predicted amidohydrolase [General function prediction only]; Region: COG0388
485915004939	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
485915004940	active site
485915004941	catalytic triad [active]
485915004942	dimer interface [polypeptide binding]; other site
485915004943	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
485915004944	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
485915004945	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
485915004946	G1 box; other site
485915004947	putative GEF interaction site [polypeptide binding]; other site
485915004948	GTP/Mg2+ binding site [chemical binding]; other site
485915004949	Switch I region; other site
485915004950	G2 box; other site
485915004951	G3 box; other site
485915004952	Switch II region; other site
485915004953	G4 box; other site
485915004954	G5 box; other site
485915004955	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
485915004956	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
485915004957	AAA domain; Region: AAA_23; pfam13476
485915004958	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
485915004959	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
485915004960	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
485915004961	active site
485915004962	metal binding site [ion binding]; metal-binding site
485915004963	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
485915004964	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
485915004965	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
485915004966	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
485915004967	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
485915004968	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915004969	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915004970	metal binding site [ion binding]; metal-binding site
485915004971	active site
485915004972	I-site; other site
485915004973	mercuric reductase; Validated; Region: PRK06370
485915004974	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
485915004975	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
485915004976	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
485915004977	GxxExxY protein; Region: GxxExxY; TIGR04256
485915004978	transposase/IS protein; Provisional; Region: PRK09183
485915004979	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915004980	Walker A motif; other site
485915004981	ATP binding site [chemical binding]; other site
485915004982	Walker B motif; other site
485915004983	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
485915004984	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
485915004985	Integrase core domain; Region: rve; pfam00665
485915004986	Transposase; Region: DEDD_Tnp_IS110; pfam01548
485915004987	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
485915004988	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915004989	PAS domain; Region: PAS_9; pfam13426
485915004990	putative active site [active]
485915004991	heme pocket [chemical binding]; other site
485915004992	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915004993	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
485915004994	Walker A motif; other site
485915004995	ATP binding site [chemical binding]; other site
485915004996	Walker B motif; other site
485915004997	arginine finger; other site
485915004998	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915004999	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
485915005000	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
485915005001	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
485915005002	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
485915005003	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
485915005004	dimer interface [polypeptide binding]; other site
485915005005	putative CheW interface [polypeptide binding]; other site
485915005006	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
485915005007	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
485915005008	substrate binding pocket [chemical binding]; other site
485915005009	membrane-bound complex binding site; other site
485915005010	hinge residues; other site
485915005011	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
485915005012	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
485915005013	N-acetyl-D-glucosamine binding site [chemical binding]; other site
485915005014	catalytic residue [active]
485915005015	Protein of unknown function (DUF554); Region: DUF554; pfam04474
485915005016	Uncharacterized conserved protein [Function unknown]; Region: COG3339
485915005017	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915005018	PAS domain; Region: PAS_9; pfam13426
485915005019	putative active site [active]
485915005020	heme pocket [chemical binding]; other site
485915005021	GAF domain; Region: GAF; cl17456
485915005022	GAF domain; Region: GAF_2; pfam13185
485915005023	PAS fold; Region: PAS_4; pfam08448
485915005024	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915005025	putative active site [active]
485915005026	heme pocket [chemical binding]; other site
485915005027	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915005028	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915005029	metal binding site [ion binding]; metal-binding site
485915005030	active site
485915005031	I-site; other site
485915005032	Uncharacterized conserved protein [Function unknown]; Region: COG0397
485915005033	hypothetical protein; Validated; Region: PRK00029
485915005034	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
485915005035	S1 domain; Region: S1_2; pfam13509
485915005036	S1 domain; Region: S1_2; pfam13509
485915005037	PilZ domain; Region: PilZ; pfam07238
485915005038	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
485915005039	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
485915005040	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
485915005041	DXD motif; other site
485915005042	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915005043	binding surface
485915005044	TPR motif; other site
485915005045	TPR repeat; Region: TPR_11; pfam13414
485915005046	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915005047	binding surface
485915005048	TPR motif; other site
485915005049	TPR repeat; Region: TPR_11; pfam13414
485915005050	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915005051	TPR motif; other site
485915005052	Tetratricopeptide repeat; Region: TPR_16; pfam13432
485915005053	binding surface
485915005054	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
485915005055	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
485915005056	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
485915005057	anti sigma factor interaction site; other site
485915005058	regulatory phosphorylation site [posttranslational modification]; other site
485915005059	PAS domain S-box; Region: sensory_box; TIGR00229
485915005060	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915005061	putative active site [active]
485915005062	heme pocket [chemical binding]; other site
485915005063	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
485915005064	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
485915005065	TspO/MBR family; Region: TspO_MBR; pfam03073
485915005066	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915005067	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915005068	metal binding site [ion binding]; metal-binding site
485915005069	active site
485915005070	I-site; other site
485915005071	B12 binding domain; Region: B12-binding_2; pfam02607
485915005072	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
485915005073	B12 binding domain; Region: B12-binding; pfam02310
485915005074	B12 binding site [chemical binding]; other site
485915005075	Protein of unknown function (DUF3830); Region: DUF3830; pfam12903
485915005076	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
485915005077	probable regulatory domain; Region: near_KaiC_dom; TIGR03879
485915005078	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
485915005079	putative Mg++ binding site [ion binding]; other site
485915005080	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
485915005081	ATP-binding site [chemical binding]; other site
485915005082	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
485915005083	putative homodimer interface [polypeptide binding]; other site
485915005084	PLD-like domain; Region: PLDc_2; pfam13091
485915005085	putative active site [active]
485915005086	catalytic site [active]
485915005087	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
485915005088	Transposase; Region: DDE_Tnp_ISL3; pfam01610
485915005089	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532
485915005090	metal binding site [ion binding]; metal-binding site
485915005091	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b; cd09180
485915005092	PLD-like domain; Region: PLDc_2; pfam13091
485915005093	putative homodimer interface [polypeptide binding]; other site
485915005094	putative active site [active]
485915005095	catalytic site [active]
485915005096	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
485915005097	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
485915005098	ATP binding site [chemical binding]; other site
485915005099	putative Mg++ binding site [ion binding]; other site
485915005100	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
485915005101	nucleotide binding region [chemical binding]; other site
485915005102	ATP-binding site [chemical binding]; other site
485915005103	Methyltransferase domain; Region: Methyltransf_23; pfam13489
485915005104	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915005105	S-adenosylmethionine binding site [chemical binding]; other site
485915005106	HNH endonuclease; Region: HNH_2; pfam13391
485915005107	Preprotein translocase SecG subunit; Region: SecG; pfam03840
485915005108	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
485915005109	triosephosphate isomerase; Provisional; Region: PRK14565
485915005110	substrate binding site [chemical binding]; other site
485915005111	dimer interface [polypeptide binding]; other site
485915005112	catalytic triad [active]
485915005113	Phosphoglycerate kinase; Region: PGK; pfam00162
485915005114	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
485915005115	substrate binding site [chemical binding]; other site
485915005116	hinge regions; other site
485915005117	ADP binding site [chemical binding]; other site
485915005118	catalytic site [active]
485915005119	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
485915005120	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
485915005121	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
485915005122	nudix motif; other site
485915005123	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
485915005124	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
485915005125	active site
485915005126	dimerization interface [polypeptide binding]; other site
485915005127	rod shape-determining protein MreB; Provisional; Region: PRK13930
485915005128	MreB and similar proteins; Region: MreB_like; cd10225
485915005129	nucleotide binding site [chemical binding]; other site
485915005130	Mg binding site [ion binding]; other site
485915005131	putative protofilament interaction site [polypeptide binding]; other site
485915005132	RodZ interaction site [polypeptide binding]; other site
485915005133	GAF domain; Region: GAF; pfam01590
485915005134	GAF domain; Region: GAF_2; pfam13185
485915005135	GAF domain; Region: GAF; pfam01590
485915005136	GAF domain; Region: GAF_2; pfam13185
485915005137	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
485915005138	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
485915005139	Transposase; Region: DEDD_Tnp_IS110; pfam01548
485915005140	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
485915005141	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
485915005142	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
485915005143	RNA methyltransferase, RsmE family; Region: TIGR00046
485915005144	recombination factor protein RarA; Reviewed; Region: PRK13342
485915005145	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915005146	Walker A motif; other site
485915005147	ATP binding site [chemical binding]; other site
485915005148	Walker B motif; other site
485915005149	arginine finger; other site
485915005150	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
485915005151	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
485915005152	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
485915005153	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
485915005154	Peptidase M16C associated; Region: M16C_assoc; pfam08367
485915005155	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
485915005156	binding surface
485915005157	TPR motif; other site
485915005158	Tetratricopeptide repeat; Region: TPR_16; pfam13432
485915005159	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915005160	Tetratricopeptide repeat; Region: TPR_16; pfam13432
485915005161	TPR motif; other site
485915005162	binding surface
485915005163	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915005164	binding surface
485915005165	Tetratricopeptide repeat; Region: TPR_16; pfam13432
485915005166	TPR motif; other site
485915005167	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
485915005168	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
485915005169	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
485915005170	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
485915005171	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
485915005172	DNA binding residues [nucleotide binding]
485915005173	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
485915005174	active site
485915005175	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
485915005176	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
485915005177	NAD binding site [chemical binding]; other site
485915005178	homodimer interface [polypeptide binding]; other site
485915005179	active site
485915005180	substrate binding site [chemical binding]; other site
485915005181	Transposase; Region: DEDD_Tnp_IS110; pfam01548
485915005182	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
485915005183	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
485915005184	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
485915005185	lipoyl attachment site [posttranslational modification]; other site
485915005186	glycine dehydrogenase subunit 1; Validated; Region: PRK00451
485915005187	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
485915005188	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
485915005189	catalytic residue [active]
485915005190	glycine dehydrogenase subunit 2; Validated; Region: PRK04366
485915005191	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
485915005192	catalytic residue [active]
485915005193	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
485915005194	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
485915005195	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
485915005196	Maf-like protein; Region: Maf; pfam02545
485915005197	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
485915005198	active site
485915005199	dimer interface [polypeptide binding]; other site
485915005200	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
485915005201	tetramer interfaces [polypeptide binding]; other site
485915005202	binuclear metal-binding site [ion binding]; other site
485915005203	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
485915005204	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
485915005205	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
485915005206	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
485915005207	ligand binding site [chemical binding]; other site
485915005208	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
485915005209	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
485915005210	TonB C terminal; Region: TonB_2; pfam13103
485915005211	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
485915005212	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
485915005213	TolR protein; Region: tolR; TIGR02801
485915005214	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
485915005215	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
485915005216	active site
485915005217	hypothetical protein; Provisional; Region: PRK06361
485915005218	Bifunctional nuclease; Region: DNase-RNase; pfam02577
485915005219	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14337
485915005220	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
485915005221	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915005222	FeS/SAM binding site; other site
485915005223	TRAM domain; Region: TRAM; cl01282
485915005224	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
485915005225	AAA domain; Region: AAA_33; pfam13671
485915005226	active site
485915005227	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
485915005228	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
485915005229	active site
485915005230	trimerization site [polypeptide binding]; other site
485915005231	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
485915005232	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
485915005233	DHHA2 domain; Region: DHHA2; pfam02833
485915005234	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
485915005235	active site
485915005236	phosphorylation site [posttranslational modification]
485915005237	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
485915005238	active pocket/dimerization site; other site
485915005239	active site
485915005240	phosphorylation site [posttranslational modification]
485915005241	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
485915005242	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
485915005243	active site
485915005244	phosphorylation site [posttranslational modification]
485915005245	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
485915005246	30S subunit binding site; other site
485915005247	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
485915005248	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
485915005249	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
485915005250	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
485915005251	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
485915005252	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
485915005253	Walker A/P-loop; other site
485915005254	ATP binding site [chemical binding]; other site
485915005255	Q-loop/lid; other site
485915005256	ABC transporter signature motif; other site
485915005257	Walker B; other site
485915005258	D-loop; other site
485915005259	H-loop/switch region; other site
485915005260	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
485915005261	OstA-like protein; Region: OstA; pfam03968
485915005262	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
485915005263	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
485915005264	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
485915005265	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
485915005266	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
485915005267	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
485915005268	CTP synthetase; Validated; Region: pyrG; PRK05380
485915005269	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
485915005270	Catalytic site [active]
485915005271	active site
485915005272	UTP binding site [chemical binding]; other site
485915005273	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
485915005274	active site
485915005275	putative oxyanion hole; other site
485915005276	catalytic triad [active]
485915005277	CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507
485915005278	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
485915005279	putative active site [active]
485915005280	catalytic triad [active]
485915005281	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
485915005282	nucleoside/Zn binding site; other site
485915005283	dimer interface [polypeptide binding]; other site
485915005284	catalytic motif [active]
485915005285	integrase; Provisional; Region: PRK09692
485915005286	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
485915005287	active site
485915005288	Int/Topo IB signature motif; other site
485915005289	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
485915005290	generic binding surface I; other site
485915005291	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
485915005292	generic binding surface II; other site
485915005293	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
485915005294	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
485915005295	CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621
485915005296	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
485915005297	CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767
485915005298	CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767
485915005299	CRISPR-associated protein Csx17, subtype Dpsyc; Region: cas_csx17; TIGR04113
485915005300	CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834
485915005301	CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827
485915005302	Staphylococcal nuclease homologues; Region: SNc; smart00318
485915005303	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
485915005304	Catalytic site; other site
485915005305	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
485915005306	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
485915005307	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
485915005308	4Fe-4S binding domain; Region: Fer4; pfam00037
485915005309	Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143
485915005310	putative FMN binding site [chemical binding]; other site
485915005311	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
485915005312	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
485915005313	non-heme iron binding site [ion binding]; other site
485915005314	dimer interface [polypeptide binding]; other site
485915005315	Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679
485915005316	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
485915005317	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
485915005318	Cl- selectivity filter; other site
485915005319	Cl- binding residues [ion binding]; other site
485915005320	pore gating glutamate residue; other site
485915005321	dimer interface [polypeptide binding]; other site
485915005322	FOG: CBS domain [General function prediction only]; Region: COG0517
485915005323	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
485915005324	4Fe-4S binding domain; Region: Fer4_5; pfam12801
485915005325	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
485915005326	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915005327	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
485915005328	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
485915005329	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
485915005330	4Fe-4S binding domain; Region: Fer4; pfam00037
485915005331	Uncharacterized conserved protein [Function unknown]; Region: COG2006
485915005332	Domain of unknown function (DUF362); Region: DUF362; pfam04015
485915005333	conserved hypothetical protein; Region: TIGR02231
485915005334	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
485915005335	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
485915005336	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
485915005337	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
485915005338	ligand binding site [chemical binding]; other site
485915005339	flexible hinge region; other site
485915005340	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
485915005341	putative switch regulator; other site
485915005342	non-specific DNA interactions [nucleotide binding]; other site
485915005343	DNA binding site [nucleotide binding]
485915005344	sequence specific DNA binding site [nucleotide binding]; other site
485915005345	putative cAMP binding site [chemical binding]; other site
485915005346	Rubrerythrin [Energy production and conversion]; Region: COG1592
485915005347	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
485915005348	binuclear metal center [ion binding]; other site
485915005349	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
485915005350	iron binding site [ion binding]; other site
485915005351	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
485915005352	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
485915005353	Walker A/P-loop; other site
485915005354	ATP binding site [chemical binding]; other site
