-- dump date 20140619_063129 -- class Genbank::misc_feature -- table misc_feature_note -- id note 525897000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 525897000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 525897000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897000004 Walker A motif; other site 525897000005 ATP binding site [chemical binding]; other site 525897000006 Walker B motif; other site 525897000007 arginine finger; other site 525897000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 525897000009 DnaA box-binding interface [nucleotide binding]; other site 525897000010 PAS fold; Region: PAS_4; pfam08448 525897000011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897000012 putative active site [active] 525897000013 heme pocket [chemical binding]; other site 525897000014 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897000015 Zn2+ binding site [ion binding]; other site 525897000016 Mg2+ binding site [ion binding]; other site 525897000017 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 525897000018 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 525897000019 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525897000020 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897000021 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 525897000022 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 525897000023 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 525897000024 Walker A/P-loop; other site 525897000025 ATP binding site [chemical binding]; other site 525897000026 Q-loop/lid; other site 525897000027 ABC transporter signature motif; other site 525897000028 Walker B; other site 525897000029 D-loop; other site 525897000030 H-loop/switch region; other site 525897000031 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 525897000032 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 525897000033 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 525897000034 metal ion-dependent adhesion site (MIDAS); other site 525897000035 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 525897000036 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 525897000037 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 525897000038 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 525897000039 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 525897000040 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 525897000041 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 525897000042 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 525897000043 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 525897000044 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 525897000045 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 525897000046 G1 box; other site 525897000047 GTP/Mg2+ binding site [chemical binding]; other site 525897000048 Switch I region; other site 525897000049 G2 box; other site 525897000050 G3 box; other site 525897000051 Switch II region; other site 525897000052 G4 box; other site 525897000053 G5 box; other site 525897000054 Nucleoside recognition; Region: Gate; pfam07670 525897000055 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 525897000056 Nucleoside recognition; Region: Gate; pfam07670 525897000057 FeoA domain; Region: FeoA; pfam04023 525897000058 Uncharacterized conserved protein [Function unknown]; Region: COG1416 525897000059 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525897000060 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 525897000061 Ligand Binding Site [chemical binding]; other site 525897000062 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 525897000063 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 525897000064 Cl binding site [ion binding]; other site 525897000065 oligomer interface [polypeptide binding]; other site 525897000066 Response regulator receiver domain; Region: Response_reg; pfam00072 525897000067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897000068 active site 525897000069 phosphorylation site [posttranslational modification] 525897000070 intermolecular recognition site; other site 525897000071 dimerization interface [polypeptide binding]; other site 525897000072 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897000073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897000074 metal binding site [ion binding]; metal-binding site 525897000075 active site 525897000076 I-site; other site 525897000077 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 525897000078 CheB methylesterase; Region: CheB_methylest; pfam01339 525897000079 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 525897000080 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 525897000081 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 525897000082 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897000083 dimerization interface [polypeptide binding]; other site 525897000084 GAF domain; Region: GAF_2; pfam13185 525897000085 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 525897000086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897000087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897000088 dimer interface [polypeptide binding]; other site 525897000089 phosphorylation site [posttranslational modification] 525897000090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897000091 ATP binding site [chemical binding]; other site 525897000092 Mg2+ binding site [ion binding]; other site 525897000093 G-X-G motif; other site 525897000094 Response regulator receiver domain; Region: Response_reg; pfam00072 525897000095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897000096 active site 525897000097 phosphorylation site [posttranslational modification] 525897000098 intermolecular recognition site; other site 525897000099 dimerization interface [polypeptide binding]; other site 525897000100 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897000101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897000102 active site 525897000103 phosphorylation site [posttranslational modification] 525897000104 intermolecular recognition site; other site 525897000105 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897000106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897000107 active site 525897000108 phosphorylation site [posttranslational modification] 525897000109 intermolecular recognition site; other site 525897000110 dimerization interface [polypeptide binding]; other site 525897000111 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 525897000112 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 525897000113 Cl binding site [ion binding]; other site 525897000114 oligomer interface [polypeptide binding]; other site 525897000115 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 525897000116 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 525897000117 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 525897000118 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 525897000119 putative MPT binding site; other site 525897000120 Cache domain; Region: Cache_1; pfam02743 525897000121 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897000122 dimerization interface [polypeptide binding]; other site 525897000123 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525897000124 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897000125 dimer interface [polypeptide binding]; other site 525897000126 putative CheW interface [polypeptide binding]; other site 525897000127 Soluble P-type ATPase [General function prediction only]; Region: COG4087 525897000128 Protein of unknown function, DUF484; Region: DUF484; cl17449 525897000129 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897000130 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897000131 metal binding site [ion binding]; metal-binding site 525897000132 active site 525897000133 I-site; other site 525897000134 flavoprotein, HI0933 family; Region: TIGR00275 525897000135 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 525897000136 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525897000137 Ligand Binding Site [chemical binding]; other site 525897000138 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 525897000139 DctM-like transporters; Region: DctM; pfam06808 525897000140 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 525897000141 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 525897000142 hypothetical protein; Provisional; Region: PRK07338 525897000143 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 525897000144 metal binding site [ion binding]; metal-binding site 525897000145 dimer interface [polypeptide binding]; other site 525897000146 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 525897000147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897000148 FeS/SAM binding site; other site 525897000149 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525897000150 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897000151 PAS fold; Region: PAS_3; pfam08447 525897000152 putative active site [active] 525897000153 heme pocket [chemical binding]; other site 525897000154 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525897000155 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525897000156 DNA binding residues [nucleotide binding] 525897000157 dimerization interface [polypeptide binding]; other site 525897000158 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 525897000159 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 525897000160 active site 525897000161 multimer interface [polypeptide binding]; other site 525897000162 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 525897000163 predicted active site [active] 525897000164 catalytic triad [active] 525897000165 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897000166 dimer interface [polypeptide binding]; other site 525897000167 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 525897000168 putative CheW interface [polypeptide binding]; other site 525897000169 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 525897000170 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 525897000171 active site 525897000172 putative substrate binding pocket [chemical binding]; other site 525897000173 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 525897000174 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 525897000175 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897000176 FeS/SAM binding site; other site 525897000177 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 525897000178 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 525897000179 dimerization interface [polypeptide binding]; other site 525897000180 putative ATP binding site [chemical binding]; other site 525897000181 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897000182 Radical SAM superfamily; Region: Radical_SAM; pfam04055 525897000183 FeS/SAM binding site; other site 525897000184 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 525897000185 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 525897000186 23S rRNA interface [nucleotide binding]; other site 525897000187 L3 interface [polypeptide binding]; other site 525897000188 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 525897000189 HD domain; Region: HD_3; pfam13023 525897000190 CBS domain; Region: CBS; pfam00571 525897000191 FOG: CBS domain [General function prediction only]; Region: COG0517 525897000192 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525897000193 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525897000194 substrate binding pocket [chemical binding]; other site 525897000195 membrane-bound complex binding site; other site 525897000196 hinge residues; other site 525897000197 PAS domain S-box; Region: sensory_box; TIGR00229 525897000198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897000199 putative active site [active] 525897000200 heme pocket [chemical binding]; other site 525897000201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897000202 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897000203 putative active site [active] 525897000204 heme pocket [chemical binding]; other site 525897000205 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897000206 putative active site [active] 525897000207 heme pocket [chemical binding]; other site 525897000208 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897000209 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897000210 putative active site [active] 525897000211 heme pocket [chemical binding]; other site 525897000212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897000213 ATP binding site [chemical binding]; other site 525897000214 Mg2+ binding site [ion binding]; other site 525897000215 G-X-G motif; other site 525897000216 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 525897000217 Found in ATP-dependent protease La (LON); Region: LON; smart00464 525897000218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897000219 Walker A motif; other site 525897000220 ATP binding site [chemical binding]; other site 525897000221 Walker B motif; other site 525897000222 arginine finger; other site 525897000223 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 525897000224 hypothetical protein; Reviewed; Region: PRK00024 525897000225 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 525897000226 MPN+ (JAMM) motif; other site 525897000227 Zinc-binding site [ion binding]; other site 525897000228 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 525897000229 Lipopolysaccharide-assembly; Region: LptE; cl01125 525897000230 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 525897000231 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 525897000232 HIGH motif; other site 525897000233 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 525897000234 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 525897000235 active site 525897000236 KMSKS motif; other site 525897000237 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 525897000238 tRNA binding surface [nucleotide binding]; other site 525897000239 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 525897000240 putative RNA binding site [nucleotide binding]; other site 525897000241 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 525897000242 homopentamer interface [polypeptide binding]; other site 525897000243 active site 525897000244 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 525897000245 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 525897000246 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 525897000247 dimerization interface [polypeptide binding]; other site 525897000248 active site 525897000249 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 525897000250 Lumazine binding domain; Region: Lum_binding; pfam00677 525897000251 Lumazine binding domain; Region: Lum_binding; pfam00677 525897000252 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 525897000253 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 525897000254 catalytic motif [active] 525897000255 Zn binding site [ion binding]; other site 525897000256 RibD C-terminal domain; Region: RibD_C; cl17279 525897000257 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 525897000258 catalytic motif [active] 525897000259 Zn binding site [ion binding]; other site 525897000260 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 525897000261 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 525897000262 dimer interface [polypeptide binding]; other site 525897000263 active site 525897000264 glycine-pyridoxal phosphate binding site [chemical binding]; other site 525897000265 folate binding site [chemical binding]; other site 525897000266 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 525897000267 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 525897000268 dimer interface [polypeptide binding]; other site 525897000269 active site 525897000270 acyl carrier protein; Provisional; Region: acpP; PRK00982 525897000271 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 525897000272 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 525897000273 NAD(P) binding site [chemical binding]; other site 525897000274 homotetramer interface [polypeptide binding]; other site 525897000275 homodimer interface [polypeptide binding]; other site 525897000276 active site 525897000277 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 525897000278 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 525897000279 dimer interface [polypeptide binding]; other site 525897000280 active site 525897000281 CoA binding pocket [chemical binding]; other site 525897000282 putative phosphate acyltransferase; Provisional; Region: PRK05331 525897000283 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 525897000284 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 525897000285 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 525897000286 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 525897000287 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 525897000288 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 525897000289 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 525897000290 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 525897000291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 525897000292 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 525897000293 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 525897000294 HIGH motif; other site 525897000295 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 525897000296 active site 525897000297 KMSKS motif; other site 525897000298 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 525897000299 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 525897000300 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 525897000301 catalytic residues [active] 525897000302 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 525897000303 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 525897000304 inhibitor-cofactor binding pocket; inhibition site 525897000305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897000306 catalytic residue [active] 525897000307 Predicted permeases [General function prediction only]; Region: RarD; COG2962 525897000308 Transglycosylase; Region: Transgly; cl17702 525897000309 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 525897000310 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 525897000311 putative FMN binding site [chemical binding]; other site 525897000312 fumarate hydratase; Reviewed; Region: fumC; PRK00485 525897000313 Class II fumarases; Region: Fumarase_classII; cd01362 525897000314 active site 525897000315 tetramer interface [polypeptide binding]; other site 525897000316 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 525897000317 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 525897000318 putative metal binding site; other site 525897000319 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 525897000320 thymidylate kinase; Validated; Region: tmk; PRK00698 525897000321 TMP-binding site; other site 525897000322 ATP-binding site [chemical binding]; other site 525897000323 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 525897000324 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 525897000325 generic binding surface I; other site 525897000326 generic binding surface II; other site 525897000327 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 525897000328 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897000329 Zn2+ binding site [ion binding]; other site 525897000330 Mg2+ binding site [ion binding]; other site 525897000331 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 525897000332 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897000333 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 525897000334 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 525897000335 dimer interface [polypeptide binding]; other site 525897000336 PYR/PP interface [polypeptide binding]; other site 525897000337 TPP binding site [chemical binding]; other site 525897000338 substrate binding site [chemical binding]; other site 525897000339 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 525897000340 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 525897000341 TPP-binding site [chemical binding]; other site 525897000342 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 525897000343 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 525897000344 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 525897000345 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 525897000346 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 525897000347 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 525897000348 intersubunit interface [polypeptide binding]; other site 525897000349 active site 525897000350 zinc binding site [ion binding]; other site 525897000351 Na+ binding site [ion binding]; other site 525897000352 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 525897000353 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 525897000354 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 525897000355 Divergent AAA domain; Region: AAA_4; pfam04326 525897000356 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 525897000357 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 525897000358 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 525897000359 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 525897000360 active site 525897000361 PHP Thumb interface [polypeptide binding]; other site 525897000362 metal binding site [ion binding]; metal-binding site 525897000363 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 525897000364 generic binding surface I; other site 525897000365 generic binding surface II; other site 525897000366 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 525897000367 active site 525897000368 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 525897000369 putative active site [active] 525897000370 dimerization interface [polypeptide binding]; other site 525897000371 putative tRNAtyr binding site [nucleotide binding]; other site 525897000372 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 525897000373 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 525897000374 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 525897000375 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 525897000376 putative active site [active] 525897000377 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 525897000378 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 525897000379 Protein export membrane protein; Region: SecD_SecF; cl14618 525897000380 Protein export membrane protein; Region: SecD_SecF; cl14618 525897000381 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 525897000382 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525897000383 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897000384 division inhibitor protein; Provisional; Region: slmA; PRK09480 525897000385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525897000386 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 525897000387 nudix motif; other site 525897000388 glycogen synthase; Provisional; Region: glgA; PRK00654 525897000389 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 525897000390 ADP-binding pocket [chemical binding]; other site 525897000391 homodimer interface [polypeptide binding]; other site 525897000392 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 525897000393 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525897000394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525897000395 non-specific DNA binding site [nucleotide binding]; other site 525897000396 salt bridge; other site 525897000397 sequence-specific DNA binding site [nucleotide binding]; other site 525897000398 Cupin domain; Region: Cupin_2; pfam07883 525897000399 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525897000400 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 525897000401 acyl-activating enzyme (AAE) consensus motif; other site 525897000402 AMP binding site [chemical binding]; other site 525897000403 active site 525897000404 CoA binding site [chemical binding]; other site 525897000405 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525897000406 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897000407 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 525897000408 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 525897000409 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525897000410 active site 525897000411 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 525897000412 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 525897000413 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 525897000414 Probable Catalytic site; other site 525897000415 metal-binding site 525897000416 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525897000417 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 525897000418 active site 525897000419 metal-binding site 525897000420 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 525897000421 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 525897000422 active site 525897000423 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897000424 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 525897000425 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 525897000426 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525897000427 active site 525897000428 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 525897000429 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525897000430 active site 525897000431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897000432 Radical SAM superfamily; Region: Radical_SAM; pfam04055 525897000433 FeS/SAM binding site; other site 525897000434 Trm112p-like protein; Region: Trm112p; pfam03966 525897000435 Methyltransferase domain; Region: Methyltransf_31; pfam13847 525897000436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897000437 S-adenosylmethionine binding site [chemical binding]; other site 525897000438 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 525897000439 Methyltransferase domain; Region: Methyltransf_24; pfam13578 525897000440 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 525897000441 active site 525897000442 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 525897000443 dimer interface [polypeptide binding]; other site 525897000444 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 525897000445 Ligand Binding Site [chemical binding]; other site 525897000446 Molecular Tunnel; other site 525897000447 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 525897000448 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897000449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897000450 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 525897000451 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 525897000452 Probable Catalytic site; other site 525897000453 metal-binding site 525897000454 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 525897000455 putative ligand binding site [chemical binding]; other site 525897000456 putative catalytic site [active] 525897000457 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 525897000458 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 525897000459 NAD binding site [chemical binding]; other site 525897000460 putative substrate binding site 2 [chemical binding]; other site 525897000461 putative substrate binding site 1 [chemical binding]; other site 525897000462 active site 525897000463 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 525897000464 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 525897000465 active site 525897000466 NTP binding site [chemical binding]; other site 525897000467 metal binding triad [ion binding]; metal-binding site 525897000468 antibiotic binding site [chemical binding]; other site 525897000469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897000470 binding surface 525897000471 TPR motif; other site 525897000472 TPR repeat; Region: TPR_11; pfam13414 525897000473 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 525897000474 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 525897000475 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 525897000476 catalytic site [active] 525897000477 subunit interface [polypeptide binding]; other site 525897000478 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 525897000479 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 525897000480 Ligand binding site; other site 525897000481 oligomer interface; other site 525897000482 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 525897000483 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 525897000484 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 525897000485 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 525897000486 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525897000487 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 525897000488 HupF/HypC family; Region: HupF_HypC; pfam01455 525897000489 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 525897000490 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 525897000491 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 525897000492 dimerization interface [polypeptide binding]; other site 525897000493 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 525897000494 ATP binding site [chemical binding]; other site 525897000495 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 525897000496 active site 525897000497 catalytic site [active] 525897000498 substrate binding site [chemical binding]; other site 525897000499 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 525897000500 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 525897000501 DHHA2 domain; Region: DHHA2; pfam02833 525897000502 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 525897000503 active site 525897000504 phosphorylation site [posttranslational modification] 525897000505 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 525897000506 active pocket/dimerization site; other site 525897000507 active site 525897000508 phosphorylation site [posttranslational modification] 525897000509 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 525897000510 AAA domain; Region: AAA_18; pfam13238 525897000511 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 525897000512 active site 525897000513 phosphorylation site [posttranslational modification] 525897000514 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 525897000515 30S subunit binding site; other site 525897000516 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 525897000517 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 525897000518 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 525897000519 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 525897000520 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 525897000521 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 525897000522 Walker A/P-loop; other site 525897000523 ATP binding site [chemical binding]; other site 525897000524 Q-loop/lid; other site 525897000525 ABC transporter signature motif; other site 525897000526 Walker B; other site 525897000527 D-loop; other site 525897000528 H-loop/switch region; other site 525897000529 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 525897000530 OstA-like protein; Region: OstA; pfam03968 525897000531 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 525897000532 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 525897000533 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 525897000534 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 525897000535 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 525897000536 CTP synthetase; Validated; Region: pyrG; PRK05380 525897000537 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 525897000538 Catalytic site [active] 525897000539 active site 525897000540 UTP binding site [chemical binding]; other site 525897000541 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 525897000542 active site 525897000543 putative oxyanion hole; other site 525897000544 catalytic triad [active] 525897000545 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 525897000546 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 525897000547 conserved cys residue [active] 525897000548 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 525897000549 nucleoside/Zn binding site; other site 525897000550 dimer interface [polypeptide binding]; other site 525897000551 catalytic motif [active] 525897000552 HipA N-terminal domain; Region: Couple_hipA; pfam13657 525897000553 HipA-like N-terminal domain; Region: HipA_N; pfam07805 525897000554 HipA-like C-terminal domain; Region: HipA_C; pfam07804 525897000555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525897000556 sequence-specific DNA binding site [nucleotide binding]; other site 525897000557 salt bridge; other site 525897000558 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 525897000559 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 525897000560 non-heme iron binding site [ion binding]; other site 525897000561 dimer interface [polypeptide binding]; other site 525897000562 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 525897000563 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 525897000564 ligand binding site [chemical binding]; other site 525897000565 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 525897000566 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 525897000567 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 525897000568 putative dimer interface [polypeptide binding]; other site 525897000569 [2Fe-2S] cluster binding site [ion binding]; other site 525897000570 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 525897000571 dimer interface [polypeptide binding]; other site 525897000572 [2Fe-2S] cluster binding site [ion binding]; other site 525897000573 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 525897000574 SLBB domain; Region: SLBB; pfam10531 525897000575 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 525897000576 4Fe-4S binding domain; Region: Fer4; cl02805 525897000577 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897000578 4Fe-4S binding domain; Region: Fer4; pfam00037 525897000579 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 525897000580 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 525897000581 catalytic loop [active] 525897000582 iron binding site [ion binding]; other site 525897000583 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 525897000584 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897000585 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 525897000586 [4Fe-4S] binding site [ion binding]; other site 525897000587 molybdopterin cofactor binding site; other site 525897000588 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 525897000589 molybdopterin cofactor binding site; other site 525897000590 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 525897000591 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 525897000592 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 525897000593 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 525897000594 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 525897000595 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 525897000596 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525897000597 molybdopterin cofactor binding site; other site 525897000598 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 525897000599 molybdopterin cofactor binding site; other site 525897000600 PilZ domain; Region: PilZ; pfam07238 525897000601 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 525897000602 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 525897000603 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 525897000604 active site 525897000605 DNA binding site [nucleotide binding] 525897000606 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 525897000607 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 525897000608 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 525897000609 Catalytic site [active] 525897000610 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 525897000611 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525897000612 molybdopterin cofactor binding site; other site 525897000613 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 525897000614 molybdopterin cofactor binding site; other site 525897000615 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525897000616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897000617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897000618 dimer interface [polypeptide binding]; other site 525897000619 phosphorylation site [posttranslational modification] 525897000620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897000621 ATP binding site [chemical binding]; other site 525897000622 Mg2+ binding site [ion binding]; other site 525897000623 G-X-G motif; other site 525897000624 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897000625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897000626 active site 525897000627 phosphorylation site [posttranslational modification] 525897000628 intermolecular recognition site; other site 525897000629 dimerization interface [polypeptide binding]; other site 525897000630 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525897000631 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897000632 PAS fold; Region: PAS_3; pfam08447 525897000633 putative active site [active] 525897000634 heme pocket [chemical binding]; other site 525897000635 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 525897000636 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 525897000637 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897000638 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897000639 dimer interface [polypeptide binding]; other site 525897000640 phosphorylation site [posttranslational modification] 525897000641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897000642 ATP binding site [chemical binding]; other site 525897000643 Mg2+ binding site [ion binding]; other site 525897000644 G-X-G motif; other site 525897000645 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897000646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897000647 active site 525897000648 phosphorylation site [posttranslational modification] 525897000649 intermolecular recognition site; other site 525897000650 dimerization interface [polypeptide binding]; other site 525897000651 Divergent AAA domain; Region: AAA_4; pfam04326 525897000652 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 525897000653 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 525897000654 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 525897000655 homodimer interface [polypeptide binding]; other site 525897000656 substrate-cofactor binding pocket; other site 525897000657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897000658 catalytic residue [active] 525897000659 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 525897000660 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 525897000661 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 525897000662 EamA-like transporter family; Region: EamA; pfam00892 525897000663 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 525897000664 EamA-like transporter family; Region: EamA; pfam00892 525897000665 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 525897000666 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 525897000667 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 525897000668 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 525897000669 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 525897000670 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 525897000671 dimer interface [polypeptide binding]; other site 525897000672 PYR/PP interface [polypeptide binding]; other site 525897000673 TPP binding site [chemical binding]; other site 525897000674 substrate binding site [chemical binding]; other site 525897000675 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 525897000676 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 525897000677 TPP-binding site [chemical binding]; other site 525897000678 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 525897000679 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 525897000680 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 525897000681 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 525897000682 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 525897000683 GTP-binding protein Der; Reviewed; Region: PRK00093 525897000684 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 525897000685 G1 box; other site 525897000686 GTP/Mg2+ binding site [chemical binding]; other site 525897000687 Switch I region; other site 525897000688 G2 box; other site 525897000689 Switch II region; other site 525897000690 G3 box; other site 525897000691 G4 box; other site 525897000692 G5 box; other site 525897000693 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 525897000694 G1 box; other site 525897000695 GTP/Mg2+ binding site [chemical binding]; other site 525897000696 Switch I region; other site 525897000697 G2 box; other site 525897000698 G3 box; other site 525897000699 Switch II region; other site 525897000700 G4 box; other site 525897000701 G5 box; other site 525897000702 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 525897000703 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 525897000704 homodimer interface [polypeptide binding]; other site 525897000705 substrate-cofactor binding pocket; other site 525897000706 catalytic residue [active] 525897000707 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 525897000708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897000709 Walker A motif; other site 525897000710 ATP binding site [chemical binding]; other site 525897000711 Walker B motif; other site 525897000712 arginine finger; other site 525897000713 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 525897000714 hypothetical protein; Validated; Region: PRK00153 525897000715 recombination protein RecR; Reviewed; Region: recR; PRK00076 525897000716 RecR protein; Region: RecR; pfam02132 525897000717 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 525897000718 putative active site [active] 525897000719 putative metal-binding site [ion binding]; other site 525897000720 tetramer interface [polypeptide binding]; other site 525897000721 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 525897000722 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 525897000723 DNA binding site [nucleotide binding] 525897000724 AAA domain; Region: AAA_30; pfam13604 525897000725 Family description; Region: UvrD_C_2; pfam13538 525897000726 trigger factor; Region: tig; TIGR00115 525897000727 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 525897000728 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 525897000729 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 525897000730 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 525897000731 oligomer interface [polypeptide binding]; other site 525897000732 active site residues [active] 525897000733 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 525897000734 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 525897000735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897000736 Walker A motif; other site 525897000737 ATP binding site [chemical binding]; other site 525897000738 Walker B motif; other site 525897000739 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 525897000740 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 525897000741 Found in ATP-dependent protease La (LON); Region: LON; smart00464 525897000742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897000743 Walker A motif; other site 525897000744 ATP binding site [chemical binding]; other site 525897000745 Walker B motif; other site 525897000746 arginine finger; other site 525897000747 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 525897000748 Predicted membrane protein [Function unknown]; Region: COG1238 525897000749 Uncharacterized conserved protein [Function unknown]; Region: COG1359 525897000750 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897000751 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897000752 metal binding site [ion binding]; metal-binding site 525897000753 active site 525897000754 I-site; other site 525897000755 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897000756 Zn2+ binding site [ion binding]; other site 525897000757 Mg2+ binding site [ion binding]; other site 525897000758 Uncharacterized conserved protein [Function unknown]; Region: COG1284 525897000759 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 525897000760 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 525897000761 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 525897000762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525897000763 Coenzyme A binding pocket [chemical binding]; other site 525897000764 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 525897000765 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897000766 FeS/SAM binding site; other site 525897000767 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 525897000768 phosphoenolpyruvate synthase; Validated; Region: PRK06464 525897000769 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 525897000770 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 525897000771 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 525897000772 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 525897000773 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 525897000774 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 525897000775 PhoU domain; Region: PhoU; pfam01895 525897000776 PhoU domain; Region: PhoU; pfam01895 525897000777 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897000778 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897000779 dimerization interface [polypeptide binding]; other site 525897000780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897000781 ATP binding site [chemical binding]; other site 525897000782 Mg2+ binding site [ion binding]; other site 525897000783 G-X-G motif; other site 525897000784 Response regulator receiver domain; Region: Response_reg; pfam00072 525897000785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897000786 active site 525897000787 phosphorylation site [posttranslational modification] 525897000788 intermolecular recognition site; other site 525897000789 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 525897000790 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897000791 Zn2+ binding site [ion binding]; other site 525897000792 Mg2+ binding site [ion binding]; other site 525897000793 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 525897000794 Nuclease-related domain; Region: NERD; pfam08378 525897000795 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 525897000796 Transposase; Region: HTH_Tnp_1; pfam01527 525897000797 putative transposase OrfB; Reviewed; Region: PHA02517 525897000798 HTH-like domain; Region: HTH_21; pfam13276 525897000799 Integrase core domain; Region: rve; pfam00665 525897000800 Integrase core domain; Region: rve_3; pfam13683 525897000801 Transposase; Region: DEDD_Tnp_IS110; pfam01548 525897000802 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 525897000803 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 525897000804 Transcriptional regulator [Transcription]; Region: LysR; COG0583 525897000805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 525897000806 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 525897000807 dimerization interface [polypeptide binding]; other site 525897000808 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 525897000809 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 525897000810 intracellular protease, PfpI family; Region: PfpI; TIGR01382 525897000811 proposed catalytic triad [active] 525897000812 conserved cys residue [active] 525897000813 HipA N-terminal domain; Region: Couple_hipA; cl11853 525897000814 HipA-like N-terminal domain; Region: HipA_N; pfam07805 525897000815 HipA-like C-terminal domain; Region: HipA_C; pfam07804 525897000816 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525897000817 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525897000818 non-specific DNA binding site [nucleotide binding]; other site 525897000819 salt bridge; other site 525897000820 sequence-specific DNA binding site [nucleotide binding]; other site 525897000821 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 525897000822 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 525897000823 putative active site [active] 525897000824 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897000825 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 525897000826 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897000827 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 525897000828 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 525897000829 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 525897000830 active site 525897000831 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 525897000832 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 525897000833 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 525897000834 MoaE homodimer interface [polypeptide binding]; other site 525897000835 active site residues [active] 525897000836 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 525897000837 YcaO-like family; Region: YcaO; pfam02624 525897000838 Tetratricopeptide repeat; Region: TPR_16; pfam13432 525897000839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897000840 binding surface 525897000841 TPR motif; other site 525897000842 TPR repeat; Region: TPR_11; pfam13414 525897000843 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 525897000844 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 525897000845 Domain of unknown function (DUF814); Region: DUF814; pfam05670 525897000846 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 525897000847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897000848 FeS/SAM binding site; other site 525897000849 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 525897000850 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 525897000851 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 525897000852 PhoH-like protein; Region: PhoH; pfam02562 525897000853 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 525897000854 YcaO-like family; Region: YcaO; pfam02624 525897000855 ornithine carbamoyltransferase; Provisional; Region: PRK00779 525897000856 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 525897000857 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 525897000858 argininosuccinate synthase; Provisional; Region: PRK13820 525897000859 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 525897000860 ANP binding site [chemical binding]; other site 525897000861 Substrate Binding Site II [chemical binding]; other site 525897000862 Substrate Binding Site I [chemical binding]; other site 525897000863 argininosuccinate lyase; Provisional; Region: PRK00855 525897000864 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 525897000865 active sites [active] 525897000866 tetramer interface [polypeptide binding]; other site 525897000867 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 525897000868 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 525897000869 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897000870 dimerization interface [polypeptide binding]; other site 525897000871 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897000872 dimer interface [polypeptide binding]; other site 525897000873 putative CheW interface [polypeptide binding]; other site 525897000874 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 525897000875 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 525897000876 zinc binding site [ion binding]; other site 525897000877 putative ligand binding site [chemical binding]; other site 525897000878 chlorohydrolase; Provisional; Region: PRK08418 525897000879 Amidohydrolase; Region: Amidohydro_5; pfam13594 525897000880 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 525897000881 active site 525897000882 FtsH Extracellular; Region: FtsH_ext; pfam06480 525897000883 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 525897000884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897000885 Walker A motif; other site 525897000886 ATP binding site [chemical binding]; other site 525897000887 Walker B motif; other site 525897000888 arginine finger; other site 525897000889 Peptidase family M41; Region: Peptidase_M41; pfam01434 525897000890 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 525897000891 dihydropteroate synthase; Region: DHPS; TIGR01496 525897000892 substrate binding pocket [chemical binding]; other site 525897000893 dimer interface [polypeptide binding]; other site 525897000894 inhibitor binding site; inhibition site 525897000895 Uncharacterized conserved protein [Function unknown]; Region: COG1624 525897000896 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 525897000897 YbbR-like protein; Region: YbbR; pfam07949 525897000898 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 525897000899 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 525897000900 active site 525897000901 substrate binding site [chemical binding]; other site 525897000902 metal binding site [ion binding]; metal-binding site 525897000903 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 525897000904 active site 525897000905 tetramer interface; other site 525897000906 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 525897000907 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525897000908 ATP binding site [chemical binding]; other site 525897000909 putative Mg++ binding site [ion binding]; other site 525897000910 helicase superfamily c-terminal domain; Region: HELICc; smart00490 525897000911 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 525897000912 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 525897000913 putative dimer interface [polypeptide binding]; other site 525897000914 putative anticodon binding site; other site 525897000915 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 525897000916 homodimer interface [polypeptide binding]; other site 525897000917 motif 1; other site 525897000918 motif 2; other site 525897000919 active site 525897000920 motif 3; other site 525897000921 Protein of unknown function (DUF456); Region: DUF456; pfam04306 525897000922 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 525897000923 RNA/DNA hybrid binding site [nucleotide binding]; other site 525897000924 active site 525897000925 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 525897000926 HflK protein; Region: hflK; TIGR01933 525897000927 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 525897000928 HflC protein; Region: hflC; TIGR01932 525897000929 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 525897000930 AIR carboxylase; Region: AIRC; pfam00731 525897000931 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 525897000932 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 525897000933 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 525897000934 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 525897000935 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 525897000936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897000937 ATP binding site [chemical binding]; other site 525897000938 Mg2+ binding site [ion binding]; other site 525897000939 G-X-G motif; other site 525897000940 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 525897000941 ATP binding site [chemical binding]; other site 525897000942 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 525897000943 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 525897000944 Organic solvent tolerance protein; Region: OstA_C; pfam04453 525897000945 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 525897000946 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 525897000947 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 525897000948 Cysteine-rich domain; Region: CCG; pfam02754 525897000949 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 525897000950 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 525897000951 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 525897000952 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 525897000953 Flagellin N-methylase; Region: FliB; cl00497 525897000954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897000955 binding surface 525897000956 TPR motif; other site 525897000957 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525897000958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897000959 binding surface 525897000960 TPR motif; other site 525897000961 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525897000962 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 525897000963 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 525897000964 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 525897000965 Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679 525897000966 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 525897000967 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 525897000968 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 525897000969 catalytic triad [active] 525897000970 Flagellin N-methylase; Region: FliB; cl00497 525897000971 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 525897000972 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 525897000973 HSP70 interaction site [polypeptide binding]; other site 525897000974 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 525897000975 substrate binding site [polypeptide binding]; other site 525897000976 dimer interface [polypeptide binding]; other site 525897000977 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 525897000978 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 525897000979 Clp amino terminal domain; Region: Clp_N; pfam02861 525897000980 Clp amino terminal domain; Region: Clp_N; pfam02861 525897000981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897000982 Walker A motif; other site 525897000983 ATP binding site [chemical binding]; other site 525897000984 Walker B motif; other site 525897000985 arginine finger; other site 525897000986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897000987 Walker A motif; other site 525897000988 ATP binding site [chemical binding]; other site 525897000989 Walker B motif; other site 525897000990 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 525897000991 Putative pyruvate format-lyase activating enzyme (DUF1786); Region: DUF1786; cl01638 525897000992 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 525897000993 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 525897000994 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 525897000995 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 525897000996 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 525897000997 RNA binding site [nucleotide binding]; other site 525897000998 EamA-like transporter family; Region: EamA; pfam00892 525897000999 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 525897001000 EamA-like transporter family; Region: EamA; pfam00892 525897001001 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 525897001002 Ferritin-like domain; Region: Ferritin; pfam00210 525897001003 heme binding site [chemical binding]; other site 525897001004 ferroxidase pore; other site 525897001005 ferroxidase diiron center [ion binding]; other site 525897001006 Protein of unknown function DUF89; Region: DUF89; cl15397 525897001007 MltA specific insert domain; Region: MltA; smart00925 525897001008 3D domain; Region: 3D; pfam06725 525897001009 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 525897001010 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 525897001011 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 525897001012 GatB domain; Region: GatB_Yqey; smart00845 525897001013 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 525897001014 peptidase T-like protein; Region: PepT-like; TIGR01883 525897001015 metal binding site [ion binding]; metal-binding site 525897001016 putative dimer interface [polypeptide binding]; other site 525897001017 TM2 domain; Region: TM2; cl00984 525897001018 TM2 domain; Region: TM2; cl00984 525897001019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525897001020 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525897001021 substrate binding pocket [chemical binding]; other site 525897001022 membrane-bound complex binding site; other site 525897001023 hinge residues; other site 525897001024 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 525897001025 active site clefts [active] 525897001026 zinc binding site [ion binding]; other site 525897001027 dimer interface [polypeptide binding]; other site 525897001028 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 525897001029 Tim44-like domain; Region: Tim44; cl09208 525897001030 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 525897001031 oligomeric interface; other site 525897001032 putative active site [active] 525897001033 homodimer interface [polypeptide binding]; other site 525897001034 thioredoxin 2; Provisional; Region: PRK10996 525897001035 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 525897001036 catalytic residues [active] 525897001037 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 525897001038 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 525897001039 NAD binding site [chemical binding]; other site 525897001040 homotetramer interface [polypeptide binding]; other site 525897001041 homodimer interface [polypeptide binding]; other site 525897001042 substrate binding site [chemical binding]; other site 525897001043 active site 525897001044 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 525897001045 ATP binding site [chemical binding]; other site 525897001046 active site 525897001047 substrate binding site [chemical binding]; other site 525897001048 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 525897001049 histidinol dehydrogenase; Region: hisD; TIGR00069 525897001050 NAD binding site [chemical binding]; other site 525897001051 dimerization interface [polypeptide binding]; other site 525897001052 product binding site; other site 525897001053 substrate binding site [chemical binding]; other site 525897001054 zinc binding site [ion binding]; other site 525897001055 catalytic residues [active] 525897001056 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 525897001057 Family description; Region: VCBS; pfam13517 525897001058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897001059 Tetratricopeptide repeat; Region: TPR_16; pfam13432 525897001060 TPR motif; other site 525897001061 Response regulator receiver domain; Region: Response_reg; pfam00072 525897001062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001063 active site 525897001064 phosphorylation site [posttranslational modification] 525897001065 intermolecular recognition site; other site 525897001066 dimerization interface [polypeptide binding]; other site 525897001067 Response regulator receiver domain; Region: Response_reg; pfam00072 525897001068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001069 active site 525897001070 phosphorylation site [posttranslational modification] 525897001071 intermolecular recognition site; other site 525897001072 dimerization interface [polypeptide binding]; other site 525897001073 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525897001074 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 525897001075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897001076 putative active site [active] 525897001077 heme pocket [chemical binding]; other site 525897001078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897001079 dimer interface [polypeptide binding]; other site 525897001080 phosphorylation site [posttranslational modification] 525897001081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897001082 ATP binding site [chemical binding]; other site 525897001083 Mg2+ binding site [ion binding]; other site 525897001084 G-X-G motif; other site 525897001085 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897001086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001087 active site 525897001088 phosphorylation site [posttranslational modification] 525897001089 intermolecular recognition site; other site 525897001090 dimerization interface [polypeptide binding]; other site 525897001091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897001092 Walker A motif; other site 525897001093 ATP binding site [chemical binding]; other site 525897001094 Walker B motif; other site 525897001095 arginine finger; other site 525897001096 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897001097 HEAT repeats; Region: HEAT_2; pfam13646 525897001098 HEAT repeats; Region: HEAT_2; pfam13646 525897001099 Response regulator receiver domain; Region: Response_reg; pfam00072 525897001100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001101 active site 525897001102 phosphorylation site [posttranslational modification] 525897001103 intermolecular recognition site; other site 525897001104 dimerization interface [polypeptide binding]; other site 525897001105 purine nucleoside phosphorylase; Provisional; Region: PRK08202 525897001106 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 525897001107 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 525897001108 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525897001109 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 525897001110 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 525897001111 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 525897001112 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 525897001113 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 525897001114 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 525897001115 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 525897001116 dimer interface [polypeptide binding]; other site 525897001117 ssDNA binding site [nucleotide binding]; other site 525897001118 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525897001119 Protein of unknown function (DUF330); Region: DUF330; pfam03886 525897001120 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 525897001121 mce related protein; Region: MCE; pfam02470 525897001122 mce related protein; Region: MCE; pfam02470 525897001123 mce related protein; Region: MCE; pfam02470 525897001124 Paraquat-inducible protein A; Region: PqiA; pfam04403 525897001125 Paraquat-inducible protein A; Region: PqiA; pfam04403 525897001126 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 525897001127 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 525897001128 Mechanosensitive ion channel; Region: MS_channel; pfam00924 525897001129 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 525897001130 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525897001131 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525897001132 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 525897001133 Uncharacterized conserved protein [Function unknown]; Region: COG2006 525897001134 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897001135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001136 active site 525897001137 phosphorylation site [posttranslational modification] 525897001138 intermolecular recognition site; other site 525897001139 dimerization interface [polypeptide binding]; other site 525897001140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897001141 Walker A motif; other site 525897001142 ATP binding site [chemical binding]; other site 525897001143 Walker B motif; other site 525897001144 arginine finger; other site 525897001145 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897001146 dimerization interface [polypeptide binding]; other site 525897001147 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 525897001148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 525897001149 putative active site [active] 525897001150 heme pocket [chemical binding]; other site 525897001151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897001152 dimer interface [polypeptide binding]; other site 525897001153 phosphorylation site [posttranslational modification] 525897001154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897001155 ATP binding site [chemical binding]; other site 525897001156 Mg2+ binding site [ion binding]; other site 525897001157 G-X-G motif; other site 525897001158 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 525897001159 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 525897001160 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 525897001161 TrkA-N domain; Region: TrkA_N; pfam02254 525897001162 TrkA-C domain; Region: TrkA_C; pfam02080 525897001163 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 525897001164 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 525897001165 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 525897001166 mercuric reductase; Validated; Region: PRK06370 525897001167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525897001168 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 525897001169 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525897001170 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 525897001171 substrate binding pocket [chemical binding]; other site 525897001172 membrane-bound complex binding site; other site 525897001173 hinge residues; other site 525897001174 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 525897001175 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 525897001176 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 525897001177 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 525897001178 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 525897001179 anti sigma factor interaction site; other site 525897001180 regulatory phosphorylation site [posttranslational modification]; other site 525897001181 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 525897001182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897001183 ATP binding site [chemical binding]; other site 525897001184 Mg2+ binding site [ion binding]; other site 525897001185 G-X-G motif; other site 525897001186 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525897001187 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525897001188 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 525897001189 Walker A/P-loop; other site 525897001190 ATP binding site [chemical binding]; other site 525897001191 Q-loop/lid; other site 525897001192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897001193 ABC transporter signature motif; other site 525897001194 Walker B; other site 525897001195 D-loop; other site 525897001196 H-loop/switch region; other site 525897001197 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 525897001198 ligand binding site [chemical binding]; other site 525897001199 flexible hinge region; other site 525897001200 OPT oligopeptide transporter protein; Region: OPT; cl14607 525897001201 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 525897001202 PA/protease or protease-like domain interface [polypeptide binding]; other site 525897001203 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 525897001204 metal binding site [ion binding]; metal-binding site 525897001205 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 525897001206 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525897001207 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 525897001208 FtsX-like permease family; Region: FtsX; pfam02687 525897001209 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525897001210 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525897001211 Walker A/P-loop; other site 525897001212 ATP binding site [chemical binding]; other site 525897001213 Q-loop/lid; other site 525897001214 ABC transporter signature motif; other site 525897001215 Walker B; other site 525897001216 D-loop; other site 525897001217 H-loop/switch region; other site 525897001218 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 525897001219 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 525897001220 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 525897001221 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525897001222 catalytic core [active] 525897001223 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 525897001224 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 525897001225 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897001226 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 525897001227 putative ADP-binding pocket [chemical binding]; other site 525897001228 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 525897001229 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525897001230 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 525897001231 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 525897001232 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 525897001233 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 525897001234 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 525897001235 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 525897001236 ligand binding site [chemical binding]; other site 525897001237 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 525897001238 ligand binding site; other site 525897001239 tetramer interface; other site 525897001240 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 525897001241 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 525897001242 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 525897001243 Substrate binding site; other site 525897001244 metal-binding site 525897001245 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 525897001246 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 525897001247 putative trimer interface [polypeptide binding]; other site 525897001248 putative CoA binding site [chemical binding]; other site 525897001249 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 525897001250 NeuB family; Region: NeuB; pfam03102 525897001251 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 525897001252 NeuB binding interface [polypeptide binding]; other site 525897001253 putative substrate binding site [chemical binding]; other site 525897001254 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 525897001255 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 525897001256 active site 525897001257 homodimer interface [polypeptide binding]; other site 525897001258 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 525897001259 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 525897001260 inhibitor-cofactor binding pocket; inhibition site 525897001261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897001262 catalytic residue [active] 525897001263 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 525897001264 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 525897001265 NAD binding site [chemical binding]; other site 525897001266 substrate binding site [chemical binding]; other site 525897001267 active site 525897001268 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 525897001269 AAA domain; Region: AAA_30; pfam13604 525897001270 Family description; Region: UvrD_C_2; pfam13538 525897001271 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 525897001272 Part of AAA domain; Region: AAA_19; pfam13245 525897001273 Family description; Region: UvrD_C_2; pfam13538 525897001274 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 525897001275 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 525897001276 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897001277 Zn2+ binding site [ion binding]; other site 525897001278 Mg2+ binding site [ion binding]; other site 525897001279 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 525897001280 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 525897001281 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 525897001282 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525897001283 dimerization interface [polypeptide binding]; other site 525897001284 putative DNA binding site [nucleotide binding]; other site 525897001285 putative Zn2+ binding site [ion binding]; other site 525897001286 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525897001287 active site residue [active] 525897001288 Uncharacterized conserved protein [Function unknown]; Region: COG1633 525897001289 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 525897001290 diiron binding motif [ion binding]; other site 525897001291 aminodeoxychorismate synthase; Provisional; Region: PRK07508 525897001292 chorismate binding enzyme; Region: Chorismate_bind; cl10555 525897001293 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 525897001294 hypothetical protein; Provisional; Region: PRK07546 525897001295 substrate-cofactor binding pocket; other site 525897001296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897001297 catalytic residue [active] 525897001298 Methylamine utilisation protein MauE; Region: MauE; pfam07291 525897001299 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525897001300 active site residue [active] 525897001301 putative transposase OrfB; Reviewed; Region: PHA02517 525897001302 HTH-like domain; Region: HTH_21; pfam13276 525897001303 Integrase core domain; Region: rve; pfam00665 525897001304 Integrase core domain; Region: rve_3; pfam13683 525897001305 Transposase; Region: HTH_Tnp_1; pfam01527 525897001306 Response regulator receiver domain; Region: Response_reg; pfam00072 525897001307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001308 active site 525897001309 phosphorylation site [posttranslational modification] 525897001310 intermolecular recognition site; other site 525897001311 dimerization interface [polypeptide binding]; other site 525897001312 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 525897001313 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 525897001314 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897001315 Zn2+ binding site [ion binding]; other site 525897001316 Mg2+ binding site [ion binding]; other site 525897001317 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525897001318 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525897001319 RNA binding surface [nucleotide binding]; other site 525897001320 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 525897001321 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 525897001322 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 525897001323 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 525897001324 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 525897001325 P loop; other site 525897001326 GTP binding site [chemical binding]; other site 525897001327 Smr domain; Region: Smr; pfam01713 525897001328 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 525897001329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001330 active site 525897001331 phosphorylation site [posttranslational modification] 525897001332 intermolecular recognition site; other site 525897001333 dimerization interface [polypeptide binding]; other site 525897001334 HDOD domain; Region: HDOD; pfam08668 525897001335 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897001336 Zn2+ binding site [ion binding]; other site 525897001337 Mg2+ binding site [ion binding]; other site 525897001338 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 525897001339 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525897001340 Beta-Casp domain; Region: Beta-Casp; smart01027 525897001341 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 525897001342 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 525897001343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 525897001344 S-adenosylmethionine binding site [chemical binding]; other site 525897001345 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 525897001346 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 525897001347 active site 525897001348 (T/H)XGH motif; other site 525897001349 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 525897001350 IPP transferase; Region: IPPT; pfam01715 525897001351 twin arginine translocase protein A; Provisional; Region: tatA; PRK14859 525897001352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525897001353 non-specific DNA binding site [nucleotide binding]; other site 525897001354 salt bridge; other site 525897001355 sequence-specific DNA binding site [nucleotide binding]; other site 525897001356 Cupin domain; Region: Cupin_2; pfam07883 525897001357 AMP-binding domain protein; Validated; Region: PRK08315 525897001358 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525897001359 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 525897001360 acyl-activating enzyme (AAE) consensus motif; other site 525897001361 putative AMP binding site [chemical binding]; other site 525897001362 putative active site [active] 525897001363 putative CoA binding site [chemical binding]; other site 525897001364 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 525897001365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525897001366 motif II; other site 525897001367 YGGT family; Region: YGGT; pfam02325 525897001368 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 525897001369 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 525897001370 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 525897001371 PYR/PP interface [polypeptide binding]; other site 525897001372 dimer interface [polypeptide binding]; other site 525897001373 TPP binding site [chemical binding]; other site 525897001374 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 525897001375 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 525897001376 TPP-binding site [chemical binding]; other site 525897001377 dimer interface [polypeptide binding]; other site 525897001378 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 525897001379 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 525897001380 putative valine binding site [chemical binding]; other site 525897001381 dimer interface [polypeptide binding]; other site 525897001382 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 525897001383 ketol-acid reductoisomerase; Provisional; Region: PRK05479 525897001384 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 525897001385 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 525897001386 Tetratricopeptide repeat; Region: TPR_2; pfam07719 525897001387 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 525897001388 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 525897001389 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 525897001390 Walker A motif; other site 525897001391 ATP binding site [chemical binding]; other site 525897001392 Walker B motif; other site 525897001393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 525897001394 Family of unknown function (DUF490); Region: DUF490; pfam04357 525897001395 Surface antigen; Region: Bac_surface_Ag; pfam01103 525897001396 photolyase PhrII; Region: phr2; TIGR00591 525897001397 DNA photolyase; Region: DNA_photolyase; pfam00875 525897001398 PBP superfamily domain; Region: PBP_like_2; cl17296 525897001399 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 525897001400 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 525897001401 ligand binding site [chemical binding]; other site 525897001402 Response regulator receiver domain; Region: Response_reg; pfam00072 525897001403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001404 active site 525897001405 phosphorylation site [posttranslational modification] 525897001406 intermolecular recognition site; other site 525897001407 dimerization interface [polypeptide binding]; other site 525897001408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 525897001409 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897001410 dimerization interface [polypeptide binding]; other site 525897001411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897001412 putative active site [active] 525897001413 heme pocket [chemical binding]; other site 525897001414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897001415 dimer interface [polypeptide binding]; other site 525897001416 phosphorylation site [posttranslational modification] 525897001417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897001418 ATP binding site [chemical binding]; other site 525897001419 Mg2+ binding site [ion binding]; other site 525897001420 G-X-G motif; other site 525897001421 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525897001422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001423 active site 525897001424 phosphorylation site [posttranslational modification] 525897001425 intermolecular recognition site; other site 525897001426 dimerization interface [polypeptide binding]; other site 525897001427 Response regulator receiver domain; Region: Response_reg; pfam00072 525897001428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001429 active site 525897001430 phosphorylation site [posttranslational modification] 525897001431 intermolecular recognition site; other site 525897001432 dimerization interface [polypeptide binding]; other site 525897001433 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 525897001434 putative binding surface; other site 525897001435 active site 525897001436 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 525897001437 Response regulator receiver domain; Region: Response_reg; pfam00072 525897001438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001439 active site 525897001440 phosphorylation site [posttranslational modification] 525897001441 intermolecular recognition site; other site 525897001442 dimerization interface [polypeptide binding]; other site 525897001443 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 525897001444 GAF domain; Region: GAF_2; pfam13185 525897001445 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 525897001446 type II secretion system protein E; Region: type_II_gspE; TIGR02533 525897001447 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 525897001448 Walker A motif; other site 525897001449 ATP binding site [chemical binding]; other site 525897001450 Walker B motif; other site 525897001451 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 525897001452 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 525897001453 putative dimer interface [polypeptide binding]; other site 525897001454 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 525897001455 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 525897001456 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 525897001457 protein binding site [polypeptide binding]; other site 525897001458 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 525897001459 alanine racemase; Reviewed; Region: alr; PRK00053 525897001460 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 525897001461 active site 525897001462 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525897001463 dimer interface [polypeptide binding]; other site 525897001464 substrate binding site [chemical binding]; other site 525897001465 catalytic residues [active] 525897001466 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 525897001467 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 525897001468 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525897001469 catalytic residue [active] 525897001470 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 525897001471 NlpC/P60 family; Region: NLPC_P60; pfam00877 525897001472 NlpC/P60 family; Region: NLPC_P60; pfam00877 525897001473 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 525897001474 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 525897001475 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 525897001476 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525897001477 ATP binding site [chemical binding]; other site 525897001478 putative Mg++ binding site [ion binding]; other site 525897001479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525897001480 nucleotide