-- dump date 20140619_063215 -- class Genbank::misc_feature -- table misc_feature_note -- id note 706587000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 706587000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 706587000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587000004 Walker A motif; other site 706587000005 ATP binding site [chemical binding]; other site 706587000006 Walker B motif; other site 706587000007 arginine finger; other site 706587000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 706587000009 DnaA box-binding interface [nucleotide binding]; other site 706587000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 706587000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 706587000012 putative DNA binding surface [nucleotide binding]; other site 706587000013 dimer interface [polypeptide binding]; other site 706587000014 beta-clamp/clamp loader binding surface; other site 706587000015 beta-clamp/translesion DNA polymerase binding surface; other site 706587000016 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 706587000017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587000018 Mg2+ binding site [ion binding]; other site 706587000019 G-X-G motif; other site 706587000020 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 706587000021 anchoring element; other site 706587000022 dimer interface [polypeptide binding]; other site 706587000023 ATP binding site [chemical binding]; other site 706587000024 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 706587000025 active site 706587000026 putative metal-binding site [ion binding]; other site 706587000027 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 706587000028 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 706587000029 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 706587000030 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 706587000031 Walker A motif; other site 706587000032 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 706587000033 Cysteine-rich domain; Region: CCG; pfam02754 706587000034 Cysteine-rich domain; Region: CCG; pfam02754 706587000035 CoB--CoM heterodisulfide reductase, subunit C; Region: CoB_CoM_SS_C; TIGR03290 706587000036 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 706587000037 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587000038 4Fe-4S binding domain; Region: Fer4; pfam00037 706587000039 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 706587000040 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 706587000041 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 706587000042 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 706587000043 TPP-binding site [chemical binding]; other site 706587000044 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 706587000045 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 706587000046 dimer interface [polypeptide binding]; other site 706587000047 PYR/PP interface [polypeptide binding]; other site 706587000048 TPP binding site [chemical binding]; other site 706587000049 substrate binding site [chemical binding]; other site 706587000050 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706587000051 Ferredoxin [Energy production and conversion]; Region: COG1146 706587000052 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587000053 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 706587000054 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 706587000055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587000056 Walker A motif; other site 706587000057 ATP binding site [chemical binding]; other site 706587000058 Walker B motif; other site 706587000059 arginine finger; other site 706587000060 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 706587000061 metal ion-dependent adhesion site (MIDAS); other site 706587000062 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 706587000063 Uncharacterized conserved protein [Function unknown]; Region: COG1434 706587000064 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 706587000065 putative active site [active] 706587000066 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 706587000067 active site 706587000068 cosubstrate binding site; other site 706587000069 substrate binding site [chemical binding]; other site 706587000070 catalytic site [active] 706587000071 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587000072 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 706587000073 putative ADP-binding pocket [chemical binding]; other site 706587000074 putative glycosyl transferase; Provisional; Region: PRK10307 706587000075 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 706587000076 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706587000077 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 706587000078 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 706587000079 putative active site [active] 706587000080 Caenorhabditis protein of unknown function, DUF268; Region: DUF268; pfam03269 706587000081 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706587000082 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 706587000083 Methyltransferase domain; Region: Methyltransf_23; pfam13489 706587000084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587000085 S-adenosylmethionine binding site [chemical binding]; other site 706587000086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 706587000087 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 706587000088 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 706587000089 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 706587000090 Bacterial sugar transferase; Region: Bac_transf; pfam02397 706587000091 CoA-binding domain; Region: CoA_binding_3; pfam13727 706587000092 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 706587000093 FAD binding domain; Region: FAD_binding_4; pfam01565 706587000094 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 706587000095 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587000096 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587000097 Cysteine-rich domain; Region: CCG; pfam02754 706587000098 Cysteine-rich domain; Region: CCG; pfam02754 706587000099 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 706587000100 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 706587000101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587000102 S-adenosylmethionine binding site [chemical binding]; other site 706587000103 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587000104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587000105 TPR motif; other site 706587000106 binding surface 706587000107 TPR repeat; Region: TPR_11; pfam13414 706587000108 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 706587000109 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 706587000110 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 706587000111 putative binding surface; other site 706587000112 active site 706587000113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587000114 ATP binding site [chemical binding]; other site 706587000115 Mg2+ binding site [ion binding]; other site 706587000116 G-X-G motif; other site 706587000117 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 706587000118 Response regulator receiver domain; Region: Response_reg; pfam00072 706587000119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587000120 active site 706587000121 phosphorylation site [posttranslational modification] 706587000122 intermolecular recognition site; other site 706587000123 dimerization interface [polypeptide binding]; other site 706587000124 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 706587000125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587000126 active site 706587000127 phosphorylation site [posttranslational modification] 706587000128 intermolecular recognition site; other site 706587000129 dimerization interface [polypeptide binding]; other site 706587000130 CheB methylesterase; Region: CheB_methylest; pfam01339 706587000131 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587000132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587000133 active site 706587000134 phosphorylation site [posttranslational modification] 706587000135 intermolecular recognition site; other site 706587000136 dimerization interface [polypeptide binding]; other site 706587000137 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000138 PAS fold; Region: PAS_3; pfam08447 706587000139 putative active site [active] 706587000140 heme pocket [chemical binding]; other site 706587000141 Response regulator receiver domain; Region: Response_reg; pfam00072 706587000142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587000143 active site 706587000144 phosphorylation site [posttranslational modification] 706587000145 intermolecular recognition site; other site 706587000146 dimerization interface [polypeptide binding]; other site 706587000147 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 706587000148 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 706587000149 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 706587000150 G1 box; other site 706587000151 GTP/Mg2+ binding site [chemical binding]; other site 706587000152 G2 box; other site 706587000153 Switch I region; other site 706587000154 G3 box; other site 706587000155 Switch II region; other site 706587000156 G4 box; other site 706587000157 G5 box; other site 706587000158 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587000159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000160 putative active site [active] 706587000161 heme pocket [chemical binding]; other site 706587000162 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587000163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000164 putative active site [active] 706587000165 heme pocket [chemical binding]; other site 706587000166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587000167 ATP binding site [chemical binding]; other site 706587000168 Mg2+ binding site [ion binding]; other site 706587000169 G-X-G motif; other site 706587000170 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587000171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587000172 active site 706587000173 phosphorylation site [posttranslational modification] 706587000174 intermolecular recognition site; other site 706587000175 dimerization interface [polypeptide binding]; other site 706587000176 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 706587000177 PRC-barrel domain; Region: PRC; pfam05239 706587000178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587000179 phosphorylation site [posttranslational modification] 706587000180 dimer interface [polypeptide binding]; other site 706587000181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587000182 ATP binding site [chemical binding]; other site 706587000183 Mg2+ binding site [ion binding]; other site 706587000184 G-X-G motif; other site 706587000185 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 706587000186 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 706587000187 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 706587000188 putative valine binding site [chemical binding]; other site 706587000189 dimer interface [polypeptide binding]; other site 706587000190 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 706587000191 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 706587000192 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 706587000193 PYR/PP interface [polypeptide binding]; other site 706587000194 dimer interface [polypeptide binding]; other site 706587000195 TPP binding site [chemical binding]; other site 706587000196 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 706587000197 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 706587000198 TPP-binding site [chemical binding]; other site 706587000199 dimer interface [polypeptide binding]; other site 706587000200 Preprotein translocase SecG subunit; Region: SecG; pfam03840 706587000201 triosephosphate isomerase; Provisional; Region: PRK14565 706587000202 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 706587000203 substrate binding site [chemical binding]; other site 706587000204 dimer interface [polypeptide binding]; other site 706587000205 catalytic triad [active] 706587000206 Phosphoglycerate kinase; Region: PGK; pfam00162 706587000207 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 706587000208 substrate binding site [chemical binding]; other site 706587000209 hinge regions; other site 706587000210 ADP binding site [chemical binding]; other site 706587000211 catalytic site [active] 706587000212 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 706587000213 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 706587000214 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 706587000215 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 706587000216 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 706587000217 dimer interface [polypeptide binding]; other site 706587000218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587000219 catalytic residue [active] 706587000220 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 706587000221 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587000222 acyl-activating enzyme (AAE) consensus motif; other site 706587000223 AMP binding site [chemical binding]; other site 706587000224 active site 706587000225 CoA binding site [chemical binding]; other site 706587000226 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 706587000227 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 706587000228 ATP-grasp domain; Region: ATP-grasp_4; cl17255 706587000229 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 706587000230 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 706587000231 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 706587000232 ATP-grasp domain; Region: ATP-grasp_4; cl17255 706587000233 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 706587000234 IMP binding site; other site 706587000235 dimer interface [polypeptide binding]; other site 706587000236 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 706587000237 Amidohydrolase; Region: Amidohydro_2; pfam04909 706587000238 Helix-turn-helix domain; Region: HTH_17; pfam12728 706587000239 PBP superfamily domain; Region: PBP_like; pfam12727 706587000240 PBP superfamily domain; Region: PBP_like_2; pfam12849 706587000241 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 706587000242 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 706587000243 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 706587000244 dimerization interface [polypeptide binding]; other site 706587000245 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 706587000246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587000247 dimer interface [polypeptide binding]; other site 706587000248 conserved gate region; other site 706587000249 putative PBP binding loops; other site 706587000250 ABC-ATPase subunit interface; other site 706587000251 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 706587000252 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 706587000253 Walker A/P-loop; other site 706587000254 ATP binding site [chemical binding]; other site 706587000255 Q-loop/lid; other site 706587000256 ABC transporter signature motif; other site 706587000257 Walker B; other site 706587000258 D-loop; other site 706587000259 H-loop/switch region; other site 706587000260 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 706587000261 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587000262 substrate binding site [chemical binding]; other site 706587000263 oxyanion hole (OAH) forming residues; other site 706587000264 trimer interface [polypeptide binding]; other site 706587000265 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 706587000266 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 706587000267 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 706587000268 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 706587000269 protein binding site [polypeptide binding]; other site 706587000270 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 706587000271 Catalytic dyad [active] 706587000272 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 706587000273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587000274 FeS/SAM binding site; other site 706587000275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 706587000276 TPR motif; other site 706587000277 binding surface 706587000278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587000279 TPR motif; other site 706587000280 binding surface 706587000281 Catalytic domain of Protein Kinases; Region: PKc; cd00180 706587000282 active site 706587000283 substrate binding site [chemical binding]; other site 706587000284 ATP binding site [chemical binding]; other site 706587000285 Protein kinase domain; Region: Pkinase; pfam00069 706587000286 activation loop (A-loop); other site 706587000287 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 706587000288 Peptidase family M23; Region: Peptidase_M23; pfam01551 706587000289 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 706587000290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587000291 TPR motif; other site 706587000292 binding surface 706587000293 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 706587000294 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 706587000295 ligand binding site [chemical binding]; other site 706587000296 TolB amino-terminal domain; Region: TolB_N; pfam04052 706587000297 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 706587000298 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 706587000299 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 706587000300 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 706587000301 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 706587000302 TolA protein; Region: tolA_full; TIGR02794 706587000303 TonB C terminal; Region: TonB_2; pfam13103 706587000304 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 706587000305 TolR protein; Region: tolR; TIGR02801 706587000306 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 706587000307 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587000308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587000309 active site 706587000310 phosphorylation site [posttranslational modification] 706587000311 intermolecular recognition site; other site 706587000312 dimerization interface [polypeptide binding]; other site 706587000313 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 706587000314 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706587000315 ATP binding site [chemical binding]; other site 706587000316 putative Mg++ binding site [ion binding]; other site 706587000317 helicase superfamily c-terminal domain; Region: HELICc; smart00490 706587000318 nucleotide binding region [chemical binding]; other site 706587000319 ATP-binding site [chemical binding]; other site 706587000320 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 706587000321 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 706587000322 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 706587000323 dihydropteroate synthase; Region: DHPS; TIGR01496 706587000324 substrate binding pocket [chemical binding]; other site 706587000325 dimer interface [polypeptide binding]; other site 706587000326 inhibitor binding site; inhibition site 706587000327 FtsH Extracellular; Region: FtsH_ext; pfam06480 706587000328 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 706587000329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587000330 Walker A motif; other site 706587000331 ATP binding site [chemical binding]; other site 706587000332 Walker B motif; other site 706587000333 arginine finger; other site 706587000334 Peptidase family M41; Region: Peptidase_M41; pfam01434 706587000335 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 706587000336 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 706587000337 NAD(P) binding site [chemical binding]; other site 706587000338 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 706587000339 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 706587000340 RNA binding surface [nucleotide binding]; other site 706587000341 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 706587000342 active site 706587000343 Dodecin; Region: Dodecin; pfam07311 706587000344 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 706587000345 DNA repair protein RadA; Provisional; Region: PRK11823 706587000346 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 706587000347 Walker A motif; other site 706587000348 ATP binding site [chemical binding]; other site 706587000349 Walker B motif; other site 706587000350 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 706587000351 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 706587000352 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 706587000353 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 706587000354 RNA/DNA hybrid binding site [nucleotide binding]; other site 706587000355 active site 706587000356 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 706587000357 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 706587000358 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 706587000359 dimer interface [polypeptide binding]; other site 706587000360 active site 706587000361 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 706587000362 Sel1-like repeats; Region: SEL1; smart00671 706587000363 Sel1-like repeats; Region: SEL1; smart00671 706587000364 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 706587000365 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587000366 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587000367 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587000368 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587000369 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587000370 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 706587000371 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587000372 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587000373 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587000374 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587000375 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587000376 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587000377 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587000378 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587000379 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587000380 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587000381 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587000382 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587000383 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587000384 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587000385 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587000386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587000387 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587000388 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 706587000389 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587000390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587000391 phosphorylation site [posttranslational modification] 706587000392 PilZ domain; Region: PilZ; pfam07238 706587000393 Cache domain; Region: Cache_1; pfam02743 706587000394 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587000395 dimerization interface [polypeptide binding]; other site 706587000396 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706587000397 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706587000398 dimer interface [polypeptide binding]; other site 706587000399 putative CheW interface [polypeptide binding]; other site 706587000400 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 706587000401 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706587000402 ligand binding site [chemical binding]; other site 706587000403 flexible hinge region; other site 706587000404 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587000405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 706587000406 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 706587000407 4Fe-4S binding domain; Region: Fer4_5; pfam12801 706587000408 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 706587000409 MG2 domain; Region: A2M_N; pfam01835 706587000410 Alpha-2-macroglobulin family; Region: A2M; pfam00207 706587000411 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 706587000412 surface patch; other site 706587000413 thioester region; other site 706587000414 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587000415 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587000416 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587000417 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587000418 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587000419 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 706587000420 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 706587000421 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587000422 Zn2+ binding site [ion binding]; other site 706587000423 Mg2+ binding site [ion binding]; other site 706587000424 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 706587000425 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 706587000426 dimer interface [polypeptide binding]; other site 706587000427 decamer (pentamer of dimers) interface [polypeptide binding]; other site 706587000428 catalytic triad [active] 706587000429 peroxidatic and resolving cysteines [active] 706587000430 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 706587000431 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 706587000432 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 706587000433 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 706587000434 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 706587000435 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 706587000436 N-acetyl-D-glucosamine binding site [chemical binding]; other site 706587000437 catalytic residue [active] 706587000438 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 706587000439 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 706587000440 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 706587000441 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 706587000442 active site 706587000443 DNA binding site [nucleotide binding] 706587000444 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 706587000445 DNA binding site [nucleotide binding] 706587000446 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 706587000447 nucleotide binding site [chemical binding]; other site 706587000448 primosome assembly protein PriA; Validated; Region: PRK05580 706587000449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706587000450 ATP binding site [chemical binding]; other site 706587000451 putative Mg++ binding site [ion binding]; other site 706587000452 helicase superfamily c-terminal domain; Region: HELICc; smart00490 706587000453 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 706587000454 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 706587000455 catalytic residues [active] 706587000456 PII uridylyl-transferase; Provisional; Region: PRK05092 706587000457 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 706587000458 metal binding triad; other site 706587000459 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 706587000460 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 706587000461 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 706587000462 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 706587000463 Uncharacterized conserved protein [Function unknown]; Region: COG1656 706587000464 Protein of unknown function DUF82; Region: DUF82; pfam01927 706587000465 EamA-like transporter family; Region: EamA; cl17759 706587000466 EamA-like transporter family; Region: EamA; cl17759 706587000467 PAS domain S-box; Region: sensory_box; TIGR00229 706587000468 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000469 putative active site [active] 706587000470 heme pocket [chemical binding]; other site 706587000471 PAS domain S-box; Region: sensory_box; TIGR00229 706587000472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000473 putative active site [active] 706587000474 heme pocket [chemical binding]; other site 706587000475 PAS fold; Region: PAS_3; pfam08447 706587000476 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000477 PAS fold; Region: PAS_3; pfam08447 706587000478 putative active site [active] 706587000479 heme pocket [chemical binding]; other site 706587000480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587000481 dimer interface [polypeptide binding]; other site 706587000482 phosphorylation site [posttranslational modification] 706587000483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587000484 ATP binding site [chemical binding]; other site 706587000485 Mg2+ binding site [ion binding]; other site 706587000486 G-X-G motif; other site 706587000487 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 706587000488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706587000489 NAD(P) binding site [chemical binding]; other site 706587000490 active site 706587000491 TIGR03032 family protein; Region: TIGR03032 706587000492 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 706587000493 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 706587000494 Ligand binding site; other site 706587000495 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 706587000496 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 706587000497 PYR/PP interface [polypeptide binding]; other site 706587000498 dimer interface [polypeptide binding]; other site 706587000499 TPP binding site [chemical binding]; other site 706587000500 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706587000501 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 706587000502 TPP-binding site [chemical binding]; other site 706587000503 dimer interface [polypeptide binding]; other site 706587000504 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 706587000505 AAA domain; Region: AAA_33; pfam13671 706587000506 ligand-binding site [chemical binding]; other site 706587000507 Uncharacterized conserved protein [Function unknown]; Region: COG3379 706587000508 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 706587000509 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 706587000510 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 706587000511 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 706587000512 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 706587000513 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 706587000514 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 706587000515 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 706587000516 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 706587000517 Transglycosylase; Region: Transgly; pfam00912 706587000518 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 706587000519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 706587000520 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 706587000521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 706587000522 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 706587000523 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587000524 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587000525 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587000526 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587000527 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587000528 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000529 putative active site [active] 706587000530 heme pocket [chemical binding]; other site 706587000531 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587000532 dimer interface [polypeptide binding]; other site 706587000533 phosphorylation site [posttranslational modification] 706587000534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587000535 ATP binding site [chemical binding]; other site 706587000536 Mg2+ binding site [ion binding]; other site 706587000537 G-X-G motif; other site 706587000538 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 706587000539 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 706587000540 active site 706587000541 metal binding site [ion binding]; metal-binding site 706587000542 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 706587000543 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706587000544 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 706587000545 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 706587000546 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 706587000547 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 706587000548 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 706587000549 4Fe-4S binding domain; Region: Fer4_6; pfam12837 706587000550 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 706587000551 4Fe-4S binding domain; Region: Fer4; pfam00037 706587000552 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587000553 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 706587000554 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 706587000555 Cysteine-rich domain; Region: CCG; pfam02754 706587000556 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 706587000557 Cysteine-rich domain; Region: CCG; pfam02754 706587000558 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 706587000559 lipoyl attachment site [posttranslational modification]; other site 706587000560 peptide-modifying radical SAM enzyme CbpB; Region: rSAM_cobopep; TIGR04163 706587000561 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587000562 FeS/SAM binding site; other site 706587000563 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 706587000564 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 706587000565 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 706587000566 active site 706587000567 multimer interface [polypeptide binding]; other site 706587000568 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 706587000569 predicted active site [active] 706587000570 catalytic triad [active] 706587000571 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 706587000572 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 706587000573 dimerization interface 3.5A [polypeptide binding]; other site 706587000574 active site 706587000575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587000576 FeS/SAM binding site; other site 706587000577 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 706587000578 CoenzymeA binding site [chemical binding]; other site 706587000579 subunit interaction site [polypeptide binding]; other site 706587000580 PHB binding site; other site 706587000581 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 706587000582 AAA domain; Region: AAA_33; pfam13671 706587000583 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 706587000584 Uncharacterized conserved protein [Function unknown]; Region: COG2006 706587000585 Domain of unknown function (DUF362); Region: DUF362; pfam04015 706587000586 4Fe-4S binding domain; Region: Fer4; pfam00037 706587000587 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 706587000588 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 706587000589 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 706587000590 heme binding site [chemical binding]; other site 706587000591 ferroxidase pore; other site 706587000592 ferroxidase diiron center [ion binding]; other site 706587000593 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 706587000594 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 706587000595 dimer interface [polypeptide binding]; other site 706587000596 active site 706587000597 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 706587000598 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 706587000599 Chromate transporter; Region: Chromate_transp; pfam02417 706587000600 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 706587000601 active site residue [active] 706587000602 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 706587000603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587000604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706587000605 putative substrate translocation pore; other site 706587000606 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 706587000607 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 706587000608 Walker A/P-loop; other site 706587000609 ATP binding site [chemical binding]; other site 706587000610 Q-loop/lid; other site 706587000611 ABC transporter signature motif; other site 706587000612 Walker B; other site 706587000613 D-loop; other site 706587000614 H-loop/switch region; other site 706587000615 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 706587000616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587000617 dimer interface [polypeptide binding]; other site 706587000618 conserved gate region; other site 706587000619 putative PBP binding loops; other site 706587000620 ABC-ATPase subunit interface; other site 706587000621 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 706587000622 NMT1-like family; Region: NMT1_2; pfam13379 706587000623 cyanate hydratase; Validated; Region: PRK02866 706587000624 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 706587000625 oligomer interface [polypeptide binding]; other site 706587000626 active site 706587000627 PAS domain S-box; Region: sensory_box; TIGR00229 706587000628 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000629 putative active site [active] 706587000630 heme pocket [chemical binding]; other site 706587000631 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587000632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000633 putative active site [active] 706587000634 heme pocket [chemical binding]; other site 706587000635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587000636 dimer interface [polypeptide binding]; other site 706587000637 phosphorylation site [posttranslational modification] 706587000638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587000639 ATP binding site [chemical binding]; other site 706587000640 Mg2+ binding site [ion binding]; other site 706587000641 G-X-G motif; other site 706587000642 Heavy-metal-associated domain; Region: HMA; pfam00403 706587000643 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 706587000644 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 706587000645 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 706587000646 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 706587000647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706587000648 motif II; other site 706587000649 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 706587000650 S-adenosylmethionine synthetase; Validated; Region: PRK05250 706587000651 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 706587000652 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 706587000653 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 706587000654 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 706587000655 PAS domain S-box; Region: sensory_box; TIGR00229 706587000656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000657 putative active site [active] 706587000658 heme pocket [chemical binding]; other site 706587000659 GAF domain; Region: GAF_2; pfam13185 706587000660 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 706587000661 PAS domain S-box; Region: sensory_box; TIGR00229 706587000662 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000663 putative active site [active] 706587000664 heme pocket [chemical binding]; other site 706587000665 PAS domain S-box; Region: sensory_box; TIGR00229 706587000666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587000667 dimer interface [polypeptide binding]; other site 706587000668 phosphorylation site [posttranslational modification] 706587000669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587000670 ATP binding site [chemical binding]; other site 706587000671 Mg2+ binding site [ion binding]; other site 706587000672 G-X-G motif; other site 706587000673 Response regulator receiver domain; Region: Response_reg; pfam00072 706587000674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587000675 active site 706587000676 phosphorylation site [posttranslational modification] 706587000677 intermolecular recognition site; other site 706587000678 dimerization interface [polypeptide binding]; other site 706587000679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587000680 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706587000681 putative substrate translocation pore; other site 706587000682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 706587000683 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 706587000684 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 706587000685 Sensory domain found in PocR; Region: PocR; pfam10114 706587000686 PAS domain; Region: PAS_9; pfam13426 706587000687 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000688 putative active site [active] 706587000689 heme pocket [chemical binding]; other site 706587000690 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706587000691 GAF domain; Region: GAF; cl17456 706587000692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000693 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 706587000694 putative active site [active] 706587000695 heme pocket [chemical binding]; other site 706587000696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000697 putative active site [active] 706587000698 heme pocket [chemical binding]; other site 706587000699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587000700 Walker A motif; other site 706587000701 ATP binding site [chemical binding]; other site 706587000702 Walker B motif; other site 706587000703 arginine finger; other site 706587000704 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587000705 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 706587000706 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 706587000707 putative homodimer interface [polypeptide binding]; other site 706587000708 putative homotetramer interface [polypeptide binding]; other site 706587000709 putative allosteric switch controlling residues; other site 706587000710 putative metal binding site [ion binding]; other site 706587000711 putative homodimer-homodimer interface [polypeptide binding]; other site 706587000712 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 706587000713 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 706587000714 Soluble P-type ATPase [General function prediction only]; Region: COG4087 706587000715 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 706587000716 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 706587000717 putative NAD(P) binding site [chemical binding]; other site 706587000718 putative substrate binding site [chemical binding]; other site 706587000719 catalytic Zn binding site [ion binding]; other site 706587000720 structural Zn binding site [ion binding]; other site 706587000721 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 706587000722 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 706587000723 active site 706587000724 acyl-activating enzyme (AAE) consensus motif; other site 706587000725 putative CoA binding site [chemical binding]; other site 706587000726 AMP binding site [chemical binding]; other site 706587000727 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 706587000728 Found in ATP-dependent protease La (LON); Region: LON; smart00464 706587000729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587000730 Walker A motif; other site 706587000731 ATP binding site [chemical binding]; other site 706587000732 Walker B motif; other site 706587000733 arginine finger; other site 706587000734 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 706587000735 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 706587000736 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 706587000737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587000738 Walker A motif; other site 706587000739 ATP binding site [chemical binding]; other site 706587000740 Walker B motif; other site 706587000741 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 706587000742 Clp protease; Region: CLP_protease; pfam00574 706587000743 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 706587000744 oligomer interface [polypeptide binding]; other site 706587000745 active site residues [active] 706587000746 trigger factor; Provisional; Region: tig; PRK01490 706587000747 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 706587000748 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 706587000749 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 706587000750 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 706587000751 Ligand binding site; other site 706587000752 Putative Catalytic site; other site 706587000753 DXD motif; other site 706587000754 Low affinity iron permease; Region: Iron_permease; cl12096 706587000755 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 706587000756 UDP-glucose 4 epimerase, subgroup 2, extended (e) SDRs; Region: UDP_G4E_2_SDR_e; cd05234 706587000757 NAD binding site [chemical binding]; other site 706587000758 homodimer interface [polypeptide binding]; other site 706587000759 active site 706587000760 putative substrate binding site [chemical binding]; other site 706587000761 Predicted permeases [General function prediction only]; Region: COG0795 706587000762 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 706587000763 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 706587000764 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 706587000765 substrate binding pocket [chemical binding]; other site 706587000766 dimer interface [polypeptide binding]; other site 706587000767 inhibitor binding site; inhibition site 706587000768 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 706587000769 Putative Fe-S cluster; Region: FeS; pfam04060 706587000770 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 706587000771 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587000772 metal cluster binding site [ion binding]; other site 706587000773 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 706587000774 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 706587000775 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587000776 Prismane/CO dehydrogenase family; Region: Prismane; pfam03063 706587000777 ACS interaction site; other site 706587000778 CODH interaction site; other site 706587000779 metal cluster binding site [ion binding]; other site 706587000780 2-isopropylmalate synthase; Validated; Region: PRK00915 706587000781 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 706587000782 active site 706587000783 catalytic residues [active] 706587000784 metal binding site [ion binding]; metal-binding site 706587000785 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 706587000786 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 706587000787 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 706587000788 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587000789 FeS/SAM binding site; other site 706587000790 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 706587000791 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587000792 FeS/SAM binding site; other site 706587000793 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 706587000794 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 706587000795 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 706587000796 Protein of unknown function DUF116; Region: DUF116; cl00800 706587000797 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 706587000798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587000799 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 706587000800 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 706587000801 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706587000802 Ligand Binding Site [chemical binding]; other site 706587000803 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 706587000804 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 706587000805 active site 706587000806 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706587000807 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 706587000808 substrate binding pocket [chemical binding]; other site 706587000809 membrane-bound complex binding site; other site 706587000810 hinge residues; other site 706587000811 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 706587000812 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587000813 Response regulator receiver domain; Region: Response_reg; pfam00072 706587000814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587000815 active site 706587000816 phosphorylation site [posttranslational modification] 706587000817 intermolecular recognition site; other site 706587000818 dimerization interface [polypeptide binding]; other site 706587000819 GAF domain; Region: GAF_2; pfam13185 706587000820 GAF domain; Region: GAF; pfam01590 706587000821 Response regulator receiver domain; Region: Response_reg; pfam00072 706587000822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587000823 active site 706587000824 phosphorylation site [posttranslational modification] 706587000825 intermolecular recognition site; other site 706587000826 dimerization interface [polypeptide binding]; other site 706587000827 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706587000828 GAF domain; Region: GAF; pfam01590 706587000829 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 706587000830 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587000831 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000832 putative active site [active] 706587000833 heme pocket [chemical binding]; other site 706587000834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587000835 dimer interface [polypeptide binding]; other site 706587000836 phosphorylation site [posttranslational modification] 706587000837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587000838 ATP binding site [chemical binding]; other site 706587000839 Mg2+ binding site [ion binding]; other site 706587000840 G-X-G motif; other site 706587000841 Response regulator receiver domain; Region: Response_reg; pfam00072 706587000842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587000843 active site 706587000844 phosphorylation site [posttranslational modification] 706587000845 intermolecular recognition site; other site 706587000846 dimerization interface [polypeptide binding]; other site 706587000847 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587000848 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587000849 putative active site [active] 706587000850 heme pocket [chemical binding]; other site 706587000851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587000852 dimer interface [polypeptide binding]; other site 706587000853 phosphorylation site [posttranslational modification] 706587000854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587000855 ATP binding site [chemical binding]; other site 706587000856 Mg2+ binding site [ion binding]; other site 706587000857 G-X-G motif; other site 706587000858 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 706587000859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706587000860 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 706587000861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587000862 S-adenosylmethionine binding site [chemical binding]; other site 706587000863 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 706587000864 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 706587000865 putative metal binding site [ion binding]; other site 706587000866 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 706587000867 Methyltransferase domain; Region: Methyltransf_31; pfam13847 706587000868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587000869 S-adenosylmethionine binding site [chemical binding]; other site 706587000870 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 706587000871 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 706587000872 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587000873 Radical SAM superfamily; Region: Radical_SAM; pfam04055 706587000874 FeS/SAM binding site; other site 706587000875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 706587000876 binding surface 706587000877 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 706587000878 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 706587000879 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706587000880 catalytic residue [active] 706587000881 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 706587000882 heterotetramer interface [polypeptide binding]; other site 706587000883 active site pocket [active] 706587000884 cleavage site 706587000885 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 706587000886 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 706587000887 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 706587000888 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 706587000889 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587000890 active site 706587000891 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 706587000892 AMIN domain; Region: AMIN; pfam11741 706587000893 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 706587000894 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706587000895 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587000896 HAMP domain; Region: HAMP; pfam00672 706587000897 dimerization interface [polypeptide binding]; other site 706587000898 PAS domain; Region: PAS_9; pfam13426 706587000899 Response regulator receiver domain; Region: Response_reg; pfam00072 706587000900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587000901 active site 706587000902 phosphorylation site [posttranslational modification] 706587000903 intermolecular recognition site; other site 706587000904 dimerization interface [polypeptide binding]; other site 706587000905 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587000906 Cysteine-rich domain; Region: CCG; pfam02754 706587000907 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 706587000908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 706587000909 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 706587000910 FeoA domain; Region: FeoA; cl00838 706587000911 Response regulator receiver domain; Region: Response_reg; pfam00072 706587000912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587000913 active site 706587000914 phosphorylation site [posttranslational modification] 706587000915 intermolecular recognition site; other site 706587000916 dimerization interface [polypeptide binding]; other site 706587000917 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706587000918 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706587000919 metal binding site [ion binding]; metal-binding site 706587000920 active site 706587000921 I-site; other site 706587000922 PAS domain; Region: PAS; smart00091 706587000923 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587000924 PAS domain; Region: PAS_8; pfam13188 706587000925 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 706587000926 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587000927 dimer interface [polypeptide binding]; other site 706587000928 phosphorylation site [posttranslational modification] 706587000929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587000930 ATP binding site [chemical binding]; other site 706587000931 Mg2+ binding site [ion binding]; other site 706587000932 G-X-G motif; other site 706587000933 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587000934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587000935 active site 706587000936 phosphorylation site [posttranslational modification] 706587000937 intermolecular recognition site; other site 706587000938 dimerization interface [polypeptide binding]; other site 706587000939 Response regulator receiver domain; Region: Response_reg; pfam00072 706587000940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587000941 active site 706587000942 phosphorylation site [posttranslational modification] 706587000943 intermolecular recognition site; other site 706587000944 dimerization interface [polypeptide binding]; other site 706587000945 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 706587000946 putative binding surface; other site 706587000947 active site 706587000948 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 706587000949 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587000950 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 706587000951 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587000952 Uncharacterized conserved protein [Function unknown]; Region: COG1633 706587000953 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 706587000954 diiron binding motif [ion binding]; other site 706587000955 CsbD-like; Region: CsbD; cl17424 706587000956 CHASE3 domain; Region: CHASE3; pfam05227 706587000957 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 706587000958 HAMP domain; Region: HAMP; pfam00672 706587000959 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706587000960 dimer interface [polypeptide binding]; other site 706587000961 putative CheW interface [polypeptide binding]; other site 706587000962 HAMP domain; Region: HAMP; pfam00672 706587000963 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706587000964 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706587000965 dimer interface [polypeptide binding]; other site 706587000966 putative CheW interface [polypeptide binding]; other site 706587000967 Protein of unknown function (DUF401); Region: DUF401; cl00830 706587000968 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 706587000969 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 706587000970 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 706587000971 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 706587000972 G1 box; other site 706587000973 GTP/Mg2+ binding site [chemical binding]; other site 706587000974 G2 box; other site 706587000975 Switch I region; other site 706587000976 G3 box; other site 706587000977 Switch II region; other site 706587000978 G4 box; other site 706587000979 G5 box; other site 706587000980 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 706587000981 Catalytic domain of Protein Kinases; Region: PKc; cd00180 706587000982 active site 706587000983 ATP binding site [chemical binding]; other site 706587000984 substrate binding site [chemical binding]; other site 706587000985 activation loop (A-loop); other site 706587000986 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 706587000987 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706587000988 ligand binding site [chemical binding]; other site 706587000989 flexible hinge region; other site 706587000990 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 706587000991 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706587000992 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 706587000993 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 706587000994 metal ion-dependent adhesion site (MIDAS); other site 706587000995 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 706587000996 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 706587000997 P-loop; other site 706587000998 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587000999 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 706587001000 TPR repeat; Region: TPR_11; pfam13414 706587001001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587001002 binding surface 706587001003 TPR motif; other site 706587001004 TPR repeat; Region: TPR_11; pfam13414 706587001005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587001006 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587001007 TPR motif; other site 706587001008 binding surface 706587001009 TPR repeat; Region: TPR_11; pfam13414 706587001010 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587001011 binding surface 706587001012 TPR motif; other site 706587001013 TPR repeat; Region: TPR_11; pfam13414 706587001014 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 706587001015 ribonuclease PH; Reviewed; Region: rph; PRK00173 706587001016 Ribonuclease PH; Region: RNase_PH_bact; cd11362 706587001017 hexamer interface [polypeptide binding]; other site 706587001018 active site 706587001019 Response regulator receiver domain; Region: Response_reg; pfam00072 706587001020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587001021 active site 706587001022 phosphorylation site [posttranslational modification] 706587001023 intermolecular recognition site; other site 706587001024 dimerization interface [polypeptide binding]; other site 706587001025 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 706587001026 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 706587001027 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 706587001028 DctM-like transporters; Region: DctM; pfam06808 706587001029 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 706587001030 YGGT family; Region: YGGT; pfam02325 706587001031 Uncharacterized conserved protein [Function unknown]; Region: COG1872 706587001032 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 706587001033 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 706587001034 UbiA prenyltransferase family; Region: UbiA; pfam01040 706587001035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587001036 Response regulator receiver domain; Region: Response_reg; pfam00072 706587001037 active site 706587001038 phosphorylation site [posttranslational modification] 706587001039 intermolecular recognition site; other site 706587001040 dimerization interface [polypeptide binding]; other site 706587001041 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 706587001042 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706587001043 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587001044 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587001045 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 706587001046 MarR family; Region: MarR; pfam01047 706587001047 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 706587001048 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 706587001049 dimer interface [polypeptide binding]; other site 706587001050 ssDNA binding site [nucleotide binding]; other site 706587001051 tetramer (dimer of dimers) interface [polypeptide binding]; other site 706587001052 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357 706587001053 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 706587001054 serine O-acetyltransferase; Region: cysE; TIGR01172 706587001055 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 706587001056 trimer interface [polypeptide binding]; other site 706587001057 active site 706587001058 substrate binding site [chemical binding]; other site 706587001059 CoA binding site [chemical binding]; other site 706587001060 ketol-acid reductoisomerase; Provisional; Region: PRK05479 706587001061 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 706587001062 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 706587001063 Predicted ATPase [General function prediction only]; Region: COG4637 706587001064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587001065 Walker A/P-loop; other site 706587001066 ATP binding site [chemical binding]; other site 706587001067 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 706587001068 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587001069 Cysteine-rich domain; Region: CCG; pfam02754 706587001070 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 706587001071 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 706587001072 Peptidase family M23; Region: Peptidase_M23; pfam01551 706587001073 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 706587001074 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 706587001075 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 706587001076 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 706587001077 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587001078 catalytic loop [active] 706587001079 iron binding site [ion binding]; other site 706587001080 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 706587001081 4Fe-4S binding domain; Region: Fer4; pfam00037 706587001082 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 706587001083 dimer interface [polypeptide binding]; other site 706587001084 [2Fe-2S] cluster binding site [ion binding]; other site 706587001085 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 706587001086 SLBB domain; Region: SLBB; pfam10531 706587001087 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 706587001088 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 706587001089 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 706587001090 putative dimer interface [polypeptide binding]; other site 706587001091 [2Fe-2S] cluster binding site [ion binding]; other site 706587001092 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 706587001093 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 706587001094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587001095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587001096 dimer interface [polypeptide binding]; other site 706587001097 phosphorylation site [posttranslational modification] 706587001098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587001099 ATP binding site [chemical binding]; other site 706587001100 Mg2+ binding site [ion binding]; other site 706587001101 G-X-G motif; other site 706587001102 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 706587001103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587001104 active site 706587001105 phosphorylation site [posttranslational modification] 706587001106 intermolecular recognition site; other site 706587001107 dimerization interface [polypeptide binding]; other site 706587001108 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706587001109 DNA binding site [nucleotide binding] 706587001110 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 706587001111 active site 706587001112 dimer interface [polypeptide binding]; other site 706587001113 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587001114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587001115 active site 706587001116 phosphorylation site [posttranslational modification] 706587001117 intermolecular recognition site; other site 706587001118 dimerization interface [polypeptide binding]; other site 706587001119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587001120 Walker A motif; other site 706587001121 ATP binding site [chemical binding]; other site 706587001122 Walker B motif; other site 706587001123 arginine finger; other site 706587001124 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587001125 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587001126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 706587001127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587001128 dimer interface [polypeptide binding]; other site 706587001129 phosphorylation site [posttranslational modification] 706587001130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587001131 ATP binding site [chemical binding]; other site 706587001132 Mg2+ binding site [ion binding]; other site 706587001133 G-X-G motif; other site 706587001134 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 706587001135 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587001136 acyl-activating enzyme (AAE) consensus motif; other site 706587001137 AMP binding site [chemical binding]; other site 706587001138 active site 706587001139 CoA binding site [chemical binding]; other site 706587001140 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 706587001141 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706587001142 ligand binding site [chemical binding]; other site 706587001143 flexible hinge region; other site 706587001144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 706587001145 Walker A motif; other site 706587001146 ATP binding site [chemical binding]; other site 706587001147 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 706587001148 4Fe-4S binding domain; Region: Fer4_5; pfam12801 706587001149 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 706587001150 active site 706587001151 substrate-binding site [chemical binding]; other site 706587001152 metal-binding site [ion binding] 706587001153 GTP binding site [chemical binding]; other site 706587001154 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 706587001155 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 706587001156 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 706587001157 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706587001158 Zn binding site [ion binding]; other site 706587001159 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 706587001160 Zn binding site [ion binding]; other site 706587001161 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 706587001162 IHF dimer interface [polypeptide binding]; other site 706587001163 IHF - DNA interface [nucleotide binding]; other site 706587001164 Maf-like protein; Region: Maf; pfam02545 706587001165 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 706587001166 active site 706587001167 dimer interface [polypeptide binding]; other site 706587001168 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 706587001169 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 706587001170 catalytic residue [active] 706587001171 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 706587001172 trimer interface [polypeptide binding]; other site 706587001173 active site 706587001174 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 706587001175 cyclase homology domain; Region: CHD; cd07302 706587001176 nucleotidyl binding site; other site 706587001177 metal binding site [ion binding]; metal-binding site 706587001178 dimer interface [polypeptide binding]; other site 706587001179 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 706587001180 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 706587001181 active site 706587001182 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 706587001183 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 706587001184 hypothetical protein; Provisional; Region: PRK00468 706587001185 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 706587001186 RimM N-terminal domain; Region: RimM; pfam01782 706587001187 PRC-barrel domain; Region: PRC; pfam05239 706587001188 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 706587001189 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 706587001190 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 706587001191 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 706587001192 Walker A/P-loop; other site 706587001193 ATP binding site [chemical binding]; other site 706587001194 Q-loop/lid; other site 706587001195 ABC transporter signature motif; other site 706587001196 Walker B; other site 706587001197 D-loop; other site 706587001198 H-loop/switch region; other site 706587001199 Response regulator receiver domain; Region: Response_reg; pfam00072 706587001200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587001201 active site 706587001202 phosphorylation site [posttranslational modification] 706587001203 intermolecular recognition site; other site 706587001204 dimerization interface [polypeptide binding]; other site 706587001205 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 706587001206 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706587001207 active site 706587001208 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 706587001209 YWTD domain; Region: YWTD; pfam13570 706587001210 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 706587001211 PQQ-like domain; Region: PQQ_2; pfam13360 706587001212 Trp docking motif [polypeptide binding]; other site 706587001213 active site 706587001214 PQQ-like domain; Region: PQQ_2; pfam13360 706587001215 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 706587001216 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 706587001217 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 706587001218 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 706587001219 Rubrerythrin [Energy production and conversion]; Region: COG1592 706587001220 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 706587001221 binuclear metal center [ion binding]; other site 706587001222 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 706587001223 iron binding site [ion binding]; other site 706587001224 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 706587001225 metal binding site 2 [ion binding]; metal-binding site 706587001226 putative DNA binding helix; other site 706587001227 metal binding site 1 [ion binding]; metal-binding site 706587001228 dimer interface [polypeptide binding]; other site 706587001229 structural Zn2+ binding site [ion binding]; other site 706587001230 Amino acid permease; Region: AA_permease_2; pfam13520 706587001231 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 706587001232 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 706587001233 putative active site [active] 706587001234 oxyanion strand; other site 706587001235 catalytic triad [active] 706587001236 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 706587001237 putative active site pocket [active] 706587001238 4-fold oligomerization interface [polypeptide binding]; other site 706587001239 metal binding residues [ion binding]; metal-binding site 706587001240 3-fold/trimer interface [polypeptide binding]; other site 706587001241 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 706587001242 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 706587001243 hinge; other site 706587001244 active site 706587001245 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 706587001246 IHF - DNA interface [nucleotide binding]; other site 706587001247 IHF dimer interface [polypeptide binding]; other site 706587001248 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 706587001249 Catalytic site; other site 706587001250 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 706587001251 putative ADP-binding pocket [chemical binding]; other site 706587001252 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587001253 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 706587001254 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 706587001255 active site 706587001256 Substrate binding site; other site 706587001257 Mg++ binding site; other site 706587001258 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 706587001259 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587001260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 706587001261 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 706587001262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 706587001263 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 706587001264 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 706587001265 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 706587001266 PAS domain S-box; Region: sensory_box; TIGR00229 706587001267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587001268 putative active site [active] 706587001269 heme pocket [chemical binding]; other site 706587001270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587001271 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587001272 Walker A motif; other site 706587001273 ATP binding site [chemical binding]; other site 706587001274 Walker B motif; other site 706587001275 arginine finger; other site 706587001276 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587001277 NAD-dependent