485915005355	Q-loop/lid; other site
485915005356	ABC transporter signature motif; other site
485915005357	Walker B; other site
485915005358	D-loop; other site
485915005359	H-loop/switch region; other site
485915005360	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
485915005361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915005362	dimer interface [polypeptide binding]; other site
485915005363	conserved gate region; other site
485915005364	putative PBP binding loops; other site
485915005365	ABC-ATPase subunit interface; other site
485915005366	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
485915005367	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
485915005368	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915005369	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
485915005370	putative active site [active]
485915005371	heme pocket [chemical binding]; other site
485915005372	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915005373	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
485915005374	putative active site [active]
485915005375	heme pocket [chemical binding]; other site
485915005376	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915005377	putative active site [active]
485915005378	heme pocket [chemical binding]; other site
485915005379	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
485915005380	GAF domain; Region: GAF; cl17456
485915005381	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915005382	dimer interface [polypeptide binding]; other site
485915005383	phosphorylation site [posttranslational modification]
485915005384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915005385	ATP binding site [chemical binding]; other site
485915005386	Mg2+ binding site [ion binding]; other site
485915005387	G-X-G motif; other site
485915005388	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915005389	active site
485915005390	phosphorylation site [posttranslational modification]
485915005391	intermolecular recognition site; other site
485915005392	dimerization interface [polypeptide binding]; other site
485915005393	Uncharacterized ArCR, COG2043; Region: DUF169; cl00894
485915005394	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
485915005395	putative hydrophobic ligand binding site [chemical binding]; other site
485915005396	TPR repeat; Region: TPR_11; pfam13414
485915005397	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915005398	TPR motif; other site
485915005399	binding surface
485915005400	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
485915005401	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
485915005402	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
485915005403	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
485915005404	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
485915005405	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
485915005406	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
485915005407	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
485915005408	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
485915005409	active site
485915005410	catalytic site [active]
485915005411	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
485915005412	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
485915005413	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
485915005414	Walker A motif; other site
485915005415	ATP binding site [chemical binding]; other site
485915005416	Walker B motif; other site
485915005417	ketol-acid reductoisomerase; Provisional; Region: PRK05479
485915005418	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
485915005419	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
485915005420	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
485915005421	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
485915005422	putative valine binding site [chemical binding]; other site
485915005423	dimer interface [polypeptide binding]; other site
485915005424	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
485915005425	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
485915005426	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
485915005427	PYR/PP interface [polypeptide binding]; other site
485915005428	dimer interface [polypeptide binding]; other site
485915005429	TPP binding site [chemical binding]; other site
485915005430	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
485915005431	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
485915005432	TPP-binding site [chemical binding]; other site
485915005433	dimer interface [polypeptide binding]; other site
485915005434	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
485915005435	YGGT family; Region: YGGT; pfam02325
485915005436	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
485915005437	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
485915005438	active site
485915005439	motif I; other site
485915005440	motif II; other site
485915005441	AMP-binding domain protein; Validated; Region: PRK08315
485915005442	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
485915005443	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
485915005444	acyl-activating enzyme (AAE) consensus motif; other site
485915005445	acyl-activating enzyme (AAE) consensus motif; other site
485915005446	putative AMP binding site [chemical binding]; other site
485915005447	putative active site [active]
485915005448	putative CoA binding site [chemical binding]; other site
485915005449	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
485915005450	non-specific DNA binding site [nucleotide binding]; other site
485915005451	salt bridge; other site
485915005452	sequence-specific DNA binding site [nucleotide binding]; other site
485915005453	Cupin domain; Region: Cupin_2; pfam07883
485915005454	twin arginine translocase protein A; Provisional; Region: tatA; PRK14859
485915005455	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
485915005456	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
485915005457	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
485915005458	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
485915005459	active site
485915005460	(T/H)XGH motif; other site
485915005461	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
485915005462	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915005463	S-adenosylmethionine binding site [chemical binding]; other site
485915005464	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
485915005465	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
485915005466	Beta-Casp domain; Region: Beta-Casp; smart01027
485915005467	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
485915005468	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
485915005469	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
485915005470	metal binding site [ion binding]; metal-binding site
485915005471	nucleotidyl binding site; other site
485915005472	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
485915005473	Smr domain; Region: Smr; pfam01713
485915005474	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
485915005475	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
485915005476	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
485915005477	P loop; other site
485915005478	GTP binding site [chemical binding]; other site
485915005479	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
485915005480	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
485915005481	active site
485915005482	Domain of unknown function (DUF814); Region: DUF814; pfam05670
485915005483	adenylate kinase; Provisional; Region: PRK14529
485915005484	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
485915005485	AMP-binding site [chemical binding]; other site
485915005486	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
485915005487	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
485915005488	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
485915005489	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
485915005490	DALR anticodon binding domain; Region: DALR_1; pfam05746
485915005491	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
485915005492	motif 1; other site
485915005493	dimer interface [polypeptide binding]; other site
485915005494	active site
485915005495	motif 2; other site
485915005496	motif 3; other site
485915005497	Recombination protein O N terminal; Region: RecO_N; pfam11967
485915005498	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
485915005499	Recombination protein O C terminal; Region: RecO_C; pfam02565
485915005500	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
485915005501	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
485915005502	non-specific DNA binding site [nucleotide binding]; other site
485915005503	salt bridge; other site
485915005504	sequence-specific DNA binding site [nucleotide binding]; other site
485915005505	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
485915005506	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
485915005507	SurA N-terminal domain; Region: SurA_N_3; cl07813
485915005508	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
485915005509	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
485915005510	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
485915005511	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
485915005512	ATP binding site [chemical binding]; other site
485915005513	putative Mg++ binding site [ion binding]; other site
485915005514	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
485915005515	nucleotide binding region [chemical binding]; other site
485915005516	ATP-binding site [chemical binding]; other site
485915005517	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
485915005518	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
485915005519	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
485915005520	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
485915005521	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
485915005522	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
485915005523	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
485915005524	Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967
485915005525	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
485915005526	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
485915005527	active site
485915005528	hydrophilic channel; other site
485915005529	dimerization interface [polypeptide binding]; other site
485915005530	catalytic residues [active]
485915005531	active site lid [active]
485915005532	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14657
485915005533	putative carbohydrate kinase; Provisional; Region: PRK10565
485915005534	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
485915005535	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
485915005536	putative substrate binding site [chemical binding]; other site
485915005537	putative ATP binding site [chemical binding]; other site
485915005538	FOG: CBS domain [General function prediction only]; Region: COG0517
485915005539	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
485915005540	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
485915005541	aspartate kinase; Reviewed; Region: PRK06635
485915005542	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
485915005543	putative nucleotide binding site [chemical binding]; other site
485915005544	putative catalytic residues [active]
485915005545	putative Mg ion binding site [ion binding]; other site
485915005546	putative aspartate binding site [chemical binding]; other site
485915005547	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
485915005548	putative allosteric regulatory site; other site
485915005549	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
485915005550	putative allosteric regulatory residue; other site
485915005551	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
485915005552	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
485915005553	active site
485915005554	catalytic residues [active]
485915005555	metal binding site [ion binding]; metal-binding site
485915005556	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
485915005557	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
485915005558	Esterase/lipase [General function prediction only]; Region: COG1647
485915005559	Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219
485915005560	Catalytic domain of Protein Kinases; Region: PKc; cd00180
485915005561	active site
485915005562	ATP binding site [chemical binding]; other site
485915005563	substrate binding site [chemical binding]; other site
485915005564	activation loop (A-loop); other site
485915005565	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
485915005566	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
485915005567	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
485915005568	active site
485915005569	metal binding site [ion binding]; metal-binding site
485915005570	CrcB-like protein; Region: CRCB; cl09114
485915005571	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
485915005572	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
485915005573	Catalytic site [active]
485915005574	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
485915005575	intracellular protease, PfpI family; Region: PfpI; TIGR01382
485915005576	proposed catalytic triad [active]
485915005577	conserved cys residue [active]
485915005578	ParB-like nuclease domain; Region: ParBc; pfam02195
485915005579	Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582
485915005580	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
485915005581	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
485915005582	putative dimer interface [polypeptide binding]; other site
485915005583	putative anticodon binding site; other site
485915005584	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
485915005585	homodimer interface [polypeptide binding]; other site
485915005586	motif 1; other site
485915005587	motif 2; other site
485915005588	active site
485915005589	motif 3; other site
485915005590	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
485915005591	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
485915005592	ATP binding site [chemical binding]; other site
485915005593	putative Mg++ binding site [ion binding]; other site
485915005594	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
485915005595	ATP-binding site [chemical binding]; other site
485915005596	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
485915005597	active site
485915005598	tetramer interface; other site
485915005599	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
485915005600	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
485915005601	active site
485915005602	substrate binding site [chemical binding]; other site
485915005603	metal binding site [ion binding]; metal-binding site
485915005604	YbbR-like protein; Region: YbbR; pfam07949
485915005605	YbbR-like protein; Region: YbbR; pfam07949
485915005606	Uncharacterized conserved protein [Function unknown]; Region: COG1624
485915005607	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
485915005608	dihydropteroate synthase; Region: DHPS; TIGR01496
485915005609	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
485915005610	substrate binding pocket [chemical binding]; other site
485915005611	dimer interface [polypeptide binding]; other site
485915005612	inhibitor binding site; inhibition site
485915005613	FtsH Extracellular; Region: FtsH_ext; pfam06480
485915005614	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
485915005615	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915005616	Walker A motif; other site
485915005617	ATP binding site [chemical binding]; other site
485915005618	Walker B motif; other site
485915005619	arginine finger; other site
485915005620	Peptidase family M41; Region: Peptidase_M41; pfam01434
485915005621	argininosuccinate lyase; Provisional; Region: PRK00855
485915005622	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
485915005623	active sites [active]
485915005624	tetramer interface [polypeptide binding]; other site
485915005625	argininosuccinate synthase; Provisional; Region: PRK13820
485915005626	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
485915005627	ANP binding site [chemical binding]; other site
485915005628	Substrate Binding Site II [chemical binding]; other site
485915005629	Substrate Binding Site I [chemical binding]; other site
485915005630	ornithine carbamoyltransferase; Provisional; Region: PRK00779
485915005631	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
485915005632	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
485915005633	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
485915005634	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
485915005635	PhoH-like protein; Region: PhoH; pfam02562
485915005636	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
485915005637	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915005638	FeS/SAM binding site; other site
485915005639	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
485915005640	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
485915005641	Domain of unknown function (DUF814); Region: DUF814; pfam05670
485915005642	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
485915005643	Putative methyltransferase; Region: Methyltransf_16; pfam10294
485915005644	putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266
485915005645	YcaO-like family; Region: YcaO; pfam02624
485915005646	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915005647	binding surface
485915005648	TPR motif; other site
485915005649	TPR repeat; Region: TPR_11; pfam13414
485915005650	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
485915005651	DsrC like protein; Region: DsrC; pfam04358
485915005652	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399
485915005653	MoaD interaction [polypeptide binding]; other site
485915005654	active site residues [active]
485915005655	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
485915005656	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
485915005657	active site
485915005658	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
485915005659	hypothetical protein; Provisional; Region: PRK04334
485915005660	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
485915005661	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
485915005662	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915005663	Walker A motif; other site
485915005664	ATP binding site [chemical binding]; other site
485915005665	Walker B motif; other site
485915005666	arginine finger; other site
485915005667	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
485915005668	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14602
485915005669	RuvA N terminal domain; Region: RuvA_N; pfam01330
485915005670	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
485915005671	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
485915005672	active site
485915005673	putative DNA-binding cleft [nucleotide binding]; other site
485915005674	dimer interface [polypeptide binding]; other site
485915005675	hypothetical protein; Validated; Region: PRK00110
485915005676	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
485915005677	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915005678	S-adenosylmethionine binding site [chemical binding]; other site
485915005679	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
485915005680	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
485915005681	TPP-binding site [chemical binding]; other site
485915005682	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
485915005683	PYR/PP interface [polypeptide binding]; other site
485915005684	Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916
485915005685	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
485915005686	DEAD-like helicases superfamily; Region: DEXDc; smart00487
485915005687	ATP binding site [chemical binding]; other site
485915005688	Mg++ binding site [ion binding]; other site
485915005689	motif III; other site
485915005690	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
485915005691	nucleotide binding region [chemical binding]; other site
485915005692	ATP-binding site [chemical binding]; other site
485915005693	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
485915005694	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
485915005695	TRAM domain; Region: TRAM; cl01282
485915005696	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
485915005697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915005698	S-adenosylmethionine binding site [chemical binding]; other site
485915005699	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
485915005700	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
485915005701	acyl-activating enzyme (AAE) consensus motif; other site
485915005702	putative AMP binding site [chemical binding]; other site
485915005703	putative active site [active]
485915005704	putative CoA binding site [chemical binding]; other site
485915005705	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
485915005706	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
485915005707	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
485915005708	TPP-binding site; other site
485915005709	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
485915005710	PYR/PP interface [polypeptide binding]; other site
485915005711	dimer interface [polypeptide binding]; other site
485915005712	TPP binding site [chemical binding]; other site
485915005713	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
485915005714	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
485915005715	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
485915005716	substrate binding pocket [chemical binding]; other site
485915005717	chain length determination region; other site
485915005718	substrate-Mg2+ binding site; other site
485915005719	catalytic residues [active]
485915005720	aspartate-rich region 1; other site
485915005721	active site lid residues [active]
485915005722	aspartate-rich region 2; other site
485915005723	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
485915005724	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
485915005725	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
485915005726	generic binding surface II; other site
485915005727	generic binding surface I; other site
485915005728	prolyl-tRNA synthetase; Provisional; Region: PRK09194
485915005729	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
485915005730	dimer interface [polypeptide binding]; other site
485915005731	motif 1; other site
485915005732	active site
485915005733	motif 2; other site
485915005734	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
485915005735	putative deacylase active site [active]
485915005736	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
485915005737	active site
485915005738	motif 3; other site
485915005739	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
485915005740	anticodon binding site; other site
485915005741	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
485915005742	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
485915005743	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
485915005744	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
485915005745	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
485915005746	Active Sites [active]
485915005747	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
485915005748	Na2 binding site [ion binding]; other site
485915005749	putative substrate binding site 1 [chemical binding]; other site
485915005750	Na binding site 1 [ion binding]; other site
485915005751	putative substrate binding site 2 [chemical binding]; other site
485915005752	Chorismate mutase type II; Region: CM_2; cl00693
485915005753	PAS domain; Region: PAS; smart00091
485915005754	PAS domain S-box; Region: sensory_box; TIGR00229
485915005755	putative active site [active]
485915005756	heme pocket [chemical binding]; other site
485915005757	PAS domain; Region: PAS; smart00091
485915005758	PAS domain; Region: PAS_9; pfam13426
485915005759	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
485915005760	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915005761	dimer interface [polypeptide binding]; other site
485915005762	phosphorylation site [posttranslational modification]
485915005763	aconitate hydratase; Validated; Region: PRK07229
485915005764	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