binding region [chemical binding]; other site 525897001481 ATP-binding site [chemical binding]; other site 525897001482 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 525897001483 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897001484 Zn2+ binding site [ion binding]; other site 525897001485 Mg2+ binding site [ion binding]; other site 525897001486 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 525897001487 synthetase active site [active] 525897001488 NTP binding site [chemical binding]; other site 525897001489 metal binding site [ion binding]; metal-binding site 525897001490 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 525897001491 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 525897001492 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 525897001493 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 525897001494 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 525897001495 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 525897001496 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 525897001497 G1 box; other site 525897001498 putative GEF interaction site [polypeptide binding]; other site 525897001499 GTP/Mg2+ binding site [chemical binding]; other site 525897001500 Switch I region; other site 525897001501 G2 box; other site 525897001502 G3 box; other site 525897001503 Switch II region; other site 525897001504 G4 box; other site 525897001505 G5 box; other site 525897001506 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 525897001507 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 525897001508 EamA-like transporter family; Region: EamA; pfam00892 525897001509 EamA-like transporter family; Region: EamA; pfam00892 525897001510 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 525897001511 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525897001512 DNA-binding site [nucleotide binding]; DNA binding site 525897001513 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525897001514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897001515 homodimer interface [polypeptide binding]; other site 525897001516 catalytic residue [active] 525897001517 Transposase IS200 like; Region: Y1_Tnp; cl00848 525897001518 Transposase IS200 like; Region: Y1_Tnp; cl00848 525897001519 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 525897001520 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 525897001521 GTP-binding protein YchF; Reviewed; Region: PRK09601 525897001522 YchF GTPase; Region: YchF; cd01900 525897001523 G1 box; other site 525897001524 GTP/Mg2+ binding site [chemical binding]; other site 525897001525 Switch I region; other site 525897001526 G2 box; other site 525897001527 Switch II region; other site 525897001528 G3 box; other site 525897001529 G4 box; other site 525897001530 G5 box; other site 525897001531 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 525897001532 aspartate aminotransferase; Provisional; Region: PRK05764 525897001533 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525897001534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897001535 homodimer interface [polypeptide binding]; other site 525897001536 catalytic residue [active] 525897001537 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 525897001538 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 525897001539 Methyltransferase domain; Region: Methyltransf_23; pfam13489 525897001540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897001541 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 525897001542 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 525897001543 active site 525897001544 trimerization site [polypeptide binding]; other site 525897001545 CGGC domain; Region: CGGC; cl02356 525897001546 Transposase; Region: DEDD_Tnp_IS110; pfam01548 525897001547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 525897001548 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 525897001549 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 525897001550 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 525897001551 synthetase active site [active] 525897001552 NTP binding site [chemical binding]; other site 525897001553 metal binding site [ion binding]; metal-binding site 525897001554 EamA-like transporter family; Region: EamA; cl17759 525897001555 EamA-like transporter family; Region: EamA; pfam00892 525897001556 4Fe-4S binding domain; Region: Fer4_6; pfam12837 525897001557 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 525897001558 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 525897001559 putative FMN binding site [chemical binding]; other site 525897001560 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 525897001561 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 525897001562 Predicted transcriptional regulators [Transcription]; Region: COG1733 525897001563 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 525897001564 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 525897001565 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 525897001566 Protein of unknown function (DUF401); Region: DUF401; cl00830 525897001567 hypothetical protein; Provisional; Region: PRK02250 525897001568 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 525897001569 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 525897001570 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 525897001571 homotrimer interaction site [polypeptide binding]; other site 525897001572 putative active site [active] 525897001573 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 525897001574 Protein of unknown function (DUF330); Region: DUF330; cl01135 525897001575 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 525897001576 mce related protein; Region: MCE; pfam02470 525897001577 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 525897001578 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 525897001579 Walker A/P-loop; other site 525897001580 ATP binding site [chemical binding]; other site 525897001581 Q-loop/lid; other site 525897001582 ABC transporter signature motif; other site 525897001583 Walker B; other site 525897001584 D-loop; other site 525897001585 H-loop/switch region; other site 525897001586 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 525897001587 anti sigma factor interaction site; other site 525897001588 regulatory phosphorylation site [posttranslational modification]; other site 525897001589 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 525897001590 Permease; Region: Permease; pfam02405 525897001591 PAS domain S-box; Region: sensory_box; TIGR00229 525897001592 PAS domain; Region: PAS_9; pfam13426 525897001593 PAS fold; Region: PAS_3; pfam08447 525897001594 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897001595 putative active site [active] 525897001596 heme pocket [chemical binding]; other site 525897001597 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897001598 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897001599 metal binding site [ion binding]; metal-binding site 525897001600 active site 525897001601 I-site; other site 525897001602 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 525897001603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897001604 TPR motif; other site 525897001605 binding surface 525897001606 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 525897001607 DNA protecting protein DprA; Region: dprA; TIGR00732 525897001608 HDOD domain; Region: HDOD; pfam08668 525897001609 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897001610 Zn2+ binding site [ion binding]; other site 525897001611 Mg2+ binding site [ion binding]; other site 525897001612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001613 active site 525897001614 phosphorylation site [posttranslational modification] 525897001615 intermolecular recognition site; other site 525897001616 dimerization interface [polypeptide binding]; other site 525897001617 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897001618 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897001619 metal binding site [ion binding]; metal-binding site 525897001620 active site 525897001621 I-site; other site 525897001622 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 525897001623 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 525897001624 active site 525897001625 Int/Topo IB signature motif; other site 525897001626 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 525897001627 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 525897001628 PilZ domain; Region: PilZ; pfam07238 525897001629 NIL domain; Region: NIL; pfam09383 525897001630 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 525897001631 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897001632 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 525897001633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897001634 TPR motif; other site 525897001635 binding surface 525897001636 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 525897001637 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 525897001638 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 525897001639 lipoprotein signal peptidase; Provisional; Region: PRK14787 525897001640 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 525897001641 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525897001642 active site 525897001643 HIGH motif; other site 525897001644 nucleotide binding site [chemical binding]; other site 525897001645 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 525897001646 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 525897001647 active site 525897001648 KMSKS motif; other site 525897001649 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 525897001650 tRNA binding surface [nucleotide binding]; other site 525897001651 anticodon binding site; other site 525897001652 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 525897001653 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 525897001654 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 525897001655 NAD binding site [chemical binding]; other site 525897001656 homodimer interface [polypeptide binding]; other site 525897001657 active site 525897001658 substrate binding site [chemical binding]; other site 525897001659 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 525897001660 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 525897001661 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 525897001662 Peptidase M16C associated; Region: M16C_assoc; pfam08367 525897001663 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897001664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001665 active site 525897001666 phosphorylation site [posttranslational modification] 525897001667 intermolecular recognition site; other site 525897001668 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 525897001669 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 525897001670 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897001671 Zn2+ binding site [ion binding]; other site 525897001672 Mg2+ binding site [ion binding]; other site 525897001673 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897001674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001675 active site 525897001676 phosphorylation site [posttranslational modification] 525897001677 intermolecular recognition site; other site 525897001678 dimerization interface [polypeptide binding]; other site 525897001679 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 525897001680 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897001681 Zn2+ binding site [ion binding]; other site 525897001682 Mg2+ binding site [ion binding]; other site 525897001683 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897001684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001685 active site 525897001686 phosphorylation site [posttranslational modification] 525897001687 intermolecular recognition site; other site 525897001688 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 525897001689 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897001690 Zn2+ binding site [ion binding]; other site 525897001691 Mg2+ binding site [ion binding]; other site 525897001692 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 525897001693 CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655 525897001694 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 525897001695 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525897001696 Ligand Binding Site [chemical binding]; other site 525897001697 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 525897001698 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 525897001699 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897001700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897001701 dimer interface [polypeptide binding]; other site 525897001702 phosphorylation site [posttranslational modification] 525897001703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897001704 ATP binding site [chemical binding]; other site 525897001705 Mg2+ binding site [ion binding]; other site 525897001706 G-X-G motif; other site 525897001707 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897001708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001709 active site 525897001710 phosphorylation site [posttranslational modification] 525897001711 intermolecular recognition site; other site 525897001712 dimerization interface [polypeptide binding]; other site 525897001713 Response regulator receiver domain; Region: Response_reg; pfam00072 525897001714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001715 active site 525897001716 phosphorylation site [posttranslational modification] 525897001717 intermolecular recognition site; other site 525897001718 dimerization interface [polypeptide binding]; other site 525897001719 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 525897001720 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 525897001721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897001722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897001723 dimer interface [polypeptide binding]; other site 525897001724 phosphorylation site [posttranslational modification] 525897001725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897001726 ATP binding site [chemical binding]; other site 525897001727 Mg2+ binding site [ion binding]; other site 525897001728 G-X-G motif; other site 525897001729 Response regulator receiver domain; Region: Response_reg; pfam00072 525897001730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001731 active site 525897001732 phosphorylation site [posttranslational modification] 525897001733 intermolecular recognition site; other site 525897001734 dimerization interface [polypeptide binding]; other site 525897001735 Response regulator receiver domain; Region: Response_reg; pfam00072 525897001736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001737 active site 525897001738 phosphorylation site [posttranslational modification] 525897001739 intermolecular recognition site; other site 525897001740 dimerization interface [polypeptide binding]; other site 525897001741 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897001742 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 525897001743 putative ADP-binding pocket [chemical binding]; other site 525897001744 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 525897001745 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525897001746 selenocysteine synthase; Provisional; Region: PRK04311 525897001747 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 525897001748 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 525897001749 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525897001750 catalytic residue [active] 525897001751 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 525897001752 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525897001753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897001754 homodimer interface [polypeptide binding]; other site 525897001755 catalytic residue [active] 525897001756 cytidylate kinase; Provisional; Region: cmk; PRK00023 525897001757 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 525897001758 CMP-binding site; other site 525897001759 The sites determining sugar specificity; other site 525897001760 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 525897001761 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 525897001762 homodimer interface [polypeptide binding]; other site 525897001763 metal binding site [ion binding]; metal-binding site 525897001764 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 525897001765 homodimer interface [polypeptide binding]; other site 525897001766 active site 525897001767 putative chemical substrate binding site [chemical binding]; other site 525897001768 metal binding site [ion binding]; metal-binding site 525897001769 Colicin V production protein; Region: Colicin_V; pfam02674 525897001770 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 525897001771 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897001772 FeS/SAM binding site; other site 525897001773 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 525897001774 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 525897001775 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 525897001776 Putative GTPase activating protein for Arf; Region: ArfGap; cl02464 525897001777 shikimate kinase; Reviewed; Region: aroK; PRK00131 525897001778 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 525897001779 ADP binding site [chemical binding]; other site 525897001780 magnesium binding site [ion binding]; other site 525897001781 putative shikimate binding site; other site 525897001782 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 525897001783 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 525897001784 Walker A/P-loop; other site 525897001785 ATP binding site [chemical binding]; other site 525897001786 Q-loop/lid; other site 525897001787 ABC transporter signature motif; other site 525897001788 Walker B; other site 525897001789 D-loop; other site 525897001790 H-loop/switch region; other site 525897001791 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 525897001792 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 525897001793 Walker A/P-loop; other site 525897001794 ATP binding site [chemical binding]; other site 525897001795 Q-loop/lid; other site 525897001796 ABC transporter signature motif; other site 525897001797 Walker B; other site 525897001798 D-loop; other site 525897001799 H-loop/switch region; other site 525897001800 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 525897001801 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 525897001802 TM-ABC transporter signature motif; other site 525897001803 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525897001804 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 525897001805 TM-ABC transporter signature motif; other site 525897001806 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 525897001807 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 525897001808 putative ligand binding site [chemical binding]; other site 525897001809 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 525897001810 dimer interface [polypeptide binding]; other site 525897001811 active site 525897001812 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 525897001813 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 525897001814 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 525897001815 domain interfaces; other site 525897001816 active site 525897001817 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 525897001818 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 525897001819 putative dimer interface [polypeptide binding]; other site 525897001820 active site pocket [active] 525897001821 putative cataytic base [active] 525897001822 Protein of unknown function (DUF523); Region: DUF523; pfam04463 525897001823 PilZ domain; Region: PilZ; pfam07238 525897001824 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 525897001825 6-phosphofructokinase; Region: PLN02884 525897001826 active site 525897001827 ADP/pyrophosphate binding site [chemical binding]; other site 525897001828 dimerization interface [polypeptide binding]; other site 525897001829 allosteric effector site; other site 525897001830 fructose-1,6-bisphosphate binding site; other site 525897001831 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 525897001832 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 525897001833 putative NAD(P) binding site [chemical binding]; other site 525897001834 putative active site [active] 525897001835 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 525897001836 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 525897001837 trimerization site [polypeptide binding]; other site 525897001838 active site 525897001839 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 525897001840 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 525897001841 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 525897001842 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525897001843 catalytic residue [active] 525897001844 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 525897001845 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 525897001846 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 525897001847 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 525897001848 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525897001849 active site 525897001850 HIGH motif; other site 525897001851 nucleotide binding site [chemical binding]; other site 525897001852 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 525897001853 KMSKS motif; other site 525897001854 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 525897001855 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 525897001856 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 525897001857 nudix motif; other site 525897001858 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 525897001859 FMN binding site [chemical binding]; other site 525897001860 dimer interface [polypeptide binding]; other site 525897001861 Protein of unknown function, DUF606; Region: DUF606; pfam04657 525897001862 DsrE/DsrF-like family; Region: DrsE; pfam02635 525897001863 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 525897001864 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 525897001865 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 525897001866 DNA-binding site [nucleotide binding]; DNA binding site 525897001867 RNA-binding motif; other site 525897001868 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 525897001869 Glucokinase; Region: Glucokinase; cl17310 525897001870 glucokinase, proteobacterial type; Region: glk; TIGR00749 525897001871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525897001872 non-specific DNA binding site [nucleotide binding]; other site 525897001873 salt bridge; other site 525897001874 sequence-specific DNA binding site [nucleotide binding]; other site 525897001875 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 525897001876 4Fe-4S binding domain; Region: Fer4; pfam00037 525897001877 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897001878 4Fe-4S binding domain; Region: Fer4; pfam00037 525897001879 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525897001880 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 525897001881 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 525897001882 active site 525897001883 catalytic site [active] 525897001884 substrate binding site [chemical binding]; other site 525897001885 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 525897001886 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 525897001887 ligand binding site [chemical binding]; other site 525897001888 flexible hinge region; other site 525897001889 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 525897001890 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 525897001891 metal binding triad; other site 525897001892 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 525897001893 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 525897001894 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 525897001895 Na binding site [ion binding]; other site 525897001896 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 525897001897 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 525897001898 putative ADP-ribose binding site [chemical binding]; other site 525897001899 putative active site [active] 525897001900 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 525897001901 active site 525897001902 metal binding site [ion binding]; metal-binding site 525897001903 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 525897001904 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525897001905 ATP binding site [chemical binding]; other site 525897001906 putative Mg++ binding site [ion binding]; other site 525897001907 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525897001908 nucleotide binding region [chemical binding]; other site 525897001909 ATP-binding site [chemical binding]; other site 525897001910 Helicase associated domain (HA2); Region: HA2; pfam04408 525897001911 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 525897001912 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 525897001913 tetramer interfaces [polypeptide binding]; other site 525897001914 binuclear metal-binding site [ion binding]; other site 525897001915 Maf-like protein; Reviewed; Region: PRK00078 525897001916 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 525897001917 active site 525897001918 dimer interface [polypeptide binding]; other site 525897001919 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 525897001920 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525897001921 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 525897001922 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 525897001923 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 525897001924 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525897001925 Cysteine-rich domain; Region: CCG; pfam02754 525897001926 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525897001927 heme-binding residues [chemical binding]; other site 525897001928 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525897001929 heme-binding residues [chemical binding]; other site 525897001930 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525897001931 heme-binding residues [chemical binding]; other site 525897001932 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525897001933 heme-binding residues [chemical binding]; other site 525897001934 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525897001935 heme-binding residues [chemical binding]; other site 525897001936 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 525897001937 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 525897001938 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 525897001939 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525897001940 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525897001941 Ligand Binding Site [chemical binding]; other site 525897001942 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525897001943 Ligand Binding Site [chemical binding]; other site 525897001944 Response regulator receiver domain; Region: Response_reg; pfam00072 525897001945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001946 active site 525897001947 phosphorylation site [posttranslational modification] 525897001948 intermolecular recognition site; other site 525897001949 dimerization interface [polypeptide binding]; other site 525897001950 Response regulator receiver domain; Region: Response_reg; pfam00072 525897001951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897001952 active site 525897001953 phosphorylation site [posttranslational modification] 525897001954 dimerization interface [polypeptide binding]; other site 525897001955 PAS fold; Region: PAS_4; pfam08448 525897001956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897001957 ATP binding site [chemical binding]; other site 525897001958 Mg2+ binding site [ion binding]; other site 525897001959 G-X-G motif; other site 525897001960 Transcriptional regulator; Region: Rrf2; cl17282 525897001961 Rrf2 family protein; Region: rrf2_super; TIGR00738 525897001962 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 525897001963 FMN binding site [chemical binding]; other site 525897001964 dimer interface [polypeptide binding]; other site 525897001965 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 525897001966 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 525897001967 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 525897001968 endonuclease III; Region: ENDO3c; smart00478 525897001969 minor groove reading motif; other site 525897001970 helix-hairpin-helix signature motif; other site 525897001971 substrate binding pocket [chemical binding]; other site 525897001972 active site 525897001973 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 525897001974 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 525897001975 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14337 525897001976 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 525897001977 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897001978 FeS/SAM binding site; other site 525897001979 TRAM domain; Region: TRAM; cl01282 525897001980 Bifunctional nuclease; Region: DNase-RNase; pfam02577 525897001981 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 525897001982 active site 525897001983 hypothetical protein; Provisional; Region: PRK06361 525897001984 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 525897001985 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 525897001986 TolR protein; Region: tolR; TIGR02801 525897001987 TonB C terminal; Region: TonB_2; pfam13103 525897001988 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 525897001989 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 525897001990 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 525897001991 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 525897001992 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 525897001993 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 525897001994 ligand binding site [chemical binding]; other site 525897001995 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 525897001996 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 525897001997 Ligand binding site; other site 525897001998 DXD motif; other site 525897001999 probable phenylalanyl-tRNA synthetase beta chain; Region: PLN02265 525897002000 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 525897002001 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 525897002002 Nif-specific regulatory protein; Region: nifA; TIGR01817 525897002003 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 525897002004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897002005 Walker A motif; other site 525897002006 ATP binding site [chemical binding]; other site 525897002007 Walker B motif; other site 525897002008 arginine finger; other site 525897002009 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897002010 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 525897002011 hybrid cluster protein; Provisional; Region: PRK05290 525897002012 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897002013 ACS interaction site; other site 525897002014 CODH interaction site; other site 525897002015 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 525897002016 hybrid metal cluster; other site 525897002017 putative glutamate synthase subunit beta; Provisional; Region: PRK12770 525897002018 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 525897002019 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525897002020 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 525897002021 4Fe-4S binding domain; Region: Fer4_5; pfam12801 525897002022 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897002023 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 525897002024 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897002025 GTPase RsgA; Reviewed; Region: PRK01889 525897002026 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 525897002027 GTPase/Zn-binding domain interface [polypeptide binding]; other site 525897002028 GTP/Mg2+ binding site [chemical binding]; other site 525897002029 G4 box; other site 525897002030 G5 box; other site 525897002031 G1 box; other site 525897002032 Switch I region; other site 525897002033 G2 box; other site 525897002034 G3 box; other site 525897002035 Switch II region; other site 525897002036 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 525897002037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897002038 S-adenosylmethionine binding site [chemical binding]; other site 525897002039 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 525897002040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897002041 S-adenosylmethionine binding site [chemical binding]; other site 525897002042 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 525897002043 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 525897002044 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 525897002045 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 525897002046 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 525897002047 Transcriptional regulator [Transcription]; Region: IclR; COG1414 525897002048 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 525897002049 Bacterial transcriptional regulator; Region: IclR; pfam01614 525897002050 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 525897002051 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 525897002052 putative ligand binding site [chemical binding]; other site 525897002053 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525897002054 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 525897002055 TM-ABC transporter signature motif; other site 525897002056 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 525897002057 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 525897002058 TM-ABC transporter signature motif; other site 525897002059 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 525897002060 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 525897002061 Walker A/P-loop; other site 525897002062 ATP binding site [chemical binding]; other site 525897002063 Q-loop/lid; other site 525897002064 ABC transporter signature motif; other site 525897002065 Walker B; other site 525897002066 D-loop; other site 525897002067 H-loop/switch region; other site 525897002068 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 525897002069 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 525897002070 Walker A/P-loop; other site 525897002071 ATP binding site [chemical binding]; other site 525897002072 Q-loop/lid; other site 525897002073 ABC transporter signature motif; other site 525897002074 Walker B; other site 525897002075 D-loop; other site 525897002076 H-loop/switch region; other site 525897002077 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 525897002078 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 525897002079 FAD binding pocket [chemical binding]; other site 525897002080 FAD binding motif [chemical binding]; other site 525897002081 phosphate binding motif [ion binding]; other site 525897002082 beta-alpha-beta structure motif; other site 525897002083 NAD binding pocket [chemical binding]; other site 525897002084 Iron coordination center [ion binding]; other site 525897002085 putative oxidoreductase; Provisional; Region: PRK12831 525897002086 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897002087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 525897002088 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525897002089 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 525897002090 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 525897002091 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 525897002092 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 525897002093 DctM-like transporters; Region: DctM; pfam06808 525897002094 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 525897002095 metal binding site 2 [ion binding]; metal-binding site 525897002096 putative DNA binding helix; other site 525897002097 metal binding site 1 [ion binding]; metal-binding site 525897002098 dimer interface [polypeptide binding]; other site 525897002099 structural Zn2+ binding site [ion binding]; other site 525897002100 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 525897002101 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 525897002102 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 525897002103 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 525897002104 putative metal binding residues [ion binding]; other site 525897002105 4Fe-4S binding domain; Region: Fer4; pfam00037 525897002106 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897002107 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 525897002108 putative FMN binding site [chemical binding]; other site 525897002109 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 525897002110 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 525897002111 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 525897002112 FAD binding site [chemical binding]; other site 525897002113 Bacterial SH3 domain; Region: SH3_3; pfam08239 525897002114 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897002115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897002116 active site 525897002117 phosphorylation site [posttranslational modification] 525897002118 intermolecular recognition site; other site 525897002119 dimerization interface [polypeptide binding]; other site 525897002120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897002121 Walker A motif; other site 525897002122 ATP binding site [chemical binding]; other site 525897002123 Walker B motif; other site 525897002124 arginine finger; other site 525897002125 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897002126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897002127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897002128 dimer interface [polypeptide binding]; other site 525897002129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897002130 ATP binding site [chemical binding]; other site 525897002131 G-X-G motif; other site 525897002132 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 525897002133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897002134 Walker A/P-loop; other site 525897002135 ATP binding site [chemical binding]; other site 525897002136 Q-loop/lid; other site 525897002137 ABC transporter signature motif; other site 525897002138 Walker B; other site 525897002139 D-loop; other site 525897002140 H-loop/switch region; other site 525897002141 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525897002142 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 525897002143 TM-ABC transporter signature motif; other site 525897002144 CHASE2 domain; Region: CHASE2; pfam05226 525897002145 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897002146 Zn2+ binding site [ion binding]; other site 525897002147 Mg2+ binding site [ion binding]; other site 525897002148 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 525897002149 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 525897002150 ligand binding site [chemical binding]; other site 525897002151 FecR protein; Region: FecR; pfam04773 525897002152 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 525897002153 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525897002154 ATP binding site [chemical binding]; other site 525897002155 putative Mg++ binding site [ion binding]; other site 525897002156 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525897002157 nucleotide binding region [chemical binding]; other site 525897002158 ATP-binding site [chemical binding]; other site 525897002159 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 525897002160 HRDC domain; Region: HRDC; pfam00570 525897002161 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 525897002162 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 525897002163 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 525897002164 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525897002165 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 525897002166 intersubunit interface [polypeptide binding]; other site 525897002167 active site 525897002168 catalytic residue [active] 525897002169 phosphopentomutase; Provisional; Region: PRK05362 525897002170 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 525897002171 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 525897002172 Domain of unknown function DUF20; Region: UPF0118; pfam01594 525897002173 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897002174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897002175 active site 525897002176 phosphorylation site [posttranslational modification] 525897002177 intermolecular recognition site; other site 525897002178 dimerization interface [polypeptide binding]; other site 525897002179 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 525897002180 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 525897002181 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 525897002182 Double zinc ribbon; Region: DZR; pfam12773 525897002183 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 525897002184 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 525897002185 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 525897002186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525897002187 active site 525897002188 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 525897002189 dihydrodipicolinate synthase; Region: dapA; TIGR00674 525897002190 dimer interface [polypeptide binding]; other site 525897002191 active site 525897002192 catalytic residue [active] 525897002193 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 525897002194 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 525897002195 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 525897002196 peptide synthase; Provisional; Region: PRK12316 525897002197 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 525897002198 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525897002199 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 525897002200 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525897002201 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897002202 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897002203 metal binding site [ion binding]; metal-binding site 525897002204 active site 525897002205 I-site; other site 525897002206 peptide chain release factor 2; Validated; Region: prfB; PRK00578 525897002207 This domain is found in peptide chain release factors; Region: PCRF; smart00937 525897002208 RF-1 domain; Region: RF-1; pfam00472 525897002209 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 525897002210 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 525897002211 putative active site [active] 525897002212 catalytic triad [active] 525897002213 putative dimer interface [polypeptide binding]; other site 525897002214 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 525897002215 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 525897002216 Transporter associated domain; Region: CorC_HlyC; smart01091 525897002217 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 525897002218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 525897002219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897002220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897002221 dimer interface [polypeptide binding]; other site 525897002222 phosphorylation site [posttranslational modification] 525897002223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897002224 ATP binding site [chemical binding]; other site 525897002225 Mg2+ binding site [ion binding]; other site 525897002226 G-X-G motif; other site 525897002227 Response regulator receiver domain; Region: Response_reg; pfam00072 525897002228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897002229 active site 525897002230 phosphorylation site [posttranslational modification] 525897002231 intermolecular recognition site; other site 525897002232 dimerization interface [polypeptide binding]; other site 525897002233 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 525897002234 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 525897002235 G1 box; other site 525897002236 GTP/Mg2+ binding site [chemical binding]; other site 525897002237 G2 box; other site 525897002238 Switch I region; other site 525897002239 G3 box; other site 525897002240 Switch II region; other site 525897002241 G4 box; other site 525897002242 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 525897002243 RNA methyltransferase, RsmE family; Region: TIGR00046 525897002244 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 525897002245 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 525897002246 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 525897002247 GAF domain; Region: GAF; pfam01590 525897002248 GAF domain; Region: GAF_2; pfam13185 525897002249 GAF domain; Region: GAF_3; pfam13492 525897002250 GAF domain; Region: GAF_2; pfam13185 525897002251 rod shape-determining protein MreB; Provisional; Region: PRK13930 525897002252 MreB and similar proteins; Region: MreB_like; cd10225 525897002253 nucleotide binding site [chemical binding]; other site 525897002254 Mg binding site [ion binding]; other site 525897002255 putative protofilament interaction site [polypeptide binding]; other site 525897002256 RodZ interaction site [polypeptide binding]; other site 525897002257 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 525897002258 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 525897002259 nudix motif; other site 525897002260 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 525897002261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525897002262 Coenzyme A binding pocket [chemical binding]; other site 525897002263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897002264 S-adenosylmethionine binding site [chemical binding]; other site 525897002265 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 525897002266 substrate binding site [chemical binding]; other site 525897002267 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 525897002268 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 525897002269 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 525897002270 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 525897002271 protein binding site [polypeptide binding]; other site 525897002272 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 525897002273 protein binding site [polypeptide binding]; other site 525897002274 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14615 525897002275 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 525897002276 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 525897002277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525897002278 active site 525897002279 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 525897002280 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 525897002281 5S rRNA interface [nucleotide binding]; other site 525897002282 CTC domain interface [polypeptide binding]; other site 525897002283 L16 interface [polypeptide binding]; other site 525897002284 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 525897002285 putative active site [active] 525897002286 catalytic residue [active] 525897002287 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 525897002288 transcription termination factor Rho; Provisional; Region: rho; PRK09376 525897002289 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 525897002290 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 525897002291 RNA binding site [nucleotide binding]; other site 525897002292 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 525897002293 multimer interface [polypeptide binding]; other site 525897002294 Walker A motif; other site 525897002295 ATP binding site [chemical binding]; other site 525897002296 Walker B motif; other site 525897002297 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 525897002298 NAD+ synthetase; Region: nadE; TIGR00552 525897002299 Ligand Binding Site [chemical binding]; other site 525897002300 Peptidase family M48; Region: Peptidase_M48; cl12018 525897002301 Tetratricopeptide repeat; Region: TPR_16; pfam13432 525897002302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897002303 binding surface 525897002304 TPR motif; other site 525897002305 Tetratricopeptide repeat; Region: TPR_16; pfam13432 525897002306 Preprotein translocase subunit; Region: YajC; pfam02699 525897002307 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 525897002308 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 525897002309 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 525897002310 Protein export membrane protein; Region: SecD_SecF; pfam02355 525897002311 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525897002312 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 525897002313 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 525897002314 L-aspartate oxidase; Provisional; Region: PRK06175 525897002315 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 525897002316 quinolinate synthetase; Provisional; Region: PRK09375 525897002317 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 525897002318 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 525897002319 dimerization interface [polypeptide binding]; other site 525897002320 active site 525897002321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897002322 TPR motif; other site 525897002323 binding surface 525897002324 Tetratricopeptide repeat; Region: TPR_16; pfam13432 525897002325 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 525897002326 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 525897002327 putative active site [active] 525897002328 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 525897002329 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 525897002330 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 525897002331 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 525897002332 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 525897002333 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 525897002334 active site 525897002335 metal binding site [ion binding]; metal-binding site 525897002336 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 525897002337 putative catalytic site [active] 525897002338 putative metal binding site [ion binding]; other site 525897002339 putative phosphate binding site [ion binding]; other site 525897002340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525897002341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525897002342 DsrE/DsrF-like family; Region: DrsE; pfam02635 525897002343 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 525897002344 hypothetical protein; Reviewed; Region: PRK09588 525897002345 aspartate kinase; Reviewed; Region: PRK06635 525897002346 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 525897002347 putative nucleotide binding site [chemical binding]; other site 525897002348 putative catalytic residues [active] 525897002349 putative Mg ion binding site [ion binding]; other site 525897002350 putative aspartate binding site [chemical binding]; other site 525897002351 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525897002352 Ligand Binding Site [chemical binding]; other site 525897002353 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 525897002354 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 525897002355 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 525897002356 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 525897002357 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 525897002358 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 525897002359 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 525897002360 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525897002361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897002362 homodimer interface [polypeptide binding]; other site 525897002363 catalytic residue [active] 525897002364 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 525897002365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897002366 FOG: CBS domain [General function prediction only]; Region: COG0517 525897002367 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 525897002368 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 525897002369 Predicted amidohydrolase [General function prediction only]; Region: COG0388 525897002370 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 525897002371 active site 525897002372 catalytic triad [active] 525897002373 dimer interface [polypeptide binding]; other site 525897002374 hypothetical protein; Provisional; Region: PRK04194 525897002375 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 525897002376 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 525897002377 Peptidase family U32; Region: Peptidase_U32; pfam01136 525897002378 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 525897002379 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 525897002380 active site 525897002381 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 525897002382 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 525897002383 rRNA binding site [nucleotide binding]; other site 525897002384 predicted 30S ribosome binding site; other site 525897002385 PAS domain; Region: PAS; smart00091 525897002386 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897002387 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897002388 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897002389 putative active site [active] 525897002390 heme pocket [chemical binding]; other site 525897002391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897002392 dimer interface [polypeptide binding]; other site 525897002393 phosphorylation site [posttranslational modification] 525897002394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897002395 ATP binding site [chemical binding]; other site 525897002396 Mg2+ binding site [ion binding]; other site 525897002397 G-X-G motif; other site 525897002398 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897002399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897002400 active site 525897002401 phosphorylation site [posttranslational modification] 525897002402 intermolecular recognition site; other site 525897002403 dimerization interface [polypeptide binding]; other site 525897002404 Uncharacterized conserved protein [Function unknown]; Region: COG0397 525897002405 hypothetical protein; Validated; Region: PRK00029 525897002406 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 525897002407 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 525897002408 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 525897002409 putative active site [active] 525897002410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897002411 TPR repeat; Region: TPR_11; pfam13414 525897002412 binding surface 525897002413 TPR motif; other site 525897002414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897002415 TPR repeat; Region: TPR_11; pfam13414 525897002416 binding surface 525897002417 TPR motif; other site 525897002418 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 525897002419 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897002420 dimer interface [polypeptide binding]; other site 525897002421 putative CheW interface [polypeptide binding]; other site 525897002422 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897002423 dimerization interface [polypeptide binding]; other site 525897002424 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525897002425 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897002426 dimer interface [polypeptide binding]; other site 525897002427 putative CheW interface [polypeptide binding]; other site 525897002428 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 525897002429 Bacterial SH3 domain; Region: SH3_3; pfam08239 525897002430 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 525897002431 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525897002432 putative DNA binding site [nucleotide binding]; other site 525897002433 putative Zn2+ binding site [ion binding]; other site 525897002434 HipA-like N-terminal domain; Region: HipA_N; pfam07805 525897002435 HipA-like C-terminal domain; Region: HipA_C; pfam07804 525897002436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 525897002437 Protein of unknown function (DUF497); Region: DUF497; pfam04365 525897002438 Integrase core domain; Region: rve; pfam00665 525897002439 Integrase core domain; Region: rve_3; pfam13683 525897002440 Transposase; Region: HTH_Tnp_1; pfam01527 525897002441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 525897002442 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 525897002443 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 525897002444 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 525897002445 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 525897002446 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 525897002447 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 525897002448 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 525897002449 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 525897002450 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 525897002451 Walker A/P-loop; other site 525897002452 ATP binding site [chemical binding]; other site 525897002453 Q-loop/lid; other site 525897002454 ABC transporter signature motif; other site 525897002455 Walker B; other site 525897002456 D-loop; other site 525897002457 H-loop/switch region; other site 525897002458 TOBE domain; Region: TOBE_2; pfam08402 525897002459 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 525897002460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897002461 dimer interface [polypeptide binding]; other site 525897002462 conserved gate region; other site 525897002463 putative PBP binding loops; other site 525897002464 ABC-ATPase subunit interface; other site 525897002465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897002466 dimer interface [polypeptide binding]; other site 525897002467 conserved gate region; other site 525897002468 putative PBP binding loops; other site 525897002469 ABC-ATPase subunit interface; other site 525897002470 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 525897002471 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 525897002472 Cache domain; Region: Cache_1; pfam02743 525897002473 PAS fold; Region: PAS_3; pfam08447 525897002474 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897002475 dimer interface [polypeptide binding]; other site 525897002476 phosphorylation site [posttranslational modification] 525897002477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897002478 ATP binding site [chemical binding]; other site 525897002479 Mg2+ binding site [ion binding]; other site 525897002480 G-X-G motif; other site 525897002481 Response regulator receiver domain; Region: Response_reg; pfam00072 525897002482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897002483 active site 525897002484 phosphorylation site [posttranslational modification] 525897002485 intermolecular recognition site; other site 525897002486 dimerization interface [polypeptide binding]; other site 525897002487 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 525897002488 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 525897002489 ligand binding site [chemical binding]; other site 525897002490 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 525897002491 Nuclease-related domain; Region: NERD; pfam08378 525897002492 Fic family protein [Function unknown]; Region: COG3177 525897002493 Fic/DOC family; Region: Fic; pfam02661 525897002494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 525897002495 TPR motif; other site 525897002496 binding surface 525897002497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897002498 TPR motif; other site 525897002499 binding surface 525897002500 phosphoglucomutase; Validated; Region: PRK07564 525897002501 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 525897002502 active site 525897002503 substrate binding site [chemical binding]; other site 525897002504 metal binding site [ion binding]; metal-binding site 525897002505 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525897002506 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 525897002507 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 525897002508 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 525897002509 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 525897002510 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 525897002511 FOG: CBS domain [General function prediction only]; Region: COG0517 525897002512 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 525897002513 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 525897002514 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 525897002515 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 525897002516 Peptidase family M23; Region: Peptidase_M23; pfam01551 525897002517 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 525897002518 HupF/HypC family; Region: HupF_HypC; pfam01455 525897002519 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 525897002520 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 525897002521 putative substrate-binding site; other site 525897002522 nickel binding site [ion binding]; other site 525897002523 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 525897002524 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 525897002525 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 525897002526 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 525897002527 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 525897002528 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 525897002529 dimer interface [polypeptide binding]; other site 525897002530 FMN binding site [chemical binding]; other site 525897002531 TPR repeat; Region: TPR_11; pfam13414 525897002532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897002533 binding surface 525897002534 TPR motif; other site 525897002535 TPR repeat; Region: TPR_11; pfam13414 525897002536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525897002537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 525897002538 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 525897002539 thiamine phosphate binding site [chemical binding]; other site 525897002540 active site 525897002541 pyrophosphate binding site [ion binding]; other site 525897002542 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 525897002543 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 525897002544 ATP binding site [chemical binding]; other site 525897002545 substrate interface [chemical binding]; other site 525897002546 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 525897002547 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897002548 FeS/SAM binding site; other site 525897002549 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 525897002550 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 525897002551 ThiS interaction site; other site 525897002552 putative active site [active] 525897002553 tetramer interface [polypeptide binding]; other site 525897002554 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 525897002555 thiS-thiF/thiG interaction site; other site 525897002556 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 525897002557 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 525897002558 active site 525897002559 Zn binding site [ion binding]; other site 525897002560 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 525897002561 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 525897002562 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 525897002563 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 525897002564 active site 525897002565 dimerization interface [polypeptide binding]; other site 525897002566 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 525897002567 adenylate kinase; Provisional; Region: PRK14529 525897002568 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 525897002569 AMP-binding site [chemical binding]; other site 525897002570 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 525897002571 selenobiotic family peptide radical SAM maturase; Region: rSAM_for_selen; TIGR04082 525897002572 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897002573 FeS/SAM binding site; other site 525897002574 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 525897002575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897002576 dimer interface [polypeptide binding]; other site 525897002577 conserved gate region; other site 525897002578 putative PBP binding loops; other site 525897002579 ABC-ATPase subunit interface; other site 525897002580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897002581 dimer interface [polypeptide binding]; other site 525897002582 conserved gate region; other site 525897002583 putative PBP binding loops; other site 525897002584 ABC-ATPase subunit interface; other site 525897002585 hypothetical protein; Provisional; Region: PRK11622 525897002586 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 525897002587 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 525897002588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897002589 Walker A/P-loop; other site 525897002590 ATP binding site [chemical binding]; other site 525897002591 Q-loop/lid; other site 525897002592 ABC transporter signature motif; other site 525897002593 Walker B; other site 525897002594 D-loop; other site 525897002595 H-loop/switch region; other site 525897002596 TOBE domain; Region: TOBE_2; pfam08402 525897002597 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 525897002598 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525897002599 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 525897002600 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 525897002601 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 525897002602 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 525897002603 putative NADH binding site [chemical binding]; other site 525897002604 putative active site [active] 525897002605 nudix motif; other site 525897002606 putative metal binding site [ion binding]; other site 525897002607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897002608 FeS/SAM binding site; other site 525897002609 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 525897002610 ACT domain-containing protein [General function prediction only]; Region: COG4747 525897002611 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 525897002612 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 525897002613 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525897002614 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 525897002615 acyl-activating enzyme (AAE) consensus motif; other site 525897002616 AMP binding site [chemical binding]; other site 525897002617 active site 525897002618 CoA binding site [chemical binding]; other site 525897002619 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 525897002620 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 525897002621 phosphoglyceromutase; Provisional; Region: PRK05434 525897002622 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 525897002623 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 525897002624 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 525897002625 EamA-like transporter family; Region: EamA; pfam00892 525897002626 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525897002627 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525897002628 substrate binding pocket [chemical binding]; other site 525897002629 membrane-bound complex binding site; other site 525897002630 hinge residues; other site 525897002631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897002632 dimer interface [polypeptide binding]; other site 525897002633 conserved gate region; other site 525897002634 putative PBP binding loops; other site 525897002635 ABC-ATPase subunit interface; other site 525897002636 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525897002637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897002638 Walker A/P-loop; other site 525897002639 ATP binding site [chemical binding]; other site 525897002640 Q-loop/lid; other site 525897002641 ABC transporter signature motif; other site 525897002642 Walker B; other site 525897002643 D-loop; other site 525897002644 H-loop/switch region; other site 525897002645 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 525897002646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897002647 dimer interface [polypeptide binding]; other site 525897002648 conserved gate region; other site 525897002649 putative PBP binding loops; other site 525897002650 ABC-ATPase subunit interface; other site 525897002651 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 525897002652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897002653 Walker A/P-loop; other site 525897002654 ATP binding site [chemical binding]; other site 525897002655 Q-loop/lid; other site 525897002656 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525897002657 ABC transporter; Region: ABC_tran_2; pfam12848 525897002658 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525897002659 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 525897002660 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 525897002661 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525897002662 DNA-binding site [nucleotide binding]; DNA binding site 525897002663 UTRA domain; Region: UTRA; pfam07702 525897002664 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 525897002665 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 525897002666 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 525897002667 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 525897002668 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 525897002669 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525897002670 Walker A/P-loop; other site 525897002671 ATP binding site [chemical binding]; other site 525897002672 Q-loop/lid; other site 525897002673 ABC transporter signature motif; other site 525897002674 Walker B; other site 525897002675 D-loop; other site 525897002676 H-loop/switch region; other site 525897002677 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 525897002678 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 525897002679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897002680 Walker A/P-loop; other site 525897002681 ATP binding site [chemical binding]; other site 525897002682 Q-loop/lid; other site 525897002683 ABC transporter signature motif; other site 525897002684 Walker B; other site 525897002685 D-loop; other site 525897002686 H-loop/switch region; other site 525897002687 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 525897002688 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 525897002689 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 525897002690 active site 525897002691 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 525897002692 active site 525897002693 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 525897002694 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 525897002695 trimer interface [polypeptide binding]; other site 525897002696 active site 525897002697 substrate binding site [chemical binding]; other site 525897002698 CoA binding site [chemical binding]; other site 525897002699 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 525897002700 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 525897002701 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 525897002702 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 525897002703 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 525897002704 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 525897002705 active site 525897002706 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 525897002707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897002708 dimer interface [polypeptide binding]; other site 525897002709 conserved gate region; other site 525897002710 putative PBP binding loops; other site 525897002711 ABC-ATPase subunit interface; other site 525897002712 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 525897002713 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 525897002714 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 525897002715 Walker A/P-loop; other site 525897002716 ATP binding site [chemical binding]; other site 525897002717 Q-loop/lid; other site 525897002718 ABC transporter signature motif; other site 525897002719 Walker B; other site 525897002720 D-loop; other site 525897002721 H-loop/switch region; other site 525897002722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897002723 binding surface 525897002724 TPR motif; other site 525897002725 TPR repeat; Region: TPR_11; pfam13414 525897002726 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897002727 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897002728 putative active site [active] 525897002729 heme pocket [chemical binding]; other site 525897002730 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897002731 putative active site [active] 525897002732 heme pocket [chemical binding]; other site 525897002733 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 525897002734 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 525897002735 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897002736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897002737 dimer interface [polypeptide binding]; other site 525897002738 phosphorylation site [posttranslational modification] 525897002739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897002740 ATP binding site [chemical binding]; other site 525897002741 Mg2+ binding site [ion binding]; other site 525897002742 G-X-G motif; other site 525897002743 Response regulator receiver domain; Region: Response_reg; pfam00072 525897002744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897002745 active site 525897002746 phosphorylation site [posttranslational modification] 525897002747 intermolecular recognition site; other site 525897002748 dimerization interface [polypeptide binding]; other site 525897002749 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 525897002750 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 525897002751 active site 525897002752 catalytic residues [active] 525897002753 metal binding site [ion binding]; metal-binding site 525897002754 homomethionine N-hydroxylase; Region: PLN03018 525897002755 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 525897002756 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 525897002757 Nucleotide-binding sites [chemical binding]; other site 525897002758 Walker A motif; other site 525897002759 Switch I region of nucleotide binding site; other site 525897002760 Fe4S4 binding sites [ion binding]; other site 525897002761 Switch II region of nucleotide binding site; other site 525897002762 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 525897002763 Nitrogen regulatory protein P-II; Region: P-II; smart00938 525897002764 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 525897002765 Nitrogen regulatory protein P-II; Region: P-II; smart00938 525897002766 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 525897002767 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 525897002768 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 525897002769 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 525897002770 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 525897002771 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 525897002772 dimer interface [polypeptide binding]; other site 525897002773 [2Fe-2S] cluster binding site [ion binding]; other site 525897002774 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 525897002775 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 525897002776 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 525897002777 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 525897002778 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 525897002779 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897002780 FeS/SAM binding site; other site 525897002781 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 525897002782 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 525897002783 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 525897002784 PilZ domain; Region: PilZ; pfam07238 525897002785 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 525897002786 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 525897002787 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 525897002788 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897002789 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 525897002790 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 525897002791 Cysteine-rich domain; Region: CCG; pfam02754 525897002792 Cysteine-rich domain; Region: CCG; pfam02754 525897002793 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 525897002794 4Fe-4S binding domain; Region: Fer4; pfam00037 525897002795 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 525897002796 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897002797 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 525897002798 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 525897002799 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 525897002800 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 525897002801 FAD binding pocket [chemical binding]; other site 525897002802 FAD binding motif [chemical binding]; other site 525897002803 phosphate binding motif [ion binding]; other site 525897002804 beta-alpha-beta structure motif; other site 525897002805 NAD binding pocket [chemical binding]; other site 525897002806 Iron coordination center [ion binding]; other site 525897002807 Uncharacterized conserved protein [Function unknown]; Region: COG1633 525897002808 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 525897002809 diiron binding motif [ion binding]; other site 525897002810 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 525897002811 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525897002812 substrate binding pocket [chemical binding]; other site 525897002813 membrane-bound complex binding site; other site 525897002814 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 525897002815 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 525897002816 Walker A/P-loop; other site 525897002817 ATP binding site [chemical binding]; other site 525897002818 Q-loop/lid; other site 525897002819 ABC transporter signature motif; other site 525897002820 Walker B; other site 525897002821 D-loop; other site 525897002822 H-loop/switch region; other site 525897002823 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 525897002824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897002825 dimer interface [polypeptide binding]; other site 525897002826 conserved gate region; other site 525897002827 ABC-ATPase subunit interface; other site 525897002828 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 525897002829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897002830 dimer interface [polypeptide binding]; other site 525897002831 conserved gate region; other site 525897002832 ABC-ATPase subunit interface; other site 525897002833 Nuclease-related domain; Region: NERD; pfam08378 525897002834 Zn-ribbon containing protein [General function prediction only]; Region: COG3364 525897002835 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 525897002836 putative deacylase active site [active] 525897002837 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 525897002838 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 525897002839 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 525897002840 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 525897002841 putative GEF interaction site [polypeptide binding]; other site 525897002842 G1 box; other site 525897002843 GTP/Mg2+ binding site [chemical binding]; other site 525897002844 Switch I region; other site 525897002845 G2 box; other site 525897002846 G3 box; other site 525897002847 Switch II region; other site 525897002848 G4 box; other site 525897002849 G5 box; other site 525897002850 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 525897002851 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 525897002852 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 525897002853 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 525897002854 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897002855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897002856 active site 525897002857 phosphorylation site [posttranslational modification] 525897002858 intermolecular recognition site; other site 525897002859 dimerization interface [polypeptide binding]; other site 525897002860 PAS domain S-box; Region: sensory_box; TIGR00229 525897002861 PAS domain; Region: PAS; smart00091 525897002862 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897002863 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897002864 metal binding site [ion binding]; metal-binding site 525897002865 active site 525897002866 I-site; other site 525897002867 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 525897002868 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 525897002869 anti sigma factor interaction site; other site 525897002870 regulatory phosphorylation site [posttranslational modification]; other site 525897002871 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 525897002872 putative binding surface; other site 525897002873 active site 525897002874 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 525897002875 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 525897002876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897002877 ATP binding site [chemical binding]; other site 525897002878 Mg2+ binding site [ion binding]; other site 525897002879 G-X-G motif; other site 525897002880 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 525897002881 CheW-like domain; Region: CheW; pfam01584 525897002882 Response regulator receiver domain; Region: Response_reg; pfam00072 525897002883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897002884 active site 525897002885 phosphorylation site [posttranslational modification] 525897002886 intermolecular recognition site; other site 525897002887 dimerization interface [polypeptide binding]; other site 525897002888 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 525897002889 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 525897002890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897002891 active site 525897002892 phosphorylation site [posttranslational modification] 525897002893 intermolecular recognition site; other site 525897002894 dimerization interface [polypeptide binding]; other site 525897002895 CheB methylesterase; Region: CheB_methylest; pfam01339 525897002896 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 525897002897 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 525897002898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897002899 S-adenosylmethionine binding site [chemical binding]; other site 525897002900 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 525897002901 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 525897002902 pyruvate carboxylase; Reviewed; Region: PRK12999 525897002903 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 525897002904 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525897002905 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 525897002906 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 525897002907 active site 525897002908 catalytic residues [active] 525897002909 metal binding site [ion binding]; metal-binding site 525897002910 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 525897002911 carboxyltransferase (CT) interaction site; other site 525897002912 biotinylation site [posttranslational modification]; other site 525897002913 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 525897002914 Double zinc ribbon; Region: DZR; pfam12773 525897002915 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 525897002916 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 525897002917 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 525897002918 Protein of unknown function DUF45; Region: DUF45; pfam01863 525897002919 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 525897002920 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 525897002921 metal binding site [ion binding]; metal-binding site 525897002922 dimer interface [polypeptide binding]; other site 525897002923 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 525897002924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525897002925 Coenzyme A binding pocket [chemical binding]; other site 525897002926 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 525897002927 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 525897002928 Phosphoglycerate kinase; Region: PGK; pfam00162 525897002929 substrate binding site [chemical binding]; other site 525897002930 hinge regions; other site 525897002931 ADP binding site [chemical binding]; other site 525897002932 catalytic site [active] 525897002933 triosephosphate isomerase; Provisional; Region: PRK14567 525897002934 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 525897002935 substrate binding site [chemical binding]; other site 525897002936 dimer interface [polypeptide binding]; other site 525897002937 catalytic triad [active] 525897002938 Preprotein translocase SecG subunit; Region: SecG; pfam03840 525897002939 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525897002940 active site 525897002941 Int/Topo IB signature motif; other site 525897002942 DNA binding site [nucleotide binding] 525897002943 Helix-turn-helix domain; Region: HTH_36; pfam13730 525897002944 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 525897002945 multiple promoter invertase; Provisional; Region: mpi; PRK13413 525897002946 catalytic residues [active] 525897002947 catalytic nucleophile [active] 525897002948 Presynaptic Site I dimer interface [polypeptide binding]; other site 525897002949 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 525897002950 Synaptic Flat tetramer interface [polypeptide binding]; other site 525897002951 Synaptic Site I dimer interface [polypeptide binding]; other site 525897002952 DNA binding site [nucleotide binding] 525897002953 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 525897002954 DNA-binding interface [nucleotide binding]; DNA binding site 525897002955 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 525897002956 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525897002957 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 525897002958 active site 525897002959 DNA binding site [nucleotide binding] 525897002960 Int/Topo IB signature motif; other site 525897002961 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 525897002962 additional DNA contacts [nucleotide binding]; other site 525897002963 mismatch recognition site; other site 525897002964 active site 525897002965 zinc binding site [ion binding]; other site 525897002966 DNA intercalation site [nucleotide binding]; other site 525897002967 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 525897002968 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 525897002969 cofactor binding site; other site 525897002970 DNA binding site [nucleotide binding] 525897002971 substrate interaction site [chemical binding]; other site 525897002972 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 525897002973 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 525897002974 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 525897002975 catalytic