deacetylase; Provisional; Region: PRK00481 706587001278 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 706587001279 NAD+ binding site [chemical binding]; other site 706587001280 substrate binding site [chemical binding]; other site 706587001281 Zn binding site [ion binding]; other site 706587001282 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 706587001283 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 706587001284 23S rRNA interface [nucleotide binding]; other site 706587001285 L3 interface [polypeptide binding]; other site 706587001286 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 706587001287 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 706587001288 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 706587001289 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 706587001290 GTP1/OBG; Region: GTP1_OBG; pfam01018 706587001291 Obg GTPase; Region: Obg; cd01898 706587001292 G1 box; other site 706587001293 GTP/Mg2+ binding site [chemical binding]; other site 706587001294 Switch I region; other site 706587001295 G2 box; other site 706587001296 G3 box; other site 706587001297 Switch II region; other site 706587001298 G4 box; other site 706587001299 G5 box; other site 706587001300 gamma-glutamyl kinase; Provisional; Region: PRK05429 706587001301 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 706587001302 nucleotide binding site [chemical binding]; other site 706587001303 homotetrameric interface [polypeptide binding]; other site 706587001304 putative phosphate binding site [ion binding]; other site 706587001305 putative allosteric binding site; other site 706587001306 PUA domain; Region: PUA; pfam01472 706587001307 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 706587001308 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 706587001309 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587001310 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587001311 putative active site [active] 706587001312 heme pocket [chemical binding]; other site 706587001313 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 706587001314 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587001315 putative active site [active] 706587001316 heme pocket [chemical binding]; other site 706587001317 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587001318 putative active site [active] 706587001319 heme pocket [chemical binding]; other site 706587001320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587001321 Walker A motif; other site 706587001322 ATP binding site [chemical binding]; other site 706587001323 Walker B motif; other site 706587001324 arginine finger; other site 706587001325 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 706587001326 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587001327 non-specific DNA binding site [nucleotide binding]; other site 706587001328 salt bridge; other site 706587001329 sequence-specific DNA binding site [nucleotide binding]; other site 706587001330 Cupin domain; Region: Cupin_2; pfam07883 706587001331 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 706587001332 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 706587001333 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 706587001334 DctM-like transporters; Region: DctM; pfam06808 706587001335 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 706587001336 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 706587001337 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 706587001338 NAD(P) binding site [chemical binding]; other site 706587001339 catalytic residues [active] 706587001340 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 706587001341 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587001342 catalytic loop [active] 706587001343 iron binding site [ion binding]; other site 706587001344 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587001345 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 706587001346 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 706587001347 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 706587001348 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587001349 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587001350 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 706587001351 Amidohydrolase; Region: Amidohydro_5; pfam13594 706587001352 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 706587001353 active site 706587001354 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 706587001355 Ferredoxin [Energy production and conversion]; Region: COG1146 706587001356 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 706587001357 Uncharacterized conserved protein [Function unknown]; Region: COG2122; cl17892 706587001358 Amino acid synthesis; Region: AA_synth; pfam06684 706587001359 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 706587001360 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 706587001361 active site 706587001362 metal binding site [ion binding]; metal-binding site 706587001363 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 706587001364 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587001365 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587001366 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587001367 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 706587001368 iron-sulfur cluster [ion binding]; other site 706587001369 [2Fe-2S] cluster binding site [ion binding]; other site 706587001370 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 706587001371 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 706587001372 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 706587001373 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 706587001374 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587001375 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 706587001376 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 706587001377 substrate binding site [chemical binding]; other site 706587001378 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 706587001379 Protein export membrane protein; Region: SecD_SecF; cl14618 706587001380 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 706587001381 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587001382 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587001383 PAS domain; Region: PAS; smart00091 706587001384 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587001385 PAS fold; Region: PAS_3; pfam08447 706587001386 putative active site [active] 706587001387 heme pocket [chemical binding]; other site 706587001388 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587001389 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587001390 putative active site [active] 706587001391 heme pocket [chemical binding]; other site 706587001392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587001393 dimer interface [polypeptide binding]; other site 706587001394 phosphorylation site [posttranslational modification] 706587001395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587001396 ATP binding site [chemical binding]; other site 706587001397 Mg2+ binding site [ion binding]; other site 706587001398 G-X-G motif; other site 706587001399 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587001400 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587001401 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 706587001402 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587001403 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587001404 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587001405 TM-ABC transporter signature motif; other site 706587001406 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587001407 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587001408 TM-ABC transporter signature motif; other site 706587001409 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587001410 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587001411 Walker A/P-loop; other site 706587001412 ATP binding site [chemical binding]; other site 706587001413 Q-loop/lid; other site 706587001414 ABC transporter signature motif; other site 706587001415 Walker B; other site 706587001416 D-loop; other site 706587001417 H-loop/switch region; other site 706587001418 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587001419 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587001420 Walker A/P-loop; other site 706587001421 ATP binding site [chemical binding]; other site 706587001422 Q-loop/lid; other site 706587001423 ABC transporter signature motif; other site 706587001424 Walker B; other site 706587001425 D-loop; other site 706587001426 H-loop/switch region; other site 706587001427 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 706587001428 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706587001429 ligand binding site [chemical binding]; other site 706587001430 flexible hinge region; other site 706587001431 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 706587001432 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 706587001433 catalytic Zn binding site [ion binding]; other site 706587001434 NAD binding site [chemical binding]; other site 706587001435 structural Zn binding site [ion binding]; other site 706587001436 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 706587001437 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 706587001438 substrate binding pocket [chemical binding]; other site 706587001439 dimer interface [polypeptide binding]; other site 706587001440 inhibitor binding site; inhibition site 706587001441 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 706587001442 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 706587001443 B12 binding site [chemical binding]; other site 706587001444 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 706587001445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587001446 putative substrate translocation pore; other site 706587001447 D-galactonate transporter; Region: 2A0114; TIGR00893 706587001448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587001449 putative substrate translocation pore; other site 706587001450 D-galactonate transporter; Region: 2A0114; TIGR00893 706587001451 PAS domain S-box; Region: sensory_box; TIGR00229 706587001452 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587001453 putative active site [active] 706587001454 heme pocket [chemical binding]; other site 706587001455 PAS domain S-box; Region: sensory_box; TIGR00229 706587001456 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587001457 putative active site [active] 706587001458 heme pocket [chemical binding]; other site 706587001459 PAS fold; Region: PAS_4; pfam08448 706587001460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587001461 putative active site [active] 706587001462 heme pocket [chemical binding]; other site 706587001463 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587001464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587001465 Walker A motif; other site 706587001466 ATP binding site [chemical binding]; other site 706587001467 Walker B motif; other site 706587001468 arginine finger; other site 706587001469 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587001470 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 706587001471 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706587001472 Response regulator receiver domain; Region: Response_reg; pfam00072 706587001473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587001474 active site 706587001475 phosphorylation site [posttranslational modification] 706587001476 intermolecular recognition site; other site 706587001477 dimerization interface [polypeptide binding]; other site 706587001478 Response regulator receiver domain; Region: Response_reg; pfam00072 706587001479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587001480 active site 706587001481 phosphorylation site [posttranslational modification] 706587001482 intermolecular recognition site; other site 706587001483 dimerization interface [polypeptide binding]; other site 706587001484 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706587001485 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706587001486 metal binding site [ion binding]; metal-binding site 706587001487 active site 706587001488 I-site; other site 706587001489 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587001490 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587001491 Response regulator receiver domain; Region: Response_reg; pfam00072 706587001492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587001493 active site 706587001494 phosphorylation site [posttranslational modification] 706587001495 intermolecular recognition site; other site 706587001496 dimerization interface [polypeptide binding]; other site 706587001497 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706587001498 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706587001499 metal binding site [ion binding]; metal-binding site 706587001500 active site 706587001501 I-site; other site 706587001502 PAS domain; Region: PAS_9; pfam13426 706587001503 PAS domain S-box; Region: sensory_box; TIGR00229 706587001504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587001505 putative active site [active] 706587001506 heme pocket [chemical binding]; other site 706587001507 PAS domain S-box; Region: sensory_box; TIGR00229 706587001508 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587001509 putative active site [active] 706587001510 heme pocket [chemical binding]; other site 706587001511 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587001512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587001513 dimer interface [polypeptide binding]; other site 706587001514 phosphorylation site [posttranslational modification] 706587001515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587001516 ATP binding site [chemical binding]; other site 706587001517 Mg2+ binding site [ion binding]; other site 706587001518 G-X-G motif; other site 706587001519 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587001520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587001521 active site 706587001522 phosphorylation site [posttranslational modification] 706587001523 intermolecular recognition site; other site 706587001524 dimerization interface [polypeptide binding]; other site 706587001525 Response regulator receiver domain; Region: Response_reg; pfam00072 706587001526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587001527 active site 706587001528 phosphorylation site [posttranslational modification] 706587001529 intermolecular recognition site; other site 706587001530 dimerization interface [polypeptide binding]; other site 706587001531 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 706587001532 putative binding surface; other site 706587001533 active site 706587001534 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 706587001535 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 706587001536 Walker A/P-loop; other site 706587001537 ATP binding site [chemical binding]; other site 706587001538 Q-loop/lid; other site 706587001539 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 706587001540 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 706587001541 ABC transporter signature motif; other site 706587001542 Walker B; other site 706587001543 D-loop; other site 706587001544 H-loop/switch region; other site 706587001545 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 706587001546 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 706587001547 DNA binding residues [nucleotide binding] 706587001548 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587001549 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 706587001550 FtsX-like permease family; Region: FtsX; pfam02687 706587001551 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587001552 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 706587001553 FtsX-like permease family; Region: FtsX; pfam02687 706587001554 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 706587001555 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 706587001556 Walker A/P-loop; other site 706587001557 ATP binding site [chemical binding]; other site 706587001558 Q-loop/lid; other site 706587001559 ABC transporter signature motif; other site 706587001560 Walker B; other site 706587001561 D-loop; other site 706587001562 H-loop/switch region; other site 706587001563 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706587001564 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587001565 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587001566 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 706587001567 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 706587001568 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706587001569 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 706587001570 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 706587001571 Uncharacterized conserved protein [Function unknown]; Region: COG1262 706587001572 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 706587001573 Uncharacterized conserved protein [Function unknown]; Region: COG1262 706587001574 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 706587001575 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 706587001576 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 706587001577 PBP superfamily domain; Region: PBP_like_2; cl17296 706587001578 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 706587001579 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 706587001580 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587001581 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587001582 putative active site [active] 706587001583 heme pocket [chemical binding]; other site 706587001584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587001585 ATP binding site [chemical binding]; other site 706587001586 Mg2+ binding site [ion binding]; other site 706587001587 G-X-G motif; other site 706587001588 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706587001589 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 706587001590 active site 706587001591 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 706587001592 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 706587001593 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 706587001594 NAD binding site [chemical binding]; other site 706587001595 substrate binding site [chemical binding]; other site 706587001596 homodimer interface [polypeptide binding]; other site 706587001597 active site 706587001598 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 706587001599 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 706587001600 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 706587001601 large tegument protein UL36; Provisional; Region: PHA03247 706587001602 YtkA-like; Region: YtkA; pfam13115 706587001603 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 706587001604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587001605 TPR motif; other site 706587001606 TPR repeat; Region: TPR_11; pfam13414 706587001607 binding surface 706587001608 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 706587001609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587001610 FeS/SAM binding site; other site 706587001611 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 706587001612 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 706587001613 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 706587001614 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 706587001615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 706587001616 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 706587001617 dimer interface [polypeptide binding]; other site 706587001618 [2Fe-2S] cluster binding site [ion binding]; other site 706587001619 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587001620 dimerization interface [polypeptide binding]; other site 706587001621 Response regulator receiver domain; Region: Response_reg; pfam00072 706587001622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587001623 active site 706587001624 phosphorylation site [posttranslational modification] 706587001625 intermolecular recognition site; other site 706587001626 dimerization interface [polypeptide binding]; other site 706587001627 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 706587001628 Hemerythrin; Region: Hemerythrin; cd12107 706587001629 Fe binding site [ion binding]; other site 706587001630 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 706587001631 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 706587001632 putative active site; other site 706587001633 catalytic residue [active] 706587001634 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 706587001635 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 706587001636 putative NAD(P) binding site [chemical binding]; other site 706587001637 catalytic Zn binding site [ion binding]; other site 706587001638 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 706587001639 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 706587001640 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 706587001641 active site 706587001642 PilZ domain; Region: PilZ; pfam07238 706587001643 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 706587001644 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375 706587001645 active site 706587001646 Zn binding site [ion binding]; other site 706587001647 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587001648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587001649 active site 706587001650 phosphorylation site [posttranslational modification] 706587001651 intermolecular recognition site; other site 706587001652 dimerization interface [polypeptide binding]; other site 706587001653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587001654 Walker A motif; other site 706587001655 ATP binding site [chemical binding]; other site 706587001656 Walker B motif; other site 706587001657 arginine finger; other site 706587001658 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587001659 PAS domain; Region: PAS_9; pfam13426 706587001660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587001661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587001662 phosphorylation site [posttranslational modification] 706587001663 dimer interface [polypeptide binding]; other site 706587001664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587001665 ATP binding site [chemical binding]; other site 706587001666 Mg2+ binding site [ion binding]; other site 706587001667 G-X-G motif; other site 706587001668 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 706587001669 active site 706587001670 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 706587001671 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 706587001672 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 706587001673 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 706587001674 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 706587001675 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 706587001676 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 706587001677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 706587001678 Coenzyme A binding pocket [chemical binding]; other site 706587001679 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 706587001680 active site clefts [active] 706587001681 zinc binding site [ion binding]; other site 706587001682 dimer interface [polypeptide binding]; other site 706587001683 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 706587001684 IHF dimer interface [polypeptide binding]; other site 706587001685 IHF - DNA interface [nucleotide binding]; other site 706587001686 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 706587001687 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 706587001688 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 706587001689 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 706587001690 Predicted methyltransferases [General function prediction only]; Region: COG0313 706587001691 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 706587001692 putative SAM binding site [chemical binding]; other site 706587001693 putative homodimer interface [polypeptide binding]; other site 706587001694 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 706587001695 Domain of unknown function DUF20; Region: UPF0118; pfam01594 706587001696 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 706587001697 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 706587001698 putative active site [active] 706587001699 catalytic triad [active] 706587001700 putative dimer interface [polypeptide binding]; other site 706587001701 FOG: CBS domain [General function prediction only]; Region: COG0517 706587001702 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 706587001703 Transporter associated domain; Region: CorC_HlyC; smart01091 706587001704 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 706587001705 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 706587001706 substrate binding site [chemical binding]; other site 706587001707 glycogen synthase; Provisional; Region: glgA; PRK00654 706587001708 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 706587001709 ADP-binding pocket [chemical binding]; other site 706587001710 homodimer interface [polypeptide binding]; other site 706587001711 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 706587001712 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 706587001713 Walker A/P-loop; other site 706587001714 ATP binding site [chemical binding]; other site 706587001715 Q-loop/lid; other site 706587001716 ABC transporter signature motif; other site 706587001717 Walker B; other site 706587001718 D-loop; other site 706587001719 H-loop/switch region; other site 706587001720 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587001721 FtsX-like permease family; Region: FtsX; pfam02687 706587001722 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587001723 FtsX-like permease family; Region: FtsX; pfam02687 706587001724 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706587001725 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 706587001726 AAA domain; Region: AAA_30; pfam13604 706587001727 Family description; Region: UvrD_C_2; pfam13538 706587001728 Outer membrane efflux protein; Region: OEP; pfam02321 706587001729 Outer membrane efflux protein; Region: OEP; pfam02321 706587001730 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 706587001731 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587001732 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706587001733 active site 706587001734 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 706587001735 pyruvate kinase; Provisional; Region: PRK05826 706587001736 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 706587001737 domain interfaces; other site 706587001738 active site 706587001739 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 706587001740 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 706587001741 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 706587001742 active site 706587001743 catalytic site [active] 706587001744 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587001745 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587001746 putative active site [active] 706587001747 heme pocket [chemical binding]; other site 706587001748 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587001749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587001750 putative active site [active] 706587001751 heme pocket [chemical binding]; other site 706587001752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587001753 dimer interface [polypeptide binding]; other site 706587001754 phosphorylation site [posttranslational modification] 706587001755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587001756 ATP binding site [chemical binding]; other site 706587001757 Mg2+ binding site [ion binding]; other site 706587001758 G-X-G motif; other site 706587001759 Response regulator receiver domain; Region: Response_reg; pfam00072 706587001760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587001761 active site 706587001762 phosphorylation site [posttranslational modification] 706587001763 intermolecular recognition site; other site 706587001764 dimerization interface [polypeptide binding]; other site 706587001765 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587001766 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 706587001767 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 706587001768 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 706587001769 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 706587001770 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 706587001771 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 706587001772 metal ion-dependent adhesion site (MIDAS); other site 706587001773 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 706587001774 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 706587001775 trimer interface [polypeptide binding]; other site 706587001776 putative metal binding site [ion binding]; other site 706587001777 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 706587001778 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 706587001779 NADP binding site [chemical binding]; other site 706587001780 active site 706587001781 putative substrate binding site [chemical binding]; other site 706587001782 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 706587001783 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 706587001784 substrate binding site [chemical binding]; other site 706587001785 ligand binding site [chemical binding]; other site 706587001786 GMP synthase; Reviewed; Region: guaA; PRK00074 706587001787 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 706587001788 AMP/PPi binding site [chemical binding]; other site 706587001789 candidate oxyanion hole; other site 706587001790 catalytic triad [active] 706587001791 potential glutamine specificity residues [chemical binding]; other site 706587001792 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 706587001793 ATP Binding subdomain [chemical binding]; other site 706587001794 Ligand Binding sites [chemical binding]; other site 706587001795 Dimerization subdomain; other site 706587001796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587001797 S-adenosylmethionine binding site [chemical binding]; other site 706587001798 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 706587001799 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 706587001800 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 706587001801 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 706587001802 PA14 domain; Region: PA14; cl08459 706587001803 PA14 domain; Region: PA14; cl08459 706587001804 PA14 domain; Region: PA14; cl08459 706587001805 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 706587001806 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 706587001807 N-acetyl-D-glucosamine binding site [chemical binding]; other site 706587001808 catalytic residue [active] 706587001809 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 706587001810 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 706587001811 homodimer interface [polypeptide binding]; other site 706587001812 substrate-cofactor binding pocket; other site 706587001813 catalytic residue [active] 706587001814 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 706587001815 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 706587001816 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 706587001817 protein binding site [polypeptide binding]; other site 706587001818 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 706587001819 protein binding site [polypeptide binding]; other site 706587001820 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 706587001821 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 706587001822 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 706587001823 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 706587001824 active site 706587001825 metal binding site [ion binding]; metal-binding site 706587001826 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 706587001827 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 706587001828 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587001829 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 706587001830 acyl-activating enzyme (AAE) consensus motif; other site 706587001831 AMP binding site [chemical binding]; other site 706587001832 active site 706587001833 CoA binding site [chemical binding]; other site 706587001834 Dodecin; Region: Dodecin; pfam07311 706587001835 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 706587001836 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 706587001837 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 706587001838 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 706587001839 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 706587001840 active site 706587001841 DNA binding site [nucleotide binding] 706587001842 Int/Topo IB signature motif; other site 706587001843 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587001844 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 706587001845 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 706587001846 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 706587001847 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 706587001848 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 706587001849 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 706587001850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587001851 non-specific DNA binding site [nucleotide binding]; other site 706587001852 salt bridge; other site 706587001853 sequence-specific DNA binding site [nucleotide binding]; other site 706587001854 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 706587001855 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706587001856 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706587001857 DNA binding residues [nucleotide binding] 706587001858 KTSC domain; Region: KTSC; pfam13619 706587001859 Domain of unknown function DUF87; Region: DUF87; pfam01935 706587001860 AAA-like domain; Region: AAA_10; pfam12846 706587001861 SIR2-like domain; Region: SIR2_2; pfam13289 706587001862 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 706587001863 DNA binding residues [nucleotide binding] 706587001864 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 706587001865 Methyltransferase domain; Region: Methyltransf_26; pfam13659 706587001866 Domain of unknown function DUF87; Region: DUF87; pfam01935 706587001867 AAA-like domain; Region: AAA_10; pfam12846 706587001868 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 706587001869 short chain dehydrogenase; Provisional; Region: PRK07825 706587001870 classical (c) SDRs; Region: SDR_c; cd05233 706587001871 NAD(P) binding site [chemical binding]; other site 706587001872 active site 706587001873 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 706587001874 Helix-turn-helix domain; Region: HTH_17; pfam12728 706587001875 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587001876 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587001877 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587001878 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587001879 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 706587001880 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 706587001881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587001882 S-adenosylmethionine binding site [chemical binding]; other site 706587001883 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 706587001884 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 706587001885 N- and C-terminal domain interface [polypeptide binding]; other site 706587001886 active site 706587001887 MgATP binding site [chemical binding]; other site 706587001888 catalytic site [active] 706587001889 metal binding site [ion binding]; metal-binding site 706587001890 carbohydrate binding site [chemical binding]; other site 706587001891 putative homodimer interface [polypeptide binding]; other site 706587001892 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 706587001893 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 706587001894 hexamer (dimer of trimers) interface [polypeptide binding]; other site 706587001895 substrate binding site [chemical binding]; other site 706587001896 trimer interface [polypeptide binding]; other site 706587001897 Mn binding site [ion binding]; other site 706587001898 GxxExxY protein; Region: GxxExxY; TIGR04256 706587001899 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 706587001900 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 706587001901 putative active site [active] 706587001902 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 706587001903 active site 706587001904 NTP binding site [chemical binding]; other site 706587001905 metal binding triad [ion binding]; metal-binding site 706587001906 antibiotic binding site [chemical binding]; other site 706587001907 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587001908 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587001909 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587001910 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587001911 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587001912 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587001913 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587001914 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587001915 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587001916 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 706587001917 putative active site [active] 706587001918 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 706587001919 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587001920 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706587001921 TM-ABC transporter signature motif; other site 706587001922 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 706587001923 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706587001924 Walker A/P-loop; other site 706587001925 ATP binding site [chemical binding]; other site 706587001926 Q-loop/lid; other site 706587001927 ABC transporter signature motif; other site 706587001928 Walker B; other site 706587001929 D-loop; other site 706587001930 H-loop/switch region; other site 706587001931 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 706587001932 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 706587001933 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 706587001934 putative ligand binding site [chemical binding]; other site 706587001935 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 706587001936 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 706587001937 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 706587001938 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 706587001939 RNA binding site [nucleotide binding]; other site 706587001940 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 706587001941 putative dimer interface [polypeptide binding]; other site 706587001942 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706587001943 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587001944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587001945 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587001946 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 706587001947 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587001948 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587001949 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 706587001950 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 706587001951 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 706587001952 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587001953 catalytic loop [active] 706587001954 iron binding site [ion binding]; other site 706587001955 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587001956 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 706587001957 Thioredoxin; Region: Thioredoxin_4; pfam13462 706587001958 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 706587001959 dimer interface [polypeptide binding]; other site 706587001960 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 706587001961 catalytic triad [active] 706587001962 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587001963 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587001964 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587001965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587001966 active site 706587001967 phosphorylation site [posttranslational modification] 706587001968 intermolecular recognition site; other site 706587001969 dimerization interface [polypeptide binding]; other site 706587001970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587001971 Walker A motif; other site 706587001972 ATP binding site [chemical binding]; other site 706587001973 Walker B motif; other site 706587001974 arginine finger; other site 706587001975 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587001976 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 706587001977 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706587001978 4Fe-4S binding domain; Region: Fer4; pfam00037 706587001979 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587001980 4Fe-4S binding domain; Region: Fer4; pfam00037 706587001981 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 706587001982 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 706587001983 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 706587001984 iron-sulfur cluster [ion binding]; other site 706587001985 [2Fe-2S] cluster binding site [ion binding]; other site 706587001986 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 706587001987 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 706587001988 intrachain domain interface; other site 706587001989 interchain domain interface [polypeptide binding]; other site 706587001990 heme bH binding site [chemical binding]; other site 706587001991 Qi binding site; other site 706587001992 heme bL binding site [chemical binding]; other site 706587001993 Qo binding site; other site 706587001994 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 706587001995 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 706587001996 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 706587001997 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 706587001998 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 706587001999 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 706587002000 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 706587002001 Walker A/P-loop; other site 706587002002 ATP binding site [chemical binding]; other site 706587002003 Q-loop/lid; other site 706587002004 ABC transporter signature motif; other site 706587002005 Walker B; other site 706587002006 D-loop; other site 706587002007 H-loop/switch region; other site 706587002008 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587002009 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587002010 NosL; Region: NosL; cl01769 706587002011 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 706587002012 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 706587002013 catalytic residues [active] 706587002014 NosL; Region: NosL; cl01769 706587002015 NosL; Region: NosL; cl01769 706587002016 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587002017 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 706587002018 FtsX-like permease family; Region: FtsX; pfam02687 706587002019 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 706587002020 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 706587002021 Walker A/P-loop; other site 706587002022 ATP binding site [chemical binding]; other site 706587002023 Q-loop/lid; other site 706587002024 ABC transporter signature motif; other site 706587002025 Walker B; other site 706587002026 D-loop; other site 706587002027 H-loop/switch region; other site 706587002028 NosL; Region: NosL; cl01769 706587002029 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 706587002030 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 706587002031 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587002032 Transcriptional regulators [Transcription]; Region: GntR; COG1802 706587002033 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706587002034 DNA-binding site [nucleotide binding]; DNA binding site 706587002035 FCD domain; Region: FCD; pfam07729 706587002036 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 706587002037 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 706587002038 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 706587002039 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587002040 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 706587002041 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587002042 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587002043 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 706587002044 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 706587002045 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 706587002046 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 706587002047 DctM-like transporters; Region: DctM; pfam06808 706587002048 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 706587002049 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 706587002050 Predicted amidohydrolase [General function prediction only]; Region: COG0388 706587002051 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 706587002052 putative active site [active] 706587002053 catalytic triad [active] 706587002054 putative dimer interface [polypeptide binding]; other site 706587002055 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 706587002056 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 706587002057 phosphate binding site [ion binding]; other site 706587002058 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 706587002059 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 706587002060 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 706587002061 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587002062 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 706587002063 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587002064 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587002065 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 706587002066 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587002067 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 706587002068 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 706587002069 dimer interface [polypeptide binding]; other site 706587002070 PYR/PP interface [polypeptide binding]; other site 706587002071 TPP binding site [chemical binding]; other site 706587002072 substrate binding site [chemical binding]; other site 706587002073 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706587002074 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 706587002075 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 706587002076 TPP-binding site [chemical binding]; other site 706587002077 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 706587002078 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 706587002079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587002080 putative substrate translocation pore; other site 706587002081 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706587002082 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 706587002083 cobalt transport protein CbiM; Validated; Region: PRK06265 706587002084 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 706587002085 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 706587002086 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 706587002087 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 706587002088 dimer interface [polypeptide binding]; other site 706587002089 decamer (pentamer of dimers) interface [polypeptide binding]; other site 706587002090 catalytic triad [active] 706587002091 peroxidatic and resolving cysteines [active] 706587002092 cobalt transport protein CbiM; Validated; Region: PRK06265 706587002093 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 706587002094 PAS domain; Region: PAS_9; pfam13426 706587002095 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587002096 putative active site [active] 706587002097 heme pocket [chemical binding]; other site 706587002098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587002099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587002100 dimer interface [polypeptide binding]; other site 706587002101 phosphorylation site [posttranslational modification] 706587002102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587002103 ATP binding site [chemical binding]; other site 706587002104 Mg2+ binding site [ion binding]; other site 706587002105 G-X-G motif; other site 706587002106 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 706587002107 Ligand Binding Site [chemical binding]; other site 706587002108 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 706587002109 HAMP domain; Region: HAMP; pfam00672 706587002110 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 706587002111 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587002112 dimer interface [polypeptide binding]; other site 706587002113 phosphorylation site [posttranslational modification] 706587002114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587002115 ATP binding site [chemical binding]; other site 706587002116 Mg2+ binding site [ion binding]; other site 706587002117 G-X-G motif; other site 706587002118 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587002119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587002120 active site 706587002121 phosphorylation site [posttranslational modification] 706587002122 intermolecular recognition site; other site 706587002123 dimerization interface [polypeptide binding]; other site 706587002124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587002125 Walker A motif; other site 706587002126 ATP binding site [chemical binding]; other site 706587002127 Walker B motif; other site 706587002128 arginine finger; other site 706587002129 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587002130 Helix-turn-helix domain; Region: HTH_28; pfam13518 706587002131 Winged helix-turn helix; Region: HTH_29; pfam13551 706587002132 Homeodomain-like domain; Region: HTH_32; pfam13565 706587002133 Predicted permeases [General function prediction only]; Region: COG0730 706587002134 Response regulator receiver domain; Region: Response_reg; pfam00072 706587002135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587002136 active site 706587002137 phosphorylation site [posttranslational modification] 706587002138 intermolecular recognition site; other site 706587002139 dimerization interface [polypeptide binding]; other site 706587002140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587002141 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 706587002142 Walker A motif; other site 706587002143 ATP binding site [chemical binding]; other site 706587002144 Walker B motif; other site 706587002145 arginine finger; other site 706587002146 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 706587002147 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 706587002148 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 706587002149 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706587002150 catalytic residue [active] 706587002151 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 706587002152 DsrC like protein; Region: DsrC; cl01101 706587002153 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 706587002154 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 706587002155 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587002156 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587002157 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587002158 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 706587002159 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 706587002160 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 706587002161 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 706587002162 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 706587002163 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 706587002164 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 706587002165 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 706587002166 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706587002167 N-terminal plug; other site 706587002168 ligand-binding site [chemical binding]; other site 706587002169 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 706587002170 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 706587002171 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706587002172 N-terminal plug; other site 706587002173 ligand-binding site [chemical binding]; other site 706587002174 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 706587002175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587002176 Coenzyme A binding pocket [chemical binding]; other site 706587002177 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 706587002178 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 706587002179 putative active site [active] 706587002180 putative metal binding site [ion binding]; other site 706587002181 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 706587002182 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 706587002183 active site 706587002184 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 706587002185 GAF domain; Region: GAF; pfam01590 706587002186 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587002187 putative active site [active] 706587002188 heme pocket [chemical binding]; other site 706587002189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587002190 Walker A motif; other site 706587002191 ATP binding site [chemical binding]; other site 706587002192 Walker B motif; other site 706587002193 arginine finger; other site 706587002194 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587002195 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587002196 Cysteine-rich domain; Region: CCG; pfam02754 706587002197 Cysteine-rich domain; Region: CCG; pfam02754 706587002198 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 706587002199 lipoyl attachment site [posttranslational modification]; other site 706587002200 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 706587002201 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 706587002202 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 706587002203 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 706587002204 putative NAD(P) binding site [chemical binding]; other site 706587002205 catalytic Zn binding site [ion binding]; other site 706587002206 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 706587002207 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 706587002208 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 706587002209 alpha subunit interface [polypeptide binding]; other site 706587002210 TPP binding site [chemical binding]; other site 706587002211 heterodimer interface [polypeptide binding]; other site 706587002212 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706587002213 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 706587002214 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 706587002215 tetramer interface [polypeptide binding]; other site 706587002216 TPP-binding site [chemical binding]; other site 706587002217 heterodimer interface [polypeptide binding]; other site 706587002218 phosphorylation loop region [posttranslational modification] 706587002219 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 706587002220 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 706587002221 lipoyl synthase; Provisional; Region: PRK05481 706587002222 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587002223 FeS/SAM binding site; other site 706587002224 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 706587002225 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587002226 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 706587002227 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 706587002228 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 706587002229 E3 interaction surface; other site 706587002230 lipoyl attachment site [posttranslational modification]; other site 706587002231 e3 binding domain; Region: E3_binding; pfam02817 706587002232 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 706587002233 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 706587002234 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 706587002235 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 706587002236 dimer interface [polypeptide binding]; other site 706587002237 substrate binding site [chemical binding]; other site 706587002238 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 706587002239 dimer interface [polypeptide binding]; other site 706587002240 metal binding site [ion binding]; metal-binding site 706587002241 substrate binding site [chemical binding]; other site 706587002242 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 706587002243 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 706587002244 putative NAD(P) binding site [chemical binding]; other site 706587002245 putative active site [active] 706587002246 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 706587002247 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 706587002248 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 706587002249 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 706587002250 Predicted ATPase [General function prediction only]; Region: COG4637 706587002251 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 706587002252 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 706587002253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587002254 Walker A/P-loop; other site 706587002255 ATP binding site [chemical binding]; other site 706587002256 Q-loop/lid; other site 706587002257 ABC transporter signature motif; other site 706587002258 Walker B; other site 706587002259 D-loop; other site 706587002260 H-loop/switch region; other site 706587002261 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587002262 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706587002263 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 706587002264 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 706587002265 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 706587002266 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 706587002267 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587002268 FeS/SAM binding site; other site 706587002269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587002270 S-adenosylmethionine binding site [chemical binding]; other site 706587002271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 706587002272 PAS domain; Region: PAS_9; pfam13426 706587002273 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 706587002274 YWTD domain; Region: YWTD; cl17223 706587002275 YWTD domain; Region: YWTD; pfam13570 706587002276 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 706587002277 Trp docking motif [polypeptide binding]; other site 706587002278 active site 706587002279 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 706587002280 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587002281 acyl-activating enzyme (AAE) consensus motif; other site 706587002282 active site 706587002283 AMP binding site [chemical binding]; other site 706587002284 CoA binding site [chemical binding]; other site 706587002285 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 706587002286 putative active site [active] 706587002287 putative metal binding site [ion binding]; other site 706587002288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 706587002289 PAS domain; Region: PAS_9; pfam13426 706587002290 putative active site [active] 706587002291 heme pocket [chemical binding]; other site 706587002292 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587002293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587002294 Walker A motif; other site 706587002295 ATP binding site [chemical binding]; other site 706587002296 Walker B motif; other site 706587002297 arginine finger; other site 706587002298 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 706587002299 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 706587002300 reductive dehalogenase; Region: RDH; TIGR02486 706587002301 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 706587002302 reductive dehalogenase; Region: RDH; TIGR02486 706587002303 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 706587002304 acetyl-CoA decarbonylase/synthase complex subunit alpha; Validated; Region: PRK00941 706587002305 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 706587002306 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 706587002307 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 706587002308 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 706587002309 Predicted transcriptional regulator [Transcription]; Region: COG2378 706587002310 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706587002311 putative Zn2+ binding site [ion binding]; other site 706587002312 putative DNA binding site [nucleotide binding]; other site 706587002313 WYL domain; Region: WYL; pfam13280 706587002314 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 706587002315 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 706587002316 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 706587002317 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 706587002318 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 706587002319 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 706587002320 CRISPR-associated protein Cas4; Region: cas4; TIGR00372 706587002321 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 706587002322 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 706587002323 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 706587002324 dimer interface [polypeptide binding]; other site 706587002325 active site 706587002326 Schiff base residues; other site 706587002327 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 706587002328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587002329 Walker A motif; other site 706587002330 ATP binding site [chemical binding]; other site 706587002331 Walker B motif; other site 706587002332 arginine finger; other site 706587002333 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 706587002334 DNA-binding interface [nucleotide binding]; DNA binding site 706587002335 Uncharacterized conserved protein [Function unknown]; Region: COG2006 706587002336 Domain of unknown function (DUF362); Region: DUF362; pfam04015 706587002337 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 706587002338 Coenzyme A transferase; Region: CoA_trans; cl17247 706587002339 putative acyltransferase; Provisional; Region: PRK05790 706587002340 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 706587002341 dimer interface [polypeptide binding]; other site 706587002342 active site 706587002343 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 706587002344 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 706587002345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587002346 D-galactonate transporter; Region: 2A0114; TIGR00893 706587002347 putative substrate translocation pore; other site 706587002348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587002349 binding surface 706587002350 TPR motif; other site 706587002351 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 706587002352 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587002353 binding surface 706587002354 TPR motif; other site 706587002355 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 706587002356 Transposase IS200 like; Region: Y1_Tnp; cl00848 706587002357 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 706587002358 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 706587002359 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 706587002360 PAS domain S-box; Region: sensory_box; TIGR00229 706587002361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587002362 putative active site [active] 706587002363 heme pocket [chemical binding]; other site 706587002364 PAS fold; Region: PAS_4; pfam08448 706587002365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587002366 putative active site [active] 706587002367 heme pocket [chemical binding]; other site 706587002368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587002369 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587002370 Walker A motif; other site 706587002371 ATP binding site [chemical binding]; other site 706587002372 Walker B motif; other site 706587002373 arginine finger; other site 706587002374 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587002375 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587002376 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587002377 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587002378 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587002379 Cache domain; Region: Cache_1; pfam02743 706587002380 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 706587002381 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587002382 dimerization interface [polypeptide binding]; other site 706587002383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587002384 dimer interface [polypeptide binding]; other site 706587002385 phosphorylation site [posttranslational modification] 706587002386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587002387 ATP binding site [chemical binding]; other site 706587002388 G-X-G motif; other site 706587002389 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587002390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587002391 active site 706587002392 phosphorylation site [posttranslational modification] 706587002393 intermolecular recognition site; other site 706587002394 dimerization interface [polypeptide binding]; other site 706587002395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587002396 Walker A motif; other site 706587002397 ATP binding site [chemical binding]; other site 706587002398 Walker B motif; other site 706587002399 arginine finger; other site 706587002400 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587002401 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587002402 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 706587002403 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 706587002404 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 706587002405 DctM-like transporters; Region: DctM; pfam06808 706587002406 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 706587002407 Coenzyme A transferase; Region: CoA_trans; cl17247 706587002408 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706587002409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706587002410 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 706587002411 dimerization interface [polypeptide binding]; other site 706587002412 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 706587002413 Flavoprotein; Region: Flavoprotein; pfam02441 706587002414 hypothetical protein; Provisional; Region: PRK08296 706587002415 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 706587002416 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 706587002417 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 706587002418 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587002419 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 706587002420 acyl-activating enzyme (AAE) consensus motif; other site 706587002421 active site 706587002422 AMP binding site [chemical binding]; other site 706587002423 CoA binding site [chemical binding]; other site 706587002424 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 706587002425 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 706587002426 FOG: CBS domain [General function prediction only]; Region: COG0517 706587002427 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 706587002428 hypothetical protein; Provisional; Region: PRK02399 706587002429 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 706587002430 Protein of unknown function DUF89; Region: DUF89; cl15397 706587002431 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587002432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587002433 active site 706587002434 phosphorylation site [posttranslational modification] 706587002435 intermolecular recognition site; other site 706587002436 dimerization interface [polypeptide binding]; other site 706587002437 PAS domain S-box; Region: sensory_box; TIGR00229 706587002438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587002439 putative active site [active] 706587002440 heme pocket [chemical binding]; other site 706587002441 PAS domain S-box; Region: sensory_box; TIGR00229 706587002442 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587002443 putative active site [active] 706587002444 heme pocket [chemical binding]; other site 706587002445 PAS fold; Region: PAS_4; pfam08448 706587002446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587002447 putative active site [active] 706587002448 heme pocket [chemical binding]; other site 706587002449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 706587002450 Histidine kinase; Region: HisKA_2; pfam07568 706587002451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587002452 ATP binding site [chemical binding]; other site 706587002453 Mg2+ binding site [ion binding]; other site 706587002454 G-X-G motif; other site 706587002455 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587002456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587002457 active site 706587002458 phosphorylation site [posttranslational modification] 706587002459 intermolecular recognition site; other site 706587002460 dimerization interface [polypeptide binding]; other site 706587002461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587002462 Walker A motif; other site 706587002463 ATP binding site [chemical binding]; other site 706587002464 Walker B motif; other site 706587002465 arginine finger; other site 706587002466 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587002467 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587002468 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587002469 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587002470 putative active site [active] 706587002471 heme pocket [chemical binding]; other site 706587002472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587002473 dimer interface [polypeptide binding]; other site 706587002474 phosphorylation site [posttranslational modification] 706587002475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587002476 ATP binding site [chemical binding]; other site 706587002477 G-X-G motif; other site 706587002478 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 706587002479 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 706587002480 active site 706587002481 FMN binding site [chemical binding]; other site 706587002482 substrate binding site [chemical binding]; other site 706587002483 putative catalytic residue [active] 706587002484 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706587002485 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587002486 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 706587002487 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 706587002488 acyl-activating enzyme (AAE) consensus motif; other site 706587002489 active site 706587002490 AMP binding site [chemical binding]; other site 706587002491 substrate binding site [chemical binding]; other site 706587002492 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587002493 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587002494 TM-ABC transporter signature motif; other site 706587002495 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587002496 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587002497 TM-ABC transporter signature motif; other site 706587002498 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587002499 Type I periplasmic binding proteins of active transport systems that are predicted to be involved in transport of aromatic compounds such as 2-nitrobenzoic acid and alkylbenzenes; Region: PBP1_aromatic_compounds_like; cd06332 706587002500 putative ligand binding site [chemical binding]; other site 706587002501 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587002502 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587002503 Walker A/P-loop; other site 706587002504 ATP binding site [chemical binding]; other site 706587002505 Q-loop/lid; other site 706587002506 ABC transporter signature motif; other site 706587002507 Walker B; other site 706587002508 D-loop; other site 706587002509 H-loop/switch region; other site 706587002510 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587002511 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587002512 Walker A/P-loop; other site 706587002513 ATP binding site [chemical binding]; other site 706587002514 Q-loop/lid; other site 706587002515 ABC transporter signature motif; other site 706587002516 Walker B; other site 706587002517 D-loop; other site 706587002518 H-loop/switch region; other site 706587002519 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587002520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587002521 active site 706587002522 phosphorylation site [posttranslational modification] 706587002523 intermolecular recognition site; other site 706587002524 dimerization interface [polypeptide binding]; other site 706587002525 PAS fold; Region: PAS; pfam00989 706587002526 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587002527 putative active site [active] 706587002528 heme pocket [chemical binding]; other site 706587002529 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587002530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587002531 dimer interface [polypeptide binding]; other site 706587002532 phosphorylation site [posttranslational modification] 706587002533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587002534 ATP binding site [chemical binding]; other site 706587002535 Mg2+ binding site [ion binding]; other site 706587002536 G-X-G motif; other site 706587002537 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587002538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587002539 active site 706587002540 phosphorylation site [posttranslational modification] 706587002541 intermolecular recognition site; other site 706587002542 dimerization interface [polypeptide binding]; other site 706587002543 PAS domain S-box; Region: sensory_box; TIGR00229 706587002544 PAS fold; Region: PAS_4; pfam08448 706587002545 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 706587002546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587002547 putative active site [active] 706587002548 PAS fold; Region: PAS_3; pfam08447 706587002549 heme pocket [chemical binding]; other site 706587002550 GAF domain; Region: GAF_2; pfam13185 706587002551 GAF domain; Region: GAF; cl17456 706587002552 histidine kinase; Provisional; Region: PRK13557 706587002553 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587002554 putative active site [active] 706587002555 heme pocket [chemical binding]; other site 706587002556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587002557 dimer interface [polypeptide binding]; other site 706587002558 phosphorylation site [posttranslational modification] 