485915005765	substrate binding site [chemical binding]; other site
485915005766	ligand binding site [chemical binding]; other site
485915005767	Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle.  Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579
485915005768	substrate binding site [chemical binding]; other site
485915005769	periplasmic folding chaperone; Provisional; Region: PRK10788
485915005770	SurA N-terminal domain; Region: SurA_N_3; cl07813
485915005771	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
485915005772	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
485915005773	DNA polymerase IV; Provisional; Region: PRK14133
485915005774	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
485915005775	active site
485915005776	DNA binding site [nucleotide binding]
485915005777	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
485915005778	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
485915005779	HipA N-terminal domain; Region: Couple_hipA; pfam13657
485915005780	HipA-like N-terminal domain; Region: HipA_N; pfam07805
485915005781	HipA-like C-terminal domain; Region: HipA_C; pfam07804
485915005782	transcriptional regulator, y4mF family; Region: couple_hipB; TIGR03070
485915005783	non-specific DNA binding site [nucleotide binding]; other site
485915005784	salt bridge; other site
485915005785	sequence-specific DNA binding site [nucleotide binding]; other site
485915005786	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
485915005787	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
485915005788	GIY-YIG motif/motif A; other site
485915005789	active site
485915005790	catalytic site [active]
485915005791	putative DNA binding site [nucleotide binding]; other site
485915005792	metal binding site [ion binding]; metal-binding site
485915005793	UvrB/uvrC motif; Region: UVR; pfam02151
485915005794	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
485915005795	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
485915005796	Peptidase family M23; Region: Peptidase_M23; pfam01551
485915005797	Peptidase family M48; Region: Peptidase_M48; cl12018
485915005798	TPR repeat; Region: TPR_11; pfam13414
485915005799	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915005800	binding surface
485915005801	TPR motif; other site
485915005802	Low molecular weight phosphatase family; Region: LMWPc; cd00115
485915005803	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
485915005804	active site
485915005805	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
485915005806	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
485915005807	Predicted permeases [General function prediction only]; Region: COG0701
485915005808	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
485915005809	dimerization interface [polypeptide binding]; other site
485915005810	putative DNA binding site [nucleotide binding]; other site
485915005811	putative Zn2+ binding site [ion binding]; other site
485915005812	4Fe-4S binding domain; Region: Fer4_5; pfam12801
485915005813	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
485915005814	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
485915005815	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
485915005816	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
485915005817	catalytic residues [active]
485915005818	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182
485915005819	Radical SAM superfamily; Region: Radical_SAM; pfam04055
485915005820	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
485915005821	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
485915005822	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
485915005823	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
485915005824	nucleophile elbow; other site
485915005825	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
485915005826	TrkA-N domain; Region: TrkA_N; pfam02254
485915005827	TrkA-C domain; Region: TrkA_C; pfam02080
485915005828	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
485915005829	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
485915005830	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
485915005831	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
485915005832	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
485915005833	TrkA-N domain; Region: TrkA_N; pfam02254
485915005834	TrkA-C domain; Region: TrkA_C; pfam02080
485915005835	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
485915005836	Ligand Binding Site [chemical binding]; other site
485915005837	PAS fold; Region: PAS_4; pfam08448
485915005838	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915005839	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915005840	metal binding site [ion binding]; metal-binding site
485915005841	active site
485915005842	I-site; other site
485915005843	Predicted membrane protein [Function unknown]; Region: COG1971
485915005844	Domain of unknown function DUF; Region: DUF204; pfam02659
485915005845	Domain of unknown function DUF; Region: DUF204; pfam02659
485915005846	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
485915005847	heme-binding residues [chemical binding]; other site
485915005848	TPR repeat; Region: TPR_11; pfam13414
485915005849	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915005850	binding surface
485915005851	TPR motif; other site
485915005852	TPR repeat; Region: TPR_11; pfam13414
485915005853	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
485915005854	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
485915005855	Short C-terminal domain; Region: SHOCT; pfam09851
485915005856	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
485915005857	dimer interface [polypeptide binding]; other site
485915005858	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
485915005859	putative MPT binding site; other site
485915005860	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
485915005861	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
485915005862	catalytic loop [active]
485915005863	iron binding site [ion binding]; other site
485915005864	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
485915005865	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
485915005866	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
485915005867	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
485915005868	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
485915005869	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
485915005870	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915005871	S-adenosylmethionine binding site [chemical binding]; other site
485915005872	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
485915005873	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964
485915005874	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915005875	FeS/SAM binding site; other site
485915005876	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
485915005877	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
485915005878	acyl-activating enzyme (AAE) consensus motif; other site
485915005879	active site
485915005880	AMP binding site [chemical binding]; other site
485915005881	CoA binding site [chemical binding]; other site
485915005882	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
485915005883	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
485915005884	XdhC Rossmann domain; Region: XdhC_C; pfam13478
485915005885	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
485915005886	Ligand binding site; other site
485915005887	metal-binding site
485915005888	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
485915005889	Zn2+ binding site [ion binding]; other site
485915005890	Mg2+ binding site [ion binding]; other site
485915005891	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
485915005892	catalytic core [active]
485915005893	Uncharacterized conserved protein [Function unknown]; Region: COG2014
485915005894	Domain of unknown function (DUF364); Region: DUF364; pfam04016
485915005895	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
485915005896	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915005897	Walker A/P-loop; other site
485915005898	ATP binding site [chemical binding]; other site
485915005899	Q-loop/lid; other site
485915005900	ABC transporter signature motif; other site
485915005901	Walker B; other site
485915005902	D-loop; other site
485915005903	H-loop/switch region; other site
485915005904	TOBE domain; Region: TOBE; cl01440
485915005905	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
485915005906	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915005907	dimer interface [polypeptide binding]; other site
485915005908	conserved gate region; other site
485915005909	putative PBP binding loops; other site
485915005910	ABC-ATPase subunit interface; other site
485915005911	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
485915005912	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
485915005913	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
485915005914	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
485915005915	V-type ATP synthase subunit E; Provisional; Region: PRK01558
485915005916	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
485915005917	Protein of unknown function (DUF2764); Region: DUF2764; pfam10962
485915005918	V-type ATP synthase subunit A; Provisional; Region: PRK04192
485915005919	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
485915005920	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
485915005921	Walker A motif/ATP binding site; other site
485915005922	Walker B motif; other site
485915005923	V-type ATP synthase subunit B; Provisional; Region: PRK02118
485915005924	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
485915005925	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
485915005926	Walker A motif homologous position; other site
485915005927	Walker B motif; other site
485915005928	V-type ATP synthase subunit D; Provisional; Region: PRK02195
485915005929	V-type ATP synthase subunit I; Validated; Region: PRK05771
485915005930	V-type ATP synthase subunit K; Validated; Region: PRK06649
485915005931	Sulphur transport; Region: Sulf_transp; pfam04143
485915005932	putative inner membrane protein; Provisional; Region: PRK11099
485915005933	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
485915005934	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
485915005935	active site residue [active]
485915005936	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
485915005937	active site residue [active]
485915005938	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
485915005939	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915005940	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915005941	metal binding site [ion binding]; metal-binding site
485915005942	active site
485915005943	I-site; other site
485915005944	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
485915005945	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
485915005946	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
485915005947	homodimer interaction site [polypeptide binding]; other site
485915005948	cofactor binding site; other site
485915005949	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
485915005950	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
485915005951	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
485915005952	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
485915005953	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
485915005954	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
485915005955	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
485915005956	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915005957	S-adenosylmethionine binding site [chemical binding]; other site
485915005958	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
485915005959	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
485915005960	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
485915005961	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
485915005962	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
485915005963	Na binding site [ion binding]; other site
485915005964	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
485915005965	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915005966	active site
485915005967	phosphorylation site [posttranslational modification]
485915005968	intermolecular recognition site; other site
485915005969	dimerization interface [polypeptide binding]; other site
485915005970	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
485915005971	DNA binding site [nucleotide binding]
485915005972	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
485915005973	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915005974	dimer interface [polypeptide binding]; other site
485915005975	phosphorylation site [posttranslational modification]
485915005976	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915005977	ATP binding site [chemical binding]; other site
485915005978	Mg2+ binding site [ion binding]; other site
485915005979	G-X-G motif; other site
485915005980	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
485915005981	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
485915005982	FMN binding site [chemical binding]; other site
485915005983	substrate binding site [chemical binding]; other site
485915005984	putative catalytic residue [active]
485915005985	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
485915005986	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
485915005987	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
485915005988	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
485915005989	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
485915005990	TrkA-N domain; Region: TrkA_N; pfam02254
485915005991	TrkA-C domain; Region: TrkA_C; pfam02080
485915005992	PAS domain; Region: PAS_9; pfam13426
485915005993	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
485915005994	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
485915005995	HSP70 interaction site [polypeptide binding]; other site
485915005996	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
485915005997	substrate binding site [polypeptide binding]; other site
485915005998	dimer interface [polypeptide binding]; other site
485915005999	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
485915006000	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
485915006001	Clp amino terminal domain; Region: Clp_N; pfam02861
485915006002	Clp amino terminal domain; Region: Clp_N; pfam02861
485915006003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915006004	Walker A motif; other site
485915006005	ATP binding site [chemical binding]; other site
485915006006	Walker B motif; other site
485915006007	arginine finger; other site
485915006008	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915006009	Walker A motif; other site
485915006010	ATP binding site [chemical binding]; other site
485915006011	Walker B motif; other site
485915006012	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
485915006013	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
485915006014	HSP70 interaction site [polypeptide binding]; other site
485915006015	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
485915006016	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
485915006017	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
485915006018	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
485915006019	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
485915006020	diaminopimelate aminotransferase; Provisional; Region: PRK13983
485915006021	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650
485915006022	metal binding site [ion binding]; metal-binding site
485915006023	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
485915006024	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
485915006025	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
485915006026	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
485915006027	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
485915006028	Transporter associated domain; Region: CorC_HlyC; smart01091
485915006029	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
485915006030	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
485915006031	putative active site [active]
485915006032	catalytic triad [active]
485915006033	putative dimer interface [polypeptide binding]; other site
485915006034	peptide chain release factor 2; Validated; Region: prfB; PRK00578
485915006035	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
485915006036	This domain is found in peptide chain release factors; Region: PCRF; smart00937
485915006037	RF-1 domain; Region: RF-1; pfam00472
485915006038	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
485915006039	IHF - DNA interface [nucleotide binding]; other site
485915006040	IHF dimer interface [polypeptide binding]; other site
485915006041	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
485915006042	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
485915006043	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
485915006044	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
485915006045	dihydrodipicolinate synthase; Region: dapA; TIGR00674
485915006046	dimer interface [polypeptide binding]; other site
485915006047	active site
485915006048	catalytic residue [active]
485915006049	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
485915006050	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
485915006051	active site
485915006052	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
485915006053	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
485915006054	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
485915006055	metal-binding site [ion binding]
485915006056	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
485915006057	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
485915006058	metal-binding site [ion binding]
485915006059	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
485915006060	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
485915006061	motif II; other site
485915006062	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
485915006063	Fic family protein [Function unknown]; Region: COG3177
485915006064	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
485915006065	Fic/DOC family; Region: Fic; pfam02661
485915006066	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
485915006067	dimerization interface [polypeptide binding]; other site
485915006068	putative Zn2+ binding site [ion binding]; other site
485915006069	putative DNA binding site [nucleotide binding]; other site
485915006070	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
485915006071	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
485915006072	Family description; Region: VCBS; pfam13517
485915006073	YtkA-like; Region: YtkA; pfam13115
485915006074	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
485915006075	Cell division protein FtsQ; Region: FtsQ; pfam03799
485915006076	Protein of unknown function (DUF3620); Region: DUF3620; cl02233
485915006077	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
485915006078	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
485915006079	metal binding triad [ion binding]; metal-binding site
485915006080	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
485915006081	Staphylococcal nuclease homologues; Region: SNc; smart00318
485915006082	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
485915006083	Catalytic site; other site
485915006084	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
485915006085	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
485915006086	non-specific DNA binding site [nucleotide binding]; other site
485915006087	salt bridge; other site
485915006088	sequence-specific DNA binding site [nucleotide binding]; other site
485915006089	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
485915006090	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
485915006091	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
485915006092	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
485915006093	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
485915006094	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
485915006095	DNA binding residues [nucleotide binding]
485915006096	DNA primase; Validated; Region: dnaG; PRK05667
485915006097	CHC2 zinc finger; Region: zf-CHC2; pfam01807
485915006098	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
485915006099	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
485915006100	active site
485915006101	metal binding site [ion binding]; metal-binding site
485915006102	interdomain interaction site; other site
485915006103	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
485915006104	MutS domain III; Region: MutS_III; cl17822
485915006105	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915006106	Walker A/P-loop; other site
485915006107	ATP binding site [chemical binding]; other site
485915006108	Q-loop/lid; other site
485915006109	ABC transporter signature motif; other site
485915006110	Walker B; other site
485915006111	D-loop; other site
485915006112	H-loop/switch region; other site
485915006113	Preprotein translocase subunit; Region: YajC; cl00806
485915006114	Smr domain; Region: Smr; pfam01713
485915006115	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
485915006116	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
485915006117	IHF dimer interface [polypeptide binding]; other site
485915006118	IHF - DNA interface [nucleotide binding]; other site
485915006119	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
485915006120	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
485915006121	S-adenosylmethionine binding site [chemical binding]; other site
485915006122	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
485915006123	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
485915006124	active site
485915006125	homotetramer interface [polypeptide binding]; other site
485915006126	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
485915006127	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
485915006128	active site
485915006129	motif I; other site
485915006130	motif II; other site
485915006131	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
485915006132	elongation factor G; Reviewed; Region: PRK12740
485915006133	G1 box; other site
485915006134	putative GEF interaction site [polypeptide binding]; other site
485915006135	GTP/Mg2+ binding site [chemical binding]; other site
485915006136	Switch I region; other site
485915006137	G2 box; other site
485915006138	G3 box; other site
485915006139	Switch II region; other site
485915006140	G4 box; other site
485915006141	G5 box; other site
485915006142	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
485915006143	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680
485915006144	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
485915006145	Outer membrane lipoprotein; Region: YfiO; pfam13525
485915006146	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915006147	binding surface
485915006148	TPR motif; other site
485915006149	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
485915006150	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
485915006151	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
485915006152	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
485915006153	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
485915006154	catalytic residues [active]
485915006155	UGMP family protein; Validated; Region: PRK09604
485915006156	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
485915006157	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
485915006158	AMP binding site [chemical binding]; other site
485915006159	metal binding site [ion binding]; metal-binding site
485915006160	active site
485915006161	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915006162	TPR motif; other site
485915006163	binding surface
485915006164	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
485915006165	Septum formation initiator; Region: DivIC; pfam04977
485915006166	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
485915006167	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
485915006168	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
485915006169	ATP binding site [chemical binding]; other site
485915006170	Walker B motif; other site
485915006171	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
485915006172	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
485915006173	Walker A motif; other site