residues [active] 525897002976 catalytic nucleophile [active] 525897002977 Recombinase; Region: Recombinase; pfam07508 525897002978 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 525897002979 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 525897002980 Prophage antirepressor [Transcription]; Region: COG3617 525897002981 BRO family, N-terminal domain; Region: Bro-N; smart01040 525897002982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897002983 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 525897002984 Domain of unknown function DUF20; Region: UPF0118; pfam01594 525897002985 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 525897002986 Domain of unknown function DUF21; Region: DUF21; pfam01595 525897002987 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 525897002988 Transporter associated domain; Region: CorC_HlyC; smart01091 525897002989 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525897002990 putative Zn2+ binding site [ion binding]; other site 525897002991 putative DNA binding site [nucleotide binding]; other site 525897002992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525897002993 putative substrate translocation pore; other site 525897002994 Protein of unknown function (DUF533); Region: DUF533; pfam04391 525897002995 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 525897002996 putative metal binding site [ion binding]; other site 525897002997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897002998 S-adenosylmethionine binding site [chemical binding]; other site 525897002999 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 525897003000 PLD-like domain; Region: PLDc_2; pfam13091 525897003001 putative homodimer interface [polypeptide binding]; other site 525897003002 putative active site [active] 525897003003 catalytic site [active] 525897003004 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 525897003005 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525897003006 ATP binding site [chemical binding]; other site 525897003007 putative Mg++ binding site [ion binding]; other site 525897003008 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525897003009 nucleotide binding region [chemical binding]; other site 525897003010 ATP-binding site [chemical binding]; other site 525897003011 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 525897003012 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 525897003013 active site 525897003014 8-oxo-dGMP binding site [chemical binding]; other site 525897003015 nudix motif; other site 525897003016 metal binding site [ion binding]; metal-binding site 525897003017 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 525897003018 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 525897003019 active site 525897003020 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 525897003021 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 525897003022 Response regulator receiver domain; Region: Response_reg; pfam00072 525897003023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897003024 active site 525897003025 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897003026 phosphorylation site [posttranslational modification] 525897003027 intermolecular recognition site; other site 525897003028 dimerization interface [polypeptide binding]; other site 525897003029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897003030 dimer interface [polypeptide binding]; other site 525897003031 phosphorylation site [posttranslational modification] 525897003032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897003033 ATP binding site [chemical binding]; other site 525897003034 Mg2+ binding site [ion binding]; other site 525897003035 G-X-G motif; other site 525897003036 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897003037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897003038 active site 525897003039 intermolecular recognition site; other site 525897003040 dimerization interface [polypeptide binding]; other site 525897003041 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 525897003042 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 525897003043 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 525897003044 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 525897003045 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 525897003046 Protein of unknown function (DUF493); Region: DUF493; pfam04359 525897003047 Major Facilitator Superfamily; Region: MFS_1; pfam07690 525897003048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525897003049 putative substrate translocation pore; other site 525897003050 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 525897003051 Sodium Bile acid symporter family; Region: SBF; cl17470 525897003052 PilZ domain; Region: PilZ; cl01260 525897003053 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 525897003054 NMT1/THI5 like; Region: NMT1; pfam09084 525897003055 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 525897003056 membrane-bound complex binding site; other site 525897003057 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 525897003058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897003059 dimer interface [polypeptide binding]; other site 525897003060 conserved gate region; other site 525897003061 putative PBP binding loops; other site 525897003062 ABC-ATPase subunit interface; other site 525897003063 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 525897003064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897003065 Walker A/P-loop; other site 525897003066 ATP binding site [chemical binding]; other site 525897003067 Q-loop/lid; other site 525897003068 ABC transporter signature motif; other site 525897003069 Walker B; other site 525897003070 D-loop; other site 525897003071 H-loop/switch region; other site 525897003072 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 525897003073 dimer interface [polypeptide binding]; other site 525897003074 substrate binding site [chemical binding]; other site 525897003075 ATP binding site [chemical binding]; other site 525897003076 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 525897003077 thiamine phosphate binding site [chemical binding]; other site 525897003078 active site 525897003079 pyrophosphate binding site [ion binding]; other site 525897003080 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 525897003081 substrate binding site [chemical binding]; other site 525897003082 multimerization interface [polypeptide binding]; other site 525897003083 ATP binding site [chemical binding]; other site 525897003084 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 525897003085 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 525897003086 Active Sites [active] 525897003087 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 525897003088 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 525897003089 ligand binding site [chemical binding]; other site 525897003090 flexible hinge region; other site 525897003091 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 525897003092 putative switch regulator; other site 525897003093 non-specific DNA interactions [nucleotide binding]; other site 525897003094 DNA binding site [nucleotide binding] 525897003095 sequence specific DNA binding site [nucleotide binding]; other site 525897003096 putative cAMP binding site [chemical binding]; other site 525897003097 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 525897003098 P-loop; other site 525897003099 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525897003100 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 525897003101 ACS interaction site; other site 525897003102 CODH interaction site; other site 525897003103 Prismane/CO dehydrogenase family; Region: Prismane; pfam03063 525897003104 cubane metal cluster (B-cluster) [ion binding]; other site 525897003105 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 525897003106 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 525897003107 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 525897003108 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 525897003109 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 525897003110 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 525897003111 prolyl-tRNA synthetase; Provisional; Region: PRK09194 525897003112 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 525897003113 dimer interface [polypeptide binding]; other site 525897003114 motif 1; other site 525897003115 active site 525897003116 motif 2; other site 525897003117 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 525897003118 putative deacylase active site [active] 525897003119 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 525897003120 active site 525897003121 motif 3; other site 525897003122 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 525897003123 anticodon binding site; other site 525897003124 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 525897003125 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 525897003126 generic binding surface II; other site 525897003127 generic binding surface I; other site 525897003128 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 525897003129 Peptidase family M23; Region: Peptidase_M23; pfam01551 525897003130 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 525897003131 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 525897003132 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 525897003133 substrate binding pocket [chemical binding]; other site 525897003134 chain length determination region; other site 525897003135 substrate-Mg2+ binding site; other site 525897003136 catalytic residues [active] 525897003137 aspartate-rich region 1; other site 525897003138 active site lid residues [active] 525897003139 aspartate-rich region 2; other site 525897003140 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 525897003141 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 525897003142 TPP-binding site; other site 525897003143 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 525897003144 PYR/PP interface [polypeptide binding]; other site 525897003145 dimer interface [polypeptide binding]; other site 525897003146 TPP binding site [chemical binding]; other site 525897003147 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 525897003148 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 525897003149 core domain interface [polypeptide binding]; other site 525897003150 delta subunit interface [polypeptide binding]; other site 525897003151 epsilon subunit interface [polypeptide binding]; other site 525897003152 alternate F1F0 ATPase, F1 subunit alpha; Region: alt_F1F0_F1_al; TIGR03324 525897003153 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 525897003154 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 525897003155 beta subunit interaction interface [polypeptide binding]; other site 525897003156 Walker A motif; other site 525897003157 ATP binding site [chemical binding]; other site 525897003158 Walker B motif; other site 525897003159 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 525897003160 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 525897003161 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 525897003162 alternate F1F0 ATPase, F0 subunit C; Region: alt_F1F0_F0_C; TIGR03322 525897003163 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 525897003164 alternate F1F0 ATPase, F0 subunit A; Region: altF1_A; TIGR03306 525897003165 N-ATPase, AtpR subunit; Region: AtpR; pfam12966 525897003166 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 525897003167 F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228 525897003168 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 525897003169 gamma subunit interface [polypeptide binding]; other site 525897003170 epsilon subunit interface [polypeptide binding]; other site 525897003171 LBP interface [polypeptide binding]; other site 525897003172 alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305 525897003173 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 525897003174 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 525897003175 alpha subunit interaction interface [polypeptide binding]; other site 525897003176 Walker A motif; other site 525897003177 ATP binding site [chemical binding]; other site 525897003178 Walker B motif; other site 525897003179 inhibitor binding site; inhibition site 525897003180 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 525897003181 Predicted membrane protein [Function unknown]; Region: COG4325 525897003182 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 525897003183 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525897003184 Ligand Binding Site [chemical binding]; other site 525897003185 Pirin-related protein [General function prediction only]; Region: COG1741 525897003186 Pirin; Region: Pirin; pfam02678 525897003187 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 525897003188 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525897003189 active site residue [active] 525897003190 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525897003191 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 525897003192 active site 525897003193 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 525897003194 active site 1 [active] 525897003195 dimer interface [polypeptide binding]; other site 525897003196 hexamer interface [polypeptide binding]; other site 525897003197 active site 2 [active] 525897003198 Cupin domain; Region: Cupin_2; cl17218 525897003199 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 525897003200 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 525897003201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897003202 catalytic residue [active] 525897003203 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 525897003204 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 525897003205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897003206 dimer interface [polypeptide binding]; other site 525897003207 phosphorylation site [posttranslational modification] 525897003208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897003209 ATP binding site [chemical binding]; other site 525897003210 Mg2+ binding site [ion binding]; other site 525897003211 G-X-G motif; other site 525897003212 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897003213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 525897003214 active site 525897003215 phosphorylation site [posttranslational modification] 525897003216 intermolecular recognition site; other site 525897003217 dimerization interface [polypeptide binding]; other site 525897003218 Response regulator receiver domain; Region: Response_reg; pfam00072 525897003219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897003220 active site 525897003221 phosphorylation site [posttranslational modification] 525897003222 intermolecular recognition site; other site 525897003223 dimerization interface [polypeptide binding]; other site 525897003224 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 525897003225 Precorrin-8X methylmutase; Region: CbiC; pfam02570 525897003226 Uncharacterized conserved protein [Function unknown]; Region: COG1359 525897003227 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 525897003228 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 525897003229 metal-binding site [ion binding] 525897003230 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 525897003231 active site 525897003232 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 525897003233 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 525897003234 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 525897003235 [4Fe-4S] binding site [ion binding]; other site 525897003236 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525897003237 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525897003238 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 525897003239 molybdopterin cofactor binding site; other site 525897003240 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 525897003241 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 525897003242 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 525897003243 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 525897003244 putative ligand binding site [chemical binding]; other site 525897003245 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 525897003246 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897003247 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897003248 putative active site [active] 525897003249 heme pocket [chemical binding]; other site 525897003250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897003251 dimer interface [polypeptide binding]; other site 525897003252 phosphorylation site [posttranslational modification] 525897003253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897003254 ATP binding site [chemical binding]; other site 525897003255 Mg2+ binding site [ion binding]; other site 525897003256 G-X-G motif; other site 525897003257 Response regulator receiver domain; Region: Response_reg; pfam00072 525897003258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897003259 active site 525897003260 phosphorylation site [posttranslational modification] 525897003261 intermolecular recognition site; other site 525897003262 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 525897003263 dimerization interface [polypeptide binding]; other site 525897003264 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 525897003265 anti sigma factor interaction site; other site 525897003266 regulatory phosphorylation site [posttranslational modification]; other site 525897003267 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 525897003268 catalytic residues [active] 525897003269 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525897003270 active site residue [active] 525897003271 Methylamine utilisation protein MauE; Region: MauE; pfam07291 525897003272 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 525897003273 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 525897003274 GTP binding site; other site 525897003275 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 525897003276 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 525897003277 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 525897003278 Transcriptional regulator [Transcription]; Region: LysR; COG0583 525897003279 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 525897003280 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 525897003281 dimer interface [polypeptide binding]; other site 525897003282 putative functional site; other site 525897003283 putative MPT binding site; other site 525897003284 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 525897003285 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 525897003286 dimer interface [polypeptide binding]; other site 525897003287 putative functional site; other site 525897003288 putative MPT binding site; other site 525897003289 PBP superfamily domain; Region: PBP_like; pfam12727 525897003290 YHS domain; Region: YHS; pfam04945 525897003291 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 525897003292 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525897003293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525897003294 motif II; other site 525897003295 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 525897003296 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 525897003297 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525897003298 ATP binding site [chemical binding]; other site 525897003299 putative Mg++ binding site [ion binding]; other site 525897003300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525897003301 nucleotide binding region [chemical binding]; other site 525897003302 ATP-binding site [chemical binding]; other site 525897003303 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 525897003304 SurA N-terminal domain; Region: SurA_N_3; cl07813 525897003305 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 525897003306 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 525897003307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525897003308 non-specific DNA binding site [nucleotide binding]; other site 525897003309 salt bridge; other site 525897003310 sequence-specific DNA binding site [nucleotide binding]; other site 525897003311 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 525897003312 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 525897003313 Recombination protein O N terminal; Region: RecO_N; pfam11967 525897003314 Recombination protein O C terminal; Region: RecO_C; pfam02565 525897003315 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 525897003316 dimer interface [polypeptide binding]; other site 525897003317 motif 1; other site 525897003318 active site 525897003319 motif 2; other site 525897003320 motif 3; other site 525897003321 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 525897003322 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 525897003323 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 525897003324 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 525897003325 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 525897003326 putative ligand binding site [chemical binding]; other site 525897003327 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 525897003328 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525897003329 TM-ABC transporter signature motif; other site 525897003330 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 525897003331 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 525897003332 TM-ABC transporter signature motif; other site 525897003333 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 525897003334 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 525897003335 Walker A/P-loop; other site 525897003336 ATP binding site [chemical binding]; other site 525897003337 Q-loop/lid; other site 525897003338 ABC transporter signature motif; other site 525897003339 Walker B; other site 525897003340 D-loop; other site 525897003341 H-loop/switch region; other site 525897003342 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 525897003343 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 525897003344 Walker A/P-loop; other site 525897003345 ATP binding site [chemical binding]; other site 525897003346 Q-loop/lid; other site 525897003347 ABC transporter signature motif; other site 525897003348 Walker B; other site 525897003349 D-loop; other site 525897003350 H-loop/switch region; other site 525897003351 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 525897003352 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525897003353 acyl-activating enzyme (AAE) consensus motif; other site 525897003354 AMP binding site [chemical binding]; other site 525897003355 active site 525897003356 CoA binding site [chemical binding]; other site 525897003357 BRO family, N-terminal domain; Region: Bro-N; smart01040 525897003358 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 525897003359 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 525897003360 amphi-Trp domain; Region: amphi-Trp; TIGR04354 525897003361 VacJ like lipoprotein; Region: VacJ; cl01073 525897003362 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 525897003363 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 525897003364 mce related protein; Region: MCE; pfam02470 525897003365 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 525897003366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897003367 Walker A/P-loop; other site 525897003368 ATP binding site [chemical binding]; other site 525897003369 Q-loop/lid; other site 525897003370 ABC transporter signature motif; other site 525897003371 Walker B; other site 525897003372 D-loop; other site 525897003373 H-loop/switch region; other site 525897003374 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 525897003375 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 525897003376 Permease; Region: Permease; pfam02405 525897003377 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 525897003378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 525897003379 active site 525897003380 motif I; other site 525897003381 motif II; other site 525897003382 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 525897003383 dimer interface [polypeptide binding]; other site 525897003384 pyridoxal binding site [chemical binding]; other site 525897003385 ATP binding site [chemical binding]; other site 525897003386 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 525897003387 IHF - DNA interface [nucleotide binding]; other site 525897003388 IHF dimer interface [polypeptide binding]; other site 525897003389 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 525897003390 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 525897003391 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 525897003392 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 525897003393 dimer interface [polypeptide binding]; other site 525897003394 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 525897003395 homodimer interface [polypeptide binding]; other site 525897003396 metal binding site [ion binding]; metal-binding site 525897003397 sensor protein ZraS; Provisional; Region: PRK10364 525897003398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897003399 phosphorylation site [posttranslational modification] 525897003400 dimer interface [polypeptide binding]; other site 525897003401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897003402 ATP binding site [chemical binding]; other site 525897003403 Mg2+ binding site [ion binding]; other site 525897003404 G-X-G motif; other site 525897003405 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897003406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897003407 active site 525897003408 phosphorylation site [posttranslational modification] 525897003409 intermolecular recognition site; other site 525897003410 dimerization interface [polypeptide binding]; other site 525897003411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897003412 Walker A motif; other site 525897003413 ATP binding site [chemical binding]; other site 525897003414 Walker B motif; other site 525897003415 arginine finger; other site 525897003416 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897003417 Predicted amidohydrolase [General function prediction only]; Region: COG0388 525897003418 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 525897003419 active site 525897003420 catalytic triad [active] 525897003421 dimer interface [polypeptide binding]; other site 525897003422 Protein of unknown function, DUF485; Region: DUF485; pfam04341 525897003423 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 525897003424 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 525897003425 Na binding site [ion binding]; other site 525897003426 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 525897003427 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 525897003428 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 525897003429 metal binding triad; other site 525897003430 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525897003431 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897003432 Cysteine-rich domain; Region: CCG; pfam02754 525897003433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525897003434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525897003435 putative transposase OrfB; Reviewed; Region: PHA02517 525897003436 HTH-like domain; Region: HTH_21; pfam13276 525897003437 Integrase core domain; Region: rve; pfam00665 525897003438 Integrase core domain; Region: rve_3; pfam13683 525897003439 Transposase; Region: HTH_Tnp_1; pfam01527 525897003440 Transposase; Region: DEDD_Tnp_IS110; pfam01548 525897003441 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897003442 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897003443 phosphorylation site [posttranslational modification] 525897003444 dimer interface [polypeptide binding]; other site 525897003445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897003446 ATP binding site [chemical binding]; other site 525897003447 Mg2+ binding site [ion binding]; other site 525897003448 G-X-G motif; other site 525897003449 PAS domain S-box; Region: sensory_box; TIGR00229 525897003450 PAS domain S-box; Region: sensory_box; TIGR00229 525897003451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897003452 putative active site [active] 525897003453 heme pocket [chemical binding]; other site 525897003454 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525897003455 DNA binding residues [nucleotide binding] 525897003456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 525897003457 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 525897003458 DnaA box-binding interface [nucleotide binding]; other site 525897003459 periplasmic protein; Provisional; Region: PRK10568 525897003460 BON domain; Region: BON; pfam04972 525897003461 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 525897003462 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897003463 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897003464 putative active site [active] 525897003465 heme pocket [chemical binding]; other site 525897003466 PAS domain S-box; Region: sensory_box; TIGR00229 525897003467 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897003468 putative active site [active] 525897003469 heme pocket [chemical binding]; other site 525897003470 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897003471 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897003472 metal binding site [ion binding]; metal-binding site 525897003473 active site 525897003474 I-site; other site 525897003475 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 525897003476 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 525897003477 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 525897003478 dimer interface [polypeptide binding]; other site 525897003479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897003480 catalytic residue [active] 525897003481 Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215 525897003482 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 525897003483 Response regulator receiver domain; Region: Response_reg; pfam00072 525897003484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897003485 active site 525897003486 phosphorylation site [posttranslational modification] 525897003487 intermolecular recognition site; other site 525897003488 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 525897003489 putative binding surface; other site 525897003490 active site 525897003491 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525897003492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897003493 active site 525897003494 phosphorylation site [posttranslational modification] 525897003495 intermolecular recognition site; other site 525897003496 dimerization interface [polypeptide binding]; other site 525897003497 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525897003498 DNA binding residues [nucleotide binding] 525897003499 dimerization interface [polypeptide binding]; other site 525897003500 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 525897003501 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 525897003502 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525897003503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897003504 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897003505 putative active site [active] 525897003506 heme pocket [chemical binding]; other site 525897003507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897003508 putative active site [active] 525897003509 heme pocket [chemical binding]; other site 525897003510 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897003511 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897003512 putative active site [active] 525897003513 heme pocket [chemical binding]; other site 525897003514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897003515 dimer interface [polypeptide binding]; other site 525897003516 phosphorylation site [posttranslational modification] 525897003517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897003518 ATP binding site [chemical binding]; other site 525897003519 Mg2+ binding site [ion binding]; other site 525897003520 G-X-G motif; other site 525897003521 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897003522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897003523 active site 525897003524 phosphorylation site [posttranslational modification] 525897003525 intermolecular recognition site; other site 525897003526 dimerization interface [polypeptide binding]; other site 525897003527 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897003528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897003529 active site 525897003530 phosphorylation site [posttranslational modification] 525897003531 intermolecular recognition site; other site 525897003532 dimerization interface [polypeptide binding]; other site 525897003533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897003534 Walker A motif; other site 525897003535 ATP binding site [chemical binding]; other site 525897003536 Walker B motif; other site 525897003537 arginine finger; other site 525897003538 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 525897003539 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 525897003540 dimer interface [polypeptide binding]; other site 525897003541 PYR/PP interface [polypeptide binding]; other site 525897003542 TPP binding site [chemical binding]; other site 525897003543 substrate binding site [chemical binding]; other site 525897003544 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 525897003545 Domain of unknown function; Region: EKR; pfam10371 525897003546 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897003547 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 525897003548 TPP-binding site [chemical binding]; other site 525897003549 dimer interface [polypeptide binding]; other site 525897003550 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 525897003551 L-lactate permease; Region: Lactate_perm; cl00701 525897003552 FAD binding domain; Region: FAD_binding_4; pfam01565 525897003553 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 525897003554 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897003555 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525897003556 Cysteine-rich domain; Region: CCG; pfam02754 525897003557 Cysteine-rich domain; Region: CCG; pfam02754 525897003558 phosphate acetyltransferase; Reviewed; Region: PRK05632 525897003559 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525897003560 DRTGG domain; Region: DRTGG; pfam07085 525897003561 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 525897003562 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 525897003563 propionate/acetate kinase; Provisional; Region: PRK12379 525897003564 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 525897003565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 525897003566 PAS domain S-box; Region: sensory_box; TIGR00229 525897003567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897003568 putative active site [active] 525897003569 heme pocket [chemical binding]; other site 525897003570 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 525897003571 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897003572 putative active site [active] 525897003573 heme pocket [chemical binding]; other site 525897003574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897003575 dimer interface [polypeptide binding]; other site 525897003576 phosphorylation site [posttranslational modification] 525897003577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897003578 ATP binding site [chemical binding]; other site 525897003579 Mg2+ binding site [ion binding]; other site 525897003580 G-X-G motif; other site 525897003581 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897003582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897003583 active site 525897003584 phosphorylation site [posttranslational modification] 525897003585 intermolecular recognition site; other site 525897003586 dimerization interface [polypeptide binding]; other site 525897003587 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 525897003588 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 525897003589 active site 525897003590 metal binding site [ion binding]; metal-binding site 525897003591 DNA binding site [nucleotide binding] 525897003592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897003593 AAA domain; Region: AAA_27; pfam13514 525897003594 Walker A/P-loop; other site 525897003595 ATP binding site [chemical binding]; other site 525897003596 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 525897003597 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897003598 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 525897003599 FtsX-like permease family; Region: FtsX; pfam02687 525897003600 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525897003601 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525897003602 Walker A/P-loop; other site 525897003603 ATP binding site [chemical binding]; other site 525897003604 Q-loop/lid; other site 525897003605 ABC transporter signature motif; other site 525897003606 Walker B; other site 525897003607 D-loop; other site 525897003608 H-loop/switch region; other site 525897003609 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525897003610 heme-binding residues [chemical binding]; other site 525897003611 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 525897003612 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525897003613 active site residue [active] 525897003614 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 525897003615 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 525897003616 CPxP motif; other site 525897003617 DsrE/DsrF-like family; Region: DrsE; pfam02635 525897003618 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 525897003619 putative acyl-acceptor binding pocket; other site 525897003620 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 525897003621 putative acyl-acceptor binding pocket; other site 525897003622 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 525897003623 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 525897003624 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 525897003625 active site 525897003626 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 525897003627 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 525897003628 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897003629 dimerization interface [polypeptide binding]; other site 525897003630 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525897003631 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897003632 dimer interface [polypeptide binding]; other site 525897003633 putative CheW interface [polypeptide binding]; other site 525897003634 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 525897003635 Predicted transcriptional regulator [Transcription]; Region: COG2932 525897003636 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 525897003637 Catalytic site [active] 525897003638 RmuC family; Region: RmuC; pfam02646 525897003639 Methyltransferase domain; Region: Methyltransf_23; pfam13489 525897003640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897003641 S-adenosylmethionine binding site [chemical binding]; other site 525897003642 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 525897003643 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 525897003644 dimer interface [polypeptide binding]; other site 525897003645 active site 525897003646 heme binding site [chemical binding]; other site 525897003647 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 525897003648 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 525897003649 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 525897003650 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525897003651 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 525897003652 Soluble P-type ATPase [General function prediction only]; Region: COG4087 525897003653 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 525897003654 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 525897003655 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897003656 PAS fold; Region: PAS_3; pfam08447 525897003657 putative active site [active] 525897003658 heme pocket [chemical binding]; other site 525897003659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897003660 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525897003661 Walker A motif; other site 525897003662 ATP binding site [chemical binding]; other site 525897003663 Walker B motif; other site 525897003664 arginine finger; other site 525897003665 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897003666 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 525897003667 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 525897003668 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 525897003669 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 525897003670 Uncharacterized conserved protein [Function unknown]; Region: COG5361 525897003671 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 525897003672 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 525897003673 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897003674 FeS/SAM binding site; other site 525897003675 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 525897003676 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 525897003677 Sulfatase; Region: Sulfatase; pfam00884 525897003678 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 525897003679 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 525897003680 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 525897003681 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 525897003682 metal ion-dependent adhesion site (MIDAS); other site 525897003683 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 525897003684 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 525897003685 ligand binding site [chemical binding]; other site 525897003686 GAF domain; Region: GAF; pfam01590 525897003687 PAS domain S-box; Region: sensory_box; TIGR00229 525897003688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897003689 putative active site [active] 525897003690 heme pocket [chemical binding]; other site 525897003691 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 525897003692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897003693 Walker A motif; other site 525897003694 ATP binding site [chemical binding]; other site 525897003695 Walker B motif; other site 525897003696 arginine finger; other site 525897003697 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897003698 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 525897003699 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 525897003700 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 525897003701 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 525897003702 active site 525897003703 HslU subunit interaction site [polypeptide binding]; other site 525897003704 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 525897003705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897003706 Walker A motif; other site 525897003707 ATP binding site [chemical binding]; other site 525897003708 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 525897003709 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 525897003710 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 525897003711 homohexameric interface [polypeptide binding]; other site 525897003712 carbamate kinase; Reviewed; Region: PRK12686 525897003713 nucleotide binding site [chemical binding]; other site 525897003714 N-acetyl-L-glutamate binding site [chemical binding]; other site 525897003715 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 525897003716 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 525897003717 HDOD domain; Region: HDOD; pfam08668 525897003718 HD domain; Region: HD; pfam01966 525897003719 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 525897003720 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525897003721 catalytic residue [active] 525897003722 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 525897003723 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 525897003724 tetramer interface [polypeptide binding]; other site 525897003725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897003726 catalytic residue [active] 525897003727 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 525897003728 lipoyl attachment site [posttranslational modification]; other site 525897003729 Uncharacterized conserved protein [Function unknown]; Region: COG0398 525897003730 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 525897003731 Response regulator receiver domain; Region: Response_reg; pfam00072 525897003732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897003733 active site 525897003734 phosphorylation site [posttranslational modification] 525897003735 intermolecular recognition site; other site 525897003736 dimerization interface [polypeptide binding]; other site 525897003737 Phosphotransferase enzyme family; Region: APH; pfam01636 525897003738 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 525897003739 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 525897003740 Putative addiction module component; Region: Unstab_antitox; pfam09720 525897003741 uracil transporter; Provisional; Region: PRK10720 525897003742 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 525897003743 active site 525897003744 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 525897003745 AAA domain; Region: AAA_26; pfam13500 525897003746 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 525897003747 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 525897003748 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525897003749 catalytic residue [active] 525897003750 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 525897003751 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 525897003752 dimer interface [polypeptide binding]; other site 525897003753 active site 525897003754 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 525897003755 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 525897003756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525897003757 NAD(P) binding site [chemical binding]; other site 525897003758 active site 525897003759 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 525897003760 active site 1 [active] 525897003761 biotin synthase; Region: bioB; TIGR00433 525897003762 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897003763 FeS/SAM binding site; other site 525897003764 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 525897003765 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 525897003766 MgtE intracellular N domain; Region: MgtE_N; smart00924 525897003767 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 525897003768 Divalent cation transporter; Region: MgtE; pfam01769 525897003769 FOG: CBS domain [General function prediction only]; Region: COG0517 525897003770 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 525897003771 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 525897003772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897003773 S-adenosylmethionine binding site [chemical binding]; other site 525897003774 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 525897003775 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 525897003776 Walker A motif; other site 525897003777 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 525897003778 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 525897003779 N-acetyl-D-glucosamine binding site [chemical binding]; other site 525897003780 catalytic residue [active] 525897003781 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 525897003782 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 525897003783 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 525897003784 Walker A motif; other site 525897003785 ATP binding site [chemical binding]; other site 525897003786 Walker B motif; other site 525897003787 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 525897003788 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 525897003789 Walker A motif; other site 525897003790 ATP binding site [chemical binding]; other site 525897003791 Walker B motif; other site 525897003792 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 525897003793 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 525897003794 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 525897003795 AMP binding site [chemical binding]; other site 525897003796 metal binding site [ion binding]; metal-binding site 525897003797 active site 525897003798 UGMP family protein; Validated; Region: PRK09604 525897003799 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 525897003800 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 525897003801 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 525897003802 catalytic residues [active] 525897003803 Tetratricopeptide repeat; Region: TPR_18; pfam13512 525897003804 4Fe-4S binding domain; Region: Fer4_6; pfam12837 525897003805 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897003806 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 525897003807 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897003808 dimerization interface [polypeptide binding]; other site 525897003809 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897003810 dimer interface [polypeptide binding]; other site 525897003811 putative CheW interface [polypeptide binding]; other site 525897003812 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 525897003813 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 525897003814 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 525897003815 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 525897003816 dimer interface [polypeptide binding]; other site 525897003817 decamer (pentamer of dimers) interface [polypeptide binding]; other site 525897003818 catalytic triad [active] 525897003819 peroxidatic and resolving cysteines [active] 525897003820 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 525897003821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525897003822 motif II; other site 525897003823 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 525897003824 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 525897003825 active site 525897003826 Zn binding site [ion binding]; other site 525897003827 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 525897003828 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 525897003829 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 525897003830 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 525897003831 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525897003832 catalytic residue [active] 525897003833 Cache domain; Region: Cache_1; pfam02743 525897003834 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897003835 dimerization interface [polypeptide binding]; other site 525897003836 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525897003837 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897003838 dimer interface [polypeptide binding]; other site 525897003839 putative CheW interface [polypeptide binding]; other site 525897003840 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897003841 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897003842 metal binding site [ion binding]; metal-binding site 525897003843 active site 525897003844 I-site; other site 525897003845 intracellular protease, PfpI family; Region: PfpI; TIGR01382 525897003846 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 525897003847 conserved cys residue [active] 525897003848 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 525897003849 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 525897003850 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525897003851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525897003852 non-specific DNA binding site [nucleotide binding]; other site 525897003853 salt bridge; other site 525897003854 sequence-specific DNA binding site [nucleotide binding]; other site 525897003855 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897003856 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897003857 putative active site [active] 525897003858 heme pocket [chemical binding]; other site 525897003859 PAS fold; Region: PAS_4; pfam08448 525897003860 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897003861 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897003862 dimer interface [polypeptide binding]; other site 525897003863 phosphorylation site [posttranslational modification] 525897003864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897003865 ATP binding site [chemical binding]; other site 525897003866 Mg2+ binding site [ion binding]; other site 525897003867 G-X-G motif; other site 525897003868 Response regulator receiver domain; Region: Response_reg; pfam00072 525897003869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897003870 active site 525897003871 phosphorylation site [posttranslational modification] 525897003872 intermolecular recognition site; other site 525897003873 dimerization interface [polypeptide binding]; other site 525897003874 Sulfatase; Region: Sulfatase; cl17466 525897003875 putative transposase OrfB; Reviewed; Region: PHA02517 525897003876 HTH-like domain; Region: HTH_21; pfam13276 525897003877 Integrase core domain; Region: rve; pfam00665 525897003878 Integrase core domain; Region: rve_3; pfam13683 525897003879 Transposase; Region: HTH_Tnp_1; pfam01527 525897003880 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 525897003881 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 525897003882 putative active site [active] 525897003883 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 525897003884 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 525897003885 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 525897003886 B12 binding site [chemical binding]; other site 525897003887 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897003888 FeS/SAM binding site; other site 525897003889 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 525897003890 Uncharacterized conserved protein [Function unknown]; Region: COG2006 525897003891 Domain of unknown function (DUF362); Region: DUF362; pfam04015 525897003892 4Fe-4S binding domain; Region: Fer4_5; pfam12801 525897003893 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 525897003894 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897003895 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 525897003896 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897003897 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 525897003898 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 525897003899 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 525897003900 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 525897003901 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 525897003902 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 525897003903 Hemerythrin-like domain; Region: Hr-like; cd12108 525897003904 Fe binding site [ion binding]; other site 525897003905 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525897003906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897003907 Walker A/P-loop; other site 525897003908 ATP binding site [chemical binding]; other site 525897003909 Q-loop/lid; other site 525897003910 ABC transporter signature motif; other site 525897003911 Walker B; other site 525897003912 D-loop; other site 525897003913 H-loop/switch region; other site 525897003914 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 525897003915 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 525897003916 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 525897003917 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525897003918 active site residue [active] 525897003919 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525897003920 active site residue [active] 525897003921 Sulphur transport; Region: Sulf_transp; pfam04143 525897003922 Domain of unknown function (DUF305); Region: DUF305; cl17794 525897003923 Sulphur oxygenase reductase; Region: SOR; pfam07682 525897003924 myosin-cross-reactive antigen; Provisional; Region: PRK13977 525897003925 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 525897003926 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 525897003927 active site 525897003928 metal binding site [ion binding]; metal-binding site 525897003929 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 525897003930 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 525897003931 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 525897003932 potential catalytic triad [active] 525897003933 conserved cys residue [active] 525897003934 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525897003935 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 525897003936 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 525897003937 active site 525897003938 metal binding site [ion binding]; metal-binding site 525897003939 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 525897003940 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 525897003941 transmembrane helices; other site 525897003942 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 525897003943 TrkA-C domain; Region: TrkA_C; pfam02080 525897003944 TrkA-C domain; Region: TrkA_C; pfam02080 525897003945 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 525897003946 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 525897003947 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 525897003948 putative active site [active] 525897003949 catalytic site [active] 525897003950 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 525897003951 PLD-like domain; Region: PLDc_2; pfam13091 525897003952 putative active site [active] 525897003953 catalytic site [active] 525897003954 hydroperoxidase II; Provisional; Region: katE; PRK11249 525897003955 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 525897003956 tetramer interface [polypeptide binding]; other site 525897003957 heme binding pocket [chemical binding]; other site 525897003958 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 525897003959 domain interactions; other site 525897003960 Hemerythrin-like domain; Region: Hr-like; cd12108 525897003961 Fe binding site [ion binding]; other site 525897003962 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 525897003963 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 525897003964 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 525897003965 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 525897003966 [2Fe-2S] cluster binding site [ion binding]; other site 525897003967 Uncharacterized conserved protein [Function unknown]; Region: COG0398 525897003968 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 525897003969 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 525897003970 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 525897003971 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 525897003972 putative ADP-binding pocket [chemical binding]; other site 525897003973 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 525897003974 putative catalytic site [active] 525897003975 putative metal binding site [ion binding]; other site 525897003976 putative phosphate binding site [ion binding]; other site 525897003977 BON domain; Region: BON; pfam04972 525897003978 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 525897003979 Mechanosensitive ion channel; Region: MS_channel; pfam00924 525897003980 Predicted membrane protein [Function unknown]; Region: COG4325 525897003981 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 525897003982 BON domain; Region: BON; pfam04972 525897003983 Ion channel; Region: Ion_trans_2; pfam07885 525897003984 PAS domain S-box; Region: sensory_box; TIGR00229 525897003985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897003986 putative active site [active] 525897003987 heme pocket [chemical binding]; other site 525897003988 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897003989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897003990 dimer interface [polypeptide binding]; other site 525897003991 phosphorylation site [posttranslational modification] 525897003992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897003993 ATP binding site [chemical binding]; other site 525897003994 Mg2+ binding site [ion binding]; other site 525897003995 G-X-G motif; other site 525897003996 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 525897003997 DNA binding site [nucleotide binding] 525897003998 active site 525897003999 Hemerythrin-like domain; Region: Hr-like; cd12108 525897004000 Fe binding site [ion binding]; other site 525897004001 Uncharacterized conserved protein [Function unknown]; Region: COG3189 525897004002 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 525897004003 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 525897004004 Part of AAA domain; Region: AAA_19; pfam13245 525897004005 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 525897004006 AAA domain; Region: AAA_30; pfam13604 525897004007 AAA domain; Region: AAA_12; pfam13087 525897004008 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 525897004009 putative active site [active] 525897004010 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 525897004011 Transposase; Region: DEDD_Tnp_IS110; pfam01548 525897004012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 525897004013 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 525897004014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897004015 S-adenosylmethionine binding site [chemical binding]; other site 525897004016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 525897004017 NIPSNAP; Region: NIPSNAP; pfam07978 525897004018 Predicted permeases [General function prediction only]; Region: COG0679 525897004019 DsrE/DsrF-like family; Region: DrsE; pfam02635 525897004020 metal-dependent hydrolase; Provisional; Region: PRK13291 525897004021 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 525897004022 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 525897004023 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897004024 dimerization interface [polypeptide binding]; other site 525897004025 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897004026 dimer interface [polypeptide binding]; other site 525897004027 putative CheW interface [polypeptide binding]; other site 525897004028 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 525897004029 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 525897004030 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 525897004031 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525897004032 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 525897004033 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 525897004034 TM-ABC transporter signature motif; other site 525897004035 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 525897004036 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 525897004037 TM-ABC transporter signature motif; other site 525897004038 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 525897004039 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 525897004040 Walker A/P-loop; other site 525897004041 ATP binding site [chemical binding]; other site 525897004042 Q-loop/lid; other site 525897004043 ABC transporter signature motif; other site 525897004044 Walker B; other site 525897004045 D-loop; other site 525897004046 H-loop/switch region; other site 525897004047 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 525897004048 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 525897004049 Walker A/P-loop; other site 525897004050 ATP binding site [chemical binding]; other site 525897004051 Q-loop/lid; other site 525897004052 ABC transporter signature motif; other site 525897004053 Walker B; other site 525897004054 D-loop; other site 525897004055 H-loop/switch region; other site 525897004056 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525897004057 Cysteine-rich domain; Region: CCG; pfam02754 525897004058 Cysteine-rich domain; Region: CCG; pfam02754 525897004059 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 525897004060 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 525897004061 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 525897004062 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 525897004063 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 525897004064 PAS domain S-box; Region: sensory_box; TIGR00229 525897004065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004066 putative active site [active] 525897004067 heme pocket [chemical binding]; other site 525897004068 PAS fold; Region: PAS_4; pfam08448 525897004069 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004070 PAS fold; Region: PAS_3; pfam08447 525897004071 putative active site [active] 525897004072 heme pocket [chemical binding]; other site 525897004073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897004074 dimer interface [polypeptide binding]; other site 525897004075 phosphorylation site [posttranslational modification] 525897004076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897004077 ATP binding site [chemical binding]; other site 525897004078 Mg2+ binding site [ion binding]; other site 525897004079 G-X-G motif; other site 525897004080 Response regulator receiver domain; Region: Response_reg; pfam00072 525897004081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897004082 active site 525897004083 phosphorylation site [posttranslational modification] 525897004084 intermolecular recognition site; other site 525897004085 dimerization interface [polypeptide binding]; other site 525897004086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 525897004087 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 525897004088 AAA domain; Region: AAA_33; pfam13671 525897004089 active site 525897004090 PspC domain; Region: PspC; pfam04024 525897004091 phage shock protein C; Region: phageshock_pspC; TIGR02978 525897004092 phage shock protein B; Region: phageshock_pspB; TIGR02976 525897004093 phage shock protein A; Region: phageshock_pspA; TIGR02977 525897004094 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 525897004095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897004096 Walker A motif; other site 525897004097 ATP binding site [chemical binding]; other site 525897004098 Walker B motif; other site 525897004099 arginine finger; other site 525897004100 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 525897004101 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 525897004102 GTP/Mg2+ binding site [chemical binding]; other site 525897004103 G4 box; other site 525897004104 G5 box; other site 525897004105 G1 box; other site 525897004106 Switch I region; other site 525897004107 G2 box; other site 525897004108 G3 box; other site 525897004109 Switch II region; other site 525897004110 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 525897004111 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 525897004112 active site 525897004113 Zn binding site [ion binding]; other site 525897004114 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 525897004115 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 525897004116 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 525897004117 active site 525897004118 HIGH motif; other site 525897004119 dimer interface [polypeptide binding]; other site 525897004120 KMSKS motif; other site 525897004121 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 525897004122 Peptidase family M50; Region: Peptidase_M50; pfam02163 525897004123 active site 525897004124 putative substrate binding region [chemical binding]; other site 525897004125 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 525897004126 Flavoprotein; Region: Flavoprotein; pfam02441 525897004127 Fic family protein [Function unknown]; Region: COG3177 525897004128 Fic/DOC family; Region: Fic; pfam02661 525897004129 Transposase; Region: HTH_Tnp_1; pfam01527 525897004130 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 525897004131 HTH-like domain; Region: HTH_21; pfam13276 525897004132 Integrase core domain; Region: rve; pfam00665 525897004133 Integrase core domain; Region: rve_3; pfam13683 525897004134 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 525897004135 HEAT repeats; Region: HEAT_2; pfam13646 525897004136 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 525897004137 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 525897004138 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 525897004139 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 525897004140 N-acetyl-D-glucosamine binding site [chemical binding]; other site 525897004141 catalytic residue [active] 525897004142 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 525897004143 active site 525897004144 Catalytic domain of Protein Kinases; Region: PKc; cd00180 525897004145 active site 525897004146 ATP binding site [chemical binding]; other site 525897004147 substrate binding site [chemical binding]; other site 525897004148 activation loop (A-loop); other site 525897004149 Uncharacterized conserved protein [Function unknown]; Region: COG1262 525897004150 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 525897004151 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 525897004152 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 525897004153 active site 525897004154 NTP binding site [chemical binding]; other site 525897004155 metal binding triad [ion binding]; metal-binding site 525897004156 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 525897004157 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897004158 Zn2+ binding site [ion binding]; other site 525897004159 Mg2+ binding site [ion binding]; other site 525897004160 Methyltransferase domain; Region: Methyltransf_23; pfam13489 525897004161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897004162 S-adenosylmethionine binding site [chemical binding]; other site 525897004163 RNA ligase; Region: RNA_ligase; pfam09414 525897004164 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897004165 Zn2+ binding site [ion binding]; other site 525897004166 Mg2+ binding site [ion binding]; other site 525897004167 AAA domain; Region: AAA_33; pfam13671 525897004168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 525897004169 Walker A motif; other site 525897004170 ATP binding site [chemical binding]; other site 525897004171 Walker B motif; other site 525897004172 arginine finger; other site 525897004173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897004174 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525897004175 Walker A motif; other site 525897004176 ATP binding site [chemical binding]; other site 525897004177 Walker B motif; other site 525897004178 arginine finger; other site 525897004179 Uncharacterized conserved protein [Function unknown]; Region: COG1262 525897004180 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 525897004181 Uncharacterized conserved protein [Function unknown]; Region: COG1262 525897004182 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 525897004183 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 525897004184 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 525897004185 metal ion-dependent adhesion site (MIDAS); other site 525897004186 NLI interacting factor-like phosphatase; Region: NIF; cl17354 525897004187 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 525897004188 Catalytic domain of Protein Kinases; Region: PKc; cd00180 525897004189 active site 525897004190 ATP binding site [chemical binding]; other site 525897004191 substrate binding site [chemical binding]; other site 525897004192 activation loop (A-loop); other site 525897004193 Uncharacterized conserved protein [Function unknown]; Region: COG1262 525897004194 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 525897004195 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 525897004196 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525897004197 active site 525897004198 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 525897004199 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897004200 FeS/SAM binding site; other site 525897004201 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897004202 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525897004203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525897004204 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897004205 Radical SAM superfamily; Region: Radical_SAM; pfam04055 525897004206 FeS/SAM binding site; other site 525897004207 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 525897004208 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525897004209 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 525897004210 active site 525897004211 Radical SAM superfamily; Region: Radical_SAM; pfam04055 525897004212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897004213 FeS/SAM binding site; other site 525897004214 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525897004215 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 525897004216 hypothetical protein; Reviewed; Region: PRK09588 525897004217 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 525897004218 Helix-turn-helix domain; Region: HTH_17; pfam12728 525897004219 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 525897004220 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 525897004221 Transposase; Region: HTH_Tnp_1; pfam01527 525897004222 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 525897004223 HTH-like domain; Region: HTH_21; pfam13276 525897004224 Integrase core domain; Region: rve; pfam00665 525897004225 Integrase core domain; Region: rve_3; pfam13683 525897004226 AAA domain; Region: AAA_11; pfam13086 525897004227 Part of AAA domain; Region: AAA_19; pfam13245 525897004228 AAA domain; Region: AAA_12; pfam13087 525897004229 Uncharacterized conserved protein [Function unknown]; Region: COG3339 525897004230 Predicted transcriptional regulator [Transcription]; Region: COG2378 525897004231 WYL domain; Region: WYL; pfam13280 525897004232 Nuclease-related domain; Region: NERD; pfam08378 525897004233 AAA ATPase domain; Region: AAA_16; pfam13191 525897004234 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 525897004235 Family description; Region: UvrD_C_2; pfam13538 525897004236 Predicted transcriptional regulator [Transcription]; Region: COG2378 525897004237 WYL domain; Region: WYL; pfam13280 525897004238 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 525897004239 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 525897004240 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 525897004241 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 525897004242 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 525897004243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897004244 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525897004245 Walker A motif; other site 525897004246 ATP binding site [chemical binding]; other site 525897004247 Walker B motif; other site 525897004248 arginine finger; other site 525897004249 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525897004250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897004251 Walker A motif; other site 525897004252 ATP binding site [chemical binding]; other site 525897004253 Walker B motif; other site 525897004254 arginine finger; other site 525897004255 DEAD-like helicases superfamily; Region: DEXDc; smart00487 525897004256 DEAD-like helicases superfamily; Region: DEXDc; smart00487 525897004257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525897004258 ATP-binding site [chemical binding]; other site 525897004259 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 525897004260 putative active site [active] 525897004261 catalytic site [active] 525897004262 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 525897004263 PLD-like domain; Region: PLDc_2; pfam13091 525897004264 putative homodimer interface [polypeptide binding]; other site 525897004265 putative active site [active] 525897004266 catalytic site [active] 525897004267 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 525897004268 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 525897004269 ThiF family; Region: ThiF; pfam00899 525897004270 ATP binding site [chemical binding]; other site 525897004271 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 525897004272 active site 525897004273 NTP binding site [chemical binding]; other site 525897004274 metal binding triad [ion binding]; metal-binding site 525897004275 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 525897004276 active site 525897004277 nucleophile elbow; other site 525897004278 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 525897004279 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 525897004280 AIPR protein; Region: AIPR; pfam10592 525897004281 Methyltransferase domain; Region: Methyltransf_26; pfam13659 525897004282 Methyltransferase domain; Region: Methyltransf_26; pfam13659 525897004283 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 525897004284 Nuclease-related domain; Region: NERD; pfam08378 525897004285 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 525897004286 active site 525897004287 metal binding site [ion binding]; metal-binding site 525897004288 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 525897004289 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 525897004290 active site 525897004291 metal binding site [ion binding]; metal-binding site 525897004292 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 525897004293 active site 525897004294 metal binding site [ion binding]; metal-binding site 525897004295 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 525897004296 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 525897004297 active site 525897004298 metal binding site [ion binding]; metal-binding site 525897004299 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525897004300 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 525897004301 active site 525897004302 Int/Topo IB signature motif; other site 525897004303 DNA binding site [nucleotide binding] 525897004304 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525897004305 active site 525897004306 Int/Topo IB signature motif; other site 525897004307 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 525897004308 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 525897004309 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 525897004310 GAF domain; Region: GAF; pfam01590 525897004311 GAF domain; Region: GAF_2; pfam13185 525897004312 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897004313 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 525897004314 active site 525897004315 putative substrate binding region [chemical binding]; other site 525897004316 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 525897004317 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 525897004318 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525897004319 nucleotide binding region [chemical binding]; other site 525897004320 ATP-binding site [chemical binding]; other site 525897004321 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525897004322 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897004323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897004324 TPR motif; other site 525897004325 binding surface 525897004326 TPR repeat; Region: TPR_11; pfam13414 525897004327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897004328 TPR repeat; Region: TPR_11; pfam13414 525897004329 binding surface 525897004330 TPR motif; other site 525897004331 aspartate kinase; Validated; Region: PRK09181 525897004332 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 525897004333 nucleotide binding site [chemical binding]; other site 525897004334 substrate binding site [chemical binding]; other site 525897004335 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 525897004336 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 525897004337 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 525897004338 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 525897004339 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 525897004340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897004341 dimer interface [polypeptide binding]; other site 525897004342 conserved gate region; other site 525897004343 putative PBP binding loops; other site 525897004344 ABC-ATPase subunit interface; other site 525897004345 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 525897004346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897004347 dimer interface [polypeptide binding]; other site 525897004348 conserved gate region; other site 525897004349 ABC-ATPase subunit interface; other site 525897004350 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 525897004351 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525897004352 Walker A/P-loop; other site 525897004353 ATP binding site [chemical binding]; other site 525897004354 Q-loop/lid; other site 525897004355 ABC transporter signature motif; other site 525897004356 Walker B; other site 525897004357 D-loop; other site 525897004358 H-loop/switch region; other site 525897004359 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 525897004360 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525897004361 Walker A/P-loop; other site 525897004362 ATP binding site [chemical binding]; other site 525897004363 Q-loop/lid; other site 525897004364 ABC transporter signature motif; other site 525897004365 Walker B; other site 525897004366 D-loop; other site 525897004367 H-loop/switch region; other site 525897004368 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 525897004369 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 525897004370 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 525897004371 TrkA-N domain; Region: TrkA_N; pfam02254 525897004372 TrkA-C domain; Region: TrkA_C; pfam02080 525897004373 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 525897004374 active site 525897004375 DEAD-like helicases superfamily; Region: DEXDc; smart00487 525897004376 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525897004377 ATP binding site [chemical binding]; other site 525897004378 putative Mg++ binding site [ion binding]; other site 525897004379 nucleotide binding region [chemical binding]; other site 525897004380 helicase superfamily c-terminal domain; Region: HELICc; smart00490 525897004381 ATP-binding site [chemical binding]; other site 525897004382 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897004383 Zn2+ binding site [ion binding]; other site 525897004384 Mg2+ binding site [ion binding]; other site 525897004385 putative phosphoketolase; Provisional; Region: PRK05261 525897004386 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 525897004387 TPP-binding site; other site 525897004388 XFP C-terminal domain; Region: XFP_C; pfam09363 525897004389 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 525897004390 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004391 PAS domain; Region: PAS_9; pfam13426 525897004392 putative active site [active] 525897004393 heme pocket [chemical binding]; other site 525897004394 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 525897004395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897004396 Walker A motif; other site 525897004397 ATP binding site [chemical binding]; other site 525897004398 Walker B motif; other site 525897004399 arginine finger; other site 525897004400 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897004401 Fic family protein [Function unknown]; Region: COG3177 525897004402 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 525897004403 Fic/DOC family; Region: Fic; pfam02661 525897004404 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 525897004405 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 525897004406 HicB family; Region: HicB; pfam05534 525897004407 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 525897004408 domain_subunit interface; other site 525897004409 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 525897004410 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 525897004411 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 525897004412 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897004413 4Fe-4S binding domain; Region: Fer4_6; pfam12837 525897004414 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 525897004415 4Fe-4S binding domain; Region: Fer4; pfam00037 525897004416 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 525897004417 phosphate binding site [ion binding]; other site 525897004418 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 525897004419 putative active site [active] 525897004420 Pathogenicity locus; Region: Cdd1; pfam11731 525897004421 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 525897004422 N-acetyl-D-glucosamine binding site [chemical binding]; other site 525897004423 catalytic residue [active] 525897004424 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 525897004425 N-acetyl-D-glucosamine binding site [chemical binding]; other site 525897004426 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 525897004427 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 525897004428 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 525897004429 catalytic residues [active] 525897004430 shikimate kinase; Reviewed; Region: aroK; PRK00131 525897004431 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 525897004432 ADP binding site [chemical binding]; other site 525897004433 magnesium binding site [ion binding]; other site 525897004434 putative shikimate binding site; other site 525897004435 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897004436 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 525897004437 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 525897004438 SlyX; Region: SlyX; pfam04102 525897004439 HDOD domain; Region: HDOD; pfam08668 525897004440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 525897004441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897004442 ATP binding site [chemical binding]; other site 525897004443 Mg2+ binding site [ion binding]; other site 525897004444 G-X-G motif; other site 525897004445 Response regulator receiver domain; Region: Response_reg; pfam00072 525897004446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897004447 active site 525897004448 phosphorylation site [posttranslational modification] 525897004449 intermolecular recognition site; other site 525897004450 dimerization interface [polypeptide binding]; other site 525897004451 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 525897004452 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 525897004453 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 525897004454 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525897004455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897004456 homodimer interface [polypeptide binding]; other site 525897004457 catalytic residue [active] 525897004458 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 525897004459 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 525897004460 nudix motif; other site 525897004461 glutamate racemase; Provisional; Region: PRK00865 525897004462 HDOD domain; Region: HDOD; pfam08668 525897004463 poly(A) polymerase; Region: pcnB; TIGR01942 525897004464 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 525897004465 active site 525897004466 NTP binding site [chemical binding]; other site 525897004467 metal binding triad [ion binding]; metal-binding site 525897004468 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 525897004469 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 525897004470 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 525897004471 GIY-YIG motif/motif A; other