706587002559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587002560 ATP binding site [chemical binding]; other site 706587002561 Mg2+ binding site [ion binding]; other site 706587002562 G-X-G motif; other site 706587002563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587002564 active site 706587002565 phosphorylation site [posttranslational modification] 706587002566 intermolecular recognition site; other site 706587002567 dimerization interface [polypeptide binding]; other site 706587002568 GAF domain; Region: GAF; pfam01590 706587002569 GAF domain; Region: GAF_2; pfam13185 706587002570 PAS fold; Region: PAS_4; pfam08448 706587002571 sensor protein ZraS; Provisional; Region: PRK10364 706587002572 GAF domain; Region: GAF; pfam01590 706587002573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587002574 dimer interface [polypeptide binding]; other site 706587002575 phosphorylation site [posttranslational modification] 706587002576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587002577 ATP binding site [chemical binding]; other site 706587002578 Mg2+ binding site [ion binding]; other site 706587002579 G-X-G motif; other site 706587002580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587002581 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706587002582 putative substrate translocation pore; other site 706587002583 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 706587002584 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 706587002585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 706587002586 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 706587002587 Coenzyme A transferase; Region: CoA_trans; cl17247 706587002588 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 706587002589 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 706587002590 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 706587002591 TPP-binding site [chemical binding]; other site 706587002592 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 706587002593 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 706587002594 dimer interface [polypeptide binding]; other site 706587002595 PYR/PP interface [polypeptide binding]; other site 706587002596 TPP binding site [chemical binding]; other site 706587002597 substrate binding site [chemical binding]; other site 706587002598 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 706587002599 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587002600 Transcriptional regulators [Transcription]; Region: GntR; COG1802 706587002601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706587002602 DNA-binding site [nucleotide binding]; DNA binding site 706587002603 FCD domain; Region: FCD; pfam07729 706587002604 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587002605 AAA domain; Region: AAA_21; pfam13304 706587002606 Walker A/P-loop; other site 706587002607 ATP binding site [chemical binding]; other site 706587002608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587002609 ABC transporter signature motif; other site 706587002610 Walker B; other site 706587002611 D-loop; other site 706587002612 H-loop/switch region; other site 706587002613 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 706587002614 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 706587002615 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 706587002616 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 706587002617 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 706587002618 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 706587002619 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 706587002620 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 706587002621 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587002622 catalytic loop [active] 706587002623 iron binding site [ion binding]; other site 706587002624 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 706587002625 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706587002626 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587002627 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 706587002628 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 706587002629 B12 binding site [chemical binding]; other site 706587002630 cobalt ligand [ion binding]; other site 706587002631 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 706587002632 Uroporphyrinogen decarboxylase (URO-D); Region: URO-D; pfam01208 706587002633 tetrahydromethanopterin S-methyltransferase subunit H; Provisional; Region: PRK00979 706587002634 Tetrahydromethanopterin S-methyltransferase, subunit H [Coenzyme metabolism]; Region: MtrH; cl15798 706587002635 PAS domain; Region: PAS_9; pfam13426 706587002636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 706587002637 putative active site [active] 706587002638 heme pocket [chemical binding]; other site 706587002639 PAS domain S-box; Region: sensory_box; TIGR00229 706587002640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587002641 putative active site [active] 706587002642 heme pocket [chemical binding]; other site 706587002643 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 706587002644 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706587002645 DNA binding residues [nucleotide binding] 706587002646 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 706587002647 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 706587002648 Walker A motif; other site 706587002649 homodimer interface [polypeptide binding]; other site 706587002650 ATP binding site [chemical binding]; other site 706587002651 hydroxycobalamin binding site [chemical binding]; other site 706587002652 Walker B motif; other site 706587002653 Predicted transcriptional regulators [Transcription]; Region: COG1695 706587002654 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 706587002655 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 706587002656 amphipathic channel; other site 706587002657 Asn-Pro-Ala signature motifs; other site 706587002658 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587002659 Restriction endonuclease; Region: Mrr_cat; pfam04471 706587002660 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 706587002661 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 706587002662 metal ion-dependent adhesion site (MIDAS); other site 706587002663 MoxR-like ATPases [General function prediction only]; Region: COG0714 706587002664 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 706587002665 Walker A motif; other site 706587002666 ATP binding site [chemical binding]; other site 706587002667 Walker B motif; other site 706587002668 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 706587002669 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 706587002670 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 706587002671 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 706587002672 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706587002673 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 706587002674 DNA binding residues [nucleotide binding] 706587002675 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 706587002676 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 706587002677 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 706587002678 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 706587002679 Putative mono-oxygenase ydhR; Region: ydhR; cl07420 706587002680 Response regulator receiver domain; Region: Response_reg; pfam00072 706587002681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587002682 active site 706587002683 phosphorylation site [posttranslational modification] 706587002684 intermolecular recognition site; other site 706587002685 dimerization interface [polypeptide binding]; other site 706587002686 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 706587002687 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587002688 acyl-activating enzyme (AAE) consensus motif; other site 706587002689 active site 706587002690 AMP binding site [chemical binding]; other site 706587002691 CoA binding site [chemical binding]; other site 706587002692 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587002693 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587002694 Walker A/P-loop; other site 706587002695 ATP binding site [chemical binding]; other site 706587002696 Q-loop/lid; other site 706587002697 ABC transporter signature motif; other site 706587002698 Walker B; other site 706587002699 D-loop; other site 706587002700 H-loop/switch region; other site 706587002701 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587002702 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587002703 Walker A/P-loop; other site 706587002704 ATP binding site [chemical binding]; other site 706587002705 Q-loop/lid; other site 706587002706 ABC transporter signature motif; other site 706587002707 Walker B; other site 706587002708 D-loop; other site 706587002709 H-loop/switch region; other site 706587002710 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587002711 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587002712 TM-ABC transporter signature motif; other site 706587002713 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587002714 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587002715 TM-ABC transporter signature motif; other site 706587002716 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587002717 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587002718 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587002719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587002720 active site 706587002721 phosphorylation site [posttranslational modification] 706587002722 intermolecular recognition site; other site 706587002723 dimerization interface [polypeptide binding]; other site 706587002724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587002725 Walker A motif; other site 706587002726 ATP binding site [chemical binding]; other site 706587002727 Walker B motif; other site 706587002728 arginine finger; other site 706587002729 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587002730 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587002731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587002732 putative active site [active] 706587002733 heme pocket [chemical binding]; other site 706587002734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587002735 dimer interface [polypeptide binding]; other site 706587002736 phosphorylation site [posttranslational modification] 706587002737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587002738 ATP binding site [chemical binding]; other site 706587002739 G-X-G motif; other site 706587002740 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587002741 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 706587002742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587002743 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 706587002744 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 706587002745 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 706587002746 nucleophile elbow; other site 706587002747 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 706587002748 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587002749 catalytic loop [active] 706587002750 iron binding site [ion binding]; other site 706587002751 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587002752 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 706587002753 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587002754 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587002755 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587002756 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 706587002757 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 706587002758 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706587002759 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587002760 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587002761 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 706587002762 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 706587002763 active site 706587002764 cosubstrate binding site; other site 706587002765 substrate binding site [chemical binding]; other site 706587002766 catalytic site [active] 706587002767 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 706587002768 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 706587002769 putative active site [active] 706587002770 putative metal binding site [ion binding]; other site 706587002771 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 706587002772 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 706587002773 putative NAD(P) binding site [chemical binding]; other site 706587002774 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 706587002775 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 706587002776 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 706587002777 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 706587002778 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587002779 acyl-activating enzyme (AAE) consensus motif; other site 706587002780 active site 706587002781 AMP binding site [chemical binding]; other site 706587002782 CoA binding site [chemical binding]; other site 706587002783 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587002784 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706587002785 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 706587002786 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 706587002787 active site 706587002788 dimer interface [polypeptide binding]; other site 706587002789 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 706587002790 Ligand Binding Site [chemical binding]; other site 706587002791 Molecular Tunnel; other site 706587002792 CHASE3 domain; Region: CHASE3; pfam05227 706587002793 CHASE3 domain; Region: CHASE3; pfam05227 706587002794 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 706587002795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587002796 dimerization interface [polypeptide binding]; other site 706587002797 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706587002798 dimer interface [polypeptide binding]; other site 706587002799 putative CheW interface [polypeptide binding]; other site 706587002800 CHASE3 domain; Region: CHASE3; pfam05227 706587002801 CHASE3 domain; Region: CHASE3; pfam05227 706587002802 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587002803 dimerization interface [polypeptide binding]; other site 706587002804 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706587002805 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706587002806 dimer interface [polypeptide binding]; other site 706587002807 putative CheW interface [polypeptide binding]; other site 706587002808 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 706587002809 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 706587002810 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 706587002811 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 706587002812 G1 box; other site 706587002813 putative GEF interaction site [polypeptide binding]; other site 706587002814 GTP/Mg2+ binding site [chemical binding]; other site 706587002815 Switch I region; other site 706587002816 G2 box; other site 706587002817 G3 box; other site 706587002818 Switch II region; other site 706587002819 G4 box; other site 706587002820 G5 box; other site 706587002821 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 706587002822 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 706587002823 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 706587002824 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 706587002825 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 706587002826 SLBB domain; Region: SLBB; pfam10531 706587002827 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 706587002828 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 706587002829 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 706587002830 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587002831 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 706587002832 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 706587002833 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 706587002834 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587002835 acyl-activating enzyme (AAE) consensus motif; other site 706587002836 AMP binding site [chemical binding]; other site 706587002837 active site 706587002838 CoA binding site [chemical binding]; other site 706587002839 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587002840 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 706587002841 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 706587002842 Bacterial sugar transferase; Region: Bac_transf; pfam02397 706587002843 O-Antigen ligase; Region: Wzy_C; pfam04932 706587002844 Right handed beta helix region; Region: Beta_helix; pfam13229 706587002845 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 706587002846 Chain length determinant protein; Region: Wzz; cl15801 706587002847 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 706587002848 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 706587002849 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 706587002850 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 706587002851 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 706587002852 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 706587002853 active site 706587002854 homodimer interface [polypeptide binding]; other site 706587002855 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587002856 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 706587002857 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 706587002858 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 706587002859 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 706587002860 active site 706587002861 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 706587002862 homodimer interface [polypeptide binding]; other site 706587002863 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 706587002864 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 706587002865 active site 706587002866 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 706587002867 Methyltransferase domain; Region: Methyltransf_31; pfam13847 706587002868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587002869 S-adenosylmethionine binding site [chemical binding]; other site 706587002870 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 706587002871 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 706587002872 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 706587002873 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 706587002874 PRC-barrel domain; Region: PRC; pfam05239 706587002875 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 706587002876 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 706587002877 [4Fe-4S] binding site [ion binding]; other site 706587002878 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 706587002879 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 706587002880 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 706587002881 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 706587002882 molybdopterin cofactor binding site; other site 706587002883 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 706587002884 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 706587002885 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 706587002886 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 706587002887 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 706587002888 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 706587002889 gating phenylalanine in ion channel; other site 706587002890 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706587002891 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706587002892 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 706587002893 dimerization interface [polypeptide binding]; other site 706587002894 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 706587002895 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706587002896 PBP superfamily domain; Region: PBP_like_2; cl17296 706587002897 Domain of unknown function (DUF202); Region: DUF202; cl09954 706587002898 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 706587002899 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587002900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587002901 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587002902 PilZ domain; Region: PilZ; pfam07238 706587002903 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 706587002904 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 706587002905 substrate binding pocket [chemical binding]; other site 706587002906 dimer interface [polypeptide binding]; other site 706587002907 inhibitor binding site; inhibition site 706587002908 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 706587002909 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 706587002910 B12 binding site [chemical binding]; other site 706587002911 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 706587002912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587002913 putative substrate translocation pore; other site 706587002914 D-galactonate transporter; Region: 2A0114; TIGR00893 706587002915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587002916 putative substrate translocation pore; other site 706587002917 D-galactonate transporter; Region: 2A0114; TIGR00893 706587002918 PAS domain S-box; Region: sensory_box; TIGR00229 706587002919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587002920 putative active site [active] 706587002921 heme pocket [chemical binding]; other site 706587002922 PAS domain S-box; Region: sensory_box; TIGR00229 706587002923 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587002924 putative active site [active] 706587002925 heme pocket [chemical binding]; other site 706587002926 PAS domain; Region: PAS_8; pfam13188 706587002927 PAS fold; Region: PAS_4; pfam08448 706587002928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 706587002929 putative active site [active] 706587002930 heme pocket [chemical binding]; other site 706587002931 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587002932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587002933 Walker A motif; other site 706587002934 ATP binding site [chemical binding]; other site 706587002935 Walker B motif; other site 706587002936 arginine finger; other site 706587002937 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587002938 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 706587002939 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 706587002940 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 706587002941 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 706587002942 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 706587002943 NAD(P) binding site [chemical binding]; other site 706587002944 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 706587002945 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 706587002946 active site 706587002947 catalytic residues [active] 706587002948 DNA binding site [nucleotide binding] 706587002949 Int/Topo IB signature motif; other site 706587002950 Helix-turn-helix domain; Region: HTH_17; cl17695 706587002951 DNA primase, catalytic core; Region: dnaG; TIGR01391 706587002952 CHC2 zinc finger; Region: zf-CHC2; cl17510 706587002953 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 706587002954 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 706587002955 active site 706587002956 metal binding site [ion binding]; metal-binding site 706587002957 interdomain interaction site; other site 706587002958 D5 N terminal like; Region: D5_N; smart00885 706587002959 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 706587002960 phage assembly protein; Region: IV; PHA00019 706587002961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 706587002962 salt bridge; other site 706587002963 non-specific DNA binding site [nucleotide binding]; other site 706587002964 sequence-specific DNA binding site [nucleotide binding]; other site 706587002965 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 706587002966 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 706587002967 catalytic residues [active] 706587002968 catalytic nucleophile [active] 706587002969 Presynaptic Site I dimer interface [polypeptide binding]; other site 706587002970 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 706587002971 Synaptic Flat tetramer interface [polypeptide binding]; other site 706587002972 Synaptic Site I dimer interface [polypeptide binding]; other site 706587002973 DNA binding site [nucleotide binding] 706587002974 Recombinase; Region: Recombinase; pfam07508 706587002975 ERCC4 domain; Region: ERCC4; pfam02732 706587002976 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 706587002977 Nitrogen regulatory protein P-II; Region: P-II; smart00938 706587002978 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 706587002979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587002980 active site 706587002981 phosphorylation site [posttranslational modification] 706587002982 intermolecular recognition site; other site 706587002983 dimerization interface [polypeptide binding]; other site 706587002984 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706587002985 DNA binding site [nucleotide binding] 706587002986 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 706587002987 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 706587002988 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 706587002989 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 706587002990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706587002991 motif II; other site 706587002992 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 706587002993 S-adenosylmethionine synthetase; Validated; Region: PRK05250 706587002994 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 706587002995 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 706587002996 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 706587002997 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587002998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587002999 binding surface 706587003000 TPR motif; other site 706587003001 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 706587003002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587003003 TPR motif; other site 706587003004 binding surface 706587003005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 706587003006 binding surface 706587003007 TPR motif; other site 706587003008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587003009 binding surface 706587003010 TPR motif; other site 706587003011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587003012 binding surface 706587003013 TPR motif; other site 706587003014 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587003015 binding surface 706587003016 TPR motif; other site 706587003017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587003018 binding surface 706587003019 TPR motif; other site 706587003020 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587003021 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587003022 CHAT domain; Region: CHAT; pfam12770 706587003023 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 706587003024 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 706587003025 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 706587003026 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 706587003027 YcfA-like protein; Region: YcfA; pfam07927 706587003028 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 706587003029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587003030 S-adenosylmethionine binding site [chemical binding]; other site 706587003031 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG3366 706587003032 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 706587003033 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 706587003034 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587003035 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 706587003036 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 706587003037 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 706587003038 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706587003039 active site 706587003040 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 706587003041 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 706587003042 B12 binding site [chemical binding]; other site 706587003043 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587003044 FeS/SAM binding site; other site 706587003045 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 706587003046 Ligand binding site; other site 706587003047 Putative Catalytic site; other site 706587003048 DXD motif; other site 706587003049 Uncharacterized conserved protein [Function unknown]; Region: COG5276 706587003050 TPR repeat; Region: TPR_11; pfam13414 706587003051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587003052 TPR motif; other site 706587003053 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587003054 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587003055 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587003056 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587003057 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587003058 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587003059 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587003060 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587003061 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587003062 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587003063 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587003064 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587003065 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587003066 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587003067 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587003068 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 706587003069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587003070 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706587003071 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587003072 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587003073 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 706587003074 Protein export membrane protein; Region: SecD_SecF; cl14618 706587003075 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 706587003076 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 706587003077 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 706587003078 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 706587003079 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 706587003080 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 706587003081 NAD(P) binding site [chemical binding]; other site 706587003082 homotetramer interface [polypeptide binding]; other site 706587003083 homodimer interface [polypeptide binding]; other site 706587003084 active site 706587003085 acyl carrier protein; Provisional; Region: acpP; PRK00982 706587003086 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 706587003087 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 706587003088 dimer interface [polypeptide binding]; other site 706587003089 active site 706587003090 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 706587003091 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 706587003092 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 706587003093 dimer interface [polypeptide binding]; other site 706587003094 active site 706587003095 glycine-pyridoxal phosphate binding site [chemical binding]; other site 706587003096 folate binding site [chemical binding]; other site 706587003097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587003098 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587003099 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 706587003100 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587003101 binding surface 706587003102 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587003103 TPR motif; other site 706587003104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 706587003105 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 706587003106 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 706587003107 high affinity sulphate transporter 1; Region: sulP; TIGR00815 706587003108 Sulfate transporter family; Region: Sulfate_transp; pfam00916 706587003109 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 706587003110 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587003111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587003112 active site 706587003113 phosphorylation site [posttranslational modification] 706587003114 intermolecular recognition site; other site 706587003115 dimerization interface [polypeptide binding]; other site 706587003116 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706587003117 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 706587003118 substrate binding pocket [chemical binding]; other site 706587003119 membrane-bound complex binding site; other site 706587003120 hinge residues; other site 706587003121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587003122 dimer interface [polypeptide binding]; other site 706587003123 phosphorylation site [posttranslational modification] 706587003124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587003125 ATP binding site [chemical binding]; other site 706587003126 Mg2+ binding site [ion binding]; other site 706587003127 G-X-G motif; other site 706587003128 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 706587003129 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 706587003130 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 706587003131 Putative Ig domain; Region: He_PIG; pfam05345 706587003132 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 706587003133 Cadherin repeat-like domain; Region: CA_like; cl15786 706587003134 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 706587003135 Putative Ig domain; Region: He_PIG; pfam05345 706587003136 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 706587003137 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 706587003138 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706587003139 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587003140 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 706587003141 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706587003142 catalytic residue [active] 706587003143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706587003144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706587003145 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 706587003146 putative dimerization interface [polypeptide binding]; other site 706587003147 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587003148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587003149 active site 706587003150 phosphorylation site [posttranslational modification] 706587003151 intermolecular recognition site; other site 706587003152 PAS fold; Region: PAS_4; pfam08448 706587003153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587003154 putative active site [active] 706587003155 heme pocket [chemical binding]; other site 706587003156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587003157 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587003158 Walker A motif; other site 706587003159 ATP binding site [chemical binding]; other site 706587003160 Walker B motif; other site 706587003161 arginine finger; other site 706587003162 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 706587003163 Response regulator receiver domain; Region: Response_reg; pfam00072 706587003164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587003165 active site 706587003166 phosphorylation site [posttranslational modification] 706587003167 intermolecular recognition site; other site 706587003168 dimerization interface [polypeptide binding]; other site 706587003169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587003170 dimerization interface [polypeptide binding]; other site 706587003171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587003172 dimer interface [polypeptide binding]; other site 706587003173 phosphorylation site [posttranslational modification] 706587003174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587003175 ATP binding site [chemical binding]; other site 706587003176 Mg2+ binding site [ion binding]; other site 706587003177 G-X-G motif; other site 706587003178 NMT1/THI5 like; Region: NMT1; pfam09084 706587003179 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 706587003180 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706587003181 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 706587003182 substrate binding site [chemical binding]; other site 706587003183 ATP binding site [chemical binding]; other site 706587003184 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 706587003185 GTP-binding protein LepA; Provisional; Region: PRK05433 706587003186 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 706587003187 G1 box; other site 706587003188 putative GEF interaction site [polypeptide binding]; other site 706587003189 GTP/Mg2+ binding site [chemical binding]; other site 706587003190 Switch I region; other site 706587003191 G2 box; other site 706587003192 G3 box; other site 706587003193 Switch II region; other site 706587003194 G4 box; other site 706587003195 G5 box; other site 706587003196 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 706587003197 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 706587003198 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 706587003199 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 706587003200 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 706587003201 catalytic core [active] 706587003202 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 706587003203 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 706587003204 putative dimer interface [polypeptide binding]; other site 706587003205 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706587003206 Ligand Binding Site [chemical binding]; other site 706587003207 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 706587003208 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 706587003209 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 706587003210 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 706587003211 NAD(P) binding site [chemical binding]; other site 706587003212 catalytic residues [active] 706587003213 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 706587003214 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 706587003215 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 706587003216 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 706587003217 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706587003218 motif II; other site 706587003219 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 706587003220 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 706587003221 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 706587003222 GAF domain; Region: GAF; cl17456 706587003223 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 706587003224 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587003225 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 706587003226 Peptidase family M50; Region: Peptidase_M50; pfam02163 706587003227 active site 706587003228 putative substrate binding region [chemical binding]; other site 706587003229 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587003230 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587003231 Outer membrane efflux protein; Region: OEP; pfam02321 706587003232 Outer membrane efflux protein; Region: OEP; pfam02321 706587003233 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 706587003234 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 706587003235 Ligand binding site; other site 706587003236 Putative Catalytic site; other site 706587003237 DXD motif; other site 706587003238 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 706587003239 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 706587003240 inhibitor-cofactor binding pocket; inhibition site 706587003241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587003242 catalytic residue [active] 706587003243 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587003244 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 706587003245 FtsX-like permease family; Region: FtsX; pfam02687 706587003246 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 706587003247 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 706587003248 hexamer interface [polypeptide binding]; other site 706587003249 ligand binding site [chemical binding]; other site 706587003250 putative active site [active] 706587003251 NAD(P) binding site [chemical binding]; other site 706587003252 Peptidase family M48; Region: Peptidase_M48; cl12018 706587003253 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 706587003254 homotrimer interaction site [polypeptide binding]; other site 706587003255 zinc binding site [ion binding]; other site 706587003256 CDP-binding sites; other site 706587003257 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 706587003258 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 706587003259 active site 706587003260 HIGH motif; other site 706587003261 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 706587003262 KMSKS motif; other site 706587003263 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 706587003264 tRNA binding surface [nucleotide binding]; other site 706587003265 anticodon binding site; other site 706587003266 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 706587003267 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 706587003268 Walker A/P-loop; other site 706587003269 ATP binding site [chemical binding]; other site 706587003270 Q-loop/lid; other site 706587003271 ABC transporter signature motif; other site 706587003272 Walker B; other site 706587003273 D-loop; other site 706587003274 H-loop/switch region; other site 706587003275 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 706587003276 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 706587003277 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 706587003278 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 706587003279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587003280 FeS/SAM binding site; other site 706587003281 AMIN domain; Region: AMIN; pfam11741 706587003282 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 706587003283 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 706587003284 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 706587003285 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 706587003286 putative catalytic cysteine [active] 706587003287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587003288 S-adenosylmethionine binding site [chemical binding]; other site 706587003289 Methyltransferase domain; Region: Methyltransf_23; pfam13489 706587003290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587003291 S-adenosylmethionine binding site [chemical binding]; other site 706587003292 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 706587003293 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706587003294 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587003295 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587003296 MarR family; Region: MarR_2; pfam12802 706587003297 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 706587003298 Walker A motif; other site 706587003299 Transcriptional regulator [Transcription]; Region: IclR; COG1414 706587003300 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 706587003301 Bacterial transcriptional regulator; Region: IclR; pfam01614 706587003302 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 706587003303 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 706587003304 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 706587003305 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587003306 catalytic loop [active] 706587003307 iron binding site [ion binding]; other site 706587003308 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587003309 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 706587003310 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587003311 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587003312 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 706587003313 thiS-thiF/thiG interaction site; other site 706587003314 Methyltransferase domain; Region: Methyltransf_31; pfam13847 706587003315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587003316 S-adenosylmethionine binding site [chemical binding]; other site 706587003317 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 706587003318 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 706587003319 Membrane protein of unknown function; Region: DUF360; pfam04020 706587003320 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 706587003321 diaminopimelate aminotransferase; Provisional; Region: PRK13983 706587003322 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650 706587003323 metal binding site [ion binding]; metal-binding site 706587003324 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 706587003325 DsrC like protein; Region: DsrC; pfam04358 706587003326 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 706587003327 TPR repeat; Region: TPR_11; pfam13414 706587003328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587003329 binding surface 706587003330 TPR motif; other site 706587003331 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587003332 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 706587003333 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 706587003334 putative acyl-acceptor binding pocket; other site 706587003335 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 706587003336 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706587003337 ligand binding site [chemical binding]; other site 706587003338 flexible hinge region; other site 706587003339 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 706587003340 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 706587003341 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587003342 Beta-Casp domain; Region: Beta-Casp; pfam10996 706587003343 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 706587003344 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 706587003345 active site 706587003346 multimer interface [polypeptide binding]; other site 706587003347 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14463 706587003348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587003349 FeS/SAM binding site; other site 706587003350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 706587003351 Predicted kinase [General function prediction only]; Region: COG0645 706587003352 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 706587003353 active site 706587003354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587003355 binding surface 706587003356 TPR motif; other site 706587003357 TPR repeat; Region: TPR_11; pfam13414 706587003358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587003359 binding surface 706587003360 TPR repeat; Region: TPR_11; pfam13414 706587003361 TPR motif; other site 706587003362 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 706587003363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587003364 binding surface 706587003365 TPR motif; other site 706587003366 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 706587003367 purine monophosphate binding site [chemical binding]; other site 706587003368 dimer interface [polypeptide binding]; other site 706587003369 putative catalytic residues [active] 706587003370 AIR carboxylase; Region: AIRC; pfam00731 706587003371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587003372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587003373 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 706587003374 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 706587003375 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 706587003376 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 706587003377 Walker A/P-loop; other site 706587003378 ATP binding site [chemical binding]; other site 706587003379 Q-loop/lid; other site 706587003380 ABC transporter signature motif; other site 706587003381 Walker B; other site 706587003382 D-loop; other site 706587003383 H-loop/switch region; other site 706587003384 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 706587003385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587003386 dimer interface [polypeptide binding]; other site 706587003387 conserved gate region; other site 706587003388 putative PBP binding loops; other site 706587003389 ABC-ATPase subunit interface; other site 706587003390 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 706587003391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587003392 S-adenosylmethionine binding site [chemical binding]; other site 706587003393 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 706587003394 UbiA prenyltransferase family; Region: UbiA; pfam01040 706587003395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 706587003396 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 706587003397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587003398 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 706587003399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587003400 S-adenosylmethionine binding site [chemical binding]; other site 706587003401 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 706587003402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587003403 Coenzyme A binding pocket [chemical binding]; other site 706587003404 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 706587003405 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 706587003406 active site 706587003407 phosphorylation site [posttranslational modification] 706587003408 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 706587003409 active pocket/dimerization site; other site 706587003410 active site 706587003411 phosphorylation site [posttranslational modification] 706587003412 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 706587003413 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 706587003414 Hpr binding site; other site 706587003415 active site 706587003416 homohexamer subunit interaction site [polypeptide binding]; other site 706587003417 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 706587003418 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 706587003419 catalytic residues [active] 706587003420 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 706587003421 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 706587003422 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 706587003423 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 706587003424 active site 706587003425 dimer interface [polypeptide binding]; other site 706587003426 motif 1; other site 706587003427 motif 2; other site 706587003428 motif 3; other site 706587003429 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 706587003430 anticodon binding site; other site 706587003431 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 706587003432 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 706587003433 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 706587003434 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587003435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587003436 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587003437 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 706587003438 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cd04100 706587003439 Dimer interface [polypeptide binding]; other site 706587003440 anticodon binding site; other site 706587003441 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 706587003442 homodimer interface [polypeptide binding]; other site 706587003443 motif 1; other site 706587003444 motif 2; other site 706587003445 active site 706587003446 motif 3; other site 706587003447 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 706587003448 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 706587003449 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706587003450 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 706587003451 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 706587003452 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 706587003453 catalytic motif [active] 706587003454 Zn binding site [ion binding]; other site 706587003455 RibD C-terminal domain; Region: RibD_C; cl17279 706587003456 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 706587003457 ATP cone domain; Region: ATP-cone; pfam03477 706587003458 NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910 706587003459 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 706587003460 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 706587003461 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 706587003462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706587003463 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 706587003464 dimerization interface [polypeptide binding]; other site 706587003465 substrate binding pocket [chemical binding]; other site 706587003466 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 706587003467 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 706587003468 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 706587003469 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 706587003470 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706587003471 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 706587003472 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 706587003473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587003474 Walker A motif; other site 706587003475 ATP binding site [chemical binding]; other site 706587003476 Walker B motif; other site 706587003477 arginine finger; other site 706587003478 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 706587003479 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 706587003480 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 706587003481 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 706587003482 Response regulator receiver domain; Region: Response_reg; pfam00072 706587003483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587003484 active site 706587003485 phosphorylation site [posttranslational modification] 706587003486 intermolecular recognition site; other site 706587003487 dimerization interface [polypeptide binding]; other site 706587003488 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 706587003489 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 706587003490 ATP binding site [chemical binding]; other site 706587003491 Walker B motif; other site 706587003492 recombinase A; Provisional; Region: recA; PRK09354 706587003493 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 706587003494 hexamer interface [polypeptide binding]; other site 706587003495 Walker A motif; other site 706587003496 ATP binding site [chemical binding]; other site 706587003497 Walker B motif; other site 706587003498 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 706587003499 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 706587003500 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 706587003501 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 706587003502 lipoyl attachment site [posttranslational modification]; other site 706587003503 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 706587003504 TPR repeat; Region: TPR_11; pfam13414 706587003505 TPR repeat; Region: TPR_11; pfam13414 706587003506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587003507 binding surface 706587003508 TPR motif; other site 706587003509 TPR repeat; Region: TPR_11; pfam13414 706587003510 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 706587003511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706587003512 motif II; other site 706587003513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587003514 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587003515 biotin synthase; Region: bioB; TIGR00433 706587003516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587003517 FeS/SAM binding site; other site 706587003518 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 706587003519 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 706587003520 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 706587003521 putative dimer interface [polypeptide binding]; other site 706587003522 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 706587003523 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587003524 substrate binding site [chemical binding]; other site 706587003525 oxyanion hole (OAH) forming residues; other site 706587003526 trimer interface [polypeptide binding]; other site 706587003527 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 706587003528 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 706587003529 active site 706587003530 PHP Thumb interface [polypeptide binding]; other site 706587003531 metal binding site [ion binding]; metal-binding site 706587003532 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 706587003533 generic binding surface II; other site 706587003534 generic binding surface I; other site 706587003535 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 706587003536 putative homodimer interface [polypeptide binding]; other site 706587003537 putative active site pocket [active] 706587003538 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 706587003539 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 706587003540 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587003541 FeS/SAM binding site; other site 706587003542 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 706587003543 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 706587003544 Fic family protein [Function unknown]; Region: COG3177 706587003545 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 706587003546 Fic/DOC family; Region: Fic; pfam02661 706587003547 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 706587003548 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 706587003549 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 706587003550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587003551 active site 706587003552 phosphorylation site [posttranslational modification] 706587003553 intermolecular recognition site; other site 706587003554 dimerization interface [polypeptide binding]; other site 706587003555 LytTr DNA-binding domain; Region: LytTR; smart00850 706587003556 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 706587003557 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 706587003558 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 706587003559 Histidine kinase; Region: His_kinase; pfam06580 706587003560 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 706587003561 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 706587003562 Carbon starvation protein CstA; Region: CstA; pfam02554 706587003563 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 706587003564 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 706587003565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706587003566 motif II; other site 706587003567 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 706587003568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706587003569 motif II; other site 706587003570 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 706587003571 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 706587003572 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 706587003573 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 706587003574 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 706587003575 dimer interface [polypeptide binding]; other site 706587003576 putative functional site; other site 706587003577 putative MPT binding site; other site 706587003578 PBP superfamily domain; Region: PBP_like; pfam12727 706587003579 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 706587003580 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 706587003581 dimer interface [polypeptide binding]; other site 706587003582 putative functional site; other site 706587003583 putative MPT binding site; other site 706587003584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587003585 D-galactonate transporter; Region: 2A0114; TIGR00893 706587003586 putative substrate translocation pore; other site 706587003587 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 706587003588 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 706587003589 putative active site [active] 706587003590 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 706587003591 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 706587003592 HSP70 interaction site [polypeptide binding]; other site 706587003593 2-isopropylmalate synthase; Validated; Region: PRK00915 706587003594 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 706587003595 active site 706587003596 catalytic residues [active] 706587003597 metal binding site [ion binding]; metal-binding site 706587003598 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 706587003599 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587003600 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587003601 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 706587003602 6-phosphofructokinase; Region: PLN02884 706587003603 active site 706587003604 ADP/pyrophosphate binding site [chemical binding]; other site 706587003605 dimerization interface [polypeptide binding]; other site 706587003606 allosteric effector site; other site 706587003607 fructose-1,6-bisphosphate binding site; other site 706587003608 GTP-binding protein YchF; Reviewed; Region: PRK09601 706587003609 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 706587003610 G1 box; other site 706587003611 GTP/Mg2+ binding site [chemical binding]; other site 706587003612 Switch I region; other site 706587003613 G3 box; other site 706587003614 Switch II region; other site 706587003615 G4 box; other site 706587003616 G5 box; other site 706587003617 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 706587003618 Putative zinc-finger; Region: zf-HC2; pfam13490 706587003619 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 706587003620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706587003621 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706587003622 DNA binding residues [nucleotide binding] 706587003623 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 706587003624 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706587003625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587003626 homodimer interface [polypeptide binding]; other site 706587003627 catalytic residue [active] 706587003628 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 706587003629 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 706587003630 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 706587003631 catalytic site [active] 706587003632 subunit interface [polypeptide binding]; other site 706587003633 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 706587003634 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 706587003635 putative GTP cyclohydrolase; Provisional; Region: PRK13674 706587003636 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 706587003637 active site 706587003638 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 706587003639 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 706587003640 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 706587003641 oligomer interface [polypeptide binding]; other site 706587003642 putative active site [active] 706587003643 metal binding site [ion binding]; metal-binding site 706587003644 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706587003645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706587003646 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706587003647 dimerization interface [polypeptide binding]; other site 706587003648 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 706587003649 active site 2 [active] 706587003650 active site 1 [active] 706587003651 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 706587003652 active site 2 [active] 706587003653 active site 1 [active] 706587003654 Predicted permeases [General function prediction only]; Region: COG0679 706587003655 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 706587003656 trimerization site [polypeptide binding]; other site 706587003657 active site 706587003658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706587003659 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 706587003660 NAD(P) binding site [chemical binding]; other site 706587003661 active site 706587003662 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 706587003663 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 706587003664 tellurium resistance terB-like protein; Region: terB_like; cd07177 706587003665 metal binding site [ion binding]; metal-binding site 706587003666 Double zinc ribbon; Region: DZR; pfam12773 706587003667 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 706587003668 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 706587003669 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 706587003670 active site 706587003671 NTP binding site [chemical binding]; other site 706587003672 metal binding triad [ion binding]; metal-binding site 706587003673 antibiotic binding site [chemical binding]; other site 706587003674 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 706587003675 TPR repeat; Region: TPR_11; pfam13414 706587003676 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587003677 binding surface 706587003678 TPR motif; other site 706587003679 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587003680 TPR repeat; Region: TPR_11; pfam13414 706587003681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587003682 binding surface 706587003683 TPR motif; other site 706587003684 TPR repeat; Region: TPR_11; pfam13414 706587003685 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cd10546 706587003686 putative active site [active] 706587003687 redox center [active] 706587003688 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 706587003689 Thioredoxin; Region: Thioredoxin_4; cl17273 706587003690 sporulation sigma factor SigK; Reviewed; Region: PRK05803 706587003691 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587003692 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 706587003693 FtsX-like permease family; Region: FtsX; pfam02687 706587003694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 706587003695 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 706587003696 diiron binding motif [ion binding]; other site 706587003697 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 706587003698 Ferritin-like domain; Region: Ferritin; pfam00210 706587003699 ferroxidase diiron center [ion binding]; other site 706587003700 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 706587003701 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587003702 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587003703 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 706587003704 ATP synthase I chain; Region: ATP_synt_I; pfam03899 706587003705 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 706587003706 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 706587003707 ATP synthase subunit C; Region: ATP-synt_C; cl00466 706587003708 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 706587003709 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 706587003710 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 706587003711 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 706587003712 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 706587003713 replicative DNA helicase; Region: DnaB; TIGR00665 706587003714 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 706587003715 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 706587003716 Walker A motif; other site 706587003717 ATP binding site [chemical binding]; other site 706587003718 Walker B motif; other site 706587003719 DNA binding loops [nucleotide binding] 706587003720 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 706587003721 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 706587003722 active site 706587003723 catalytic residues [active] 706587003724 metal binding site [ion binding]; metal-binding site 706587003725 Cache domain; Region: Cache_1; pfam02743 706587003726 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 706587003727 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 706587003728 dimer interface [polypeptide binding]; other site 706587003729 anticodon binding site; other site 706587003730 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 706587003731 homodimer interface [polypeptide binding]; other site 706587003732 motif 1; other site 706587003733 active site 706587003734 motif 2; other site 706587003735 GAD domain; Region: GAD; pfam02938 706587003736 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 706587003737 motif 3; other site 706587003738 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 706587003739 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 706587003740 dimer interface [polypeptide binding]; other site 706587003741 motif 1; other site 706587003742 active site 706587003743 motif 2; other site 706587003744 motif 3; other site 706587003745 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 706587003746 anticodon binding site; other site 706587003747 phosphomannomutase CpsG; Provisional; Region: PRK15414 706587003748 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 706587003749 active site 706587003750 substrate binding site [chemical binding]; other site 706587003751 metal binding site [ion binding]; metal-binding site 706587003752 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 706587003753 [2Fe-2S] cluster binding site [ion binding]; other site 706587003754 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 706587003755 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706587003756 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587003757 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 706587003758 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 706587003759 Substrate binding site; other site 706587003760 Cupin domain; Region: Cupin_2; cl17218 706587003761 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706587003762 active site 706587003763 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 706587003764 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 706587003765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587003766 catalytic residue [active] 706587003767 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 706587003768 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 706587003769 active site 706587003770 HIGH motif; other site 706587003771 KMSKS motif; other site 706587003772 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 706587003773 tRNA binding surface [nucleotide binding]; other site 706587003774 anticodon binding site; other site 706587003775 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 706587003776 dimer interface [polypeptide binding]; other site 706587003777 putative tRNA-binding site [nucleotide binding]; other site 706587003778 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 706587003779 Zn binding site [ion binding]; other site 706587003780 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 706587003781 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 706587003782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587003783 S-adenosylmethionine binding site [chemical binding]; other site 706587003784 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 706587003785 active site 706587003786 catalytic site [active] 706587003787 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 706587003788 active site 2 [active] 706587003789 active site 1 [active] 706587003790 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 706587003791 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587003792 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 706587003793 acyl-activating enzyme (AAE) consensus motif; other site 706587003794 acyl-activating enzyme (AAE) consensus motif; other site 706587003795 putative AMP binding site [chemical binding]; other site 706587003796 putative active site [active] 706587003797 putative CoA binding site [chemical binding]; other site 706587003798 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 706587003799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587003800 dimer interface [polypeptide binding]; other site 706587003801 conserved gate region; other site 706587003802 putative PBP binding loops; other site 706587003803 ABC-ATPase subunit interface; other site 706587003804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587003805 dimer interface [polypeptide binding]; other site 706587003806 conserved gate region; other site 706587003807 putative PBP binding loops; other site 706587003808 ABC-ATPase subunit interface; other site 706587003809 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 706587003810 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 706587003811 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 706587003812 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 706587003813 Walker A/P-loop; other site 706587003814 ATP binding site [chemical binding]; other site 706587003815 Q-loop/lid; other site 706587003816 ABC transporter signature motif; other site 706587003817 Walker B; other site 706587003818 D-loop; other site 706587003819 H-loop/switch region; other site 706587003820 TOBE domain; Region: TOBE_2; pfam08402 706587003821 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 706587003822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587003823 FeS/SAM binding site; other site 706587003824 Oxygen-sensitive ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Region: NrdD; COG1328 706587003825 ATP cone domain; Region: ATP-cone; pfam03477 706587003826 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 706587003827 elongation factor G; Reviewed; Region: PRK00007 706587003828 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 706587003829 G1 box; other site 706587003830 putative GEF interaction site [polypeptide binding]; other site 706587003831 GTP/Mg2+ binding site [chemical binding]; other site 706587003832 Switch I region; other site 706587003833 G2 box; other site 706587003834 G3 box; other site 706587003835 Switch II region; other site 706587003836 G4 box; other site 706587003837 G5 box; other site 706587003838 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 706587003839 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 706587003840 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 706587003841 YacP-like NYN domain; Region: NYN_YacP; cl01491 706587003842 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 706587003843 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 706587003844 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587003845 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587003846 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587003847 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 706587003848 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 706587003849 active site 706587003850 dimerization interface [polypeptide binding]; other site 706587003851 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 