485915006174	ATP binding site [chemical binding]; other site
485915006175	Walker B motif; other site
485915006176	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
485915006177	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
485915006178	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
485915006179	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
485915006180	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
485915006181	N-acetyl-D-glucosamine binding site [chemical binding]; other site
485915006182	catalytic residue [active]
485915006183	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
485915006184	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
485915006185	Walker A motif; other site
485915006186	Domain of unknown function (DUF368); Region: DUF368; pfam04018
485915006187	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
485915006188	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915006189	S-adenosylmethionine binding site [chemical binding]; other site
485915006190	FOG: CBS domain [General function prediction only]; Region: COG0517
485915006191	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
485915006192	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
485915006193	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
485915006194	nickel binding site [ion binding]; other site
485915006195	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
485915006196	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915006197	Walker A/P-loop; other site
485915006198	ATP binding site [chemical binding]; other site
485915006199	Q-loop/lid; other site
485915006200	ABC transporter signature motif; other site
485915006201	Walker B; other site
485915006202	D-loop; other site
485915006203	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
485915006204	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915006205	Walker A/P-loop; other site
485915006206	ATP binding site [chemical binding]; other site
485915006207	Q-loop/lid; other site
485915006208	ABC transporter signature motif; other site
485915006209	Walker B; other site
485915006210	D-loop; other site
485915006211	H-loop/switch region; other site
485915006212	aminotransferase; Validated; Region: PRK08175
485915006213	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
485915006214	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915006215	homodimer interface [polypeptide binding]; other site
485915006216	catalytic residue [active]
485915006217	homoserine dehydrogenase; Provisional; Region: PRK06349
485915006218	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
485915006219	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
485915006220	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
485915006221	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
485915006222	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
485915006223	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
485915006224	active site
485915006225	Amidohydrolase; Region: Amidohydro_2; pfam04909
485915006226	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
485915006227	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
485915006228	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
485915006229	ParB-like nuclease domain; Region: ParBc; cl02129
485915006230	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
485915006231	elongation factor G; Reviewed; Region: PRK12740
485915006232	G1 box; other site
485915006233	putative GEF interaction site [polypeptide binding]; other site
485915006234	GTP/Mg2+ binding site [chemical binding]; other site
485915006235	Switch I region; other site
485915006236	G2 box; other site
485915006237	G3 box; other site
485915006238	Switch II region; other site
485915006239	G4 box; other site
485915006240	G5 box; other site
485915006241	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
485915006242	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
485915006243	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
485915006244	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
485915006245	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
485915006246	putative acyl-acceptor binding pocket; other site
485915006247	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
485915006248	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
485915006249	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
485915006250	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
485915006251	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
485915006252	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
485915006253	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
485915006254	rRNA interaction site [nucleotide binding]; other site
485915006255	S8 interaction site; other site
485915006256	putative laminin-1 binding site; other site
485915006257	elongation factor Ts; Provisional; Region: tsf; PRK09377
485915006258	UBA/TS-N domain; Region: UBA; pfam00627
485915006259	Elongation factor TS; Region: EF_TS; pfam00889
485915006260	Elongation factor TS; Region: EF_TS; pfam00889
485915006261	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
485915006262	putative nucleotide binding site [chemical binding]; other site
485915006263	uridine monophosphate binding site [chemical binding]; other site
485915006264	homohexameric interface [polypeptide binding]; other site
485915006265	ribosome recycling factor; Reviewed; Region: frr; PRK00083
485915006266	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
485915006267	hinge region; other site
485915006268	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
485915006269	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
485915006270	catalytic residue [active]
485915006271	putative FPP diphosphate  binding site; other site
485915006272	putative FPP binding hydrophobic cleft; other site
485915006273	dimer interface [polypeptide binding]; other site
485915006274	putative IPP diphosphate binding site; other site
485915006275	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
485915006276	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
485915006277	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
485915006278	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
485915006279	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
485915006280	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
485915006281	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
485915006282	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
485915006283	active site
485915006284	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
485915006285	protein binding site [polypeptide binding]; other site
485915006286	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
485915006287	putative substrate binding region [chemical binding]; other site
485915006288	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
485915006289	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
485915006290	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
485915006291	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
485915006292	zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717
485915006293	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG2881
485915006294	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
485915006295	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915006296	FeS/SAM binding site; other site
485915006297	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
485915006298	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
485915006299	dimer interface [polypeptide binding]; other site
485915006300	active site
485915006301	Schiff base residues; other site
485915006302	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
485915006303	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915006304	FeS/SAM binding site; other site
485915006305	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
485915006306	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
485915006307	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
485915006308	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
485915006309	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
485915006310	substrate binding site [chemical binding]; other site
485915006311	hexamer interface [polypeptide binding]; other site
485915006312	metal binding site [ion binding]; metal-binding site
485915006313	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
485915006314	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
485915006315	putative DNA binding site [nucleotide binding]; other site
485915006316	putative Zn2+ binding site [ion binding]; other site
485915006317	AsnC family; Region: AsnC_trans_reg; pfam01037
485915006318	Proline dehydrogenase; Region: Pro_dh; cl03282
485915006319	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
485915006320	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
485915006321	Glutamate binding site [chemical binding]; other site
485915006322	homodimer interface [polypeptide binding]; other site
485915006323	NAD binding site [chemical binding]; other site
485915006324	catalytic residues [active]
485915006325	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
485915006326	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
485915006327	Na binding site [ion binding]; other site
485915006328	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915006329	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
485915006330	tricarballylate utilization protein B; Provisional; Region: PRK15033
485915006331	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
485915006332	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
485915006333	4Fe-4S binding domain; Region: Fer4; pfam00037
485915006334	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
485915006335	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
485915006336	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
485915006337	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
485915006338	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
485915006339	adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060
485915006340	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
485915006341	Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139
485915006342	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
485915006343	ATP-sulfurylase; Region: ATPS; cd00517
485915006344	active site
485915006345	HXXH motif; other site
485915006346	flexible loop; other site
485915006347	Cation transport protein; Region: TrkH; cl17365
485915006348	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
485915006349	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
485915006350	TrkA-N domain; Region: TrkA_N; pfam02254
485915006351	TrkA-C domain; Region: TrkA_C; pfam02080
485915006352	TrkA-N domain; Region: TrkA_N; pfam02254
485915006353	TrkA-C domain; Region: TrkA_C; pfam02080
485915006354	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
485915006355	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
485915006356	NAD binding site [chemical binding]; other site
485915006357	homotetramer interface [polypeptide binding]; other site
485915006358	homodimer interface [polypeptide binding]; other site
485915006359	substrate binding site [chemical binding]; other site
485915006360	active site
485915006361	Uncharacterized conserved protein [Function unknown]; Region: COG3937
485915006362	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
485915006363	ABC1 family; Region: ABC1; cl17513
485915006364	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
485915006365	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
485915006366	Part of AAA domain; Region: AAA_19; pfam13245
485915006367	Family description; Region: UvrD_C_2; pfam13538
485915006368	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
485915006369	probable DNA repair protein; Region: TIGR03623
485915006370	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
485915006371	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
485915006372	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
485915006373	Protein of unknown function (DUF401); Region: DUF401; cl00830
485915006374	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
485915006375	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
485915006376	nudix motif; other site
485915006377	amphi-Trp domain; Region: amphi-Trp; TIGR04354
485915006378	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
485915006379	PhoU domain; Region: PhoU; pfam01895
485915006380	PhoU domain; Region: PhoU; pfam01895
485915006381	Phosphotransferase enzyme family; Region: APH; pfam01636
485915006382	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
485915006383	active site
485915006384	ATP binding site [chemical binding]; other site
485915006385	Ecdysteroid kinase; Region: EcKinase; cl17738
485915006386	ATP-grasp enzyme, GAK system; Region: grasp_GAK; TIGR04356
485915006387	ATP-grasp domain; Region: ATP-grasp_4; cl17255
485915006388	HprK-related kinase B; Region: HprK_rel_B; TIGR04355
485915006389	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
485915006390	active site
485915006391	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
485915006392	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
485915006393	phosphate binding site [ion binding]; other site
485915006394	putative substrate binding pocket [chemical binding]; other site
485915006395	dimer interface [polypeptide binding]; other site
485915006396	amphi-Trp domain; Region: amphi-Trp; TIGR04354
485915006397	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
485915006398	PHP domain; Region: PHP; pfam02811
485915006399	active site
485915006400	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
485915006401	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
485915006402	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
485915006403	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
485915006404	type IV pilus assembly protein PilM; Region: pilM; TIGR01175
485915006405	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
485915006406	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
485915006407	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
485915006408	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
485915006409	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
485915006410	Walker A motif; other site
485915006411	ATP binding site [chemical binding]; other site
485915006412	Walker B motif; other site
485915006413	arginine finger; other site
485915006414	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
485915006415	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
485915006416	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
485915006417	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
485915006418	Walker A motif; other site
485915006419	ATP binding site [chemical binding]; other site
485915006420	Walker B motif; other site
485915006421	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
485915006422	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
485915006423	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
485915006424	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
485915006425	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
485915006426	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
485915006427	Transposase; Region: DDE_Tnp_ISL3; pfam01610
485915006428	Putative exonuclease, RdgC; Region: RdgC; cl01122
485915006429	thiamine monophosphate kinase; Provisional; Region: PRK05731
485915006430	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
485915006431	ATP binding site [chemical binding]; other site
485915006432	dimerization interface [polypeptide binding]; other site
485915006433	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
485915006434	Part of AAA domain; Region: AAA_19; pfam13245
485915006435	Family description; Region: UvrD_C_2; pfam13538
485915006436	HD domain; Region: HD_3; pfam13023
485915006437	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
485915006438	heterotetramer interface [polypeptide binding]; other site
485915006439	active site pocket [active]
485915006440	cleavage site
485915006441	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
485915006442	DEAD/DEAH box helicase; Region: DEAD; pfam00270
485915006443	ATP binding site [chemical binding]; other site
485915006444	putative Mg++ binding site [ion binding]; other site
485915006445	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
485915006446	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
485915006447	nucleotide binding region [chemical binding]; other site
485915006448	ATP-binding site [chemical binding]; other site
485915006449	SEC-C motif; Region: SEC-C; pfam02810
485915006450	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915006451	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
485915006452	FAD binding domain; Region: FAD_binding_4; pfam01565
485915006453	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
485915006454	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
485915006455	SmpB-tmRNA interface; other site
485915006456	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
485915006457	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
485915006458	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
485915006459	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
485915006460	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
485915006461	dimerization domain swap beta strand [polypeptide binding]; other site
485915006462	regulatory protein interface [polypeptide binding]; other site
485915006463	active site
485915006464	regulatory phosphorylation site [posttranslational modification]; other site
485915006465	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
485915006466	Predicted methyltransferases [General function prediction only]; Region: COG0313
485915006467	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
485915006468	putative SAM binding site [chemical binding]; other site
485915006469	putative homodimer interface [polypeptide binding]; other site
485915006470	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
485915006471	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
485915006472	RNA/DNA hybrid binding site [nucleotide binding]; other site
485915006473	active site
485915006474	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
485915006475	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
485915006476	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936
485915006477	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
485915006478	RimM N-terminal domain; Region: RimM; pfam01782
485915006479	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
485915006480	hypothetical protein; Provisional; Region: PRK00468
485915006481	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
485915006482	signal recognition particle protein; Provisional; Region: PRK10867
485915006483	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
485915006484	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
485915006485	P loop; other site
485915006486	GTP binding site [chemical binding]; other site
485915006487	Signal peptide binding domain; Region: SRP_SPB; pfam02978
485915006488	aspartate aminotransferase; Provisional; Region: PRK06836
485915006489	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
485915006490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915006491	homodimer interface [polypeptide binding]; other site
485915006492	catalytic residue [active]
485915006493	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
485915006494	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
485915006495	Walker A/P-loop; other site
485915006496	ATP binding site [chemical binding]; other site
485915006497	Q-loop/lid; other site
485915006498	ABC transporter signature motif; other site
485915006499	Walker B; other site
485915006500	D-loop; other site
485915006501	H-loop/switch region; other site
485915006502	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
485915006503	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
485915006504	substrate binding pocket [chemical binding]; other site
485915006505	membrane-bound complex binding site; other site
485915006506	hinge residues; other site
485915006507	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
485915006508	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915006509	dimer interface [polypeptide binding]; other site
485915006510	conserved gate region; other site
485915006511	putative PBP binding loops; other site
485915006512	ABC-ATPase subunit interface; other site
485915006513	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
485915006514	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915006515	dimer interface [polypeptide binding]; other site
485915006516	conserved gate region; other site
485915006517	putative PBP binding loops; other site
485915006518	ABC-ATPase subunit interface; other site
485915006519	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
485915006520	AIR carboxylase; Region: AIRC; smart01001
485915006521	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
485915006522	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
485915006523	putative ADP-binding pocket [chemical binding]; other site
485915006524	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
485915006525	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
485915006526	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537
485915006527	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
485915006528	active site
485915006529	nucleotide binding site [chemical binding]; other site
485915006530	HIGH motif; other site
485915006531	KMSKS motif; other site
485915006532	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
485915006533	ligand-binding site [chemical binding]; other site
485915006534	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
485915006535	catalytic loop [active]
485915006536	iron binding site [ion binding]; other site
485915006537	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
485915006538	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
485915006539	dimerization interface [polypeptide binding]; other site
485915006540	putative ATP binding site [chemical binding]; other site
485915006541	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
485915006542	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
485915006543	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
485915006544	putative dimerization interface [polypeptide binding]; other site
485915006545	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
485915006546	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
485915006547	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
485915006548	alphaNTD - beta interaction site [polypeptide binding]; other site
485915006549	alphaNTD homodimer interface [polypeptide binding]; other site
485915006550	alphaNTD - beta' interaction site [polypeptide binding]; other site
485915006551	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
485915006552	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
485915006553	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
485915006554	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
485915006555	RNA binding surface [nucleotide binding]; other site
485915006556	30S ribosomal protein S11; Validated; Region: PRK05309
485915006557	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
485915006558	30S ribosomal protein S13; Region: bact_S13; TIGR03631
485915006559	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
485915006560	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
485915006561	active site
485915006562	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
485915006563	SecY translocase; Region: SecY; pfam00344
485915006564	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
485915006565	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
485915006566	23S rRNA binding site [nucleotide binding]; other site
485915006567	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
485915006568	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
485915006569	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
485915006570	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
485915006571	23S rRNA interface [nucleotide binding]; other site
485915006572	5S rRNA interface [nucleotide binding]; other site
485915006573	L27 interface [polypeptide binding]; other site
485915006574	L5 interface [polypeptide binding]; other site
485915006575	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