site 525897004472 active site 525897004473 catalytic site [active] 525897004474 putative DNA binding site [nucleotide binding]; other site 525897004475 metal binding site [ion binding]; metal-binding site 525897004476 UvrB/uvrC motif; Region: UVR; pfam02151 525897004477 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 525897004478 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 525897004479 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 525897004480 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 525897004481 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 525897004482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897004483 Walker A/P-loop; other site 525897004484 ATP binding site [chemical binding]; other site 525897004485 Q-loop/lid; other site 525897004486 Walker B; other site 525897004487 D-loop; other site 525897004488 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 525897004489 nudix motif; other site 525897004490 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 525897004491 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 525897004492 catalytic residues [active] 525897004493 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 525897004494 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525897004495 RNA binding surface [nucleotide binding]; other site 525897004496 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 525897004497 active site 525897004498 META domain; Region: META; pfam03724 525897004499 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 525897004500 active site clefts [active] 525897004501 zinc binding site [ion binding]; other site 525897004502 dimer interface [polypeptide binding]; other site 525897004503 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 525897004504 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 525897004505 putative ligand binding site [chemical binding]; other site 525897004506 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 525897004507 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 525897004508 Walker A/P-loop; other site 525897004509 ATP binding site [chemical binding]; other site 525897004510 Q-loop/lid; other site 525897004511 ABC transporter signature motif; other site 525897004512 Walker B; other site 525897004513 D-loop; other site 525897004514 H-loop/switch region; other site 525897004515 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 525897004516 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525897004517 acyl-activating enzyme (AAE) consensus motif; other site 525897004518 AMP binding site [chemical binding]; other site 525897004519 active site 525897004520 CoA binding site [chemical binding]; other site 525897004521 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 525897004522 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 525897004523 Walker A/P-loop; other site 525897004524 ATP binding site [chemical binding]; other site 525897004525 Q-loop/lid; other site 525897004526 ABC transporter signature motif; other site 525897004527 Walker B; other site 525897004528 D-loop; other site 525897004529 H-loop/switch region; other site 525897004530 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 525897004531 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 525897004532 TM-ABC transporter signature motif; other site 525897004533 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525897004534 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 525897004535 TM-ABC transporter signature motif; other site 525897004536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004537 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897004538 putative active site [active] 525897004539 heme pocket [chemical binding]; other site 525897004540 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004541 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897004542 putative active site [active] 525897004543 heme pocket [chemical binding]; other site 525897004544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004545 putative active site [active] 525897004546 heme pocket [chemical binding]; other site 525897004547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897004548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897004549 phosphorylation site [posttranslational modification] 525897004550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897004551 ATP binding site [chemical binding]; other site 525897004552 Mg2+ binding site [ion binding]; other site 525897004553 G-X-G motif; other site 525897004554 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897004555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897004556 active site 525897004557 phosphorylation site [posttranslational modification] 525897004558 intermolecular recognition site; other site 525897004559 dimerization interface [polypeptide binding]; other site 525897004560 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 525897004561 CheB methylesterase; Region: CheB_methylest; pfam01339 525897004562 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 525897004563 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 525897004564 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 525897004565 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 525897004566 PAS domain; Region: PAS_10; pfam13596 525897004567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 525897004568 putative active site [active] 525897004569 heme pocket [chemical binding]; other site 525897004570 PAS domain S-box; Region: sensory_box; TIGR00229 525897004571 PAS domain; Region: PAS; smart00091 525897004572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004573 putative active site [active] 525897004574 heme pocket [chemical binding]; other site 525897004575 photoactive yellow protein; Region: photo_yellow; TIGR02373 525897004576 PAS domain S-box; Region: sensory_box; TIGR00229 525897004577 PAS domain S-box; Region: sensory_box; TIGR00229 525897004578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004579 putative active site [active] 525897004580 heme pocket [chemical binding]; other site 525897004581 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004582 PAS domain; Region: PAS_9; pfam13426 525897004583 putative active site [active] 525897004584 heme pocket [chemical binding]; other site 525897004585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897004586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897004587 dimer interface [polypeptide binding]; other site 525897004588 phosphorylation site [posttranslational modification] 525897004589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897004590 ATP binding site [chemical binding]; other site 525897004591 Mg2+ binding site [ion binding]; other site 525897004592 G-X-G motif; other site 525897004593 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 525897004594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897004595 ATP binding site [chemical binding]; other site 525897004596 Mg2+ binding site [ion binding]; other site 525897004597 G-X-G motif; other site 525897004598 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 525897004599 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 525897004600 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004601 PAS fold; Region: PAS_3; pfam08447 525897004602 putative active site [active] 525897004603 heme pocket [chemical binding]; other site 525897004604 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897004605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897004606 dimer interface [polypeptide binding]; other site 525897004607 phosphorylation site [posttranslational modification] 525897004608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897004609 ATP binding site [chemical binding]; other site 525897004610 Mg2+ binding site [ion binding]; other site 525897004611 G-X-G motif; other site 525897004612 Response regulator receiver domain; Region: Response_reg; pfam00072 525897004613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897004614 active site 525897004615 phosphorylation site [posttranslational modification] 525897004616 intermolecular recognition site; other site 525897004617 dimerization interface [polypeptide binding]; other site 525897004618 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 525897004619 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 525897004620 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 525897004621 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 525897004622 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 525897004623 putative binding surface; other site 525897004624 active site 525897004625 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 525897004626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897004627 ATP binding site [chemical binding]; other site 525897004628 Mg2+ binding site [ion binding]; other site 525897004629 G-X-G motif; other site 525897004630 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 525897004631 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897004632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897004633 active site 525897004634 phosphorylation site [posttranslational modification] 525897004635 intermolecular recognition site; other site 525897004636 dimerization interface [polypeptide binding]; other site 525897004637 STAS domain; Region: STAS_2; pfam13466 525897004638 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 525897004639 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897004640 dimer interface [polypeptide binding]; other site 525897004641 putative CheW interface [polypeptide binding]; other site 525897004642 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 525897004643 putative CheA interaction surface; other site 525897004644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897004645 dimerization interface [polypeptide binding]; other site 525897004646 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897004647 dimer interface [polypeptide binding]; other site 525897004648 putative CheW interface [polypeptide binding]; other site 525897004649 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525897004650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525897004651 non-specific DNA binding site [nucleotide binding]; other site 525897004652 salt bridge; other site 525897004653 sequence-specific DNA binding site [nucleotide binding]; other site 525897004654 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004655 PAS fold; Region: PAS_3; pfam08447 525897004656 putative active site [active] 525897004657 heme pocket [chemical binding]; other site 525897004658 PAS fold; Region: PAS_4; pfam08448 525897004659 PAS domain S-box; Region: sensory_box; TIGR00229 525897004660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004661 putative active site [active] 525897004662 heme pocket [chemical binding]; other site 525897004663 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525897004664 PAS domain S-box; Region: sensory_box; TIGR00229 525897004665 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004666 putative active site [active] 525897004667 heme pocket [chemical binding]; other site 525897004668 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004669 PAS fold; Region: PAS_3; pfam08447 525897004670 putative active site [active] 525897004671 heme pocket [chemical binding]; other site 525897004672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897004673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897004674 dimer interface [polypeptide binding]; other site 525897004675 phosphorylation site [posttranslational modification] 525897004676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897004677 ATP binding site [chemical binding]; other site 525897004678 Mg2+ binding site [ion binding]; other site 525897004679 G-X-G motif; other site 525897004680 Response regulator receiver domain; Region: Response_reg; pfam00072 525897004681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897004682 active site 525897004683 phosphorylation site [posttranslational modification] 525897004684 intermolecular recognition site; other site 525897004685 dimerization interface [polypeptide binding]; other site 525897004686 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897004687 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004688 putative active site [active] 525897004689 heme pocket [chemical binding]; other site 525897004690 GAF domain; Region: GAF_2; pfam13185 525897004691 GAF domain; Region: GAF; cl17456 525897004692 PAS domain; Region: PAS_9; pfam13426 525897004693 PAS domain; Region: PAS; smart00091 525897004694 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 525897004695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897004696 dimer interface [polypeptide binding]; other site 525897004697 phosphorylation site [posttranslational modification] 525897004698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897004699 ATP binding site [chemical binding]; other site 525897004700 Mg2+ binding site [ion binding]; other site 525897004701 G-X-G motif; other site 525897004702 Response regulator receiver domain; Region: Response_reg; pfam00072 525897004703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897004704 active site 525897004705 phosphorylation site [posttranslational modification] 525897004706 intermolecular recognition site; other site 525897004707 dimerization interface [polypeptide binding]; other site 525897004708 Sensory domain found in PocR; Region: PocR; pfam10114 525897004709 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 525897004710 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004711 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897004712 putative active site [active] 525897004713 heme pocket [chemical binding]; other site 525897004714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004715 putative active site [active] 525897004716 heme pocket [chemical binding]; other site 525897004717 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 525897004718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004719 putative active site [active] 525897004720 heme pocket [chemical binding]; other site 525897004721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897004722 dimer interface [polypeptide binding]; other site 525897004723 phosphorylation site [posttranslational modification] 525897004724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897004725 ATP binding site [chemical binding]; other site 525897004726 Mg2+ binding site [ion binding]; other site 525897004727 G-X-G motif; other site 525897004728 Response regulator receiver domain; Region: Response_reg; pfam00072 525897004729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897004730 active site 525897004731 phosphorylation site [posttranslational modification] 525897004732 intermolecular recognition site; other site 525897004733 dimerization interface [polypeptide binding]; other site 525897004734 Response regulator receiver domain; Region: Response_reg; pfam00072 525897004735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897004736 active site 525897004737 phosphorylation site [posttranslational modification] 525897004738 intermolecular recognition site; other site 525897004739 dimerization interface [polypeptide binding]; other site 525897004740 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 525897004741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897004742 active site 525897004743 phosphorylation site [posttranslational modification] 525897004744 intermolecular recognition site; other site 525897004745 dimerization interface [polypeptide binding]; other site 525897004746 CheB methylesterase; Region: CheB_methylest; pfam01339 525897004747 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 525897004748 CheD chemotactic sensory transduction; Region: CheD; cl00810 525897004749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004750 PAS fold; Region: PAS_3; pfam08447 525897004751 putative active site [active] 525897004752 heme pocket [chemical binding]; other site 525897004753 PAS fold; Region: PAS_4; pfam08448 525897004754 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 525897004755 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897004756 Walker B motif; other site 525897004757 arginine finger; other site 525897004758 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897004759 PAS fold; Region: PAS_4; pfam08448 525897004760 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004761 putative active site [active] 525897004762 heme pocket [chemical binding]; other site 525897004763 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 525897004764 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897004765 putative active site [active] 525897004766 heme pocket [chemical binding]; other site 525897004767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897004768 dimer interface [polypeptide binding]; other site 525897004769 phosphorylation site [posttranslational modification] 525897004770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897004771 ATP binding site [chemical binding]; other site 525897004772 Mg2+ binding site [ion binding]; other site 525897004773 G-X-G motif; other site 525897004774 Response regulator receiver domain; Region: Response_reg; pfam00072 525897004775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897004776 active site 525897004777 phosphorylation site [posttranslational modification] 525897004778 intermolecular recognition site; other site 525897004779 dimerization interface [polypeptide binding]; other site 525897004780 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 525897004781 Transposase; Region: DDE_Tnp_ISL3; pfam01610 525897004782 glycerol kinase; Provisional; Region: glpK; PRK00047 525897004783 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 525897004784 N- and C-terminal domain interface [polypeptide binding]; other site 525897004785 active site 525897004786 MgATP binding site [chemical binding]; other site 525897004787 catalytic site [active] 525897004788 metal binding site [ion binding]; metal-binding site 525897004789 putative homotetramer interface [polypeptide binding]; other site 525897004790 glycerol binding site [chemical binding]; other site 525897004791 homodimer interface [polypeptide binding]; other site 525897004792 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 525897004793 Cysteine-rich domain; Region: CCG; pfam02754 525897004794 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 525897004795 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897004796 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 525897004797 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 525897004798 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 525897004799 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 525897004800 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 525897004801 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 525897004802 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 525897004803 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 525897004804 Walker A/P-loop; other site 525897004805 ATP binding site [chemical binding]; other site 525897004806 Q-loop/lid; other site 525897004807 ABC transporter signature motif; other site 525897004808 Walker B; other site 525897004809 D-loop; other site 525897004810 H-loop/switch region; other site 525897004811 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 525897004812 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 525897004813 Walker A/P-loop; other site 525897004814 ATP binding site [chemical binding]; other site 525897004815 Q-loop/lid; other site 525897004816 ABC transporter signature motif; other site 525897004817 Walker B; other site 525897004818 D-loop; other site 525897004819 H-loop/switch region; other site 525897004820 TOBE domain; Region: TOBE_2; pfam08402 525897004821 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 525897004822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897004823 dimer interface [polypeptide binding]; other site 525897004824 conserved gate region; other site 525897004825 putative PBP binding loops; other site 525897004826 ABC-ATPase subunit interface; other site 525897004827 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 525897004828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897004829 dimer interface [polypeptide binding]; other site 525897004830 conserved gate region; other site 525897004831 ABC-ATPase subunit interface; other site 525897004832 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 525897004833 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 525897004834 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 525897004835 competence damage-inducible protein A; Provisional; Region: PRK01215 525897004836 putative MPT binding site; other site 525897004837 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 525897004838 PilZ domain; Region: PilZ; pfam07238 525897004839 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 525897004840 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 525897004841 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 525897004842 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525897004843 P-loop; other site 525897004844 Magnesium ion binding site [ion binding]; other site 525897004845 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 525897004846 DNA topoisomerase III; Provisional; Region: PRK07726 525897004847 active site 525897004848 putative interdomain interaction site [polypeptide binding]; other site 525897004849 putative metal-binding site [ion binding]; other site 525897004850 putative nucleotide binding site [chemical binding]; other site 525897004851 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 525897004852 domain I; other site 525897004853 DNA binding groove [nucleotide binding] 525897004854 phosphate binding site [ion binding]; other site 525897004855 domain II; other site 525897004856 domain III; other site 525897004857 nucleotide binding site [chemical binding]; other site 525897004858 catalytic site [active] 525897004859 domain IV; other site 525897004860 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897004861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897004862 active site 525897004863 phosphorylation site [posttranslational modification] 525897004864 intermolecular recognition site; other site 525897004865 dimerization interface [polypeptide binding]; other site 525897004866 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 525897004867 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 525897004868 active site 525897004869 intersubunit interactions; other site 525897004870 catalytic residue [active] 525897004871 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 525897004872 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 525897004873 catalytic center binding site [active] 525897004874 ATP binding site [chemical binding]; other site 525897004875 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 525897004876 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 525897004877 active site 525897004878 Int/Topo IB signature motif; other site 525897004879 DHH family; Region: DHH; pfam01368 525897004880 FOG: CBS domain [General function prediction only]; Region: COG0517 525897004881 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 525897004882 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 525897004883 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 525897004884 active site 525897004885 NTP binding site [chemical binding]; other site 525897004886 metal binding triad [ion binding]; metal-binding site 525897004887 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 525897004888 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 525897004889 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525897004890 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525897004891 substrate binding pocket [chemical binding]; other site 525897004892 membrane-bound complex binding site; other site 525897004893 hinge residues; other site 525897004894 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 525897004895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897004896 dimer interface [polypeptide binding]; other site 525897004897 conserved gate region; other site 525897004898 putative PBP binding loops; other site 525897004899 ABC-ATPase subunit interface; other site 525897004900 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525897004901 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 525897004902 Walker A/P-loop; other site 525897004903 ATP binding site [chemical binding]; other site 525897004904 Q-loop/lid; other site 525897004905 ABC transporter signature motif; other site 525897004906 Walker B; other site 525897004907 D-loop; other site 525897004908 H-loop/switch region; other site 525897004909 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 525897004910 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 525897004911 nucleotide binding site/active site [active] 525897004912 HIT family signature motif; other site 525897004913 catalytic residue [active] 525897004914 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 525897004915 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 525897004916 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 525897004917 NAD binding site [chemical binding]; other site 525897004918 substrate binding site [chemical binding]; other site 525897004919 homodimer interface [polypeptide binding]; other site 525897004920 active site 525897004921 tetratricopeptide repeat protein; Provisional; Region: PRK11788 525897004922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 525897004923 binding surface 525897004924 TPR motif; other site 525897004925 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 525897004926 MutS domain I; Region: MutS_I; pfam01624 525897004927 MutS domain II; Region: MutS_II; pfam05188 525897004928 MutS domain III; Region: MutS_III; pfam05192 525897004929 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 525897004930 Walker A/P-loop; other site 525897004931 ATP binding site [chemical binding]; other site 525897004932 Q-loop/lid; other site 525897004933 ABC transporter signature motif; other site 525897004934 Walker B; other site 525897004935 D-loop; other site 525897004936 H-loop/switch region; other site 525897004937 diaminopimelate decarboxylase; Region: lysA; TIGR01048 525897004938 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 525897004939 active site 525897004940 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525897004941 substrate binding site [chemical binding]; other site 525897004942 catalytic residues [active] 525897004943 dimer interface [polypeptide binding]; other site 525897004944 Predicted permeases [General function prediction only]; Region: COG0701 525897004945 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525897004946 putative DNA binding site [nucleotide binding]; other site 525897004947 putative Zn2+ binding site [ion binding]; other site 525897004948 PAS domain; Region: PAS_9; pfam13426 525897004949 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897004950 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897004951 metal binding site [ion binding]; metal-binding site 525897004952 active site 525897004953 I-site; other site 525897004954 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 525897004955 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525897004956 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 525897004957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525897004958 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 525897004959 EamA-like transporter family; Region: EamA; pfam00892 525897004960 EamA-like transporter family; Region: EamA; pfam00892 525897004961 Protein of unknown function DUF86; Region: DUF86; cl01031 525897004962 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 525897004963 active site 525897004964 NTP binding site [chemical binding]; other site 525897004965 metal binding triad [ion binding]; metal-binding site 525897004966 antibiotic binding site [chemical binding]; other site 525897004967 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 525897004968 dimer interface [polypeptide binding]; other site 525897004969 Citrate synthase; Region: Citrate_synt; pfam00285 525897004970 active site 525897004971 citrylCoA binding site [chemical binding]; other site 525897004972 NADH binding [chemical binding]; other site 525897004973 cationic pore residues; other site 525897004974 oxalacetate/citrate binding site [chemical binding]; other site 525897004975 coenzyme A binding site [chemical binding]; other site 525897004976 catalytic triad [active] 525897004977 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 525897004978 CoA binding domain; Region: CoA_binding_2; pfam13380 525897004979 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 525897004980 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 525897004981 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525897004982 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 525897004983 acetyl-CoA synthetase; Provisional; Region: PRK00174 525897004984 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 525897004985 active site 525897004986 CoA binding site [chemical binding]; other site 525897004987 acyl-activating enzyme (AAE) consensus motif; other site 525897004988 AMP binding site [chemical binding]; other site 525897004989 acetate binding site [chemical binding]; other site 525897004990 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525897004991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525897004992 H+ Antiporter protein; Region: 2A0121; TIGR00900 525897004993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525897004994 putative substrate translocation pore; other site 525897004995 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 525897004996 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 525897004997 putative acyl-acceptor binding pocket; other site 525897004998 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525897004999 AMP-binding enzyme; Region: AMP-binding; pfam00501 525897005000 acyl-activating enzyme (AAE) consensus motif; other site 525897005001 active site 525897005002 AMP binding site [chemical binding]; other site 525897005003 CoA binding site [chemical binding]; other site 525897005004 Ubiquitin-like proteins; Region: UBQ; cl00155 525897005005 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 525897005006 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 525897005007 Ligand Binding Site [chemical binding]; other site 525897005008 TIGR00269 family protein; Region: TIGR00269 525897005009 Response regulator receiver domain; Region: Response_reg; pfam00072 525897005010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897005011 active site 525897005012 phosphorylation site [posttranslational modification] 525897005013 intermolecular recognition site; other site 525897005014 dimerization interface [polypeptide binding]; other site 525897005015 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897005016 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897005017 metal binding site [ion binding]; metal-binding site 525897005018 active site 525897005019 I-site; other site 525897005020 Transposase; Region: DEDD_Tnp_IS110; pfam01548 525897005021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 525897005022 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 525897005023 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 525897005024 AAA domain; Region: AAA_13; pfam13166 525897005025 Transposase; Region: HTH_Tnp_1; pfam01527 525897005026 putative transposase OrfB; Reviewed; Region: PHA02517 525897005027 HTH-like domain; Region: HTH_21; pfam13276 525897005028 Integrase core domain; Region: rve; pfam00665 525897005029 Integrase core domain; Region: rve_3; pfam13683 525897005030 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 525897005031 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 525897005032 active site 525897005033 catalytic residues [active] 525897005034 DNA binding site [nucleotide binding] 525897005035 Int/Topo IB signature motif; other site 525897005036 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 525897005037 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 525897005038 substrate binding site [chemical binding]; other site 525897005039 ATP binding site [chemical binding]; other site 525897005040 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 525897005041 Domain of unknown function DUF20; Region: UPF0118; pfam01594 525897005042 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 525897005043 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 525897005044 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 525897005045 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 525897005046 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 525897005047 homodimer interface [polypeptide binding]; other site 525897005048 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 525897005049 active site pocket [active] 525897005050 methionine sulfoxide reductase B; Provisional; Region: PRK00222 525897005051 SelR domain; Region: SelR; pfam01641 525897005052 3D domain; Region: 3D; cl01439 525897005053 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 525897005054 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 525897005055 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 525897005056 active site 525897005057 (T/H)XGH motif; other site 525897005058 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 525897005059 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 525897005060 putative catalytic cysteine [active] 525897005061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 525897005062 GAF domain; Region: GAF; pfam01590 525897005063 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 525897005064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897005065 Walker A motif; other site 525897005066 ATP binding site [chemical binding]; other site 525897005067 Walker B motif; other site 525897005068 arginine finger; other site 525897005069 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897005070 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897005071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897005072 ATP binding site [chemical binding]; other site 525897005073 Mg2+ binding site [ion binding]; other site 525897005074 G-X-G motif; other site 525897005075 Response regulator receiver domain; Region: Response_reg; pfam00072 525897005076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897005077 active site 525897005078 phosphorylation site [posttranslational modification] 525897005079 intermolecular recognition site; other site 525897005080 dimerization interface [polypeptide binding]; other site 525897005081 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897005082 PAS domain; Region: PAS_9; pfam13426 525897005083 putative active site [active] 525897005084 heme pocket [chemical binding]; other site 525897005085 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 525897005086 dimer interface [polypeptide binding]; other site 525897005087 phosphorylation site [posttranslational modification] 525897005088 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 525897005089 active site 525897005090 substrate binding site; other site 525897005091 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525897005092 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897005093 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897005094 metal binding site [ion binding]; metal-binding site 525897005095 active site 525897005096 I-site; other site 525897005097 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 525897005098 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 525897005099 HAMP domain; Region: HAMP; pfam00672 525897005100 dimerization interface [polypeptide binding]; other site 525897005101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897005102 dimer interface [polypeptide binding]; other site 525897005103 putative CheW interface [polypeptide binding]; other site 525897005104 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 525897005105 HAMP domain; Region: HAMP; pfam00672 525897005106 dimerization interface [polypeptide binding]; other site 525897005107 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525897005108 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897005109 dimer interface [polypeptide binding]; other site 525897005110 putative CheW interface [polypeptide binding]; other site 525897005111 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 525897005112 NMT1/THI5 like; Region: NMT1; pfam09084 525897005113 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 525897005114 substrate binding pocket [chemical binding]; other site 525897005115 membrane-bound complex binding site; other site 525897005116 PAS domain S-box; Region: sensory_box; TIGR00229 525897005117 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897005118 putative active site [active] 525897005119 heme pocket [chemical binding]; other site 525897005120 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897005121 PAS domain; Region: PAS_9; pfam13426 525897005122 putative active site [active] 525897005123 heme pocket [chemical binding]; other site 525897005124 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897005125 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897005126 metal binding site [ion binding]; metal-binding site 525897005127 active site 525897005128 I-site; other site 525897005129 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 525897005130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 525897005131 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 525897005132 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 525897005133 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 525897005134 S1 domain; Region: S1_2; pfam13509 525897005135 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 525897005136 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 525897005137 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 525897005138 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 525897005139 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 525897005140 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 525897005141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 525897005142 haemagglutination activity domain; Region: Haemagg_act; pfam05860 525897005143 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 525897005144 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 525897005145 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 525897005146 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 525897005147 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 525897005148 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 525897005149 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 525897005150 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 525897005151 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 525897005152 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 525897005153 CGGC domain; Region: CGGC; cl02356 525897005154 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525897005155 Ligand Binding Site [chemical binding]; other site 525897005156 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 525897005157 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 525897005158 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 525897005159 DNA binding residues [nucleotide binding] 525897005160 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 525897005161 Tetratricopeptide repeat; Region: TPR_16; pfam13432 525897005162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897005163 binding surface 525897005164 Tetratricopeptide repeat; Region: TPR_16; pfam13432 525897005165 TPR motif; other site 525897005166 Tetratricopeptide repeat; Region: TPR_16; pfam13432 525897005167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 525897005168 binding surface 525897005169 TPR motif; other site 525897005170 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 525897005171 ligand binding site [chemical binding]; other site 525897005172 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 525897005173 UbiA prenyltransferase family; Region: UbiA; pfam01040 525897005174 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 525897005175 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 525897005176 Cytochrome c; Region: Cytochrom_C; pfam00034 525897005177 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 525897005178 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 525897005179 Subunit I/III interface [polypeptide binding]; other site 525897005180 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 525897005181 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 525897005182 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 525897005183 Cytochrome c; Region: Cytochrom_C; cl11414 525897005184 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 525897005185 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897005186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897005187 active site 525897005188 phosphorylation site [posttranslational modification] 525897005189 intermolecular recognition site; other site 525897005190 dimerization interface [polypeptide binding]; other site 525897005191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897005192 Walker A motif; other site 525897005193 ATP binding site [chemical binding]; other site 525897005194 Walker B motif; other site 525897005195 arginine finger; other site 525897005196 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 525897005197 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 525897005198 hinge; other site 525897005199 active site 525897005200 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 525897005201 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 525897005202 Zn binding site [ion binding]; other site 525897005203 heat shock protein 90; Provisional; Region: PRK05218 525897005204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897005205 ATP binding site [chemical binding]; other site 525897005206 Mg2+ binding site [ion binding]; other site 525897005207 G-X-G motif; other site 525897005208 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525897005209 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525897005210 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897005211 Walker A/P-loop; other site 525897005212 ATP binding site [chemical binding]; other site 525897005213 Q-loop/lid; other site 525897005214 ABC transporter signature motif; other site 525897005215 Walker B; other site 525897005216 D-loop; other site 525897005217 H-loop/switch region; other site 525897005218 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 525897005219 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 525897005220 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 525897005221 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525897005222 catalytic core [active] 525897005223 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 525897005224 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 525897005225 Ligand binding site; other site 525897005226 metal-binding site 525897005227 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897005228 Zn2+ binding site [ion binding]; other site 525897005229 Mg2+ binding site [ion binding]; other site 525897005230 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 525897005231 XdhC Rossmann domain; Region: XdhC_C; pfam13478 525897005232 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525897005233 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 525897005234 acyl-activating enzyme (AAE) consensus motif; other site 525897005235 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525897005236 active site 525897005237 AMP binding site [chemical binding]; other site 525897005238 acyl-activating enzyme (AAE) consensus motif; other site 525897005239 CoA binding site [chemical binding]; other site 525897005240 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525897005241 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897005242 Radical SAM superfamily; Region: Radical_SAM; pfam04055 525897005243 FeS/SAM binding site; other site 525897005244 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 525897005245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897005246 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 525897005247 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525897005248 Cysteine-rich domain; Region: CCG; pfam02754 525897005249 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 525897005250 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 525897005251 catalytic loop [active] 525897005252 iron binding site [ion binding]; other site 525897005253 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 525897005254 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 525897005255 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 525897005256 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 525897005257 putative MPT binding site; other site 525897005258 Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579 525897005259 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 525897005260 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 525897005261 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 525897005262 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 525897005263 putative MPT binding site; other site 525897005264 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 525897005265 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 525897005266 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 525897005267 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 525897005268 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 525897005269 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 525897005270 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 525897005271 [4Fe-4S] binding site [ion binding]; other site 525897005272 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525897005273 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525897005274 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 525897005275 molybdopterin cofactor binding site; other site 525897005276 B12 binding domain; Region: B12-binding; pfam02310 525897005277 B12 binding site [chemical binding]; other site 525897005278 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 525897005279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897005280 FeS/SAM binding site; other site 525897005281 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 525897005282 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 525897005283 putative active site [active] 525897005284 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 525897005285 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 525897005286 Uncharacterized conserved protein [Function unknown]; Region: COG1359 525897005287 KilA-N domain; Region: KilA-N; pfam04383 525897005288 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 525897005289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897005290 dimer interface [polypeptide binding]; other site 525897005291 conserved gate region; other site 525897005292 putative PBP binding loops; other site 525897005293 ABC-ATPase subunit interface; other site 525897005294 cell division protein FtsE; Provisional; Region: PRK10908 525897005295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897005296 Walker A/P-loop; other site 525897005297 ATP binding site [chemical binding]; other site 525897005298 Q-loop/lid; other site 525897005299 ABC transporter signature motif; other site 525897005300 Walker B; other site 525897005301 D-loop; other site 525897005302 H-loop/switch region; other site 525897005303 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 525897005304 active site 525897005305 Int/Topo IB signature motif; other site 525897005306 catalytic residues [active] 525897005307 DNA binding site [nucleotide binding] 525897005308 molybdenum-pterin binding domain; Region: Mop; TIGR00638 525897005309 molybdenum-pterin binding domain; Region: Mop; TIGR00638 525897005310 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 525897005311 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 525897005312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 525897005313 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897005314 dimerization interface [polypeptide binding]; other site 525897005315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897005316 dimer interface [polypeptide binding]; other site 525897005317 phosphorylation site [posttranslational modification] 525897005318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897005319 ATP binding site [chemical binding]; other site 525897005320 Mg2+ binding site [ion binding]; other site 525897005321 G-X-G motif; other site 525897005322 Response regulator receiver domain; Region: Response_reg; pfam00072 525897005323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897005324 active site 525897005325 phosphorylation site [posttranslational modification] 525897005326 intermolecular recognition site; other site 525897005327 dimerization interface [polypeptide binding]; other site 525897005328 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525897005329 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 525897005330 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 525897005331 active site 525897005332 NAD binding site [chemical binding]; other site 525897005333 metal binding site [ion binding]; metal-binding site 525897005334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897005335 PAS domain; Region: PAS_9; pfam13426 525897005336 putative active site [active] 525897005337 heme pocket [chemical binding]; other site 525897005338 SlyX; Region: SlyX; cl01090 525897005339 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 525897005340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897005341 Walker A motif; other site 525897005342 ATP binding site [chemical binding]; other site 525897005343 Walker B motif; other site 525897005344 arginine finger; other site 525897005345 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897005346 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 525897005347 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 525897005348 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 525897005349 dimer interface [polypeptide binding]; other site 525897005350 active site 525897005351 glycine loop; other site 525897005352 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 525897005353 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 525897005354 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 525897005355 DctM-like transporters; Region: DctM; pfam06808 525897005356 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 525897005357 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 525897005358 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525897005359 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 525897005360 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 525897005361 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525897005362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897005363 active site 525897005364 phosphorylation site [posttranslational modification] 525897005365 intermolecular recognition site; other site 525897005366 dimerization interface [polypeptide binding]; other site 525897005367 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525897005368 DNA binding residues [nucleotide binding] 525897005369 dimerization interface [polypeptide binding]; other site 525897005370 PAS domain; Region: PAS_9; pfam13426 525897005371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897005372 putative active site [active] 525897005373 heme pocket [chemical binding]; other site 525897005374 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897005375 Histidine kinase; Region: HisKA_3; pfam07730 525897005376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897005377 ATP binding site [chemical binding]; other site 525897005378 Mg2+ binding site [ion binding]; other site 525897005379 G-X-G motif; other site 525897005380 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 525897005381 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 525897005382 FemAB family; Region: FemAB; pfam02388 525897005383 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 525897005384 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 525897005385 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 525897005386 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 525897005387 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 525897005388 dimer interface [polypeptide binding]; other site 525897005389 active site residues [active] 525897005390 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 525897005391 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 525897005392 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 525897005393 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 525897005394 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 525897005395 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 525897005396 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 525897005397 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 525897005398 active site 525897005399 HIGH motif; other site 525897005400 KMSK motif region; other site 525897005401 tRNA binding surface [nucleotide binding]; other site 525897005402 DALR anticodon binding domain; Region: DALR_1; smart00836 525897005403 anticodon binding site; other site 525897005404 Sporulation related domain; Region: SPOR; pfam05036 525897005405 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 525897005406 agmatinase; Region: agmatinase; TIGR01230 525897005407 putative active site [active] 525897005408 Mn binding site [ion binding]; other site 525897005409 TRAM domain; Region: TRAM; pfam01938 525897005410 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 525897005411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897005412 S-adenosylmethionine binding site [chemical binding]; other site 525897005413 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 525897005414 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 525897005415 acyl-activating enzyme (AAE) consensus motif; other site 525897005416 putative AMP binding site [chemical binding]; other site 525897005417 putative active site [active] 525897005418 putative CoA binding site [chemical binding]; other site 525897005419 Peptidase family M48; Region: Peptidase_M48; cl12018 525897005420 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 525897005421 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 525897005422 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 525897005423 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 525897005424 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 525897005425 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 525897005426 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 525897005427 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 525897005428 putative active site [active] 525897005429 putative triphosphate binding site [ion binding]; other site 525897005430 dimer interface [polypeptide binding]; other site 525897005431 putative metal binding residues [ion binding]; other site 525897005432 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 525897005433 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 525897005434 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 525897005435 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 525897005436 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 525897005437 FeoA domain; Region: FeoA; pfam04023 525897005438 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 525897005439 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 525897005440 G1 box; other site 525897005441 GTP/Mg2+ binding site [chemical binding]; other site 525897005442 Switch I region; other site 525897005443 G2 box; other site 525897005444 G3 box; other site 525897005445 Switch II region; other site 525897005446 G4 box; other site 525897005447 G5 box; other site 525897005448 Nucleoside recognition; Region: Gate; pfam07670 525897005449 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 525897005450 Nucleoside recognition; Region: Gate; pfam07670 525897005451 FeoA domain; Region: FeoA; pfam04023 525897005452 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 525897005453 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 525897005454 Probable Catalytic site; other site 525897005455 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 525897005456 Phosphotransferase enzyme family; Region: APH; pfam01636 525897005457 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 525897005458 active site 525897005459 substrate binding site [chemical binding]; other site 525897005460 ATP binding site [chemical binding]; other site 525897005461 translation initiation factor Sui1; Validated; Region: PRK06824 525897005462 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 525897005463 putative rRNA binding site [nucleotide binding]; other site 525897005464 PAS fold; Region: PAS_3; pfam08447 525897005465 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 525897005466 PAS domain S-box; Region: sensory_box; TIGR00229 525897005467 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897005468 putative active site [active] 525897005469 heme pocket [chemical binding]; other site 525897005470 PAS domain S-box; Region: sensory_box; TIGR00229 525897005471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897005472 putative active site [active] 525897005473 heme pocket [chemical binding]; other site 525897005474 GAF domain; Region: GAF; pfam01590 525897005475 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 525897005476 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 525897005477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897005478 dimer interface [polypeptide binding]; other site 525897005479 phosphorylation site [posttranslational modification] 525897005480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897005481 ATP binding site [chemical binding]; other site 525897005482 Mg2+ binding site [ion binding]; other site 525897005483 G-X-G motif; other site 525897005484 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897005485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897005486 active site 525897005487 phosphorylation site [posttranslational modification] 525897005488 intermolecular recognition site; other site 525897005489 dimerization interface [polypeptide binding]; other site 525897005490 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 525897005491 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 525897005492 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 525897005493 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 525897005494 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 525897005495 putative valine binding site [chemical binding]; other site 525897005496 dimer interface [polypeptide binding]; other site 525897005497 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 525897005498 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 525897005499 PYR/PP interface [polypeptide binding]; other site 525897005500 dimer interface [polypeptide binding]; other site 525897005501 TPP binding site [chemical binding]; other site 525897005502 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 525897005503 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 525897005504 TPP-binding site [chemical binding]; other site 525897005505 dimer interface [polypeptide binding]; other site 525897005506 FAD dependent oxidoreductase; Region: DAO; pfam01266 525897005507 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 525897005508 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525897005509 motif II; other site 525897005510 Ion channel; Region: Ion_trans_2; pfam07885 525897005511 TrkA-N domain; Region: TrkA_N; pfam02254 525897005512 TrkA-C domain; Region: TrkA_C; pfam02080 525897005513 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 525897005514 TrkA-N domain; Region: TrkA_N; pfam02254 525897005515 TrkA-C domain; Region: TrkA_C; pfam02080 525897005516 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 525897005517 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 525897005518 putative active site [active] 525897005519 metal binding site [ion binding]; metal-binding site 525897005520 serine O-acetyltransferase; Region: cysE; TIGR01172 525897005521 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 525897005522 trimer interface [polypeptide binding]; other site 525897005523 active site 525897005524 substrate binding site [chemical binding]; other site 525897005525 CoA binding site [chemical binding]; other site 525897005526 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 525897005527 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 525897005528 dimer interface [polypeptide binding]; other site 525897005529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897005530 catalytic residue [active] 525897005531 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 525897005532 IHF dimer interface [polypeptide binding]; other site 525897005533 IHF - DNA interface [nucleotide binding]; other site 525897005534 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 525897005535 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 525897005536 active site 525897005537 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 525897005538 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 525897005539 active site 525897005540 FMN binding site [chemical binding]; other site 525897005541 substrate binding site [chemical binding]; other site 525897005542 3Fe-4S cluster binding site [ion binding]; other site 525897005543 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 525897005544 domain_subunit interface; other site 525897005545 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 525897005546 PAS domain S-box; Region: sensory_box; TIGR00229 525897005547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897005548 putative active site [active] 525897005549 heme pocket [chemical binding]; other site 525897005550 PAS domain S-box; Region: sensory_box; TIGR00229 525897005551 PAS domain; Region: PAS_9; pfam13426 525897005552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897005553 putative active site [active] 525897005554 heme pocket [chemical binding]; other site 525897005555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897005556 PAS fold; Region: PAS_3; pfam08447 525897005557 putative active site [active] 525897005558 heme pocket [chemical binding]; other site 525897005559 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897005560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897005561 dimer interface [polypeptide binding]; other site 525897005562 phosphorylation site [posttranslational modification] 525897005563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897005564 ATP binding site [chemical binding]; other site 525897005565 Mg2+ binding site [ion binding]; other site 525897005566 G-X-G motif; other site 525897005567 Response regulator receiver domain; Region: Response_reg; pfam00072 525897005568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897005569 active site 525897005570 phosphorylation site [posttranslational modification] 525897005571 intermolecular recognition site; other site 525897005572 dimerization interface [polypeptide binding]; other site 525897005573 Predicted metalloprotease [General function prediction only]; Region: COG2321 525897005574 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 525897005575 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 525897005576 PIN domain; Region: PIN_3; pfam13470 525897005577 Fic family protein [Function unknown]; Region: COG3177 525897005578 Fic/DOC family; Region: Fic; pfam02661 525897005579 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 525897005580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525897005581 Coenzyme A binding pocket [chemical binding]; other site 525897005582 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 525897005583 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 525897005584 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 525897005585 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 525897005586 active site 525897005587 NTP binding site [chemical binding]; other site 525897005588 metal binding triad [ion binding]; metal-binding site 525897005589 EAP30/Vps36 family; Region: EAP30; pfam04157 525897005590 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 525897005591 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 525897005592 C-terminal peptidase (prc); Region: prc; TIGR00225 525897005593 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 525897005594 protein binding site [polypeptide binding]; other site 525897005595 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 525897005596 Active site serine [active] 525897005597 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 525897005598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897005599 Walker A/P-loop; other site 525897005600 ATP binding site [chemical binding]; other site 525897005601 ABC transporter; Region: ABC_tran; pfam00005 525897005602 Q-loop/lid; other site 525897005603 ABC transporter signature motif; other site 525897005604 Walker B; other site 525897005605 D-loop; other site 525897005606 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 525897005607 metal ion-dependent adhesion site (MIDAS); other site 525897005608 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 525897005609 FtsX-like permease family; Region: FtsX; pfam02687 525897005610 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525897005611 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525897005612 Walker A/P-loop; other site 525897005613 ATP binding site [chemical binding]; other site 525897005614 Q-loop/lid; other site 525897005615 ABC transporter signature motif; other site 525897005616 Walker B; other site 525897005617 D-loop; other site 525897005618 H-loop/switch region; other site 525897005619 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 525897005620 active site 525897005621 catalytic triad [active] 525897005622 oxyanion hole [active] 525897005623 switch loop; other site 525897005624 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525897005625 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 525897005626 active site 525897005627 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525897005628 active site residue [active] 525897005629 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 525897005630 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 525897005631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525897005632 putative substrate translocation pore; other site 525897005633 Major Facilitator Superfamily; Region: MFS_1; pfam07690 525897005634 PilZ domain; Region: PilZ; pfam07238 525897005635 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 525897005636 oligomerization interface [polypeptide binding]; other site 525897005637 active site 525897005638 metal binding site [ion binding]; metal-binding site 525897005639 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 525897005640 tetramerization interface [polypeptide binding]; other site 525897005641 active site 525897005642 Pantoate-beta-alanine ligase; Region: PanC; cd00560 525897005643 pantoate--beta-alanine ligase; Region: panC; TIGR00018 525897005644 active site 525897005645 ATP-binding site [chemical binding]; other site 525897005646 pantoate-binding site; other site 525897005647 HXXH motif; other site 525897005648 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 525897005649 ABC transporter ATPase component; Reviewed; Region: PRK11147 525897005650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897005651 Walker A/P-loop; other site 525897005652 ATP binding site [chemical binding]; other site 525897005653 Q-loop/lid; other site 525897005654 ABC transporter signature motif; other site 525897005655 Walker B; other site 525897005656 D-loop; other site 525897005657 H-loop/switch region; other site 525897005658 ABC transporter; Region: ABC_tran_2; pfam12848 525897005659 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525897005660 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 525897005661 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 525897005662 putative FMN binding site [chemical binding]; other site 525897005663 NADPH bind site [chemical binding]; other site 525897005664 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 525897005665 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 525897005666 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 525897005667 acyl-activating enzyme (AAE) consensus motif; other site 525897005668 putative AMP binding site [chemical binding]; other site 525897005669 putative active site [active] 525897005670 putative CoA binding site [chemical binding]; other site 525897005671 O-Antigen ligase; Region: Wzy_C; pfam04932 525897005672 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 525897005673 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 525897005674 HSP70 interaction site [polypeptide binding]; other site 525897005675 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 525897005676 Chain length determinant protein; Region: Wzz; pfam02706 525897005677 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 525897005678 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525897005679 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 525897005680 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 525897005681 SLBB domain; Region: SLBB; pfam10531 525897005682 SLBB domain; Region: SLBB; pfam10531 525897005683 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 525897005684 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 525897005685 Bacterial sugar transferase; Region: Bac_transf; pfam02397 525897005686 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 525897005687 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525897005688 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897005689 O-Antigen ligase; Region: Wzy_C; pfam04932 525897005690 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897005691 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 525897005692 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 525897005693 Peptidase family M23; Region: Peptidase_M23; pfam01551 525897005694 DctM-like transporters; Region: DctM; pfam06808 525897005695 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 525897005696 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 525897005697 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 525897005698 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 525897005699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525897005700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525897005701 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 525897005702 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 525897005703 active site 525897005704 C-terminal domain interface [polypeptide binding]; other site 525897005705 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 525897005706 active site 525897005707 N-terminal domain interface [polypeptide binding]; other site 525897005708 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 525897005709 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525897005710 ABC-ATPase subunit interface; other site 525897005711 dimer interface [polypeptide binding]; other site 525897005712 putative PBP binding regions; other site 525897005713 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 525897005714 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 525897005715 Walker A/P-loop; other site 525897005716 ATP binding site [chemical binding]; other site 525897005717 Q-loop/lid; other site 525897005718 ABC transporter signature motif; other site 525897005719 Walker B; other site 525897005720 D-loop; other site 525897005721 H-loop/switch region; other site 525897005722 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 525897005723 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525897005724 intersubunit interface [polypeptide binding]; other site 525897005725 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 525897005726 active site 525897005727 SAM binding site [chemical binding]; other site 525897005728 homodimer interface [polypeptide binding]; other site 525897005729 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 525897005730 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 525897005731 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 525897005732 catalytic triad [active] 525897005733 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 525897005734 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 525897005735 active site 525897005736 putative homodimer interface [polypeptide binding]; other site 525897005737 SAM binding site [chemical binding]; other site 525897005738 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 525897005739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897005740 S-adenosylmethionine binding site [chemical binding]; other site 525897005741 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 525897005742 active site 525897005743 SAM binding site [chemical binding]; other site 525897005744 homodimer interface [polypeptide binding]; other site 525897005745 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 525897005746 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 525897005747 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 525897005748 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 525897005749 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 525897005750 active site 525897005751 SAM binding site [chemical binding]; other site 525897005752 homodimer interface [polypeptide binding]; other site 525897005753 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897005754 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 525897005755 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897005756 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897005757 metal binding site [ion binding]; metal-binding site 525897005758 active site 525897005759 I-site; other site 525897005760 DctM-like transporters; Region: DctM; pfam06808 525897005761 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 525897005762 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 525897005763 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 525897005764 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 525897005765 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 525897005766 FAD binding domain; Region: FAD_binding_4; pfam01565 525897005767 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525897005768 Cupin domain; Region: Cupin_2; pfam07883 525897005769 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 525897005770 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 525897005771 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 525897005772 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525897005773 Cysteine-rich domain; Region: CCG; pfam02754 525897005774 Cysteine-rich domain; Region: CCG; pfam02754 525897005775 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 525897005776 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 525897005777 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 525897005778 GIY-YIG motif/motif A; other site 525897005779 putative active site [active] 525897005780 putative metal binding site [ion binding]; other site 525897005781 Haemolysin-III related; Region: HlyIII; cl03831 525897005782 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 525897005783 LabA_like proteins; Region: LabA_like; cd06167 525897005784 putative metal binding site [ion binding]; other site 525897005785 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 525897005786 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 525897005787 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 525897005788 active site 525897005789 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 525897005790 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897005791 FeS/SAM binding site; other site 525897005792 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 525897005793 chaperone protein DnaJ; Provisional; Region: PRK14299 525897005794 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 525897005795 HSP70 interaction site [polypeptide binding]; other site 525897005796 elongation factor G; Reviewed; Region: PRK12739 525897005797 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 525897005798 G1 box; other site 525897005799 putative GEF interaction site [polypeptide binding]; other site 525897005800 GTP/Mg2+ binding site [chemical binding]; other site 525897005801 Switch I region; other site 525897005802 G2 box; other site 525897005803 G3 box; other site 525897005804 Switch II region; other site 525897005805 G4 box; other site 525897005806 G5 box; other site 525897005807 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 525897005808 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 525897005809 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 525897005810 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 525897005811 tartrate dehydrogenase; Region: TTC; TIGR02089 525897005812 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 525897005813 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 525897005814 substrate binding site [chemical binding]; other site 525897005815 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 525897005816 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 525897005817 substrate binding site [chemical binding]; other site 525897005818 ligand binding site [chemical binding]; other site 525897005819 2-isopropylmalate synthase; Validated; Region: PRK00915 525897005820 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 525897005821 active site 525897005822 catalytic residues [active] 525897005823 metal binding site [ion binding]; metal-binding site 525897005824 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 525897005825 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 525897005826 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 525897005827 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 525897005828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 525897005829 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 525897005830 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 525897005831 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 525897005832 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525897005833 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 525897005834 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 525897005835 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 525897005836 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 525897005837 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 525897005838 tRNA; other site 525897005839 putative tRNA binding site [nucleotide binding]; other site 525897005840 putative NADP binding site [chemical binding]; other site 525897005841 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 525897005842 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 525897005843 Ligand Binding Site [chemical binding]; other site 525897005844 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 525897005845 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 525897005846 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 525897005847 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 525897005848 catalytic residues [active] 525897005849 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 525897005850 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 525897005851 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525897005852 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 525897005853 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897005854 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 525897005855 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 525897005856 homodimer interface [polypeptide binding]; other site 525897005857 substrate-cofactor binding pocket; other site 525897005858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897005859 catalytic residue [active] 525897005860 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 525897005861 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 525897005862 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 525897005863 FAD binding site [chemical binding]; other site 525897005864 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 525897005865 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 525897005866 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 525897005867 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 525897005868 active site 525897005869 8-oxo-dGMP binding site [chemical binding]; other site 525897005870 nudix motif; other site 525897005871 metal binding site [ion binding]; metal-binding site 525897005872 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 525897005873 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525897005874 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525897005875 ABC transporter; Region: ABC_tran_2; pfam12848 525897005876 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525897005877 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 525897005878 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 525897005879 active site 525897005880 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 525897005881 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 525897005882 minor groove reading motif; other site 525897005883 helix-hairpin-helix signature motif; other site 525897005884 substrate binding pocket [chemical binding]; other site 525897005885 active site 525897005886 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 525897005887 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 525897005888 active site 525897005889 8-oxo-dGMP binding site [chemical binding]; other site 525897005890 nudix motif; other site 525897005891 metal binding site [ion binding]; metal-binding site 525897005892 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 525897005893 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 525897005894 nucleophilic elbow; other site 525897005895 catalytic triad; other site 525897005896 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 525897005897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897005898 dimer interface [polypeptide binding]; other site 525897005899 conserved gate region; other site 525897005900 putative PBP binding loops; other site 525897005901 ABC-ATPase subunit interface; other site 525897005902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897005903 dimer interface [polypeptide binding]; other site 525897005904 conserved gate region; other site 525897005905 putative PBP binding loops; other site 525897005906 ABC-ATPase subunit interface; other site 525897005907 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 525897005908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897005909 Walker A/P-loop; other site 525897005910 ATP binding site [chemical binding]; other site 525897005911 Q-loop/lid; other site 525897005912 ABC transporter signature motif; other site 525897005913 Walker B; other site 525897005914 D-loop; other site 525897005915 H-loop/switch region; other site 525897005916 TOBE domain; Region: TOBE_2; pfam08402 525897005917 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 525897005918 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 525897005919 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897005920 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897005921 dimer interface [polypeptide binding]; other site 525897005922 phosphorylation site [posttranslational modification] 525897005923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897005924 ATP binding site [chemical binding]; other site 525897005925 Mg2+ binding site [ion binding]; other site 525897005926 G-X-G motif; other site 525897005927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897005928 Response regulator receiver domain; Region: Response_reg; pfam00072 525897005929 active site 525897005930 phosphorylation site [posttranslational modification] 525897005931 intermolecular recognition site; other site 525897005932 dimerization interface [polypeptide binding]; other site 525897005933 Acyltransferase family; Region: Acyl_transf_3; pfam01757 525897005934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525897005935 Coenzyme A binding pocket [chemical binding]; other site 525897005936 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 525897005937 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525897005938 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 525897005939 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525897005940 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 525897005941 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897005942 FeS/SAM binding site; other site 525897005943 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 525897005944 DnaJ_C chaperone protein; Provisional; Region: PTZ00037 525897005945 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 525897005946 active site 525897005947 substrate binding pocket [chemical binding]; other site 525897005948 dimer interface [polypeptide binding]; other site 525897005949 Predicted membrane protein [Function unknown]; Region: COG1238 525897005950 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 525897005951 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 525897005952 FMN binding site [chemical binding]; other site 525897005953 active site 525897005954 catalytic residues [active] 525897005955 substrate binding site [chemical binding]; other site 525897005956 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 525897005957 Protein export membrane protein; Region: SecD_SecF; cl14618 525897005958 Domain of unknown function (DUF4203); Region: DUF4203; pfam13886 525897005959 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 525897005960 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897005961 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 525897005962 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 525897005963 Substrate binding site; other site 525897005964 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 525897005965 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525897005966 active site residue [active] 525897005967 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 525897005968 diiron binding motif [ion binding]; other site 525897005969 Uncharacterized conserved protein [Function unknown]; Region: COG2006 525897005970 Domain of unknown function (DUF362); Region: DUF362; pfam04015 525897005971 Acylphosphatase; Region: Acylphosphatase; pfam00708 525897005972 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 525897005973 HypF finger; Region: zf-HYPF; pfam07503 525897005974 HypF finger; Region: zf-HYPF; pfam07503 525897005975 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 525897005976 protease 4; Provisional; Region: PRK10949 525897005977 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 525897005978 tandem repeat interface [polypeptide binding]; other site 525897005979 oligomer interface [polypeptide binding]; other site 525897005980 active site residues [active] 525897005981 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 525897005982 tandem repeat interface [polypeptide binding]; other site 525897005983 oligomer interface [polypeptide binding]; other site 525897005984 active site residues [active] 525897005985 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 525897005986 FAD binding domain; Region: FAD_binding_4; pfam01565 525897005987 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 525897005988 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525897005989 