706587003852 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 706587003853 generic binding surface II; other site 706587003854 generic binding surface I; other site 706587003855 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 706587003856 DsrE/DsrF-like family; Region: DrsE; pfam02635 706587003857 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 706587003858 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 706587003859 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 706587003860 P loop; other site 706587003861 Nucleotide binding site [chemical binding]; other site 706587003862 DTAP/Switch II; other site 706587003863 Switch I; other site 706587003864 Proline dehydrogenase; Region: Pro_dh; cl03282 706587003865 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 706587003866 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 706587003867 Glutamate binding site [chemical binding]; other site 706587003868 homodimer interface [polypeptide binding]; other site 706587003869 NAD binding site [chemical binding]; other site 706587003870 catalytic residues [active] 706587003871 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 706587003872 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 706587003873 dimer interface [polypeptide binding]; other site 706587003874 acyl-activating enzyme (AAE) consensus motif; other site 706587003875 putative active site [active] 706587003876 AMP binding site [chemical binding]; other site 706587003877 putative CoA binding site [chemical binding]; other site 706587003878 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 706587003879 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 706587003880 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587003881 non-specific DNA binding site [nucleotide binding]; other site 706587003882 salt bridge; other site 706587003883 sequence-specific DNA binding site [nucleotide binding]; other site 706587003884 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 706587003885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587003886 active site 706587003887 phosphorylation site [posttranslational modification] 706587003888 intermolecular recognition site; other site 706587003889 dimerization interface [polypeptide binding]; other site 706587003890 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587003891 Zn2+ binding site [ion binding]; other site 706587003892 Mg2+ binding site [ion binding]; other site 706587003893 Protein of unknown function (DUF972); Region: DUF972; pfam06156 706587003894 PAS domain S-box; Region: sensory_box; TIGR00229 706587003895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587003896 putative active site [active] 706587003897 heme pocket [chemical binding]; other site 706587003898 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587003899 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587003900 putative active site [active] 706587003901 heme pocket [chemical binding]; other site 706587003902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587003903 putative active site [active] 706587003904 heme pocket [chemical binding]; other site 706587003905 PAS domain S-box; Region: sensory_box; TIGR00229 706587003906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587003907 putative active site [active] 706587003908 heme pocket [chemical binding]; other site 706587003909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587003910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587003911 dimer interface [polypeptide binding]; other site 706587003912 phosphorylation site [posttranslational modification] 706587003913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587003914 ATP binding site [chemical binding]; other site 706587003915 Mg2+ binding site [ion binding]; other site 706587003916 G-X-G motif; other site 706587003917 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587003918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587003919 active site 706587003920 phosphorylation site [posttranslational modification] 706587003921 intermolecular recognition site; other site 706587003922 dimerization interface [polypeptide binding]; other site 706587003923 Uncharacterized conserved protein [Function unknown]; Region: COG0398 706587003924 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 706587003925 YcxB-like protein; Region: YcxB; pfam14317 706587003926 FOG: CBS domain [General function prediction only]; Region: COG0517 706587003927 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 706587003928 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 706587003929 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 706587003930 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 706587003931 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 706587003932 homodimer interface [polypeptide binding]; other site 706587003933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587003934 catalytic residue [active] 706587003935 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 706587003936 Dehydroquinase class II; Region: DHquinase_II; pfam01220 706587003937 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 706587003938 trimer interface [polypeptide binding]; other site 706587003939 active site 706587003940 dimer interface [polypeptide binding]; other site 706587003941 Response regulator receiver domain; Region: Response_reg; pfam00072 706587003942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587003943 active site 706587003944 phosphorylation site [posttranslational modification] 706587003945 intermolecular recognition site; other site 706587003946 dimerization interface [polypeptide binding]; other site 706587003947 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587003948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587003949 active site 706587003950 phosphorylation site [posttranslational modification] 706587003951 intermolecular recognition site; other site 706587003952 dimerization interface [polypeptide binding]; other site 706587003953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587003954 Walker A motif; other site 706587003955 ATP binding site [chemical binding]; other site 706587003956 Walker B motif; other site 706587003957 arginine finger; other site 706587003958 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587003959 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587003960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587003961 dimer interface [polypeptide binding]; other site 706587003962 phosphorylation site [posttranslational modification] 706587003963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587003964 ATP binding site [chemical binding]; other site 706587003965 Mg2+ binding site [ion binding]; other site 706587003966 G-X-G motif; other site 706587003967 Chorismate mutase type II; Region: CM_2; pfam01817 706587003968 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 706587003969 Prephenate dehydratase; Region: PDT; pfam00800 706587003970 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 706587003971 putative L-Phe binding site [chemical binding]; other site 706587003972 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 706587003973 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 706587003974 Prephenate dehydrogenase; Region: PDH; pfam02153 706587003975 prephenate dehydrogenase; Validated; Region: PRK08507 706587003976 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 706587003977 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 706587003978 hinge; other site 706587003979 active site 706587003980 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 706587003981 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 706587003982 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 706587003983 shikimate binding site; other site 706587003984 NAD(P) binding site [chemical binding]; other site 706587003985 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 706587003986 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 706587003987 Tetramer interface [polypeptide binding]; other site 706587003988 active site 706587003989 FMN-binding site [chemical binding]; other site 706587003990 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 706587003991 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 706587003992 ADP binding site [chemical binding]; other site 706587003993 magnesium binding site [ion binding]; other site 706587003994 putative shikimate binding site; other site 706587003995 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 706587003996 active site 706587003997 dimer interface [polypeptide binding]; other site 706587003998 metal binding site [ion binding]; metal-binding site 706587003999 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 706587004000 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706587004001 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587004002 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587004003 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 706587004004 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587004005 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 706587004006 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 706587004007 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 706587004008 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 706587004009 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 706587004010 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 706587004011 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 706587004012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 706587004013 hypothetical protein; Reviewed; Region: PRK12497 706587004014 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 706587004015 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587004016 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587004017 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 706587004018 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 706587004019 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 706587004020 E3 interaction surface; other site 706587004021 lipoyl attachment site [posttranslational modification]; other site 706587004022 e3 binding domain; Region: E3_binding; pfam02817 706587004023 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 706587004024 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 706587004025 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 706587004026 alpha subunit interface [polypeptide binding]; other site 706587004027 TPP binding site [chemical binding]; other site 706587004028 heterodimer interface [polypeptide binding]; other site 706587004029 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706587004030 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 706587004031 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 706587004032 TPP-binding site [chemical binding]; other site 706587004033 tetramer interface [polypeptide binding]; other site 706587004034 heterodimer interface [polypeptide binding]; other site 706587004035 phosphorylation loop region [posttranslational modification] 706587004036 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 706587004037 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 706587004038 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 706587004039 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587004040 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 706587004041 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 706587004042 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 706587004043 active site 706587004044 catalytic site [active] 706587004045 phosphoglycolate phosphatase; Provisional; Region: PRK13222 706587004046 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587004047 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 706587004048 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 706587004049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 706587004050 binding surface 706587004051 TPR motif; other site 706587004052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587004053 binding surface 706587004054 TPR motif; other site 706587004055 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 706587004056 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 706587004057 N-acetyl-D-glucosamine binding site [chemical binding]; other site 706587004058 catalytic residue [active] 706587004059 Domain of unknown function (DUF955); Region: DUF955; pfam06114 706587004060 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 706587004061 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 706587004062 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 706587004063 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 706587004064 dimer interface [polypeptide binding]; other site 706587004065 PYR/PP interface [polypeptide binding]; other site 706587004066 TPP binding site [chemical binding]; other site 706587004067 substrate binding site [chemical binding]; other site 706587004068 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706587004069 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 706587004070 TPP-binding site; other site 706587004071 4Fe-4S binding domain; Region: Fer4; pfam00037 706587004072 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 706587004073 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 706587004074 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 706587004075 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 706587004076 active site 706587004077 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 706587004078 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587004079 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587004080 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587004081 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587004082 TM-ABC transporter signature motif; other site 706587004083 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587004084 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587004085 TM-ABC transporter signature motif; other site 706587004086 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 706587004087 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 706587004088 acyl-activating enzyme (AAE) consensus motif; other site 706587004089 putative AMP binding site [chemical binding]; other site 706587004090 putative active site [active] 706587004091 putative CoA binding site [chemical binding]; other site 706587004092 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587004093 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587004094 Walker A/P-loop; other site 706587004095 ATP binding site [chemical binding]; other site 706587004096 Q-loop/lid; other site 706587004097 ABC transporter signature motif; other site 706587004098 Walker B; other site 706587004099 D-loop; other site 706587004100 H-loop/switch region; other site 706587004101 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587004102 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587004103 Walker A/P-loop; other site 706587004104 ATP binding site [chemical binding]; other site 706587004105 Q-loop/lid; other site 706587004106 ABC transporter signature motif; other site 706587004107 Walker B; other site 706587004108 D-loop; other site 706587004109 H-loop/switch region; other site 706587004110 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587004111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587004112 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587004113 putative acyltransferase; Provisional; Region: PRK05790 706587004114 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 706587004115 dimer interface [polypeptide binding]; other site 706587004116 active site 706587004117 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 706587004118 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587004119 active site 706587004120 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 706587004121 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 706587004122 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 706587004123 intrachain domain interface; other site 706587004124 interchain domain interface [polypeptide binding]; other site 706587004125 heme bH binding site [chemical binding]; other site 706587004126 Qi binding site; other site 706587004127 heme bL binding site [chemical binding]; other site 706587004128 Qo binding site; other site 706587004129 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 706587004130 iron-sulfur cluster [ion binding]; other site 706587004131 [2Fe-2S] cluster binding site [ion binding]; other site 706587004132 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 706587004133 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 706587004134 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 706587004135 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 706587004136 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587004137 thiosulfate reductase PhsA; Provisional; Region: PRK15488 706587004138 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 706587004139 putative [Fe4-S4] binding site [ion binding]; other site 706587004140 putative molybdopterin cofactor binding site [chemical binding]; other site 706587004141 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 706587004142 putative molybdopterin cofactor binding site; other site 706587004143 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 706587004144 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 706587004145 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587004146 salt bridge; other site 706587004147 non-specific DNA binding site [nucleotide binding]; other site 706587004148 sequence-specific DNA binding site [nucleotide binding]; other site 706587004149 thiamine monophosphate kinase; Provisional; Region: PRK05731 706587004150 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 706587004151 ATP binding site [chemical binding]; other site 706587004152 dimerization interface [polypeptide binding]; other site 706587004153 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 706587004154 putative acyl-acceptor binding pocket; other site 706587004155 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 706587004156 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 706587004157 phosphopeptide binding site; other site 706587004158 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706587004159 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 706587004160 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 706587004161 cyclase homology domain; Region: CHD; cd07302 706587004162 nucleotidyl binding site; other site 706587004163 metal binding site [ion binding]; metal-binding site 706587004164 dimer interface [polypeptide binding]; other site 706587004165 PilZ domain; Region: PilZ; pfam07238 706587004166 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 706587004167 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 706587004168 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 706587004169 G1 box; other site 706587004170 GTP/Mg2+ binding site [chemical binding]; other site 706587004171 G2 box; other site 706587004172 Switch I region; other site 706587004173 G3 box; other site 706587004174 Switch II region; other site 706587004175 G4 box; other site 706587004176 G5 box; other site 706587004177 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 706587004178 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 706587004179 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 706587004180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587004181 binding surface 706587004182 TPR repeat; Region: TPR_11; pfam13414 706587004183 TPR motif; other site 706587004184 TPR repeat; Region: TPR_11; pfam13414 706587004185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587004186 binding surface 706587004187 TPR motif; other site 706587004188 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587004189 PAS domain; Region: PAS_9; pfam13426 706587004190 putative active site [active] 706587004191 heme pocket [chemical binding]; other site 706587004192 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587004193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587004194 putative active site [active] 706587004195 heme pocket [chemical binding]; other site 706587004196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587004197 dimer interface [polypeptide binding]; other site 706587004198 phosphorylation site [posttranslational modification] 706587004199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587004200 ATP binding site [chemical binding]; other site 706587004201 Mg2+ binding site [ion binding]; other site 706587004202 G-X-G motif; other site 706587004203 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 706587004204 nucleotide binding site/active site [active] 706587004205 HIT family signature motif; other site 706587004206 catalytic residue [active] 706587004207 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 706587004208 nucleotide binding site/active site [active] 706587004209 HIT family signature motif; other site 706587004210 catalytic residue [active] 706587004211 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587004212 dimerization interface [polypeptide binding]; other site 706587004213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587004214 PAS domain; Region: PAS_9; pfam13426 706587004215 putative active site [active] 706587004216 heme pocket [chemical binding]; other site 706587004217 PAS domain S-box; Region: sensory_box; TIGR00229 706587004218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587004219 putative active site [active] 706587004220 heme pocket [chemical binding]; other site 706587004221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587004222 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587004223 putative active site [active] 706587004224 heme pocket [chemical binding]; other site 706587004225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587004226 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587004227 putative active site [active] 706587004228 heme pocket [chemical binding]; other site 706587004229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587004230 dimer interface [polypeptide binding]; other site 706587004231 phosphorylation site [posttranslational modification] 706587004232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587004233 ATP binding site [chemical binding]; other site 706587004234 Mg2+ binding site [ion binding]; other site 706587004235 G-X-G motif; other site 706587004236 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587004237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587004238 active site 706587004239 phosphorylation site [posttranslational modification] 706587004240 intermolecular recognition site; other site 706587004241 dimerization interface [polypeptide binding]; other site 706587004242 Ycf46; Provisional; Region: ycf46; CHL00195 706587004243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587004244 Walker A motif; other site 706587004245 ATP binding site [chemical binding]; other site 706587004246 Walker B motif; other site 706587004247 arginine finger; other site 706587004248 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 706587004249 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706587004250 Walker A/P-loop; other site 706587004251 ATP binding site [chemical binding]; other site 706587004252 Q-loop/lid; other site 706587004253 ABC transporter signature motif; other site 706587004254 Walker B; other site 706587004255 D-loop; other site 706587004256 H-loop/switch region; other site 706587004257 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 706587004258 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 706587004259 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 706587004260 putative active site [active] 706587004261 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 706587004262 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587004263 4Fe-4S binding domain; Region: Fer4; pfam00037 706587004264 reductive dehalogenase; Region: RDH; TIGR02486 706587004265 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 706587004266 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587004267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587004268 Walker A motif; other site 706587004269 ATP binding site [chemical binding]; other site 706587004270 Walker B motif; other site 706587004271 arginine finger; other site 706587004272 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587004273 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 706587004274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587004275 ATP binding site [chemical binding]; other site 706587004276 Mg2+ binding site [ion binding]; other site 706587004277 G-X-G motif; other site 706587004278 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 706587004279 ATP binding site [chemical binding]; other site 706587004280 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 706587004281 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 706587004282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587004283 Walker A motif; other site 706587004284 ATP binding site [chemical binding]; other site 706587004285 Walker B motif; other site 706587004286 arginine finger; other site 706587004287 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 706587004288 hypothetical protein; Validated; Region: PRK00110 706587004289 PilZ domain; Region: PilZ; pfam07238 706587004290 aminopeptidase N, Escherichia coli type; Region: pepN_proteo; TIGR02414 706587004291 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 706587004292 Zn binding site [ion binding]; other site 706587004293 Staphylococcal nuclease homologues; Region: SNc; smart00318 706587004294 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 706587004295 Catalytic site; other site 706587004296 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 706587004297 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 706587004298 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 706587004299 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 706587004300 dimerization interface [polypeptide binding]; other site 706587004301 ATP binding site [chemical binding]; other site 706587004302 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 706587004303 dimerization interface [polypeptide binding]; other site 706587004304 ATP binding site [chemical binding]; other site 706587004305 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 706587004306 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 706587004307 active site 706587004308 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 706587004309 CoA binding domain; Region: CoA_binding_2; pfam13380 706587004310 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 706587004311 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 706587004312 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 706587004313 RuvA N terminal domain; Region: RuvA_N; pfam01330 706587004314 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 706587004315 active site 706587004316 putative DNA-binding cleft [nucleotide binding]; other site 706587004317 dimer interface [polypeptide binding]; other site 706587004318 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587004319 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587004320 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 706587004321 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706587004322 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587004323 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 706587004324 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 706587004325 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 706587004326 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 706587004327 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 706587004328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587004329 Walker A motif; other site 706587004330 ATP binding site [chemical binding]; other site 706587004331 Walker B motif; other site 706587004332 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 706587004333 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587004334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587004335 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587004336 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 706587004337 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 706587004338 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 706587004339 dimer interface [polypeptide binding]; other site 706587004340 PYR/PP interface [polypeptide binding]; other site 706587004341 TPP binding site [chemical binding]; other site 706587004342 substrate binding site [chemical binding]; other site 706587004343 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 706587004344 TPP-binding site; other site 706587004345 4Fe-4S binding domain; Region: Fer4; pfam00037 706587004346 HEAT repeats; Region: HEAT_2; pfam13646 706587004347 Flagellin N-methylase; Region: FliB; pfam03692 706587004348 SEC-C motif; Region: SEC-C; pfam02810 706587004349 TPR repeat; Region: TPR_11; pfam13414 706587004350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587004351 binding surface 706587004352 TPR motif; other site 706587004353 TPR repeat; Region: TPR_11; pfam13414 706587004354 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 706587004355 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 706587004356 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 706587004357 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 706587004358 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 706587004359 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 706587004360 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587004361 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 706587004362 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587004363 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 706587004364 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 706587004365 tricarballylate utilization protein B; Provisional; Region: PRK15033 706587004366 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 706587004367 DsrE/DsrF-like family; Region: DrsE; cl00672 706587004368 adenylosuccinate lyase; Provisional; Region: PRK07492 706587004369 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 706587004370 tetramer interface [polypeptide binding]; other site 706587004371 active site 706587004372 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 706587004373 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 706587004374 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 706587004375 active site 706587004376 Zn binding site [ion binding]; other site 706587004377 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 706587004378 tetramerization interface [polypeptide binding]; other site 706587004379 active site 706587004380 pantoate--beta-alanine ligase; Region: panC; TIGR00018 706587004381 Pantoate-beta-alanine ligase; Region: PanC; cd00560 706587004382 active site 706587004383 ATP-binding site [chemical binding]; other site 706587004384 pantoate-binding site; other site 706587004385 HXXH motif; other site 706587004386 Uncharacterized conserved protein [Function unknown]; Region: COG2006 706587004387 Domain of unknown function (DUF362); Region: DUF362; pfam04015 706587004388 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 706587004389 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 706587004390 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 706587004391 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 706587004392 catalytic triad [active] 706587004393 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 706587004394 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 706587004395 acyl-activating enzyme (AAE) consensus motif; other site 706587004396 putative AMP binding site [chemical binding]; other site 706587004397 putative active site [active] 706587004398 putative CoA binding site [chemical binding]; other site 706587004399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587004400 dimer interface [polypeptide binding]; other site 706587004401 phosphorylation site [posttranslational modification] 706587004402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587004403 ATP binding site [chemical binding]; other site 706587004404 Mg2+ binding site [ion binding]; other site 706587004405 G-X-G motif; other site 706587004406 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587004407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587004408 active site 706587004409 phosphorylation site [posttranslational modification] 706587004410 intermolecular recognition site; other site 706587004411 dimerization interface [polypeptide binding]; other site 706587004412 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 706587004413 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 706587004414 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 706587004415 lipoyl attachment site [posttranslational modification]; other site 706587004416 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 706587004417 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 706587004418 tetramer interface [polypeptide binding]; other site 706587004419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587004420 catalytic residue [active] 706587004421 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 706587004422 tetramer interface [polypeptide binding]; other site 706587004423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587004424 catalytic residue [active] 706587004425 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 706587004426 EamA-like transporter family; Region: EamA; pfam00892 706587004427 Putative Fe-S cluster; Region: FeS; cl17515 706587004428 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 706587004429 Cyclophilin-like; Region: Cyclophil_like; pfam04126 706587004430 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 706587004431 Interdomain contacts; other site 706587004432 Cytokine receptor motif; other site 706587004433 TPR repeat; Region: TPR_11; pfam13414 706587004434 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587004435 TPR motif; other site 706587004436 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 706587004437 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 706587004438 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 706587004439 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 706587004440 4Fe-4S binding domain; Region: Fer4; cl02805 706587004441 Ferredoxin [Energy production and conversion]; Region: COG1146 706587004442 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 706587004443 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 706587004444 active site 706587004445 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 706587004446 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 706587004447 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase; Region: dearomat_oah; TIGR03200 706587004448 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587004449 substrate binding site [chemical binding]; other site 706587004450 oxyanion hole (OAH) forming residues; other site 706587004451 trimer interface [polypeptide binding]; other site 706587004452 cyclohexa-1,5-dienecarbonyl-CoA hydratase; Region: dienoyl_CoA_hyt; TIGR03189 706587004453 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587004454 substrate binding site [chemical binding]; other site 706587004455 oxyanion hole (OAH) forming residues; other site 706587004456 trimer interface [polypeptide binding]; other site 706587004457 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 706587004458 Phosphotransferase enzyme family; Region: APH; pfam01636 706587004459 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 706587004460 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 706587004461 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 706587004462 active site 706587004463 Substrate binding site; other site 706587004464 Mg++ binding site; other site 706587004465 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 706587004466 putative trimer interface [polypeptide binding]; other site 706587004467 putative CoA binding site [chemical binding]; other site 706587004468 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 706587004469 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 706587004470 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 706587004471 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 706587004472 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 706587004473 PGAP1-like protein; Region: PGAP1; pfam07819 706587004474 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 706587004475 von Willebrand factor type A domain; Region: VWA_2; pfam13519 706587004476 metal ion-dependent adhesion site (MIDAS); other site 706587004477 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 706587004478 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 706587004479 ligand binding site [chemical binding]; other site 706587004480 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 706587004481 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 706587004482 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 706587004483 substrate binding pocket [chemical binding]; other site 706587004484 chain length determination region; other site 706587004485 substrate-Mg2+ binding site; other site 706587004486 catalytic residues [active] 706587004487 aspartate-rich region 1; other site 706587004488 active site lid residues [active] 706587004489 aspartate-rich region 2; other site 706587004490 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 706587004491 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 706587004492 TPP-binding site; other site 706587004493 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 706587004494 PYR/PP interface [polypeptide binding]; other site 706587004495 dimer interface [polypeptide binding]; other site 706587004496 TPP binding site [chemical binding]; other site 706587004497 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706587004498 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706587004499 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 706587004500 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587004501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 706587004502 dimer interface [polypeptide binding]; other site 706587004503 phosphorylation site [posttranslational modification] 706587004504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587004505 ATP binding site [chemical binding]; other site 706587004506 Mg2+ binding site [ion binding]; other site 706587004507 G-X-G motif; other site 706587004508 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587004509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587004510 active site 706587004511 phosphorylation site [posttranslational modification] 706587004512 intermolecular recognition site; other site 706587004513 dimerization interface [polypeptide binding]; other site 706587004514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587004515 Walker A motif; other site 706587004516 ATP binding site [chemical binding]; other site 706587004517 Walker B motif; other site 706587004518 arginine finger; other site 706587004519 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587004520 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587004521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587004522 putative active site [active] 706587004523 heme pocket [chemical binding]; other site 706587004524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587004525 dimer interface [polypeptide binding]; other site 706587004526 phosphorylation site [posttranslational modification] 706587004527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587004528 ATP binding site [chemical binding]; other site 706587004529 Mg2+ binding site [ion binding]; other site 706587004530 G-X-G motif; other site 706587004531 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 706587004532 YceG-like family; Region: YceG; pfam02618 706587004533 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 706587004534 dimerization interface [polypeptide binding]; other site 706587004535 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 706587004536 Protein export membrane protein; Region: SecD_SecF; cl14618 706587004537 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 706587004538 PAS domain; Region: PAS_9; pfam13426 706587004539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587004540 putative active site [active] 706587004541 heme pocket [chemical binding]; other site 706587004542 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587004543 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587004544 putative active site [active] 706587004545 heme pocket [chemical binding]; other site 706587004546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587004547 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587004548 putative active site [active] 706587004549 heme pocket [chemical binding]; other site 706587004550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587004551 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587004552 putative active site [active] 706587004553 heme pocket [chemical binding]; other site 706587004554 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587004555 putative active site [active] 706587004556 heme pocket [chemical binding]; other site 706587004557 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706587004558 GAF domain; Region: GAF; pfam01590 706587004559 PAS domain S-box; Region: sensory_box; TIGR00229 706587004560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587004561 putative active site [active] 706587004562 heme pocket [chemical binding]; other site 706587004563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587004564 dimer interface [polypeptide binding]; other site 706587004565 phosphorylation site [posttranslational modification] 706587004566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587004567 ATP binding site [chemical binding]; other site 706587004568 Mg2+ binding site [ion binding]; other site 706587004569 G-X-G motif; other site 706587004570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587004571 FeS/SAM binding site; other site 706587004572 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 706587004573 Caspase domain; Region: Peptidase_C14; pfam00656 706587004574 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587004575 Ankyrin repeat; Region: Ank; pfam00023 706587004576 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587004577 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587004578 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587004579 Ankyrin repeat; Region: Ank; pfam00023 706587004580 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587004581 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587004582 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587004583 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587004584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587004585 muropeptide transporter; Reviewed; Region: ampG; PRK11902 706587004586 putative substrate translocation pore; other site 706587004587 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 706587004588 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706587004589 HEAT repeats; Region: HEAT_2; pfam13646 706587004590 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 706587004591 HEAT repeats; Region: HEAT_2; pfam13646 706587004592 Fic family protein [Function unknown]; Region: COG3177 706587004593 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 706587004594 Fic/DOC family; Region: Fic; pfam02661 706587004595 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 706587004596 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 706587004597 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 706587004598 phosphate binding site [ion binding]; other site 706587004599 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 706587004600 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 706587004601 active site 706587004602 Acyl transferase domain; Region: Acyl_transf_1; cl08282 706587004603 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 706587004604 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 706587004605 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 706587004606 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 706587004607 active site 706587004608 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 706587004609 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 706587004610 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 706587004611 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 706587004612 putative NADP binding site [chemical binding]; other site 706587004613 active site 706587004614 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 706587004615 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 706587004616 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 706587004617 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587004618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587004619 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 706587004620 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706587004621 dimerization interface [polypeptide binding]; other site 706587004622 putative DNA binding site [nucleotide binding]; other site 706587004623 putative Zn2+ binding site [ion binding]; other site 706587004624 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 706587004625 Methyltransferase domain; Region: Methyltransf_31; pfam13847 706587004626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587004627 S-adenosylmethionine binding site [chemical binding]; other site 706587004628 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 706587004629 putative ADP-binding pocket [chemical binding]; other site 706587004630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587004631 TPR motif; other site 706587004632 binding surface 706587004633 TPR repeat; Region: TPR_11; pfam13414 706587004634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587004635 TPR motif; other site 706587004636 TPR repeat; Region: TPR_11; pfam13414 706587004637 binding surface 706587004638 enoyl-CoA hydratase; Validated; Region: PRK08139 706587004639 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587004640 substrate binding site [chemical binding]; other site 706587004641 oxyanion hole (OAH) forming residues; other site 706587004642 trimer interface [polypeptide binding]; other site 706587004643 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 706587004644 TrkA-N domain; Region: TrkA_N; pfam02254 706587004645 TrkA-C domain; Region: TrkA_C; pfam02080 706587004646 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 706587004647 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 706587004648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587004649 putative substrate translocation pore; other site 706587004650 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706587004651 PilZ domain; Region: PilZ; pfam07238 706587004652 PilZ domain; Region: PilZ; pfam07238 706587004653 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 706587004654 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 706587004655 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 706587004656 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 706587004657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587004658 Coenzyme A binding pocket [chemical binding]; other site 706587004659 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 706587004660 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 706587004661 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 706587004662 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 706587004663 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 706587004664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587004665 FeS/SAM binding site; other site 706587004666 HemN C-terminal domain; Region: HemN_C; pfam06969 706587004667 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706587004668 GAF domain; Region: GAF; pfam01590 706587004669 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 706587004670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587004671 dimer interface [polypeptide binding]; other site 706587004672 phosphorylation site [posttranslational modification] 706587004673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587004674 ATP binding site [chemical binding]; other site 706587004675 Mg2+ binding site [ion binding]; other site 706587004676 G-X-G motif; other site 706587004677 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 706587004678 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587004679 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587004680 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587004681 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 706587004682 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706587004683 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706587004684 DNA binding residues [nucleotide binding] 706587004685 Putative zinc-finger; Region: zf-HC2; pfam13490 706587004686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587004687 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706587004688 putative substrate translocation pore; other site 706587004689 Uncharacterized conserved protein [Function unknown]; Region: COG1262 706587004690 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 706587004691 TPR repeat; Region: TPR_11; pfam13414 706587004692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 706587004693 binding surface 706587004694 TPR motif; other site 706587004695 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 706587004696 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 706587004697 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 706587004698 putative ribose interaction site [chemical binding]; other site 706587004699 putative ADP binding site [chemical binding]; other site 706587004700 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 706587004701 active site 706587004702 nucleotide binding site [chemical binding]; other site 706587004703 HIGH motif; other site 706587004704 KMSKS motif; other site 706587004705 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 706587004706 dimer interface [polypeptide binding]; other site 706587004707 phosphomethylpyrimidine kinase; Provisional; Region: PRK08573 706587004708 substrate binding site [chemical binding]; other site 706587004709 ATP binding site [chemical binding]; other site 706587004710 Putative aldolase; Region: Aldolase_2; pfam10120 706587004711 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 706587004712 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587004713 FeS/SAM binding site; other site 706587004714 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 706587004715 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 706587004716 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 706587004717 Probable Catalytic site; other site 706587004718 metal-binding site 706587004719 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 706587004720 ribonuclease G; Provisional; Region: PRK11712 706587004721 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 706587004722 homodimer interface [polypeptide binding]; other site 706587004723 oligonucleotide binding site [chemical binding]; other site 706587004724 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 706587004725 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 706587004726 B12 binding site [chemical binding]; other site 706587004727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587004728 FeS/SAM binding site; other site 706587004729 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 706587004730 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 706587004731 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 706587004732 CoA binding domain; Region: CoA_binding_2; pfam13380 706587004733 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 706587004734 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587004735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587004736 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 706587004737 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587004738 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 706587004739 substrate binding site [chemical binding]; other site 706587004740 oxyanion hole (OAH) forming residues; other site 706587004741 trimer interface [polypeptide binding]; other site 706587004742 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587004743 Nucleopolyhedrovirus P10 protein; Region: NPV_P10; cl17484 706587004744 Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679 706587004745 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 706587004746 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 706587004747 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 706587004748 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 706587004749 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 706587004750 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587004751 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 706587004752 catalytic triad [active] 706587004753 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 706587004754 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 706587004755 active site 706587004756 catalytic triad [active] 706587004757 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cl00505 706587004758 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 706587004759 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 706587004760 ATP binding site [chemical binding]; other site 706587004761 Mg2+ binding site [ion binding]; other site 706587004762 G-X-G motif; other site 706587004763 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 706587004764 anti sigma factor interaction site; other site 706587004765 regulatory phosphorylation site [posttranslational modification]; other site 706587004766 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 706587004767 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 706587004768 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 706587004769 spermidine synthase; Provisional; Region: PRK03612 706587004770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587004771 S-adenosylmethionine binding site [chemical binding]; other site 706587004772 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 706587004773 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 706587004774 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 706587004775 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 706587004776 pyrroline-5-carboxylate reductase; Region: PLN02688 706587004777 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 706587004778 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 706587004779 CPxP motif; other site 706587004780 DsrE/DsrF-like family; Region: DrsE; pfam02635 706587004781 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 706587004782 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 706587004783 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 706587004784 nucleotide binding site [chemical binding]; other site 706587004785 NEF interaction site [polypeptide binding]; other site 706587004786 SBD interface [polypeptide binding]; other site 706587004787 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 706587004788 CoA-transferase family III; Region: CoA_transf_3; pfam02515 706587004789 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 706587004790 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587004791 active site 706587004792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587004793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587004794 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 706587004795 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587004796 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 706587004797 substrate binding site [chemical binding]; other site 706587004798 oxyanion hole (OAH) forming residues; other site 706587004799 trimer interface [polypeptide binding]; other site 706587004800 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 706587004801 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 706587004802 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 706587004803 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 706587004804 dimer interface [polypeptide binding]; other site 706587004805 active site 706587004806 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 706587004807 homodimer interaction site [polypeptide binding]; other site 706587004808 cofactor binding site; other site 706587004809 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587004810 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 706587004811 FtsX-like permease family; Region: FtsX; pfam02687 706587004812 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 706587004813 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 706587004814 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 706587004815 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587004816 Zn2+ binding site [ion binding]; other site 706587004817 Mg2+ binding site [ion binding]; other site 706587004818 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 706587004819 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 706587004820 Rdx family; Region: Rdx; pfam10262 706587004821 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 706587004822 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 706587004823 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 706587004824 DNA methylase; Region: N6_N4_Mtase; pfam01555 706587004825 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587004826 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 706587004827 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 706587004828 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 706587004829 active site 706587004830 catalytic triad [active] 706587004831 oxyanion hole [active] 706587004832 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587004833 Cysteine-rich domain; Region: CCG; pfam02754 706587004834 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 706587004835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587004836 S-adenosylmethionine binding site [chemical binding]; other site 706587004837 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 706587004838 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587004839 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587004840 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 706587004841 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 706587004842 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 706587004843 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 706587004844 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 706587004845 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 706587004846 active site 706587004847 dimer interface [polypeptide binding]; other site 706587004848 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 706587004849 Ligand Binding Site [chemical binding]; other site 706587004850 Molecular Tunnel; other site 706587004851 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 706587004852 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587004853 putative active site [active] 706587004854 heme pocket [chemical binding]; other site 706587004855 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587004856 putative active site [active] 706587004857 heme pocket [chemical binding]; other site 706587004858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587004859 Walker A motif; other site 706587004860 ATP binding site [chemical binding]; other site 706587004861 Walker B motif; other site 706587004862 arginine finger; other site 706587004863 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 706587004864 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587004865 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 706587004866 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 706587004867 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 706587004868 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 706587004869 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587004870 rod shape-determining protein MreB; Provisional; Region: PRK13927 706587004871 MreB and similar proteins; Region: MreB_like; cd10225 706587004872 nucleotide binding site [chemical binding]; other site 706587004873 Mg binding site [ion binding]; other site 706587004874 putative protofilament interaction site [polypeptide binding]; other site 706587004875 RodZ interaction site [polypeptide binding]; other site 706587004876 SurA N-terminal domain; Region: SurA_N; pfam09312 706587004877 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 706587004878 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 706587004879 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 706587004880 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706587004881 ATP binding site [chemical binding]; other site 706587004882 putative Mg++ binding site [ion binding]; other site 706587004883 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706587004884 nucleotide binding region [chemical binding]; other site 706587004885 ATP-binding site [chemical binding]; other site 706587004886 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 706587004887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587004888 binding surface 706587004889 TPR motif; other site 706587004890 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587004891 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 706587004892 IHF dimer interface [polypeptide binding]; other site 706587004893 IHF - DNA interface [nucleotide binding]; other site 706587004894 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 706587004895 dimer interface [polypeptide binding]; other site 706587004896 Putative zinc-finger; Region: zf-HC2; pfam13490 706587004897 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 706587004898 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706587004899 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706587004900 DNA binding residues [nucleotide binding] 706587004901 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 706587004902 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706587004903 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706587004904 DNA binding residues [nucleotide binding] 706587004905 AAA domain; Region: AAA_32; pfam13654 706587004906 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 706587004907 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 706587004908 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 706587004909 dimer interface [polypeptide binding]; other site 706587004910 active site 706587004911 RNB domain; Region: RNB; pfam00773 706587004912 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 706587004913 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 706587004914 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 706587004915 active site 706587004916 ATP binding site [chemical binding]; other site 706587004917 substrate binding site [chemical binding]; other site 706587004918 activation loop (A-loop); other site 706587004919 TPR repeat; Region: TPR_11; pfam13414 706587004920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587004921 binding surface 706587004922 TPR motif; other site 706587004923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587004924 binding surface 706587004925 TPR motif; other site 706587004926 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587004927 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 706587004928 structural tetrad; other site 706587004929 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 706587004930 structural tetrad; other site 706587004931 FOG: WD40 repeat [General function prediction only]; Region: COG2319 706587004932 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 706587004933 structural tetrad; other site 706587004934 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 706587004935 putative active site [active] 706587004936 putative CoA binding site [chemical binding]; other site 706587004937 nudix motif; other site 706587004938 metal binding site [ion binding]; metal-binding site 706587004939 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 706587004940 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 706587004941 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587004942 Family description; Region: VCBS; pfam13517 706587004943 Predicted ATPase [General function prediction only]; Region: COG4637 706587004944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587004945 Walker A/P-loop; other site 706587004946 ATP binding site [chemical binding]; other site 706587004947 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 706587004948 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 706587004949 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 706587004950 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587004951 dimerization interface [polypeptide binding]; other site 706587004952 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 706587004953 cyclase homology domain; Region: CHD; cd07302 706587004954 nucleotidyl binding site; other site 706587004955 metal binding site [ion binding]; metal-binding site 706587004956 dimer interface [polypeptide binding]; other site 706587004957 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 706587004958 putative FMN binding site [chemical binding]; other site 706587004959 NADPH bind site [chemical binding]; other site 706587004960 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 706587004961 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 706587004962 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 706587004963 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587004964 active site 706587004965 acetyl-CoA acetyltransferase; Validated; Region: PRK06157 706587004966 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 706587004967 active site 706587004968 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 706587004969 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 706587004970 dimer interface [polypeptide binding]; other site 706587004971 active site 706587004972 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 706587004973 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 706587004974 DUF35 OB-fold domain; Region: DUF35; pfam01796 706587004975 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 706587004976 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 706587004977 NAD binding site [chemical binding]; other site 706587004978 homodimer interface [polypeptide binding]; other site 706587004979 active site 706587004980 SCP-2 sterol transfer family; Region: SCP2; pfam02036 706587004981 enoyl-CoA hydratase; Region: PLN02864 706587004982 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 706587004983 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 706587004984 dimer interaction site [polypeptide binding]; other site 706587004985 substrate-binding tunnel; other site 706587004986 active site 706587004987 catalytic site [active] 706587004988 substrate binding site [chemical binding]; other site 706587004989 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 706587004990 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 706587004991 NAD binding site [chemical binding]; other site 706587004992 homodimer interface [polypeptide binding]; other site 706587004993 active site 706587004994 SCP-2 sterol transfer family; Region: SCP2; pfam02036 706587004995 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 706587004996 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 706587004997 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 706587004998 catalytic triad [active] 706587004999 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 706587005000 DEAD/DEAH box helicase; Region: DEAD; pfam00270 706587005001 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 706587005002 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 706587005003 anti sigma factor interaction site; other site 706587005004 regulatory phosphorylation site [posttranslational modification]; other site 706587005005 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 706587005006 Permease; Region: Permease; pfam02405 706587005007 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 706587005008 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 706587005009 Walker A/P-loop; other site 706587005010 ATP binding site [chemical binding]; other site 706587005011 Q-loop/lid; other site 706587005012 ABC transporter signature motif; other site 706587005013 Walker B; other site 706587005014 D-loop; other site 706587005015 H-loop/switch region; other site 706587005016 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 706587005017 mce related protein; Region: MCE; pfam02470 706587005018 Protein of unknown function (DUF330); Region: DUF330; cl01135 706587005019 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587005020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005021 active site 706587005022 phosphorylation site [posttranslational modification] 706587005023 intermolecular recognition site; other site 706587005024 dimerization interface [polypeptide binding]; other site 706587005025 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 706587005026 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 706587005027 ligand binding site; other site 706587005028 oligomer interface; other site 706587005029 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 706587005030 dimer interface [polypeptide binding]; other site 706587005031 N-terminal domain interface [polypeptide binding]; other site 706587005032 sulfate 1 binding site; other site 706587005033 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 706587005034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587005035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587005036 FOG: CBS domain [General function prediction only]; Region: COG0517 706587005037 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 706587005038 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 706587005039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587005040 dimer interface [polypeptide binding]; other site 706587005041 phosphorylation site [posttranslational modification] 706587005042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587005043 ATP binding site [chemical binding]; other site 706587005044 Mg2+ binding site [ion binding]; other site 706587005045 G-X-G motif; other site 706587005046 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587005047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005048 active site 706587005049 phosphorylation site [posttranslational modification] 706587005050 intermolecular recognition site; other site 706587005051 dimerization interface [polypeptide binding]; other site 706587005052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587005053 Walker A motif; other site 706587005054 ATP binding site [chemical binding]; other site 706587005055 Walker B motif; other site 706587005056 arginine finger; other site 706587005057 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587005058 Transposase IS200 like; Region: Y1_Tnp; pfam01797 706587005059 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 706587005060 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706587005061 ligand binding site [chemical binding]; other site 706587005062 flexible hinge region; other site 706587005063 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587005064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 706587005065 Walker A motif; other site 706587005066 ATP binding site [chemical binding]; other site 706587005067 Walker B motif; other site 706587005068 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 706587005069 4Fe-4S binding domain; Region: Fer4_5; pfam12801 706587005070 4Fe-4S binding domain; Region: Fer4_5; pfam12801 706587005071 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 706587005072 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 706587005073 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 706587005074 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 706587005075 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 706587005076 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 706587005077 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 706587005078 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706587005079 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587005080 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 706587005081 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 706587005082 catalytic residues [active] 706587005083 Putative zinc-finger; Region: zf-HC2; pfam13490 706587005084 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 706587005085 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706587005086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706587005087 DNA binding residues [nucleotide binding] 706587005088 NAD-dependent deacetylase; Provisional; Region: PRK00481 706587005089 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 706587005090 NAD+ binding site [chemical binding]; other site 706587005091 substrate binding site [chemical binding]; other site 706587005092 Zn binding site [ion binding]; other site 706587005093 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 706587005094 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 706587005095 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 706587005096 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 706587005097 putative NAD(P) binding site [chemical binding]; other site 706587005098 catalytic Zn binding site [ion binding]; other site 706587005099 structural Zn binding site [ion binding]; other site 706587005100 Uncharacterized conserved protein [Function unknown]; Region: COG0432 706587005101 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 706587005102 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 706587005103 NADP binding site [chemical binding]; other site 706587005104 homopentamer interface [polypeptide binding]; other site 706587005105 substrate binding site [chemical binding]; other site 706587005106 active site 706587005107 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 706587005108 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 706587005109 dimer interface [polypeptide binding]; other site 706587005110 putative functional site; other site 706587005111 putative MPT binding site; other site 706587005112 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 706587005113 Peptidase family M50; Region: Peptidase_M50; pfam02163 706587005114 active site 706587005115 putative substrate binding region [chemical binding]; other site 706587005116 FOG: CBS domain [General function prediction only]; Region: COG0517 706587005117 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 706587005118 putative carbohydrate kinase; Provisional; Region: PRK10565 706587005119 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 706587005120 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 706587005121 putative substrate binding site [chemical binding]; other site 706587005122 putative ATP binding site [chemical binding]; other site 706587005123 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 706587005124 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 706587005125 XdhC Rossmann domain; Region: XdhC_C; pfam13478 706587005126 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 706587005127 Ligand binding site; other site 706587005128 