485915006576	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
485915006577	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
485915006578	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
485915006579	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
485915006580	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
485915006581	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
485915006582	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
485915006583	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
485915006584	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
485915006585	RNA binding site [nucleotide binding]; other site
485915006586	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
485915006587	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
485915006588	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
485915006589	23S rRNA interface [nucleotide binding]; other site
485915006590	putative translocon interaction site; other site
485915006591	signal recognition particle (SRP54) interaction site; other site
485915006592	L23 interface [polypeptide binding]; other site
485915006593	trigger factor interaction site; other site
485915006594	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
485915006595	23S rRNA interface [nucleotide binding]; other site
485915006596	5S rRNA interface [nucleotide binding]; other site
485915006597	putative antibiotic binding site [chemical binding]; other site
485915006598	L25 interface [polypeptide binding]; other site
485915006599	L27 interface [polypeptide binding]; other site
485915006600	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
485915006601	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
485915006602	G-X-X-G motif; other site
485915006603	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
485915006604	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
485915006605	putative translocon binding site; other site
485915006606	protein-rRNA interface [nucleotide binding]; other site
485915006607	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
485915006608	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
485915006609	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
485915006610	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
485915006611	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
485915006612	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
485915006613	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
485915006614	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
485915006615	elongation factor Tu; Reviewed; Region: PRK00049
485915006616	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
485915006617	G1 box; other site
485915006618	GEF interaction site [polypeptide binding]; other site
485915006619	GTP/Mg2+ binding site [chemical binding]; other site
485915006620	Switch I region; other site
485915006621	G2 box; other site
485915006622	G3 box; other site
485915006623	Switch II region; other site
485915006624	G4 box; other site
485915006625	G5 box; other site
485915006626	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
485915006627	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
485915006628	Antibiotic Binding Site [chemical binding]; other site
485915006629	elongation factor G; Reviewed; Region: PRK00007
485915006630	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
485915006631	G1 box; other site
485915006632	putative GEF interaction site [polypeptide binding]; other site
485915006633	GTP/Mg2+ binding site [chemical binding]; other site
485915006634	Switch I region; other site
485915006635	G2 box; other site
485915006636	G3 box; other site
485915006637	Switch II region; other site
485915006638	G4 box; other site
485915006639	G5 box; other site
485915006640	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
485915006641	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
485915006642	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
485915006643	30S ribosomal protein S7; Validated; Region: PRK05302
485915006644	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
485915006645	S17 interaction site [polypeptide binding]; other site
485915006646	S8 interaction site; other site
485915006647	16S rRNA interaction site [nucleotide binding]; other site
485915006648	streptomycin interaction site [chemical binding]; other site
485915006649	23S rRNA interaction site [nucleotide binding]; other site
485915006650	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
485915006651	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
485915006652	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
485915006653	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
485915006654	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
485915006655	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
485915006656	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
485915006657	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
485915006658	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
485915006659	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
485915006660	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
485915006661	DNA binding site [nucleotide binding]
485915006662	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
485915006663	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
485915006664	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
485915006665	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
485915006666	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
485915006667	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
485915006668	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
485915006669	RPB3 interaction site [polypeptide binding]; other site
485915006670	RPB1 interaction site [polypeptide binding]; other site
485915006671	RPB11 interaction site [polypeptide binding]; other site
485915006672	RPB10 interaction site [polypeptide binding]; other site
485915006673	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
485915006674	core dimer interface [polypeptide binding]; other site
485915006675	peripheral dimer interface [polypeptide binding]; other site
485915006676	L10 interface [polypeptide binding]; other site
485915006677	L11 interface [polypeptide binding]; other site
485915006678	putative EF-Tu interaction site [polypeptide binding]; other site
485915006679	putative EF-G interaction site [polypeptide binding]; other site
485915006680	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
485915006681	23S rRNA interface [nucleotide binding]; other site
485915006682	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
485915006683	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
485915006684	mRNA/rRNA interface [nucleotide binding]; other site
485915006685	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
485915006686	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
485915006687	23S rRNA interface [nucleotide binding]; other site
485915006688	L7/L12 interface [polypeptide binding]; other site
485915006689	putative thiostrepton binding site; other site
485915006690	L25 interface [polypeptide binding]; other site
485915006691	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
485915006692	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
485915006693	putative homodimer interface [polypeptide binding]; other site
485915006694	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
485915006695	heterodimer interface [polypeptide binding]; other site
485915006696	homodimer interface [polypeptide binding]; other site
485915006697	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
485915006698	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
485915006699	elongation factor Tu; Reviewed; Region: PRK00049
485915006700	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
485915006701	G1 box; other site
485915006702	GEF interaction site [polypeptide binding]; other site
485915006703	GTP/Mg2+ binding site [chemical binding]; other site
485915006704	Switch I region; other site
485915006705	G2 box; other site
485915006706	G3 box; other site
485915006707	Switch II region; other site
485915006708	G4 box; other site
485915006709	G5 box; other site
485915006710	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
485915006711	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
485915006712	Antibiotic Binding Site [chemical binding]; other site
485915006713	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
485915006714	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
485915006715	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
485915006716	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915006717	S-adenosylmethionine binding site [chemical binding]; other site
485915006718	peptide chain release factor 1; Validated; Region: prfA; PRK00591
485915006719	This domain is found in peptide chain release factors; Region: PCRF; smart00937
485915006720	RF-1 domain; Region: RF-1; pfam00472
485915006721	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
485915006722	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
485915006723	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
485915006724	CoA binding domain; Region: CoA_binding; pfam02629
485915006725	ATP synthase subunit C; Region: ATP-synt_C; cl00466
485915006726	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
485915006727	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
485915006728	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
485915006729	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
485915006730	Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947
485915006731	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
485915006732	active site
485915006733	catalytic residues [active]
485915006734	metal binding site [ion binding]; metal-binding site
485915006735	Cache domain; Region: Cache_1; pfam02743
485915006736	hypothetical protein; Provisional; Region: PRK08328
485915006737	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
485915006738	ATP binding site [chemical binding]; other site
485915006739	substrate interface [chemical binding]; other site
485915006740	glycerol kinase; Provisional; Region: glpK; PRK00047
485915006741	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
485915006742	N- and C-terminal domain interface [polypeptide binding]; other site
485915006743	active site
485915006744	MgATP binding site [chemical binding]; other site
485915006745	catalytic site [active]
485915006746	metal binding site [ion binding]; metal-binding site
485915006747	putative homotetramer interface [polypeptide binding]; other site
485915006748	glycerol binding site [chemical binding]; other site
485915006749	homodimer interface [polypeptide binding]; other site
485915006750	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
485915006751	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
485915006752	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
485915006753	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915006754	dimer interface [polypeptide binding]; other site
485915006755	conserved gate region; other site
485915006756	putative PBP binding loops; other site
485915006757	ABC-ATPase subunit interface; other site
485915006758	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915006759	dimer interface [polypeptide binding]; other site
485915006760	conserved gate region; other site
485915006761	ABC-ATPase subunit interface; other site
485915006762	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
485915006763	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
485915006764	Walker A/P-loop; other site
485915006765	ATP binding site [chemical binding]; other site
485915006766	Q-loop/lid; other site
485915006767	ABC transporter signature motif; other site
485915006768	Walker B; other site
485915006769	D-loop; other site
485915006770	H-loop/switch region; other site
485915006771	TOBE domain; Region: TOBE_2; pfam08402
485915006772	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
485915006773	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
485915006774	Walker A/P-loop; other site
485915006775	ATP binding site [chemical binding]; other site
485915006776	Q-loop/lid; other site
485915006777	ABC transporter signature motif; other site
485915006778	Walker B; other site
485915006779	D-loop; other site
485915006780	H-loop/switch region; other site
485915006781	TOBE domain; Region: TOBE_2; pfam08402
485915006782	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
485915006783	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
485915006784	glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377
485915006785	hydroxyglutarate oxidase; Provisional; Region: PRK11728
485915006786	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
485915006787	thiamine phosphate binding site [chemical binding]; other site
485915006788	active site
485915006789	pyrophosphate binding site [ion binding]; other site
485915006790	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
485915006791	substrate binding site [chemical binding]; other site
485915006792	multimerization interface [polypeptide binding]; other site
485915006793	ATP binding site [chemical binding]; other site
485915006794	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
485915006795	Protein of unknown function, DUF606; Region: DUF606; pfam04657
485915006796	Uncharacterized conserved protein [Function unknown]; Region: COG1284
485915006797	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
485915006798	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
485915006799	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
485915006800	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
485915006801	Uncharacterized conserved protein [Function unknown]; Region: COG0432
485915006802	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
485915006803	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
485915006804	dimer interface [polypeptide binding]; other site
485915006805	putative functional site; other site
485915006806	putative MPT binding site; other site
485915006807	PBP superfamily domain; Region: PBP_like; pfam12727
485915006808	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
485915006809	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
485915006810	dimerization interface 3.5A [polypeptide binding]; other site
485915006811	active site
485915006812	ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214
485915006813	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
485915006814	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
485915006815	sepiapterin reductase; Region: sepiapter_red; TIGR01500
485915006816	NAD(P) binding site [chemical binding]; other site
485915006817	active site
485915006818	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830
485915006819	active site
485915006820	ADP/pyrophosphate binding site [chemical binding]; other site
485915006821	dimerization interface [polypeptide binding]; other site
485915006822	allosteric effector site; other site
485915006823	fructose-1,6-bisphosphate binding site; other site
485915006824	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
485915006825	TPR motif; other site
485915006826	binding surface
485915006827	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
485915006828	Major Facilitator Superfamily; Region: MFS_1; pfam07690
485915006829	putative substrate translocation pore; other site
485915006830	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
485915006831	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
485915006832	Phosphotransferase enzyme family; Region: APH; pfam01636
485915006833	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
485915006834	active site
485915006835	substrate binding site [chemical binding]; other site
485915006836	ATP binding site [chemical binding]; other site
485915006837	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
485915006838	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
485915006839	Walker A/P-loop; other site
485915006840	ATP binding site [chemical binding]; other site
485915006841	Q-loop/lid; other site
485915006842	ABC transporter signature motif; other site
485915006843	Walker B; other site
485915006844	D-loop; other site
485915006845	H-loop/switch region; other site
485915006846	TOBE domain; Region: TOBE_2; pfam08402
485915006847	hypothetical protein; Provisional; Region: PRK11622
485915006848	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
485915006849	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915006850	putative PBP binding loops; other site
485915006851	dimer interface [polypeptide binding]; other site
485915006852	ABC-ATPase subunit interface; other site
485915006853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
485915006854	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
485915006855	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
485915006856	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
485915006857	putative active site [active]
485915006858	catalytic site [active]
485915006859	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
485915006860	putative active site [active]
485915006861	catalytic site [active]
485915006862	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
485915006863	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
485915006864	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
485915006865	putative ADP-binding pocket [chemical binding]; other site
485915006866	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
485915006867	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
485915006868	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
485915006869	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915006870	Walker A/P-loop; other site
485915006871	ATP binding site [chemical binding]; other site
485915006872	Q-loop/lid; other site
485915006873	ABC transporter signature motif; other site
485915006874	Walker B; other site
485915006875	D-loop; other site
485915006876	H-loop/switch region; other site
485915006877	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
485915006878	CoA binding domain; Region: CoA_binding_2; pfam13380
485915006879	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
485915006880	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
485915006881	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
485915006882	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
485915006883	acetyl-CoA synthetase; Provisional; Region: PRK00174
485915006884	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
485915006885	active site
485915006886	CoA binding site [chemical binding]; other site
485915006887	acyl-activating enzyme (AAE) consensus motif; other site
485915006888	AMP binding site [chemical binding]; other site
485915006889	acetate binding site [chemical binding]; other site
485915006890	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
485915006891	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
485915006892	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
485915006893	ribonuclease R; Region: RNase_R; TIGR02063
485915006894	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
485915006895	RNB domain; Region: RNB; pfam00773
485915006896	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
485915006897	RNA binding site [nucleotide binding]; other site
485915006898	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
485915006899	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
485915006900	trmE is a tRNA modification GTPase; Region: trmE; cd04164
485915006901	G1 box; other site
485915006902	GTP/Mg2+ binding site [chemical binding]; other site
485915006903	Switch I region; other site
485915006904	G2 box; other site
485915006905	Switch II region; other site
485915006906	G3 box; other site
485915006907	G4 box; other site
485915006908	G5 box; other site
485915006909	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
485915006910	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
485915006911	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
485915006912	G-X-X-G motif; other site
485915006913	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
485915006914	RxxxH motif; other site
485915006915	membrane protein insertase; Provisional; Region: PRK01318
485915006916	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
485915006917	Haemolytic domain; Region: Haemolytic; pfam01809
485915006918	Ribonuclease P; Region: Ribonuclease_P; pfam00825
485915006919	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
485915006920	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
485915006921	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
485915006922	active site
485915006923	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
485915006924	Ligand binding site; other site
485915006925	Putative Catalytic site; other site
485915006926	DXD motif; other site
485915006927	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
485915006928	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
485915006929	putative metal binding site [ion binding]; other site
485915006930	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
485915006931	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
485915006932	ABC-ATPase subunit  interface; other site
485915006933	dimer interface [polypeptide binding]; other site
485915006934	putative PBP binding regions; other site
485915006935	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
485915006936	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
485915006937	Walker A/P-loop; other site
485915006938	ATP binding site [chemical binding]; other site
485915006939	Q-loop/lid; other site
485915006940	ABC transporter signature motif; other site
485915006941	Walker B; other site
485915006942	D-loop; other site
485915006943	H-loop/switch region; other site
485915006944	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
485915006945	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
485915006946	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
485915006947	acetylornithine aminotransferase; Provisional; Region: PRK02627
485915006948	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
485915006949	inhibitor-cofactor binding pocket; inhibition site
485915006950	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915006951	catalytic residue [active]
485915006952	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
485915006953	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
485915006954	Walker A/P-loop; other site
485915006955	ATP binding site [chemical binding]; other site
485915006956	Q-loop/lid; other site
485915006957	ABC transporter signature motif; other site
485915006958	Walker B; other site
485915006959	D-loop; other site
485915006960	H-loop/switch region; other site
485915006961	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
485915006962	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
485915006963	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
485915006964	substrate binding pocket [chemical binding]; other site
485915006965	membrane-bound complex binding site; other site
485915006966	hinge residues; other site
485915006967	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
485915006968	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915006969	dimer interface [polypeptide binding]; other site
485915006970	conserved gate region; other site
485915006971	putative PBP binding loops; other site
485915006972	ABC-ATPase subunit interface; other site
485915006973	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
485915006974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915006975	dimer interface [polypeptide binding]; other site
485915006976	conserved gate region; other site
485915006977	putative PBP binding loops; other site
485915006978	ABC-ATPase subunit interface; other site
485915006979	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
485915006980	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915006981	S-adenosylmethionine binding site [chemical binding]; other site
485915006982	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
485915006983	minor groove reading motif; other site
485915006984	helix-hairpin-helix signature motif; other site
485915006985	substrate binding pocket [chemical binding]; other site
485915006986	active site
485915006987	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
485915006988	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
485915006989	Peptidase family M23; Region: Peptidase_M23; pfam01551
485915006990	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
485915006991	C-terminal peptidase (prc); Region: prc; TIGR00225