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897005990 Cysteine-rich domain; Region: CCG; pfam02754 525897005991 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 525897005992 YceG-like family; Region: YceG; pfam02618 525897005993 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 525897005994 dimerization interface [polypeptide binding]; other site 525897005995 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 525897005996 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 525897005997 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 525897005998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897005999 dimer interface [polypeptide binding]; other site 525897006000 conserved gate region; other site 525897006001 putative PBP binding loops; other site 525897006002 ABC-ATPase subunit interface; other site 525897006003 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 525897006004 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 525897006005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897006006 dimer interface [polypeptide binding]; other site 525897006007 conserved gate region; other site 525897006008 putative PBP binding loops; other site 525897006009 ABC-ATPase subunit interface; other site 525897006010 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 525897006011 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525897006012 Walker A/P-loop; other site 525897006013 ATP binding site [chemical binding]; other site 525897006014 Q-loop/lid; other site 525897006015 ABC transporter signature motif; other site 525897006016 Walker B; other site 525897006017 D-loop; other site 525897006018 H-loop/switch region; other site 525897006019 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 525897006020 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 525897006021 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525897006022 Walker A/P-loop; other site 525897006023 ATP binding site [chemical binding]; other site 525897006024 Q-loop/lid; other site 525897006025 ABC transporter signature motif; other site 525897006026 Walker B; other site 525897006027 D-loop; other site 525897006028 H-loop/switch region; other site 525897006029 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 525897006030 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 525897006031 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 525897006032 Cache domain; Region: Cache_1; pfam02743 525897006033 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897006034 dimerization interface [polypeptide binding]; other site 525897006035 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897006036 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525897006037 dimer interface [polypeptide binding]; other site 525897006038 putative CheW interface [polypeptide binding]; other site 525897006039 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 525897006040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525897006041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525897006042 Predicted permeases [General function prediction only]; Region: COG0795 525897006043 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 525897006044 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 525897006045 Predicted permeases [General function prediction only]; Region: COG0795 525897006046 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 525897006047 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 525897006048 Competence protein; Region: Competence; pfam03772 525897006049 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525897006050 Response regulator receiver domain; Region: Response_reg; pfam00072 525897006051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006052 active site 525897006053 phosphorylation site [posttranslational modification] 525897006054 intermolecular recognition site; other site 525897006055 dimerization interface [polypeptide binding]; other site 525897006056 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 525897006057 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 525897006058 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 525897006059 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 525897006060 Walker A/P-loop; other site 525897006061 ATP binding site [chemical binding]; other site 525897006062 Q-loop/lid; other site 525897006063 ABC transporter signature motif; other site 525897006064 Walker B; other site 525897006065 D-loop; other site 525897006066 H-loop/switch region; other site 525897006067 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 525897006068 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525897006069 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525897006070 RNA binding surface [nucleotide binding]; other site 525897006071 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 525897006072 active site 525897006073 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 525897006074 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 525897006075 CoA-binding site [chemical binding]; other site 525897006076 ATP-binding [chemical binding]; other site 525897006077 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 525897006078 metal ion-dependent adhesion site (MIDAS); other site 525897006079 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 525897006080 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 525897006081 ligand binding site [chemical binding]; other site 525897006082 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 525897006083 active site 525897006084 DNA polymerase IV; Validated; Region: PRK02406 525897006085 DNA binding site [nucleotide binding] 525897006086 Amidinotransferase; Region: Amidinotransf; pfam02274 525897006087 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525897006088 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525897006089 substrate binding pocket [chemical binding]; other site 525897006090 membrane-bound complex binding site; other site 525897006091 hinge residues; other site 525897006092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897006093 dimer interface [polypeptide binding]; other site 525897006094 conserved gate region; other site 525897006095 putative PBP binding loops; other site 525897006096 ABC-ATPase subunit interface; other site 525897006097 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525897006098 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 525897006099 Walker A/P-loop; other site 525897006100 ATP binding site [chemical binding]; other site 525897006101 Q-loop/lid; other site 525897006102 ABC transporter signature motif; other site 525897006103 Walker B; other site 525897006104 D-loop; other site 525897006105 H-loop/switch region; other site 525897006106 4Fe-4S binding domain; Region: Fer4_6; pfam12837 525897006107 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 525897006108 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 525897006109 EamA-like transporter family; Region: EamA; pfam00892 525897006110 EamA-like transporter family; Region: EamA; pfam00892 525897006111 AAA domain; Region: AAA_22; pfam13401 525897006112 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525897006113 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 525897006114 acyl-activating enzyme (AAE) consensus motif; other site 525897006115 AMP binding site [chemical binding]; other site 525897006116 active site 525897006117 CoA binding site [chemical binding]; other site 525897006118 replicative DNA helicase; Region: DnaB; TIGR00665 525897006119 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 525897006120 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 525897006121 Walker A motif; other site 525897006122 ATP binding site [chemical binding]; other site 525897006123 Walker B motif; other site 525897006124 DNA binding loops [nucleotide binding] 525897006125 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 525897006126 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 525897006127 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 525897006128 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 525897006129 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 525897006130 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897006131 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897006132 putative active site [active] 525897006133 heme pocket [chemical binding]; other site 525897006134 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897006135 dimer interface [polypeptide binding]; other site 525897006136 phosphorylation site [posttranslational modification] 525897006137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897006138 ATP binding site [chemical binding]; other site 525897006139 G-X-G motif; other site 525897006140 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897006141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006142 active site 525897006143 phosphorylation site [posttranslational modification] 525897006144 intermolecular recognition site; other site 525897006145 dimerization interface [polypeptide binding]; other site 525897006146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897006147 Walker A motif; other site 525897006148 ATP binding site [chemical binding]; other site 525897006149 Walker B motif; other site 525897006150 arginine finger; other site 525897006151 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897006152 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897006153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006154 active site 525897006155 phosphorylation site [posttranslational modification] 525897006156 intermolecular recognition site; other site 525897006157 dimerization interface [polypeptide binding]; other site 525897006158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897006159 Walker A motif; other site 525897006160 ATP binding site [chemical binding]; other site 525897006161 Walker B motif; other site 525897006162 arginine finger; other site 525897006163 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897006164 dimerization interface [polypeptide binding]; other site 525897006165 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897006166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 525897006167 putative active site [active] 525897006168 heme pocket [chemical binding]; other site 525897006169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897006170 dimer interface [polypeptide binding]; other site 525897006171 phosphorylation site [posttranslational modification] 525897006172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897006173 ATP binding site [chemical binding]; other site 525897006174 Mg2+ binding site [ion binding]; other site 525897006175 G-X-G motif; other site 525897006176 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 525897006177 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 525897006178 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 525897006179 CoA-ligase; Region: Ligase_CoA; pfam00549 525897006180 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 525897006181 CoA binding domain; Region: CoA_binding; smart00881 525897006182 CoA-ligase; Region: Ligase_CoA; pfam00549 525897006183 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 525897006184 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 525897006185 active site 525897006186 catalytic motif [active] 525897006187 Zn binding site [ion binding]; other site 525897006188 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 525897006189 Amidase; Region: Amidase; cl11426 525897006190 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 525897006191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897006192 putative PBP binding loops; other site 525897006193 dimer interface [polypeptide binding]; other site 525897006194 ABC-ATPase subunit interface; other site 525897006195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897006196 dimer interface [polypeptide binding]; other site 525897006197 conserved gate region; other site 525897006198 putative PBP binding loops; other site 525897006199 ABC-ATPase subunit interface; other site 525897006200 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 525897006201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897006202 Walker A/P-loop; other site 525897006203 ATP binding site [chemical binding]; other site 525897006204 Q-loop/lid; other site 525897006205 ABC transporter signature motif; other site 525897006206 Walker B; other site 525897006207 D-loop; other site 525897006208 H-loop/switch region; other site 525897006209 TOBE domain; Region: TOBE_2; pfam08402 525897006210 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 525897006211 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 525897006212 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 525897006213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 525897006214 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 525897006215 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 525897006216 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 525897006217 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 525897006218 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 525897006219 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 525897006220 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 525897006221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897006222 dimer interface [polypeptide binding]; other site 525897006223 conserved gate region; other site 525897006224 putative PBP binding loops; other site 525897006225 ABC-ATPase subunit interface; other site 525897006226 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 525897006227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897006228 dimer interface [polypeptide binding]; other site 525897006229 conserved gate region; other site 525897006230 putative PBP binding loops; other site 525897006231 ABC-ATPase subunit interface; other site 525897006232 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 525897006233 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 525897006234 Walker A/P-loop; other site 525897006235 ATP binding site [chemical binding]; other site 525897006236 Q-loop/lid; other site 525897006237 ABC transporter signature motif; other site 525897006238 Walker B; other site 525897006239 D-loop; other site 525897006240 H-loop/switch region; other site 525897006241 TOBE domain; Region: TOBE_2; pfam08402 525897006242 Uncharacterized conserved protein [Function unknown]; Region: COG0062 525897006243 putative carbohydrate kinase; Provisional; Region: PRK10565 525897006244 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 525897006245 putative substrate binding site [chemical binding]; other site 525897006246 putative ATP binding site [chemical binding]; other site 525897006247 FOG: CBS domain [General function prediction only]; Region: COG0517 525897006248 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 525897006249 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 525897006250 recombination factor protein RarA; Reviewed; Region: PRK13342 525897006251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897006252 Walker A motif; other site 525897006253 ATP binding site [chemical binding]; other site 525897006254 Walker B motif; other site 525897006255 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 525897006256 DNA repair protein RadA; Provisional; Region: PRK11823 525897006257 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 525897006258 Walker A motif; other site 525897006259 ATP binding site [chemical binding]; other site 525897006260 Walker B motif; other site 525897006261 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 525897006262 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 525897006263 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525897006264 active site 525897006265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525897006266 Coenzyme A binding pocket [chemical binding]; other site 525897006267 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 525897006268 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 525897006269 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 525897006270 substrate binding pocket [chemical binding]; other site 525897006271 dimer interface [polypeptide binding]; other site 525897006272 inhibitor binding site; inhibition site 525897006273 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 525897006274 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 525897006275 B12 binding site [chemical binding]; other site 525897006276 cobalt ligand [ion binding]; other site 525897006277 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 525897006278 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 525897006279 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 525897006280 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 525897006281 DNA binding residues [nucleotide binding] 525897006282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897006283 binding surface 525897006284 Tetratricopeptide repeat; Region: TPR_16; pfam13432 525897006285 TPR motif; other site 525897006286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897006287 TPR motif; other site 525897006288 binding surface 525897006289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897006290 binding surface 525897006291 TPR motif; other site 525897006292 TPR repeat; Region: TPR_11; pfam13414 525897006293 TPR repeat; Region: TPR_11; pfam13414 525897006294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897006295 binding surface 525897006296 TPR motif; other site 525897006297 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 525897006298 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 525897006299 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 525897006300 TPP-binding site [chemical binding]; other site 525897006301 dimer interface [polypeptide binding]; other site 525897006302 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 525897006303 PYR/PP interface [polypeptide binding]; other site 525897006304 dimer interface [polypeptide binding]; other site 525897006305 TPP binding site [chemical binding]; other site 525897006306 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 525897006307 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 525897006308 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 525897006309 putative active site [active] 525897006310 Sulphur transport; Region: Sulf_transp; pfam04143 525897006311 Sulphur transport; Region: Sulf_transp; pfam04143 525897006312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525897006313 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 525897006314 NAD(P) binding site [chemical binding]; other site 525897006315 active site 525897006316 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 525897006317 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 525897006318 Methyltransferase domain; Region: Methyltransf_23; pfam13489 525897006319 Methyltransferase domain; Region: Methyltransf_12; pfam08242 525897006320 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 525897006321 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 525897006322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525897006323 NAD(P) binding site [chemical binding]; other site 525897006324 active site 525897006325 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 525897006326 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 525897006327 substrate binding site; other site 525897006328 TPR repeat; Region: TPR_11; pfam13414 525897006329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897006330 binding surface 525897006331 TPR motif; other site 525897006332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897006333 TPR motif; other site 525897006334 binding surface 525897006335 TPR repeat; Region: TPR_11; pfam13414 525897006336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897006337 binding surface 525897006338 TPR motif; other site 525897006339 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 525897006340 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 525897006341 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 525897006342 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 525897006343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897006344 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897006345 dimer interface [polypeptide binding]; other site 525897006346 phosphorylation site [posttranslational modification] 525897006347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897006348 ATP binding site [chemical binding]; other site 525897006349 Mg2+ binding site [ion binding]; other site 525897006350 G-X-G motif; other site 525897006351 Response regulator receiver domain; Region: Response_reg; pfam00072 525897006352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006353 active site 525897006354 phosphorylation site [posttranslational modification] 525897006355 intermolecular recognition site; other site 525897006356 dimerization interface [polypeptide binding]; other site 525897006357 Response regulator receiver domain; Region: Response_reg; pfam00072 525897006358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006359 active site 525897006360 phosphorylation site [posttranslational modification] 525897006361 intermolecular recognition site; other site 525897006362 dimerization interface [polypeptide binding]; other site 525897006363 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 525897006364 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 525897006365 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 525897006366 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 525897006367 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 525897006368 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 525897006369 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 525897006370 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 525897006371 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 525897006372 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 525897006373 putative active site [active] 525897006374 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 525897006375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525897006376 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 525897006377 Walker A/P-loop; other site 525897006378 ATP binding site [chemical binding]; other site 525897006379 Q-loop/lid; other site 525897006380 ABC transporter signature motif; other site 525897006381 Walker B; other site 525897006382 D-loop; other site 525897006383 H-loop/switch region; other site 525897006384 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 525897006385 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897006386 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525897006387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006388 active site 525897006389 phosphorylation site [posttranslational modification] 525897006390 intermolecular recognition site; other site 525897006391 dimerization interface [polypeptide binding]; other site 525897006392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525897006393 DNA binding residues [nucleotide binding] 525897006394 dimerization interface [polypeptide binding]; other site 525897006395 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525897006396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006397 active site 525897006398 phosphorylation site [posttranslational modification] 525897006399 intermolecular recognition site; other site 525897006400 dimerization interface [polypeptide binding]; other site 525897006401 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525897006402 DNA binding residues [nucleotide binding] 525897006403 dimerization interface [polypeptide binding]; other site 525897006404 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 525897006405 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525897006406 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 525897006407 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 525897006408 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 525897006409 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 525897006410 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 525897006411 transmembrane helices; other site 525897006412 TrkA-C domain; Region: TrkA_C; pfam02080 525897006413 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 525897006414 TrkA-C domain; Region: TrkA_C; pfam02080 525897006415 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 525897006416 BCCT family transporter; Region: BCCT; pfam02028 525897006417 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 525897006418 homodimer interaction site [polypeptide binding]; other site 525897006419 cofactor binding site; other site 525897006420 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 525897006421 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 525897006422 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 525897006423 lytic murein transglycosylase; Provisional; Region: PRK11619 525897006424 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 525897006425 N-acetyl-D-glucosamine binding site [chemical binding]; other site 525897006426 catalytic residue [active] 525897006427 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525897006428 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525897006429 Walker A/P-loop; other site 525897006430 ATP binding site [chemical binding]; other site 525897006431 Q-loop/lid; other site 525897006432 ABC transporter signature motif; other site 525897006433 Walker B; other site 525897006434 D-loop; other site 525897006435 H-loop/switch region; other site 525897006436 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 525897006437 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525897006438 Poxvirus P4B major core protein; Region: Pox_P4B; pfam03292 525897006439 FtsX-like permease family; Region: FtsX; pfam02687 525897006440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897006441 binding surface 525897006442 TPR motif; other site 525897006443 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 525897006444 PAS domain S-box; Region: sensory_box; TIGR00229 525897006445 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897006446 putative active site [active] 525897006447 heme pocket [chemical binding]; other site 525897006448 PAS domain S-box; Region: sensory_box; TIGR00229 525897006449 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897006450 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897006451 metal binding site [ion binding]; metal-binding site 525897006452 active site 525897006453 I-site; other site 525897006454 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525897006455 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 525897006456 active site residue [active] 525897006457 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 525897006458 Predicted permease; Region: DUF318; cl17795 525897006459 Predicted permease; Region: DUF318; cl17795 525897006460 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525897006461 dimerization interface [polypeptide binding]; other site 525897006462 putative DNA binding site [nucleotide binding]; other site 525897006463 putative Zn2+ binding site [ion binding]; other site 525897006464 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525897006465 putative DNA binding site [nucleotide binding]; other site 525897006466 dimerization interface [polypeptide binding]; other site 525897006467 putative Zn2+ binding site [ion binding]; other site 525897006468 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 525897006469 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 525897006470 catalytic residues [active] 525897006471 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 525897006472 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 525897006473 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 525897006474 Sodium Bile acid symporter family; Region: SBF; cl17470 525897006475 Low molecular weight phosphatase family; Region: LMWPc; cd00115 525897006476 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 525897006477 active site 525897006478 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 525897006479 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 525897006480 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 525897006481 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 525897006482 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525897006483 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897006484 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 525897006485 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 525897006486 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897006487 dimerization interface [polypeptide binding]; other site 525897006488 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897006489 dimer interface [polypeptide binding]; other site 525897006490 putative CheW interface [polypeptide binding]; other site 525897006491 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 525897006492 putative CheA interaction surface; other site 525897006493 hybrid cluster protein; Provisional; Region: PRK05290 525897006494 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897006495 ACS interaction site; other site 525897006496 CODH interaction site; other site 525897006497 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 525897006498 hybrid metal cluster; other site 525897006499 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 525897006500 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525897006501 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 525897006502 HPP family; Region: HPP; pfam04982 525897006503 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 525897006504 FOG: CBS domain [General function prediction only]; Region: COG0517 525897006505 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 525897006506 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525897006507 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525897006508 Walker A/P-loop; other site 525897006509 ATP binding site [chemical binding]; other site 525897006510 Q-loop/lid; other site 525897006511 ABC transporter signature motif; other site 525897006512 Walker B; other site 525897006513 D-loop; other site 525897006514 H-loop/switch region; other site 525897006515 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525897006516 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 525897006517 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897006518 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525897006519 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525897006520 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 525897006521 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 525897006522 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 525897006523 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897006524 HAMP domain; Region: HAMP; pfam00672 525897006525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897006526 dimer interface [polypeptide binding]; other site 525897006527 phosphorylation site [posttranslational modification] 525897006528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897006529 ATP binding site [chemical binding]; other site 525897006530 Mg2+ binding site [ion binding]; other site 525897006531 G-X-G motif; other site 525897006532 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525897006533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006534 active site 525897006535 phosphorylation site [posttranslational modification] 525897006536 intermolecular recognition site; other site 525897006537 dimerization interface [polypeptide binding]; other site 525897006538 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525897006539 DNA binding site [nucleotide binding] 525897006540 Sulfatase; Region: Sulfatase; pfam00884 525897006541 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 525897006542 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 525897006543 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897006544 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525897006545 dimerization interface [polypeptide binding]; other site 525897006546 putative DNA binding site [nucleotide binding]; other site 525897006547 putative Zn2+ binding site [ion binding]; other site 525897006548 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 525897006549 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 525897006550 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 525897006551 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525897006552 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 525897006553 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 525897006554 transmembrane helices; other site 525897006555 TrkA-C domain; Region: TrkA_C; pfam02080 525897006556 TrkA-C domain; Region: TrkA_C; pfam02080 525897006557 TrkA-C domain; Region: TrkA_C; pfam02080 525897006558 TrkA-C domain; Region: TrkA_C; pfam02080 525897006559 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 525897006560 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 525897006561 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 525897006562 Uncharacterized conserved protein [Function unknown]; Region: COG0327 525897006563 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 525897006564 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 525897006565 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 525897006566 Putative zinc ribbon domain; Region: DUF164; pfam02591 525897006567 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 525897006568 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 525897006569 substrate binding site; other site 525897006570 dimer interface; other site 525897006571 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 525897006572 homotrimer interaction site [polypeptide binding]; other site 525897006573 zinc binding site [ion binding]; other site 525897006574 CDP-binding sites; other site 525897006575 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525897006576 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 525897006577 active site 525897006578 HIGH motif; other site 525897006579 nucleotide binding site [chemical binding]; other site 525897006580 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 525897006581 active site 525897006582 KMSKS motif; other site 525897006583 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 525897006584 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 525897006585 active site 525897006586 HIGH motif; other site 525897006587 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 525897006588 KMSKS motif; other site 525897006589 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 525897006590 tRNA binding surface [nucleotide binding]; other site 525897006591 anticodon binding site; other site 525897006592 AsmA family; Region: AsmA; pfam05170 525897006593 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 525897006594 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 525897006595 ApbE family; Region: ApbE; pfam02424 525897006596 ferredoxin; Validated; Region: PRK07118 525897006597 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897006598 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 525897006599 electron transport complex RsxE subunit; Provisional; Region: PRK12405 525897006600 FMN-binding domain; Region: FMN_bind; cl01081 525897006601 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 525897006602 SLBB domain; Region: SLBB; pfam10531 525897006603 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897006604 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 525897006605 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525897006606 heme-binding residues [chemical binding]; other site 525897006607 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525897006608 heme-binding residues [chemical binding]; other site 525897006609 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525897006610 heme-binding residues [chemical binding]; other site 525897006611 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 525897006612 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 525897006613 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 525897006614 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 525897006615 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 525897006616 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 525897006617 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 525897006618 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 525897006619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525897006620 ATP-grasp domain; Region: ATP-grasp; pfam02222 525897006621 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 525897006622 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 525897006623 nickel binding site [ion binding]; other site 525897006624 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 525897006625 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 525897006626 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 525897006627 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 525897006628 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 525897006629 Transcriptional regulators [Transcription]; Region: FadR; COG2186 525897006630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525897006631 DNA-binding site [nucleotide binding]; DNA binding site 525897006632 FCD domain; Region: FCD; pfam07729 525897006633 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 525897006634 active site 525897006635 substrate binding site [chemical binding]; other site 525897006636 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 525897006637 FMN binding site [chemical binding]; other site 525897006638 putative catalytic residues [active] 525897006639 PilZ domain; Region: PilZ; pfam07238 525897006640 PilZ domain; Region: PilZ; pfam07238 525897006641 Transcriptional regulators [Transcription]; Region: GntR; COG1802 525897006642 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525897006643 DNA-binding site [nucleotide binding]; DNA binding site 525897006644 FCD domain; Region: FCD; pfam07729 525897006645 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 525897006646 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 525897006647 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 525897006648 Pilus assembly protein, PilP; Region: PilP; pfam04351 525897006649 Pilus assembly protein, PilO; Region: PilO; cl01234 525897006650 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 525897006651 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 525897006652 Cell division protein FtsA; Region: FtsA; pfam14450 525897006653 isocitrate dehydrogenase; Validated; Region: PRK06451 525897006654 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 525897006655 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 525897006656 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 525897006657 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 525897006658 active site 525897006659 catalytic residues [active] 525897006660 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 525897006661 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 525897006662 Response regulator receiver domain; Region: Response_reg; pfam00072 525897006663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006664 active site 525897006665 phosphorylation site [posttranslational modification] 525897006666 intermolecular recognition site; other site 525897006667 dimerization interface [polypeptide binding]; other site 525897006668 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 525897006669 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 525897006670 PAS fold; Region: PAS_4; pfam08448 525897006671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897006672 dimer interface [polypeptide binding]; other site 525897006673 phosphorylation site [posttranslational modification] 525897006674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897006675 ATP binding site [chemical binding]; other site 525897006676 Mg2+ binding site [ion binding]; other site 525897006677 G-X-G motif; other site 525897006678 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 525897006679 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 525897006680 HDOD domain; Region: HDOD; pfam08668 525897006681 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 525897006682 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 525897006683 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897006684 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897006685 putative active site [active] 525897006686 heme pocket [chemical binding]; other site 525897006687 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897006688 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897006689 putative active site [active] 525897006690 heme pocket [chemical binding]; other site 525897006691 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897006692 putative active site [active] 525897006693 heme pocket [chemical binding]; other site 525897006694 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 525897006695 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525897006696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897006697 binding surface 525897006698 TPR motif; other site 525897006699 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525897006700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897006701 binding surface 525897006702 TPR motif; other site 525897006703 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525897006704 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525897006705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897006706 TPR motif; other site 525897006707 binding surface 525897006708 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525897006709 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525897006710 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 525897006711 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 525897006712 ligand binding site [chemical binding]; other site 525897006713 helicase 45; Provisional; Region: PTZ00424 525897006714 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 525897006715 ATP binding site [chemical binding]; other site 525897006716 Mg++ binding site [ion binding]; other site 525897006717 motif III; other site 525897006718 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525897006719 nucleotide binding region [chemical binding]; other site 525897006720 ATP-binding site [chemical binding]; other site 525897006721 PAS domain; Region: PAS; smart00091 525897006722 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 525897006723 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897006724 putative active site [active] 525897006725 heme pocket [chemical binding]; other site 525897006726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897006727 Walker A motif; other site 525897006728 ATP binding site [chemical binding]; other site 525897006729 Walker B motif; other site 525897006730 arginine finger; other site 525897006731 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 525897006732 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 525897006733 inhibitor-cofactor binding pocket; inhibition site 525897006734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897006735 catalytic residue [active] 525897006736 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 525897006737 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 525897006738 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 525897006739 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 525897006740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897006741 Walker A/P-loop; other site 525897006742 ATP binding site [chemical binding]; other site 525897006743 Q-loop/lid; other site 525897006744 ABC transporter signature motif; other site 525897006745 Walker B; other site 525897006746 D-loop; other site 525897006747 H-loop/switch region; other site 525897006748 TOBE domain; Region: TOBE_2; pfam08402 525897006749 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 525897006750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897006751 dimer interface [polypeptide binding]; other site 525897006752 conserved gate region; other site 525897006753 putative PBP binding loops; other site 525897006754 ABC-ATPase subunit interface; other site 525897006755 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 525897006756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897006757 dimer interface [polypeptide binding]; other site 525897006758 conserved gate region; other site 525897006759 putative PBP binding loops; other site 525897006760 ABC-ATPase subunit interface; other site 525897006761 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 525897006762 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 525897006763 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 525897006764 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 525897006765 inhibitor-cofactor binding pocket; inhibition site 525897006766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897006767 catalytic residue [active] 525897006768 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 525897006769 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 525897006770 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 525897006771 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 525897006772 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 525897006773 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 525897006774 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 525897006775 ATP binding site [chemical binding]; other site 525897006776 Mg++ binding site [ion binding]; other site 525897006777 motif III; other site 525897006778 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525897006779 nucleotide binding region [chemical binding]; other site 525897006780 ATP-binding site [chemical binding]; other site 525897006781 aspartate aminotransferase; Provisional; Region: PRK05764 525897006782 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525897006783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897006784 homodimer interface [polypeptide binding]; other site 525897006785 catalytic residue [active] 525897006786 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525897006787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006788 active site 525897006789 phosphorylation site [posttranslational modification] 525897006790 intermolecular recognition site; other site 525897006791 dimerization interface [polypeptide binding]; other site 525897006792 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525897006793 DNA binding residues [nucleotide binding] 525897006794 dimerization interface [polypeptide binding]; other site 525897006795 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 525897006796 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 525897006797 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897006798 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 525897006799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006800 active site 525897006801 phosphorylation site [posttranslational modification] 525897006802 intermolecular recognition site; other site 525897006803 dimerization interface [polypeptide binding]; other site 525897006804 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897006805 Zn2+ binding site [ion binding]; other site 525897006806 Mg2+ binding site [ion binding]; other site 525897006807 Uncharacterized conserved protein [Function unknown]; Region: COG3422 525897006808 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 525897006809 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 525897006810 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 525897006811 G1 box; other site 525897006812 putative GEF interaction site [polypeptide binding]; other site 525897006813 GTP/Mg2+ binding site [chemical binding]; other site 525897006814 Switch I region; other site 525897006815 G2 box; other site 525897006816 G3 box; other site 525897006817 Switch II region; other site 525897006818 G4 box; other site 525897006819 G5 box; other site 525897006820 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 525897006821 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 525897006822 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 525897006823 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 525897006824 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 525897006825 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 525897006826 oligomer interface [polypeptide binding]; other site 525897006827 putative active site [active] 525897006828 metal binding site [ion binding]; metal-binding site 525897006829 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 525897006830 Rubredoxin; Region: Rubredoxin; pfam00301 525897006831 iron binding site [ion binding]; other site 525897006832 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 525897006833 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 525897006834 RNA binding site [nucleotide binding]; other site 525897006835 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 525897006836 RNA binding site [nucleotide binding]; other site 525897006837 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 525897006838 RNA binding site [nucleotide binding]; other site 525897006839 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 525897006840 RNA binding site [nucleotide binding]; other site 525897006841 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 525897006842 RNA binding site [nucleotide binding]; other site 525897006843 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 525897006844 active site 525897006845 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 525897006846 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 525897006847 Cupin domain; Region: Cupin_2; pfam07883 525897006848 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525897006849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525897006850 Exportin 1-like protein; Region: Xpo1; pfam08389 525897006851 PilZ domain; Region: PilZ; pfam07238 525897006852 putative peptidase; Provisional; Region: PRK11649 525897006853 Peptidase family M23; Region: Peptidase_M23; pfam01551 525897006854 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 525897006855 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 525897006856 active site 525897006857 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 525897006858 active site 2 [active] 525897006859 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897006860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006861 active site 525897006862 phosphorylation site [posttranslational modification] 525897006863 intermolecular recognition site; other site 525897006864 dimerization interface [polypeptide binding]; other site 525897006865 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897006866 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897006867 metal binding site [ion binding]; metal-binding site 525897006868 active site 525897006869 I-site; other site 525897006870 intracellular protease, PfpI family; Region: PfpI; TIGR01382 525897006871 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 525897006872 proposed catalytic triad [active] 525897006873 conserved cys residue [active] 525897006874 Response regulator receiver domain; Region: Response_reg; pfam00072 525897006875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006876 active site 525897006877 phosphorylation site [posttranslational modification] 525897006878 intermolecular recognition site; other site 525897006879 dimerization interface [polypeptide binding]; other site 525897006880 CBS domain; Region: CBS; pfam00571 525897006881 Response regulator receiver domain; Region: Response_reg; pfam00072 525897006882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006883 active site 525897006884 phosphorylation site [posttranslational modification] 525897006885 intermolecular recognition site; other site 525897006886 dimerization interface [polypeptide binding]; other site 525897006887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897006888 dimer interface [polypeptide binding]; other site 525897006889 phosphorylation site [posttranslational modification] 525897006890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897006891 ATP binding site [chemical binding]; other site 525897006892 Mg2+ binding site [ion binding]; other site 525897006893 G-X-G motif; other site 525897006894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006895 Response regulator receiver domain; Region: Response_reg; pfam00072 525897006896 active site 525897006897 phosphorylation site [posttranslational modification] 525897006898 intermolecular recognition site; other site 525897006899 dimerization interface [polypeptide binding]; other site 525897006900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897006901 dimer interface [polypeptide binding]; other site 525897006902 phosphorylation site [posttranslational modification] 525897006903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897006904 ATP binding site [chemical binding]; other site 525897006905 Mg2+ binding site [ion binding]; other site 525897006906 G-X-G motif; other site 525897006907 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897006908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897006909 Walker A motif; other site 525897006910 ATP binding site [chemical binding]; other site 525897006911 Walker B motif; other site 525897006912 arginine finger; other site 525897006913 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 525897006914 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 525897006915 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 525897006916 transmembrane helices; other site 525897006917 Response regulator receiver domain; Region: Response_reg; pfam00072 525897006918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897006919 active site 525897006920 phosphorylation site [posttranslational modification] 525897006921 intermolecular recognition site; other site 525897006922 dimerization interface [polypeptide binding]; other site 525897006923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897006924 ATP binding site [chemical binding]; other site 525897006925 Mg2+ binding site [ion binding]; other site 525897006926 G-X-G motif; other site 525897006927 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 525897006928 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 525897006929 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 525897006930 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 525897006931 diaminopimelate aminotransferase; Provisional; Region: PRK13983 525897006932 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 525897006933 metal binding site [ion binding]; metal-binding site 525897006934 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 525897006935 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 525897006936 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 525897006937 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 525897006938 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 525897006939 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 525897006940 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897006941 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 525897006942 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 525897006943 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 525897006944 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 525897006945 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 525897006946 multifunctional aminopeptidase A; Provisional; Region: PRK00913 525897006947 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 525897006948 interface (dimer of trimers) [polypeptide binding]; other site 525897006949 Substrate-binding/catalytic site; other site 525897006950 Zn-binding sites [ion binding]; other site 525897006951 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 525897006952 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 525897006953 putative NAD(P) binding site [chemical binding]; other site 525897006954 putative active site [active] 525897006955 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 525897006956 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 525897006957 Protein of unknown function (DUF523); Region: DUF523; pfam04463 525897006958 Uncharacterized conserved protein [Function unknown]; Region: COG3272 525897006959 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 525897006960 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525897006961 Ligand Binding Site [chemical binding]; other site 525897006962 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 525897006963 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 525897006964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 525897006965 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 525897006966 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 525897006967 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 525897006968 Uncharacterized conserved protein [Function unknown]; Region: COG0432 525897006969 malate synthase G; Provisional; Region: PRK02999 525897006970 active site 525897006971 LysE type translocator; Region: LysE; cl00565 525897006972 Catalytic domain of Protein Kinases; Region: PKc; cd00180 525897006973 active site 525897006974 ATP binding site [chemical binding]; other site 525897006975 substrate binding site [chemical binding]; other site 525897006976 activation loop (A-loop); other site 525897006977 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 525897006978 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 525897006979 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 525897006980 active site 525897006981 metal binding site [ion binding]; metal-binding site 525897006982 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 525897006983 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 525897006984 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 525897006985 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 525897006986 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 525897006987 Protein of unknown function DUF58; Region: DUF58; pfam01882 525897006988 MoxR-like ATPases [General function prediction only]; Region: COG0714 525897006989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897006990 Walker A motif; other site 525897006991 ATP binding site [chemical binding]; other site 525897006992 Walker B motif; other site 525897006993 arginine finger; other site 525897006994 dihydrodipicolinate reductase; Provisional; Region: PRK00048 525897006995 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 525897006996 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 525897006997 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 525897006998 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 525897006999 nucleotide binding pocket [chemical binding]; other site 525897007000 K-X-D-G motif; other site 525897007001 catalytic site [active] 525897007002 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 525897007003 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 525897007004 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 525897007005 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 525897007006 Dimer interface [polypeptide binding]; other site 525897007007 Ion channel; Region: Ion_trans_2; pfam07885 525897007008 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 525897007009 TrkA-N domain; Region: TrkA_N; pfam02254 525897007010 TrkA-C domain; Region: TrkA_C; pfam02080 525897007011 excinuclease ABC subunit B; Provisional; Region: PRK05298 525897007012 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525897007013 ATP binding site [chemical binding]; other site 525897007014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525897007015 nucleotide binding region [chemical binding]; other site 525897007016 ATP-binding site [chemical binding]; other site 525897007017 Ultra-violet resistance protein B; Region: UvrB; pfam12344 525897007018 UvrB/uvrC motif; Region: UVR; pfam02151 525897007019 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 525897007020 Ribophorin I; Region: Ribophorin_I; pfam04597 525897007021 hypothetical protein; Provisional; Region: PRK05255 525897007022 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 525897007023 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 525897007024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897007025 Walker A motif; other site 525897007026 ATP binding site [chemical binding]; other site 525897007027 Walker B motif; other site 525897007028 arginine finger; other site 525897007029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897007030 Walker A motif; other site 525897007031 ATP binding site [chemical binding]; other site 525897007032 Walker B motif; other site 525897007033 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 525897007034 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 525897007035 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 525897007036 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525897007037 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 525897007038 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 525897007039 active site residue [active] 525897007040 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 525897007041 conserved hypothetical protein; Region: TIGR02231 525897007042 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 525897007043 putative cation:proton antiport protein; Provisional; Region: PRK10669 525897007044 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 525897007045 TrkA-N domain; Region: TrkA_N; pfam02254 525897007046 TrkA-C domain; Region: TrkA_C; pfam02080 525897007047 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525897007048 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 525897007049 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897007050 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897007051 dimerization interface [polypeptide binding]; other site 525897007052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897007053 dimer interface [polypeptide binding]; other site 525897007054 phosphorylation site [posttranslational modification] 525897007055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897007056 ATP binding site [chemical binding]; other site 525897007057 Mg2+ binding site [ion binding]; other site 525897007058 G-X-G motif; other site 525897007059 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 525897007060 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525897007061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897007062 active site 525897007063 phosphorylation site [posttranslational modification] 525897007064 intermolecular recognition site; other site 525897007065 dimerization interface [polypeptide binding]; other site 525897007066 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525897007067 DNA binding site [nucleotide binding] 525897007068 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 525897007069 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 525897007070 Cytochrome c552; Region: Cytochrom_C552; pfam02335 525897007071 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 525897007072 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 525897007073 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 525897007074 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 525897007075 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 525897007076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007077 PAS domain; Region: PAS_9; pfam13426 525897007078 putative active site [active] 525897007079 heme pocket [chemical binding]; other site 525897007080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897007081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897007082 dimer interface [polypeptide binding]; other site 525897007083 phosphorylation site [posttranslational modification] 525897007084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897007085 ATP binding site [chemical binding]; other site 525897007086 Mg2+ binding site [ion binding]; other site 525897007087 G-X-G motif; other site 525897007088 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897007089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897007090 active site 525897007091 phosphorylation site [posttranslational modification] 525897007092 intermolecular recognition site; other site 525897007093 dimerization interface [polypeptide binding]; other site 525897007094 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 525897007095 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 525897007096 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 525897007097 B12 binding site [chemical binding]; other site 525897007098 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525897007099 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 525897007100 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 525897007101 Walker A/P-loop; other site 525897007102 ATP binding site [chemical binding]; other site 525897007103 Q-loop/lid; other site 525897007104 ABC transporter signature motif; other site 525897007105 Walker B; other site 525897007106 D-loop; other site 525897007107 H-loop/switch region; other site 525897007108 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 525897007109 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525897007110 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 525897007111 TM-ABC transporter signature motif; other site 525897007112 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525897007113 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 525897007114 TM-ABC transporter signature motif; other site 525897007115 PAS fold; Region: PAS; pfam00989 525897007116 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007117 putative active site [active] 525897007118 heme pocket [chemical binding]; other site 525897007119 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897007120 metal binding site [ion binding]; metal-binding site 525897007121 active site 525897007122 I-site; other site 525897007123 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 525897007124 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897007125 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897007126 metal binding site [ion binding]; metal-binding site 525897007127 active site 525897007128 I-site; other site 525897007129 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 525897007130 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 525897007131 active site 525897007132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897007133 S-adenosylmethionine binding site [chemical binding]; other site 525897007134 Peptidase family U32; Region: Peptidase_U32; cl03113 525897007135 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 525897007136 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 525897007137 ligand binding site [chemical binding]; other site 525897007138 flexible hinge region; other site 525897007139 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 525897007140 putative switch regulator; other site 525897007141 non-specific DNA interactions [nucleotide binding]; other site 525897007142 DNA binding site [nucleotide binding] 525897007143 sequence specific DNA binding site [nucleotide binding]; other site 525897007144 putative cAMP binding site [chemical binding]; other site 525897007145 Methyltransferase domain; Region: Methyltransf_18; pfam12847 525897007146 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 525897007147 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 525897007148 dimer interface [polypeptide binding]; other site 525897007149 acyl-activating enzyme (AAE) consensus motif; other site 525897007150 putative active site [active] 525897007151 AMP binding site [chemical binding]; other site 525897007152 putative CoA binding site [chemical binding]; other site 525897007153 Isochorismatase family; Region: Isochorismatase; pfam00857 525897007154 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 525897007155 catalytic triad [active] 525897007156 conserved cis-peptide bond; other site 525897007157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 525897007158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 525897007159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 525897007160 dimerization interface [polypeptide binding]; other site 525897007161 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 525897007162 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 525897007163 putative NAD(P) binding site [chemical binding]; other site 525897007164 Peptidase family M48; Region: Peptidase_M48; cl12018 525897007165 conserved hypothetical protein; Region: TIGR02285 525897007166 4Fe-4S binding domain; Region: Fer4; pfam00037 525897007167 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897007168 4Fe-4S binding domain; Region: Fer4_6; pfam12837 525897007169 Domain of unknown function (DUF202); Region: DUF202; pfam02656 525897007170 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 525897007171 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 525897007172 active site 525897007173 ADP/pyrophosphate binding site [chemical binding]; other site 525897007174 dimerization interface [polypeptide binding]; other site 525897007175 allosteric effector site; other site 525897007176 fructose-1,6-bisphosphate binding site; other site 525897007177 PAS domain S-box; Region: sensory_box; TIGR00229 525897007178 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897007179 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897007180 metal binding site [ion binding]; metal-binding site 525897007181 active site 525897007182 I-site; other site 525897007183 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 525897007184 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 525897007185 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 525897007186 homodimer interface [polypeptide binding]; other site 525897007187 substrate-cofactor binding pocket; other site 525897007188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897007189 catalytic residue [active] 525897007190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897007191 S-adenosylmethionine binding site [chemical binding]; other site 525897007192 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 525897007193 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 525897007194 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 525897007195 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 525897007196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525897007197 motif II; other site 525897007198 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 525897007199 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 525897007200 active site 525897007201 catalytic site [active] 525897007202 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897007203 Zn2+ binding site [ion binding]; other site 525897007204 Mg2+ binding site [ion binding]; other site 525897007205 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525897007206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525897007207 non-specific DNA binding site [nucleotide binding]; other site 525897007208 salt bridge; other site 525897007209 sequence-specific DNA binding site [nucleotide binding]; other site 525897007210 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 525897007211 succinic semialdehyde dehydrogenase; Region: PLN02278 525897007212 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 525897007213 tetramerization interface [polypeptide binding]; other site 525897007214 NAD(P) binding site [chemical binding]; other site 525897007215 catalytic residues [active] 525897007216 PAS fold; Region: PAS_4; pfam08448 525897007217 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007218 putative active site [active] 525897007219 heme pocket [chemical binding]; other site 525897007220 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 525897007221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897007222 Walker A motif; other site 525897007223 ATP binding site [chemical binding]; other site 525897007224 Walker B motif; other site 525897007225 arginine finger; other site 525897007226 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897007227 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 525897007228 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 525897007229 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 525897007230 dimer interface [polypeptide binding]; other site 525897007231 active site 525897007232 glycine loop; other site 525897007233 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 525897007234 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 525897007235 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 525897007236 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 525897007237 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 525897007238 DctM-like transporters; Region: DctM; pfam06808 525897007239 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 525897007240 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 525897007241 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 525897007242 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 525897007243 ThiS family; Region: ThiS; pfam02597 525897007244 charged pocket; other site 525897007245 hydrophobic patch; other site 525897007246 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 525897007247 molybdopterin synthase sulfurylase MoeB; Region: moeB; TIGR02355 525897007248 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 525897007249 ATP binding site [chemical binding]; other site 525897007250 substrate interface [chemical binding]; other site 525897007251 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 525897007252 GAF domain; Region: GAF; pfam01590 525897007253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897007254 Walker A motif; other site 525897007255 ATP binding site [chemical binding]; other site 525897007256 Walker B motif; other site 525897007257 arginine finger; other site 525897007258 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897007259 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 525897007260 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 525897007261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 525897007262 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 525897007263 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 525897007264 pyruvate carboxylase; Reviewed; Region: PRK12999 525897007265 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 525897007266 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525897007267 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 525897007268 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 525897007269 active site 525897007270 catalytic residues [active] 525897007271 metal binding site [ion binding]; metal-binding site 525897007272 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 525897007273 carboxyltransferase (CT) interaction site; other site 525897007274 biotinylation site [posttranslational modification]; other site 525897007275 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 525897007276 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 525897007277 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 525897007278 active site 525897007279 dimerization interface [polypeptide binding]; other site 525897007280 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 525897007281 CheB methylesterase; Region: CheB_methylest; pfam01339 525897007282 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 525897007283 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 525897007284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897007285 S-adenosylmethionine binding site [chemical binding]; other site 525897007286 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 525897007287 PAS domain; Region: PAS_10; pfam13596 525897007288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007289 PAS domain; Region: PAS_9; pfam13426 525897007290 putative active site [active] 525897007291 heme pocket [chemical binding]; other site 525897007292 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 525897007293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897007294 Walker A motif; other site 525897007295 ATP binding site [chemical binding]; other site 525897007296 Walker B motif; other site 525897007297 arginine finger; other site 525897007298 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897007299 eRF1 domain 3; Region: eRF1_3; pfam03465 525897007300 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 525897007301 putative amphipathic alpha helix; other site 525897007302 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 525897007303 HEAT repeats; Region: HEAT_2; pfam13646 525897007304 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 525897007305 BON domain; Region: BON; pfam04972 525897007306 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 525897007307 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 525897007308 arginine deiminase; Provisional; Region: PRK01388 525897007309 ornithine carbamoyltransferase; Validated; Region: PRK02102 525897007310 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 525897007311 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 525897007312 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 525897007313 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 525897007314 putative substrate binding site [chemical binding]; other site 525897007315 nucleotide binding site [chemical binding]; other site 525897007316 nucleotide binding site [chemical binding]; other site 525897007317 homodimer interface [polypeptide binding]; other site 525897007318 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 525897007319 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525897007320 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897007321 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 525897007322 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 525897007323 Walker A/P-loop; other site 525897007324 ATP binding site [chemical binding]; other site 525897007325 Q-loop/lid; other site 525897007326 ABC transporter signature motif; other site 525897007327 Walker B; other site 525897007328 D-loop; other site 525897007329 H-loop/switch region; other site 525897007330 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 525897007331 Walker A/P-loop; other site 525897007332 ATP binding site [chemical binding]; other site 525897007333 Q-loop/lid; other site 525897007334 ABC transporter signature motif; other site 525897007335 Walker B; other site 525897007336 D-loop; other site 525897007337 H-loop/switch region; other site 525897007338 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 525897007339 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 525897007340 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 525897007341 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 525897007342 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 525897007343 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525897007344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897007345 Walker A motif; other site 525897007346 ATP binding site [chemical binding]; other site 525897007347 Walker B motif; other site 525897007348 arginine finger; other site 525897007349 BON domain; Region: BON; pfam04972 525897007350 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 525897007351 BON domain; Region: BON; pfam04972 525897007352 BON domain; Region: BON; pfam04972 525897007353 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007354 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897007355 putative active site [active] 525897007356 heme pocket [chemical binding]; other site 525897007357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007358 putative active site [active] 525897007359 heme pocket [chemical binding]; other site 525897007360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897007361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897007362 dimer interface [polypeptide binding]; other site 525897007363 phosphorylation site [posttranslational modification] 525897007364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897007365 ATP binding site [chemical binding]; other site 525897007366 Mg2+ binding site [ion binding]; other site 525897007367 G-X-G motif; other site 525897007368 Response regulator receiver domain; Region: Response_reg; pfam00072 525897007369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897007370 active site 525897007371 phosphorylation site [posttranslational modification] 525897007372 intermolecular recognition site; other site 525897007373 dimerization interface [polypeptide binding]; other site 525897007374 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525897007375 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 525897007376 Putative glucoamylase; Region: Glycoamylase; pfam10091 525897007377 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 525897007378 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 525897007379 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 525897007380 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 525897007381 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 525897007382 HTH-like domain; Region: HTH_21; pfam13276 525897007383 Integrase core domain; Region: rve; pfam00665 525897007384 Integrase core domain; Region: rve_3; pfam13683 525897007385 Transposase; Region: HTH_Tnp_1; pfam01527 525897007386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007387 PAS domain; Region: PAS_9; pfam13426 525897007388 putative active site [active] 525897007389 heme pocket [chemical binding]; other site 525897007390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897007391 dimer interface [polypeptide binding]; other site 525897007392 phosphorylation site [posttranslational modification] 525897007393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897007394 ATP binding site [chemical binding]; other site 525897007395 Mg2+ binding site [ion binding]; other site 525897007396 G-X-G motif; other site 525897007397 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 525897007398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897007399 active site 525897007400 phosphorylation site [posttranslational modification] 525897007401 intermolecular recognition site; other site 525897007402 dimerization interface [polypeptide binding]; other site 525897007403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897007404 Walker A motif; other site 525897007405 ATP binding site [chemical binding]; other site 525897007406 Walker B motif; other site 525897007407 arginine finger; other site 525897007408 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897007409 GAF domain; Region: GAF_2; pfam13185 525897007410 GAF domain; Region: GAF_3; pfam13492 525897007411 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897007412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897007413 ATP binding site [chemical binding]; other site 525897007414 Mg2+ binding site [ion binding]; other site 525897007415 G-X-G motif; other site 525897007416 TIGR03790 family protein; Region: TIGR03790 525897007417 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 525897007418 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 525897007419 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 525897007420 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 525897007421 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 525897007422 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 525897007423 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 525897007424 Asp-box motif; other site 525897007425 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 525897007426 putative active site [active] 525897007427 putative metal binding site [ion binding]; other site 525897007428 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 525897007429 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 525897007430 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525897007431 acyl-activating enzyme (AAE) consensus motif; other site 525897007432 active site 525897007433 AMP binding site [chemical binding]; other site 525897007434 CoA binding site [chemical binding]; other site 525897007435 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 525897007436 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525897007437 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 525897007438 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 525897007439 trimer interface [polypeptide binding]; other site 525897007440 active site 525897007441 substrate binding site [chemical binding]; other site 525897007442 CoA binding site [chemical binding]; other site 525897007443 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 525897007444 putative trimer interface [polypeptide binding]; other site 525897007445 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 525897007446 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 525897007447 putative trimer interface [polypeptide binding]; other site 525897007448 putative CoA binding site [chemical binding]; other site 525897007449 putative CoA binding site [chemical binding]; other site 525897007450 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 525897007451 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897007452 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 525897007453 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897007454 putative homodimer interface [polypeptide binding]; other site 525897007455 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 525897007456 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 525897007457 O-Antigen ligase; Region: Wzy_C; pfam04932 525897007458 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 525897007459 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 525897007460 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 525897007461 DXD motif; other site 525897007462 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 525897007463 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 525897007464 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525897007465 catalytic residue [active] 525897007466 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 525897007467 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 525897007468 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 525897007469 putative active site [active] 525897007470 putative catalytic site [active] 525897007471 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 525897007472 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 525897007473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897007474 Walker A motif; other site 525897007475 ATP binding site [chemical binding]; other site 525897007476 Walker B motif; other site 525897007477 arginine finger; other site 525897007478 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 525897007479 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525897007480 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 525897007481 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 525897007482 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 525897007483 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 525897007484 SLBB domain; Region: SLBB; pfam10531 525897007485 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 525897007486 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 525897007487 Bacterial sugar transferase; Region: Bac_transf; pfam02397 525897007488 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 525897007489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897007490 binding surface 525897007491 TPR motif; other site 525897007492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897007493 TPR motif; other site 525897007494 binding surface 525897007495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897007496 