DXD motif; other site 706587005129 Putative Catalytic site; other site 706587005130 SynChlorMet cassette radical SAM/SPASM protein ScmE; Region: SCM_rSAM_ScmE; TIGR04250 706587005131 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587005132 FeS/SAM binding site; other site 706587005133 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 706587005134 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 706587005135 CoA binding domain; Region: CoA_binding_2; pfam13380 706587005136 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 706587005137 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005138 PAS domain; Region: PAS_9; pfam13426 706587005139 putative active site [active] 706587005140 heme pocket [chemical binding]; other site 706587005141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587005142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587005143 dimer interface [polypeptide binding]; other site 706587005144 phosphorylation site [posttranslational modification] 706587005145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587005146 ATP binding site [chemical binding]; other site 706587005147 Mg2+ binding site [ion binding]; other site 706587005148 G-X-G motif; other site 706587005149 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 706587005150 Methyltransferase domain; Region: Methyltransf_23; pfam13489 706587005151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587005152 S-adenosylmethionine binding site [chemical binding]; other site 706587005153 4-alpha-glucanotransferase; Provisional; Region: PRK14508 706587005154 heat shock protein GrpE; Provisional; Region: PRK14141 706587005155 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 706587005156 dimer interface [polypeptide binding]; other site 706587005157 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 706587005158 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 706587005159 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 706587005160 nucleotide binding site [chemical binding]; other site 706587005161 NEF interaction site [polypeptide binding]; other site 706587005162 SBD interface [polypeptide binding]; other site 706587005163 Uncharacterized conserved protein [Function unknown]; Region: COG4198 706587005164 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 706587005165 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 706587005166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587005167 S-adenosylmethionine binding site [chemical binding]; other site 706587005168 aminotransferase; Validated; Region: PRK08175 706587005169 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706587005170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587005171 homodimer interface [polypeptide binding]; other site 706587005172 catalytic residue [active] 706587005173 homoserine dehydrogenase; Provisional; Region: PRK06349 706587005174 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 706587005175 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 706587005176 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 706587005177 threonine synthase; Reviewed; Region: PRK06721 706587005178 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 706587005179 homodimer interface [polypeptide binding]; other site 706587005180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587005181 catalytic residue [active] 706587005182 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 706587005183 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 706587005184 Transposase IS200 like; Region: Y1_Tnp; cl00848 706587005185 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587005186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587005187 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587005188 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 706587005189 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 706587005190 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 706587005191 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 706587005192 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 706587005193 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 706587005194 active site 706587005195 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 706587005196 dimer interface [polypeptide binding]; other site 706587005197 substrate binding site [chemical binding]; other site 706587005198 catalytic residues [active] 706587005199 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 706587005200 Predicted flavoprotein [General function prediction only]; Region: COG0431 706587005201 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706587005202 Uncharacterized conserved protein [Function unknown]; Region: COG5361 706587005203 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 706587005204 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 706587005205 Smr domain; Region: Smr; pfam01713 706587005206 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587005207 pseudaminic acid synthase; Region: PseI; TIGR03586 706587005208 NeuB family; Region: NeuB; pfam03102 706587005209 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 706587005210 NeuB binding interface [polypeptide binding]; other site 706587005211 putative substrate binding site [chemical binding]; other site 706587005212 WbqC-like protein family; Region: WbqC; pfam08889 706587005213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587005214 FeS/SAM binding site; other site 706587005215 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 706587005216 Response regulator receiver domain; Region: Response_reg; pfam00072 706587005217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005218 active site 706587005219 phosphorylation site [posttranslational modification] 706587005220 intermolecular recognition site; other site 706587005221 dimerization interface [polypeptide binding]; other site 706587005222 PAS domain S-box; Region: sensory_box; TIGR00229 706587005223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005224 putative active site [active] 706587005225 heme pocket [chemical binding]; other site 706587005226 PAS domain; Region: PAS; smart00091 706587005227 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587005228 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005229 putative active site [active] 706587005230 heme pocket [chemical binding]; other site 706587005231 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587005232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005233 putative active site [active] 706587005234 heme pocket [chemical binding]; other site 706587005235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587005236 dimer interface [polypeptide binding]; other site 706587005237 phosphorylation site [posttranslational modification] 706587005238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587005239 ATP binding site [chemical binding]; other site 706587005240 Mg2+ binding site [ion binding]; other site 706587005241 G-X-G motif; other site 706587005242 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 706587005243 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 706587005244 NADP binding site [chemical binding]; other site 706587005245 active site 706587005246 putative substrate binding site [chemical binding]; other site 706587005247 PilZ domain; Region: PilZ; pfam07238 706587005248 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 706587005249 Peptidase family M50; Region: Peptidase_M50; pfam02163 706587005250 active site 706587005251 putative substrate binding region [chemical binding]; other site 706587005252 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 706587005253 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587005254 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 706587005255 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587005256 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587005257 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587005258 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 706587005259 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587005260 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587005261 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587005262 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587005263 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587005264 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 706587005265 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587005266 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587005267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587005268 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706587005269 putative substrate translocation pore; other site 706587005270 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 706587005271 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 706587005272 The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921 706587005273 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 706587005274 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 706587005275 methionine sulfoxide reductase A; Provisional; Region: PRK14054 706587005276 methionine sulfoxide reductase B; Provisional; Region: PRK00222 706587005277 SelR domain; Region: SelR; pfam01641 706587005278 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 706587005279 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 706587005280 putative NAD(P) binding site [chemical binding]; other site 706587005281 putative active site [active] 706587005282 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 706587005283 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706587005284 TIGR04076 family protein; Region: TIGR04076 706587005285 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 706587005286 putative active site pocket [active] 706587005287 dimerization interface [polypeptide binding]; other site 706587005288 putative catalytic residue [active] 706587005289 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 706587005290 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 706587005291 translation initiation factor IF-2; Provisional; Region: PRK14845 706587005292 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 706587005293 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 706587005294 thiosulfate reductase PhsA; Provisional; Region: PRK15488 706587005295 putative [Fe4-S4] binding site [ion binding]; other site 706587005296 putative molybdopterin cofactor binding site [chemical binding]; other site 706587005297 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 706587005298 putative molybdopterin cofactor binding site; other site 706587005299 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 706587005300 Response regulator receiver domain; Region: Response_reg; pfam00072 706587005301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005302 active site 706587005303 phosphorylation site [posttranslational modification] 706587005304 intermolecular recognition site; other site 706587005305 dimerization interface [polypeptide binding]; other site 706587005306 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587005307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005308 active site 706587005309 phosphorylation site [posttranslational modification] 706587005310 intermolecular recognition site; other site 706587005311 dimerization interface [polypeptide binding]; other site 706587005312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587005313 Walker A motif; other site 706587005314 ATP binding site [chemical binding]; other site 706587005315 Walker B motif; other site 706587005316 arginine finger; other site 706587005317 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587005318 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587005319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005320 putative active site [active] 706587005321 heme pocket [chemical binding]; other site 706587005322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587005323 dimer interface [polypeptide binding]; other site 706587005324 phosphorylation site [posttranslational modification] 706587005325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587005326 ATP binding site [chemical binding]; other site 706587005327 Mg2+ binding site [ion binding]; other site 706587005328 G-X-G motif; other site 706587005329 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 706587005330 phosphate binding site [ion binding]; other site 706587005331 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 706587005332 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 706587005333 FAD binding pocket [chemical binding]; other site 706587005334 conserved FAD binding motif [chemical binding]; other site 706587005335 phosphate binding motif [ion binding]; other site 706587005336 beta-alpha-beta structure motif; other site 706587005337 NAD binding pocket [chemical binding]; other site 706587005338 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 706587005339 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 706587005340 Peptidase family M23; Region: Peptidase_M23; pfam01551 706587005341 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 706587005342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587005343 S-adenosylmethionine binding site [chemical binding]; other site 706587005344 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 706587005345 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587005346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005347 active site 706587005348 phosphorylation site [posttranslational modification] 706587005349 intermolecular recognition site; other site 706587005350 dimerization interface [polypeptide binding]; other site 706587005351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587005352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587005353 dimer interface [polypeptide binding]; other site 706587005354 phosphorylation site [posttranslational modification] 706587005355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587005356 ATP binding site [chemical binding]; other site 706587005357 Mg2+ binding site [ion binding]; other site 706587005358 G-X-G motif; other site 706587005359 FeoA domain; Region: FeoA; pfam04023 706587005360 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 706587005361 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 706587005362 G1 box; other site 706587005363 GTP/Mg2+ binding site [chemical binding]; other site 706587005364 Switch I region; other site 706587005365 G2 box; other site 706587005366 G3 box; other site 706587005367 Switch II region; other site 706587005368 G4 box; other site 706587005369 G5 box; other site 706587005370 Nucleoside recognition; Region: Gate; pfam07670 706587005371 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 706587005372 Nucleoside recognition; Region: Gate; pfam07670 706587005373 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 706587005374 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 706587005375 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 706587005376 FeoA domain; Region: FeoA; pfam04023 706587005377 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587005378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005379 active site 706587005380 phosphorylation site [posttranslational modification] 706587005381 intermolecular recognition site; other site 706587005382 dimerization interface [polypeptide binding]; other site 706587005383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587005384 Walker A motif; other site 706587005385 ATP binding site [chemical binding]; other site 706587005386 Walker B motif; other site 706587005387 arginine finger; other site 706587005388 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587005389 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 706587005390 metal ion-dependent adhesion site (MIDAS); other site 706587005391 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 706587005392 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 706587005393 ligand binding site [chemical binding]; other site 706587005394 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 706587005395 B12 binding site [chemical binding]; other site 706587005396 Radical SAM superfamily; Region: Radical_SAM; pfam04055 706587005397 Predicted permeases [General function prediction only]; Region: COG0701 706587005398 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 706587005399 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 706587005400 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 706587005401 putative acyltransferase; Provisional; Region: PRK05790 706587005402 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 706587005403 dimer interface [polypeptide binding]; other site 706587005404 active site 706587005405 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587005406 aconitate hydratase; Validated; Region: PRK07229 706587005407 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 706587005408 substrate binding site [chemical binding]; other site 706587005409 ligand binding site [chemical binding]; other site 706587005410 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 706587005411 substrate binding site [chemical binding]; other site 706587005412 PAS domain S-box; Region: sensory_box; TIGR00229 706587005413 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 706587005414 putative catalytic residues [active] 706587005415 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 706587005416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587005417 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 706587005418 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 706587005419 Na binding site [ion binding]; other site 706587005420 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 706587005421 hypothetical protein; Provisional; Region: PRK08317 706587005422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587005423 S-adenosylmethionine binding site [chemical binding]; other site 706587005424 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 706587005425 active site 706587005426 oxyanion hole [active] 706587005427 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 706587005428 active site residue [active] 706587005429 PAS domain S-box; Region: sensory_box; TIGR00229 706587005430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005431 putative active site [active] 706587005432 heme pocket [chemical binding]; other site 706587005433 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587005434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587005435 dimer interface [polypeptide binding]; other site 706587005436 phosphorylation site [posttranslational modification] 706587005437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587005438 ATP binding site [chemical binding]; other site 706587005439 Mg2+ binding site [ion binding]; other site 706587005440 G-X-G motif; other site 706587005441 Response regulator receiver domain; Region: Response_reg; pfam00072 706587005442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005443 active site 706587005444 phosphorylation site [posttranslational modification] 706587005445 intermolecular recognition site; other site 706587005446 dimerization interface [polypeptide binding]; other site 706587005447 Response regulator receiver domain; Region: Response_reg; pfam00072 706587005448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005449 active site 706587005450 phosphorylation site [posttranslational modification] 706587005451 intermolecular recognition site; other site 706587005452 dimerization interface [polypeptide binding]; other site 706587005453 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 706587005454 putative binding surface; other site 706587005455 active site 706587005456 Response regulator receiver domain; Region: Response_reg; pfam00072 706587005457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005458 active site 706587005459 phosphorylation site [posttranslational modification] 706587005460 intermolecular recognition site; other site 706587005461 dimerization interface [polypeptide binding]; other site 706587005462 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706587005463 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706587005464 metal binding site [ion binding]; metal-binding site 706587005465 active site 706587005466 I-site; other site 706587005467 PilZ domain; Region: PilZ; pfam07238 706587005468 PAS fold; Region: PAS_4; pfam08448 706587005469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005470 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587005471 putative active site [active] 706587005472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 706587005473 dimer interface [polypeptide binding]; other site 706587005474 phosphorylation site [posttranslational modification] 706587005475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587005476 ATP binding site [chemical binding]; other site 706587005477 Mg2+ binding site [ion binding]; other site 706587005478 G-X-G motif; other site 706587005479 Response regulator receiver domain; Region: Response_reg; pfam00072 706587005480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005481 active site 706587005482 phosphorylation site [posttranslational modification] 706587005483 intermolecular recognition site; other site 706587005484 dimerization interface [polypeptide binding]; other site 706587005485 PilZ domain; Region: PilZ; pfam07238 706587005486 Amidohydrolase; Region: Amidohydro_2; pfam04909 706587005487 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 706587005488 catalytic triad [active] 706587005489 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 706587005490 Family description; Region: VCBS; pfam13517 706587005491 Family description; Region: VCBS; pfam13517 706587005492 Family description; Region: VCBS; pfam13517 706587005493 Family description; Region: VCBS; pfam13517 706587005494 Family description; Region: VCBS; pfam13517 706587005495 Family description; Region: VCBS; pfam13517 706587005496 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 706587005497 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 706587005498 Ligand binding site; other site 706587005499 metal-binding site 706587005500 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587005501 Zn2+ binding site [ion binding]; other site 706587005502 Mg2+ binding site [ion binding]; other site 706587005503 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587005504 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 706587005505 acyl-activating enzyme (AAE) consensus motif; other site 706587005506 AMP binding site [chemical binding]; other site 706587005507 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 706587005508 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587005509 FeS/SAM binding site; other site 706587005510 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 706587005511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587005512 S-adenosylmethionine binding site [chemical binding]; other site 706587005513 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587005514 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 706587005515 Cysteine-rich domain; Region: CCG; pfam02754 706587005516 Cysteine-rich domain; Region: CCG; pfam02754 706587005517 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587005518 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 706587005519 catalytic loop [active] 706587005520 iron binding site [ion binding]; other site 706587005521 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587005522 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587005523 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587005524 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 706587005525 Cutinase; Region: Cutinase; pfam01083 706587005526 Protein of unknown function DUF72; Region: DUF72; pfam01904 706587005527 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 706587005528 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 706587005529 [4Fe-4S] binding site [ion binding]; other site 706587005530 molybdopterin cofactor binding site; other site 706587005531 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 706587005532 molybdopterin cofactor binding site; other site 706587005533 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 706587005534 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706587005535 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 706587005536 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 706587005537 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 706587005538 [4Fe-4S] binding site [ion binding]; other site 706587005539 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 706587005540 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 706587005541 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 706587005542 molybdopterin cofactor binding site; other site 706587005543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005544 active site 706587005545 phosphorylation site [posttranslational modification] 706587005546 intermolecular recognition site; other site 706587005547 dimerization interface [polypeptide binding]; other site 706587005548 Transcriptional regulators [Transcription]; Region: FadR; COG2186 706587005549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706587005550 DNA-binding site [nucleotide binding]; DNA binding site 706587005551 FCD domain; Region: FCD; pfam07729 706587005552 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 706587005553 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587005554 acyl-activating enzyme (AAE) consensus motif; other site 706587005555 AMP binding site [chemical binding]; other site 706587005556 active site 706587005557 CoA binding site [chemical binding]; other site 706587005558 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 706587005559 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 706587005560 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 706587005561 DctM-like transporters; Region: DctM; pfam06808 706587005562 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 706587005563 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 706587005564 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587005565 active site 706587005566 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 706587005567 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587005568 catalytic loop [active] 706587005569 iron binding site [ion binding]; other site 706587005570 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587005571 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 706587005572 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 706587005573 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 706587005574 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587005575 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587005576 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 706587005577 putative FMN binding site [chemical binding]; other site 706587005578 NADPH bind site [chemical binding]; other site 706587005579 Transposase IS200 like; Region: Y1_Tnp; pfam01797 706587005580 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 706587005581 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 706587005582 AAA ATPase domain; Region: AAA_16; pfam13191 706587005583 AAA domain; Region: AAA_22; pfam13401 706587005584 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 706587005585 Domain of unknown function DUF87; Region: DUF87; pfam01935 706587005586 AAA-like domain; Region: AAA_10; pfam12846 706587005587 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005588 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587005589 putative active site [active] 706587005590 heme pocket [chemical binding]; other site 706587005591 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005592 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587005593 putative active site [active] 706587005594 heme pocket [chemical binding]; other site 706587005595 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005596 putative active site [active] 706587005597 heme pocket [chemical binding]; other site 706587005598 PAS domain S-box; Region: sensory_box; TIGR00229 706587005599 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005600 putative active site [active] 706587005601 heme pocket [chemical binding]; other site 706587005602 PAS domain; Region: PAS_9; pfam13426 706587005603 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005604 putative active site [active] 706587005605 heme pocket [chemical binding]; other site 706587005606 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587005607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587005608 dimer interface [polypeptide binding]; other site 706587005609 phosphorylation site [posttranslational modification] 706587005610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587005611 ATP binding site [chemical binding]; other site 706587005612 Mg2+ binding site [ion binding]; other site 706587005613 G-X-G motif; other site 706587005614 Response regulator receiver domain; Region: Response_reg; pfam00072 706587005615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005616 active site 706587005617 phosphorylation site [posttranslational modification] 706587005618 intermolecular recognition site; other site 706587005619 dimerization interface [polypeptide binding]; other site 706587005620 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 706587005621 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 706587005622 inhibitor-cofactor binding pocket; inhibition site 706587005623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587005624 catalytic residue [active] 706587005625 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 706587005626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706587005627 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 706587005628 dimer interface [polypeptide binding]; other site 706587005629 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706587005630 substrate binding site [chemical binding]; other site 706587005631 metal binding site [ion binding]; metal-binding site 706587005632 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 706587005633 CoA-transferase family III; Region: CoA_transf_3; pfam02515 706587005634 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 706587005635 Ligand binding site [chemical binding]; other site 706587005636 Electron transfer flavoprotein domain; Region: ETF; pfam01012 706587005637 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587005638 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587005639 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 706587005640 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 706587005641 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 706587005642 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 706587005643 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 706587005644 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587005645 active site 706587005646 Transcriptional regulators [Transcription]; Region: GntR; COG1802 706587005647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706587005648 DNA-binding site [nucleotide binding]; DNA binding site 706587005649 FCD domain; Region: FCD; pfam07729 706587005650 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 706587005651 B12 binding site [chemical binding]; other site 706587005652 cobalt ligand [ion binding]; other site 706587005653 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 706587005654 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 706587005655 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 706587005656 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 706587005657 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 706587005658 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 706587005659 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 706587005660 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587005661 acyl-activating enzyme (AAE) consensus motif; other site 706587005662 AMP binding site [chemical binding]; other site 706587005663 active site 706587005664 CoA binding site [chemical binding]; other site 706587005665 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 706587005666 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 706587005667 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 706587005668 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587005669 catalytic loop [active] 706587005670 iron binding site [ion binding]; other site 706587005671 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587005672 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 706587005673 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587005674 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587005675 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 706587005676 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 706587005677 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 706587005678 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 706587005679 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587005680 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 706587005681 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587005682 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587005683 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 706587005684 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 706587005685 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 706587005686 DctM-like transporters; Region: DctM; pfam06808 706587005687 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 706587005688 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587005689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005690 active site 706587005691 phosphorylation site [posttranslational modification] 706587005692 intermolecular recognition site; other site 706587005693 dimerization interface [polypeptide binding]; other site 706587005694 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 706587005695 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970 706587005696 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 706587005697 putative active site [active] 706587005698 putative metal binding site [ion binding]; other site 706587005699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587005700 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587005701 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 706587005702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587005703 Walker A/P-loop; other site 706587005704 ATP binding site [chemical binding]; other site 706587005705 Q-loop/lid; other site 706587005706 ABC transporter signature motif; other site 706587005707 Walker B; other site 706587005708 D-loop; other site 706587005709 H-loop/switch region; other site 706587005710 TOBE domain; Region: TOBE; cl01440 706587005711 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 706587005712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587005713 dimer interface [polypeptide binding]; other site 706587005714 conserved gate region; other site 706587005715 putative PBP binding loops; other site 706587005716 ABC-ATPase subunit interface; other site 706587005717 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 706587005718 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 706587005719 Predicted transcriptional regulators [Transcription]; Region: COG1695 706587005720 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 706587005721 Domain of unknown function (DUF364); Region: DUF364; pfam04016 706587005722 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 706587005723 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 706587005724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587005725 dimer interface [polypeptide binding]; other site 706587005726 conserved gate region; other site 706587005727 putative PBP binding loops; other site 706587005728 ABC-ATPase subunit interface; other site 706587005729 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 706587005730 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 706587005731 Walker A/P-loop; other site 706587005732 ATP binding site [chemical binding]; other site 706587005733 Q-loop/lid; other site 706587005734 ABC transporter signature motif; other site 706587005735 Walker B; other site 706587005736 D-loop; other site 706587005737 H-loop/switch region; other site 706587005738 Response regulator receiver domain; Region: Response_reg; pfam00072 706587005739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005740 active site 706587005741 phosphorylation site [posttranslational modification] 706587005742 intermolecular recognition site; other site 706587005743 dimerization interface [polypeptide binding]; other site 706587005744 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 706587005745 PhoU domain; Region: PhoU; pfam01895 706587005746 PhoU domain; Region: PhoU; pfam01895 706587005747 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587005748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005749 active site 706587005750 phosphorylation site [posttranslational modification] 706587005751 intermolecular recognition site; other site 706587005752 dimerization interface [polypeptide binding]; other site 706587005753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587005754 Walker A motif; other site 706587005755 ATP binding site [chemical binding]; other site 706587005756 Walker B motif; other site 706587005757 arginine finger; other site 706587005758 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 706587005759 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 706587005760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587005761 dimerization interface [polypeptide binding]; other site 706587005762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587005763 dimer interface [polypeptide binding]; other site 706587005764 phosphorylation site [posttranslational modification] 706587005765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587005766 ATP binding site [chemical binding]; other site 706587005767 Mg2+ binding site [ion binding]; other site 706587005768 G-X-G motif; other site 706587005769 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 706587005770 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 706587005771 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 706587005772 Soluble P-type ATPase [General function prediction only]; Region: COG4087 706587005773 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 706587005774 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 706587005775 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 706587005776 Ligand Binding Site [chemical binding]; other site 706587005777 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 706587005778 active site 706587005779 phosphorylation site [posttranslational modification] 706587005780 HPP family; Region: HPP; pfam04982 706587005781 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 706587005782 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 706587005783 active site 706587005784 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 706587005785 catalytic tetrad [active] 706587005786 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 706587005787 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706587005788 dimerization interface [polypeptide binding]; other site 706587005789 putative DNA binding site [nucleotide binding]; other site 706587005790 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 706587005791 Bax inhibitor 1 like; Region: BaxI_1; cl17691 706587005792 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 706587005793 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005794 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587005795 putative active site [active] 706587005796 heme pocket [chemical binding]; other site 706587005797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587005798 dimer interface [polypeptide binding]; other site 706587005799 phosphorylation site [posttranslational modification] 706587005800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587005801 ATP binding site [chemical binding]; other site 706587005802 Mg2+ binding site [ion binding]; other site 706587005803 G-X-G motif; other site 706587005804 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 706587005805 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587005806 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587005807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587005808 binding surface 706587005809 TPR motif; other site 706587005810 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587005811 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587005812 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 706587005813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587005814 Walker A/P-loop; other site 706587005815 ATP binding site [chemical binding]; other site 706587005816 Q-loop/lid; other site 706587005817 ABC transporter signature motif; other site 706587005818 Walker B; other site 706587005819 D-loop; other site 706587005820 H-loop/switch region; other site 706587005821 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 706587005822 ABC-2 type transporter; Region: ABC2_membrane; cl17235 706587005823 amino acid transporter; Region: 2A0306; TIGR00909 706587005824 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 706587005825 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 706587005826 L-aspartate oxidase; Provisional; Region: PRK06175 706587005827 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 706587005828 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 706587005829 Iron-sulfur protein interface; other site 706587005830 proximal heme binding site [chemical binding]; other site 706587005831 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 706587005832 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587005833 catalytic loop [active] 706587005834 iron binding site [ion binding]; other site 706587005835 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 706587005836 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 706587005837 iron-sulfur cluster [ion binding]; other site 706587005838 [2Fe-2S] cluster binding site [ion binding]; other site 706587005839 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 706587005840 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 706587005841 heme bL binding site [chemical binding]; other site 706587005842 interchain domain interface [polypeptide binding]; other site 706587005843 intrachain domain interface; other site 706587005844 heme bH binding site [chemical binding]; other site 706587005845 Qo binding site; other site 706587005846 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 706587005847 intrachain domain interface; other site 706587005848 Qo binding site; other site 706587005849 Cytochrome c; Region: Cytochrom_C; pfam00034 706587005850 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 706587005851 Fumarase C-terminus; Region: Fumerase_C; cl00795 706587005852 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 706587005853 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 706587005854 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 706587005855 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 706587005856 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 706587005857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587005858 Walker A motif; other site 706587005859 ATP binding site [chemical binding]; other site 706587005860 Walker B motif; other site 706587005861 arginine finger; other site 706587005862 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 706587005863 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 706587005864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587005865 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706587005866 putative substrate translocation pore; other site 706587005867 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587005868 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587005869 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587005870 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587005871 Ankyrin repeat; Region: Ank; pfam00023 706587005872 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587005873 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587005874 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587005875 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587005876 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 706587005877 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 706587005878 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 706587005879 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 706587005880 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 706587005881 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706587005882 AlkA N-terminal domain; Region: AlkA_N; pfam06029 706587005883 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 706587005884 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 706587005885 minor groove reading motif; other site 706587005886 helix-hairpin-helix signature motif; other site 706587005887 substrate binding pocket [chemical binding]; other site 706587005888 active site 706587005889 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 706587005890 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 706587005891 DNA binding site [nucleotide binding] 706587005892 active site 706587005893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005894 active site 706587005895 phosphorylation site [posttranslational modification] 706587005896 intermolecular recognition site; other site 706587005897 dimerization interface [polypeptide binding]; other site 706587005898 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005899 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587005900 putative active site [active] 706587005901 heme pocket [chemical binding]; other site 706587005902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005903 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587005904 putative active site [active] 706587005905 heme pocket [chemical binding]; other site 706587005906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005907 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587005908 putative active site [active] 706587005909 heme pocket [chemical binding]; other site 706587005910 PAS fold; Region: PAS_4; pfam08448 706587005911 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587005912 putative active site [active] 706587005913 heme pocket [chemical binding]; other site 706587005914 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587005915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587005916 Walker A motif; other site 706587005917 ATP binding site [chemical binding]; other site 706587005918 Walker B motif; other site 706587005919 arginine finger; other site 706587005920 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 706587005921 Response regulator receiver domain; Region: Response_reg; pfam00072 706587005922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587005923 active site 706587005924 phosphorylation site [posttranslational modification] 706587005925 intermolecular recognition site; other site 706587005926 dimerization interface [polypeptide binding]; other site 706587005927 Cache domain; Region: Cache_1; pfam02743 706587005928 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587005929 dimerization interface [polypeptide binding]; other site 706587005930 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706587005931 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 706587005932 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587005933 dimer interface [polypeptide binding]; other site 706587005934 phosphorylation site [posttranslational modification] 706587005935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587005936 ATP binding site [chemical binding]; other site 706587005937 Mg2+ binding site [ion binding]; other site 706587005938 G-X-G motif; other site 706587005939 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587005940 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587005941 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 706587005942 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587005943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587005944 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 706587005945 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 706587005946 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 706587005947 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 706587005948 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587005949 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587005950 Cysteine-rich domain; Region: CCG; pfam02754 706587005951 Cysteine-rich domain; Region: CCG; pfam02754 706587005952 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 706587005953 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 706587005954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587005955 4Fe-4S binding domain; Region: Fer4_6; pfam12837 706587005956 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587005957 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 706587005958 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706587005959 putative DNA binding site [nucleotide binding]; other site 706587005960 putative Zn2+ binding site [ion binding]; other site 706587005961 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 706587005962 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 706587005963 putative dimer interface [polypeptide binding]; other site 706587005964 [2Fe-2S] cluster binding site [ion binding]; other site 706587005965 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 706587005966 dimer interface [polypeptide binding]; other site 706587005967 [2Fe-2S] cluster binding site [ion binding]; other site 706587005968 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 706587005969 SLBB domain; Region: SLBB; pfam10531 706587005970 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 706587005971 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 706587005972 4Fe-4S binding domain; Region: Fer4; pfam00037 706587005973 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587005974 catalytic loop [active] 706587005975 iron binding site [ion binding]; other site 706587005976 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587005977 Tic20-like protein; Region: Tic20; pfam09685 706587005978 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 706587005979 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 706587005980 UbiA prenyltransferase family; Region: UbiA; pfam01040 706587005981 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 706587005982 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 706587005983 Subunit I/III interface [polypeptide binding]; other site 706587005984 Subunit III/IV interface [polypeptide binding]; other site 706587005985 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 706587005986 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 706587005987 D-pathway; other site 706587005988 Putative ubiquinol binding site [chemical binding]; other site 706587005989 Low-spin heme (heme b) binding site [chemical binding]; other site 706587005990 Putative water exit pathway; other site 706587005991 Binuclear center (heme o3/CuB) [ion binding]; other site 706587005992 K-pathway; other site 706587005993 Putative proton exit pathway; other site 706587005994 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 706587005995 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 706587005996 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 706587005997 manganese transport protein MntH; Reviewed; Region: PRK00701 706587005998 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 706587005999 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706587006000 Ligand Binding Site [chemical binding]; other site 706587006001 Short C-terminal domain; Region: SHOCT; pfam09851 706587006002 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 706587006003 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 706587006004 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 706587006005 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 706587006006 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 706587006007 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 706587006008 Soluble P-type ATPase [General function prediction only]; Region: COG4087 706587006009 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 706587006010 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 706587006011 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 706587006012 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 706587006013 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 706587006014 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 706587006015 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 706587006016 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 706587006017 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 706587006018 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 706587006019 protein binding site [polypeptide binding]; other site 706587006020 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 706587006021 protein binding site [polypeptide binding]; other site 706587006022 hypothetical protein; Provisional; Region: PRK09947 706587006023 putative oxidoreductase; Provisional; Region: PRK09849 706587006024 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 706587006025 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 706587006026 hypothetical protein; Provisional; Region: PRK09898 706587006027 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 706587006028 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006029 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006030 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006031 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006032 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006033 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006034 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006035 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006036 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 706587006037 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006038 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006039 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006040 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006041 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006042 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006043 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006044 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006045 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006046 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006047 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006048 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006049 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006050 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006051 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006052 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006053 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006054 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006055 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006056 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006057 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006058 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006059 VCBS repeat; Region: VCBS_repeat; TIGR01965 706587006060 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 706587006061 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 706587006062 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 706587006063 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 706587006064 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 706587006065 FMN binding site [chemical binding]; other site 706587006066 active site 706587006067 substrate binding site [chemical binding]; other site 706587006068 catalytic residue [active] 706587006069 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 706587006070 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 706587006071 putative dimer interface [polypeptide binding]; other site 706587006072 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 706587006073 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706587006074 ligand binding site [chemical binding]; other site 706587006075 flexible hinge region; other site 706587006076 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706587006077 Ligand Binding Site [chemical binding]; other site 706587006078 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 706587006079 PAS domain S-box; Region: sensory_box; TIGR00229 706587006080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006081 putative active site [active] 706587006082 heme pocket [chemical binding]; other site 706587006083 PAS domain; Region: PAS_8; pfam13188 706587006084 PAS fold; Region: PAS_4; pfam08448 706587006085 PAS fold; Region: PAS_4; pfam08448 706587006086 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006087 putative active site [active] 706587006088 heme pocket [chemical binding]; other site 706587006089 histidine kinase; Provisional; Region: PRK13557 706587006090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006091 putative active site [active] 706587006092 heme pocket [chemical binding]; other site 706587006093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587006094 dimer interface [polypeptide binding]; other site 706587006095 phosphorylation site [posttranslational modification] 706587006096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587006097 ATP binding site [chemical binding]; other site 706587006098 Mg2+ binding site [ion binding]; other site 706587006099 G-X-G motif; other site 706587006100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587006101 active site 706587006102 phosphorylation site [posttranslational modification] 706587006103 intermolecular recognition site; other site 706587006104 dimerization interface [polypeptide binding]; other site 706587006105 PAS domain S-box; Region: sensory_box; TIGR00229 706587006106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006107 putative active site [active] 706587006108 heme pocket [chemical binding]; other site 706587006109 PAS domain S-box; Region: sensory_box; TIGR00229 706587006110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006111 putative active site [active] 706587006112 heme pocket [chemical binding]; other site 706587006113 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587006114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006115 putative active site [active] 706587006116 heme pocket [chemical binding]; other site 706587006117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587006118 dimer interface [polypeptide binding]; other site 706587006119 phosphorylation site [posttranslational modification] 706587006120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587006121 ATP binding site [chemical binding]; other site 706587006122 Mg2+ binding site [ion binding]; other site 706587006123 G-X-G motif; other site 706587006124 Response regulator receiver domain; Region: Response_reg; pfam00072 706587006125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587006126 active site 706587006127 phosphorylation site [posttranslational modification] 706587006128 intermolecular recognition site; other site 706587006129 dimerization interface [polypeptide binding]; other site 706587006130 Response regulator receiver domain; Region: Response_reg; pfam00072 706587006131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587006132 active site 706587006133 phosphorylation site [posttranslational modification] 706587006134 intermolecular recognition site; other site 706587006135 dimerization interface [polypeptide binding]; other site 706587006136 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 706587006137 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587006138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587006139 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587006140 FOG: CBS domain [General function prediction only]; Region: COG0517 706587006141 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 706587006142 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 706587006143 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706587006144 Ligand Binding Site [chemical binding]; other site 706587006145 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 706587006146 Active_site [active] 706587006147 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 706587006148 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 706587006149 Uncharacterized conserved protein [Function unknown]; Region: COG2006 706587006150 4Fe-4S binding domain; Region: Fer4_6; pfam12837 706587006151 xanthine permease; Region: pbuX; TIGR03173 706587006152 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 706587006153 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706587006154 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 706587006155 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 706587006156 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 706587006157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006158 PAS domain; Region: PAS_9; pfam13426 706587006159 putative active site [active] 706587006160 heme pocket [chemical binding]; other site 706587006161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587006162 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 706587006163 Walker A motif; other site 706587006164 ATP binding site [chemical binding]; other site 706587006165 Walker B motif; other site 706587006166 arginine finger; other site 706587006167 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587006168 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 706587006169 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 706587006170 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 706587006171 Walker A motif; other site 706587006172 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 706587006173 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 706587006174 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 706587006175 active site 706587006176 trimerization site [polypeptide binding]; other site 706587006177 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 706587006178 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587006179 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587006180 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587006181 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 706587006182 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 706587006183 P loop nucleotide binding; other site 706587006184 switch II; other site 706587006185 Domain of unknown function DUF59; Region: DUF59; pfam01883 706587006186 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 706587006187 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 706587006188 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 706587006189 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 706587006190 trimerization site [polypeptide binding]; other site 706587006191 active site 706587006192 Uncharacterized conserved protein [Function unknown]; Region: COG2014 706587006193 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 706587006194 Domain of unknown function (DUF364); Region: DUF364; pfam04016 706587006195 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 706587006196 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 706587006197 homodimer interaction site [polypeptide binding]; other site 706587006198 cofactor binding site; other site 706587006199 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 706587006200 DctM-like transporters; Region: DctM; pfam06808 706587006201 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 706587006202 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 706587006203 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 706587006204 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 706587006205 catalytic residues [active] 706587006206 PemK-like protein; Region: PemK; pfam02452 706587006207 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 706587006208 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 706587006209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587006210 binding surface 706587006211 TPR motif; other site 706587006212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587006213 binding surface 706587006214 TPR motif; other site 706587006215 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587006216 binding surface 706587006217 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587006218 TPR motif; other site 706587006219 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 706587006220 dimer interface [polypeptide binding]; other site 706587006221 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706587006222 Ligand Binding Site [chemical binding]; other site 706587006223 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587006224 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587006225 Walker A/P-loop; other site 706587006226 ATP binding site [chemical binding]; other site 706587006227 Q-loop/lid; other site 706587006228 ABC transporter signature motif; other site 706587006229 Walker B; other site 706587006230 D-loop; other site 706587006231 H-loop/switch region; other site 706587006232 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587006233 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587006234 Walker A/P-loop; other site 706587006235 ATP binding site [chemical binding]; other site 706587006236 Q-loop/lid; other site 706587006237 ABC transporter signature motif; other site 706587006238 Walker B; other site 706587006239 D-loop; other site 706587006240 H-loop/switch region; other site 706587006241 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587006242 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587006243 TM-ABC transporter signature motif; other site 706587006244 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587006245 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587006246 TM-ABC transporter signature motif; other site 706587006247 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587006248 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587006249 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 706587006250 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 706587006251 NADP binding site [chemical binding]; other site 706587006252 homodimer interface [polypeptide binding]; other site 706587006253 active site 706587006254 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 706587006255 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 706587006256 putative active site [active] 706587006257 metal binding site [ion binding]; metal-binding site 706587006258 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587006259 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587006260 Walker A/P-loop; other site 706587006261 ATP binding site [chemical binding]; other site 706587006262 Q-loop/lid; other site 706587006263 ABC transporter signature motif; other site 706587006264 Walker B; other site 706587006265 D-loop; other site 706587006266 H-loop/switch region; other site 706587006267 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587006268 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587006269 Walker A/P-loop; other site 706587006270 ATP binding site [chemical binding]; other site 706587006271 Q-loop/lid; other site 706587006272 ABC transporter signature motif; other site 706587006273 Walker B; other site 706587006274 D-loop; other site 706587006275 H-loop/switch region; other site 706587006276 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587006277 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587006278 TM-ABC transporter signature motif; other site 706587006279 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587006280 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587006281 TM-ABC transporter signature motif; other site 706587006282 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587006283 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 706587006284 putative ligand binding site [chemical binding]; other site 706587006285 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 706587006286 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 706587006287 acyl-activating enzyme (AAE) consensus motif; other site 706587006288 putative AMP binding site [chemical binding]; other site 706587006289 putative active site [active] 706587006290 putative CoA binding site [chemical binding]; other site 706587006291 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 706587006292 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587006293 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 706587006294 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 706587006295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587006296 non-specific DNA binding site [nucleotide binding]; other site 706587006297 salt bridge; other site 706587006298 sequence-specific DNA binding site [nucleotide binding]; other site 706587006299 Cupin domain; Region: Cupin_2; pfam07883 706587006300 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 706587006301 Coenzyme A transferase; Region: CoA_trans; cl17247 706587006302 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 706587006303 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587006304 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587006305 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587006306 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587006307 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 706587006308 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587006309 catalytic loop [active] 706587006310 iron binding site [ion binding]; other site 706587006311 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587006312 Putative addiction module component; Region: Unstab_antitox; pfam09720 706587006313 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 706587006314 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587006315 sequence-specific DNA binding site [nucleotide binding]; other site 706587006316 salt bridge; other site 706587006317 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 706587006318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587006319 S-adenosylmethionine binding site [chemical binding]; other site 706587006320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006321 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587006322 putative active site [active] 706587006323 heme pocket [chemical binding]; other site 706587006324 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006325 putative active site [active] 706587006326 heme pocket [chemical binding]; other site 706587006327 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587006328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587006329 Walker A motif; other site 706587006330 ATP binding site [chemical binding]; other site 706587006331 Walker B motif; other site 706587006332 arginine finger; other site 706587006333 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 706587006334 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 706587006335 CheB methylesterase; Region: CheB_methylest; pfam01339 706587006336 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 706587006337 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 706587006338 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 706587006339 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 706587006340 Protein of unknown function (DUF904); Region: DUF904; pfam06005 706587006341 PAS domain; Region: PAS_10; pfam13596 706587006342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006343 PAS domain; Region: PAS_9; pfam13426 706587006344 putative active site [active] 706587006345 heme pocket [chemical binding]; other site 706587006346 Low affinity iron permease; Region: Iron_permease; pfam04120 706587006347 oxidoreductase; Validated; Region: PRK05717 706587006348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706587006349 NAD(P) binding site [chemical binding]; other site 706587006350 active site 706587006351 Response regulator receiver domain; Region: Response_reg; pfam00072 706587006352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587006353 active site 706587006354 phosphorylation site [posttranslational modification] 706587006355 intermolecular recognition site; other site 706587006356 dimerization interface [polypeptide binding]; other site 706587006357 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 706587006358 Beta-lactamase; Region: Beta-lactamase; pfam00144 706587006359 Transmembrane secretion effector; Region: MFS_3; pfam05977 706587006360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587006361 putative substrate translocation pore; other site 706587006362 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706587006363 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 706587006364 substrate binding pocket [chemical binding]; other site 706587006365 membrane-bound complex binding site; other site 706587006366 hinge residues; other site 706587006367 PAS domain S-box; Region: sensory_box; TIGR00229 706587006368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006369 putative active site [active] 706587006370 heme pocket [chemical binding]; other site 706587006371 PAS domain S-box; Region: sensory_box; TIGR00229 706587006372 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006373 putative active site [active] 706587006374 heme pocket [chemical binding]; other site 706587006375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587006376 dimer interface [polypeptide binding]; other site 706587006377 phosphorylation site [posttranslational modification] 706587006378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587006379 ATP binding site [chemical binding]; other site 706587006380 Mg2+ binding site [ion binding]; other site 706587006381 G-X-G motif; other site 706587006382 Response regulator receiver domain; Region: Response_reg; pfam00072 706587006383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587006384 active site 706587006385 phosphorylation site [posttranslational modification] 706587006386 intermolecular recognition site; other site 706587006387 dimerization interface [polypeptide binding]; other site 706587006388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587006389 Rubrerythrin [Energy production and conversion]; Region: COG1592 706587006390 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 706587006391 binuclear metal center [ion binding]; other site 706587006392 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 706587006393 iron binding site [ion binding]; other site 706587006394 methylamine methyltransferase corrinoid protein reductive activase; Region: Rama_corrin_act; TIGR04270 706587006395 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 706587006396 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 706587006397 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 706587006398 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 706587006399 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 706587006400 Methanol-cobalamin methyltransferase B subunit; Region: MtaB; pfam12176 706587006401 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 706587006402 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 706587006403 B12 binding site [chemical binding]; other site 706587006404 