485915006992	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
485915006993	protein binding site [polypeptide binding]; other site
485915006994	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
485915006995	Catalytic dyad [active]
485915006996	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
485915006997	NodB motif; other site
485915006998	putative active site [active]
485915006999	putative catalytic site [active]
485915007000	Zn binding site [ion binding]; other site
485915007001	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
485915007002	zinc binding site [ion binding]; other site
485915007003	putative ligand binding site [chemical binding]; other site
485915007004	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
485915007005	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
485915007006	TM-ABC transporter signature motif; other site
485915007007	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
485915007008	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915007009	Walker A/P-loop; other site
485915007010	ATP binding site [chemical binding]; other site
485915007011	Q-loop/lid; other site
485915007012	ABC transporter signature motif; other site
485915007013	Walker B; other site
485915007014	D-loop; other site
485915007015	H-loop/switch region; other site
485915007016	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
485915007017	active site
485915007018	multimer interface [polypeptide binding]; other site
485915007019	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
485915007020	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
485915007021	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
485915007022	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
485915007023	Aspartase; Region: Aspartase; cd01357
485915007024	active sites [active]
485915007025	tetramer interface [polypeptide binding]; other site
485915007026	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
485915007027	trimer interface [polypeptide binding]; other site
485915007028	active site
485915007029	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
485915007030	putative homodimer interface [polypeptide binding]; other site
485915007031	putative active site pocket [active]
485915007032	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
485915007033	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
485915007034	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
485915007035	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
485915007036	Tetramer interface [polypeptide binding]; other site
485915007037	active site
485915007038	FMN-binding site [chemical binding]; other site
485915007039	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
485915007040	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
485915007041	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
485915007042	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
485915007043	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
485915007044	oligomerisation interface [polypeptide binding]; other site
485915007045	mobile loop; other site
485915007046	roof hairpin; other site
485915007047	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
485915007048	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
485915007049	ring oligomerisation interface [polypeptide binding]; other site
485915007050	ATP/Mg binding site [chemical binding]; other site
485915007051	stacking interactions; other site
485915007052	hinge regions; other site
485915007053	4Fe-4S binding domain; Region: Fer4; pfam00037
485915007054	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
485915007055	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
485915007056	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
485915007057	Zn2+ binding site [ion binding]; other site
485915007058	Mg2+ binding site [ion binding]; other site
485915007059	gamma-glutamyl kinase; Provisional; Region: PRK05429
485915007060	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
485915007061	nucleotide binding site [chemical binding]; other site
485915007062	homotetrameric interface [polypeptide binding]; other site
485915007063	putative phosphate binding site [ion binding]; other site
485915007064	putative allosteric binding site; other site
485915007065	PUA domain; Region: PUA; pfam01472
485915007066	GTPase CgtA; Reviewed; Region: obgE; PRK12299
485915007067	GTP1/OBG; Region: GTP1_OBG; pfam01018
485915007068	Obg GTPase; Region: Obg; cd01898
485915007069	G1 box; other site
485915007070	GTP/Mg2+ binding site [chemical binding]; other site
485915007071	Switch I region; other site
485915007072	G2 box; other site
485915007073	G3 box; other site
485915007074	Switch II region; other site
485915007075	G4 box; other site
485915007076	G5 box; other site
485915007077	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
485915007078	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
485915007079	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
485915007080	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
485915007081	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
485915007082	active site
485915007083	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
485915007084	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
485915007085	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
485915007086	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
485915007087	putative FMN binding site [chemical binding]; other site
485915007088	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915007089	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915007090	metal binding site [ion binding]; metal-binding site
485915007091	active site
485915007092	I-site; other site
485915007093	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915007094	I-site; other site
485915007095	active site
485915007096	metal binding site [ion binding]; metal-binding site
485915007097	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915007098	TPR motif; other site
485915007099	TPR repeat; Region: TPR_11; pfam13414
485915007100	binding surface
485915007101	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915007102	binding surface
485915007103	TPR motif; other site
485915007104	Tetratricopeptide repeat; Region: TPR_16; pfam13432
485915007105	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
485915007106	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
485915007107	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
485915007108	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
485915007109	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
485915007110	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
485915007111	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915007112	FeS/SAM binding site; other site
485915007113	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
485915007114	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
485915007115	Colicin V production protein; Region: Colicin_V; pfam02674
485915007116	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
485915007117	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
485915007118	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
485915007119	homodimer interface [polypeptide binding]; other site
485915007120	metal binding site [ion binding]; metal-binding site
485915007121	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
485915007122	homodimer interface [polypeptide binding]; other site
485915007123	active site
485915007124	putative chemical substrate binding site [chemical binding]; other site
485915007125	metal binding site [ion binding]; metal-binding site
485915007126	cytidylate kinase; Provisional; Region: cmk; PRK00023
485915007127	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
485915007128	CMP-binding site; other site
485915007129	The sites determining sugar specificity; other site
485915007130	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
485915007131	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
485915007132	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915007133	homodimer interface [polypeptide binding]; other site
485915007134	catalytic residue [active]
485915007135	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
485915007136	Secretin and TonB N terminus short domain; Region: STN; pfam07660
485915007137	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
485915007138	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
485915007139	Pilus assembly protein, PilP; Region: PilP; pfam04351
485915007140	Pilus assembly protein, PilO; Region: PilO; cl01234
485915007141	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
485915007142	Competence protein A; Region: Competence_A; pfam11104
485915007143	Cell division protein FtsA; Region: FtsA; pfam14450
485915007144	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
485915007145	Ligand Binding Site [chemical binding]; other site
485915007146	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
485915007147	UbiA prenyltransferase family; Region: UbiA; pfam01040
485915007148	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
485915007149	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
485915007150	active site
485915007151	HIGH motif; other site
485915007152	dimer interface [polypeptide binding]; other site
485915007153	KMSKS motif; other site
485915007154	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
485915007155	RNA binding surface [nucleotide binding]; other site
485915007156	phosphodiesterase; Provisional; Region: PRK12704
485915007157	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
485915007158	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
485915007159	Zn2+ binding site [ion binding]; other site
485915007160	Mg2+ binding site [ion binding]; other site
485915007161	Cell division protein ZapA; Region: ZapA; pfam05164
485915007162	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14356
485915007163	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
485915007164	Substrate binding site; other site
485915007165	Mg++ binding site; other site
485915007166	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
485915007167	active site
485915007168	substrate binding site [chemical binding]; other site
485915007169	CoA binding site [chemical binding]; other site
485915007170	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446
485915007171	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
485915007172	gamma subunit interface [polypeptide binding]; other site
485915007173	epsilon subunit interface [polypeptide binding]; other site
485915007174	LBP interface [polypeptide binding]; other site
485915007175	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
485915007176	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
485915007177	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
485915007178	alpha subunit interaction interface [polypeptide binding]; other site
485915007179	Walker A motif; other site
485915007180	ATP binding site [chemical binding]; other site
485915007181	Walker B motif; other site
485915007182	inhibitor binding site; inhibition site
485915007183	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
485915007184	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
485915007185	core domain interface [polypeptide binding]; other site
485915007186	delta subunit interface [polypeptide binding]; other site
485915007187	epsilon subunit interface [polypeptide binding]; other site
485915007188	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
485915007189	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
485915007190	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
485915007191	beta subunit interaction interface [polypeptide binding]; other site
485915007192	Walker A motif; other site
485915007193	ATP binding site [chemical binding]; other site
485915007194	Walker B motif; other site
485915007195	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
485915007196	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
485915007197	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
485915007198	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
485915007199	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
485915007200	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
485915007201	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
485915007202	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
485915007203	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
485915007204	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
485915007205	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
485915007206	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
485915007207	rod shape-determining protein MreC; Provisional; Region: PRK13922
485915007208	rod shape-determining protein MreC; Region: MreC; pfam04085
485915007209	rod shape-determining protein MreB; Provisional; Region: PRK13927
485915007210	MreB and similar proteins; Region: MreB_like; cd10225
485915007211	nucleotide binding site [chemical binding]; other site
485915007212	Mg binding site [ion binding]; other site
485915007213	putative protofilament interaction site [polypeptide binding]; other site
485915007214	RodZ interaction site [polypeptide binding]; other site
485915007215	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
485915007216	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
485915007217	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
485915007218	DNA binding site [nucleotide binding]
485915007219	active site
485915007220	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
485915007221	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
485915007222	Walker A/P-loop; other site
485915007223	ATP binding site [chemical binding]; other site
485915007224	Q-loop/lid; other site
485915007225	ABC transporter signature motif; other site
485915007226	Walker B; other site
485915007227	D-loop; other site
485915007228	H-loop/switch region; other site
485915007229	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
485915007230	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
485915007231	Walker A/P-loop; other site
485915007232	ATP binding site [chemical binding]; other site
485915007233	Q-loop/lid; other site
485915007234	ABC transporter signature motif; other site
485915007235	Walker B; other site
485915007236	D-loop; other site
485915007237	H-loop/switch region; other site
485915007238	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
485915007239	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
485915007240	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
485915007241	active site
485915007242	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
485915007243	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
485915007244	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
485915007245	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
485915007246	trimer interface [polypeptide binding]; other site
485915007247	active site
485915007248	UDP-GlcNAc binding site [chemical binding]; other site
485915007249	lipid binding site [chemical binding]; lipid-binding site
485915007250	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
485915007251	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
485915007252	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
485915007253	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
485915007254	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
485915007255	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
485915007256	Surface antigen; Region: Bac_surface_Ag; pfam01103
485915007257	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
485915007258	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
485915007259	Walker A/P-loop; other site
485915007260	ATP binding site [chemical binding]; other site
485915007261	Q-loop/lid; other site
485915007262	ABC transporter signature motif; other site
485915007263	Walker B; other site
485915007264	D-loop; other site
485915007265	H-loop/switch region; other site
485915007266	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
485915007267	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
485915007268	FtsX-like permease family; Region: FtsX; pfam02687
485915007269	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
485915007270	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
485915007271	dimer interface [polypeptide binding]; other site
485915007272	putative anticodon binding site; other site
485915007273	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
485915007274	motif 1; other site
485915007275	active site
485915007276	motif 2; other site
485915007277	motif 3; other site
485915007278	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
485915007279	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
485915007280	Sporulation related domain; Region: SPOR; pfam05036
485915007281	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
485915007282	IHF - DNA interface [nucleotide binding]; other site
485915007283	IHF dimer interface [polypeptide binding]; other site
485915007284	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
485915007285	HIT family signature motif; other site
485915007286	catalytic residue [active]
485915007287	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915007288	FeS/SAM binding site; other site
485915007289	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
485915007290	Amidohydrolase; Region: Amidohydro_4; pfam13147
485915007291	active site
485915007292	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
485915007293	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
485915007294	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
485915007295	dihydroorotase; Validated; Region: pyrC; PRK09357
485915007296	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
485915007297	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
485915007298	active site
485915007299	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
485915007300	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915007301	active site
485915007302	phosphorylation site [posttranslational modification]
485915007303	intermolecular recognition site; other site
485915007304	dimerization interface [polypeptide binding]; other site
485915007305	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915007306	Walker A motif; other site
485915007307	ATP binding site [chemical binding]; other site
485915007308	Walker B motif; other site
485915007309	arginine finger; other site
485915007310	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915007311	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14460
485915007312	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915007313	FeS/SAM binding site; other site
485915007314	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
485915007315	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
485915007316	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
485915007317	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
485915007318	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915007319	binding surface
485915007320	TPR motif; other site
485915007321	Tetratricopeptide repeat; Region: TPR_12; pfam13424
485915007322	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
485915007323	binding surface
485915007324	TPR motif; other site
485915007325	B12 binding domain; Region: B12-binding; pfam02310
485915007326	B12 binding site [chemical binding]; other site
485915007327	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
485915007328	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
485915007329	FeS/SAM binding site; other site
485915007330	GTP-binding protein LepA; Provisional; Region: PRK05433
485915007331	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
485915007332	G1 box; other site
485915007333	putative GEF interaction site [polypeptide binding]; other site
485915007334	GTP/Mg2+ binding site [chemical binding]; other site
485915007335	Switch I region; other site
485915007336	G2 box; other site
485915007337	G3 box; other site
485915007338	Switch II region; other site
485915007339	G4 box; other site
485915007340	G5 box; other site
485915007341	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
485915007342	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
485915007343	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
485915007344	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
485915007345	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
485915007346	Catalytic site [active]
485915007347	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
485915007348	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
485915007349	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915007350	Walker A motif; other site
485915007351	ATP binding site [chemical binding]; other site
485915007352	Walker B motif; other site
485915007353	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
485915007354	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
485915007355	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
485915007356	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
485915007357	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
485915007358	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
485915007359	domain interfaces; other site
485915007360	active site
485915007361	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
485915007362	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
485915007363	active site
485915007364	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
485915007365	active site 2 [active]
485915007366	active site 1 [active]
485915007367	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
485915007368	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
485915007369	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
485915007370	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
485915007371	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
485915007372	active site residue [active]
485915007373	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
485915007374	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
485915007375	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518
485915007376	nickel binding site [ion binding]; other site
485915007377	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
485915007378	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
485915007379	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
485915007380	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
485915007381	4Fe-4S binding domain; Region: Fer4; pfam00037
485915007382	4Fe-4S binding domain; Region: Fer4_6; pfam12837
485915007383	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831
485915007384	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
485915007385	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
485915007386	Soluble P-type ATPase [General function prediction only]; Region: COG4087
485915007387	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
485915007388	dimerization interface [polypeptide binding]; other site
485915007389	putative DNA binding site [nucleotide binding]; other site
485915007390	putative Zn2+ binding site [ion binding]; other site
485915007391	Uncharacterized conserved protein [Function unknown]; Region: COG1284
485915007392	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
485915007393	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
485915007394	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
485915007395	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
485915007396	methionine sulfoxide reductase B; Provisional; Region: PRK00222
485915007397	SelR domain; Region: SelR; pfam01641
485915007398	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
485915007399	Peptidase family M23; Region: Peptidase_M23; pfam01551
485915007400	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
485915007401	homodimer interaction site [polypeptide binding]; other site
485915007402	cofactor binding site; other site
485915007403	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
485915007404	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
485915007405	Nitrogen regulatory protein P-II; Region: P-II; smart00938
485915007406	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
485915007407	UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844
485915007408	metal binding triad; other site
485915007409	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
485915007410	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503
485915007411	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