binding surface 525897007497 TPR motif; other site 525897007498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897007499 binding surface 525897007500 TPR motif; other site 525897007501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897007502 TPR motif; other site 525897007503 binding surface 525897007504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897007505 binding surface 525897007506 TPR motif; other site 525897007507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897007508 binding surface 525897007509 TPR motif; other site 525897007510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897007511 binding surface 525897007512 TPR motif; other site 525897007513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897007514 binding surface 525897007515 TPR motif; other site 525897007516 AMIN domain; Region: AMIN; pfam11741 525897007517 hypothetical protein; Provisional; Region: PRK14852 525897007518 hypothetical protein; Provisional; Region: PRK14852 525897007519 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 525897007520 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 525897007521 Protein export membrane protein; Region: SecD_SecF; cl14618 525897007522 hypothetical protein; Provisional; Region: PRK14851 525897007523 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 525897007524 ATP binding site [chemical binding]; other site 525897007525 substrate interface [chemical binding]; other site 525897007526 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 525897007527 FMN binding site [chemical binding]; other site 525897007528 dimer interface [polypeptide binding]; other site 525897007529 CAAX prenyl protease-related protein; Region: pepcterm_CAAX; TIGR03008 525897007530 PilZ domain; Region: PilZ; pfam07238 525897007531 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897007532 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897007533 metal binding site [ion binding]; metal-binding site 525897007534 active site 525897007535 I-site; other site 525897007536 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 525897007537 circadian clock protein KaiC; Reviewed; Region: PRK09302 525897007538 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 525897007539 Walker A motif; other site 525897007540 Walker A motif; other site 525897007541 ATP binding site [chemical binding]; other site 525897007542 Walker B motif; other site 525897007543 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 525897007544 Walker A motif; other site 525897007545 ATP binding site [chemical binding]; other site 525897007546 Walker B motif; other site 525897007547 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 525897007548 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 525897007549 4Fe-4S binding domain; Region: Fer4; cl02805 525897007550 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897007551 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 525897007552 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 525897007553 putative [4Fe-4S] binding site [ion binding]; other site 525897007554 putative molybdopterin cofactor binding site [chemical binding]; other site 525897007555 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 525897007556 molybdopterin cofactor binding site; other site 525897007557 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 525897007558 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525897007559 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525897007560 DNA binding residues [nucleotide binding] 525897007561 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 525897007562 cobalamin synthase; Reviewed; Region: cobS; PRK00235 525897007563 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 525897007564 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 525897007565 FMN binding site [chemical binding]; other site 525897007566 substrate binding site [chemical binding]; other site 525897007567 putative catalytic residue [active] 525897007568 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 525897007569 Uncharacterized conserved protein [Function unknown]; Region: COG3334 525897007570 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 525897007571 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 525897007572 dimerization interface 3.5A [polypeptide binding]; other site 525897007573 active site 525897007574 flagellin; Provisional; Region: PRK12807 525897007575 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 525897007576 phosphomannomutase CpsG; Provisional; Region: PRK15414 525897007577 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 525897007578 active site 525897007579 substrate binding site [chemical binding]; other site 525897007580 metal binding site [ion binding]; metal-binding site 525897007581 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 525897007582 FAD binding domain; Region: FAD_binding_4; pfam01565 525897007583 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525897007584 Cysteine-rich domain; Region: CCG; pfam02754 525897007585 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 525897007586 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 525897007587 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 525897007588 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 525897007589 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 525897007590 catalytic residues [active] 525897007591 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 525897007592 dimer interface [polypeptide binding]; other site 525897007593 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 525897007594 catalytic triad [active] 525897007595 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 525897007596 putative FMN binding site [chemical binding]; other site 525897007597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897007598 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 525897007599 Walker A motif; other site 525897007600 ATP binding site [chemical binding]; other site 525897007601 Walker B motif; other site 525897007602 arginine finger; other site 525897007603 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897007604 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525897007605 PAS domain S-box; Region: sensory_box; TIGR00229 525897007606 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007607 putative active site [active] 525897007608 heme pocket [chemical binding]; other site 525897007609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897007610 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525897007611 Walker A motif; other site 525897007612 ATP binding site [chemical binding]; other site 525897007613 Walker B motif; other site 525897007614 arginine finger; other site 525897007615 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897007616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897007617 dimer interface [polypeptide binding]; other site 525897007618 phosphorylation site [posttranslational modification] 525897007619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897007620 ATP binding site [chemical binding]; other site 525897007621 Mg2+ binding site [ion binding]; other site 525897007622 G-X-G motif; other site 525897007623 Response regulator receiver domain; Region: Response_reg; pfam00072 525897007624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897007625 active site 525897007626 phosphorylation site [posttranslational modification] 525897007627 intermolecular recognition site; other site 525897007628 dimerization interface [polypeptide binding]; other site 525897007629 Response regulator receiver domain; Region: Response_reg; pfam00072 525897007630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897007631 active site 525897007632 phosphorylation site [posttranslational modification] 525897007633 intermolecular recognition site; other site 525897007634 dimerization interface [polypeptide binding]; other site 525897007635 Response regulator receiver domain; Region: Response_reg; pfam00072 525897007636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897007637 active site 525897007638 phosphorylation site [posttranslational modification] 525897007639 intermolecular recognition site; other site 525897007640 dimerization interface [polypeptide binding]; other site 525897007641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897007642 dimer interface [polypeptide binding]; other site 525897007643 phosphorylation site [posttranslational modification] 525897007644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897007645 ATP binding site [chemical binding]; other site 525897007646 Mg2+ binding site [ion binding]; other site 525897007647 G-X-G motif; other site 525897007648 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897007649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897007650 active site 525897007651 phosphorylation site [posttranslational modification] 525897007652 intermolecular recognition site; other site 525897007653 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525897007654 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 525897007655 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 525897007656 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 525897007657 P loop nucleotide binding; other site 525897007658 switch II; other site 525897007659 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525897007660 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 525897007661 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 525897007662 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 525897007663 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 525897007664 DNA binding residues [nucleotide binding] 525897007665 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 525897007666 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 525897007667 FOG: CBS domain [General function prediction only]; Region: COG0517 525897007668 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 525897007669 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 525897007670 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 525897007671 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 525897007672 Walker A/P-loop; other site 525897007673 ATP binding site [chemical binding]; other site 525897007674 Q-loop/lid; other site 525897007675 ABC transporter signature motif; other site 525897007676 Walker B; other site 525897007677 D-loop; other site 525897007678 H-loop/switch region; other site 525897007679 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 525897007680 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 525897007681 acyl-activating enzyme (AAE) consensus motif; other site 525897007682 putative AMP binding site [chemical binding]; other site 525897007683 putative active site [active] 525897007684 putative CoA binding site [chemical binding]; other site 525897007685 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525897007686 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 525897007687 TM-ABC transporter signature motif; other site 525897007688 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 525897007689 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 525897007690 TM-ABC transporter signature motif; other site 525897007691 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 525897007692 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 525897007693 putative ligand binding site [chemical binding]; other site 525897007694 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 525897007695 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 525897007696 Walker A/P-loop; other site 525897007697 ATP binding site [chemical binding]; other site 525897007698 Q-loop/lid; other site 525897007699 ABC transporter signature motif; other site 525897007700 Walker B; other site 525897007701 D-loop; other site 525897007702 H-loop/switch region; other site 525897007703 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525897007704 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 525897007705 acyl-activating enzyme (AAE) consensus motif; other site 525897007706 active site 525897007707 AMP binding site [chemical binding]; other site 525897007708 CoA binding site [chemical binding]; other site 525897007709 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897007710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897007711 active site 525897007712 phosphorylation site [posttranslational modification] 525897007713 intermolecular recognition site; other site 525897007714 dimerization interface [polypeptide binding]; other site 525897007715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897007716 Walker A motif; other site 525897007717 ATP binding site [chemical binding]; other site 525897007718 Walker B motif; other site 525897007719 arginine finger; other site 525897007720 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897007721 PAS fold; Region: PAS_4; pfam08448 525897007722 PAS domain S-box; Region: sensory_box; TIGR00229 525897007723 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007724 putative active site [active] 525897007725 heme pocket [chemical binding]; other site 525897007726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897007727 ATP binding site [chemical binding]; other site 525897007728 Mg2+ binding site [ion binding]; other site 525897007729 G-X-G motif; other site 525897007730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 525897007731 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 525897007732 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 525897007733 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 525897007734 phosphate binding site [ion binding]; other site 525897007735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 525897007736 Histidine kinase; Region: HisKA_3; pfam07730 525897007737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897007738 ATP binding site [chemical binding]; other site 525897007739 Mg2+ binding site [ion binding]; other site 525897007740 G-X-G motif; other site 525897007741 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525897007742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897007743 active site 525897007744 phosphorylation site [posttranslational modification] 525897007745 intermolecular recognition site; other site 525897007746 dimerization interface [polypeptide binding]; other site 525897007747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525897007748 DNA binding residues [nucleotide binding] 525897007749 dimerization interface [polypeptide binding]; other site 525897007750 Domain of unknown function DUF21; Region: DUF21; pfam01595 525897007751 FOG: CBS domain [General function prediction only]; Region: COG0517 525897007752 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 525897007753 Transporter associated domain; Region: CorC_HlyC; smart01091 525897007754 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525897007755 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 525897007756 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 525897007757 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 525897007758 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 525897007759 Walker A motif; other site 525897007760 Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579 525897007761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007762 PAS domain; Region: PAS_9; pfam13426 525897007763 putative active site [active] 525897007764 heme pocket [chemical binding]; other site 525897007765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897007766 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525897007767 Walker A motif; other site 525897007768 ATP binding site [chemical binding]; other site 525897007769 Walker B motif; other site 525897007770 arginine finger; other site 525897007771 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897007772 S-adenosylmethionine synthetase; Validated; Region: PRK05250 525897007773 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 525897007774 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 525897007775 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 525897007776 Adenosylhomocysteinase; Provisional; Region: PTZ00075 525897007777 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 525897007778 homotetramer interface [polypeptide binding]; other site 525897007779 ligand binding site [chemical binding]; other site 525897007780 catalytic site [active] 525897007781 NAD binding site [chemical binding]; other site 525897007782 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525897007783 dimerization interface [polypeptide binding]; other site 525897007784 putative DNA binding site [nucleotide binding]; other site 525897007785 putative Zn2+ binding site [ion binding]; other site 525897007786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897007787 Protein of unknown function (DUF721); Region: DUF721; pfam05258 525897007788 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 525897007789 active site 525897007790 Fic family protein [Function unknown]; Region: COG3177 525897007791 Fic/DOC family; Region: Fic; pfam02661 525897007792 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525897007793 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525897007794 substrate binding pocket [chemical binding]; other site 525897007795 membrane-bound complex binding site; other site 525897007796 hinge residues; other site 525897007797 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525897007798 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525897007799 substrate binding pocket [chemical binding]; other site 525897007800 membrane-bound complex binding site; other site 525897007801 hinge residues; other site 525897007802 PAS domain S-box; Region: sensory_box; TIGR00229 525897007803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007804 putative active site [active] 525897007805 heme pocket [chemical binding]; other site 525897007806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897007807 dimer interface [polypeptide binding]; other site 525897007808 phosphorylation site [posttranslational modification] 525897007809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897007810 ATP binding site [chemical binding]; other site 525897007811 Mg2+ binding site [ion binding]; other site 525897007812 G-X-G motif; other site 525897007813 Response regulator receiver domain; Region: Response_reg; pfam00072 525897007814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897007815 active site 525897007816 phosphorylation site [posttranslational modification] 525897007817 intermolecular recognition site; other site 525897007818 dimerization interface [polypeptide binding]; other site 525897007819 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 525897007820 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 525897007821 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 525897007822 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 525897007823 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897007824 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 525897007825 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 525897007826 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 525897007827 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 525897007828 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 525897007829 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 525897007830 dimer interface [polypeptide binding]; other site 525897007831 PYR/PP interface [polypeptide binding]; other site 525897007832 TPP binding site [chemical binding]; other site 525897007833 substrate binding site [chemical binding]; other site 525897007834 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 525897007835 TPP-binding site; other site 525897007836 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 525897007837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897007838 Walker A motif; other site 525897007839 ATP binding site [chemical binding]; other site 525897007840 Walker B motif; other site 525897007841 arginine finger; other site 525897007842 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 525897007843 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 525897007844 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 525897007845 dimer interface [polypeptide binding]; other site 525897007846 active site 525897007847 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525897007848 catalytic residues [active] 525897007849 substrate binding site [chemical binding]; other site 525897007850 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 525897007851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525897007852 arginine decarboxylase; Provisional; Region: PRK05354 525897007853 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 525897007854 dimer interface [polypeptide binding]; other site 525897007855 active site 525897007856 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525897007857 catalytic residues [active] 525897007858 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 525897007859 Predicted membrane protein [Function unknown]; Region: COG1971 525897007860 Domain of unknown function DUF; Region: DUF204; pfam02659 525897007861 Domain of unknown function DUF; Region: DUF204; pfam02659 525897007862 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 525897007863 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 525897007864 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 525897007865 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525897007866 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525897007867 substrate binding pocket [chemical binding]; other site 525897007868 membrane-bound complex binding site; other site 525897007869 hinge residues; other site 525897007870 PAS fold; Region: PAS_3; pfam08447 525897007871 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007872 putative active site [active] 525897007873 heme pocket [chemical binding]; other site 525897007874 PAS fold; Region: PAS_4; pfam08448 525897007875 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007876 putative active site [active] 525897007877 heme pocket [chemical binding]; other site 525897007878 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897007879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007880 putative active site [active] 525897007881 heme pocket [chemical binding]; other site 525897007882 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897007883 dimer interface [polypeptide binding]; other site 525897007884 phosphorylation site [posttranslational modification] 525897007885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897007886 ATP binding site [chemical binding]; other site 525897007887 Mg2+ binding site [ion binding]; other site 525897007888 G-X-G motif; other site 525897007889 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 525897007890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897007891 active site 525897007892 phosphorylation site [posttranslational modification] 525897007893 intermolecular recognition site; other site 525897007894 dimerization interface [polypeptide binding]; other site 525897007895 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897007896 Zn2+ binding site [ion binding]; other site 525897007897 Mg2+ binding site [ion binding]; other site 525897007898 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897007899 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007900 putative active site [active] 525897007901 heme pocket [chemical binding]; other site 525897007902 GAF domain; Region: GAF_3; pfam13492 525897007903 GAF domain; Region: GAF_2; pfam13185 525897007904 PAS domain S-box; Region: sensory_box; TIGR00229 525897007905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007906 putative active site [active] 525897007907 heme pocket [chemical binding]; other site 525897007908 PAS domain S-box; Region: sensory_box; TIGR00229 525897007909 PAS domain; Region: PAS; smart00091 525897007910 putative active site [active] 525897007911 heme pocket [chemical binding]; other site 525897007912 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897007913 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897007914 metal binding site [ion binding]; metal-binding site 525897007915 active site 525897007916 I-site; other site 525897007917 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 525897007918 hypothetical protein; Provisional; Region: PRK04334 525897007919 Dicarboxylate transport; Region: DctA-YdbH; cl14674 525897007920 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 525897007921 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 525897007922 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 525897007923 EamA-like transporter family; Region: EamA; pfam00892 525897007924 EamA-like transporter family; Region: EamA; pfam00892 525897007925 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525897007926 active site residue [active] 525897007927 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525897007928 active site residue [active] 525897007929 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525897007930 active site residue [active] 525897007931 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525897007932 active site residue [active] 525897007933 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 525897007934 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 525897007935 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 525897007936 4Fe-4S binding domain; Region: Fer4_6; pfam12837 525897007937 thiosulfate reductase PhsA; Provisional; Region: PRK15488 525897007938 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 525897007939 putative [Fe4-S4] binding site [ion binding]; other site 525897007940 putative molybdopterin cofactor binding site [chemical binding]; other site 525897007941 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 525897007942 putative molybdopterin cofactor binding site; other site 525897007943 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 525897007944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897007945 PAS domain; Region: PAS_9; pfam13426 525897007946 putative active site [active] 525897007947 heme pocket [chemical binding]; other site 525897007948 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 525897007949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897007950 Walker A motif; other site 525897007951 ATP binding site [chemical binding]; other site 525897007952 Walker B motif; other site 525897007953 arginine finger; other site 525897007954 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897007955 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525897007956 Cysteine-rich domain; Region: CCG; pfam02754 525897007957 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525897007958 Ligand Binding Site [chemical binding]; other site 525897007959 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525897007960 Ligand Binding Site [chemical binding]; other site 525897007961 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 525897007962 Cysteine-rich domain; Region: CCG; pfam02754 525897007963 Cysteine-rich domain; Region: CCG; pfam02754 525897007964 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897007965 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 525897007966 4Fe-4S binding domain; Region: Fer4; pfam00037 525897007967 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 525897007968 4Fe-4S binding domain; Region: Fer4; pfam00037 525897007969 Response regulator receiver domain; Region: Response_reg; pfam00072 525897007970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897007971 active site 525897007972 phosphorylation site [posttranslational modification] 525897007973 intermolecular recognition site; other site 525897007974 dimerization interface [polypeptide binding]; other site 525897007975 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 525897007976 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897007977 4Fe-4S binding domain; Region: Fer4; pfam00037 525897007978 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 525897007979 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 525897007980 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897007981 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 525897007982 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 525897007983 Transposase; Region: HTH_Tnp_1; cl17663 525897007984 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897007985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897007986 active site 525897007987 phosphorylation site [posttranslational modification] 525897007988 intermolecular recognition site; other site 525897007989 dimerization interface [polypeptide binding]; other site 525897007990 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897007991 Walker A motif; other site 525897007992 ATP binding site [chemical binding]; other site 525897007993 Walker B motif; other site 525897007994 arginine finger; other site 525897007995 Predicted permease [General function prediction only]; Region: COG2985 525897007996 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 525897007997 TrkA-C domain; Region: TrkA_C; pfam02080 525897007998 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 525897007999 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 525897008000 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 525897008001 CoenzymeA binding site [chemical binding]; other site 525897008002 subunit interaction site [polypeptide binding]; other site 525897008003 PHB binding site; other site 525897008004 molybdate ABC transporter periplasmic substrate-binding protein; Provisional; Region: PRK04168 525897008005 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 525897008006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525897008007 putative substrate translocation pore; other site 525897008008 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 525897008009 butyrate kinase; Provisional; Region: PRK03011 525897008010 Hemerythrin; Region: Hemerythrin; cd12107 525897008011 Fe binding site [ion binding]; other site 525897008012 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 525897008013 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 525897008014 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897008015 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 525897008016 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 525897008017 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 525897008018 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 525897008019 4Fe-4S binding domain; Region: Fer4; pfam00037 525897008020 4Fe-4S binding domain; Region: Fer4; pfam00037 525897008021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897008022 FeS/SAM binding site; other site 525897008023 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 525897008024 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 525897008025 dimer interface [polypeptide binding]; other site 525897008026 active site 525897008027 glycine loop; other site 525897008028 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525897008029 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525897008030 substrate binding pocket [chemical binding]; other site 525897008031 membrane-bound complex binding site; other site 525897008032 hinge residues; other site 525897008033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897008034 dimer interface [polypeptide binding]; other site 525897008035 conserved gate region; other site 525897008036 putative PBP binding loops; other site 525897008037 ABC-ATPase subunit interface; other site 525897008038 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525897008039 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 525897008040 Walker A/P-loop; other site 525897008041 ATP binding site [chemical binding]; other site 525897008042 Q-loop/lid; other site 525897008043 ABC transporter signature motif; other site 525897008044 Walker B; other site 525897008045 D-loop; other site 525897008046 H-loop/switch region; other site 525897008047 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525897008048 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 525897008049 active site 525897008050 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 525897008051 ATP-NAD kinase; Region: NAD_kinase; pfam01513 525897008052 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 525897008053 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 525897008054 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525897008055 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 525897008056 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 525897008057 rRNA interaction site [nucleotide binding]; other site 525897008058 S8 interaction site; other site 525897008059 putative laminin-1 binding site; other site 525897008060 elongation factor Ts; Provisional; Region: tsf; PRK09377 525897008061 UBA/TS-N domain; Region: UBA; pfam00627 525897008062 Elongation factor TS; Region: EF_TS; pfam00889 525897008063 Elongation factor TS; Region: EF_TS; pfam00889 525897008064 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 525897008065 putative nucleotide binding site [chemical binding]; other site 525897008066 uridine monophosphate binding site [chemical binding]; other site 525897008067 homohexameric interface [polypeptide binding]; other site 525897008068 ribosome recycling factor; Reviewed; Region: frr; PRK00083 525897008069 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 525897008070 hinge region; other site 525897008071 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 525897008072 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 525897008073 catalytic residue [active] 525897008074 putative FPP diphosphate binding site; other site 525897008075 putative FPP binding hydrophobic cleft; other site 525897008076 dimer interface [polypeptide binding]; other site 525897008077 putative IPP diphosphate binding site; other site 525897008078 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 525897008079 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 525897008080 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 525897008081 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 525897008082 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 525897008083 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 525897008084 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 525897008085 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 525897008086 active site 525897008087 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 525897008088 protein binding site [polypeptide binding]; other site 525897008089 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 525897008090 putative substrate binding region [chemical binding]; other site 525897008091 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 525897008092 Glycoprotease family; Region: Peptidase_M22; pfam00814 525897008093 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 525897008094 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 525897008095 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 525897008096 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 525897008097 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 525897008098 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 525897008099 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 525897008100 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 525897008101 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 525897008102 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 525897008103 active site 525897008104 dimer interface [polypeptide binding]; other site 525897008105 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 525897008106 Ligand Binding Site [chemical binding]; other site 525897008107 Molecular Tunnel; other site 525897008108 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 525897008109 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG2881 525897008110 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 525897008111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897008112 FeS/SAM binding site; other site 525897008113 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 525897008114 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 525897008115 dimer interface [polypeptide binding]; other site 525897008116 active site 525897008117 Schiff base residues; other site 525897008118 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 525897008119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897008120 FeS/SAM binding site; other site 525897008121 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 525897008122 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 525897008123 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 525897008124 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 525897008125 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 525897008126 substrate binding site [chemical binding]; other site 525897008127 hexamer interface [polypeptide binding]; other site 525897008128 metal binding site [ion binding]; metal-binding site 525897008129 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 525897008130 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 525897008131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897008132 active site 525897008133 phosphorylation site [posttranslational modification] 525897008134 intermolecular recognition site; other site 525897008135 dimerization interface [polypeptide binding]; other site 525897008136 LytTr DNA-binding domain; Region: LytTR; smart00850 525897008137 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 525897008138 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 525897008139 Histidine kinase; Region: His_kinase; pfam06580 525897008140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897008141 ATP binding site [chemical binding]; other site 525897008142 Mg2+ binding site [ion binding]; other site 525897008143 G-X-G motif; other site 525897008144 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 525897008145 Carbon starvation protein CstA; Region: CstA; pfam02554 525897008146 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 525897008147 flagellar assembly protein FliW; Provisional; Region: PRK13285 525897008148 Global regulator protein family; Region: CsrA; pfam02599 525897008149 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 525897008150 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 525897008151 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 525897008152 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 525897008153 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 525897008154 FlgN protein; Region: FlgN; pfam05130 525897008155 Rod binding protein; Region: Rod-binding; cl01626 525897008156 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 525897008157 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 525897008158 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 525897008159 Flagellar L-ring protein; Region: FlgH; pfam02107 525897008160 SAF-like; Region: SAF_2; pfam13144 525897008161 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 525897008162 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 525897008163 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 525897008164 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 525897008165 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 525897008166 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 525897008167 ribosome maturation protein RimP; Reviewed; Region: PRK00092 525897008168 hypothetical protein; Provisional; Region: PRK14641 525897008169 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 525897008170 putative oligomer interface [polypeptide binding]; other site 525897008171 putative RNA binding site [nucleotide binding]; other site 525897008172 transcription termination factor NusA; Region: NusA; TIGR01953 525897008173 NusA N-terminal domain; Region: NusA_N; pfam08529 525897008174 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 525897008175 RNA binding site [nucleotide binding]; other site 525897008176 homodimer interface [polypeptide binding]; other site 525897008177 NusA-like KH domain; Region: KH_5; pfam13184 525897008178 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 525897008179 G-X-X-G motif; other site 525897008180 Protein of unknown function (DUF448); Region: DUF448; pfam04296 525897008181 putative RNA binding cleft [nucleotide binding]; other site 525897008182 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 525897008183 translation initiation factor IF-2; Region: IF-2; TIGR00487 525897008184 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 525897008185 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 525897008186 G1 box; other site 525897008187 putative GEF interaction site [polypeptide binding]; other site 525897008188 GTP/Mg2+ binding site [chemical binding]; other site 525897008189 Switch I region; other site 525897008190 G2 box; other site 525897008191 G3 box; other site 525897008192 Switch II region; other site 525897008193 G4 box; other site 525897008194 G5 box; other site 525897008195 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 525897008196 Translation-initiation factor 2; Region: IF-2; pfam11987 525897008197 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 525897008198 Protein of unknown function (DUF503); Region: DUF503; pfam04456 525897008199 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 525897008200 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 525897008201 DHH family; Region: DHH; pfam01368 525897008202 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 525897008203 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 525897008204 RNA binding site [nucleotide binding]; other site 525897008205 active site 525897008206 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 525897008207 16S/18S rRNA binding site [nucleotide binding]; other site 525897008208 S13e-L30e interaction site [polypeptide binding]; other site 525897008209 25S rRNA binding site [nucleotide binding]; other site 525897008210 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 525897008211 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 525897008212 RNase E interface [polypeptide binding]; other site 525897008213 trimer interface [polypeptide binding]; other site 525897008214 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 525897008215 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 525897008216 RNase E interface [polypeptide binding]; other site 525897008217 trimer interface [polypeptide binding]; other site 525897008218 active site 525897008219 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 525897008220 putative nucleic acid binding region [nucleotide binding]; other site 525897008221 G-X-X-G motif; other site 525897008222 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 525897008223 RNA binding site [nucleotide binding]; other site 525897008224 domain interface; other site 525897008225 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG3366 525897008226 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 525897008227 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 525897008228 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 525897008229 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 525897008230 active site 525897008231 catalytic residues [active] 525897008232 metal binding site [ion binding]; metal-binding site 525897008233 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 525897008234 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 525897008235 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 525897008236 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 525897008237 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 525897008238 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525897008239 DRTGG domain; Region: DRTGG; pfam07085 525897008240 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 525897008241 CoA binding domain; Region: CoA_binding_2; pfam13380 525897008242 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 525897008243 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 525897008244 ribonuclease III; Reviewed; Region: rnc; PRK00102 525897008245 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 525897008246 dimerization interface [polypeptide binding]; other site 525897008247 active site 525897008248 metal binding site [ion binding]; metal-binding site 525897008249 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 525897008250 dsRNA binding site [nucleotide binding]; other site 525897008251 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 525897008252 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 525897008253 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 525897008254 FlaG protein; Region: FlaG; pfam03646 525897008255 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 525897008256 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 525897008257 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 525897008258 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 525897008259 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 525897008260 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 525897008261 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 525897008262 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 525897008263 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 525897008264 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 525897008265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897008266 S-adenosylmethionine binding site [chemical binding]; other site 525897008267 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 525897008268 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 525897008269 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 525897008270 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 525897008271 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 525897008272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897008273 putative active site [active] 525897008274 heme pocket [chemical binding]; other site 525897008275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897008276 Mg2+ binding site [ion binding]; other site 525897008277 G-X-G motif; other site 525897008278 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 525897008279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897008280 active site 525897008281 phosphorylation site [posttranslational modification] 525897008282 intermolecular recognition site; other site 525897008283 dimerization interface [polypeptide binding]; other site 525897008284 Transcriptional regulator; Region: CitT; pfam12431 525897008285 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 525897008286 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 525897008287 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 525897008288 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 525897008289 DctM-like transporters; Region: DctM; pfam06808 525897008290 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 525897008291 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 525897008292 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 525897008293 substrate binding site [chemical binding]; other site 525897008294 AMMECR1; Region: AMMECR1; pfam01871 525897008295 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 525897008296 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 525897008297 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 525897008298 active site 525897008299 substrate binding site [chemical binding]; other site 525897008300 cosubstrate binding site; other site 525897008301 catalytic site [active] 525897008302 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 525897008303 active site 525897008304 SAM binding site [chemical binding]; other site 525897008305 homodimer interface [polypeptide binding]; other site 525897008306 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 525897008307 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 525897008308 active site 525897008309 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 525897008310 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 525897008311 HIGH motif; other site 525897008312 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 525897008313 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 525897008314 active site 525897008315 KMSKS motif; other site 525897008316 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 525897008317 tRNA binding surface [nucleotide binding]; other site 525897008318 anticodon binding site; other site 525897008319 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 525897008320 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 525897008321 conserved cys residue [active] 525897008322 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897008323 Zn2+ binding site [ion binding]; other site 525897008324 Mg2+ binding site [ion binding]; other site 525897008325 Cation transport protein; Region: TrkH; cl17365 525897008326 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 525897008327 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 525897008328 TrkA-N domain; Region: TrkA_N; pfam02254 525897008329 TrkA-C domain; Region: TrkA_C; pfam02080 525897008330 TrkA-N domain; Region: TrkA_N; pfam02254 525897008331 TrkA-C domain; Region: TrkA_C; pfam02080 525897008332 Staphylococcal nuclease homologues; Region: SNc; smart00318 525897008333 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 525897008334 Catalytic site; other site 525897008335 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 525897008336 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 525897008337 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 525897008338 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 525897008339 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 525897008340 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 525897008341 DNA binding residues [nucleotide binding] 525897008342 DNA primase; Validated; Region: dnaG; PRK05667 525897008343 CHC2 zinc finger; Region: zf-CHC2; pfam01807 525897008344 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 525897008345 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 525897008346 active site 525897008347 metal binding site [ion binding]; metal-binding site 525897008348 interdomain interaction site; other site 525897008349 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 525897008350 MutS domain III; Region: MutS_III; pfam05192 525897008351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897008352 Walker A/P-loop; other site 525897008353 ATP binding site [chemical binding]; other site 525897008354 Q-loop/lid; other site 525897008355 ABC transporter signature motif; other site 525897008356 Walker B; other site 525897008357 D-loop; other site 525897008358 H-loop/switch region; other site 525897008359 Smr domain; Region: Smr; pfam01713 525897008360 Yqey-like protein; Region: YqeY; pfam09424 525897008361 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 525897008362 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 525897008363 IHF dimer interface [polypeptide binding]; other site 525897008364 IHF - DNA interface [nucleotide binding]; other site 525897008365 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 525897008366 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 525897008367 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 525897008368 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 525897008369 Ferritin-like domain; Region: Ferritin; pfam00210 525897008370 ferroxidase diiron center [ion binding]; other site 525897008371 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 525897008372 dimer interface [polypeptide binding]; other site 525897008373 catalytic triad [active] 525897008374 peroxidatic and resolving cysteines [active] 525897008375 Uncharacterized conserved protein [Function unknown]; Region: COG3379 525897008376 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 525897008377 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 525897008378 Part of AAA domain; Region: AAA_19; pfam13245 525897008379 Family description; Region: UvrD_C_2; pfam13538 525897008380 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 525897008381 Sulfate transporter family; Region: Sulfate_transp; pfam00916 525897008382 Sulfate transporter family; Region: Sulfate_transp; pfam00916 525897008383 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 525897008384 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 525897008385 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525897008386 Ligand Binding Site [chemical binding]; other site 525897008387 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525897008388 Ligand Binding Site [chemical binding]; other site 525897008389 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 525897008390 homodimer interaction site [polypeptide binding]; other site 525897008391 cofactor binding site; other site 525897008392 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 525897008393 intersubunit interface [polypeptide binding]; other site 525897008394 active site 525897008395 Zn2+ binding site [ion binding]; other site 525897008396 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 525897008397 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 525897008398 ATP binding site [chemical binding]; other site 525897008399 Mg++ binding site [ion binding]; other site 525897008400 motif III; other site 525897008401 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525897008402 nucleotide binding region [chemical binding]; other site 525897008403 ATP-binding site [chemical binding]; other site 525897008404 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 525897008405 RNA binding site [nucleotide binding]; other site 525897008406 Rubrerythrin [Energy production and conversion]; Region: COG1592 525897008407 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 525897008408 binuclear metal center [ion binding]; other site 525897008409 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 525897008410 iron binding site [ion binding]; other site 525897008411 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 525897008412 Competence-damaged protein; Region: CinA; pfam02464 525897008413 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 525897008414 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 525897008415 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 525897008416 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 525897008417 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 525897008418 elongation factor P; Validated; Region: PRK00529 525897008419 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 525897008420 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 525897008421 RNA binding site [nucleotide binding]; other site 525897008422 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 525897008423 RNA binding site [nucleotide binding]; other site 525897008424 Dehydroquinase class II; Region: DHquinase_II; pfam01220 525897008425 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 525897008426 trimer interface [polypeptide binding]; other site 525897008427 active site 525897008428 dimer interface [polypeptide binding]; other site 525897008429 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 525897008430 G1 box; other site 525897008431 GTP/Mg2+ binding site [chemical binding]; other site 525897008432 Switch I region; other site 525897008433 G2 box; other site 525897008434 G3 box; other site 525897008435 Switch II region; other site 525897008436 G4 box; other site 525897008437 G5 box; other site 525897008438 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 525897008439 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 525897008440 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 525897008441 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 525897008442 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 525897008443 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 525897008444 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 525897008445 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 525897008446 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 525897008447 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 525897008448 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525897008449 active site 525897008450 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 525897008451 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 525897008452 catalytic residues [active] 525897008453 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 525897008454 putative active site pocket [active] 525897008455 4-fold oligomerization interface [polypeptide binding]; other site 525897008456 metal binding residues [ion binding]; metal-binding site 525897008457 3-fold/trimer interface [polypeptide binding]; other site 525897008458 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 525897008459 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 525897008460 GMP synthase; Reviewed; Region: guaA; PRK00074 525897008461 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 525897008462 AMP/PPi binding site [chemical binding]; other site 525897008463 candidate oxyanion hole; other site 525897008464 catalytic triad [active] 525897008465 potential glutamine specificity residues [chemical binding]; other site 525897008466 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 525897008467 ATP Binding subdomain [chemical binding]; other site 525897008468 Ligand Binding sites [chemical binding]; other site 525897008469 Dimerization subdomain; other site 525897008470 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 525897008471 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 525897008472 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 525897008473 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 525897008474 active site 525897008475 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 525897008476 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 525897008477 Walker A/P-loop; other site 525897008478 ATP binding site [chemical binding]; other site 525897008479 Q-loop/lid; other site 525897008480 ABC transporter signature motif; other site 525897008481 Walker B; other site 525897008482 D-loop; other site 525897008483 H-loop/switch region; other site 525897008484 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 525897008485 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 525897008486 Walker A/P-loop; other site 525897008487 ATP binding site [chemical binding]; other site 525897008488 Q-loop/lid; other site 525897008489 ABC transporter signature motif; other site 525897008490 Walker B; other site 525897008491 D-loop; other site 525897008492 H-loop/switch region; other site 525897008493 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 525897008494 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 525897008495 TM-ABC transporter signature motif; other site 525897008496 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525897008497 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 525897008498 TM-ABC transporter signature motif; other site 525897008499 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 525897008500 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 525897008501 dimerization interface [polypeptide binding]; other site 525897008502 ligand binding site [chemical binding]; other site 525897008503 TPR repeat; Region: TPR_11; pfam13414 525897008504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897008505 binding surface 525897008506 TPR motif; other site 525897008507 TPR repeat; Region: TPR_11; pfam13414 525897008508 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 525897008509 CcmB protein; Region: CcmB; cl17444 525897008510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897008511 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 525897008512 Walker A/P-loop; other site 525897008513 ATP binding site [chemical binding]; other site 525897008514 Q-loop/lid; other site 525897008515 ABC transporter signature motif; other site 525897008516 Walker B; other site 525897008517 D-loop; other site 525897008518 H-loop/switch region; other site 525897008519 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 525897008520 CcmE; Region: CcmE; cl00994 525897008521 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 525897008522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525897008523 active site 525897008524 motif I; other site 525897008525 motif II; other site 525897008526 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897008527 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 525897008528 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 525897008529 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 525897008530 putative active site [active] 525897008531 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 525897008532 metal binding site 2 [ion binding]; metal-binding site 525897008533 putative DNA binding helix; other site 525897008534 metal binding site 1 [ion binding]; metal-binding site 525897008535 dimer interface [polypeptide binding]; other site 525897008536 structural Zn2+ binding site [ion binding]; other site 525897008537 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 525897008538 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 525897008539 non-heme iron binding site [ion binding]; other site 525897008540 dimer interface [polypeptide binding]; other site 525897008541 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 525897008542 non-heme iron binding site [ion binding]; other site 525897008543 dimer interface [polypeptide binding]; other site 525897008544 Rubredoxin; Region: Rubredoxin; pfam00301 525897008545 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 525897008546 iron binding site [ion binding]; other site 525897008547 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 525897008548 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525897008549 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 525897008550 HEAT-like repeat; Region: HEAT_EZ; pfam13513 525897008551 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 525897008552 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 525897008553 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 525897008554 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 525897008555 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 525897008556 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 525897008557 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 525897008558 Protein of unknown function (DUF497); Region: DUF497; pfam04365 525897008559 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 525897008560 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 525897008561 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 525897008562 putative active site [active] 525897008563 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 525897008564 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 525897008565 putative active site [active] 525897008566 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 525897008567 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 525897008568 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 525897008569 Fic family protein [Function unknown]; Region: COG3177 525897008570 Fic/DOC family; Region: Fic; pfam02661 525897008571 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 525897008572 Predicted transcriptional regulator [Transcription]; Region: COG3905 525897008573 PemK-like protein; Region: PemK; cl00995 525897008574 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 525897008575 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 525897008576 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 525897008577 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 525897008578 metal-binding site 525897008579 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 525897008580 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 525897008581 putative metal binding site; other site 525897008582 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 525897008583 putative trimer interface [polypeptide binding]; other site 525897008584 putative active site [active] 525897008585 putative substrate binding site [chemical binding]; other site 525897008586 putative CoA binding site [chemical binding]; other site 525897008587 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897008588 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897008589 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 525897008590 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 525897008591 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897008592 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 525897008593 putative ADP-binding pocket [chemical binding]; other site 525897008594 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525897008595 active site 525897008596 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 525897008597 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 525897008598 GDP-Fucose binding site [chemical binding]; other site 525897008599 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 525897008600 putative ligand binding site [chemical binding]; other site 525897008601 putative catalytic site [active] 525897008602 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 525897008603 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 525897008604 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 525897008605 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 525897008606 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 525897008607 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 525897008608 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 525897008609 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 525897008610 substrate binding site; other site 525897008611 tetramer interface; other site 525897008612 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 525897008613 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 525897008614 Substrate binding site; other site 525897008615 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 525897008616 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 525897008617 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 525897008618 NADP binding site [chemical binding]; other site 525897008619 active site 525897008620 putative substrate binding site [chemical binding]; other site 525897008621 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 525897008622 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 525897008623 NADP-binding site; other site 525897008624 homotetramer interface [polypeptide binding]; other site 525897008625 substrate binding site [chemical binding]; other site 525897008626 homodimer interface [polypeptide binding]; other site 525897008627 active site 525897008628 Transposase IS200 like; Region: Y1_Tnp; cl00848 525897008629 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 525897008630 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 525897008631 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 525897008632 four helix bundle protein; Region: TIGR02436 525897008633 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525897008634 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525897008635 non-specific DNA binding site [nucleotide binding]; other site 525897008636 salt bridge; other site 525897008637 sequence-specific DNA binding site [nucleotide binding]; other site 525897008638 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 525897008639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525897008640 non-specific DNA binding site [nucleotide binding]; other site 525897008641 salt bridge; other site 525897008642 sequence-specific DNA binding site [nucleotide binding]; other site 525897008643 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 525897008644 HicB family; Region: HicB; pfam05534 525897008645 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 525897008646 Predicted transcriptional regulator [Transcription]; Region: COG3905 525897008647 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 525897008648 PilZ domain; Region: PilZ; pfam07238 525897008649 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 525897008650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897008651 TPR motif; other site 525897008652 binding surface 525897008653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897008654 binding surface 525897008655 TPR motif; other site 525897008656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897008657 binding surface 525897008658 TPR repeat; Region: TPR_11; pfam13414 525897008659 TPR motif; other site 525897008660 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897008661 binding surface 525897008662 TPR motif; other site 525897008663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897008664 TPR motif; other site 525897008665 binding surface 525897008666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897008667 TPR motif; other site 525897008668 binding surface 525897008669 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 525897008670 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 525897008671 Mg++ binding site [ion binding]; other site 525897008672 putative catalytic motif [active] 525897008673 substrate binding site [chemical binding]; other site 525897008674 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 525897008675 exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152 525897008676 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 525897008677 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 525897008678 C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD); Region: AP_MHD_Cterm; cl10970 525897008679 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 525897008680 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525897008681 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 525897008682 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 525897008683 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 525897008684 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 525897008685 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 525897008686 PilZ domain; Region: PilZ; pfam07238 525897008687 Response regulator receiver domain; Region: Response_reg; pfam00072 525897008688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897008689 active site 525897008690 phosphorylation site [posttranslational modification] 525897008691 intermolecular recognition site; other site 525897008692 dimerization interface [polypeptide binding]; other site 525897008693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897008694 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525897008695 Walker A motif; other site 525897008696 ATP binding site [chemical binding]; other site 525897008697 Walker B motif; other site 525897008698 arginine finger; other site 525897008699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 525897008700 Peptidase M15; Region: Peptidase_M15_3; cl01194 525897008701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 525897008702 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 525897008703 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 525897008704 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 525897008705 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 525897008706 ligand binding site [chemical binding]; other site 525897008707 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525897008708 Ligand Binding Site [chemical binding]; other site 525897008709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897008710 dimer interface [polypeptide binding]; other site 525897008711 conserved gate region; other site 525897008712 putative PBP binding loops; other site 525897008713 ABC-ATPase subunit interface; other site 525897008714 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525897008715 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525897008716 substrate binding pocket [chemical binding]; other site 525897008717 membrane-bound complex binding site; other site 525897008718 hinge residues; other site 525897008719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897008720 dimer interface [polypeptide binding]; other site 525897008721 conserved gate region; other site 525897008722 putative PBP binding loops; other site 525897008723 ABC-ATPase subunit interface; other site 525897008724 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 525897008725 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 525897008726 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 525897008727 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897008728 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897008729 metal binding site [ion binding]; metal-binding site 525897008730 active site 525897008731 I-site; other site 525897008732 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 525897008733 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 525897008734 B12 binding site [chemical binding]; other site 525897008735 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897008736 FeS/SAM binding site; other site 525897008737 cell division protein FtsZ; Validated; Region: PRK09330 525897008738 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 525897008739 nucleotide binding site [chemical binding]; other site 525897008740 SulA interaction site; other site 525897008741 cell division protein FtsA; Region: ftsA; TIGR01174 525897008742 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 525897008743 nucleotide binding site [chemical binding]; other site 525897008744 Cell division protein FtsA; Region: FtsA; pfam14450 525897008745 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 525897008746 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 525897008747 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 525897008748 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525897008749 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525897008750 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525897008751 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 525897008752 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 525897008753 active site 525897008754 homodimer interface [polypeptide binding]; other site 525897008755 cell division protein FtsW; Region: ftsW; TIGR02614 525897008756 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 525897008757 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525897008758 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 525897008759 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 525897008760 Mg++ binding site [ion binding]; other site 525897008761 putative catalytic motif [active] 525897008762 putative substrate binding site [chemical binding]; other site 525897008763 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 525897008764 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525897008765 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525897008766 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525897008767 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 525897008768 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525897008769 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525897008770 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525897008771 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 525897008772 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 525897008773 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 525897008774 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 525897008775 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 525897008776 MraW methylase family; Region: Methyltransf_5; cl17771 525897008777 cell division protein MraZ; Reviewed; Region: PRK00326 525897008778 MraZ protein; Region: MraZ; pfam02381 525897008779 MraZ protein; Region: MraZ; pfam02381 525897008780 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 525897008781 Helix-turn-helix domain; Region: HTH_17; pfam12728 525897008782 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 525897008783 hydrogenase 4 subunit B; Validated; Region: PRK06521 525897008784 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 525897008785 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 525897008786 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 525897008787 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 525897008788 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 525897008789 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 525897008790 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 525897008791 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 525897008792 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897008793 4Fe-4S binding domain; Region: Fer4; pfam00037 525897008794 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 525897008795 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 525897008796 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 525897008797 ring oligomerisation interface [polypeptide binding]; other site 525897008798 ATP/Mg binding site [chemical binding]; other site 525897008799 stacking interactions; other site 525897008800 hinge regions; other site 525897008801 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 525897008802 oligomerisation interface [polypeptide binding]; other site 525897008803 mobile loop; other site 525897008804 roof hairpin; other site 525897008805 seryl-tRNA synthetase; Provisional; Region: PRK05431 525897008806 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 525897008807 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 525897008808 dimer interface [polypeptide binding]; other site 525897008809 active site 525897008810 motif 1; other site 525897008811 motif 2; other site 525897008812 motif 3; other site 525897008813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897008814 dimerization interface [polypeptide binding]; other site 525897008815 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 525897008816 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897008817 putative active site [active] 525897008818 heme pocket [chemical binding]; other site 525897008819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897008820 dimer interface [polypeptide binding]; other site 525897008821 phosphorylation site [posttranslational modification] 525897008822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897008823 ATP binding site [chemical binding]; other site 525897008824 Mg2+ binding site [ion binding]; other site 525897008825 G-X-G motif; other site 525897008826 Response regulator receiver domain; Region: Response_reg; pfam00072 525897008827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897008828 active site 525897008829 phosphorylation site [posttranslational modification] 525897008830 intermolecular recognition site; other site 525897008831 dimerization interface [polypeptide binding]; other site 525897008832 CHASE4 domain; Region: CHASE4; pfam05228 525897008833 PAS domain; Region: PAS_9; pfam13426 525897008834 PAS domain S-box; Region: sensory_box; TIGR00229 525897008835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897008836 putative active site [active] 525897008837 heme pocket [chemical binding]; other site 525897008838 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897008839 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897008840 metal binding site [ion binding]; metal-binding site 525897008841 active site 525897008842 I-site; other site 525897008843 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 525897008844 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 525897008845 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 525897008846 Chromate transporter; Region: Chromate_transp; cl17781 525897008847 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 525897008848 Cytochrome c; Region: Cytochrom_C; pfam00034 525897008849 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 525897008850 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897008851 dimer interface [polypeptide binding]; other site 525897008852 phosphorylation site [posttranslational modification] 525897008853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897008854 ATP binding site [chemical binding]; other site 525897008855 Mg2+ binding site [ion binding]; other site 525897008856 G-X-G motif; other site 525897008857 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 525897008858 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 525897008859 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 525897008860 Walker A motif; other site 525897008861 ATP binding site [chemical binding]; other site 525897008862 Walker B motif; other site 525897008863 HDOD domain; Region: HDOD; pfam08668 525897008864 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897008865 Zn2+ binding site [ion binding]; other site 525897008866 Mg2+ binding site [ion binding]; other site 525897008867 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 525897008868 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 525897008869 Bacterial Ig-like domain; Region: Big_5; pfam13205 525897008870 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 525897008871 MG2 domain; Region: A2M_N; pfam01835 525897008872 Alpha-2-macroglobulin family; Region: A2M; pfam00207 525897008873 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 525897008874 surface patch; other site 525897008875 thioester region; other site 525897008876 specificity defining residues; other site 525897008877 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 525897008878 Transglycosylase; Region: Transgly; pfam00912 525897008879 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 525897008880 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 525897008881 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 525897008882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897008883 Walker A motif; other site 525897008884 ATP binding site [chemical binding]; other site 525897008885 Walker B motif; other site 525897008886 arginine finger; other site 525897008887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 525897008888 AAA domain; Region: AAA_33; pfam13671 525897008889 Response regulator receiver domain; Region: Response_reg; pfam00072 525897008890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897008891 active site 525897008892 phosphorylation site [posttranslational modification] 525897008893 intermolecular recognition site; other site 525897008894 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897008895 dimerization interface [polypeptide binding]; other site 525897008896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897008897 putative active site [active] 525897008898 heme pocket [chemical binding]; other site 525897008899 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897008900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897008901 ATP binding site [chemical binding]; other site 525897008902 Mg2+ binding site [ion binding]; other site 525897008903 G-X-G motif; other site 525897008904 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897008905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897008906 active site 525897008907 phosphorylation site [posttranslational modification] 525897008908 intermolecular recognition site; other site 525897008909 dimerization interface [polypeptide binding]; other site 525897008910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897008911 Walker A motif; other site 525897008912 ATP binding site [chemical binding]; other site 525897008913 Walker B motif; other site 525897008914 arginine finger; other site 525897008915 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 525897008916 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 525897008917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897008918 active site 525897008919 phosphorylation site [posttranslational modification] 525897008920 intermolecular recognition site; other site 525897008921 dimerization interface [polypeptide binding]; other site 525897008922 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897008923 Zn2+ binding site [ion binding]; other site 525897008924 Mg2+ binding site [ion binding]; other site 525897008925 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 525897008926 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897008927 dimerization interface [polypeptide binding]; other site 525897008928 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897008929 dimer interface [polypeptide binding]; other site 525897008930 putative CheW interface [polypeptide binding]; other site 525897008931 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 525897008932 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897008933 dimer interface [polypeptide binding]; other site 525897008934 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 525897008935 putative CheW interface [polypeptide binding]; other site 525897008936 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 525897008937 putative CheA interaction surface; other site 525897008938 STAS domain; Region: STAS_2; pfam13466 525897008939 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897008940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897008941 active site 525897008942 phosphorylation site [posttranslational modification] 525897008943 intermolecular recognition site; other site 525897008944 dimerization interface [polypeptide binding]; other site 525897008945 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 525897008946 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 525897008947 putative binding surface; other site 525897008948 active site 525897008949 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 525897008950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897008951 ATP binding site [chemical binding]; other site 525897008952 Mg2+ binding site [ion binding]; other site 525897008953 G-X-G motif; other site 525897008954 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 525897008955 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897008956 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897008957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897008958 putative active site [active] 525897008959 heme pocket [chemical binding]; other site 525897008960 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897008961 putative active site [active] 525897008962 heme pocket [chemical binding]; other site 525897008963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897008964 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897008965 putative active site [active] 525897008966 heme pocket [chemical binding]; other site 525897008967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 525897008968 dimer interface [polypeptide binding]; other site 525897008969 phosphorylation site [posttranslational modification] 525897008970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897008971 ATP binding site [chemical binding]; other site 525897008972 Mg2+ binding site [ion binding]; other site 525897008973 G-X-G motif; other site 525897008974 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897008975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897008976 active site 525897008977 phosphorylation site [posttranslational modification] 525897008978 intermolecular recognition site; other site 525897008979 dimerization interface [polypeptide binding]; other site 525897008980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897008981 Walker A motif; other site 525897008982 ATP binding site [chemical binding]; other site 525897008983 Walker B motif; other site 525897008984 arginine finger; other site 525897008985 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 525897008986 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897008987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897008988 dimer interface [polypeptide binding]; other site 525897008989 phosphorylation site [posttranslational modification] 525897008990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897008991 ATP binding site [chemical binding]; other