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 706587006405 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 706587006406 Putative Fe-S cluster; Region: FeS; cl17515 706587006407 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 706587006408 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587006409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587006410 active site 706587006411 phosphorylation site [posttranslational modification] 706587006412 intermolecular recognition site; other site 706587006413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587006414 Walker A motif; other site 706587006415 ATP binding site [chemical binding]; other site 706587006416 Walker B motif; other site 706587006417 arginine finger; other site 706587006418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587006419 dimer interface [polypeptide binding]; other site 706587006420 phosphorylation site [posttranslational modification] 706587006421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587006422 ATP binding site [chemical binding]; other site 706587006423 Mg2+ binding site [ion binding]; other site 706587006424 G-X-G motif; other site 706587006425 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 706587006426 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 706587006427 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 706587006428 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 706587006429 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 706587006430 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 706587006431 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 706587006432 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 706587006433 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 706587006434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006435 putative active site [active] 706587006436 heme pocket [chemical binding]; other site 706587006437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006438 putative active site [active] 706587006439 heme pocket [chemical binding]; other site 706587006440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587006441 Walker A motif; other site 706587006442 ATP binding site [chemical binding]; other site 706587006443 Walker B motif; other site 706587006444 arginine finger; other site 706587006445 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587006446 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 706587006447 Uncharacterized conserved protein [Function unknown]; Region: COG2128 706587006448 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 706587006449 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 706587006450 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587006451 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 706587006452 active site 706587006453 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 706587006454 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587006455 acyl-activating enzyme (AAE) consensus motif; other site 706587006456 AMP binding site [chemical binding]; other site 706587006457 active site 706587006458 CoA binding site [chemical binding]; other site 706587006459 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587006460 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587006461 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 706587006462 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 706587006463 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 706587006464 PAS domain; Region: PAS_9; pfam13426 706587006465 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587006466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587006467 ATP binding site [chemical binding]; other site 706587006468 Mg2+ binding site [ion binding]; other site 706587006469 G-X-G motif; other site 706587006470 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587006471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587006472 active site 706587006473 phosphorylation site [posttranslational modification] 706587006474 intermolecular recognition site; other site 706587006475 dimerization interface [polypeptide binding]; other site 706587006476 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 706587006477 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587006478 active site 706587006479 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 706587006480 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587006481 non-specific DNA binding site [nucleotide binding]; other site 706587006482 salt bridge; other site 706587006483 sequence-specific DNA binding site [nucleotide binding]; other site 706587006484 Cupin domain; Region: Cupin_2; pfam07883 706587006485 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587006486 Cysteine-rich domain; Region: CCG; pfam02754 706587006487 Cysteine-rich domain; Region: CCG; pfam02754 706587006488 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 706587006489 Ligand binding site [chemical binding]; other site 706587006490 Electron transfer flavoprotein domain; Region: ETF; pfam01012 706587006491 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 706587006492 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 706587006493 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 706587006494 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587006495 dimerization interface [polypeptide binding]; other site 706587006496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006497 PAS domain; Region: PAS_9; pfam13426 706587006498 putative active site [active] 706587006499 heme pocket [chemical binding]; other site 706587006500 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587006501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587006502 dimer interface [polypeptide binding]; other site 706587006503 phosphorylation site [posttranslational modification] 706587006504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587006505 ATP binding site [chemical binding]; other site 706587006506 Mg2+ binding site [ion binding]; other site 706587006507 G-X-G motif; other site 706587006508 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 706587006509 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 706587006510 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706587006511 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 706587006512 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587006513 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 706587006514 active site 706587006515 Int/Topo IB signature motif; other site 706587006516 catalytic residues [active] 706587006517 DNA binding site [nucleotide binding] 706587006518 TOBE domain; Region: TOBE; cl01440 706587006519 TOBE domain; Region: TOBE; cl01440 706587006520 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706587006521 Ligand Binding Site [chemical binding]; other site 706587006522 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 706587006523 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706587006524 dimerization interface [polypeptide binding]; other site 706587006525 putative DNA binding site [nucleotide binding]; other site 706587006526 putative Zn2+ binding site [ion binding]; other site 706587006527 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 706587006528 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 706587006529 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 706587006530 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 706587006531 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 706587006532 DsbD alpha interface [polypeptide binding]; other site 706587006533 catalytic residues [active] 706587006534 4Fe-4S binding domain; Region: Fer4_5; pfam12801 706587006535 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 706587006536 lipoyl-biotinyl attachment site [posttranslational modification]; other site 706587006537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587006538 S-adenosylmethionine binding site [chemical binding]; other site 706587006539 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 706587006540 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 706587006541 Predicted membrane protein [Function unknown]; Region: COG3462 706587006542 Short C-terminal domain; Region: SHOCT; pfam09851 706587006543 TPR repeat; Region: TPR_11; pfam13414 706587006544 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587006545 binding surface 706587006546 TPR motif; other site 706587006547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587006548 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587006549 TPR motif; other site 706587006550 binding surface 706587006551 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 706587006552 DinB superfamily; Region: DinB_2; pfam12867 706587006553 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 706587006554 EamA-like transporter family; Region: EamA; pfam00892 706587006555 EamA-like transporter family; Region: EamA; pfam00892 706587006556 benzoate transport; Region: 2A0115; TIGR00895 706587006557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587006558 putative substrate translocation pore; other site 706587006559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587006560 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 706587006561 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 706587006562 substrate binding pocket [chemical binding]; other site 706587006563 dimer interface [polypeptide binding]; other site 706587006564 inhibitor binding site; inhibition site 706587006565 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 706587006566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006567 putative active site [active] 706587006568 heme pocket [chemical binding]; other site 706587006569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006570 putative active site [active] 706587006571 heme pocket [chemical binding]; other site 706587006572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587006573 Walker A motif; other site 706587006574 ATP binding site [chemical binding]; other site 706587006575 Walker B motif; other site 706587006576 arginine finger; other site 706587006577 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 706587006578 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 706587006579 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 706587006580 B12 binding site [chemical binding]; other site 706587006581 cobalt ligand [ion binding]; other site 706587006582 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 706587006583 benzoate transport; Region: 2A0115; TIGR00895 706587006584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587006585 putative substrate translocation pore; other site 706587006586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587006587 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 706587006588 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 706587006589 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 706587006590 metal ion-dependent adhesion site (MIDAS); other site 706587006591 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 706587006592 active site 706587006593 substrate binding site [chemical binding]; other site 706587006594 ATP binding site [chemical binding]; other site 706587006595 Protein phosphatase 2C; Region: PP2C_2; pfam13672 706587006596 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 706587006597 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 706587006598 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 706587006599 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 706587006600 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 706587006601 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 706587006602 putative active site [active] 706587006603 catalytic residue [active] 706587006604 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 706587006605 active site 706587006606 dimer interface [polypeptide binding]; other site 706587006607 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 706587006608 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 706587006609 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 706587006610 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 706587006611 TPP-binding site [chemical binding]; other site 706587006612 dimer interface [polypeptide binding]; other site 706587006613 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 706587006614 PYR/PP interface [polypeptide binding]; other site 706587006615 dimer interface [polypeptide binding]; other site 706587006616 TPP binding site [chemical binding]; other site 706587006617 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706587006618 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 706587006619 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587006620 Tho complex subunit 7; Region: THOC7; pfam05615 706587006621 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587006622 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 706587006623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587006624 putative substrate translocation pore; other site 706587006625 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587006626 Catalytic beta propeller domain of bacteriophage endosialidase; Region: End_beta_propel; cl12167 706587006627 Vanadium-binding protein 2; Region: Vanabin-2; pfam11437 706587006628 succinic semialdehyde dehydrogenase; Region: PLN02278 706587006629 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 706587006630 tetramerization interface [polypeptide binding]; other site 706587006631 NAD(P) binding site [chemical binding]; other site 706587006632 catalytic residues [active] 706587006633 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 706587006634 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 706587006635 ATP-grasp domain; Region: ATP-grasp_4; cl17255 706587006636 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 706587006637 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 706587006638 carboxyltransferase (CT) interaction site; other site 706587006639 biotinylation site [posttranslational modification]; other site 706587006640 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 706587006641 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 706587006642 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 706587006643 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 706587006644 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 706587006645 inhibitor-cofactor binding pocket; inhibition site 706587006646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587006647 catalytic residue [active] 706587006648 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 706587006649 putative active site [active] 706587006650 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587006651 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706587006652 TM-ABC transporter signature motif; other site 706587006653 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 706587006654 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706587006655 Walker A/P-loop; other site 706587006656 ATP binding site [chemical binding]; other site 706587006657 Q-loop/lid; other site 706587006658 ABC transporter signature motif; other site 706587006659 Walker B; other site 706587006660 D-loop; other site 706587006661 H-loop/switch region; other site 706587006662 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 706587006663 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 706587006664 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587006665 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 706587006666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006667 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006668 putative active site [active] 706587006669 heme pocket [chemical binding]; other site 706587006670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587006671 Walker A motif; other site 706587006672 ATP binding site [chemical binding]; other site 706587006673 Walker B motif; other site 706587006674 arginine finger; other site 706587006675 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587006676 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 706587006677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587006678 active site 706587006679 phosphorylation site [posttranslational modification] 706587006680 intermolecular recognition site; other site 706587006681 dimerization interface [polypeptide binding]; other site 706587006682 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706587006683 DNA binding residues [nucleotide binding] 706587006684 dimerization interface [polypeptide binding]; other site 706587006685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587006686 putative substrate translocation pore; other site 706587006687 benzoate transport; Region: 2A0115; TIGR00895 706587006688 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 706587006689 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706587006690 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587006691 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 706587006692 catalytic residues [active] 706587006693 Sulfatase; Region: Sulfatase; pfam00884 706587006694 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 706587006695 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587006696 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 706587006697 substrate binding site [chemical binding]; other site 706587006698 oxyanion hole (OAH) forming residues; other site 706587006699 trimer interface [polypeptide binding]; other site 706587006700 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 706587006701 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 706587006702 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 706587006703 acetyl-CoA acetyltransferase; Provisional; Region: PRK06445 706587006704 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 706587006705 dimer interface [polypeptide binding]; other site 706587006706 active site 706587006707 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 706587006708 4Fe-4S binding domain; Region: Fer4; cl02805 706587006709 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 706587006710 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 706587006711 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 706587006712 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587006713 active site 706587006714 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 706587006715 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 706587006716 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587006717 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587006718 acyl-activating enzyme (AAE) consensus motif; other site 706587006719 acyl-activating enzyme (AAE) consensus motif; other site 706587006720 active site 706587006721 AMP binding site [chemical binding]; other site 706587006722 CoA binding site [chemical binding]; other site 706587006723 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 706587006724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006725 putative active site [active] 706587006726 heme pocket [chemical binding]; other site 706587006727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587006728 Walker A motif; other site 706587006729 ATP binding site [chemical binding]; other site 706587006730 Walker B motif; other site 706587006731 arginine finger; other site 706587006732 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 706587006733 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14535 706587006734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587006735 AAA domain; Region: AAA_21; pfam13304 706587006736 Walker A/P-loop; other site 706587006737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 706587006738 ABC transporter signature motif; other site 706587006739 Walker B; other site 706587006740 D-loop; other site 706587006741 H-loop/switch region; other site 706587006742 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 706587006743 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 706587006744 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587006745 active site 706587006746 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 706587006747 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 706587006748 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587006749 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587006750 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587006751 Walker A/P-loop; other site 706587006752 ATP binding site [chemical binding]; other site 706587006753 Q-loop/lid; other site 706587006754 ABC transporter signature motif; other site 706587006755 Walker B; other site 706587006756 D-loop; other site 706587006757 H-loop/switch region; other site 706587006758 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587006759 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587006760 Walker A/P-loop; other site 706587006761 ATP binding site [chemical binding]; other site 706587006762 Q-loop/lid; other site 706587006763 ABC transporter signature motif; other site 706587006764 Walker B; other site 706587006765 D-loop; other site 706587006766 H-loop/switch region; other site 706587006767 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587006768 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587006769 TM-ABC transporter signature motif; other site 706587006770 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587006771 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587006772 TM-ABC transporter signature motif; other site 706587006773 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 706587006774 classical (c) SDRs; Region: SDR_c; cd05233 706587006775 NAD(P) binding site [chemical binding]; other site 706587006776 active site 706587006777 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587006778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587006779 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 706587006780 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587006781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587006782 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 706587006783 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 706587006784 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 706587006785 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 706587006786 putative acyltransferase; Provisional; Region: PRK05790 706587006787 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 706587006788 dimer interface [polypeptide binding]; other site 706587006789 active site 706587006790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587006791 putative substrate translocation pore; other site 706587006792 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706587006793 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706587006794 Ligand Binding Site [chemical binding]; other site 706587006795 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 706587006796 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 706587006797 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 706587006798 Dynamin family; Region: Dynamin_N; pfam00350 706587006799 G1 box; other site 706587006800 GTP/Mg2+ binding site [chemical binding]; other site 706587006801 G2 box; other site 706587006802 Switch I region; other site 706587006803 G3 box; other site 706587006804 Switch II region; other site 706587006805 G4 box; other site 706587006806 G5 box; other site 706587006807 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 706587006808 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 706587006809 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 706587006810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587006811 non-specific DNA binding site [nucleotide binding]; other site 706587006812 salt bridge; other site 706587006813 sequence-specific DNA binding site [nucleotide binding]; other site 706587006814 Domain of unknown function (DUF955); Region: DUF955; pfam06114 706587006815 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 706587006816 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 706587006817 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 706587006818 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 706587006819 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 706587006820 DNA binding residues [nucleotide binding] 706587006821 Helix-turn-helix domain; Region: HTH_17; pfam12728 706587006822 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 706587006823 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 706587006824 active site 706587006825 catalytic residues [active] 706587006826 DNA binding site [nucleotide binding] 706587006827 Int/Topo IB signature motif; other site 706587006828 ribbon-helix-helix domain containing protein; Region: PHA00617 706587006829 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 706587006830 multiple promoter invertase; Provisional; Region: mpi; PRK13413 706587006831 catalytic residues [active] 706587006832 catalytic nucleophile [active] 706587006833 Presynaptic Site I dimer interface [polypeptide binding]; other site 706587006834 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 706587006835 Synaptic Flat tetramer interface [polypeptide binding]; other site 706587006836 Synaptic Site I dimer interface [polypeptide binding]; other site 706587006837 DNA binding site [nucleotide binding] 706587006838 Recombinase; Region: Recombinase; pfam07508 706587006839 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 706587006840 polymerase nucleotide-binding site; other site 706587006841 DNA-binding residues [nucleotide binding]; DNA binding site 706587006842 nucleotide binding site [chemical binding]; other site 706587006843 primase nucleotide-binding site [nucleotide binding]; other site 706587006844 AAA domain; Region: AAA_25; pfam13481 706587006845 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 706587006846 Walker A motif; other site 706587006847 ATP binding site [chemical binding]; other site 706587006848 Walker B motif; other site 706587006849 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 706587006850 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706587006851 putative Zn2+ binding site [ion binding]; other site 706587006852 putative DNA binding site [nucleotide binding]; other site 706587006853 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 706587006854 Helix-turn-helix domain; Region: HTH_17; pfam12728 706587006855 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 706587006856 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 706587006857 active site 706587006858 catalytic residues [active] 706587006859 DNA binding site [nucleotide binding] 706587006860 Int/Topo IB signature motif; other site 706587006861 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587006862 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587006863 Methyltransferase domain; Region: Methyltransf_31; pfam13847 706587006864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587006865 S-adenosylmethionine binding site [chemical binding]; other site 706587006866 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 706587006867 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 706587006868 metal binding site 2 [ion binding]; metal-binding site 706587006869 putative DNA binding helix; other site 706587006870 metal binding site 1 [ion binding]; metal-binding site 706587006871 dimer interface [polypeptide binding]; other site 706587006872 structural Zn2+ binding site [ion binding]; other site 706587006873 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 706587006874 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 706587006875 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 706587006876 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 706587006877 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 706587006878 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706587006879 ABC-ATPase subunit interface; other site 706587006880 dimer interface [polypeptide binding]; other site 706587006881 putative PBP binding regions; other site 706587006882 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 706587006883 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 706587006884 Walker A/P-loop; other site 706587006885 ATP binding site [chemical binding]; other site 706587006886 Q-loop/lid; other site 706587006887 ABC transporter signature motif; other site 706587006888 Walker B; other site 706587006889 D-loop; other site 706587006890 H-loop/switch region; other site 706587006891 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 706587006892 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 706587006893 putative metal binding site [ion binding]; other site 706587006894 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 706587006895 Protein of unknown function (DUF3419); Region: DUF3419; pfam11899 706587006896 Methyltransferase domain; Region: Methyltransf_23; pfam13489 706587006897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587006898 S-adenosylmethionine binding site [chemical binding]; other site 706587006899 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 706587006900 SnoaL-like domain; Region: SnoaL_3; pfam13474 706587006901 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 706587006902 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 706587006903 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706587006904 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587006905 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587006906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 706587006907 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 706587006908 BON domain; Region: BON; pfam04972 706587006909 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 706587006910 DctM-like transporters; Region: DctM; pfam06808 706587006911 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 706587006912 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 706587006913 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587006914 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587006915 Cysteine-rich domain; Region: CCG; pfam02754 706587006916 Cysteine-rich domain; Region: CCG; pfam02754 706587006917 FAD binding domain; Region: FAD_binding_4; pfam01565 706587006918 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 706587006919 Transcriptional regulators [Transcription]; Region: FadR; COG2186 706587006920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706587006921 DNA-binding site [nucleotide binding]; DNA binding site 706587006922 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 706587006923 L-lactate permease; Region: Lactate_perm; cl00701 706587006924 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 706587006925 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 706587006926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587006927 active site 706587006928 phosphorylation site [posttranslational modification] 706587006929 intermolecular recognition site; other site 706587006930 dimerization interface [polypeptide binding]; other site 706587006931 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587006932 Zn2+ binding site [ion binding]; other site 706587006933 Mg2+ binding site [ion binding]; other site 706587006934 PAS fold; Region: PAS; pfam00989 706587006935 PBP superfamily domain; Region: PBP_like_2; cl17296 706587006936 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587006937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587006938 active site 706587006939 phosphorylation site [posttranslational modification] 706587006940 intermolecular recognition site; other site 706587006941 dimerization interface [polypeptide binding]; other site 706587006942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587006943 Walker A motif; other site 706587006944 ATP binding site [chemical binding]; other site 706587006945 Walker B motif; other site 706587006946 arginine finger; other site 706587006947 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587006948 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 706587006949 active site 706587006950 oxyanion hole [active] 706587006951 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 706587006952 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 706587006953 putative trimer interface [polypeptide binding]; other site 706587006954 putative CoA binding site [chemical binding]; other site 706587006955 PAS domain; Region: PAS; smart00091 706587006956 PAS domain; Region: PAS_9; pfam13426 706587006957 PAS fold; Region: PAS_4; pfam08448 706587006958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587006959 putative active site [active] 706587006960 heme pocket [chemical binding]; other site 706587006961 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587006962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587006963 Walker A motif; other site 706587006964 ATP binding site [chemical binding]; other site 706587006965 Walker B motif; other site 706587006966 arginine finger; other site 706587006967 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587006968 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 706587006969 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 706587006970 active site 706587006971 FMN binding site [chemical binding]; other site 706587006972 substrate binding site [chemical binding]; other site 706587006973 putative catalytic residue [active] 706587006974 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 706587006975 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587006976 acyl-activating enzyme (AAE) consensus motif; other site 706587006977 AMP binding site [chemical binding]; other site 706587006978 active site 706587006979 CoA binding site [chemical binding]; other site 706587006980 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 706587006981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706587006982 NAD(P) binding site [chemical binding]; other site 706587006983 active site 706587006984 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 706587006985 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587006986 active site 706587006987 benzoate transport; Region: 2A0115; TIGR00895 706587006988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587006989 putative substrate translocation pore; other site 706587006990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587006991 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase; Region: dearomat_oah; TIGR03200 706587006992 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587006993 substrate binding site [chemical binding]; other site 706587006994 oxyanion hole (OAH) forming residues; other site 706587006995 trimer interface [polypeptide binding]; other site 706587006996 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 706587006997 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 706587006998 active site 706587006999 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 706587007000 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 706587007001 DUF35 OB-fold domain; Region: DUF35; pfam01796 706587007002 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 706587007003 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587007004 active site 706587007005 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 706587007006 carboxyltransferase (CT) interaction site; other site 706587007007 biotinylation site [posttranslational modification]; other site 706587007008 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 706587007009 Hemerythrin-like domain; Region: Hr-like; cd12108 706587007010 Fe binding site [ion binding]; other site 706587007011 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 706587007012 active site 706587007013 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 706587007014 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587007015 FeS/SAM binding site; other site 706587007016 Predicted transcriptional regulators [Transcription]; Region: COG1695 706587007017 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 706587007018 NosL; Region: NosL; cl01769 706587007019 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 706587007020 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 706587007021 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 706587007022 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587007023 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 706587007024 Protein phosphatase 2C; Region: PP2C; pfam00481 706587007025 active site 706587007026 Catalytic domain of Protein Kinases; Region: PKc; cd00180 706587007027 active site 706587007028 ATP binding site [chemical binding]; other site 706587007029 substrate binding site [chemical binding]; other site 706587007030 Phosphotransferase enzyme family; Region: APH; pfam01636 706587007031 activation loop (A-loop); other site 706587007032 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 706587007033 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 706587007034 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587007035 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587007036 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587007037 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587007038 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587007039 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 706587007040 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 706587007041 Walker A motif; other site 706587007042 homodimer interface [polypeptide binding]; other site 706587007043 ATP binding site [chemical binding]; other site 706587007044 hydroxycobalamin binding site [chemical binding]; other site 706587007045 Walker B motif; other site 706587007046 Predicted transcriptional regulators [Transcription]; Region: COG1725 706587007047 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706587007048 DNA-binding site [nucleotide binding]; DNA binding site 706587007049 Ferredoxin [Energy production and conversion]; Region: COG1146 706587007050 4Fe-4S binding domain; Region: Fer4; pfam00037 706587007051 Cupin domain; Region: Cupin_2; pfam07883 706587007052 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 706587007053 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 706587007054 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 706587007055 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 706587007056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587007057 non-specific DNA binding site [nucleotide binding]; other site 706587007058 salt bridge; other site 706587007059 sequence-specific DNA binding site [nucleotide binding]; other site 706587007060 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 706587007061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587007062 Helix-turn-helix; Region: HTH_3; pfam01381 706587007063 sequence-specific DNA binding site [nucleotide binding]; other site 706587007064 salt bridge; other site 706587007065 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 706587007066 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 706587007067 catalytic residues [active] 706587007068 catalytic nucleophile [active] 706587007069 Recombinase; Region: Recombinase; pfam07508 706587007070 D5 N terminal like; Region: D5_N; smart00885 706587007071 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 706587007072 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 706587007073 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 706587007074 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 706587007075 active site 706587007076 metal binding site [ion binding]; metal-binding site 706587007077 interdomain interaction site; other site 706587007078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587007079 non-specific DNA binding site [nucleotide binding]; other site 706587007080 salt bridge; other site 706587007081 sequence-specific DNA binding site [nucleotide binding]; other site 706587007082 Helix-turn-helix domain; Region: HTH_17; pfam12728 706587007083 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 706587007084 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 706587007085 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cd00397 706587007086 active site 706587007087 Int/Topo IB signature motif; other site 706587007088 DNA binding site [nucleotide binding] 706587007089 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 706587007090 active site 706587007091 phosphodiesterase YaeI; Provisional; Region: PRK11340 706587007092 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 706587007093 putative active site [active] 706587007094 putative metal binding site [ion binding]; other site 706587007095 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 706587007096 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 706587007097 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 706587007098 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 706587007099 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 706587007100 [4Fe-4S] binding site [ion binding]; other site 706587007101 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 706587007102 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 706587007103 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 706587007104 molybdopterin cofactor binding site; other site 706587007105 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 706587007106 dimer interface [polypeptide binding]; other site 706587007107 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 706587007108 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706587007109 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706587007110 DNA binding residues [nucleotide binding] 706587007111 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 706587007112 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 706587007113 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 706587007114 Probable Catalytic site; other site 706587007115 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 706587007116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706587007117 NAD(P) binding site [chemical binding]; other site 706587007118 active site 706587007119 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 706587007120 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 706587007121 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 706587007122 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587007123 Cysteine-rich domain; Region: CCG; pfam02754 706587007124 Cysteine-rich domain; Region: CCG; pfam02754 706587007125 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 706587007126 HIT family signature motif; other site 706587007127 catalytic residue [active] 706587007128 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 706587007129 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 706587007130 dimer interface [polypeptide binding]; other site 706587007131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587007132 catalytic residue [active] 706587007133 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 706587007134 Transglycosylase; Region: Transgly; pfam00912 706587007135 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 706587007136 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587007137 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 706587007138 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587007139 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587007140 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 706587007141 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 706587007142 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 706587007143 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587007144 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 706587007145 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587007146 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587007147 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587007148 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 706587007149 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 706587007150 Na binding site [ion binding]; other site 706587007151 Protein of unknown function, DUF485; Region: DUF485; pfam04341 706587007152 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 706587007153 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 706587007154 acyl-activating enzyme (AAE) consensus motif; other site 706587007155 putative AMP binding site [chemical binding]; other site 706587007156 putative active site [active] 706587007157 putative CoA binding site [chemical binding]; other site 706587007158 acetyl-CoA synthetase; Provisional; Region: PRK00174 706587007159 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587007160 acyl-activating enzyme (AAE) consensus motif; other site 706587007161 AMP binding site [chemical binding]; other site 706587007162 active site 706587007163 CoA binding site [chemical binding]; other site 706587007164 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 706587007165 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 706587007166 active site 706587007167 catalytic site [active] 706587007168 substrate binding site [chemical binding]; other site 706587007169 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 706587007170 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706587007171 ligand binding site [chemical binding]; other site 706587007172 flexible hinge region; other site 706587007173 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 706587007174 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 706587007175 metal binding triad; other site 706587007176 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 706587007177 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706587007178 ligand binding site [chemical binding]; other site 706587007179 flexible hinge region; other site 706587007180 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 706587007181 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 706587007182 metal binding triad; other site 706587007183 acetyl-CoA synthetase; Provisional; Region: PRK00174 706587007184 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 706587007185 active site 706587007186 CoA binding site [chemical binding]; other site 706587007187 acyl-activating enzyme (AAE) consensus motif; other site 706587007188 AMP binding site [chemical binding]; other site 706587007189 acetate binding site [chemical binding]; other site 706587007190 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 706587007191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587007192 Coenzyme A binding pocket [chemical binding]; other site 706587007193 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 706587007194 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 706587007195 active site 706587007196 Zn binding site [ion binding]; other site 706587007197 acetyl-CoA synthetase; Provisional; Region: PRK04319 706587007198 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587007199 acyl-activating enzyme (AAE) consensus motif; other site 706587007200 AMP binding site [chemical binding]; other site 706587007201 active site 706587007202 CoA binding site [chemical binding]; other site 706587007203 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 706587007204 substrate binding pocket [chemical binding]; other site 706587007205 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 706587007206 dimer interface [polypeptide binding]; other site 706587007207 inhibitor binding site; inhibition site 706587007208 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 706587007209 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 706587007210 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 706587007211 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 706587007212 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 706587007213 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 706587007214 active site residue [active] 706587007215 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 706587007216 active site residue [active] 706587007217 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 706587007218 active site residue [active] 706587007219 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 706587007220 DHH family; Region: DHH; pfam01368 706587007221 DHHA1 domain; Region: DHHA1; pfam02272 706587007222 FOG: CBS domain [General function prediction only]; Region: COG0517 706587007223 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 706587007224 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 706587007225 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 706587007226 active site 706587007227 NTP binding site [chemical binding]; other site 706587007228 metal binding triad [ion binding]; metal-binding site 706587007229 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 706587007230 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 706587007231 active site 706587007232 catalytic residues [active] 706587007233 metal binding site [ion binding]; metal-binding site 706587007234 homodimer binding site [polypeptide binding]; other site 706587007235 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 706587007236 CoenzymeA binding site [chemical binding]; other site 706587007237 subunit interaction site [polypeptide binding]; other site 706587007238 PHB binding site; other site 706587007239 EamA-like transporter family; Region: EamA; pfam00892 706587007240 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 706587007241 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 706587007242 Staphylococcal nuclease homologues; Region: SNc; smart00318 706587007243 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 706587007244 Catalytic site; other site 706587007245 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 706587007246 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 706587007247 putative DNA binding site [nucleotide binding]; other site 706587007248 putative homodimer interface [polypeptide binding]; other site 706587007249 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 706587007250 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706587007251 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 706587007252 DNA binding residues [nucleotide binding] 706587007253 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 706587007254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587007255 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706587007256 putative substrate translocation pore; other site 706587007257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587007258 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 706587007259 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 706587007260 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 706587007261 active site 706587007262 metal binding site [ion binding]; metal-binding site 706587007263 DNA binding site [nucleotide binding] 706587007264 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 706587007265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587007266 AAA domain; Region: AAA_27; pfam13514 706587007267 Walker A/P-loop; other site 706587007268 ATP binding site [chemical binding]; other site 706587007269 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 706587007270 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 706587007271 Response regulator receiver domain; Region: Response_reg; pfam00072 706587007272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587007273 active site 706587007274 phosphorylation site [posttranslational modification] 706587007275 intermolecular recognition site; other site 706587007276 dimerization interface [polypeptide binding]; other site 706587007277 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587007278 PAS domain; Region: PAS_9; pfam13426 706587007279 putative active site [active] 706587007280 heme pocket [chemical binding]; other site 706587007281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587007282 Zn2+ binding site [ion binding]; other site 706587007283 Mg2+ binding site [ion binding]; other site 706587007284 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 706587007285 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 706587007286 Walker A motif; other site 706587007287 ATP binding site [chemical binding]; other site 706587007288 Walker B motif; other site 706587007289 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 706587007290 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 706587007291 Walker A motif; other site 706587007292 ATP binding site [chemical binding]; other site 706587007293 Walker B motif; other site 706587007294 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 706587007295 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 706587007296 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587007297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587007298 FeS/SAM binding site; other site 706587007299 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 706587007300 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 706587007301 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 706587007302 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 706587007303 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 706587007304 homodimer interface [polypeptide binding]; other site 706587007305 NADP binding site [chemical binding]; other site 706587007306 substrate binding site [chemical binding]; other site 706587007307 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 706587007308 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 706587007309 P-loop; other site 706587007310 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587007311 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 706587007312 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 706587007313 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 706587007314 ligand binding site [chemical binding]; other site 706587007315 NAD binding site [chemical binding]; other site 706587007316 dimerization interface [polypeptide binding]; other site 706587007317 catalytic site [active] 706587007318 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 706587007319 putative L-serine binding site [chemical binding]; other site 706587007320 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 706587007321 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 706587007322 DNA binding residues [nucleotide binding] 706587007323 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 706587007324 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 706587007325 P-loop; other site 706587007326 Magnesium ion binding site [ion binding]; other site 706587007327 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 706587007328 Magnesium ion binding site [ion binding]; other site 706587007329 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 706587007330 substrate binding site [chemical binding]; other site 706587007331 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 706587007332 Methyltransferase domain; Region: Methyltransf_31; pfam13847 706587007333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587007334 S-adenosylmethionine binding site [chemical binding]; other site 706587007335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 706587007336 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 706587007337 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 706587007338 B12 binding domain; Region: B12-binding; pfam02310 706587007339 B12 binding site [chemical binding]; other site 706587007340 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587007341 FeS/SAM binding site; other site 706587007342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706587007343 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 706587007344 NAD(P) binding site [chemical binding]; other site 706587007345 active site 706587007346 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 706587007347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 706587007348 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706587007349 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 706587007350 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 706587007351 catalytic core [active] 706587007352 FOG: CBS domain [General function prediction only]; Region: COG0517 706587007353 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 706587007354 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 706587007355 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587007356 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587007357 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 706587007358 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587007359 catalytic loop [active] 706587007360 iron binding site [ion binding]; other site 706587007361 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587007362 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 706587007363 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 706587007364 PAS domain S-box; Region: sensory_box; TIGR00229 706587007365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587007366 putative active site [active] 706587007367 heme pocket [chemical binding]; other site 706587007368 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 706587007369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587007370 Walker A motif; other site 706587007371 ATP binding site [chemical binding]; other site 706587007372 Walker B motif; other site 706587007373 arginine finger; other site 706587007374 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587007375 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 706587007376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587007377 S-adenosylmethionine binding site [chemical binding]; other site 706587007378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587007379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587007380 ATP binding site [chemical binding]; other site 706587007381 Mg2+ binding site [ion binding]; other site 706587007382 G-X-G motif; other site 706587007383 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587007384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587007385 active site 706587007386 phosphorylation site [posttranslational modification] 706587007387 intermolecular recognition site; other site 706587007388 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587007389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587007390 dimer interface [polypeptide binding]; other site 706587007391 phosphorylation site [posttranslational modification] 706587007392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587007393 ATP binding site [chemical binding]; other site 706587007394 Mg2+ binding site [ion binding]; other site 706587007395 G-X-G motif; other site 706587007396 Sulfatase; Region: Sulfatase; cl17466 706587007397 OsmC-like protein; Region: OsmC; pfam02566 706587007398 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587007399 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587007400 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587007401 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587007402 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587007403 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 706587007404 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 706587007405 Predicted transcriptional regulators [Transcription]; Region: COG1695 706587007406 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 706587007407 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706587007408 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 706587007409 SCP-2 sterol transfer family; Region: SCP2; pfam02036 706587007410 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 706587007411 Predicted membrane protein [Function unknown]; Region: COG1971 706587007412 Domain of unknown function DUF; Region: DUF204; pfam02659 706587007413 Domain of unknown function DUF; Region: DUF204; pfam02659 706587007414 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 706587007415 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 706587007416 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 706587007417 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 706587007418 active site 706587007419 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 706587007420 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 706587007421 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 706587007422 active site 706587007423 ATP binding site [chemical binding]; other site 706587007424 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 706587007425 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 706587007426 active site 706587007427 ATP binding site [chemical binding]; other site 706587007428 substrate binding site [chemical binding]; other site 706587007429 activation loop (A-loop); other site 706587007430 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 706587007431 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 706587007432 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 706587007433 Part of AAA domain; Region: AAA_19; pfam13245 706587007434 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 706587007435 Family description; Region: UvrD_C_2; pfam13538 706587007436 TPR repeat; Region: TPR_11; pfam13414 706587007437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007438 binding surface 706587007439 TPR motif; other site 706587007440 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 706587007441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007442 binding surface 706587007443 TPR motif; other site 706587007444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007445 binding surface 706587007446 TPR motif; other site 706587007447 TPR repeat; Region: TPR_11; pfam13414 706587007448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007449 binding surface 706587007450 TPR motif; other site 706587007451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007452 binding surface 706587007453 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587007454 TPR motif; other site 706587007455 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 706587007456 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 706587007457 putative oxidoreductase; Provisional; Region: PRK12831 706587007458 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587007459 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 706587007460 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 706587007461 FAD binding pocket [chemical binding]; other site 706587007462 FAD binding motif [chemical binding]; other site 706587007463 phosphate binding motif [ion binding]; other site 706587007464 beta-alpha-beta structure motif; other site 706587007465 NAD binding pocket [chemical binding]; other site 706587007466 Iron coordination center [ion binding]; other site 706587007467 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 706587007468 active site 706587007469 oxyanion hole [active] 706587007470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007471 binding surface 706587007472 TPR motif; other site 706587007473 TPR repeat; Region: TPR_11; pfam13414 706587007474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007475 binding surface 706587007476 TPR motif; other site 706587007477 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587007478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007479 binding surface 706587007480 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587007481 TPR motif; other site 706587007482 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 706587007483 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 706587007484 Peptidase family M50; Region: Peptidase_M50; pfam02163 706587007485 active site 706587007486 putative substrate binding region [chemical binding]; other site 706587007487 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 706587007488 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 706587007489 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587007490 Bifunctional nuclease; Region: DNase-RNase; pfam02577 706587007491 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 706587007492 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 706587007493 minor groove reading motif; other site 706587007494 helix-hairpin-helix signature motif; other site 706587007495 substrate binding pocket [chemical binding]; other site 706587007496 active site 706587007497 Uncharacterized conserved protein [Function unknown]; Region: COG0432 706587007498 FOG: CBS domain [General function prediction only]; Region: COG0517 706587007499 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 706587007500 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 706587007501 AIR carboxylase; Region: AIRC; smart01001 706587007502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587007503 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587007504 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 706587007505 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 706587007506 DUF35 OB-fold domain; Region: DUF35; pfam01796 706587007507 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 706587007508 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 706587007509 active site 706587007510 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 706587007511 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 706587007512 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 706587007513 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 706587007514 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587007515 active site 706587007516 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 706587007517 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 706587007518 Radical SAM superfamily; Region: Radical_SAM; pfam04055 706587007519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587007520 FeS/SAM binding site; other site 706587007521 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 706587007522 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 706587007523 active site 706587007524 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 706587007525 Mechanosensitive ion channel; Region: MS_channel; pfam00924 706587007526 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 706587007527 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 706587007528 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 706587007529 catalytic site [active] 706587007530 active site 706587007531 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 706587007532 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 706587007533 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 706587007534 active site 706587007535 catalytic site [active] 706587007536 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 706587007537 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 706587007538 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 706587007539 active site 706587007540 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 706587007541 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 706587007542 putative [Fe4-S4] binding site [ion binding]; other site 706587007543 putative molybdopterin cofactor binding site [chemical binding]; other site 706587007544 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 706587007545 putative molybdopterin cofactor binding site; other site 706587007546 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 706587007547 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 706587007548 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706587007549 catalytic residue [active] 706587007550 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 706587007551 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 706587007552 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 706587007553 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 706587007554 HSP70 interaction site [polypeptide binding]; other site 706587007555 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 706587007556 Zn binding sites [ion binding]; other site 706587007557 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 706587007558 dimer interface [polypeptide binding]; other site 706587007559 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 706587007560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007561 binding surface 706587007562 TPR motif; other site 706587007563 TPR repeat; Region: TPR_11; pfam13414 706587007564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007565 binding surface 706587007566 TPR motif; other site 706587007567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007568 binding surface 706587007569 TPR motif; other site 706587007570 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 706587007571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007572 binding surface 706587007573 TPR motif; other site 706587007574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007575 binding surface 706587007576 TPR motif; other site 706587007577 TPR repeat; Region: TPR_11; pfam13414 706587007578 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 706587007579 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706587007580 active site 706587007581 motif I; other site 706587007582 motif II; other site 706587007583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706587007584 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 706587007585 catalytic residues [active] 706587007586 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 706587007587 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 706587007588 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 706587007589 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 706587007590 Walker A/P-loop; other site 706587007591 ATP binding site [chemical binding]; other site 706587007592 ABC transporter; Region: ABC_tran; pfam00005 706587007593 Q-loop/lid; other site 706587007594 ABC transporter signature motif; other site 706587007595 Walker B; other site 706587007596 D-loop; other site 706587007597 H-loop/switch region; other site 706587007598 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 706587007599 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 706587007600 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587007601 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 706587007602 acyl-activating enzyme (AAE) consensus motif; other site 706587007603 putative AMP binding site [chemical binding]; other site 706587007604 putative active site [active] 706587007605 putative CoA binding site [chemical binding]; other site 706587007606 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 706587007607 A new structural DNA glycosylase; Region: AlkD_like; cd06561 706587007608 active site 706587007609 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 706587007610 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 706587007611 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 706587007612 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 706587007613 Uncharacterized conserved protein [Function unknown]; Region: COG2006 706587007614 Domain of unknown function (DUF362); Region: DUF362; pfam04015 706587007615 Double zinc ribbon; Region: DZR; pfam12773 706587007616 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 706587007617 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587007618 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587007619 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587007620 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587007621 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 706587007622 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 706587007623 dimer interface [polypeptide binding]; other site 706587007624 active site 706587007625 heme binding site [chemical binding]; other site 706587007626 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 706587007627 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587007628 dimer interface [polypeptide binding]; other site 706587007629 phosphorylation site [posttranslational modification] 706587007630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587007631 ATP binding site [chemical binding]; other site 706587007632 Mg2+ binding site [ion binding]; other site 706587007633 G-X-G motif; other site 706587007634 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 706587007635 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 706587007636 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 706587007637 metal binding site [ion binding]; metal-binding site 706587007638 putative dimer interface [polypeptide binding]; other site 706587007639 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587007640 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587007641 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 706587007642 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 706587007643 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 706587007644 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587007645 FOG: CBS domain [General function prediction only]; Region: COG0517 706587007646 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 706587007647 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 706587007648 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 706587007649 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 706587007650 Mechanosensitive ion channel; Region: MS_channel; pfam00924 706587007651 Uncharacterized conserved protein [Function unknown]; Region: COG5361 706587007652 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 706587007653 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 706587007654 MarC family integral membrane protein; Region: MarC; pfam01914 706587007655 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 706587007656 Sulfatase; Region: Sulfatase; pfam00884 706587007657 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 706587007658 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 706587007659 Sulfatase; Region: Sulfatase; pfam00884 706587007660 HEAT repeats; Region: HEAT_2; pfam13646 706587007661 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 706587007662 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706587007663 ligand binding site [chemical binding]; other site 706587007664 flexible hinge region; other site 706587007665 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 706587007666 Sulfatase; Region: Sulfatase; pfam00884 706587007667 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 706587007668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706587007669 motif II; other site 706587007670 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 706587007671 Sulfatase; Region: Sulfatase; pfam00884 706587007672 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 706587007673 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 706587007674 heme-binding residues [chemical binding]; other site 706587007675 HEAT repeats; Region: HEAT_2; pfam13646 706587007676 TPR repeat; Region: TPR_11; pfam13414 706587007677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007678 binding surface 706587007679 TPR motif; other site 706587007680 TPR repeat; Region: TPR_11; pfam13414 706587007681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007682 binding surface 706587007683 TPR motif; other site 706587007684 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587007685 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 706587007686 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706587007687 ATP binding site [chemical binding]; other site 706587007688 putative Mg++ binding site [ion binding]; other site 706587007689 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706587007690 nucleotide binding region [chemical binding]; other site 706587007691 ATP-binding site [chemical binding]; other site 706587007692 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 706587007693 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 