485915007412	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
485915007413	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
485915007414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915007415	dimer interface [polypeptide binding]; other site
485915007416	conserved gate region; other site
485915007417	putative PBP binding loops; other site
485915007418	ABC-ATPase subunit interface; other site
485915007419	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
485915007420	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
485915007421	Walker A/P-loop; other site
485915007422	ATP binding site [chemical binding]; other site
485915007423	Q-loop/lid; other site
485915007424	ABC transporter signature motif; other site
485915007425	Walker B; other site
485915007426	D-loop; other site
485915007427	H-loop/switch region; other site
485915007428	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
485915007429	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
485915007430	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
485915007431	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
485915007432	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
485915007433	active site
485915007434	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
485915007435	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
485915007436	active site
485915007437	nucleotide binding site [chemical binding]; other site
485915007438	HIGH motif; other site
485915007439	KMSKS motif; other site
485915007440	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
485915007441	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
485915007442	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
485915007443	Walker A motif; other site
485915007444	ATP binding site [chemical binding]; other site
485915007445	Walker B motif; other site
485915007446	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
485915007447	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
485915007448	active site
485915007449	NAD binding site [chemical binding]; other site
485915007450	metal binding site [ion binding]; metal-binding site
485915007451	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
485915007452	Ligand Binding Site [chemical binding]; other site
485915007453	Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834
485915007454	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
485915007455	purine monophosphate binding site [chemical binding]; other site
485915007456	dimer interface [polypeptide binding]; other site
485915007457	putative catalytic residues [active]
485915007458	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
485915007459	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
485915007460	HflX GTPase family; Region: HflX; cd01878
485915007461	G1 box; other site
485915007462	GTP/Mg2+ binding site [chemical binding]; other site
485915007463	Switch I region; other site
485915007464	G2 box; other site
485915007465	G3 box; other site
485915007466	Switch II region; other site
485915007467	G4 box; other site
485915007468	G5 box; other site
485915007469	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
485915007470	RNB domain; Region: RNB; pfam00773
485915007471	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
485915007472	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
485915007473	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
485915007474	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
485915007475	N-acetyl-D-glucosamine binding site [chemical binding]; other site
485915007476	catalytic residue [active]
485915007477	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
485915007478	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
485915007479	GDP-binding site [chemical binding]; other site
485915007480	ACT binding site; other site
485915007481	IMP binding site; other site
485915007482	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
485915007483	DNA polymerase III subunit delta'; Validated; Region: PRK08485
485915007484	YibE/F-like protein; Region: YibE_F; pfam07907
485915007485	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
485915007486	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
485915007487	active site
485915007488	dimer interface [polypeptide binding]; other site
485915007489	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
485915007490	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
485915007491	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
485915007492	dimer interface [polypeptide binding]; other site
485915007493	substrate binding site [chemical binding]; other site
485915007494	ATP binding site [chemical binding]; other site
485915007495	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
485915007496	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
485915007497	Walker A/P-loop; other site
485915007498	ATP binding site [chemical binding]; other site
485915007499	Q-loop/lid; other site
485915007500	ABC transporter signature motif; other site
485915007501	Walker B; other site
485915007502	D-loop; other site
485915007503	H-loop/switch region; other site
485915007504	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
485915007505	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915007506	dimer interface [polypeptide binding]; other site
485915007507	conserved gate region; other site
485915007508	putative PBP binding loops; other site
485915007509	ABC-ATPase subunit interface; other site
485915007510	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
485915007511	NMT1/THI5 like; Region: NMT1; pfam09084
485915007512	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
485915007513	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
485915007514	putative active site [active]
485915007515	putative NTP binding site [chemical binding]; other site
485915007516	putative nucleic acid binding site [nucleotide binding]; other site
485915007517	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
485915007518	S-adenosylmethionine synthetase; Validated; Region: PRK05250
485915007519	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
485915007520	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
485915007521	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
485915007522	Adenosylhomocysteinase; Provisional; Region: PTZ00075
485915007523	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
485915007524	homotetramer interface [polypeptide binding]; other site
485915007525	ligand binding site [chemical binding]; other site
485915007526	catalytic site [active]
485915007527	NAD binding site [chemical binding]; other site
485915007528	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
485915007529	dimerization interface [polypeptide binding]; other site
485915007530	putative DNA binding site [nucleotide binding]; other site
485915007531	putative Zn2+ binding site [ion binding]; other site
485915007532	Replication protein C N-terminal domain; Region: RP-C; pfam03428
485915007533	Methyltransferase domain; Region: Methyltransf_23; pfam13489
485915007534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915007535	S-adenosylmethionine binding site [chemical binding]; other site
485915007536	Protein of unknown function (DUF721); Region: DUF721; pfam05258
485915007537	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
485915007538	Uncharacterized conserved protein [Function unknown]; Region: COG3287
485915007539	FIST N domain; Region: FIST; pfam08495
485915007540	FIST C domain; Region: FIST_C; pfam10442
485915007541	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
485915007542	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915007543	dimer interface [polypeptide binding]; other site
485915007544	phosphorylation site [posttranslational modification]
485915007545	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915007546	ATP binding site [chemical binding]; other site
485915007547	Mg2+ binding site [ion binding]; other site
485915007548	G-X-G motif; other site
485915007549	Response regulator receiver domain; Region: Response_reg; pfam00072
485915007550	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915007551	active site
485915007552	phosphorylation site [posttranslational modification]
485915007553	intermolecular recognition site; other site
485915007554	dimerization interface [polypeptide binding]; other site
485915007555	succinic semialdehyde dehydrogenase; Region: PLN02278
485915007556	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
485915007557	tetramerization interface [polypeptide binding]; other site
485915007558	NAD(P) binding site [chemical binding]; other site
485915007559	catalytic residues [active]
485915007560	pyruvate carboxylase; Reviewed; Region: PRK12999
485915007561	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
485915007562	ATP-grasp domain; Region: ATP-grasp_4; cl17255
485915007563	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
485915007564	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
485915007565	active site
485915007566	catalytic residues [active]
485915007567	metal binding site [ion binding]; metal-binding site
485915007568	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
485915007569	carboxyltransferase (CT) interaction site; other site
485915007570	biotinylation site [posttranslational modification]; other site
485915007571	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
485915007572	active site
485915007573	intersubunit interface [polypeptide binding]; other site
485915007574	zinc binding site [ion binding]; other site
485915007575	Uncharacterized conserved protein [Function unknown]; Region: COG1633
485915007576	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
485915007577	diiron binding motif [ion binding]; other site
485915007578	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
485915007579	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
485915007580	FAD binding pocket [chemical binding]; other site
485915007581	FAD binding motif [chemical binding]; other site
485915007582	phosphate binding motif [ion binding]; other site
485915007583	beta-alpha-beta structure motif; other site
485915007584	NAD binding pocket [chemical binding]; other site
485915007585	Iron coordination center [ion binding]; other site
485915007586	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
485915007587	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
485915007588	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
485915007589	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915007590	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
485915007591	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
485915007592	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
485915007593	4Fe-4S binding domain; Region: Fer4; pfam00037
485915007594	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
485915007595	Cysteine-rich domain; Region: CCG; pfam02754
485915007596	Cysteine-rich domain; Region: CCG; pfam02754
485915007597	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915007598	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
485915007599	ThiS family; Region: ThiS; pfam02597
485915007600	charged pocket; other site
485915007601	hydrophobic patch; other site
485915007602	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
485915007603	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
485915007604	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
485915007605	DctM-like transporters; Region: DctM; pfam06808
485915007606	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
485915007607	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
485915007608	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
485915007609	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
485915007610	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
485915007611	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
485915007612	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
485915007613	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
485915007614	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
485915007615	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
485915007616	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
485915007617	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915007618	Walker A motif; other site
485915007619	ATP binding site [chemical binding]; other site
485915007620	Walker B motif; other site
485915007621	arginine finger; other site
485915007622	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915007623	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
485915007624	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
485915007625	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
485915007626	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
485915007627	ligand binding site [chemical binding]; other site
485915007628	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
485915007629	PAS domain S-box; Region: sensory_box; TIGR00229
485915007630	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915007631	putative active site [active]
485915007632	heme pocket [chemical binding]; other site
485915007633	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915007634	PAS fold; Region: PAS_3; pfam08447
485915007635	putative active site [active]
485915007636	heme pocket [chemical binding]; other site
485915007637	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915007638	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915007639	metal binding site [ion binding]; metal-binding site
485915007640	active site
485915007641	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
485915007642	I-site; other site
485915007643	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
485915007644	Zn2+ binding site [ion binding]; other site
485915007645	Mg2+ binding site [ion binding]; other site
485915007646	PAS domain S-box; Region: sensory_box; TIGR00229
485915007647	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915007648	putative active site [active]
485915007649	heme pocket [chemical binding]; other site
485915007650	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915007651	PAS domain; Region: PAS_9; pfam13426
485915007652	putative active site [active]
485915007653	heme pocket [chemical binding]; other site
485915007654	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915007655	PAS fold; Region: PAS_4; pfam08448
485915007656	putative active site [active]
485915007657	heme pocket [chemical binding]; other site
485915007658	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915007659	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915007660	metal binding site [ion binding]; metal-binding site
485915007661	active site
485915007662	I-site; other site
485915007663	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
485915007664	CoenzymeA binding site [chemical binding]; other site
485915007665	subunit interaction site [polypeptide binding]; other site
485915007666	PHB binding site; other site
485915007667	Nif-specific regulatory protein; Region: nifA; TIGR01817
485915007668	GAF domain; Region: GAF_3; pfam13492
485915007669	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915007670	Walker A motif; other site
485915007671	ATP binding site [chemical binding]; other site
485915007672	Walker B motif; other site
485915007673	arginine finger; other site
485915007674	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915007675	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
485915007676	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
485915007677	HlyD family secretion protein; Region: HlyD_3; pfam13437
485915007678	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
485915007679	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
485915007680	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
485915007681	Bacterial SH3 domain; Region: SH3_3; cl17532
485915007682	FOG: WD40 repeat [General function prediction only]; Region: COG2319
485915007683	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
485915007684	structural tetrad; other site
485915007685	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
485915007686	Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497
485915007687	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
485915007688	protein binding site [polypeptide binding]; other site
485915007689	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
485915007690	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
485915007691	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
485915007692	putative dimer interface [polypeptide binding]; other site
485915007693	CAAX protease self-immunity; Region: Abi; pfam02517
485915007694	Beta/Gamma crystallin; Region: Crystall; cl02528
485915007695	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
485915007696	Major Facilitator Superfamily; Region: MFS_1; pfam07690
485915007697	putative substrate translocation pore; other site
485915007698	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
485915007699	dimerization interface [polypeptide binding]; other site
485915007700	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
485915007701	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915007702	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915007703	metal binding site [ion binding]; metal-binding site
485915007704	active site
485915007705	I-site; other site
485915007706	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
485915007707	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
485915007708	PAS domain; Region: PAS; smart00091
485915007709	PAS domain; Region: PAS_9; pfam13426
485915007710	putative active site [active]
485915007711	heme pocket [chemical binding]; other site
485915007712	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
485915007713	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915007714	Walker A motif; other site
485915007715	ATP binding site [chemical binding]; other site
485915007716	Walker B motif; other site
485915007717	arginine finger; other site
485915007718	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915007719	Archaeal ATPase; Region: Arch_ATPase; pfam01637
485915007720	AAA domain; Region: AAA_14; pfam13173
485915007721	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
485915007722	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
485915007723	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
485915007724	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
485915007725	non-specific DNA binding site [nucleotide binding]; other site
485915007726	salt bridge; other site
485915007727	sequence-specific DNA binding site [nucleotide binding]; other site
485915007728	4Fe-4S binding domain; Region: Fer4_6; pfam12837
485915007729	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
485915007730	Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143
485915007731	putative FMN binding site [chemical binding]; other site
485915007732	AAA domain; Region: AAA_14; pfam13173
485915007733	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
485915007734	PAS domain S-box; Region: sensory_box; TIGR00229
485915007735	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915007736	putative active site [active]
485915007737	heme pocket [chemical binding]; other site
485915007738	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915007739	PAS fold; Region: PAS_3; pfam08447
485915007740	putative active site [active]
485915007741	heme pocket [chemical binding]; other site
485915007742	PAS domain S-box; Region: sensory_box; TIGR00229
485915007743	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
485915007744	putative active site [active]
485915007745	heme pocket [chemical binding]; other site
485915007746	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
485915007747	GAF domain; Region: GAF; pfam01590
485915007748	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
485915007749	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915007750	dimer interface [polypeptide binding]; other site
485915007751	phosphorylation site [posttranslational modification]
485915007752	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915007753	ATP binding site [chemical binding]; other site
485915007754	Mg2+ binding site [ion binding]; other site
485915007755	G-X-G motif; other site
485915007756	Response regulator receiver domain; Region: Response_reg; pfam00072
485915007757	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915007758	active site
485915007759	phosphorylation site [posttranslational modification]
485915007760	intermolecular recognition site; other site
485915007761	dimerization interface [polypeptide binding]; other site
485915007762	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
485915007763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915007764	active site
485915007765	phosphorylation site [posttranslational modification]
485915007766	intermolecular recognition site; other site
485915007767	dimerization interface [polypeptide binding]; other site
485915007768	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
485915007769	Zn2+ binding site [ion binding]; other site
485915007770	Mg2+ binding site [ion binding]; other site
485915007771	Cache domain; Region: Cache_1; pfam02743
485915007772	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
485915007773	dimer interface [polypeptide binding]; other site
485915007774	putative CheW interface [polypeptide binding]; other site
485915007775	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
485915007776	ATP binding site [chemical binding]; other site
485915007777	activation loop (A-loop); other site
485915007778	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
485915007779	Ligand Binding Site [chemical binding]; other site
485915007780	BCCT family transporter; Region: BCCT; pfam02028
485915007781	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
485915007782	Ligand Binding Site [chemical binding]; other site
485915007783	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
485915007784	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
485915007785	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
485915007786	HlyD family secretion protein; Region: HlyD_3; pfam13437
485915007787	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
485915007788	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
485915007789	putative active site pocket [active]
485915007790	dimerization interface [polypeptide binding]; other site
485915007791	putative catalytic residue [active]
485915007792	Cupin domain; Region: Cupin_2; cl17218
485915007793	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
485915007794	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
485915007795	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
485915007796	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
485915007797	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
485915007798	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
485915007799	hybrid cluster protein; Provisional; Region: PRK05290
485915007800	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915007801	ACS interaction site; other site
485915007802	CODH interaction site; other site
485915007803	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
485915007804	hybrid metal cluster; other site
485915007805	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
485915007806	EamA-like transporter family; Region: EamA; pfam00892
485915007807	EamA-like transporter family; Region: EamA; pfam00892
485915007808	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
485915007809	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
485915007810	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
485915007811	Heavy-metal resistance; Region: Metal_resist; pfam13801
485915007812	dimer interface [polypeptide binding]; other site
485915007813	PAS domain; Region: PAS; smart00091
485915007814	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
485915007815	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
485915007816	dimer interface [polypeptide binding]; other site
485915007817	phosphorylation site [posttranslational modification]
485915007818	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915007819	ATP binding site [chemical binding]; other site
485915007820	G-X-G motif; other site
485915007821	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
485915007822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
485915007823	active site
485915007824	phosphorylation site [posttranslational modification]
485915007825	intermolecular recognition site; other site