site 525897008992 Mg2+ binding site [ion binding]; other site 525897008993 G-X-G motif; other site 525897008994 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 525897008995 VacJ like lipoprotein; Region: VacJ; cl01073 525897008996 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 525897008997 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 525897008998 PhoU domain; Region: PhoU; pfam01895 525897008999 PhoU domain; Region: PhoU; pfam01895 525897009000 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 525897009001 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 525897009002 Walker A/P-loop; other site 525897009003 ATP binding site [chemical binding]; other site 525897009004 Q-loop/lid; other site 525897009005 ABC transporter signature motif; other site 525897009006 Walker B; other site 525897009007 D-loop; other site 525897009008 H-loop/switch region; other site 525897009009 HAMP domain; Region: HAMP; pfam00672 525897009010 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 525897009011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897009012 dimer interface [polypeptide binding]; other site 525897009013 phosphorylation site [posttranslational modification] 525897009014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897009015 ATP binding site [chemical binding]; other site 525897009016 Mg2+ binding site [ion binding]; other site 525897009017 G-X-G motif; other site 525897009018 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525897009019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897009020 active site 525897009021 phosphorylation site [posttranslational modification] 525897009022 intermolecular recognition site; other site 525897009023 dimerization interface [polypeptide binding]; other site 525897009024 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525897009025 DNA binding site [nucleotide binding] 525897009026 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 525897009027 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 525897009028 FOG: CBS domain [General function prediction only]; Region: COG0517 525897009029 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897009030 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897009031 metal binding site [ion binding]; metal-binding site 525897009032 active site 525897009033 I-site; other site 525897009034 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 525897009035 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 525897009036 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897009037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897009038 active site 525897009039 phosphorylation site [posttranslational modification] 525897009040 intermolecular recognition site; other site 525897009041 dimerization interface [polypeptide binding]; other site 525897009042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897009043 Walker A motif; other site 525897009044 ATP binding site [chemical binding]; other site 525897009045 Walker B motif; other site 525897009046 arginine finger; other site 525897009047 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897009048 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897009049 HAMP domain; Region: HAMP; pfam00672 525897009050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897009051 dimer interface [polypeptide binding]; other site 525897009052 phosphorylation site [posttranslational modification] 525897009053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897009054 ATP binding site [chemical binding]; other site 525897009055 Mg2+ binding site [ion binding]; other site 525897009056 G-X-G motif; other site 525897009057 Response regulator receiver domain; Region: Response_reg; pfam00072 525897009058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897009059 active site 525897009060 phosphorylation site [posttranslational modification] 525897009061 intermolecular recognition site; other site 525897009062 dimerization interface [polypeptide binding]; other site 525897009063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897009064 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525897009065 Walker A motif; other site 525897009066 ATP binding site [chemical binding]; other site 525897009067 Walker B motif; other site 525897009068 arginine finger; other site 525897009069 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 525897009070 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 525897009071 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 525897009072 Sulfate transporter family; Region: Sulfate_transp; pfam00916 525897009073 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 525897009074 Sulfate transporter family; Region: Sulfate_transp; pfam00916 525897009075 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 525897009076 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525897009077 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 525897009078 Chromate transporter; Region: Chromate_transp; pfam02417 525897009079 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 525897009080 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 525897009081 active site residue [active] 525897009082 Major Facilitator Superfamily; Region: MFS_1; pfam07690 525897009083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525897009084 putative substrate translocation pore; other site 525897009085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525897009086 PBP superfamily domain; Region: PBP_like_2; cl17296 525897009087 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 525897009088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897009089 dimer interface [polypeptide binding]; other site 525897009090 conserved gate region; other site 525897009091 putative PBP binding loops; other site 525897009092 ABC-ATPase subunit interface; other site 525897009093 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 525897009094 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 525897009095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897009096 dimer interface [polypeptide binding]; other site 525897009097 conserved gate region; other site 525897009098 putative PBP binding loops; other site 525897009099 ABC-ATPase subunit interface; other site 525897009100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 525897009101 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 525897009102 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 525897009103 putative dimer interface [polypeptide binding]; other site 525897009104 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 525897009105 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 525897009106 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 525897009107 putative valine binding site [chemical binding]; other site 525897009108 dimer interface [polypeptide binding]; other site 525897009109 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 525897009110 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 525897009111 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 525897009112 NAD(P) binding site [chemical binding]; other site 525897009113 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 525897009114 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 525897009115 substrate-cofactor binding pocket; other site 525897009116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897009117 catalytic residue [active] 525897009118 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 525897009119 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 525897009120 putative DNA binding site [nucleotide binding]; other site 525897009121 putative Zn2+ binding site [ion binding]; other site 525897009122 AsnC family; Region: AsnC_trans_reg; pfam01037 525897009123 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 525897009124 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 525897009125 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 525897009126 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897009127 FeS/SAM binding site; other site 525897009128 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 525897009129 IHF - DNA interface [nucleotide binding]; other site 525897009130 IHF dimer interface [polypeptide binding]; other site 525897009131 amphi-Trp domain; Region: amphi-Trp; TIGR04354 525897009132 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 525897009133 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 525897009134 phosphate binding site [ion binding]; other site 525897009135 putative substrate binding pocket [chemical binding]; other site 525897009136 dimer interface [polypeptide binding]; other site 525897009137 HprK-related kinase B; Region: HprK_rel_B; TIGR04355 525897009138 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 525897009139 active site 525897009140 metal-binding site [ion binding] 525897009141 nucleotide-binding site [chemical binding]; other site 525897009142 ATP-grasp enzyme, GAK system; Region: grasp_GAK; TIGR04356 525897009143 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525897009144 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 525897009145 PhoU domain; Region: PhoU; pfam01895 525897009146 PhoU domain; Region: PhoU; pfam01895 525897009147 Ecdysteroid kinase; Region: EcKinase; cl17738 525897009148 Phosphotransferase enzyme family; Region: APH; pfam01636 525897009149 amphi-Trp domain; Region: amphi-Trp; TIGR04354 525897009150 amphi-Trp domain; Region: amphi-Trp; TIGR04354 525897009151 XXXCH domain; Region: XXXCH_domain; TIGR04358 525897009152 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 525897009153 PHP domain; Region: PHP; pfam02811 525897009154 active site 525897009155 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 525897009156 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897009157 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 525897009158 PIN domain; Region: PIN_Smg5-Smg6-like; cd09880 525897009159 putative active site [active] 525897009160 PhoH-like protein; Region: PhoH; pfam02562 525897009161 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 525897009162 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 525897009163 putative active site [active] 525897009164 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 525897009165 dimer interface [polypeptide binding]; other site 525897009166 PAS domain; Region: PAS; smart00091 525897009167 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897009168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897009169 dimer interface [polypeptide binding]; other site 525897009170 phosphorylation site [posttranslational modification] 525897009171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897009172 ATP binding site [chemical binding]; other site 525897009173 Mg2+ binding site [ion binding]; other site 525897009174 G-X-G motif; other site 525897009175 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897009176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897009177 active site 525897009178 phosphorylation site [posttranslational modification] 525897009179 intermolecular recognition site; other site 525897009180 dimerization interface [polypeptide binding]; other site 525897009181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897009182 Walker A motif; other site 525897009183 ATP binding site [chemical binding]; other site 525897009184 Walker B motif; other site 525897009185 arginine finger; other site 525897009186 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 525897009187 nudix motif; other site 525897009188 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897009189 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525897009190 Ligand Binding Site [chemical binding]; other site 525897009191 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 525897009192 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 525897009193 transmembrane helices; other site 525897009194 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525897009195 Ligand Binding Site [chemical binding]; other site 525897009196 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 525897009197 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 525897009198 transmembrane helices; other site 525897009199 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 525897009200 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 525897009201 inhibitor-cofactor binding pocket; inhibition site 525897009202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897009203 catalytic residue [active] 525897009204 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 525897009205 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 525897009206 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 525897009207 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 525897009208 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 525897009209 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 525897009210 dimer interface [polypeptide binding]; other site 525897009211 PYR/PP interface [polypeptide binding]; other site 525897009212 TPP binding site [chemical binding]; other site 525897009213 substrate binding site [chemical binding]; other site 525897009214 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 525897009215 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 525897009216 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 525897009217 TPP-binding site [chemical binding]; other site 525897009218 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 525897009219 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 525897009220 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 525897009221 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 525897009222 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 525897009223 shikimate binding site; other site 525897009224 NAD(P) binding site [chemical binding]; other site 525897009225 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 525897009226 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 525897009227 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 525897009228 putative active site [active] 525897009229 metal binding site [ion binding]; metal-binding site 525897009230 GAF domain; Region: GAF; pfam01590 525897009231 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 525897009232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897009233 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897009234 putative active site [active] 525897009235 heme pocket [chemical binding]; other site 525897009236 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897009237 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897009238 putative active site [active] 525897009239 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897009240 dimer interface [polypeptide binding]; other site 525897009241 phosphorylation site [posttranslational modification] 525897009242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897009243 ATP binding site [chemical binding]; other site 525897009244 Mg2+ binding site [ion binding]; other site 525897009245 G-X-G motif; other site 525897009246 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 525897009247 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 525897009248 N-acetyl-D-glucosamine binding site [chemical binding]; other site 525897009249 catalytic residue [active] 525897009250 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 525897009251 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 525897009252 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 525897009253 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 525897009254 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 525897009255 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 525897009256 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 525897009257 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 525897009258 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 525897009259 flagellar motor switch protein; Validated; Region: fliN; PRK05698 525897009260 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 525897009261 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 525897009262 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 525897009263 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 525897009264 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 525897009265 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 525897009266 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 525897009267 ligand binding site [chemical binding]; other site 525897009268 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 525897009269 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 525897009270 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 525897009271 ligand binding site [chemical binding]; other site 525897009272 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 525897009273 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 525897009274 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 525897009275 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525897009276 catalytic residue [active] 525897009277 GTPase Era; Reviewed; Region: era; PRK00089 525897009278 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 525897009279 G1 box; other site 525897009280 GTP/Mg2+ binding site [chemical binding]; other site 525897009281 Switch I region; other site 525897009282 G2 box; other site 525897009283 Switch II region; other site 525897009284 G3 box; other site 525897009285 G4 box; other site 525897009286 G5 box; other site 525897009287 KH domain; Region: KH_2; pfam07650 525897009288 G-X-X-G motif; other site 525897009289 DNA topoisomerase I; Validated; Region: PRK06599 525897009290 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 525897009291 active site 525897009292 interdomain interaction site; other site 525897009293 putative metal-binding site [ion binding]; other site 525897009294 nucleotide binding site [chemical binding]; other site 525897009295 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 525897009296 domain I; other site 525897009297 DNA binding groove [nucleotide binding] 525897009298 phosphate binding site [ion binding]; other site 525897009299 domain II; other site 525897009300 domain III; other site 525897009301 nucleotide binding site [chemical binding]; other site 525897009302 catalytic site [active] 525897009303 domain IV; other site 525897009304 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 525897009305 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 525897009306 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 525897009307 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 525897009308 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 525897009309 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 525897009310 DHH family; Region: DHH; pfam01368 525897009311 DHHA1 domain; Region: DHHA1; pfam02272 525897009312 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 525897009313 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 525897009314 catalytic loop [active] 525897009315 iron binding site [ion binding]; other site 525897009316 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 525897009317 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 525897009318 dimerization interface [polypeptide binding]; other site 525897009319 putative ATP binding site [chemical binding]; other site 525897009320 Transcriptional regulator [Transcription]; Region: LysR; COG0583 525897009321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 525897009322 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 525897009323 putative dimerization interface [polypeptide binding]; other site 525897009324 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 525897009325 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 525897009326 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 525897009327 alphaNTD - beta interaction site [polypeptide binding]; other site 525897009328 alphaNTD homodimer interface [polypeptide binding]; other site 525897009329 alphaNTD - beta' interaction site [polypeptide binding]; other site 525897009330 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 525897009331 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 525897009332 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 525897009333 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525897009334 RNA binding surface [nucleotide binding]; other site 525897009335 30S ribosomal protein S11; Validated; Region: PRK05309 525897009336 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 525897009337 30S ribosomal protein S13; Region: bact_S13; TIGR03631 525897009338 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 525897009339 active site 525897009340 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 525897009341 SecY translocase; Region: SecY; pfam00344 525897009342 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 525897009343 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 525897009344 23S rRNA binding site [nucleotide binding]; other site 525897009345 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 525897009346 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 525897009347 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 525897009348 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 525897009349 5S rRNA interface [nucleotide binding]; other site 525897009350 23S rRNA interface [nucleotide binding]; other site 525897009351 L5 interface [polypeptide binding]; other site 525897009352 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 525897009353 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 525897009354 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 525897009355 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 525897009356 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 525897009357 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 525897009358 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 525897009359 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 525897009360 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 525897009361 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 525897009362 RNA binding site [nucleotide binding]; other site 525897009363 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 525897009364 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 525897009365 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 525897009366 23S rRNA interface [nucleotide binding]; other site 525897009367 putative translocon interaction site; other site 525897009368 signal recognition particle (SRP54) interaction site; other site 525897009369 L23 interface [polypeptide binding]; other site 525897009370 trigger factor interaction site; other site 525897009371 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 525897009372 23S rRNA interface [nucleotide binding]; other site 525897009373 5S rRNA interface [nucleotide binding]; other site 525897009374 putative antibiotic binding site [chemical binding]; other site 525897009375 L25 interface [polypeptide binding]; other site 525897009376 L27 interface [polypeptide binding]; other site 525897009377 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 525897009378 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 525897009379 G-X-X-G motif; other site 525897009380 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 525897009381 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 525897009382 putative translocon binding site; other site 525897009383 protein-rRNA interface [nucleotide binding]; other site 525897009384 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 525897009385 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 525897009386 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 525897009387 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 525897009388 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 525897009389 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 525897009390 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 525897009391 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 525897009392 elongation factor Tu; Reviewed; Region: PRK00049 525897009393 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 525897009394 G1 box; other site 525897009395 GEF interaction site [polypeptide binding]; other site 525897009396 GTP/Mg2+ binding site [chemical binding]; other site 525897009397 Switch I region; other site 525897009398 G2 box; other site 525897009399 G3 box; other site 525897009400 Switch II region; other site 525897009401 G4 box; other site 525897009402 G5 box; other site 525897009403 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 525897009404 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 525897009405 Antibiotic Binding Site [chemical binding]; other site 525897009406 elongation factor G; Reviewed; Region: PRK00007 525897009407 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 525897009408 G1 box; other site 525897009409 putative GEF interaction site [polypeptide binding]; other site 525897009410 GTP/Mg2+ binding site [chemical binding]; other site 525897009411 Switch I region; other site 525897009412 G2 box; other site 525897009413 G3 box; other site 525897009414 Switch II region; other site 525897009415 G4 box; other site 525897009416 G5 box; other site 525897009417 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 525897009418 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 525897009419 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 525897009420 30S ribosomal protein S7; Validated; Region: PRK05302 525897009421 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 525897009422 S17 interaction site [polypeptide binding]; other site 525897009423 S8 interaction site; other site 525897009424 16S rRNA interaction site [nucleotide binding]; other site 525897009425 streptomycin interaction site [chemical binding]; other site 525897009426 23S rRNA interaction site [nucleotide binding]; other site 525897009427 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 525897009428 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 525897009429 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 525897009430 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 525897009431 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 525897009432 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 525897009433 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 525897009434 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 525897009435 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 525897009436 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 525897009437 DNA binding site [nucleotide binding] 525897009438 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 525897009439 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 525897009440 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 525897009441 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 525897009442 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 525897009443 RPB11 interaction site [polypeptide binding]; other site 525897009444 RPB12 interaction site [polypeptide binding]; other site 525897009445 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 525897009446 RPB3 interaction site [polypeptide binding]; other site 525897009447 RPB1 interaction site [polypeptide binding]; other site 525897009448 RPB11 interaction site [polypeptide binding]; other site 525897009449 RPB10 interaction site [polypeptide binding]; other site 525897009450 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 525897009451 core dimer interface [polypeptide binding]; other site 525897009452 peripheral dimer interface [polypeptide binding]; other site 525897009453 L10 interface [polypeptide binding]; other site 525897009454 L11 interface [polypeptide binding]; other site 525897009455 putative EF-Tu interaction site [polypeptide binding]; other site 525897009456 putative EF-G interaction site [polypeptide binding]; other site 525897009457 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 525897009458 23S rRNA interface [nucleotide binding]; other site 525897009459 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 525897009460 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 525897009461 mRNA/rRNA interface [nucleotide binding]; other site 525897009462 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 525897009463 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 525897009464 23S rRNA interface [nucleotide binding]; other site 525897009465 L7/L12 interface [polypeptide binding]; other site 525897009466 putative thiostrepton binding site; other site 525897009467 L25 interface [polypeptide binding]; other site 525897009468 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 525897009469 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 525897009470 putative homodimer interface [polypeptide binding]; other site 525897009471 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 525897009472 heterodimer interface [polypeptide binding]; other site 525897009473 homodimer interface [polypeptide binding]; other site 525897009474 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 525897009475 elongation factor Tu; Reviewed; Region: PRK00049 525897009476 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 525897009477 G1 box; other site 525897009478 GEF interaction site [polypeptide binding]; other site 525897009479 GTP/Mg2+ binding site [chemical binding]; other site 525897009480 Switch I region; other site 525897009481 G2 box; other site 525897009482 G3 box; other site 525897009483 Switch II region; other site 525897009484 G4 box; other site 525897009485 G5 box; other site 525897009486 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 525897009487 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 525897009488 Antibiotic Binding Site [chemical binding]; other site 525897009489 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 525897009490 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 525897009491 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 525897009492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897009493 S-adenosylmethionine binding site [chemical binding]; other site 525897009494 peptide chain release factor 1; Validated; Region: prfA; PRK00591 525897009495 This domain is found in peptide chain release factors; Region: PCRF; smart00937 525897009496 RF-1 domain; Region: RF-1; pfam00472 525897009497 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 525897009498 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 525897009499 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 525897009500 CoA binding domain; Region: CoA_binding; pfam02629 525897009501 ATP synthase subunit C; Region: ATP-synt_C; cl00466 525897009502 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 525897009503 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 525897009504 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 525897009505 AAA domain; Region: AAA_32; pfam13654 525897009506 ATP-dependent protease Lon; Provisional; Region: PRK13765 525897009507 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 525897009508 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 525897009509 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897009510 Zn2+ binding site [ion binding]; other site 525897009511 Mg2+ binding site [ion binding]; other site 525897009512 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 525897009513 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 525897009514 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 525897009515 putative active site; other site 525897009516 catalytic residue [active] 525897009517 Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465 525897009518 3-dehydroquinate synthase; Provisional; Region: PRK02290 525897009519 Chorismate mutase type II; Region: CM_2; pfam01817 525897009520 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 525897009521 Prephenate dehydratase; Region: PDT; pfam00800 525897009522 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 525897009523 putative L-Phe binding site [chemical binding]; other site 525897009524 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 525897009525 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 525897009526 hinge; other site 525897009527 active site 525897009528 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 525897009529 arogenate dehydrogenase; Region: PLN02256 525897009530 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 525897009531 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 525897009532 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 525897009533 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 525897009534 Glutamine amidotransferase class-I; Region: GATase; pfam00117 525897009535 glutamine binding [chemical binding]; other site 525897009536 catalytic triad [active] 525897009537 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 525897009538 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 525897009539 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 525897009540 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 525897009541 active site 525897009542 ribulose/triose binding site [chemical binding]; other site 525897009543 phosphate binding site [ion binding]; other site 525897009544 substrate (anthranilate) binding pocket [chemical binding]; other site 525897009545 product (indole) binding pocket [chemical binding]; other site 525897009546 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 525897009547 active site 525897009548 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 525897009549 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 525897009550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897009551 catalytic residue [active] 525897009552 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 525897009553 substrate binding site [chemical binding]; other site 525897009554 active site 525897009555 catalytic residues [active] 525897009556 heterodimer interface [polypeptide binding]; other site 525897009557 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 525897009558 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 525897009559 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 525897009560 Transcriptional regulators [Transcription]; Region: FadR; COG2186 525897009561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525897009562 DNA-binding site [nucleotide binding]; DNA binding site 525897009563 FCD domain; Region: FCD; pfam07729 525897009564 choline dehydrogenase; Validated; Region: PRK02106 525897009565 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 525897009566 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 525897009567 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 525897009568 tetramerization interface [polypeptide binding]; other site 525897009569 NAD(P) binding site [chemical binding]; other site 525897009570 catalytic residues [active] 525897009571 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 525897009572 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 525897009573 zinc transporter ZupT; Provisional; Region: PRK04201 525897009574 ZIP Zinc transporter; Region: Zip; pfam02535 525897009575 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 525897009576 Domain of unknown function DUF21; Region: DUF21; pfam01595 525897009577 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 525897009578 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525897009579 dimerization interface [polypeptide binding]; other site 525897009580 putative DNA binding site [nucleotide binding]; other site 525897009581 putative Zn2+ binding site [ion binding]; other site 525897009582 Response regulator receiver domain; Region: Response_reg; pfam00072 525897009583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897009584 active site 525897009585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897009586 phosphorylation site [posttranslational modification] 525897009587 intermolecular recognition site; other site 525897009588 dimerization interface [polypeptide binding]; other site 525897009589 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 525897009590 dimer interface [polypeptide binding]; other site 525897009591 phosphorylation site [posttranslational modification] 525897009592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897009593 ATP binding site [chemical binding]; other site 525897009594 Mg2+ binding site [ion binding]; other site 525897009595 G-X-G motif; other site 525897009596 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525897009597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897009598 active site 525897009599 phosphorylation site [posttranslational modification] 525897009600 intermolecular recognition site; other site 525897009601 dimerization interface [polypeptide binding]; other site 525897009602 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897009603 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897009604 putative active site [active] 525897009605 heme pocket [chemical binding]; other site 525897009606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897009607 dimer interface [polypeptide binding]; other site 525897009608 phosphorylation site [posttranslational modification] 525897009609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897009610 ATP binding site [chemical binding]; other site 525897009611 Mg2+ binding site [ion binding]; other site 525897009612 G-X-G motif; other site 525897009613 Protein of unknown function (DUF554); Region: DUF554; pfam04474 525897009614 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 525897009615 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 525897009616 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 525897009617 active site 525897009618 metal binding site [ion binding]; metal-binding site 525897009619 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 525897009620 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 525897009621 glutaminase active site [active] 525897009622 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 525897009623 dimer interface [polypeptide binding]; other site 525897009624 active site 525897009625 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 525897009626 dimer interface [polypeptide binding]; other site 525897009627 active site 525897009628 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 525897009629 active site 525897009630 dimerization interface [polypeptide binding]; other site 525897009631 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 525897009632 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 525897009633 ATP binding site [chemical binding]; other site 525897009634 Ubiquitin-like proteins; Region: UBQ; cl00155 525897009635 charged pocket; other site 525897009636 hydrophobic patch; other site 525897009637 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 525897009638 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525897009639 Putative Fe-S cluster; Region: FeS; cl17515 525897009640 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 525897009641 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 525897009642 dimer interface [polypeptide binding]; other site 525897009643 motif 1; other site 525897009644 active site 525897009645 motif 2; other site 525897009646 motif 3; other site 525897009647 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 525897009648 anticodon binding site; other site 525897009649 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 525897009650 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 525897009651 dimer interface [polypeptide binding]; other site 525897009652 anticodon binding site; other site 525897009653 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 525897009654 homodimer interface [polypeptide binding]; other site 525897009655 motif 1; other site 525897009656 active site 525897009657 motif 2; other site 525897009658 GAD domain; Region: GAD; pfam02938 525897009659 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 525897009660 motif 3; other site 525897009661 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 525897009662 active site 525897009663 catalytic residues [active] 525897009664 metal binding site [ion binding]; metal-binding site 525897009665 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 525897009666 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 525897009667 putative active site [active] 525897009668 substrate binding site [chemical binding]; other site 525897009669 putative cosubstrate binding site; other site 525897009670 catalytic site [active] 525897009671 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 525897009672 substrate binding site [chemical binding]; other site 525897009673 Protein of unknown function DUF116; Region: DUF116; pfam01976 525897009674 16S rRNA methyltransferase B; Provisional; Region: PRK14904 525897009675 NusB family; Region: NusB; pfam01029 525897009676 putative RNA binding site [nucleotide binding]; other site 525897009677 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 525897009678 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 525897009679 PhnA protein; Region: PhnA; pfam03831 525897009680 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 525897009681 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 525897009682 heterodimer interface [polypeptide binding]; other site 525897009683 active site 525897009684 FMN binding site [chemical binding]; other site 525897009685 homodimer interface [polypeptide binding]; other site 525897009686 substrate binding site [chemical binding]; other site 525897009687 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 525897009688 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 525897009689 FAD binding pocket [chemical binding]; other site 525897009690 FAD binding motif [chemical binding]; other site 525897009691 phosphate binding motif [ion binding]; other site 525897009692 beta-alpha-beta structure motif; other site 525897009693 NAD binding pocket [chemical binding]; other site 525897009694 Iron coordination center [ion binding]; other site 525897009695 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 525897009696 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 525897009697 Walker A/P-loop; other site 525897009698 ATP binding site [chemical binding]; other site 525897009699 Q-loop/lid; other site 525897009700 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 525897009701 Q-loop/lid; other site 525897009702 ABC transporter signature motif; other site 525897009703 Walker B; other site 525897009704 D-loop; other site 525897009705 H-loop/switch region; other site 525897009706 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 525897009707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897009708 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 525897009709 Walker A/P-loop; other site 525897009710 ATP binding site [chemical binding]; other site 525897009711 Q-loop/lid; other site 525897009712 ABC transporter signature motif; other site 525897009713 Walker B; other site 525897009714 D-loop; other site 525897009715 H-loop/switch region; other site 525897009716 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525897009717 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525897009718 Walker A/P-loop; other site 525897009719 ATP binding site [chemical binding]; other site 525897009720 ABC transporter signature motif; other site 525897009721 Walker B; other site 525897009722 D-loop; other site 525897009723 H-loop/switch region; other site 525897009724 Uncharacterized conserved protein [Function unknown]; Region: COG2353 525897009725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525897009726 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 525897009727 NAD(P) binding site [chemical binding]; other site 525897009728 active site 525897009729 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525897009730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525897009731 non-specific DNA binding site [nucleotide binding]; other site 525897009732 salt bridge; other site 525897009733 sequence-specific DNA binding site [nucleotide binding]; other site 525897009734 Domain of unknown function (DUF955); Region: DUF955; cl01076 525897009735 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 525897009736 putative active site [active] 525897009737 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 525897009738 Response regulator receiver domain; Region: Response_reg; pfam00072 525897009739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897009740 active site 525897009741 phosphorylation site [posttranslational modification] 525897009742 intermolecular recognition site; other site 525897009743 dimerization interface [polypeptide binding]; other site 525897009744 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897009745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897009746 dimer interface [polypeptide binding]; other site 525897009747 phosphorylation site [posttranslational modification] 525897009748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897009749 ATP binding site [chemical binding]; other site 525897009750 Mg2+ binding site [ion binding]; other site 525897009751 G-X-G motif; other site 525897009752 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 525897009753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897009754 active site 525897009755 phosphorylation site [posttranslational modification] 525897009756 intermolecular recognition site; other site 525897009757 dimerization interface [polypeptide binding]; other site 525897009758 endonuclease IV; Provisional; Region: PRK01060 525897009759 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 525897009760 AP (apurinic/apyrimidinic) site pocket; other site 525897009761 DNA interaction; other site 525897009762 Metal-binding active site; metal-binding site 525897009763 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 525897009764 HAMP domain; Region: HAMP; pfam00672 525897009765 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525897009766 dimer interface [polypeptide binding]; other site 525897009767 putative CheW interface [polypeptide binding]; other site 525897009768 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897009769 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897009770 thiosulfate reductase PhsA; Provisional; Region: PRK15488 525897009771 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 525897009772 putative [Fe4-S4] binding site [ion binding]; other site 525897009773 putative molybdopterin cofactor binding site [chemical binding]; other site 525897009774 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 525897009775 putative molybdopterin cofactor binding site; other site 525897009776 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 525897009777 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 525897009778 NlpC/P60 family; Region: NLPC_P60; cl17555 525897009779 Uncharacterized conserved protein [Function unknown]; Region: COG1284 525897009780 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 525897009781 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 525897009782 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 525897009783 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 525897009784 CoA binding domain; Region: CoA_binding_2; pfam13380 525897009785 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 525897009786 hypothetical protein; Provisional; Region: PRK09256 525897009787 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 525897009788 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 525897009789 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 525897009790 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897009791 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897009792 metal binding site [ion binding]; metal-binding site 525897009793 active site 525897009794 I-site; other site 525897009795 PilZ domain; Region: PilZ; pfam07238 525897009796 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 525897009797 NodB motif; other site 525897009798 putative active site [active] 525897009799 putative catalytic site [active] 525897009800 Zn binding site [ion binding]; other site 525897009801 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 525897009802 C-terminal peptidase (prc); Region: prc; TIGR00225 525897009803 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 525897009804 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 525897009805 Catalytic dyad [active] 525897009806 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 525897009807 Peptidase family M23; Region: Peptidase_M23; pfam01551 525897009808 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 525897009809 endonuclease III; Region: ENDO3c; smart00478 525897009810 minor groove reading motif; other site 525897009811 helix-hairpin-helix signature motif; other site 525897009812 substrate binding pocket [chemical binding]; other site 525897009813 active site 525897009814 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 525897009815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897009816 S-adenosylmethionine binding site [chemical binding]; other site 525897009817 acetylornithine aminotransferase; Provisional; Region: PRK02627 525897009818 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 525897009819 inhibitor-cofactor binding pocket; inhibition site 525897009820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897009821 catalytic residue [active] 525897009822 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 525897009823 trimer interface [polypeptide binding]; other site 525897009824 active site 525897009825 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 525897009826 putative homodimer interface [polypeptide binding]; other site 525897009827 putative active site pocket [active] 525897009828 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 525897009829 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 525897009830 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525897009831 RNA binding surface [nucleotide binding]; other site 525897009832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897009833 S-adenosylmethionine binding site [chemical binding]; other site 525897009834 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 525897009835 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 525897009836 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 525897009837 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 525897009838 Tetramer interface [polypeptide binding]; other site 525897009839 active site 525897009840 FMN-binding site [chemical binding]; other site 525897009841 Uncharacterized conserved protein [Function unknown]; Region: COG1434 525897009842 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 525897009843 putative active site [active] 525897009844 Rhomboid family; Region: Rhomboid; cl11446 525897009845 CoA binding domain; Region: CoA_binding_2; pfam13380 525897009846 GrpE; Region: GrpE; pfam01025 525897009847 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 525897009848 dimer interface [polypeptide binding]; other site 525897009849 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 525897009850 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 525897009851 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 525897009852 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 525897009853 NADP binding site [chemical binding]; other site 525897009854 active site 525897009855 putative substrate binding site [chemical binding]; other site 525897009856 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 525897009857 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 525897009858 NAD binding site [chemical binding]; other site 525897009859 substrate binding site [chemical binding]; other site 525897009860 homodimer interface [polypeptide binding]; other site 525897009861 active site 525897009862 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 525897009863 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 525897009864 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 525897009865 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 525897009866 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 525897009867 pyrroline-5-carboxylate reductase; Region: PLN02688 525897009868 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 525897009869 active site 525897009870 multimer interface [polypeptide binding]; other site 525897009871 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 525897009872 GAF domain; Region: GAF; pfam01590 525897009873 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 525897009874 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 525897009875 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 525897009876 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 525897009877 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 525897009878 nucleotide binding site [chemical binding]; other site 525897009879 NEF interaction site [polypeptide binding]; other site 525897009880 SBD interface [polypeptide binding]; other site 525897009881 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 525897009882 putative ligand binding site [chemical binding]; other site 525897009883 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 525897009884 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 525897009885 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 525897009886 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 525897009887 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 525897009888 Ligand Binding Site [chemical binding]; other site 525897009889 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 525897009890 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 525897009891 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897009892 FeS/SAM binding site; other site 525897009893 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 525897009894 hypothetical protein; Provisional; Region: PRK11820 525897009895 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 525897009896 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 525897009897 hypothetical protein; Provisional; Region: PRK04323 525897009898 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 525897009899 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 525897009900 catalytic site [active] 525897009901 G-X2-G-X-G-K; other site 525897009902 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 525897009903 active site 525897009904 dimer interface [polypeptide binding]; other site 525897009905 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525897009906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897009907 binding surface 525897009908 TPR motif; other site 525897009909 TPR repeat; Region: TPR_11; pfam13414 525897009910 PilZ domain; Region: PilZ; pfam07238 525897009911 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 525897009912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525897009913 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525897009914 DNA binding residues [nucleotide binding] 525897009915 dimerization interface [polypeptide binding]; other site 525897009916 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 525897009917 Radical SAM superfamily; Region: Radical_SAM; pfam04055 525897009918 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 525897009919 elongation factor G; Reviewed; Region: PRK12740 525897009920 G1 box; other site 525897009921 putative GEF interaction site [polypeptide binding]; other site 525897009922 GTP/Mg2+ binding site [chemical binding]; other site 525897009923 Switch I region; other site 525897009924 G2 box; other site 525897009925 G3 box; other site 525897009926 Switch II region; other site 525897009927 G4 box; other site 525897009928 G5 box; other site 525897009929 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 525897009930 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 525897009931 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 525897009932 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 525897009933 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 525897009934 putative substrate binding site [chemical binding]; other site 525897009935 putative ATP binding site [chemical binding]; other site 525897009936 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 525897009937 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 525897009938 putative ADP-binding pocket [chemical binding]; other site 525897009939 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 525897009940 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 525897009941 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 525897009942 trehalose synthase; Region: treS_nterm; TIGR02456 525897009943 active site 525897009944 catalytic site [active] 525897009945 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 525897009946 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 525897009947 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 525897009948 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 525897009949 UbiA prenyltransferase family; Region: UbiA; pfam01040 525897009950 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 525897009951 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 525897009952 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 525897009953 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 525897009954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897009955 dimer interface [polypeptide binding]; other site 525897009956 conserved gate region; other site 525897009957 putative PBP binding loops; other site 525897009958 ABC-ATPase subunit interface; other site 525897009959 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 525897009960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897009961 dimer interface [polypeptide binding]; other site 525897009962 conserved gate region; other site 525897009963 putative PBP binding loops; other site 525897009964 ABC-ATPase subunit interface; other site 525897009965 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 525897009966 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525897009967 Walker A/P-loop; other site 525897009968 ATP binding site [chemical binding]; other site 525897009969 Q-loop/lid; other site 525897009970 ABC transporter signature motif; other site 525897009971 Walker B; other site 525897009972 D-loop; other site 525897009973 H-loop/switch region; other site 525897009974 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 525897009975 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 525897009976 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525897009977 Walker A/P-loop; other site 525897009978 ATP binding site [chemical binding]; other site 525897009979 Q-loop/lid; other site 525897009980 ABC transporter signature motif; other site 525897009981 Walker B; other site 525897009982 D-loop; other site 525897009983 H-loop/switch region; other site 525897009984 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 525897009985 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 525897009986 SxDxEG motif; other site 525897009987 active site 525897009988 metal binding site [ion binding]; metal-binding site 525897009989 homopentamer interface [polypeptide binding]; other site 525897009990 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 525897009991 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 525897009992 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 525897009993 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 525897009994 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 525897009995 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 525897009996 DctM-like transporters; Region: DctM; pfam06808 525897009997 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 525897009998 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 525897009999 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 525897010000 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 525897010001 putative ligand binding site [chemical binding]; other site 525897010002 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 525897010003 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 525897010004 Walker A/P-loop; other site 525897010005 ATP binding site [chemical binding]; other site 525897010006 Q-loop/lid; other site 525897010007 ABC transporter signature motif; other site 525897010008 Walker B; other site 525897010009 D-loop; other site 525897010010 H-loop/switch region; other site 525897010011 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 525897010012 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525897010013 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 525897010014 TM-ABC transporter signature motif; other site 525897010015 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525897010016 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 525897010017 TM-ABC transporter signature motif; other site 525897010018 cytosine deaminase; Validated; Region: PRK07572 525897010019 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 525897010020 active site 525897010021 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 525897010022 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 525897010023 negative regulator GrlR; Provisional; Region: PRK14051 525897010024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525897010025 Major Facilitator Superfamily; Region: MFS_1; pfam07690 525897010026 putative substrate translocation pore; other site 525897010027 hybrid cluster protein; Provisional; Region: PRK05290 525897010028 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897010029 ACS interaction site; other site 525897010030 CODH interaction site; other site 525897010031 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 525897010032 hybrid metal cluster; other site 525897010033 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897010034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897010035 active site 525897010036 phosphorylation site [posttranslational modification] 525897010037 intermolecular recognition site; other site 525897010038 dimerization interface [polypeptide binding]; other site 525897010039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897010040 Walker A motif; other site 525897010041 ATP binding site [chemical binding]; other site 525897010042 Walker B motif; other site 525897010043 arginine finger; other site 525897010044 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897010045 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897010046 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897010047 putative active site [active] 525897010048 heme pocket [chemical binding]; other site 525897010049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897010050 dimer interface [polypeptide binding]; other site 525897010051 phosphorylation site [posttranslational modification] 525897010052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897010053 ATP binding site [chemical binding]; other site 525897010054 Mg2+ binding site [ion binding]; other site 525897010055 G-X-G motif; other site 525897010056 Short C-terminal domain; Region: SHOCT; pfam09851 525897010057 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 525897010058 dimer interface [polypeptide binding]; other site 525897010059 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 525897010060 EamA-like transporter family; Region: EamA; pfam00892 525897010061 EamA-like transporter family; Region: EamA; pfam00892 525897010062 MarC family integral membrane protein; Region: MarC; pfam01914 525897010063 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525897010064 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897010065 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525897010066 Phospholipid methyltransferase; Region: PEMT; cl17370 525897010067 multidrug efflux protein; Reviewed; Region: PRK09579 525897010068 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 525897010069 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525897010070 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897010071 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 525897010072 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 525897010073 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897010074 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897010075 putative active site [active] 525897010076 heme pocket [chemical binding]; other site 525897010077 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897010078 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897010079 putative active site [active] 525897010080 heme pocket [chemical binding]; other site 525897010081 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897010082 putative active site [active] 525897010083 heme pocket [chemical binding]; other site 525897010084 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 525897010085 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 525897010086 putative active site [active] 525897010087 catalytic site [active] 525897010088 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 525897010089 putative active site [active] 525897010090 catalytic site [active] 525897010091 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 525897010092 DsrC like protein; Region: DsrC; pfam04358 525897010093 4-alpha-glucanotransferase; Provisional; Region: PRK14508 525897010094 glycogen branching enzyme; Provisional; Region: PRK12313 525897010095 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 525897010096 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 525897010097 active site 525897010098 catalytic site [active] 525897010099 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 525897010100 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 525897010101 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897010102 FeS/SAM binding site; other site 525897010103 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 525897010104 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 525897010105 RNA binding site [nucleotide binding]; other site 525897010106 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 525897010107 RNA binding site [nucleotide binding]; other site 525897010108 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 525897010109 RNA binding site [nucleotide binding]; other site 525897010110 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 525897010111 RNA binding site [nucleotide binding]; other site 525897010112 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 525897010113 RNA binding site [nucleotide binding]; other site 525897010114 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 525897010115 RNA binding site [nucleotide binding]; other site 525897010116 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 525897010117 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 525897010118 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 525897010119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897010120 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 525897010121 FeS/SAM binding site; other site 525897010122 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 525897010123 IHF - DNA interface [nucleotide binding]; other site 525897010124 IHF dimer interface [polypeptide binding]; other site 525897010125 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 525897010126 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 525897010127 Sporulation related domain; Region: SPOR; pfam05036 525897010128 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 525897010129 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 525897010130 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 525897010131 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 525897010132 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 525897010133 Cl- selectivity filter; other site 525897010134 Cl- binding residues [ion binding]; other site 525897010135 pore gating glutamate residue; other site 525897010136 dimer interface [polypeptide binding]; other site 525897010137 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 525897010138 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 525897010139 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 525897010140 active site 525897010141 Riboflavin kinase; Region: Flavokinase; pfam01687 525897010142 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 525897010143 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525897010144 substrate binding pocket [chemical binding]; other site 525897010145 membrane-bound complex binding site; other site 525897010146 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 525897010147 FOG: CBS domain [General function prediction only]; Region: COG0517 525897010148 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 525897010149 FOG: CBS domain [General function prediction only]; Region: COG0517 525897010150 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 525897010151 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 525897010152 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 525897010153 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 525897010154 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 525897010155 ligand binding site [chemical binding]; other site 525897010156 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 525897010157 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 525897010158 putative metal binding residues [ion binding]; other site 525897010159 signature motif; other site 525897010160 dimer interface [polypeptide binding]; other site 525897010161 active site 525897010162 polyP binding site; other site 525897010163 substrate binding site [chemical binding]; other site 525897010164 acceptor-phosphate pocket; other site 525897010165 CotH protein; Region: CotH; pfam08757 525897010166 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 525897010167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525897010168 putative substrate translocation pore; other site 525897010169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525897010170 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 525897010171 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525897010172 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897010173 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 525897010174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525897010175 ATP binding site [chemical binding]; other site 525897010176 putative Mg++ binding site [ion binding]; other site 525897010177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525897010178 nucleotide binding region [chemical binding]; other site 525897010179 ATP-binding site [chemical binding]; other site 525897010180 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 525897010181 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 525897010182 active site 525897010183 substrate binding site [chemical binding]; other site 525897010184 catalytic site [active] 525897010185 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897010186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897010187 active site 525897010188 phosphorylation site [posttranslational modification] 525897010189 intermolecular recognition site; other site 525897010190 dimerization interface [polypeptide binding]; other site 525897010191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897010192 Walker A motif; other site 525897010193 ATP binding site [chemical binding]; other site 525897010194 Walker B motif; other site 525897010195 arginine finger; other site 525897010196 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 525897010197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897010198 dimer interface [polypeptide binding]; other site 525897010199 phosphorylation site [posttranslational modification] 525897010200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897010201 ATP binding site [chemical binding]; other site 525897010202 Mg2+ binding site [ion binding]; other site 525897010203 G-X-G motif; other site 525897010204 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 525897010205 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 525897010206 active site 525897010207 dimer interface [polypeptide binding]; other site 525897010208 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 525897010209 dimer interface [polypeptide binding]; other site 525897010210 active site 525897010211 aspartate aminotransferase; Provisional; Region: PRK05764 525897010212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525897010213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897010214 homodimer interface [polypeptide binding]; other site 525897010215 catalytic residue [active] 525897010216 HDOD domain; Region: HDOD; pfam08668 525897010217 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 525897010218 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 525897010219 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 525897010220 Walker A motif; other site 525897010221 ATP binding site [chemical binding]; other site 525897010222 Walker B motif; other site 525897010223 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 525897010224 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 525897010225 DNA binding residues [nucleotide binding] 525897010226 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 525897010227 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 525897010228 putative tRNA-binding site [nucleotide binding]; other site 525897010229 B3/4 domain; Region: B3_4; pfam03483 525897010230 tRNA synthetase B5 domain; Region: B5; smart00874 525897010231 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 525897010232 dimer interface [polypeptide binding]; other site 525897010233 motif 1; other site 525897010234 motif 3; other site 525897010235 motif 2; other site 525897010236 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 525897010237 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 525897010238 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 525897010239 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 525897010240 dimer interface [polypeptide binding]; other site 525897010241 motif 1; other site 525897010242 active site 525897010243 motif 2; other site 525897010244 motif 3; other site 525897010245 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 525897010246 23S rRNA binding site [nucleotide binding]; other site 525897010247 L21 binding site [polypeptide binding]; other site 525897010248 L13 binding site [polypeptide binding]; other site 525897010249 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 525897010250 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 525897010251 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 525897010252 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 525897010253 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 525897010254 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 525897010255 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 525897010256 active site 525897010257 dimer interface [polypeptide binding]; other site 525897010258 motif 1; other site 525897010259 motif 2; other site 525897010260 motif 3; other site 525897010261 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 525897010262 anticodon binding site; other site 525897010263 Response regulator receiver domain; Region: Response_reg; pfam00072 525897010264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897010265 active site 525897010266 phosphorylation site [posttranslational modification] 525897010267 intermolecular recognition site; other site 525897010268 dimerization interface [polypeptide binding]; other site 525897010269 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 525897010270 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 525897010271 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 525897010272 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 525897010273 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 525897010274 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 525897010275 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 525897010276 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 525897010277 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 525897010278 inhibitor-cofactor binding pocket; inhibition site 525897010279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897010280 catalytic residue [active] 525897010281 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525897010282 heme-binding residues [chemical binding]; other site 525897010283 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 525897010284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897010285 S-adenosylmethionine binding site [chemical binding]; other site 525897010286 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 525897010287 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 525897010288 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 525897010289 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 525897010290 futalosine nucleosidase; Region: fut_nucase; TIGR03664 525897010291 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 525897010292 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 525897010293 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 525897010294 substrate binding pocket [chemical binding]; other site 525897010295 chain length determination region; other site 525897010296 substrate-Mg2+ binding site; other site 525897010297 catalytic residues [active] 525897010298 aspartate-rich region 1; other site 525897010299 active site lid residues [active] 525897010300 aspartate-rich region 2; other site 525897010301 HDOD domain; Region: HDOD; pfam08668 525897010302 PAS domain; Region: PAS; smart00091 525897010303 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897010304 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897010305 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897010306 metal binding site [ion binding]; metal-binding site 525897010307 active site 525897010308 I-site; other site 525897010309 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 525897010310 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 525897010311 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 525897010312 dimerization interface [polypeptide binding]; other site 525897010313 ATP binding site [chemical binding]; other site 525897010314 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 525897010315 dimerization interface [polypeptide binding]; other site 525897010316 ATP binding site [chemical binding]; other site 525897010317 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 525897010318 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 525897010319 domain interfaces; other site 525897010320 active site 525897010321 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 525897010322 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 525897010323 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 525897010324 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 525897010325 phosphoserine phosphatase SerB; Region: serB; TIGR00338 525897010326 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 525897010327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525897010328 motif II; other site 525897010329 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 525897010330 DNA polymerase III subunit delta'; Validated; Region: PRK08485 525897010331 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 525897010332 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 525897010333 GDP-binding site [chemical binding]; other site 525897010334 ACT binding site; other site 525897010335 IMP binding site; other site 525897010336 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 525897010337 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 525897010338 RNB domain; Region: RNB; pfam00773 525897010339 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 525897010340 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 525897010341 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 525897010342 HflX GTPase family; Region: HflX; cd01878 525897010343 G1 box; other site 525897010344 GTP/Mg2+ binding site [chemical binding]; other site 525897010345 Switch I region; other site 525897010346 G2 box; other site 525897010347 G3 box; other site 525897010348 Switch II region; other site 525897010349 G4 box; other site 525897010350 G5 box; other site 525897010351 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 525897010352 purine monophosphate binding site [chemical binding]; other site 525897010353 dimer interface [polypeptide binding]; other site 525897010354 putative catalytic residues [active] 525897010355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897010356 binding surface 525897010357 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525897010358 TPR motif; other site 525897010359 TPR repeat; Region: TPR_11; pfam13414 525897010360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897010361 TPR motif; other site 525897010362 TPR repeat; Region: TPR_11; pfam13414 525897010363 binding surface 525897010364 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12621 525897010365 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 525897010366 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 525897010367 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 525897010368 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 525897010369 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 525897010370 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 525897010371 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 525897010372 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 525897010373 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 525897010374 MgtE intracellular N domain; Region: MgtE_N; cl15244 525897010375 FliG C-terminal domain; Region: FliG_C; pfam01706 525897010376 Flagellar assembly protein FliH; Region: FliH; pfam02108 525897010377 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 525897010378 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 525897010379 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 525897010380 Walker A motif/ATP binding site; other site 525897010381 Walker B motif; other site 525897010382 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 525897010383 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 525897010384 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 525897010385 Walker A motif; other site 525897010386 ATP binding site [chemical binding]; other site 525897010387 Walker B motif; other site 525897010388 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 525897010389 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 525897010390 active site 525897010391 HIGH motif; other site 525897010392 nucleotide binding site [chemical binding]; other site 525897010393 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 525897010394 Flavoprotein; Region: Flavoprotein; pfam02441 525897010395 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 525897010396 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 525897010397 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 525897010398 putative NAD(P) binding site [chemical binding]; other site 525897010399 active site 525897010400 putative substrate binding site [chemical binding]; other site 525897010401 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 525897010402 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 525897010403 P-loop; other site 525897010404 Magnesium ion binding site [ion binding]; other site 525897010405 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 525897010406 Magnesium ion binding site [ion binding]; other site 525897010407 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 525897010408 ParB-like nuclease domain; Region: ParB; smart00470 525897010409 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 525897010410 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 525897010411 putative ribose interaction site [chemical binding]; other site 525897010412 putative ADP binding site [chemical binding]; other site 525897010413 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 525897010414 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 525897010415 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 525897010416 metal binding triad; other site 525897010417 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 525897010418 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 525897010419 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 525897010420 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 525897010421 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 525897010422 Nitrogen regulatory protein P-II; Region: P-II; smart00938 525897010423 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 525897010424 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 525897010425 Nitrogen regulatory protein P-II; Region: P-II; smart00938 525897010426 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 525897010427 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 525897010428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897010429 FeS/SAM binding site; other site 525897010430 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 525897010431 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 525897010432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525897010433 DNA-binding site [nucleotide binding]; DNA binding site 525897010434 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525897010435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897010436 homodimer interface [polypeptide binding]; other site 525897010437 catalytic residue [active] 525897010438 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 525897010439 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 525897010440 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 525897010441 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525897010442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897010443 homodimer interface [polypeptide binding]; other site 525897010444 catalytic residue [active] 525897010445 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 525897010446 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525897010447 HlyD family secretion protein; Region: HlyD_3; pfam13437 525897010448 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 525897010449 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 525897010450 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 525897010451 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 525897010452 putative RNA binding site [nucleotide binding]; other site 525897010453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897010454 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 525897010455 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 525897010456 Malic enzyme, N-terminal domain; Region: malic; pfam00390 525897010457 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 525897010458 putative NAD(P) binding site [chemical binding]; other site 525897010459 Fumarase C-terminus; Region: Fumerase_C; cl00795 525897010460 fumarate hydratase; Provisional; Region: PRK06246 525897010461 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 525897010462 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 525897010463 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 525897010464 L-aspartate oxidase; Provisional; Region: PRK06175 525897010465 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 525897010466 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 525897010467 Iron-sulfur protein interface; other site 525897010468 proximal heme binding site [chemical binding]; other site 525897010469 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 525897010470 distal heme binding site [chemical binding]; other site 525897010471 dimer interface [polypeptide binding]; other site 525897010472 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 525897010473 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 525897010474 metal-binding site [ion binding] 525897010475 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 525897010476 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 525897010477 