706587007694 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 706587007695 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 706587007696 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 706587007697 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706587007698 ligand binding site [chemical binding]; other site 706587007699 flexible hinge region; other site 706587007700 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 706587007701 putative switch regulator; other site 706587007702 non-specific DNA interactions [nucleotide binding]; other site 706587007703 DNA binding site [nucleotide binding] 706587007704 sequence specific DNA binding site [nucleotide binding]; other site 706587007705 putative cAMP binding site [chemical binding]; other site 706587007706 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 706587007707 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587007708 4Fe-4S binding domain; Region: Fer4; pfam00037 706587007709 hybrid cluster protein; Provisional; Region: PRK05290 706587007710 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587007711 ACS interaction site; other site 706587007712 CODH interaction site; other site 706587007713 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 706587007714 hybrid metal cluster; other site 706587007715 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 706587007716 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587007717 Zn2+ binding site [ion binding]; other site 706587007718 Mg2+ binding site [ion binding]; other site 706587007719 Ferredoxin [Energy production and conversion]; Region: COG1146 706587007720 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 706587007721 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 706587007722 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 706587007723 Binuclear center (active site) [active] 706587007724 K-pathway; other site 706587007725 Putative proton exit pathway; other site 706587007726 TraB family; Region: TraB; cl12050 706587007727 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 706587007728 Domain of unknown function DUF39; Region: DUF39; pfam01837 706587007729 hypothetical protein; Provisional; Region: PRK04334 706587007730 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 706587007731 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587007732 4Fe-4S binding domain; Region: Fer4; pfam00037 706587007733 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 706587007734 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 706587007735 CoA-binding site [chemical binding]; other site 706587007736 ATP-binding [chemical binding]; other site 706587007737 Chain length determinant protein; Region: Wzz; pfam02706 706587007738 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 706587007739 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 706587007740 Chain length determinant protein; Region: Wzz; cl15801 706587007741 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587007742 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 706587007743 propionate/acetate kinase; Provisional; Region: PRK12379 706587007744 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 706587007745 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 706587007746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587007747 Walker A motif; other site 706587007748 ATP binding site [chemical binding]; other site 706587007749 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 706587007750 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 706587007751 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 706587007752 active site 706587007753 HslU subunit interaction site [polypeptide binding]; other site 706587007754 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 706587007755 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 706587007756 active site 706587007757 DNA binding site [nucleotide binding] 706587007758 Int/Topo IB signature motif; other site 706587007759 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 706587007760 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 706587007761 Mg++ binding site [ion binding]; other site 706587007762 putative catalytic motif [active] 706587007763 substrate binding site [chemical binding]; other site 706587007764 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 706587007765 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706587007766 active site 706587007767 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 706587007768 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587007769 FtsX-like permease family; Region: FtsX; pfam02687 706587007770 2-ketoisovalerate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11864 706587007771 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 706587007772 TPP-binding site [chemical binding]; other site 706587007773 putative dimer interface [polypeptide binding]; other site 706587007774 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 706587007775 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 706587007776 dimer interface [polypeptide binding]; other site 706587007777 PYR/PP interface [polypeptide binding]; other site 706587007778 TPP binding site [chemical binding]; other site 706587007779 substrate binding site [chemical binding]; other site 706587007780 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706587007781 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 706587007782 4Fe-4S binding domain; Region: Fer4; pfam00037 706587007783 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 706587007784 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 706587007785 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 706587007786 DNA methylase; Region: N6_N4_Mtase; pfam01555 706587007787 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 706587007788 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 706587007789 motif 1; other site 706587007790 active site 706587007791 motif 2; other site 706587007792 motif 3; other site 706587007793 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 706587007794 DHHA1 domain; Region: DHHA1; pfam02272 706587007795 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 706587007796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587007797 binding surface 706587007798 TPR motif; other site 706587007799 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 706587007800 Catalytic domain of Protein Kinases; Region: PKc; cd00180 706587007801 active site 706587007802 ATP binding site [chemical binding]; other site 706587007803 substrate binding site [chemical binding]; other site 706587007804 activation loop (A-loop); other site 706587007805 4Fe-4S binding domain; Region: Fer4_5; pfam12801 706587007806 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 706587007807 4Fe-4S binding domain; Region: Fer4; pfam00037 706587007808 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 706587007809 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587007810 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 706587007811 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 706587007812 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587007813 Uncharacterized conserved protein [Function unknown]; Region: COG2006 706587007814 Domain of unknown function (DUF362); Region: DUF362; pfam04015 706587007815 LemA family; Region: LemA; cl00742 706587007816 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 706587007817 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 706587007818 active site 706587007819 substrate binding site [chemical binding]; other site 706587007820 metal binding site [ion binding]; metal-binding site 706587007821 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 706587007822 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 706587007823 putative active site [active] 706587007824 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 706587007825 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 706587007826 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 706587007827 hypothetical protein; Provisional; Region: PRK11820 706587007828 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 706587007829 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 706587007830 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 706587007831 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 706587007832 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 706587007833 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 706587007834 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 706587007835 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 706587007836 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 706587007837 active site 706587007838 metal binding site [ion binding]; metal-binding site 706587007839 DNA binding site [nucleotide binding] 706587007840 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 706587007841 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 706587007842 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587007843 Walker A/P-loop; other site 706587007844 ATP binding site [chemical binding]; other site 706587007845 Q-loop/lid; other site 706587007846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587007847 ABC transporter signature motif; other site 706587007848 Walker B; other site 706587007849 D-loop; other site 706587007850 H-loop/switch region; other site 706587007851 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 706587007852 B12 binding site [chemical binding]; other site 706587007853 cobalt ligand [ion binding]; other site 706587007854 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587007855 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 706587007856 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 706587007857 competence damage-inducible protein A; Provisional; Region: PRK00549 706587007858 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 706587007859 putative MPT binding site; other site 706587007860 Competence-damaged protein; Region: CinA; pfam02464 706587007861 DNA polymerase I; Provisional; Region: PRK05755 706587007862 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 706587007863 active site 706587007864 metal binding site 1 [ion binding]; metal-binding site 706587007865 putative 5' ssDNA interaction site; other site 706587007866 metal binding site 3; metal-binding site 706587007867 metal binding site 2 [ion binding]; metal-binding site 706587007868 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 706587007869 putative DNA binding site [nucleotide binding]; other site 706587007870 putative metal binding site [ion binding]; other site 706587007871 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 706587007872 active site 706587007873 catalytic site [active] 706587007874 substrate binding site [chemical binding]; other site 706587007875 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 706587007876 active site 706587007877 DNA binding site [nucleotide binding] 706587007878 catalytic site [active] 706587007879 DNA replication factor Dna2; Region: Dna2; pfam08696 706587007880 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 706587007881 AAA domain; Region: AAA_11; pfam13086 706587007882 Part of AAA domain; Region: AAA_19; pfam13245 706587007883 AAA domain; Region: AAA_12; pfam13087 706587007884 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 706587007885 AP (apurinic/apyrimidinic) site pocket; other site 706587007886 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 706587007887 DNA interaction; other site 706587007888 Metal-binding active site; metal-binding site 706587007889 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 706587007890 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587007891 FeS/SAM binding site; other site 706587007892 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 706587007893 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 706587007894 nudix motif; other site 706587007895 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 706587007896 oligomerisation interface [polypeptide binding]; other site 706587007897 mobile loop; other site 706587007898 roof hairpin; other site 706587007899 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 706587007900 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 706587007901 ring oligomerisation interface [polypeptide binding]; other site 706587007902 ATP/Mg binding site [chemical binding]; other site 706587007903 stacking interactions; other site 706587007904 hinge regions; other site 706587007905 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 706587007906 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 706587007907 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 706587007908 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 706587007909 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 706587007910 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 706587007911 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 706587007912 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 706587007913 active site 706587007914 intracellular protease, PfpI family; Region: PfpI; TIGR01382 706587007915 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 706587007916 proposed catalytic triad [active] 706587007917 conserved cys residue [active] 706587007918 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 706587007919 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 706587007920 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 706587007921 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 706587007922 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 706587007923 Walker A motif; other site 706587007924 ATP binding site [chemical binding]; other site 706587007925 Walker B motif; other site 706587007926 Predicted ATPase [General function prediction only]; Region: COG3910 706587007927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 706587007928 Walker A/P-loop; other site 706587007929 ATP binding site [chemical binding]; other site 706587007930 Q-loop/lid; other site 706587007931 ABC transporter signature motif; other site 706587007932 Walker B; other site 706587007933 D-loop; other site 706587007934 H-loop/switch region; other site 706587007935 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587007936 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587007937 putative active site [active] 706587007938 heme pocket [chemical binding]; other site 706587007939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587007940 dimer interface [polypeptide binding]; other site 706587007941 phosphorylation site [posttranslational modification] 706587007942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587007943 ATP binding site [chemical binding]; other site 706587007944 Mg2+ binding site [ion binding]; other site 706587007945 G-X-G motif; other site 706587007946 PAS domain S-box; Region: sensory_box; TIGR00229 706587007947 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587007948 putative active site [active] 706587007949 heme pocket [chemical binding]; other site 706587007950 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706587007951 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706587007952 metal binding site [ion binding]; metal-binding site 706587007953 active site 706587007954 I-site; other site 706587007955 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 706587007956 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 706587007957 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 706587007958 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 706587007959 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 706587007960 tRNA; other site 706587007961 putative tRNA binding site [nucleotide binding]; other site 706587007962 putative NADP binding site [chemical binding]; other site 706587007963 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 706587007964 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 706587007965 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 706587007966 domain interfaces; other site 706587007967 active site 706587007968 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 706587007969 active site 706587007970 SAM binding site [chemical binding]; other site 706587007971 homodimer interface [polypeptide binding]; other site 706587007972 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 706587007973 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 706587007974 active site 706587007975 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587007976 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587007977 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 706587007978 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 706587007979 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 706587007980 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 706587007981 putative metal binding site; other site 706587007982 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 706587007983 OsmC-like protein; Region: OsmC; cl00767 706587007984 OsmC-like protein; Region: OsmC; pfam02566 706587007985 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 706587007986 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 706587007987 PRC-barrel domain; Region: PRC; pfam05239 706587007988 MgtE intracellular N domain; Region: MgtE_N; smart00924 706587007989 FOG: CBS domain [General function prediction only]; Region: COG0517 706587007990 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 706587007991 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 706587007992 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 706587007993 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 706587007994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587007995 S-adenosylmethionine binding site [chemical binding]; other site 706587007996 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 706587007997 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 706587007998 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587007999 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 706587008000 L-aspartate oxidase; Provisional; Region: PRK06175 706587008001 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 706587008002 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 706587008003 dimer interface [polypeptide binding]; other site 706587008004 Citrate synthase; Region: Citrate_synt; pfam00285 706587008005 active site 706587008006 citrylCoA binding site [chemical binding]; other site 706587008007 oxalacetate/citrate binding site [chemical binding]; other site 706587008008 coenzyme A binding site [chemical binding]; other site 706587008009 catalytic triad [active] 706587008010 Rubrerythrin [Energy production and conversion]; Region: COG1592 706587008011 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 706587008012 binuclear metal center [ion binding]; other site 706587008013 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 706587008014 iron binding site [ion binding]; other site 706587008015 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 706587008016 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 706587008017 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 706587008018 Part of AAA domain; Region: AAA_19; pfam13245 706587008019 Family description; Region: UvrD_C_2; pfam13538 706587008020 HEAT repeats; Region: HEAT_2; pfam13646 706587008021 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 706587008022 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706587008023 ligand binding site [chemical binding]; other site 706587008024 flexible hinge region; other site 706587008025 PAS domain; Region: PAS_9; pfam13426 706587008026 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587008027 putative active site [active] 706587008028 heme pocket [chemical binding]; other site 706587008029 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587008030 Zn2+ binding site [ion binding]; other site 706587008031 Mg2+ binding site [ion binding]; other site 706587008032 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 706587008033 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 706587008034 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 706587008035 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 706587008036 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 706587008037 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 706587008038 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 706587008039 ResB-like family; Region: ResB; pfam05140 706587008040 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 706587008041 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 706587008042 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 706587008043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587008044 PAS domain; Region: PAS_9; pfam13426 706587008045 putative active site [active] 706587008046 heme pocket [chemical binding]; other site 706587008047 PAS domain S-box; Region: sensory_box; TIGR00229 706587008048 sensory histidine kinase AtoS; Provisional; Region: PRK11360 706587008049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587008050 dimer interface [polypeptide binding]; other site 706587008051 phosphorylation site [posttranslational modification] 706587008052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587008053 ATP binding site [chemical binding]; other site 706587008054 Mg2+ binding site [ion binding]; other site 706587008055 G-X-G motif; other site 706587008056 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587008057 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587008058 dimer interface [polypeptide binding]; other site 706587008059 phosphorylation site [posttranslational modification] 706587008060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587008061 ATP binding site [chemical binding]; other site 706587008062 Mg2+ binding site [ion binding]; other site 706587008063 G-X-G motif; other site 706587008064 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587008065 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 706587008066 catalytic loop [active] 706587008067 iron binding site [ion binding]; other site 706587008068 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 706587008069 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 706587008070 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 706587008071 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 706587008072 B12 binding site [chemical binding]; other site 706587008073 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 706587008074 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587008075 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587008076 4Fe-4S binding domain; Region: Fer4; pfam00037 706587008077 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 706587008078 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 706587008079 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 706587008080 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 706587008081 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 706587008082 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 706587008083 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 706587008084 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 706587008085 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 706587008086 Protein of unknown function DUF58; Region: DUF58; pfam01882 706587008087 MoxR-like ATPases [General function prediction only]; Region: COG0714 706587008088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587008089 Walker A motif; other site 706587008090 ATP binding site [chemical binding]; other site 706587008091 Walker B motif; other site 706587008092 arginine finger; other site 706587008093 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706587008094 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587008095 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587008096 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 706587008097 Protein export membrane protein; Region: SecD_SecF; cl14618 706587008098 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 706587008099 active site 706587008100 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 706587008101 putative RNAase interaction site [polypeptide binding]; other site 706587008102 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 706587008103 putative active site pocket [active] 706587008104 cleavage site 706587008105 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 706587008106 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 706587008107 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 706587008108 putative catalytic site [active] 706587008109 putative metal binding site [ion binding]; other site 706587008110 putative phosphate binding site [ion binding]; other site 706587008111 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 706587008112 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 706587008113 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 706587008114 putative active site [active] 706587008115 putative active site [active] 706587008116 catalytic site [active] 706587008117 catalytic site [active] 706587008118 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 706587008119 putative active site [active] 706587008120 catalytic site [active] 706587008121 Uncharacterized conserved protein [Function unknown]; Region: COG0398 706587008122 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 706587008123 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 706587008124 non-heme iron binding site [ion binding]; other site 706587008125 tetramer interface [polypeptide binding]; other site 706587008126 AMIN domain; Region: AMIN; pfam11741 706587008127 Uncharacterized conserved protein [Function unknown]; Region: COG2006 706587008128 Domain of unknown function (DUF362); Region: DUF362; pfam04015 706587008129 Protein of unknown function DUF72; Region: DUF72; pfam01904 706587008130 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 706587008131 active site residue [active] 706587008132 HEAT repeats; Region: HEAT_2; pfam13646 706587008133 HEAT repeats; Region: HEAT_2; pfam13646 706587008134 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 706587008135 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 706587008136 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 706587008137 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587008138 Cysteine-rich domain; Region: CCG; pfam02754 706587008139 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 706587008140 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 706587008141 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706587008142 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 706587008143 Zn binding site [ion binding]; other site 706587008144 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 706587008145 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 706587008146 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 706587008147 Part of AAA domain; Region: AAA_19; pfam13245 706587008148 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 706587008149 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 706587008150 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706587008151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587008152 homodimer interface [polypeptide binding]; other site 706587008153 catalytic residue [active] 706587008154 TraB family; Region: TraB; pfam01963 706587008155 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587008156 FeS/SAM binding site; other site 706587008157 Radical SAM superfamily; Region: Radical_SAM; pfam04055 706587008158 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 706587008159 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 706587008160 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 706587008161 putative [Fe4-S4] binding site [ion binding]; other site 706587008162 putative molybdopterin cofactor binding site [chemical binding]; other site 706587008163 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 706587008164 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 706587008165 putative molybdopterin cofactor binding site; other site 706587008166 Protein of unknown function DUF262; Region: DUF262; pfam03235 706587008167 DNA methylase; Region: N6_N4_Mtase; cl17433 706587008168 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 706587008169 nucleoside/Zn binding site; other site 706587008170 dimer interface [polypeptide binding]; other site 706587008171 catalytic motif [active] 706587008172 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 706587008173 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 706587008174 nudix motif; other site 706587008175 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PRK04207 706587008176 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742 706587008177 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 706587008178 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 706587008179 homodimer interface [polypeptide binding]; other site 706587008180 oligonucleotide binding site [chemical binding]; other site 706587008181 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 706587008182 G1 box; other site 706587008183 GTP/Mg2+ binding site [chemical binding]; other site 706587008184 Switch I region; other site 706587008185 G2 box; other site 706587008186 G3 box; other site 706587008187 Switch II region; other site 706587008188 G4 box; other site 706587008189 G5 box; other site 706587008190 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 706587008191 homotrimer interaction site [polypeptide binding]; other site 706587008192 putative active site [active] 706587008193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587008194 FeS/SAM binding site; other site 706587008195 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 706587008196 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 706587008197 DNA binding site [nucleotide binding] 706587008198 active site 706587008199 6-phosphofructokinase; Provisional; Region: PRK14072 706587008200 active site 706587008201 ADP/pyrophosphate binding site [chemical binding]; other site 706587008202 dimerization interface [polypeptide binding]; other site 706587008203 allosteric effector site; other site 706587008204 fructose-1,6-bisphosphate binding site; other site 706587008205 Condensation domain; Region: Condensation; pfam00668 706587008206 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 706587008207 putative ADP-binding pocket [chemical binding]; other site 706587008208 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587008209 Cupin domain; Region: Cupin_2; cl17218 706587008210 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587008211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 706587008212 active site 706587008213 phosphorylation site [posttranslational modification] 706587008214 intermolecular recognition site; other site 706587008215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587008216 dimer interface [polypeptide binding]; other site 706587008217 phosphorylation site [posttranslational modification] 706587008218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587008219 ATP binding site [chemical binding]; other site 706587008220 Mg2+ binding site [ion binding]; other site 706587008221 G-X-G motif; other site 706587008222 Response regulator receiver domain; Region: Response_reg; pfam00072 706587008223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587008224 active site 706587008225 phosphorylation site [posttranslational modification] 706587008226 intermolecular recognition site; other site 706587008227 dimerization interface [polypeptide binding]; other site 706587008228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587008229 dimer interface [polypeptide binding]; other site 706587008230 phosphorylation site [posttranslational modification] 706587008231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587008232 ATP binding site [chemical binding]; other site 706587008233 Mg2+ binding site [ion binding]; other site 706587008234 G-X-G motif; other site 706587008235 Response regulator receiver domain; Region: Response_reg; pfam00072 706587008236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587008237 active site 706587008238 phosphorylation site [posttranslational modification] 706587008239 intermolecular recognition site; other site 706587008240 dimerization interface [polypeptide binding]; other site 706587008241 PAS domain S-box; Region: sensory_box; TIGR00229 706587008242 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587008243 putative active site [active] 706587008244 heme pocket [chemical binding]; other site 706587008245 PAS domain S-box; Region: sensory_box; TIGR00229 706587008246 PAS domain; Region: PAS_8; pfam13188 706587008247 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 706587008248 Histidine kinase; Region: HisKA_2; pfam07568 706587008249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587008250 ATP binding site [chemical binding]; other site 706587008251 Mg2+ binding site [ion binding]; other site 706587008252 G-X-G motif; other site 706587008253 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587008254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587008255 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587008256 Methyltransferase domain; Region: Methyltransf_11; pfam08241 706587008257 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 706587008258 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 706587008259 putative acyl-acceptor binding pocket; other site 706587008260 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706587008261 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587008262 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587008263 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 706587008264 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 706587008265 Walker A/P-loop; other site 706587008266 ATP binding site [chemical binding]; other site 706587008267 Q-loop/lid; other site 706587008268 ABC transporter signature motif; other site 706587008269 Walker B; other site 706587008270 D-loop; other site 706587008271 H-loop/switch region; other site 706587008272 PAC2 family; Region: PAC2; pfam09754 706587008273 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 706587008274 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 706587008275 Ligand Binding Site [chemical binding]; other site 706587008276 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 706587008277 Transglycosylase; Region: Transgly; pfam00912 706587008278 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 706587008279 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 706587008280 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 706587008281 DXD motif; other site 706587008282 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 706587008283 putative active site pocket [active] 706587008284 dimerization interface [polypeptide binding]; other site 706587008285 putative catalytic residue [active] 706587008286 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 706587008287 B3/4 domain; Region: B3_4; pfam03483 706587008288 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 706587008289 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 706587008290 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 706587008291 DNA polymerase III, delta subunit; Region: holA; TIGR01128 706587008292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587008293 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587008294 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 706587008295 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 706587008296 cobalamin synthase; Reviewed; Region: cobS; PRK00235 706587008297 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 706587008298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706587008299 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 706587008300 NAD(P) binding site [chemical binding]; other site 706587008301 active site 706587008302 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 706587008303 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 706587008304 NAD binding site [chemical binding]; other site 706587008305 homodimer interface [polypeptide binding]; other site 706587008306 active site 706587008307 substrate binding site [chemical binding]; other site 706587008308 enolase; Provisional; Region: eno; PRK00077 706587008309 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 706587008310 dimer interface [polypeptide binding]; other site 706587008311 metal binding site [ion binding]; metal-binding site 706587008312 substrate binding pocket [chemical binding]; other site 706587008313 DRTGG domain; Region: DRTGG; pfam07085 706587008314 FOG: CBS domain [General function prediction only]; Region: COG0517 706587008315 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 706587008316 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 706587008317 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 706587008318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587008319 ATP binding site [chemical binding]; other site 706587008320 Mg2+ binding site [ion binding]; other site 706587008321 G-X-G motif; other site 706587008322 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 706587008323 NADH dehydrogenase subunit B; Validated; Region: PRK06411 706587008324 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 706587008325 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 706587008326 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 706587008327 NADH dehydrogenase subunit D; Validated; Region: PRK06075 706587008328 DRTGG domain; Region: DRTGG; pfam07085 706587008329 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 706587008330 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 706587008331 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 706587008332 PHP-associated; Region: PHP_C; pfam13263 706587008333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587008334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587008335 ATP binding site [chemical binding]; other site 706587008336 G-X-G motif; other site 706587008337 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 706587008338 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 706587008339 putative dimer interface [polypeptide binding]; other site 706587008340 [2Fe-2S] cluster binding site [ion binding]; other site 706587008341 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 706587008342 dimer interface [polypeptide binding]; other site 706587008343 [2Fe-2S] cluster binding site [ion binding]; other site 706587008344 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 706587008345 dimer interface [polypeptide binding]; other site 706587008346 [2Fe-2S] cluster binding site [ion binding]; other site 706587008347 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 706587008348 SLBB domain; Region: SLBB; pfam10531 706587008349 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 706587008350 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 706587008351 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 706587008352 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 706587008353 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587008354 catalytic loop [active] 706587008355 iron binding site [ion binding]; other site 706587008356 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 706587008357 4Fe-4S binding domain; Region: Fer4_6; pfam12837 706587008358 4Fe-4S binding domain; Region: Fer4; pfam00037 706587008359 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 706587008360 molybdopterin cofactor binding site; other site 706587008361 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 706587008362 molybdopterin cofactor binding site; other site 706587008363 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 706587008364 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 706587008365 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 706587008366 4Fe-4S binding domain; Region: Fer4; pfam00037 706587008367 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499 706587008368 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 706587008369 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 706587008370 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 706587008371 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 706587008372 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 706587008373 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 706587008374 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 706587008375 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 706587008376 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 706587008377 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 706587008378 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 706587008379 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 706587008380 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 706587008381 conserved cys residue [active] 706587008382 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 706587008383 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 706587008384 Potassium binding sites [ion binding]; other site 706587008385 Cesium cation binding sites [ion binding]; other site 706587008386 pantothenate kinase; Reviewed; Region: PRK13318 706587008387 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 706587008388 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 706587008389 active site 706587008390 Zn binding site [ion binding]; other site 706587008391 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 706587008392 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 706587008393 RNA binding site [nucleotide binding]; other site 706587008394 active site 706587008395 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 706587008396 conserved cys residue [active] 706587008397 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 706587008398 CoenzymeA binding site [chemical binding]; other site 706587008399 subunit interaction site [polypeptide binding]; other site 706587008400 PHB binding site; other site 706587008401 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587008402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587008403 active site 706587008404 phosphorylation site [posttranslational modification] 706587008405 intermolecular recognition site; other site 706587008406 dimerization interface [polypeptide binding]; other site 706587008407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587008408 Walker A motif; other site 706587008409 ATP binding site [chemical binding]; other site 706587008410 Walker B motif; other site 706587008411 arginine finger; other site 706587008412 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587008413 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 706587008414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587008415 Coenzyme A binding pocket [chemical binding]; other site 706587008416 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 706587008417 putative amphipathic alpha helix; other site 706587008418 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 706587008419 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 706587008420 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 706587008421 DctM-like transporters; Region: DctM; pfam06808 706587008422 Response regulator receiver domain; Region: Response_reg; pfam00072 706587008423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587008424 active site 706587008425 phosphorylation site [posttranslational modification] 706587008426 intermolecular recognition site; other site 706587008427 dimerization interface [polypeptide binding]; other site 706587008428 Ycf46; Provisional; Region: ycf46; CHL00195 706587008429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587008430 Walker A motif; other site 706587008431 ATP binding site [chemical binding]; other site 706587008432 Walker B motif; other site 706587008433 arginine finger; other site 706587008434 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 706587008435 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587008436 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587008437 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587008438 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587008439 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 706587008440 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 706587008441 active site 706587008442 Zn binding site [ion binding]; other site 706587008443 TPR repeat; Region: TPR_11; pfam13414 706587008444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008445 binding surface 706587008446 TPR motif; other site 706587008447 TPR repeat; Region: TPR_11; pfam13414 706587008448 Tetratricopeptide repeat; Region: TPR_1; pfam00515 706587008449 TPR repeat; Region: TPR_11; pfam13414 706587008450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008451 binding surface 706587008452 TPR motif; other site 706587008453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008454 TPR motif; other site 706587008455 TPR repeat; Region: TPR_11; pfam13414 706587008456 binding surface 706587008457 TPR repeat; Region: TPR_11; pfam13414 706587008458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008459 binding surface 706587008460 TPR motif; other site 706587008461 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 706587008462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008463 binding surface 706587008464 TPR motif; other site 706587008465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008466 binding surface 706587008467 TPR motif; other site 706587008468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008469 binding surface 706587008470 TPR motif; other site 706587008471 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 706587008472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008473 binding surface 706587008474 TPR motif; other site 706587008475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008476 binding surface 706587008477 TPR motif; other site 706587008478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008479 binding surface 706587008480 TPR motif; other site 706587008481 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 706587008482 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 706587008483 G1 box; other site 706587008484 GTP/Mg2+ binding site [chemical binding]; other site 706587008485 G2 box; other site 706587008486 Switch I region; other site 706587008487 G3 box; other site 706587008488 Switch II region; other site 706587008489 G4 box; other site 706587008490 G5 box; other site 706587008491 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 706587008492 putative ADP-ribose binding site [chemical binding]; other site 706587008493 putative active site [active] 706587008494 PBP superfamily domain; Region: PBP_like_2; cl17296 706587008495 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 706587008496 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 706587008497 acyl-activating enzyme (AAE) consensus motif; other site 706587008498 putative AMP binding site [chemical binding]; other site 706587008499 putative active site [active] 706587008500 putative CoA binding site [chemical binding]; other site 706587008501 succinylarginine dihydrolase; Provisional; Region: PRK13281 706587008502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008503 binding surface 706587008504 TPR motif; other site 706587008505 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587008506 TPR repeat; Region: TPR_11; pfam13414 706587008507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008508 binding surface 706587008509 TPR motif; other site 706587008510 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587008511 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 706587008512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587008513 Walker A motif; other site 706587008514 ATP binding site [chemical binding]; other site 706587008515 Walker B motif; other site 706587008516 arginine finger; other site 706587008517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587008518 Walker A motif; other site 706587008519 ATP binding site [chemical binding]; other site 706587008520 Walker B motif; other site 706587008521 arginine finger; other site 706587008522 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 706587008523 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 706587008524 IHF dimer interface [polypeptide binding]; other site 706587008525 IHF - DNA interface [nucleotide binding]; other site 706587008526 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 706587008527 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 706587008528 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587008529 FeS/SAM binding site; other site 706587008530 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 706587008531 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 706587008532 Ligand Binding Site [chemical binding]; other site 706587008533 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 706587008534 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 706587008535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587008536 Walker A/P-loop; other site 706587008537 ATP binding site [chemical binding]; other site 706587008538 Q-loop/lid; other site 706587008539 ABC transporter signature motif; other site 706587008540 Walker B; other site 706587008541 D-loop; other site 706587008542 H-loop/switch region; other site 706587008543 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 706587008544 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 706587008545 active site 706587008546 dimer interface [polypeptide binding]; other site 706587008547 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 706587008548 Ligand Binding Site [chemical binding]; other site 706587008549 Molecular Tunnel; other site 706587008550 Bacterial sugar transferase; Region: Bac_transf; pfam02397 706587008551 Methyltransferase domain; Region: Methyltransf_31; pfam13847 706587008552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587008553 S-adenosylmethionine binding site [chemical binding]; other site 706587008554 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 706587008555 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 706587008556 putative active site [active] 706587008557 putative catalytic site [active] 706587008558 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 706587008559 putative ADP-binding pocket [chemical binding]; other site 706587008560 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587008561 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 706587008562 putative active site [active] 706587008563 putative cosubstrate binding site; other site 706587008564 putative substrate binding site [chemical binding]; other site 706587008565 catalytic site [active] 706587008566 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 706587008567 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 706587008568 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706587008569 active site 706587008570 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 706587008571 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 706587008572 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587008573 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 706587008574 putative ADP-binding pocket [chemical binding]; other site 706587008575 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 706587008576 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706587008577 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 706587008578 ligand binding site; other site 706587008579 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 706587008580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706587008581 NAD(P) binding site [chemical binding]; other site 706587008582 active site 706587008583 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 706587008584 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 706587008585 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 706587008586 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 706587008587 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 706587008588 inhibitor-cofactor binding pocket; inhibition site 706587008589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587008590 catalytic residue [active] 706587008591 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 706587008592 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 706587008593 NAD(P) binding site [chemical binding]; other site 706587008594 homodimer interface [polypeptide binding]; other site 706587008595 substrate binding site [chemical binding]; other site 706587008596 active site 706587008597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587008598 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587008599 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 706587008600 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 706587008601 putative trimer interface [polypeptide binding]; other site 706587008602 putative CoA binding site [chemical binding]; other site 706587008603 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 706587008604 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 706587008605 inhibitor-cofactor binding pocket; inhibition site 706587008606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587008607 catalytic residue [active] 706587008608 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 706587008609 Ferredoxin [Energy production and conversion]; Region: COG1146 706587008610 4Fe-4S binding domain; Region: Fer4; pfam00037 706587008611 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 706587008612 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 706587008613 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 706587008614 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 706587008615 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 706587008616 active site 706587008617 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 706587008618 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 706587008619 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 706587008620 putative active site [active] 706587008621 Uncharacterized conserved protein [Function unknown]; Region: COG2835 706587008622 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706587008623 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 706587008624 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 706587008625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587008626 dimer interface [polypeptide binding]; other site 706587008627 conserved gate region; other site 706587008628 putative PBP binding loops; other site 706587008629 ABC-ATPase subunit interface; other site 706587008630 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 706587008631 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 706587008632 Walker A/P-loop; other site 706587008633 ATP binding site [chemical binding]; other site 706587008634 Q-loop/lid; other site 706587008635 ABC transporter signature motif; other site 706587008636 Walker B; other site 706587008637 D-loop; other site 706587008638 H-loop/switch region; other site 706587008639 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 706587008640 NMT1-like family; Region: NMT1_2; pfam13379 706587008641 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 706587008642 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 706587008643 homodimer interface [polypeptide binding]; other site 706587008644 substrate-cofactor binding pocket; other site 706587008645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587008646 catalytic residue [active] 706587008647 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 706587008648 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 706587008649 conserved cys residue [active] 706587008650 conserved cys residue [active] 706587008651 Ion channel; Region: Ion_trans_2; pfam07885 706587008652 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 706587008653 TrkA-N domain; Region: TrkA_N; pfam02254 706587008654 TrkA-C domain; Region: TrkA_C; pfam02080 706587008655 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 706587008656 active site 706587008657 UGMP family protein; Validated; Region: PRK09604 706587008658 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 706587008659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587008660 Walker A motif; other site 706587008661 ATP binding site [chemical binding]; other site 706587008662 Walker B motif; other site 706587008663 arginine finger; other site 706587008664 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 706587008665 ABC-2 type transporter; Region: ABC2_membrane; cl17235 706587008666 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 706587008667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587008668 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 706587008669 Walker A/P-loop; other site 706587008670 ATP binding site [chemical binding]; other site 706587008671 Q-loop/lid; other site 706587008672 ABC transporter signature motif; other site 706587008673 Walker B; other site 706587008674 D-loop; other site 706587008675 H-loop/switch region; other site 706587008676 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 706587008677 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 706587008678 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 706587008679 RNA binding site [nucleotide binding]; other site 706587008680 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 706587008681 RNA binding site [nucleotide binding]; other site 706587008682 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 706587008683 RNA binding site [nucleotide binding]; other site 706587008684 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 706587008685 RNA binding site [nucleotide binding]; other site 706587008686 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 706587008687 RNA binding site [nucleotide binding]; other site 706587008688 Interleukin 10; Region: IL10; cl02501 706587008689 nickel responsive regulator; Provisional; Region: PRK04460 706587008690 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 706587008691 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 706587008692 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706587008693 dimerization interface [polypeptide binding]; other site 706587008694 putative DNA binding site [nucleotide binding]; other site 706587008695 putative Zn2+ binding site [ion binding]; other site 706587008696 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 706587008697 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 706587008698 catalytic residues [active] 706587008699 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 706587008700 Uncharacterized conserved protein [Function unknown]; Region: COG2006 706587008701 Domain of unknown function (DUF362); Region: DUF362; pfam04015 706587008702 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 706587008703 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 706587008704 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 706587008705 CHAT domain; Region: CHAT; cl17868 706587008706 HD domain; Region: HD_3; pfam13023 706587008707 Methyltransferase domain; Region: Methyltransf_23; pfam13489 706587008708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587008709 S-adenosylmethionine binding site [chemical binding]; other site 706587008710 Protein of unknown function, DUF399; Region: DUF399; pfam04187 706587008711 Acylphosphatase; Region: Acylphosphatase; pfam00708 706587008712 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 706587008713 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 706587008714 nucleotide binding pocket [chemical binding]; other site 706587008715 K-X-D-G motif; other site 706587008716 catalytic site [active] 706587008717 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 706587008718 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 706587008719 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 706587008720 Dimer interface [polypeptide binding]; other site 706587008721 BRCT sequence motif; other site 706587008722 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 706587008723 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 706587008724 Archaebacterial flagellin; Region: Arch_flagellin; cl00732 706587008725 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587008726 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587008727 Walker A/P-loop; other site 706587008728 ATP binding site [chemical binding]; other site 706587008729 Q-loop/lid; other site 706587008730 ABC transporter signature motif; other site 706587008731 Walker B; other site 706587008732 D-loop; other site 706587008733 H-loop/switch region; other site 706587008734 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587008735 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587008736 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587008737 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587008738 TM-ABC transporter signature motif; other site 706587008739 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587008740 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587008741 TM-ABC transporter signature motif; other site 706587008742 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 706587008743 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587008744 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 706587008745 acyl-activating enzyme (AAE) consensus motif; other site 706587008746 putative AMP binding site [chemical binding]; other site 706587008747 putative active site [active] 706587008748 putative CoA binding site [chemical binding]; other site 706587008749 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587008750 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587008751 Walker A/P-loop; other site 706587008752 ATP binding site [chemical binding]; other site 706587008753 Q-loop/lid; other site 706587008754 ABC transporter signature motif; other site 706587008755 Walker B; other site 706587008756 D-loop; other site 706587008757 H-loop/switch region; other site 706587008758 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587008759 enoyl-CoA hydratase; Provisional; Region: PRK07657 706587008760 substrate binding site [chemical binding]; other site 706587008761 oxyanion hole (OAH) forming residues; other site 706587008762 trimer interface [polypeptide binding]; other site 706587008763 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 706587008764 active site 706587008765 catalytic residues [active] 706587008766 metal binding site [ion binding]; metal-binding site 706587008767 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 706587008768 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 706587008769 acyl-activating enzyme (AAE) consensus motif; other site 706587008770 putative AMP binding site [chemical binding]; other site 706587008771 putative active site [active] 706587008772 putative CoA binding site [chemical binding]; other site 706587008773 PLD-like domain; Region: PLDc_2; pfam13091 706587008774 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 706587008775 putative active site [active] 706587008776 catalytic site [active] 706587008777 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 706587008778 SLBB domain; Region: SLBB; pfam10531 706587008779 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587008780 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 706587008781 FMN-binding domain; Region: FMN_bind; cl01081 706587008782 electron transport complex RsxE subunit; Provisional; Region: PRK12405 706587008783 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 706587008784 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587008785 Flagellin N-methylase; Region: FliB; pfam03692 706587008786 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 706587008787 histidinol dehydrogenase; Region: hisD; TIGR00069 706587008788 NAD binding site [chemical binding]; other site 706587008789 dimerization interface [polypeptide binding]; other site 706587008790 product binding site; other site 706587008791 substrate binding site [chemical binding]; other site 706587008792 zinc binding site [ion binding]; other site 706587008793 catalytic residues [active] 706587008794 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 706587008795 trimer interface [polypeptide binding]; other site 706587008796 dimer interface [polypeptide binding]; other site 706587008797 putative active site [active] 706587008798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008799 binding surface 706587008800 TPR repeat; Region: TPR_11; pfam13414 706587008801 TPR motif; other site 706587008802 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587008803 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587008804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008805 binding surface 706587008806 TPR motif; other site 706587008807 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587008808 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587008809 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 706587008810 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 706587008811 SLBB domain; Region: SLBB; pfam10531 706587008812 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 706587008813 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 706587008814 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 706587008815 Peptidase family M48; Region: Peptidase_M48; pfam01435 706587008816 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 706587008817 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 706587008818 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 706587008819 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 706587008820 rRNA binding site [nucleotide binding]; other site 706587008821 predicted 30S ribosome binding site; other site 706587008822 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 706587008823 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 706587008824 Ligand binding site; other site 706587008825 oligomer interface; other site 706587008826 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 706587008827 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 706587008828 inhibitor-cofactor binding pocket; inhibition site 706587008829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587008830 catalytic residue [active] 706587008831 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 706587008832 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 706587008833 active site 706587008834 NAD binding site [chemical binding]; other site 706587008835 metal binding site [ion binding]; metal-binding site 706587008836 glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316 706587008837 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587008838 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 706587008839 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587008840 catalytic loop [active] 706587008841 iron binding site [ion binding]; other site 706587008842 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 706587008843 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 706587008844 molybdopterin cofactor binding site; other site 706587008845 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 706587008846 molybdopterin cofactor binding site; other site 706587008847 Response regulator receiver domain; Region: Response_reg; pfam00072 706587008848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587008849 active site 706587008850 phosphorylation site [posttranslational modification] 706587008851 intermolecular recognition site; other site 706587008852 dimerization interface [polypeptide binding]; other site 706587008853 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706587008854 GAF domain; Region: GAF; pfam01590 706587008855 Response regulator receiver domain; Region: Response_reg; pfam00072 706587008856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587008857 active site 706587008858 phosphorylation site [posttranslational modification] 706587008859 intermolecular recognition site; other site 706587008860 dimerization interface [polypeptide binding]; other site 706587008861 GAF domain; Region: GAF_2; pfam13185 706587008862 GAF domain; Region: GAF; pfam01590 706587008863 signal recognition particle protein; Provisional; Region: PRK10867 706587008864 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 706587008865 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 706587008866 P loop; other site 706587008867 GTP binding site [chemical binding]; other site 706587008868 Signal peptide binding domain; Region: SRP_SPB; pfam02978 706587008869 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 706587008870 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 706587008871 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 706587008872 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 706587008873 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 706587008874 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 706587008875 GatB domain; Region: GatB_Yqey; smart00845 706587008876 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587008877 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587008878 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587008879 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587008880 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587008881 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587008882 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587008883 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587008884 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587008885 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 706587008886 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 706587008887 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 706587008888 FAD binding site [chemical binding]; other site 706587008889 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 706587008890 phosphate binding site [ion binding]; other site 706587008891 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 706587008892 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 706587008893 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 706587008894 active site 706587008895 FMN binding site [chemical binding]; other site 706587008896 substrate binding site [chemical binding]; other site 706587008897 3Fe-4S cluster binding site [ion binding]; other site 706587008898 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 706587008899 active site 706587008900 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 706587008901 domain_subunit interface; other site 706587008902 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587008903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587008904 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587008905 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587008906 substrate binding site [chemical binding]; other site 706587008907 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 706587008908 oxyanion hole (OAH) forming residues; other site 706587008909 trimer interface [polypeptide binding]; other site 706587008910 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 706587008911 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 706587008912 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 706587008913 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 706587008914 dimer interface [polypeptide binding]; other site 706587008915 active site 706587008916 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 706587008917 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 706587008918 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587008919 active site 706587008920 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 706587008921 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587008922 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 706587008923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587008924 FeS/SAM binding site; other site 706587008925 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 706587008926 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 706587008927 dimer interface [polypeptide binding]; other site 706587008928 active site 706587008929 Schiff base residues; other site 706587008930 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 706587008931 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 706587008932 GIY-YIG motif/motif A; other site 706587008933 putative active site [active] 706587008934 putative metal binding site [ion binding]; other site 706587008935 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 706587008936 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 706587008937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587008938 Methyltransferase domain; Region: Methyltransf_31; pfam13847 706587008939 S-adenosylmethionine binding site [chemical binding]; other site 706587008940 Cupin domain; Region: Cupin_2; pfam07883 706587008941 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 706587008942 Clp amino terminal domain; Region: Clp_N; pfam02861 706587008943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587008944 Walker A motif; other site 706587008945 ATP binding site [chemical binding]; other site 706587008946 Walker B motif; other site 706587008947 arginine finger; other site 706587008948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587008949 Walker A motif; other site 706587008950 ATP binding site [chemical binding]; other site 706587008951 Walker B motif; other site 706587008952 arginine finger; other site 706587008953 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 706587008954 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 706587008955 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 706587008956 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706587008957 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 706587008958 dimer interface [polypeptide binding]; other site 706587008959 substrate binding site [chemical binding]; other site 706587008960 metal binding site [ion binding]; metal-binding site 706587008961 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 706587008962 carboxyltransferase (CT) interaction site; other site 706587008963 biotinylation site [posttranslational modification]; other site 706587008964 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 706587008965 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 706587008966 active site 706587008967 FMN binding site [chemical binding]; other site 706587008968 substrate binding site [chemical binding]; other site 706587008969 putative catalytic residue [active] 706587008970 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 706587008971 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 706587008972 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 706587008973 TPR repeat; Region: TPR_11; pfam13414 706587008974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008975 binding surface 706587008976 TPR motif; other site 706587008977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008978 TPR motif; other site 706587008979 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587008980 binding surface 706587008981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587008982 binding surface 706587008983 TPR repeat; Region: TPR_11; pfam13414 706587008984 TPR motif; other site 706587008985 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587008986 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 706587008987 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 706587008988 Walker A/P-loop; other site 706587008989 ATP binding site [chemical binding]; other site 706587008990 Q-loop/lid; other site 706587008991 ABC