485915007826	dimerization interface [polypeptide binding]; other site
485915007827	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915007828	Walker A motif; other site
485915007829	ATP binding site [chemical binding]; other site
485915007830	Walker B motif; other site
485915007831	arginine finger; other site
485915007832	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915007833	peroxiredoxin; Provisional; Region: PRK13189
485915007834	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
485915007835	dimer interface [polypeptide binding]; other site
485915007836	decamer (pentamer of dimers) interface [polypeptide binding]; other site
485915007837	catalytic triad [active]
485915007838	AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255
485915007839	putative nucleotide binding site [chemical binding]; other site
485915007840	putative substrate binding site [chemical binding]; other site
485915007841	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
485915007842	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
485915007843	Walker A/P-loop; other site
485915007844	ATP binding site [chemical binding]; other site
485915007845	Q-loop/lid; other site
485915007846	ABC transporter signature motif; other site
485915007847	Walker B; other site
485915007848	D-loop; other site
485915007849	H-loop/switch region; other site
485915007850	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915007851	dimer interface [polypeptide binding]; other site
485915007852	conserved gate region; other site
485915007853	ABC-ATPase subunit interface; other site
485915007854	PBP superfamily domain; Region: PBP_like_2; pfam12849
485915007855	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
485915007856	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
485915007857	Uncharacterized conserved protein [Function unknown]; Region: COG1656
485915007858	Protein of unknown function DUF82; Region: DUF82; pfam01927
485915007859	Peptidase family M48; Region: Peptidase_M48; pfam01435
485915007860	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
485915007861	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
485915007862	Part of AAA domain; Region: AAA_19; pfam13245
485915007863	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
485915007864	Family description; Region: UvrD_C_2; pfam13538
485915007865	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
485915007866	DHH family; Region: DHH; pfam01368
485915007867	DNA polymerase I; Provisional; Region: PRK05755
485915007868	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
485915007869	active site
485915007870	metal binding site 1 [ion binding]; metal-binding site
485915007871	putative 5' ssDNA interaction site; other site
485915007872	metal binding site 3; metal-binding site
485915007873	metal binding site 2 [ion binding]; metal-binding site
485915007874	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
485915007875	putative DNA binding site [nucleotide binding]; other site
485915007876	putative metal binding site [ion binding]; other site
485915007877	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
485915007878	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
485915007879	active site
485915007880	DNA binding site [nucleotide binding]
485915007881	catalytic site [active]
485915007882	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
485915007883	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
485915007884	catalytic residue [active]
485915007885	Domain of unknown function (DUF1844); Region: DUF1844; pfam08899
485915007886	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
485915007887	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
485915007888	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
485915007889	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
485915007890	acyl-activating enzyme (AAE) consensus motif; other site
485915007891	AMP binding site [chemical binding]; other site
485915007892	active site
485915007893	CoA binding site [chemical binding]; other site
485915007894	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
485915007895	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
485915007896	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
485915007897	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
485915007898	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
485915007899	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
485915007900	dimerization interface [polypeptide binding]; other site
485915007901	ATP binding site [chemical binding]; other site
485915007902	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
485915007903	dimerization interface [polypeptide binding]; other site
485915007904	ATP binding site [chemical binding]; other site
485915007905	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
485915007906	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
485915007907	substrate binding pocket [chemical binding]; other site
485915007908	chain length determination region; other site
485915007909	substrate-Mg2+ binding site; other site
485915007910	catalytic residues [active]
485915007911	aspartate-rich region 1; other site
485915007912	active site lid residues [active]
485915007913	aspartate-rich region 2; other site
485915007914	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
485915007915	futalosine nucleosidase; Region: fut_nucase; TIGR03664
485915007916	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
485915007917	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
485915007918	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
485915007919	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
485915007920	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
485915007921	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915007922	S-adenosylmethionine binding site [chemical binding]; other site
485915007923	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
485915007924	heme-binding residues [chemical binding]; other site
485915007925	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
485915007926	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
485915007927	inhibitor-cofactor binding pocket; inhibition site
485915007928	pyridoxal 5'-phosphate binding site [chemical binding]; other site
485915007929	catalytic residue [active]
485915007930	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
485915007931	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
485915007932	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
485915007933	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
485915007934	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
485915007935	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
485915007936	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
485915007937	Coenzyme A binding pocket [chemical binding]; other site
485915007938	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
485915007939	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
485915007940	putative active site [active]
485915007941	catalytic triad [active]
485915007942	putative dimer interface [polypeptide binding]; other site
485915007943	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
485915007944	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
485915007945	HlyD family secretion protein; Region: HlyD_3; pfam13437
485915007946	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
485915007947	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
485915007948	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
485915007949	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
485915007950	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
485915007951	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
485915007952	acyl-activating enzyme (AAE) consensus motif; other site
485915007953	AMP binding site [chemical binding]; other site
485915007954	active site
485915007955	CoA binding site [chemical binding]; other site
485915007956	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
485915007957	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
485915007958	transmembrane helices; other site
485915007959	FOG: CBS domain [General function prediction only]; Region: COG0517
485915007960	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
485915007961	FOG: CBS domain [General function prediction only]; Region: COG0517
485915007962	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
485915007963	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
485915007964	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
485915007965	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
485915007966	molybdopterin cofactor binding site; other site
485915007967	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
485915007968	molybdopterin cofactor binding site; other site
485915007969	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
485915007970	Predicted permeases [General function prediction only]; Region: COG0730
485915007971	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
485915007972	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
485915007973	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
485915007974	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
485915007975	metal binding site [ion binding]; metal-binding site
485915007976	active site
485915007977	I-site; other site
485915007978	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
485915007979	Membrane transport protein; Region: Mem_trans; cl09117
485915007980	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
485915007981	putative active site [active]
485915007982	PilZ domain; Region: PilZ; pfam07238
485915007983	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
485915007984	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915007985	Walker A motif; other site
485915007986	ATP binding site [chemical binding]; other site
485915007987	Walker B motif; other site
485915007988	arginine finger; other site
485915007989	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
485915007990	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
485915007991	Protein of unknown function (DUF770); Region: DUF770; cl01402
485915007992	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
485915007993	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
485915007994	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
485915007995	active site
485915007996	Riboflavin kinase; Region: Flavokinase; pfam01687
485915007997	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
485915007998	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
485915007999	Cl- selectivity filter; other site
485915008000	Cl- binding residues [ion binding]; other site
485915008001	pore gating glutamate residue; other site
485915008002	dimer interface [polypeptide binding]; other site
485915008003	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
485915008004	putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862
485915008005	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
485915008006	Cl- selectivity filter; other site
485915008007	Cl- binding residues [ion binding]; other site
485915008008	pore gating glutamate residue; other site
485915008009	dimer interface [polypeptide binding]; other site
485915008010	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
485915008011	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
485915008012	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
485915008013	putative active site; other site
485915008014	catalytic residue [active]
485915008015	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
485915008016	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
485915008017	S-adenosylmethionine binding site [chemical binding]; other site
485915008018	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
485915008019	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
485915008020	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
485915008021	DctM-like transporters; Region: DctM; pfam06808
485915008022	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
485915008023	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
485915008024	S4 RNA-binding domain; Region: S4; smart00363
485915008025	RNA binding surface [nucleotide binding]; other site
485915008026	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
485915008027	active site
485915008028	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
485915008029	AP (apurinic/apyrimidinic) site pocket; other site
485915008030	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
485915008031	DNA interaction; other site
485915008032	Metal-binding active site; metal-binding site
485915008033	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
485915008034	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
485915008035	active site
485915008036	adenylosuccinate lyase; Provisional; Region: PRK07492
485915008037	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
485915008038	tetramer interface [polypeptide binding]; other site
485915008039	active site
485915008040	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
485915008041	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
485915008042	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
485915008043	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
485915008044	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
485915008045	Ligand Binding Site [chemical binding]; other site
485915008046	Domain of unknown function DUF39; Region: DUF39; pfam01837
485915008047	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
485915008048	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
485915008049	Walker A motif; other site
485915008050	ATP binding site [chemical binding]; other site
485915008051	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
485915008052	DnaA box-binding interface [nucleotide binding]; other site
485915008053	DNA polymerase III subunit beta; Provisional; Region: PRK14947
485915008054	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
485915008055	putative DNA binding surface [nucleotide binding]; other site
485915008056	dimer interface [polypeptide binding]; other site
485915008057	beta-clamp/clamp loader binding surface; other site
485915008058	beta-clamp/translesion DNA polymerase binding surface; other site
485915008059	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
485915008060	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
485915008061	Mg2+ binding site [ion binding]; other site
485915008062	G-X-G motif; other site
485915008063	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
485915008064	anchoring element; other site
485915008065	dimer interface [polypeptide binding]; other site
485915008066	ATP binding site [chemical binding]; other site
485915008067	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
485915008068	active site
485915008069	putative metal-binding site [ion binding]; other site
485915008070	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
485915008071	DNA gyrase subunit A; Validated; Region: PRK05560
485915008072	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
485915008073	CAP-like domain; other site
485915008074	active site
485915008075	primary dimer interface [polypeptide binding]; other site
485915008076	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
485915008077	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
485915008078	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
485915008079	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
485915008080	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
485915008081	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
485915008082	ferredoxin; Provisional; Region: PRK08764
485915008083	Putative Fe-S cluster; Region: FeS; cl17515
485915008084	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
485915008085	GlpM protein; Region: GlpM; cl01212
485915008086	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
485915008087	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
485915008088	active site
485915008089	catalytic site [active]
485915008090	substrate binding site [chemical binding]; other site
485915008091	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
485915008092	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
485915008093	ligand binding site [chemical binding]; other site
485915008094	flexible hinge region; other site
485915008095	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
485915008096	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
485915008097	metal binding triad; other site
485915008098	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
485915008099	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
485915008100	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
485915008101	Na binding site [ion binding]; other site
485915008102	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
485915008103	acetyl-CoA synthetase; Provisional; Region: PRK00174
485915008104	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
485915008105	acyl-activating enzyme (AAE) consensus motif; other site
485915008106	AMP binding site [chemical binding]; other site
485915008107	active site
485915008108	CoA binding site [chemical binding]; other site
485915008109	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
485915008110	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
485915008111	intermolecular recognition site; other site
485915008112	active site
485915008113	dimerization interface [polypeptide binding]; other site
485915008114	LytTr DNA-binding domain; Region: LytTR; smart00850
485915008115	Predicted membrane protein [Function unknown]; Region: COG3671
485915008116	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
485915008117	active site residue [active]
485915008118	hypothetical protein; Provisional; Region: PRK11568
485915008119	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
485915008120	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
485915008121	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
485915008122	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
485915008123	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
485915008124	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
485915008125	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
485915008126	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
485915008127	putative active site [active]
485915008128	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
485915008129	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
485915008130	substrate binding pocket [chemical binding]; other site
485915008131	membrane-bound complex binding site; other site
485915008132	hinge residues; other site
485915008133	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
485915008134	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
485915008135	dimer interface [polypeptide binding]; other site
485915008136	conserved gate region; other site
485915008137	putative PBP binding loops; other site
485915008138	ABC-ATPase subunit interface; other site
485915008139	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
485915008140	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
485915008141	Walker A/P-loop; other site
485915008142	ATP binding site [chemical binding]; other site
485915008143	Q-loop/lid; other site
485915008144	ABC transporter signature motif; other site
485915008145	Walker B; other site
485915008146	D-loop; other site
485915008147	H-loop/switch region; other site
485915008148	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
485915008149	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
485915008150	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
485915008151	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
485915008152	active site
485915008153	dimer interface [polypeptide binding]; other site
485915008154	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
485915008155	dimer interface [polypeptide binding]; other site
485915008156	active site
485915008157	NAD-dependent deacetylase; Provisional; Region: PRK00481
485915008158	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
485915008159	NAD+ binding site [chemical binding]; other site
485915008160	substrate binding site [chemical binding]; other site
485915008161	Zn binding site [ion binding]; other site
485915008162	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
485915008163	Flavoprotein; Region: Flavoprotein; pfam02441
485915008164	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
485915008165	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
485915008166	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
485915008167	putative NAD(P) binding site [chemical binding]; other site
485915008168	active site
485915008169	putative substrate binding site [chemical binding]; other site
485915008170	ParG; Region: ParG; pfam09274
485915008171	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
485915008172	non-specific DNA binding site [nucleotide binding]; other site
485915008173	salt bridge; other site
485915008174	sequence-specific DNA binding site [nucleotide binding]; other site
485915008175	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
485915008176	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
485915008177	P-loop; other site
485915008178	Magnesium ion binding site [ion binding]; other site
485915008179	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
485915008180	Magnesium ion binding site [ion binding]; other site
485915008181	ParA-like protein; Provisional; Region: PHA02518
485915008182	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
485915008183	P-loop; other site
485915008184	Magnesium ion binding site [ion binding]; other site
485915008185	Staphylococcal nuclease homologues; Region: SNc; smart00318
485915008186	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
485915008187	Catalytic site; other site
485915008188	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
485915008189	Helix-turn-helix domain; Region: HTH_28; pfam13518
485915008190	putative transposase OrfB; Reviewed; Region: PHA02517
485915008191	HTH-like domain; Region: HTH_21; pfam13276
485915008192	Integrase core domain; Region: rve; pfam00665
485915008193	Integrase core domain; Region: rve_3; pfam13683
485915008194	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
485915008195	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
485915008196	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
485915008197	non-specific DNA binding site [nucleotide binding]; other site
485915008198	salt bridge; other site
485915008199	sequence-specific DNA binding site [nucleotide binding]; other site
485915008200	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
485915008201	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
485915008202	cofactor binding site; other site
485915008203	DNA binding site [nucleotide binding]
485915008204	substrate interaction site [chemical binding]; other site
485915008205	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
485915008206	non-specific DNA binding site [nucleotide binding]; other site
485915008207	salt bridge; other site
485915008208	sequence-specific DNA binding site [nucleotide binding]; other site
485915008209	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
485915008210	GIY-YIG motif/motif A; other site
485915008211	active site
485915008212	catalytic site [active]
485915008213	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
485915008214	active site
485915008215	catalytic residues [active]
485915008216	DNA binding site [nucleotide binding]
485915008217	Int/Topo IB signature motif; other site
485915008218	Helix-turn-helix domain; Region: HTH_28; pfam13518
485915008219	putative transposase OrfB; Reviewed; Region: PHA02517
485915008220	Homeodomain-like domain; Region: HTH_32; pfam13565
485915008221	Integrase core domain; Region: rve; pfam00665
485915008222	Integrase core domain; Region: rve_3; pfam13683
485915008223	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
485915008224	Protein of unknown function DUF262; Region: DUF262; pfam03235
485915008225	Protein of unknown function DUF262; Region: DUF262; pfam03235
485915008226	AAA-like domain; Region: AAA_10; pfam12846
485915008227	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
485915008228	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
485915008229	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
485915008230	active site
485915008231	metal binding site [ion binding]; metal-binding site
485915008232	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
485915008233	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203