metal-binding site [ion binding] 525897010478 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 525897010479 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525897010480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525897010481 motif II; other site 525897010482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525897010483 HDOD domain; Region: HDOD; pfam08668 525897010484 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897010485 Zn2+ binding site [ion binding]; other site 525897010486 Mg2+ binding site [ion binding]; other site 525897010487 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 525897010488 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 525897010489 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 525897010490 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 525897010491 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 525897010492 hexamer interface [polypeptide binding]; other site 525897010493 ligand binding site [chemical binding]; other site 525897010494 putative active site [active] 525897010495 NAD(P) binding site [chemical binding]; other site 525897010496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 525897010497 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 525897010498 Walker A/P-loop; other site 525897010499 ATP binding site [chemical binding]; other site 525897010500 Q-loop/lid; other site 525897010501 ABC transporter signature motif; other site 525897010502 Walker B; other site 525897010503 D-loop; other site 525897010504 H-loop/switch region; other site 525897010505 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 525897010506 Protein of unknown function, DUF486; Region: DUF486; cl01236 525897010507 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 525897010508 putative FMN binding site [chemical binding]; other site 525897010509 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 525897010510 putative uracil binding site [chemical binding]; other site 525897010511 putative active site [active] 525897010512 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 525897010513 hypothetical protein; Provisional; Region: PRK10279 525897010514 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 525897010515 active site 525897010516 nucleophile elbow; other site 525897010517 protease3; Provisional; Region: PRK15101 525897010518 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 525897010519 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 525897010520 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 525897010521 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897010522 FeS/SAM binding site; other site 525897010523 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 525897010524 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 525897010525 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 525897010526 dimer interface [polypeptide binding]; other site 525897010527 PYR/PP interface [polypeptide binding]; other site 525897010528 TPP binding site [chemical binding]; other site 525897010529 substrate binding site [chemical binding]; other site 525897010530 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 525897010531 TPP-binding site [chemical binding]; other site 525897010532 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 525897010533 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 525897010534 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 525897010535 ATP-grasp domain; Region: ATP-grasp; pfam02222 525897010536 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 525897010537 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 525897010538 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 525897010539 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 525897010540 putative dimerization interface [polypeptide binding]; other site 525897010541 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 525897010542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897010543 TPR motif; other site 525897010544 binding surface 525897010545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897010546 binding surface 525897010547 TPR motif; other site 525897010548 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 525897010549 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 525897010550 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 525897010551 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 525897010552 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14460 525897010553 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897010554 FeS/SAM binding site; other site 525897010555 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 525897010556 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897010557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897010558 active site 525897010559 phosphorylation site [posttranslational modification] 525897010560 intermolecular recognition site; other site 525897010561 dimerization interface [polypeptide binding]; other site 525897010562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897010563 Walker A motif; other site 525897010564 ATP binding site [chemical binding]; other site 525897010565 Walker B motif; other site 525897010566 arginine finger; other site 525897010567 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897010568 dihydroorotase; Validated; Region: pyrC; PRK09357 525897010569 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 525897010570 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 525897010571 active site 525897010572 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 525897010573 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 525897010574 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 525897010575 DNA gyrase subunit A; Validated; Region: PRK05560 525897010576 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 525897010577 CAP-like domain; other site 525897010578 active site 525897010579 primary dimer interface [polypeptide binding]; other site 525897010580 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525897010581 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525897010582 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525897010583 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525897010584 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525897010585 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 525897010586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897010587 Mg2+ binding site [ion binding]; other site 525897010588 G-X-G motif; other site 525897010589 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 525897010590 anchoring element; other site 525897010591 dimer interface [polypeptide binding]; other site 525897010592 ATP binding site [chemical binding]; other site 525897010593 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 525897010594 active site 525897010595 putative metal-binding site [ion binding]; other site 525897010596 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 525897010597 DNA polymerase III subunit beta; Provisional; Region: PRK14947 525897010598 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 525897010599 putative DNA binding surface [nucleotide binding]; other site 525897010600 dimer interface [polypeptide binding]; other site 525897010601 beta-clamp/clamp loader binding surface; other site 525897010602 beta-clamp/translesion DNA polymerase binding surface; other site 525897010603 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 525897010604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897010605 Walker A motif; other site 525897010606 ATP binding site [chemical binding]; other site 525897010607 Walker B motif; other site 525897010608 arginine finger; other site 525897010609 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 525897010610 DnaA box-binding interface [nucleotide binding]; other site 525897010611 Domain of unknown function DUF39; Region: DUF39; pfam01837 525897010612 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 525897010613 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 525897010614 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 525897010615 adenylosuccinate lyase; Provisional; Region: PRK07492 525897010616 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 525897010617 tetramer interface [polypeptide binding]; other site 525897010618 active site 525897010619 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 525897010620 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525897010621 active site 525897010622 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 525897010623 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 525897010624 Fic family protein [Function unknown]; Region: COG3177 525897010625 Fic/DOC family; Region: Fic; pfam02661 525897010626 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 525897010627 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 525897010628 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525897010629 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 525897010630 active site 525897010631 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 525897010632 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 525897010633 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 525897010634 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 525897010635 putative active site; other site 525897010636 catalytic residue [active] 525897010637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897010638 S-adenosylmethionine binding site [chemical binding]; other site 525897010639 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 525897010640 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 525897010641 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 525897010642 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525897010643 Walker A/P-loop; other site 525897010644 ATP binding site [chemical binding]; other site 525897010645 Q-loop/lid; other site 525897010646 ABC transporter signature motif; other site 525897010647 Walker B; other site 525897010648 D-loop; other site 525897010649 H-loop/switch region; other site 525897010650 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 525897010651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897010652 active site 525897010653 phosphorylation site [posttranslational modification] 525897010654 intermolecular recognition site; other site 525897010655 dimerization interface [polypeptide binding]; other site 525897010656 TPR repeat; Region: TPR_11; pfam13414 525897010657 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897010658 binding surface 525897010659 TPR motif; other site 525897010660 TPR repeat; Region: TPR_11; pfam13414 525897010661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897010662 binding surface 525897010663 TPR motif; other site 525897010664 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 525897010665 GAF domain; Region: GAF_2; pfam13185 525897010666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897010667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897010668 dimer interface [polypeptide binding]; other site 525897010669 phosphorylation site [posttranslational modification] 525897010670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897010671 ATP binding site [chemical binding]; other site 525897010672 Mg2+ binding site [ion binding]; other site 525897010673 G-X-G motif; other site 525897010674 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 525897010675 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 525897010676 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 525897010677 active site 525897010678 dimer interface [polypeptide binding]; other site 525897010679 effector binding site; other site 525897010680 TSCPD domain; Region: TSCPD; pfam12637 525897010681 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 525897010682 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 525897010683 substrate binding site; other site 525897010684 tetramer interface; other site 525897010685 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 525897010686 MPT binding site; other site 525897010687 trimer interface [polypeptide binding]; other site 525897010688 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 525897010689 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897010690 PAS domain; Region: PAS; smart00091 525897010691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897010692 dimer interface [polypeptide binding]; other site 525897010693 phosphorylation site [posttranslational modification] 525897010694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897010695 ATP binding site [chemical binding]; other site 525897010696 Mg2+ binding site [ion binding]; other site 525897010697 G-X-G motif; other site 525897010698 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 525897010699 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 525897010700 PHP-associated; Region: PHP_C; pfam13263 525897010701 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 525897010702 Part of AAA domain; Region: AAA_19; pfam13245 525897010703 Family description; Region: UvrD_C_2; pfam13538 525897010704 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 525897010705 Walker A motif; other site 525897010706 ATP binding site [chemical binding]; other site 525897010707 Walker B motif; other site 525897010708 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 525897010709 DHH family; Region: DHH; pfam01368 525897010710 DNA polymerase I; Provisional; Region: PRK05755 525897010711 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 525897010712 active site 525897010713 metal binding site 1 [ion binding]; metal-binding site 525897010714 putative 5' ssDNA interaction site; other site 525897010715 metal binding site 3; metal-binding site 525897010716 metal binding site 2 [ion binding]; metal-binding site 525897010717 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 525897010718 putative DNA binding site [nucleotide binding]; other site 525897010719 putative metal binding site [ion binding]; other site 525897010720 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 525897010721 active site 525897010722 DNA binding site [nucleotide binding] 525897010723 catalytic site [active] 525897010724 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 525897010725 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525897010726 catalytic residue [active] 525897010727 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 525897010728 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 525897010729 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 525897010730 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 525897010731 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 525897010732 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 525897010733 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 525897010734 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 525897010735 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 525897010736 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 525897010737 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 525897010738 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 525897010739 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 525897010740 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525897010741 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525897010742 Walker A/P-loop; other site 525897010743 ATP binding site [chemical binding]; other site 525897010744 Q-loop/lid; other site 525897010745 ABC transporter signature motif; other site 525897010746 Walker B; other site 525897010747 D-loop; other site 525897010748 H-loop/switch region; other site 525897010749 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 525897010750 cobalt transport protein CbiM; Validated; Region: PRK06265 525897010751 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 525897010752 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 525897010753 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 525897010754 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 525897010755 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 525897010756 ATP binding site [chemical binding]; other site 525897010757 putative Mg++ binding site [ion binding]; other site 525897010758 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525897010759 nucleotide binding region [chemical binding]; other site 525897010760 ATP-binding site [chemical binding]; other site 525897010761 CHASE4 domain; Region: CHASE4; pfam05228 525897010762 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525897010763 dimerization interface [polypeptide binding]; other site 525897010764 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897010765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897010766 metal binding site [ion binding]; metal-binding site 525897010767 active site 525897010768 I-site; other site 525897010769 LysE type translocator; Region: LysE; cl00565 525897010770 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 525897010771 putative tRNA-binding site [nucleotide binding]; other site 525897010772 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 525897010773 Transcriptional regulators [Transcription]; Region: FadR; COG2186 525897010774 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525897010775 DNA-binding site [nucleotide binding]; DNA binding site 525897010776 FCD domain; Region: FCD; pfam07729 525897010777 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 525897010778 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 525897010779 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 525897010780 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 525897010781 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 525897010782 Ligand binding site; other site 525897010783 Putative Catalytic site; other site 525897010784 DXD motif; other site 525897010785 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 525897010786 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 525897010787 active site 525897010788 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 525897010789 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 525897010790 Ribonuclease P; Region: Ribonuclease_P; pfam00825 525897010791 Haemolytic domain; Region: Haemolytic; pfam01809 525897010792 membrane protein insertase; Provisional; Region: PRK01318 525897010793 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 525897010794 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 525897010795 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 525897010796 G-X-X-G motif; other site 525897010797 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 525897010798 RxxxH motif; other site 525897010799 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 525897010800 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 525897010801 trmE is a tRNA modification GTPase; Region: trmE; cd04164 525897010802 G1 box; other site 525897010803 GTP/Mg2+ binding site [chemical binding]; other site 525897010804 Switch I region; other site 525897010805 G2 box; other site 525897010806 Switch II region; other site 525897010807 G3 box; other site 525897010808 G4 box; other site 525897010809 G5 box; other site 525897010810 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 525897010811 ribonuclease R; Region: RNase_R; TIGR02063 525897010812 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 525897010813 RNB domain; Region: RNB; pfam00773 525897010814 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 525897010815 RNA binding site [nucleotide binding]; other site 525897010816 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 525897010817 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 525897010818 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 525897010819 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 525897010820 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 525897010821 CoA binding domain; Region: CoA_binding_2; pfam13380 525897010822 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 525897010823 four helix bundle protein; Region: TIGR02436 525897010824 four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258 525897010825 acetyl-CoA synthetase; Provisional; Region: PRK00174 525897010826 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 525897010827 active site 525897010828 CoA binding site [chemical binding]; other site 525897010829 acyl-activating enzyme (AAE) consensus motif; other site 525897010830 AMP binding site [chemical binding]; other site 525897010831 acetate binding site [chemical binding]; other site 525897010832 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 525897010833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897010834 active site 525897010835 phosphorylation site [posttranslational modification] 525897010836 intermolecular recognition site; other site 525897010837 dimerization interface [polypeptide binding]; other site 525897010838 LytTr DNA-binding domain; Region: LytTR; smart00850 525897010839 GTP-binding protein LepA; Provisional; Region: PRK05433 525897010840 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 525897010841 G1 box; other site 525897010842 putative GEF interaction site [polypeptide binding]; other site 525897010843 GTP/Mg2+ binding site [chemical binding]; other site 525897010844 Switch I region; other site 525897010845 G2 box; other site 525897010846 G3 box; other site 525897010847 Switch II region; other site 525897010848 G4 box; other site 525897010849 G5 box; other site 525897010850 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 525897010851 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 525897010852 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 525897010853 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 525897010854 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 525897010855 Catalytic site [active] 525897010856 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 525897010857 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 525897010858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897010859 Walker A motif; other site 525897010860 ATP binding site [chemical binding]; other site 525897010861 Walker B motif; other site 525897010862 arginine finger; other site 525897010863 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 525897010864 Peptidase family M48; Region: Peptidase_M48; pfam01435 525897010865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897010866 TPR motif; other site 525897010867 binding surface 525897010868 Mechanosensitive ion channel; Region: MS_channel; pfam00924 525897010869 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 525897010870 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 525897010871 active site 525897010872 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 525897010873 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 525897010874 putative ATP binding site [chemical binding]; other site 525897010875 putative substrate interface [chemical binding]; other site 525897010876 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 525897010877 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 525897010878 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 525897010879 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 525897010880 Ligand Binding Site [chemical binding]; other site 525897010881 recombinase A; Provisional; Region: recA; PRK09354 525897010882 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 525897010883 hexamer interface [polypeptide binding]; other site 525897010884 Walker A motif; other site 525897010885 ATP binding site [chemical binding]; other site 525897010886 Walker B motif; other site 525897010887 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 525897010888 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 525897010889 motif 1; other site 525897010890 active site 525897010891 motif 2; other site 525897010892 motif 3; other site 525897010893 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 525897010894 DHHA1 domain; Region: DHHA1; pfam02272 525897010895 PSP1 C-terminal conserved region; Region: PSP1; cl00770 525897010896 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 525897010897 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 525897010898 active site 525897010899 HIGH motif; other site 525897010900 KMSKS motif; other site 525897010901 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 525897010902 tRNA binding surface [nucleotide binding]; other site 525897010903 anticodon binding site; other site 525897010904 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 525897010905 dimer interface [polypeptide binding]; other site 525897010906 putative tRNA-binding site [nucleotide binding]; other site 525897010907 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 525897010908 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 525897010909 Potassium binding sites [ion binding]; other site 525897010910 Cesium cation binding sites [ion binding]; other site 525897010911 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 525897010912 FAD binding domain; Region: FAD_binding_4; pfam01565 525897010913 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 525897010914 Rrf2 family protein; Region: rrf2_super; TIGR00738 525897010915 Transcriptional regulator; Region: Rrf2; cl17282 525897010916 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 525897010917 heterotetramer interface [polypeptide binding]; other site 525897010918 active site pocket [active] 525897010919 cleavage site 525897010920 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897010921 Zn2+ binding site [ion binding]; other site 525897010922 Mg2+ binding site [ion binding]; other site 525897010923 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 525897010924 active site 525897010925 metal binding site [ion binding]; metal-binding site 525897010926 homotetramer interface [polypeptide binding]; other site 525897010927 SurA N-terminal domain; Region: SurA_N_3; cl07813 525897010928 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 525897010929 aconitate hydratase; Validated; Region: PRK07229 525897010930 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 525897010931 substrate binding site [chemical binding]; other site 525897010932 ligand binding site [chemical binding]; other site 525897010933 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 525897010934 substrate binding site [chemical binding]; other site 525897010935 Chorismate mutase type II; Region: CM_2; cl00693 525897010936 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 525897010937 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 525897010938 ATP-sulfurylase; Region: ATPS; cd00517 525897010939 active site 525897010940 HXXH motif; other site 525897010941 flexible loop; other site 525897010942 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 525897010943 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 525897010944 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 525897010945 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 525897010946 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 525897010947 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 525897010948 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525897010949 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 525897010950 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 525897010951 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897010952 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 525897010953 EVE domain; Region: EVE; cl00728 525897010954 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 525897010955 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 525897010956 Walker A/P-loop; other site 525897010957 ATP binding site [chemical binding]; other site 525897010958 Q-loop/lid; other site 525897010959 ABC transporter signature motif; other site 525897010960 Walker B; other site 525897010961 D-loop; other site 525897010962 H-loop/switch region; other site 525897010963 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 525897010964 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 525897010965 Walker A/P-loop; other site 525897010966 ATP binding site [chemical binding]; other site 525897010967 Q-loop/lid; other site 525897010968 ABC transporter signature motif; other site 525897010969 Walker B; other site 525897010970 D-loop; other site 525897010971 H-loop/switch region; other site 525897010972 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 525897010973 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 525897010974 TM-ABC transporter signature motif; other site 525897010975 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525897010976 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 525897010977 TM-ABC transporter signature motif; other site 525897010978 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 525897010979 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 525897010980 dimerization interface [polypeptide binding]; other site 525897010981 ligand binding site [chemical binding]; other site 525897010982 Proline dehydrogenase; Region: Pro_dh; cl03282 525897010983 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 525897010984 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 525897010985 Glutamate binding site [chemical binding]; other site 525897010986 homodimer interface [polypeptide binding]; other site 525897010987 NAD binding site [chemical binding]; other site 525897010988 catalytic residues [active] 525897010989 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 525897010990 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525897010991 putative DNA binding site [nucleotide binding]; other site 525897010992 putative Zn2+ binding site [ion binding]; other site 525897010993 AsnC family; Region: AsnC_trans_reg; pfam01037 525897010994 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 525897010995 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 525897010996 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 525897010997 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 525897010998 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 525897010999 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525897011000 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 525897011001 IMP binding site; other site 525897011002 dimer interface [polypeptide binding]; other site 525897011003 partial ornithine binding site; other site 525897011004 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 525897011005 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 525897011006 active site 525897011007 tetramer interface [polypeptide binding]; other site 525897011008 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525897011009 active site 525897011010 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 525897011011 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 525897011012 putative active site [active] 525897011013 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 525897011014 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 525897011015 Transglycosylase; Region: Transgly; pfam00912 525897011016 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 525897011017 RNA binding site [nucleotide binding]; other site 525897011018 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 525897011019 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 525897011020 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 525897011021 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 525897011022 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 525897011023 active site 525897011024 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 525897011025 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 525897011026 active site 525897011027 Uncharacterized conserved protein [Function unknown]; Region: COG2835 525897011028 pantothenate kinase; Reviewed; Region: PRK13321 525897011029 enolase; Provisional; Region: eno; PRK00077 525897011030 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 525897011031 dimer interface [polypeptide binding]; other site 525897011032 metal binding site [ion binding]; metal-binding site 525897011033 substrate binding pocket [chemical binding]; other site 525897011034 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14184 525897011035 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 525897011036 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 525897011037 homodimer interface [polypeptide binding]; other site 525897011038 NADP binding site [chemical binding]; other site 525897011039 substrate binding site [chemical binding]; other site 525897011040 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 525897011041 putative ligand binding pocket/active site [active] 525897011042 putative metal binding site [ion binding]; other site 525897011043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897011044 binding surface 525897011045 TPR motif; other site 525897011046 Tetratricopeptide repeat; Region: TPR_16; pfam13432 525897011047 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 525897011048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897011049 Walker A motif; other site 525897011050 ATP binding site [chemical binding]; other site 525897011051 Walker B motif; other site 525897011052 arginine finger; other site 525897011053 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897011054 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 525897011055 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 525897011056 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 525897011057 dimerization interface [polypeptide binding]; other site 525897011058 domain crossover interface; other site 525897011059 redox-dependent activation switch; other site 525897011060 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 525897011061 putative GTP cyclohydrolase; Provisional; Region: PRK13674 525897011062 nickel responsive regulator; Provisional; Region: PRK04460 525897011063 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 525897011064 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 525897011065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 525897011066 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 525897011067 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 525897011068 Walker A/P-loop; other site 525897011069 ATP binding site [chemical binding]; other site 525897011070 Q-loop/lid; other site 525897011071 ABC transporter signature motif; other site 525897011072 Walker B; other site 525897011073 D-loop; other site 525897011074 H-loop/switch region; other site 525897011075 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 525897011076 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525897011077 active site 525897011078 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525897011079 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 525897011080 TM-ABC transporter signature motif; other site 525897011081 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525897011082 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 525897011083 TM-ABC transporter signature motif; other site 525897011084 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 525897011085 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 525897011086 putative ligand binding site [chemical binding]; other site 525897011087 PilZ domain; Region: PilZ; pfam07238 525897011088 Putative exonuclease, RdgC; Region: RdgC; cl01122 525897011089 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 525897011090 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 525897011091 active site 525897011092 catalytic site [active] 525897011093 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 525897011094 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 525897011095 Glucose inhibited division protein A; Region: GIDA; pfam01134 525897011096 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 525897011097 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 525897011098 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525897011099 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 525897011100 Soluble P-type ATPase [General function prediction only]; Region: COG4087 525897011101 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 525897011102 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 525897011103 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525897011104 active site 525897011105 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 525897011106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 525897011107 active site 525897011108 phosphorylation site [posttranslational modification] 525897011109 intermolecular recognition site; other site 525897011110 dimerization interface [polypeptide binding]; other site 525897011111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897011112 binding surface 525897011113 TPR motif; other site 525897011114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897011115 binding surface 525897011116 TPR motif; other site 525897011117 TPR repeat; Region: TPR_11; pfam13414 525897011118 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 525897011119 Peptidase family U32; Region: Peptidase_U32; pfam01136 525897011120 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525897011121 dimerization interface [polypeptide binding]; other site 525897011122 putative DNA binding site [nucleotide binding]; other site 525897011123 putative Zn2+ binding site [ion binding]; other site 525897011124 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 525897011125 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 525897011126 NADP-binding site; other site 525897011127 homotetramer interface [polypeptide binding]; other site 525897011128 substrate binding site [chemical binding]; other site 525897011129 homodimer interface [polypeptide binding]; other site 525897011130 active site 525897011131 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 525897011132 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 525897011133 NADP binding site [chemical binding]; other site 525897011134 active site 525897011135 putative substrate binding site [chemical binding]; other site 525897011136 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 525897011137 active site 525897011138 NTP binding site [chemical binding]; other site 525897011139 metal binding triad [ion binding]; metal-binding site 525897011140 antibiotic binding site [chemical binding]; other site 525897011141 Protein of unknown function DUF86; Region: DUF86; pfam01934 525897011142 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 525897011143 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 525897011144 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 525897011145 putative trimer interface [polypeptide binding]; other site 525897011146 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 525897011147 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 525897011148 putative CoA binding site [chemical binding]; other site 525897011149 putative trimer interface [polypeptide binding]; other site 525897011150 putative active site [active] 525897011151 putative substrate binding site [chemical binding]; other site 525897011152 putative CoA binding site [chemical binding]; other site 525897011153 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 525897011154 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 525897011155 inhibitor-cofactor binding pocket; inhibition site 525897011156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897011157 catalytic residue [active] 525897011158 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525897011159 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 525897011160 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 525897011161 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 525897011162 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 525897011163 active site 525897011164 dimer interface [polypeptide binding]; other site 525897011165 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 525897011166 Ligand Binding Site [chemical binding]; other site 525897011167 Molecular Tunnel; other site 525897011168 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897011169 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 525897011170 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 525897011171 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 525897011172 Probable Catalytic site; other site 525897011173 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 525897011174 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 525897011175 Probable Catalytic site; other site 525897011176 metal-binding site 525897011177 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 525897011178 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 525897011179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525897011180 NAD(P) binding site [chemical binding]; other site 525897011181 active site 525897011182 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 525897011183 Mg++ binding site [ion binding]; other site 525897011184 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 525897011185 putative catalytic motif [active] 525897011186 putative substrate binding site [chemical binding]; other site 525897011187 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 525897011188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525897011189 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 525897011190 NAD(P) binding site [chemical binding]; other site 525897011191 homodimer interface [polypeptide binding]; other site 525897011192 substrate binding site [chemical binding]; other site 525897011193 active site 525897011194 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 525897011195 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 525897011196 NADP-binding site; other site 525897011197 homotetramer interface [polypeptide binding]; other site 525897011198 substrate binding site [chemical binding]; other site 525897011199 homodimer interface [polypeptide binding]; other site 525897011200 active site 525897011201 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 525897011202 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 525897011203 NADP binding site [chemical binding]; other site 525897011204 active site 525897011205 putative substrate binding site [chemical binding]; other site 525897011206 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 525897011207 active site 525897011208 NTP binding site [chemical binding]; other site 525897011209 metal binding triad [ion binding]; metal-binding site 525897011210 antibiotic binding site [chemical binding]; other site 525897011211 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525897011212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525897011213 Walker A/P-loop; other site 525897011214 ATP binding site [chemical binding]; other site 525897011215 Q-loop/lid; other site 525897011216 ABC transporter signature motif; other site 525897011217 Walker B; other site 525897011218 D-loop; other site 525897011219 H-loop/switch region; other site 525897011220 Methyltransferase domain; Region: Methyltransf_23; pfam13489 525897011221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 525897011222 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525897011223 active site 525897011224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897011225 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525897011226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897011227 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525897011228 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897011229 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897011230 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525897011231 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 525897011232 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525897011233 active site 525897011234 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 525897011235 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 525897011236 active site 525897011237 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525897011238 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 525897011239 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 525897011240 trimer interface [polypeptide binding]; other site 525897011241 active site 525897011242 substrate binding site [chemical binding]; other site 525897011243 CoA binding site [chemical binding]; other site 525897011244 Methyltransferase domain; Region: Methyltransf_31; pfam13847 525897011245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897011246 S-adenosylmethionine binding site [chemical binding]; other site 525897011247 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 525897011248 extended (e) SDRs; Region: SDR_e; cd08946 525897011249 NAD(P) binding site [chemical binding]; other site 525897011250 active site 525897011251 substrate binding site [chemical binding]; other site 525897011252 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897011253 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525897011254 Transposase; Region: HTH_Tnp_1; pfam01527 525897011255 putative transposase OrfB; Reviewed; Region: PHA02517 525897011256 HTH-like domain; Region: HTH_21; pfam13276 525897011257 Integrase core domain; Region: rve; pfam00665 525897011258 Integrase core domain; Region: rve_3; pfam13683 525897011259 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 525897011260 Bacterial sugar transferase; Region: Bac_transf; pfam02397 525897011261 putative glycosyl transferase; Provisional; Region: PRK10063 525897011262 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525897011263 active site 525897011264 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897011265 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 525897011266 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 525897011267 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 525897011268 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 525897011269 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525897011270 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 525897011271 Walker A/P-loop; other site 525897011272 ATP binding site [chemical binding]; other site 525897011273 Q-loop/lid; other site 525897011274 ABC transporter signature motif; other site 525897011275 Walker B; other site 525897011276 D-loop; other site 525897011277 H-loop/switch region; other site 525897011278 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608 525897011279 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525897011280 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525897011281 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 525897011282 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 525897011283 AIR carboxylase; Region: AIRC; smart01001 525897011284 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897011285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897011286 intermolecular recognition site; other site 525897011287 active site 525897011288 dimerization interface [polypeptide binding]; other site 525897011289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897011290 Walker A motif; other site 525897011291 ATP binding site [chemical binding]; other site 525897011292 Walker B motif; other site 525897011293 arginine finger; other site 525897011294 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897011295 aspartate aminotransferase; Provisional; Region: PRK06836 525897011296 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525897011297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897011298 homodimer interface [polypeptide binding]; other site 525897011299 catalytic residue [active] 525897011300 signal recognition particle protein; Provisional; Region: PRK10867 525897011301 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 525897011302 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 525897011303 P loop; other site 525897011304 GTP binding site [chemical binding]; other site 525897011305 Signal peptide binding domain; Region: SRP_SPB; pfam02978 525897011306 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 525897011307 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 525897011308 hypothetical protein; Provisional; Region: PRK00468 525897011309 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 525897011310 RimM N-terminal domain; Region: RimM; pfam01782 525897011311 PRC-barrel domain; Region: PRC; pfam05239 525897011312 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 525897011313 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 525897011314 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 525897011315 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 525897011316 RNA/DNA hybrid binding site [nucleotide binding]; other site 525897011317 active site 525897011318 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 525897011319 Predicted methyltransferases [General function prediction only]; Region: COG0313 525897011320 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 525897011321 putative SAM binding site [chemical binding]; other site 525897011322 putative homodimer interface [polypeptide binding]; other site 525897011323 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 525897011324 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 525897011325 dimerization domain swap beta strand [polypeptide binding]; other site 525897011326 regulatory protein interface [polypeptide binding]; other site 525897011327 active site 525897011328 regulatory phosphorylation site [posttranslational modification]; other site 525897011329 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 525897011330 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 525897011331 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 525897011332 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 525897011333 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 525897011334 SmpB-tmRNA interface; other site 525897011335 Isochorismatase family; Region: Isochorismatase; pfam00857 525897011336 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 525897011337 catalytic triad [active] 525897011338 conserved cis-peptide bond; other site 525897011339 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 525897011340 DEAD/DEAH box helicase; Region: DEAD; pfam00270 525897011341 ATP binding site [chemical binding]; other site 525897011342 putative Mg++ binding site [ion binding]; other site 525897011343 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 525897011344 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525897011345 nucleotide binding region [chemical binding]; other site 525897011346 ATP-binding site [chemical binding]; other site 525897011347 SEC-C motif; Region: SEC-C; pfam02810 525897011348 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 525897011349 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 525897011350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897011351 dimer interface [polypeptide binding]; other site 525897011352 conserved gate region; other site 525897011353 putative PBP binding loops; other site 525897011354 ABC-ATPase subunit interface; other site 525897011355 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 525897011356 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 525897011357 Walker A/P-loop; other site 525897011358 ATP binding site [chemical binding]; other site 525897011359 Q-loop/lid; other site 525897011360 ABC transporter signature motif; other site 525897011361 Walker B; other site 525897011362 D-loop; other site 525897011363 H-loop/switch region; other site 525897011364 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 525897011365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897011366 PAS domain; Region: PAS_9; pfam13426 525897011367 putative active site [active] 525897011368 heme pocket [chemical binding]; other site 525897011369 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525897011370 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525897011371 DNA binding residues [nucleotide binding] 525897011372 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897011373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897011374 active site 525897011375 phosphorylation site [posttranslational modification] 525897011376 intermolecular recognition site; other site 525897011377 dimerization interface [polypeptide binding]; other site 525897011378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897011379 Walker A motif; other site 525897011380 ATP binding site [chemical binding]; other site 525897011381 Walker B motif; other site 525897011382 arginine finger; other site 525897011383 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897011384 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525897011385 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897011386 putative active site [active] 525897011387 heme pocket [chemical binding]; other site 525897011388 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897011389 dimer interface [polypeptide binding]; other site 525897011390 phosphorylation site [posttranslational modification] 525897011391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897011392 ATP binding site [chemical binding]; other site 525897011393 Mg2+ binding site [ion binding]; other site 525897011394 G-X-G motif; other site 525897011395 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 525897011396 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 525897011397 active site 525897011398 NAD binding site [chemical binding]; other site 525897011399 metal binding site [ion binding]; metal-binding site 525897011400 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 525897011401 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 525897011402 dimer interface [polypeptide binding]; other site 525897011403 active site 525897011404 metal binding site [ion binding]; metal-binding site 525897011405 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 525897011406 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 525897011407 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 525897011408 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525897011409 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 525897011410 active site 525897011411 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 525897011412 active site 525897011413 homodimer interface [polypeptide binding]; other site 525897011414 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 525897011415 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 525897011416 putative acyl-acceptor binding pocket; other site 525897011417 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 525897011418 MarR family; Region: MarR; pfam01047 525897011419 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 525897011420 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 525897011421 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 525897011422 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322 525897011423 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 525897011424 active site 525897011425 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 525897011426 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 525897011427 active site 525897011428 FMN binding site [chemical binding]; other site 525897011429 substrate binding site [chemical binding]; other site 525897011430 putative catalytic residue [active] 525897011431 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 525897011432 G2 box; other site 525897011433 Switch I region; other site 525897011434 G3 box; other site 525897011435 Switch II region; other site 525897011436 PAS domain S-box; Region: sensory_box; TIGR00229 525897011437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897011438 putative active site [active] 525897011439 heme pocket [chemical binding]; other site 525897011440 PAS domain S-box; Region: sensory_box; TIGR00229 525897011441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897011442 putative active site [active] 525897011443 heme pocket [chemical binding]; other site 525897011444 Isochorismatase family; Region: Isochorismatase; pfam00857 525897011445 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 525897011446 conserved cis-peptide bond; other site 525897011447 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 525897011448 CoenzymeA binding site [chemical binding]; other site 525897011449 subunit interaction site [polypeptide binding]; other site 525897011450 PHB binding site; other site 525897011451 septum formation inhibitor; Reviewed; Region: minC; PRK00339 525897011452 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 525897011453 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 525897011454 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 525897011455 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 525897011456 Switch I; other site 525897011457 Switch II; other site 525897011458 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 525897011459 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 525897011460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525897011461 Coenzyme A binding pocket [chemical binding]; other site 525897011462 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 525897011463 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 525897011464 DNA binding site [nucleotide binding] 525897011465 catalytic residue [active] 525897011466 H2TH interface [polypeptide binding]; other site 525897011467 putative catalytic residues [active] 525897011468 turnover-facilitating residue; other site 525897011469 intercalation triad [nucleotide binding]; other site 525897011470 8OG recognition residue [nucleotide binding]; other site 525897011471 putative reading head residues; other site 525897011472 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 525897011473 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 525897011474 Protein of unknown function, DUF399; Region: DUF399; pfam04187 525897011475 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 525897011476 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 525897011477 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 525897011478 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525897011479 acyl-activating enzyme (AAE) consensus motif; other site 525897011480 AMP binding site [chemical binding]; other site 525897011481 active site 525897011482 CoA binding site [chemical binding]; other site 525897011483 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 525897011484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897011485 S-adenosylmethionine binding site [chemical binding]; other site 525897011486 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 525897011487 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 525897011488 homodimer interface [polypeptide binding]; other site 525897011489 oligonucleotide binding site [chemical binding]; other site 525897011490 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 525897011491 coproporphyrinogen III oxidase; Validated; Region: PRK05628 525897011492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897011493 FeS/SAM binding site; other site 525897011494 HemN C-terminal domain; Region: HemN_C; pfam06969 525897011495 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 525897011496 DEAD-like helicases superfamily; Region: DEXDc; smart00487 525897011497 ATP binding site [chemical binding]; other site 525897011498 Mg++ binding site [ion binding]; other site 525897011499 motif III; other site 525897011500 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525897011501 nucleotide binding region [chemical binding]; other site 525897011502 ATP-binding site [chemical binding]; other site 525897011503 PilZ domain; Region: PilZ; pfam07238 525897011504 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 525897011505 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 525897011506 DNA binding site [nucleotide binding] 525897011507 active site 525897011508 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 525897011509 rod shape-determining protein MreB; Provisional; Region: PRK13927 525897011510 MreB and similar proteins; Region: MreB_like; cd10225 525897011511 nucleotide binding site [chemical binding]; other site 525897011512 Mg binding site [ion binding]; other site 525897011513 putative protofilament interaction site [polypeptide binding]; other site 525897011514 RodZ interaction site [polypeptide binding]; other site 525897011515 rod shape-determining protein MreC; Provisional; Region: PRK13922 525897011516 rod shape-determining protein MreC; Region: MreC; pfam04085 525897011517 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 525897011518 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 525897011519 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 525897011520 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 525897011521 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 525897011522 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 525897011523 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 525897011524 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 525897011525 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 525897011526 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 525897011527 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 525897011528 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 525897011529 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 525897011530 beta subunit interaction interface [polypeptide binding]; other site 525897011531 Walker A motif; other site 525897011532 ATP binding site [chemical binding]; other site 525897011533 Walker B motif; other site 525897011534 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 525897011535 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 525897011536 core domain interface [polypeptide binding]; other site 525897011537 delta subunit interface [polypeptide binding]; other site 525897011538 epsilon subunit interface [polypeptide binding]; other site 525897011539 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 525897011540 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 525897011541 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 525897011542 alpha subunit interaction interface [polypeptide binding]; other site 525897011543 Walker A motif; other site 525897011544 ATP binding site [chemical binding]; other site 525897011545 Walker B motif; other site 525897011546 inhibitor binding site; inhibition site 525897011547 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 525897011548 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 525897011549 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 525897011550 gamma subunit interface [polypeptide binding]; other site 525897011551 epsilon subunit interface [polypeptide binding]; other site 525897011552 LBP interface [polypeptide binding]; other site 525897011553 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14356 525897011554 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 525897011555 Substrate binding site; other site 525897011556 Mg++ binding site; other site 525897011557 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 525897011558 active site 525897011559 substrate binding site [chemical binding]; other site 525897011560 CoA binding site [chemical binding]; other site 525897011561 Cell division protein ZapA; Region: ZapA; pfam05164 525897011562 phosphodiesterase; Provisional; Region: PRK12704 525897011563 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 525897011564 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525897011565 Zn2+ binding site [ion binding]; other site 525897011566 Mg2+ binding site [ion binding]; other site 525897011567 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 525897011568 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 525897011569 putative active site [active] 525897011570 metal binding site [ion binding]; metal-binding site 525897011571 homodimer binding site [polypeptide binding]; other site 525897011572 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 525897011573 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 525897011574 active site 525897011575 HIGH motif; other site 525897011576 dimer interface [polypeptide binding]; other site 525897011577 KMSKS motif; other site 525897011578 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525897011579 RNA binding surface [nucleotide binding]; other site 525897011580 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 525897011581 UbiA prenyltransferase family; Region: UbiA; pfam01040 525897011582 threonine synthase; Validated; Region: PRK06260 525897011583 TFIIH C1-like domain; Region: C1_4; cl06838 525897011584 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 525897011585 homodimer interface [polypeptide binding]; other site 525897011586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897011587 catalytic residue [active] 525897011588 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 525897011589 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 525897011590 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 525897011591 active site 525897011592 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 525897011593 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 525897011594 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 525897011595 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 525897011596 trimer interface [polypeptide binding]; other site 525897011597 active site 525897011598 UDP-GlcNAc binding site [chemical binding]; other site 525897011599 lipid binding site [chemical binding]; lipid-binding site 525897011600 periplasmic chaperone; Provisional; Region: PRK10780 525897011601 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 525897011602 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 525897011603 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 525897011604 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 525897011605 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 525897011606 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 525897011607 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 525897011608 Surface antigen; Region: Bac_surface_Ag; pfam01103 525897011609 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525897011610 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525897011611 Walker A/P-loop; other site 525897011612 ATP binding site [chemical binding]; other site 525897011613 Q-loop/lid; other site 525897011614 ABC transporter signature motif; other site 525897011615 Walker B; other site 525897011616 D-loop; other site 525897011617 H-loop/switch region; other site 525897011618 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 525897011619 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525897011620 FtsX-like permease family; Region: FtsX; pfam02687 525897011621 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 525897011622 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 525897011623 dimer interface [polypeptide binding]; other site 525897011624 putative anticodon binding site; other site 525897011625 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 525897011626 motif 1; other site 525897011627 active site 525897011628 motif 2; other site 525897011629 motif 3; other site 525897011630 active site 525897011631 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 525897011632 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 525897011633 active site 525897011634 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 525897011635 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 525897011636 homoserine dehydrogenase; Provisional; Region: PRK06349 525897011637 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 525897011638 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 525897011639 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 525897011640 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 525897011641 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525897011642 heme-binding residues [chemical binding]; other site 525897011643 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 525897011644 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525897011645 molybdopterin cofactor binding site; other site 525897011646 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 525897011647 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 525897011648 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897011649 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525897011650 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 525897011651 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 525897011652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525897011653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 525897011654 Radical SAM superfamily; Region: Radical_SAM; pfam04055 525897011655 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897011656 FeS/SAM binding site; other site 525897011657 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 525897011658 ATP cone domain; Region: ATP-cone; pfam03477 525897011659 Class III ribonucleotide reductase; Region: RNR_III; cd01675 525897011660 effector binding site; other site 525897011661 active site 525897011662 Zn binding site [ion binding]; other site 525897011663 glycine loop; other site 525897011664 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 525897011665 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 525897011666 PBP superfamily domain; Region: PBP_like_2; pfam12849 525897011667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525897011668 dimer interface [polypeptide binding]; other site 525897011669 conserved gate region; other site 525897011670 putative PBP binding loops; other site 525897011671 ABC-ATPase subunit interface; other site 525897011672 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525897011673 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 525897011674 Walker A/P-loop; other site 525897011675 ATP binding site [chemical binding]; other site 525897011676 Q-loop/lid; other site 525897011677 ABC transporter signature motif; other site 525897011678 Walker B; other site 525897011679 D-loop; other site 525897011680 H-loop/switch region; other site 525897011681 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 525897011682 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 525897011683 putative dimer interface [polypeptide binding]; other site 525897011684 AAA domain; Region: AAA_32; pfam13654 525897011685 Protein of unknown function (DUF972); Region: DUF972; pfam06156 525897011686 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 525897011687 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 525897011688 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 525897011689 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525897011690 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 525897011691 FeS/SAM binding site; other site 525897011692 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 525897011693 active site 525897011694 catalytic residues [active] 525897011695 DNA binding site [nucleotide binding] 525897011696 Int/Topo IB signature motif; other site 525897011697 molybdenum-pterin binding domain; Region: Mop; TIGR00638 525897011698 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 525897011699 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897011700 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897011701 metal binding site [ion binding]; metal-binding site 525897011702 active site 525897011703 I-site; other site 525897011704 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897011705 metal binding site [ion binding]; metal-binding site 525897011706 active site 525897011707 I-site; other site 525897011708 TPR repeat; Region: TPR_11; pfam13414 525897011709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897011710 TPR motif; other site 525897011711 TPR repeat; Region: TPR_11; pfam13414 525897011712 binding surface 525897011713 TPR repeat; Region: TPR_11; pfam13414 525897011714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525897011715 TPR motif; other site 525897011716 binding surface 525897011717 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 525897011718 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 525897011719 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 525897011720 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 525897011721 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525897011722 active site 525897011723 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525897011724 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 525897011725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897011726 putative active site [active] 525897011727 heme pocket [chemical binding]; other site 525897011728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897011729 dimer interface [polypeptide binding]; other site 525897011730 phosphorylation site [posttranslational modification] 525897011731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897011732 ATP binding site [chemical binding]; other site 525897011733 Mg2+ binding site [ion binding]; other site 525897011734 G-X-G motif; other site 525897011735 Response regulator receiver domain; Region: Response_reg; pfam00072 525897011736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897011737 active site 525897011738 phosphorylation site [posttranslational modification] 525897011739 intermolecular recognition site; other site 525897011740 dimerization interface [polypeptide binding]; other site 525897011741 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 525897011742 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 525897011743 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 525897011744 GTPase CgtA; Reviewed; Region: obgE; PRK12299 525897011745 GTP1/OBG; Region: GTP1_OBG; pfam01018 525897011746 Obg GTPase; Region: Obg; cd01898 525897011747 G1 box; other site 525897011748 GTP/Mg2+ binding site [chemical binding]; other site 525897011749 Switch I region; other site 525897011750 G2 box; other site 525897011751 G3 box; other site 525897011752 Switch II region; other site 525897011753 G4 box; other site 525897011754 G5 box; other site 525897011755 gamma-glutamyl kinase; Provisional; Region: PRK05429 525897011756 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 525897011757 nucleotide binding site [chemical binding]; other site 525897011758 homotetrameric interface [polypeptide binding]; other site 525897011759 putative phosphate binding site [ion binding]; other site 525897011760 putative allosteric binding site; other site 525897011761 PUA domain; Region: PUA; pfam01472 525897011762 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 525897011763 Thiamine pyrophosphokinase; Region: TPK; cd07995 525897011764 active site 525897011765 dimerization interface [polypeptide binding]; other site 525897011766 thiamine binding site [chemical binding]; other site 525897011767 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 525897011768 proline aminopeptidase P II; Provisional; Region: PRK10879 525897011769 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 525897011770 active site 525897011771 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 525897011772 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 525897011773 active site 525897011774 dimer interface [polypeptide binding]; other site 525897011775 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 525897011776 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 525897011777 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 525897011778 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 525897011779 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 525897011780 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 525897011781 PilX N-terminal; Region: PilX_N; pfam14341 525897011782 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 525897011783 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525897011784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897011785 active site 525897011786 phosphorylation site [posttranslational modification] 525897011787 intermolecular recognition site; other site 525897011788 dimerization interface [polypeptide binding]; other site 525897011789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897011790 Walker A motif; other site 525897011791 ATP binding site [chemical binding]; other site 525897011792 Walker B motif; other site 525897011793 arginine finger; other site 525897011794 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525897011795 Type III secretion chaperone domain; Region: Chaperone_III; cl06729 525897011796 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 525897011797 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 525897011798 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 525897011799 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 525897011800 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 525897011801 CoA binding domain; Region: CoA_binding_2; pfam13380 525897011802 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 525897011803 glutamate dehydrogenase; Provisional; Region: PRK09414 525897011804 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 525897011805 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 525897011806 NAD(P) binding site [chemical binding]; other site 525897011807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 525897011808 active site 525897011809 phosphorylation site [posttranslational modification] 525897011810 intermolecular recognition site; other site 525897011811 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 525897011812 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 525897011813 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 525897011814 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 525897011815 dimerization interface [polypeptide binding]; other site 525897011816 Lysine efflux permease [General function prediction only]; Region: COG1279 525897011817 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 525897011818 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 525897011819 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 525897011820 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525897011821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525897011822 homodimer interface [polypeptide binding]; other site 525897011823 catalytic residue [active] 525897011824 cobyric acid synthase; Provisional; Region: PRK00784 525897011825 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525897011826 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525897011827 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 525897011828 catalytic triad [active] 525897011829 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 525897011830 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525897011831 molybdopterin cofactor binding site; other site 525897011832 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 525897011833 molybdopterin cofactor binding site; other site 525897011834 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 525897011835 active site 525897011836 HIGH motif; other site 525897011837 nucleotide binding site [chemical binding]; other site 525897011838 active site 525897011839 KMSKS motif; other site 525897011840 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 525897011841 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 525897011842 putative active site [active] 525897011843 metal binding site [ion binding]; metal-binding site 525897011844 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 525897011845 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 525897011846 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 525897011847 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 525897011848 Aspartase; Region: Aspartase; cd01357 525897011849 active sites [active] 525897011850 tetramer interface [polypeptide binding]; other site 525897011851 Transcriptional regulator [Transcription]; Region: LysR; COG0583 525897011852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 525897011853 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 525897011854 dimerization interface [polypeptide binding]; other site 525897011855 putative transporter; Provisional; Region: PRK11021 525897011856 Rubrerythrin [Energy production and conversion]; Region: COG1592 525897011857 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 525897011858 binuclear metal center [ion binding]; other site 525897011859 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 525897011860 iron binding site [ion binding]; other site 525897011861 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 525897011862 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 525897011863 putative dimer interface [polypeptide binding]; other site 525897011864 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 525897011865 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 525897011866 putative dimer interface [polypeptide binding]; other site 525897011867 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 525897011868 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 525897011869 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 525897011870 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 525897011871 FMN binding site [chemical binding]; other site 525897011872 active site 525897011873 catalytic residues [active] 525897011874 substrate binding site [chemical binding]; other site 525897011875 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 525897011876 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 525897011877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897011878 active site 525897011879 phosphorylation site [posttranslational modification] 525897011880 intermolecular recognition site; other site 525897011881 dimerization interface [polypeptide binding]; other site 525897011882 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 525897011883 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 525897011884 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 525897011885 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 525897011886 DNA binding residues [nucleotide binding] 525897011887 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 525897011888 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 525897011889 P-loop; other site 525897011890 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 525897011891 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 525897011892 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 525897011893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897011894 Walker A motif; other site 525897011895 ATP binding site [chemical binding]; other site 525897011896 Walker B motif; other site 525897011897 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 525897011898 FHIPEP family; Region: FHIPEP; pfam00771 525897011899 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 525897011900 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 525897011901 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 525897011902 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 525897011903 Ligand Binding Site [chemical binding]; other site 525897011904 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 525897011905 chaperone protein DnaJ; Provisional; Region: PRK14301 525897011906 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 525897011907 HSP70 interaction site [polypeptide binding]; other site 525897011908 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 525897011909 Zn binding sites [ion binding]; other site 525897011910 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 525897011911 dimer interface [polypeptide binding]; other site 525897011912 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 525897011913 trimer interface [polypeptide binding]; other site 525897011914 dimer interface [polypeptide binding]; other site 525897011915 putative active site [active] 525897011916 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 525897011917 Cache domain; Region: Cache_1; pfam02743 525897011918 PAS domain S-box; Region: sensory_box; TIGR00229 525897011919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525897011920 putative active site [active] 525897011921 heme pocket [chemical binding]; other site 525897011922 PAS fold; Region: PAS_3; pfam08447 525897011923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525897011924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525897011925 dimer interface [polypeptide binding]; other site 525897011926 phosphorylation site [posttranslational modification] 525897011927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525897011928 ATP binding site [chemical binding]; other site 525897011929 Mg2+ binding site [ion binding]; other site 525897011930 G-X-G motif; other site 525897011931 Response regulator receiver domain; Region: Response_reg; pfam00072 525897011932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525897011933 active site 525897011934 phosphorylation site [posttranslational modification] 525897011935 intermolecular recognition site; other site 525897011936 dimerization interface [polypeptide binding]; other site 525897011937 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 525897011938 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 525897011939 substrate binding site [chemical binding]; other site 525897011940 glutamase interaction surface [polypeptide binding]; other site 525897011941 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 525897011942 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 525897011943 putative active site [active] 525897011944 oxyanion strand; other site 525897011945 catalytic triad [active] 525897011946 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 525897011947 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 525897011948 NADP binding site [chemical binding]; other site 525897011949 homopentamer interface [polypeptide binding]; other site 525897011950 substrate binding site [chemical binding]; other site 525897011951 active site 525897011952 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 525897011953 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 525897011954 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 525897011955 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 525897011956 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 525897011957 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 525897011958 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 525897011959 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525897011960 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525897011961 metal binding site [ion binding]; metal-binding site 525897011962 active site 525897011963 I-site; other site 525897011964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 525897011965 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 525897011966 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 525897011967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525897011968 S-adenosylmethionine binding site [chemical binding]; other site 525897011969 hypothetical protein; Validated; Region: PRK00110 525897011970 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 525897011971 active site 525897011972 putative DNA-binding cleft [nucleotide binding]; other site 525897011973 dimer interface [polypeptide binding]; other site 525897011974 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14602 525897011975 RuvA N terminal domain; Region: RuvA_N; pfam01330 525897011976 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 525897011977 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 525897011978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525897011979 Walker A motif; other site 525897011980 ATP binding site [chemical binding]; other site 525897011981 Walker B motif; other site 525897011982 arginine finger; other site 525897011983 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 525897011984 Thymidylate synthase complementing protein; Region: Thy1; pfam02511