transporter signature motif; other site 706587008992 Walker B; other site 706587008993 D-loop; other site 706587008994 H-loop/switch region; other site 706587008995 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 706587008996 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 706587008997 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 706587008998 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 706587008999 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 706587009000 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 706587009001 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 706587009002 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 706587009003 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 706587009004 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706587009005 catalytic residue [active] 706587009006 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 706587009007 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 706587009008 trimerization site [polypeptide binding]; other site 706587009009 active site 706587009010 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 706587009011 NifU-like domain; Region: NifU; cl00484 706587009012 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 706587009013 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 706587009014 active site 706587009015 Zn binding site [ion binding]; other site 706587009016 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587009017 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 706587009018 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 706587009019 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 706587009020 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 706587009021 putative NAD(P) binding site [chemical binding]; other site 706587009022 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 706587009023 RibD C-terminal domain; Region: RibD_C; cl17279 706587009024 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 706587009025 aspartate kinase; Reviewed; Region: PRK06635 706587009026 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 706587009027 putative nucleotide binding site [chemical binding]; other site 706587009028 putative catalytic residues [active] 706587009029 putative Mg ion binding site [ion binding]; other site 706587009030 putative aspartate binding site [chemical binding]; other site 706587009031 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 706587009032 putative allosteric regulatory site; other site 706587009033 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 706587009034 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 706587009035 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 706587009036 active site 706587009037 catalytic residues [active] 706587009038 metal binding site [ion binding]; metal-binding site 706587009039 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 706587009040 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 706587009041 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 706587009042 von Willebrand factor type A domain; Region: VWA_2; pfam13519 706587009043 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 706587009044 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 706587009045 catalytic residues [active] 706587009046 Transcription antiterminator [Transcription]; Region: NusG; COG0250 706587009047 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 706587009048 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 706587009049 heterodimer interface [polypeptide binding]; other site 706587009050 homodimer interface [polypeptide binding]; other site 706587009051 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009052 PAS domain; Region: PAS_9; pfam13426 706587009053 putative active site [active] 706587009054 heme pocket [chemical binding]; other site 706587009055 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706587009056 GAF domain; Region: GAF; pfam01590 706587009057 PAS domain S-box; Region: sensory_box; TIGR00229 706587009058 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009059 putative active site [active] 706587009060 heme pocket [chemical binding]; other site 706587009061 PAS fold; Region: PAS_4; pfam08448 706587009062 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009063 putative active site [active] 706587009064 heme pocket [chemical binding]; other site 706587009065 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587009066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587009067 Walker A motif; other site 706587009068 ATP binding site [chemical binding]; other site 706587009069 Walker B motif; other site 706587009070 arginine finger; other site 706587009071 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587009072 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 706587009073 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587009074 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 706587009075 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 706587009076 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587009077 substrate binding site [chemical binding]; other site 706587009078 oxyanion hole (OAH) forming residues; other site 706587009079 trimer interface [polypeptide binding]; other site 706587009080 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 706587009081 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587009082 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587009083 acyl-activating enzyme (AAE) consensus motif; other site 706587009084 AMP binding site [chemical binding]; other site 706587009085 active site 706587009086 CoA binding site [chemical binding]; other site 706587009087 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 706587009088 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587009089 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587009090 Cysteine-rich domain; Region: CCG; pfam02754 706587009091 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 706587009092 CPxP motif; other site 706587009093 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 706587009094 Response regulator receiver domain; Region: Response_reg; pfam00072 706587009095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587009096 active site 706587009097 phosphorylation site [posttranslational modification] 706587009098 intermolecular recognition site; other site 706587009099 dimerization interface [polypeptide binding]; other site 706587009100 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587009101 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 706587009102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009103 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587009104 putative active site [active] 706587009105 heme pocket [chemical binding]; other site 706587009106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009107 putative active site [active] 706587009108 heme pocket [chemical binding]; other site 706587009109 PAS domain S-box; Region: sensory_box; TIGR00229 706587009110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009111 putative active site [active] 706587009112 heme pocket [chemical binding]; other site 706587009113 PAS domain S-box; Region: sensory_box; TIGR00229 706587009114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009115 putative active site [active] 706587009116 heme pocket [chemical binding]; other site 706587009117 PAS domain S-box; Region: sensory_box; TIGR00229 706587009118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009119 putative active site [active] 706587009120 heme pocket [chemical binding]; other site 706587009121 PAS domain S-box; Region: sensory_box; TIGR00229 706587009122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009123 putative active site [active] 706587009124 heme pocket [chemical binding]; other site 706587009125 histidine kinase; Provisional; Region: PRK13557 706587009126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009127 putative active site [active] 706587009128 heme pocket [chemical binding]; other site 706587009129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587009130 dimer interface [polypeptide binding]; other site 706587009131 phosphorylation site [posttranslational modification] 706587009132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587009133 ATP binding site [chemical binding]; other site 706587009134 Mg2+ binding site [ion binding]; other site 706587009135 G-X-G motif; other site 706587009136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587009137 active site 706587009138 phosphorylation site [posttranslational modification] 706587009139 intermolecular recognition site; other site 706587009140 dimerization interface [polypeptide binding]; other site 706587009141 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 706587009142 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 706587009143 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 706587009144 putative NAD(P) binding site [chemical binding]; other site 706587009145 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 706587009146 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 706587009147 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 706587009148 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 706587009149 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587009150 dimerization interface [polypeptide binding]; other site 706587009151 PAS domain S-box; Region: sensory_box; TIGR00229 706587009152 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009153 putative active site [active] 706587009154 heme pocket [chemical binding]; other site 706587009155 PAS domain S-box; Region: sensory_box; TIGR00229 706587009156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009157 putative active site [active] 706587009158 heme pocket [chemical binding]; other site 706587009159 PAS domain S-box; Region: sensory_box; TIGR00229 706587009160 PAS domain; Region: PAS_8; pfam13188 706587009161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009162 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587009163 putative active site [active] 706587009164 heme pocket [chemical binding]; other site 706587009165 PAS domain; Region: PAS; smart00091 706587009166 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587009167 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587009168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009169 putative active site [active] 706587009170 heme pocket [chemical binding]; other site 706587009171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587009172 dimer interface [polypeptide binding]; other site 706587009173 phosphorylation site [posttranslational modification] 706587009174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587009175 ATP binding site [chemical binding]; other site 706587009176 Mg2+ binding site [ion binding]; other site 706587009177 G-X-G motif; other site 706587009178 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587009179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587009180 active site 706587009181 phosphorylation site [posttranslational modification] 706587009182 intermolecular recognition site; other site 706587009183 dimerization interface [polypeptide binding]; other site 706587009184 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 706587009185 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587009186 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 706587009187 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 706587009188 NAD(P) binding site [chemical binding]; other site 706587009189 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 706587009190 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 706587009191 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 706587009192 putative GEF interaction site [polypeptide binding]; other site 706587009193 G1 box; other site 706587009194 GTP/Mg2+ binding site [chemical binding]; other site 706587009195 Switch I region; other site 706587009196 G2 box; other site 706587009197 G3 box; other site 706587009198 Switch II region; other site 706587009199 G4 box; other site 706587009200 G5 box; other site 706587009201 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 706587009202 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 706587009203 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 706587009204 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 706587009205 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 706587009206 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 706587009207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587009208 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 706587009209 Coenzyme A binding pocket [chemical binding]; other site 706587009210 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495 706587009211 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587009212 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 706587009213 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 706587009214 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 706587009215 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 706587009216 active site 706587009217 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 706587009218 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587009219 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 706587009220 ACT domain-containing protein [General function prediction only]; Region: COG4747 706587009221 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 706587009222 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 706587009223 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 706587009224 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 706587009225 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 706587009226 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 706587009227 TPP-binding site [chemical binding]; other site 706587009228 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 706587009229 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 706587009230 dimer interface [polypeptide binding]; other site 706587009231 PYR/PP interface [polypeptide binding]; other site 706587009232 TPP binding site [chemical binding]; other site 706587009233 substrate binding site [chemical binding]; other site 706587009234 Ferredoxin [Energy production and conversion]; Region: COG1146 706587009235 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 706587009236 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587009237 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587009238 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587009239 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587009240 TM-ABC transporter signature motif; other site 706587009241 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587009242 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587009243 TM-ABC transporter signature motif; other site 706587009244 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587009245 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587009246 Walker A/P-loop; other site 706587009247 ATP binding site [chemical binding]; other site 706587009248 Q-loop/lid; other site 706587009249 ABC transporter signature motif; other site 706587009250 Walker B; other site 706587009251 D-loop; other site 706587009252 H-loop/switch region; other site 706587009253 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587009254 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587009255 Walker A/P-loop; other site 706587009256 ATP binding site [chemical binding]; other site 706587009257 Q-loop/lid; other site 706587009258 ABC transporter signature motif; other site 706587009259 Walker B; other site 706587009260 D-loop; other site 706587009261 H-loop/switch region; other site 706587009262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587009263 binding surface 706587009264 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587009265 TPR motif; other site 706587009266 aspartate aminotransferase; Provisional; Region: PRK06836 706587009267 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706587009268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587009269 homodimer interface [polypeptide binding]; other site 706587009270 catalytic residue [active] 706587009271 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 706587009272 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 706587009273 DEAD/DEAH box helicase; Region: DEAD; pfam00270 706587009274 ATP binding site [chemical binding]; other site 706587009275 putative Mg++ binding site [ion binding]; other site 706587009276 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 706587009277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 706587009278 nucleotide binding region [chemical binding]; other site 706587009279 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 706587009280 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 706587009281 homodimer interface [polypeptide binding]; other site 706587009282 substrate-cofactor binding pocket; other site 706587009283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587009284 catalytic residue [active] 706587009285 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 706587009286 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase; Region: dearomat_had; TIGR03201 706587009287 putative NAD(P) binding site [chemical binding]; other site 706587009288 catalytic Zn binding site [ion binding]; other site 706587009289 structural Zn binding site [ion binding]; other site 706587009290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587009291 S-adenosylmethionine binding site [chemical binding]; other site 706587009292 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 706587009293 putative active site [active] 706587009294 catalytic residue [active] 706587009295 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 706587009296 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 706587009297 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587009298 dimerization interface [polypeptide binding]; other site 706587009299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009300 putative active site [active] 706587009301 heme pocket [chemical binding]; other site 706587009302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587009303 dimer interface [polypeptide binding]; other site 706587009304 phosphorylation site [posttranslational modification] 706587009305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587009306 ATP binding site [chemical binding]; other site 706587009307 Mg2+ binding site [ion binding]; other site 706587009308 G-X-G motif; other site 706587009309 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 706587009310 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 706587009311 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587009312 FeS/SAM binding site; other site 706587009313 HemN C-terminal domain; Region: HemN_C; pfam06969 706587009314 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 706587009315 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 706587009316 active site 706587009317 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 706587009318 Uncharacterized conserved protein [Function unknown]; Region: COG3379 706587009319 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 706587009320 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 706587009321 Response regulator receiver domain; Region: Response_reg; pfam00072 706587009322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587009323 active site 706587009324 phosphorylation site [posttranslational modification] 706587009325 intermolecular recognition site; other site 706587009326 dimerization interface [polypeptide binding]; other site 706587009327 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 706587009328 dimer interface [polypeptide binding]; other site 706587009329 catalytic triad [active] 706587009330 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 706587009331 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 706587009332 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 706587009333 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 706587009334 N-acetyl-D-glucosamine binding site [chemical binding]; other site 706587009335 catalytic residue [active] 706587009336 Response regulator receiver domain; Region: Response_reg; pfam00072 706587009337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587009338 active site 706587009339 phosphorylation site [posttranslational modification] 706587009340 intermolecular recognition site; other site 706587009341 dimerization interface [polypeptide binding]; other site 706587009342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587009344 putative active site [active] 706587009345 heme pocket [chemical binding]; other site 706587009346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587009347 dimer interface [polypeptide binding]; other site 706587009348 phosphorylation site [posttranslational modification] 706587009349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587009350 ATP binding site [chemical binding]; other site 706587009351 Mg2+ binding site [ion binding]; other site 706587009352 G-X-G motif; other site 706587009353 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 706587009354 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 706587009355 catalytic center binding site [active] 706587009356 ATP binding site [chemical binding]; other site 706587009357 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 706587009358 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 706587009359 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 706587009360 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 706587009361 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 706587009362 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 706587009363 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 706587009364 dihydrodipicolinate synthase; Region: dapA; TIGR00674 706587009365 dimer interface [polypeptide binding]; other site 706587009366 active site 706587009367 catalytic residue [active] 706587009368 diaminopimelate decarboxylase; Region: lysA; TIGR01048 706587009369 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 706587009370 active site 706587009371 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 706587009372 substrate binding site [chemical binding]; other site 706587009373 catalytic residues [active] 706587009374 dimer interface [polypeptide binding]; other site 706587009375 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 706587009376 Interdomain contacts; other site 706587009377 Cytokine receptor motif; other site 706587009378 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 706587009379 argininosuccinate lyase; Provisional; Region: PRK00855 706587009380 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 706587009381 active sites [active] 706587009382 tetramer interface [polypeptide binding]; other site 706587009383 argininosuccinate synthase; Provisional; Region: PRK13820 706587009384 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 706587009385 ANP binding site [chemical binding]; other site 706587009386 Substrate Binding Site II [chemical binding]; other site 706587009387 Substrate Binding Site I [chemical binding]; other site 706587009388 ornithine carbamoyltransferase; Provisional; Region: PRK00779 706587009389 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 706587009390 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 706587009391 acetylornithine aminotransferase; Provisional; Region: PRK02627 706587009392 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 706587009393 inhibitor-cofactor binding pocket; inhibition site 706587009394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587009395 catalytic residue [active] 706587009396 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 706587009397 feedback inhibition sensing region; other site 706587009398 homohexameric interface [polypeptide binding]; other site 706587009399 nucleotide binding site [chemical binding]; other site 706587009400 N-acetyl-L-glutamate binding site [chemical binding]; other site 706587009401 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 706587009402 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 706587009403 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 706587009404 phosphopeptide binding site; other site 706587009405 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 706587009406 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 706587009407 Protein phosphatase 2C; Region: PP2C; pfam00481 706587009408 active site 706587009409 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 706587009410 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 706587009411 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 706587009412 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 706587009413 protein binding site [polypeptide binding]; other site 706587009414 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 706587009415 putative ligand binding pocket/active site [active] 706587009416 putative metal binding site [ion binding]; other site 706587009417 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 706587009418 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 706587009419 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 706587009420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706587009421 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 706587009422 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706587009423 DNA binding residues [nucleotide binding] 706587009424 DNA primase, catalytic core; Region: dnaG; TIGR01391 706587009425 CHC2 zinc finger; Region: zf-CHC2; pfam01807 706587009426 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 706587009427 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 706587009428 active site 706587009429 metal binding site [ion binding]; metal-binding site 706587009430 interdomain interaction site; other site 706587009431 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 706587009432 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 706587009433 MutS domain III; Region: MutS_III; pfam05192 706587009434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587009435 Walker A/P-loop; other site 706587009436 ATP binding site [chemical binding]; other site 706587009437 Q-loop/lid; other site 706587009438 ABC transporter signature motif; other site 706587009439 Walker B; other site 706587009440 D-loop; other site 706587009441 H-loop/switch region; other site 706587009442 Smr domain; Region: Smr; pfam01713 706587009443 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 706587009444 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 706587009445 substrate binding site [chemical binding]; other site 706587009446 glutamase interaction surface [polypeptide binding]; other site 706587009447 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 706587009448 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 706587009449 catalytic residues [active] 706587009450 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 706587009451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706587009452 NAD(P) binding site [chemical binding]; other site 706587009453 active site 706587009454 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 706587009455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587009456 non-specific DNA binding site [nucleotide binding]; other site 706587009457 salt bridge; other site 706587009458 sequence-specific DNA binding site [nucleotide binding]; other site 706587009459 Cupin domain; Region: Cupin_2; pfam07883 706587009460 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 706587009461 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587009462 active site 706587009463 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 706587009464 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 706587009465 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 706587009466 GSCFA family; Region: GSCFA; pfam08885 706587009467 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 706587009468 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 706587009469 putative active site [active] 706587009470 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 706587009471 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 706587009472 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 706587009473 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 706587009474 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 706587009475 Walker A/P-loop; other site 706587009476 ATP binding site [chemical binding]; other site 706587009477 Q-loop/lid; other site 706587009478 ABC transporter signature motif; other site 706587009479 Walker B; other site 706587009480 D-loop; other site 706587009481 H-loop/switch region; other site 706587009482 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 706587009483 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 706587009484 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 706587009485 active site 706587009486 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 706587009487 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 706587009488 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 706587009489 trimer interface [polypeptide binding]; other site 706587009490 active site 706587009491 UDP-GlcNAc binding site [chemical binding]; other site 706587009492 lipid binding site [chemical binding]; lipid-binding site 706587009493 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 706587009494 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 706587009495 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 706587009496 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 706587009497 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 706587009498 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 706587009499 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 706587009500 Surface antigen; Region: Bac_surface_Ag; pfam01103 706587009501 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 706587009502 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 706587009503 Walker A/P-loop; other site 706587009504 ATP binding site [chemical binding]; other site 706587009505 Q-loop/lid; other site 706587009506 ABC transporter signature motif; other site 706587009507 Walker B; other site 706587009508 D-loop; other site 706587009509 H-loop/switch region; other site 706587009510 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 706587009511 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587009512 FtsX-like permease family; Region: FtsX; pfam02687 706587009513 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 706587009514 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 706587009515 dimer interface [polypeptide binding]; other site 706587009516 putative anticodon binding site; other site 706587009517 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 706587009518 motif 1; other site 706587009519 active site 706587009520 motif 2; other site 706587009521 motif 3; other site 706587009522 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 706587009523 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 706587009524 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 706587009525 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 706587009526 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 706587009527 Walker A motif; other site 706587009528 ATP binding site [chemical binding]; other site 706587009529 Walker B motif; other site 706587009530 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 706587009531 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 706587009532 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 706587009533 Walker A motif; other site 706587009534 ATP binding site [chemical binding]; other site 706587009535 Walker B motif; other site 706587009536 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 706587009537 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 706587009538 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 706587009539 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 706587009540 active site 706587009541 tetramer interface [polypeptide binding]; other site 706587009542 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 706587009543 active site 706587009544 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 706587009545 substrate binding site; other site 706587009546 dimer interface; other site 706587009547 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 706587009548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587009549 active site 706587009550 phosphorylation site [posttranslational modification] 706587009551 intermolecular recognition site; other site 706587009552 dimerization interface [polypeptide binding]; other site 706587009553 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587009554 Zn2+ binding site [ion binding]; other site 706587009555 Mg2+ binding site [ion binding]; other site 706587009556 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 706587009557 N-acetyl-D-glucosamine binding site [chemical binding]; other site 706587009558 catalytic residue [active] 706587009559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587009560 binding surface 706587009561 TPR repeat; Region: TPR_11; pfam13414 706587009562 TPR motif; other site 706587009563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587009564 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587009565 binding surface 706587009566 TPR motif; other site 706587009567 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 706587009568 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 706587009569 substrate binding pocket [chemical binding]; other site 706587009570 chain length determination region; other site 706587009571 substrate-Mg2+ binding site; other site 706587009572 catalytic residues [active] 706587009573 aspartate-rich region 1; other site 706587009574 active site lid residues [active] 706587009575 aspartate-rich region 2; other site 706587009576 TPR repeat; Region: TPR_11; pfam13414 706587009577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587009578 binding surface 706587009579 TPR motif; other site 706587009580 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 706587009581 Domain of unknown function (DUF814); Region: DUF814; pfam05670 706587009582 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 706587009583 trimer interface [polypeptide binding]; other site 706587009584 active site 706587009585 toxin interface [polypeptide binding]; other site 706587009586 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 706587009587 Zn binding site [ion binding]; other site 706587009588 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 706587009589 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 706587009590 catalytic residues [active] 706587009591 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 706587009592 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 706587009593 TPP-binding site [chemical binding]; other site 706587009594 dimer interface [polypeptide binding]; other site 706587009595 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 706587009596 PYR/PP interface [polypeptide binding]; other site 706587009597 dimer interface [polypeptide binding]; other site 706587009598 TPP binding site [chemical binding]; other site 706587009599 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706587009600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587009601 binding surface 706587009602 TPR motif; other site 706587009603 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 706587009604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587009605 binding surface 706587009606 TPR motif; other site 706587009607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587009608 binding surface 706587009609 TPR motif; other site 706587009610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587009611 binding surface 706587009612 TPR motif; other site 706587009613 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 706587009614 FMN binding site [chemical binding]; other site 706587009615 dimer interface [polypeptide binding]; other site 706587009616 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 706587009617 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 706587009618 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 706587009619 active site 706587009620 PHP-associated; Region: PHP_C; pfam13263 706587009621 chaperone protein DnaJ; Provisional; Region: PRK10767 706587009622 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 706587009623 HSP70 interaction site [polypeptide binding]; other site 706587009624 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 706587009625 substrate binding site [polypeptide binding]; other site 706587009626 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 706587009627 Zn binding sites [ion binding]; other site 706587009628 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 706587009629 dimer interface [polypeptide binding]; other site 706587009630 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 706587009631 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 706587009632 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 706587009633 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 706587009634 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 706587009635 putative substrate-binding site; other site 706587009636 nickel binding site [ion binding]; other site 706587009637 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 706587009638 heme-binding residues [chemical binding]; other site 706587009639 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 706587009640 heme-binding residues [chemical binding]; other site 706587009641 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 706587009642 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 706587009643 Response regulator receiver domain; Region: Response_reg; pfam00072 706587009644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587009645 active site 706587009646 phosphorylation site [posttranslational modification] 706587009647 intermolecular recognition site; other site 706587009648 dimerization interface [polypeptide binding]; other site 706587009649 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 706587009650 Na binding site [ion binding]; other site 706587009651 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 706587009652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587009653 dimer interface [polypeptide binding]; other site 706587009654 phosphorylation site [posttranslational modification] 706587009655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587009656 ATP binding site [chemical binding]; other site 706587009657 Mg2+ binding site [ion binding]; other site 706587009658 G-X-G motif; other site 706587009659 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 706587009660 mce related protein; Region: MCE; pfam02470 706587009661 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 706587009662 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 706587009663 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 706587009664 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587009665 acyl-activating enzyme (AAE) consensus motif; other site 706587009666 AMP binding site [chemical binding]; other site 706587009667 active site 706587009668 CoA binding site [chemical binding]; other site 706587009669 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587009670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587009671 Walker A/P-loop; other site 706587009672 ATP binding site [chemical binding]; other site 706587009673 Q-loop/lid; other site 706587009674 ABC transporter signature motif; other site 706587009675 Walker B; other site 706587009676 D-loop; other site 706587009677 H-loop/switch region; other site 706587009678 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587009679 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587009680 Walker A/P-loop; other site 706587009681 ATP binding site [chemical binding]; other site 706587009682 Q-loop/lid; other site 706587009683 ABC transporter signature motif; other site 706587009684 Walker B; other site 706587009685 D-loop; other site 706587009686 H-loop/switch region; other site 706587009687 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587009688 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587009689 TM-ABC transporter signature motif; other site 706587009690 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587009691 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587009692 TM-ABC transporter signature motif; other site 706587009693 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587009694 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587009695 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 706587009696 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 706587009697 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 706587009698 substrate-cofactor binding pocket; other site 706587009699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587009700 catalytic residue [active] 706587009701 MoxR-like ATPases [General function prediction only]; Region: COG0714 706587009702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587009703 Walker A motif; other site 706587009704 ATP binding site [chemical binding]; other site 706587009705 Walker B motif; other site 706587009706 arginine finger; other site 706587009707 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 706587009708 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 706587009709 metal ion-dependent adhesion site (MIDAS); other site 706587009710 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 706587009711 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706587009712 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 706587009713 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 706587009714 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 706587009715 [4Fe-4S] binding site [ion binding]; other site 706587009716 molybdopterin cofactor binding site; other site 706587009717 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 706587009718 molybdopterin cofactor binding site; other site 706587009719 Protein of unknown function (DUF497); Region: DUF497; pfam04365 706587009720 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 706587009721 Protein of unknown function (DUF433); Region: DUF433; pfam04255 706587009722 Bacterial SH3 domain; Region: SH3_3; cl17532 706587009723 PAS domain S-box; Region: sensory_box; TIGR00229 706587009724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009725 putative active site [active] 706587009726 heme pocket [chemical binding]; other site 706587009727 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009728 PAS fold; Region: PAS_3; pfam08447 706587009729 putative active site [active] 706587009730 heme pocket [chemical binding]; other site 706587009731 PAS domain S-box; Region: sensory_box; TIGR00229 706587009732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009733 putative active site [active] 706587009734 heme pocket [chemical binding]; other site 706587009735 PAS domain S-box; Region: sensory_box; TIGR00229 706587009736 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009737 putative active site [active] 706587009738 heme pocket [chemical binding]; other site 706587009739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009740 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587009741 putative active site [active] 706587009742 heme pocket [chemical binding]; other site 706587009743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587009744 dimer interface [polypeptide binding]; other site 706587009745 phosphorylation site [posttranslational modification] 706587009746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587009747 ATP binding site [chemical binding]; other site 706587009748 Mg2+ binding site [ion binding]; other site 706587009749 G-X-G motif; other site 706587009750 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009751 PAS domain; Region: PAS_9; pfam13426 706587009752 putative active site [active] 706587009753 heme pocket [chemical binding]; other site 706587009754 PAS domain S-box; Region: sensory_box; TIGR00229 706587009755 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009756 putative active site [active] 706587009757 heme pocket [chemical binding]; other site 706587009758 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587009759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587009760 dimer interface [polypeptide binding]; other site 706587009761 phosphorylation site [posttranslational modification] 706587009762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587009763 ATP binding site [chemical binding]; other site 706587009764 Mg2+ binding site [ion binding]; other site 706587009765 G-X-G motif; other site 706587009766 Response regulator receiver domain; Region: Response_reg; pfam00072 706587009767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587009768 active site 706587009769 phosphorylation site [posttranslational modification] 706587009770 intermolecular recognition site; other site 706587009771 dimerization interface [polypeptide binding]; other site 706587009772 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587009773 Ankyrin repeat; Region: Ank; pfam00023 706587009774 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587009775 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587009776 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587009777 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587009778 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587009779 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587009780 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587009781 glucokinase, proteobacterial type; Region: glk; TIGR00749 706587009782 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 706587009783 nucleotide binding site [chemical binding]; other site 706587009784 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 706587009785 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 706587009786 Moco binding site; other site 706587009787 metal coordination site [ion binding]; other site 706587009788 mercuric reductase; Validated; Region: PRK06370 706587009789 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587009790 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 706587009791 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 706587009792 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706587009793 GAF domain; Region: GAF; pfam01590 706587009794 YcfA-like protein; Region: YcfA; pfam07927 706587009795 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 706587009796 Phospholipid methyltransferase; Region: PEMT; cl17370 706587009797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587009798 Coenzyme A binding pocket [chemical binding]; other site 706587009799 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 706587009800 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 706587009801 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 706587009802 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 706587009803 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 706587009804 ATP-grasp domain; Region: ATP-grasp_4; cl17255 706587009805 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 706587009806 IMP binding site; other site 706587009807 dimer interface [polypeptide binding]; other site 706587009808 interdomain contacts; other site 706587009809 partial ornithine binding site; other site 706587009810 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 706587009811 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 706587009812 MgtE intracellular N domain; Region: MgtE_N; cl15244 706587009813 PBP superfamily domain; Region: PBP_like_2; cl17296 706587009814 PAS fold; Region: PAS_4; pfam08448 706587009815 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587009816 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009817 putative active site [active] 706587009818 heme pocket [chemical binding]; other site 706587009819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587009820 dimer interface [polypeptide binding]; other site 706587009821 phosphorylation site [posttranslational modification] 706587009822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587009823 ATP binding site [chemical binding]; other site 706587009824 Mg2+ binding site [ion binding]; other site 706587009825 G-X-G motif; other site 706587009826 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 706587009827 protein binding site [polypeptide binding]; other site 706587009828 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 706587009829 Catalytic dyad [active] 706587009830 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 706587009831 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 706587009832 Walker A/P-loop; other site 706587009833 ATP binding site [chemical binding]; other site 706587009834 Q-loop/lid; other site 706587009835 ABC transporter signature motif; other site 706587009836 Walker B; other site 706587009837 D-loop; other site 706587009838 H-loop/switch region; other site 706587009839 purine nucleoside phosphorylase; Provisional; Region: PRK08202 706587009840 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 706587009841 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 706587009842 active site 706587009843 putative substrate binding pocket [chemical binding]; other site 706587009844 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 706587009845 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 706587009846 dimerization interface [polypeptide binding]; other site 706587009847 putative ATP binding site [chemical binding]; other site 706587009848 Protein of unknown function (DUF523); Region: DUF523; pfam04463 706587009849 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 706587009850 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 706587009851 metal binding triad; other site 706587009852 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 706587009853 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 706587009854 metal binding triad; other site 706587009855 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 706587009856 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 706587009857 dimer interface [polypeptide binding]; other site 706587009858 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 706587009859 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 706587009860 B12 binding site [chemical binding]; other site 706587009861 cobalt ligand [ion binding]; other site 706587009862 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 706587009863 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 706587009864 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 706587009865 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 706587009866 Walker A/P-loop; other site 706587009867 ATP binding site [chemical binding]; other site 706587009868 Q-loop/lid; other site 706587009869 ABC transporter signature motif; other site 706587009870 Walker B; other site 706587009871 D-loop; other site 706587009872 H-loop/switch region; other site 706587009873 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 706587009874 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 706587009875 Walker A/P-loop; other site 706587009876 ATP binding site [chemical binding]; other site 706587009877 Q-loop/lid; other site 706587009878 ABC transporter signature motif; other site 706587009879 Walker B; other site 706587009880 D-loop; other site 706587009881 H-loop/switch region; other site 706587009882 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 706587009883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587009884 dimer interface [polypeptide binding]; other site 706587009885 conserved gate region; other site 706587009886 ABC-ATPase subunit interface; other site 706587009887 NMT1/THI5 like; Region: NMT1; pfam09084 706587009888 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706587009889 substrate binding pocket [chemical binding]; other site 706587009890 membrane-bound complex binding site; other site 706587009891 Domain of unknown function DUF39; Region: DUF39; cl14897 706587009892 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587009893 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587009894 Cysteine-rich domain; Region: CCG; pfam02754 706587009895 Cysteine-rich domain; Region: CCG; pfam02754 706587009896 Domain of unknown function DUF39; Region: DUF39; cl14897 706587009897 putative methanogenesis marker 16 metalloprotein; Region: methan_mark_16; TIGR03287 706587009898 Domain of unknown function DUF39; Region: DUF39; cl14897 706587009899 hypothetical protein; Provisional; Region: PRK04334 706587009900 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 706587009901 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 706587009902 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 706587009903 molybdopterin cofactor binding site; other site 706587009904 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 706587009905 PAS fold; Region: PAS; pfam00989 706587009906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009907 putative active site [active] 706587009908 heme pocket [chemical binding]; other site 706587009909 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587009910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587009911 Walker A motif; other site 706587009912 ATP binding site [chemical binding]; other site 706587009913 Walker B motif; other site 706587009914 arginine finger; other site 706587009915 O-Antigen ligase; Region: Wzy_C; cl04850 706587009916 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587009917 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 706587009918 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 706587009919 PYR/PP interface [polypeptide binding]; other site 706587009920 dimer interface [polypeptide binding]; other site 706587009921 TPP binding site [chemical binding]; other site 706587009922 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 706587009923 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 706587009924 TPP-binding site [chemical binding]; other site 706587009925 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 706587009926 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587009927 non-specific DNA binding site [nucleotide binding]; other site 706587009928 salt bridge; other site 706587009929 sequence-specific DNA binding site [nucleotide binding]; other site 706587009930 Cupin domain; Region: Cupin_2; pfam07883 706587009931 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587009932 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587009933 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 706587009934 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 706587009935 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 706587009936 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587009937 PAS domain; Region: PAS_8; pfam13188 706587009938 PAS fold; Region: PAS_4; pfam08448 706587009939 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587009940 putative active site [active] 706587009941 heme pocket [chemical binding]; other site 706587009942 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587009943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587009944 Walker A motif; other site 706587009945 ATP binding site [chemical binding]; other site 706587009946 Walker B motif; other site 706587009947 arginine finger; other site 706587009948 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587009949 PRC-barrel domain; Region: PRC; pfam05239 706587009950 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 706587009951 Flavoprotein; Region: Flavoprotein; pfam02441 706587009952 DctM-like transporters; Region: DctM; pfam06808 706587009953 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 706587009954 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 706587009955 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 706587009956 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 706587009957 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 706587009958 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 706587009959 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 706587009960 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 706587009961 hypothetical protein; Validated; Region: PRK06201 706587009962 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 706587009963 L-aspartate oxidase; Provisional; Region: PRK06175 706587009964 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 706587009965 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 706587009966 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 706587009967 phosphate binding site [ion binding]; other site 706587009968 4Fe-4S binding domain; Region: Fer4; pfam00037 706587009969 4Fe-4S binding domain; Region: Fer4_6; pfam12837 706587009970 Transcriptional regulators [Transcription]; Region: FadR; COG2186 706587009971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706587009972 DNA-binding site [nucleotide binding]; DNA binding site 706587009973 FCD domain; Region: FCD; pfam07729 706587009974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587009975 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587009976 Isochorismatase family; Region: Isochorismatase; pfam00857 706587009977 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 706587009978 catalytic triad [active] 706587009979 metal binding site [ion binding]; metal-binding site 706587009980 conserved cis-peptide bond; other site 706587009981 acyl-CoA synthetase; Validated; Region: PRK08316 706587009982 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587009983 acyl-activating enzyme (AAE) consensus motif; other site 706587009984 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 706587009985 acyl-activating enzyme (AAE) consensus motif; other site 706587009986 putative AMP binding site [chemical binding]; other site 706587009987 putative active site [active] 706587009988 putative CoA binding site [chemical binding]; other site 706587009989 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 706587009990 putative active site [active] 706587009991 putative catalytic site [active] 706587009992 Domain of unknown function (DUF955); Region: DUF955; pfam06114 706587009993 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 706587009994 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 706587009995 dimer interface [polypeptide binding]; other site 706587009996 acyl-activating enzyme (AAE) consensus motif; other site 706587009997 putative active site [active] 706587009998 AMP binding site [chemical binding]; other site 706587009999 putative CoA binding site [chemical binding]; other site 706587010000 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587010001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010002 active site 706587010003 phosphorylation site [posttranslational modification] 706587010004 intermolecular recognition site; other site 706587010005 dimerization interface [polypeptide binding]; other site 706587010006 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010007 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587010008 putative active site [active] 706587010009 heme pocket [chemical binding]; other site 706587010010 PAS domain S-box; Region: sensory_box; TIGR00229 706587010011 histidine kinase; Provisional; Region: PRK13557 706587010012 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010013 putative active site [active] 706587010014 heme pocket [chemical binding]; other site 706587010015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587010016 dimer interface [polypeptide binding]; other site 706587010017 phosphorylation site [posttranslational modification] 706587010018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587010019 ATP binding site [chemical binding]; other site 706587010020 Mg2+ binding site [ion binding]; other site 706587010021 G-X-G motif; other site 706587010022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010023 active site 706587010024 phosphorylation site [posttranslational modification] 706587010025 intermolecular recognition site; other site 706587010026 dimerization interface [polypeptide binding]; other site 706587010027 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 706587010028 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 706587010029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587010030 Walker A motif; other site 706587010031 ATP binding site [chemical binding]; other site 706587010032 Walker B motif; other site 706587010033 arginine finger; other site 706587010034 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587010035 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 706587010036 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 706587010037 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 706587010038 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 706587010039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 706587010040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 706587010041 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14611 706587010042 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 706587010043 Putative methyltransferase; Region: Methyltransf_16; pfam10294 706587010044 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010045 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587010046 putative active site [active] 706587010047 heme pocket [chemical binding]; other site 706587010048 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587010049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010050 putative active site [active] 706587010051 heme pocket [chemical binding]; other site 706587010052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010053 putative active site [active] 706587010054 heme pocket [chemical binding]; other site 706587010055 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587010056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010057 putative active site [active] 706587010058 heme pocket [chemical binding]; other site 706587010059 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706587010060 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010061 PAS fold; Region: PAS_3; pfam08447 706587010062 putative active site [active] 706587010063 heme pocket [chemical binding]; other site 706587010064 histidine kinase; Provisional; Region: PRK13557 706587010065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010066 putative active site [active] 706587010067 heme pocket [chemical binding]; other site 706587010068 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587010069 dimer interface [polypeptide binding]; other site 706587010070 phosphorylation site [posttranslational modification] 706587010071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587010072 ATP binding site [chemical binding]; other site 706587010073 Mg2+ binding site [ion binding]; other site 706587010074 G-X-G motif; other site 706587010075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010076 active site 706587010077 phosphorylation site [posttranslational modification] 706587010078 intermolecular recognition site; other site 706587010079 dimerization interface [polypeptide binding]; other site 706587010080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010081 PAS domain; Region: PAS_9; pfam13426 706587010082 putative active site [active] 706587010083 heme pocket [chemical binding]; other site 706587010084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010085 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587010086 putative active site [active] 706587010087 heme pocket [chemical binding]; other site 706587010088 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587010089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010090 putative active site [active] 706587010091 heme pocket [chemical binding]; other site 706587010092 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010093 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587010094 putative active site [active] 706587010095 heme pocket [chemical binding]; other site 706587010096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587010097 dimer interface [polypeptide binding]; other site 706587010098 phosphorylation site [posttranslational modification] 706587010099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587010100 ATP binding site [chemical binding]; other site 706587010101 Mg2+ binding site [ion binding]; other site 706587010102 G-X-G motif; other site 706587010103 Response regulator receiver domain; Region: Response_reg; pfam00072 706587010104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010105 active site 706587010106 phosphorylation site [posttranslational modification] 706587010107 intermolecular recognition site; other site 706587010108 dimerization interface [polypeptide binding]; other site 706587010109 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 706587010110 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 706587010111 Cl binding site [ion binding]; other site 706587010112 oligomer interface [polypeptide binding]; other site 706587010113 Protein of unknown function, DUF488; Region: DUF488; cl01246 706587010114 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 706587010115 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 706587010116 molybdopterin cofactor binding site; other site 706587010117 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 706587010118 molybdopterin cofactor binding site; other site 706587010119 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 706587010120 MarR family; Region: MarR_2; pfam12802 706587010121 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 706587010122 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 706587010123 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 706587010124 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 706587010125 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 706587010126 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 706587010127 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 706587010128 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 706587010129 DsbD alpha interface [polypeptide binding]; other site 706587010130 catalytic residues [active] 706587010131 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 706587010132 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 706587010133 conserved cys residue [active] 706587010134 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 706587010135 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 706587010136 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 706587010137 dimer interface [polypeptide binding]; other site 706587010138 PYR/PP interface [polypeptide binding]; other site 706587010139 TPP binding site [chemical binding]; other site 706587010140 substrate binding site [chemical binding]; other site 706587010141 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 706587010142 TPP-binding site; other site 706587010143 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 706587010144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 706587010145 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 706587010146 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 706587010147 dimerization interface [polypeptide binding]; other site 706587010148 putative ATP binding site [chemical binding]; other site 706587010149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706587010150 NAD(P) binding site [chemical binding]; other site 706587010151 active site 706587010152 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 706587010153 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 706587010154 phosphate binding site [ion binding]; other site 706587010155 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 706587010156 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 706587010157 active site 706587010158 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 706587010159 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 706587010160 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 706587010161 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 706587010162 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 706587010163 putative NADP binding site [chemical binding]; other site 706587010164 active site 706587010165 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 706587010166 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 706587010167 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 706587010168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587010169 Radical SAM superfamily; Region: Radical_SAM; pfam04055 706587010170 FeS/SAM binding site; other site 706587010171 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 706587010172 IHF dimer interface [polypeptide binding]; other site 706587010173 IHF - DNA interface [nucleotide binding]; other site 706587010174 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 706587010175 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 706587010176 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 706587010177 S-adenosylmethionine synthetase; Validated; Region: PRK05250 706587010178 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 706587010179 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 706587010180 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 706587010181 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 706587010182 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 706587010183 homotetramer interface [polypeptide binding]; other site 706587010184 ligand binding site [chemical binding]; other site 706587010185 catalytic site [active] 706587010186 NAD binding site [chemical binding]; other site 706587010187 Response regulator receiver domain; Region: Response_reg; pfam00072 706587010188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010189 active site 706587010190 phosphorylation site [posttranslational modification] 706587010191 intermolecular recognition site; other site 706587010192 dimerization interface [polypeptide binding]; other site 706587010193 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706587010194 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706587010195 metal binding site [ion binding]; metal-binding site 706587010196 active site 706587010197 I-site; other site 706587010198 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 706587010199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587010200 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 706587010201 Walker A motif; other site 706587010202 ATP binding site [chemical binding]; other site 706587010203 Walker B motif; other site 706587010204 arginine finger; other site 706587010205 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 706587010206 active site 706587010207 catalytic residues [active] 706587010208 metal binding site [ion binding]; metal-binding site 706587010209 large terminase protein; Provisional; Region: 17; PHA02533 706587010210 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 706587010211 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 706587010212 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 706587010213 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 706587010214 Galactose oxidase, central domain; Region: Kelch_3; cl02701 706587010215 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 706587010216 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 706587010217 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 706587010218 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 706587010219 DXD motif; other site 706587010220 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 706587010221 putative acyl-acceptor binding pocket; other site 706587010222 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 706587010223 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 706587010224 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 706587010225 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 706587010226 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 706587010227 generic binding surface I; other site 706587010228 generic binding surface II; other site 706587010229 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587010230 Zn2+ binding site [ion binding]; other site 706587010231 Mg2+ binding site [ion binding]; other site 706587010232 hypothetical protein; Provisional; Region: PRK07338 706587010233 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 706587010234 metal binding site [ion binding]; metal-binding site 706587010235 dimer interface [polypeptide binding]; other site 706587010236 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010237 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 706587010238 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587010239 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010240 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587010241 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010242 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587010243 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010244 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587010245 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010246 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587010247 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010248 PRC-barrel domain; Region: PRC; pfam05239 706587010249 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 706587010250 B12 binding site [chemical binding]; other site 706587010251 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 706587010252 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 706587010253 FeS/SAM binding site; other site 706587010254 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 706587010255 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 706587010256 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587010257 4Fe-4S binding domain; Region: Fer4_6; pfam12837 706587010258 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 706587010259 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 706587010260 active site 706587010261 metal binding site [ion binding]; metal-binding site 706587010262 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 706587010263 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 706587010264 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 706587010265 P loop; other site 706587010266 GTP binding site [chemical binding]; other site 706587010267 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 706587010268 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 706587010269 RNA/DNA hybrid binding site [nucleotide binding]; other site 706587010270 active site 706587010271 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 706587010272 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 706587010273 GDP-binding site [chemical binding]; other site 706587010274 ACT binding site; other site 706587010275 IMP binding site; other site 706587010276 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 706587010277 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 706587010278 ligand binding site [chemical binding]; other site 706587010279 NAD binding site [chemical binding]; other site 706587010280 dimerization interface [polypeptide binding]; other site 706587010281 catalytic site [active] 706587010282 ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879 706587010283 L-serine binding site [chemical binding]; other site 706587010284 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 706587010285 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706587010286 catalytic residue [active] 706587010287 Haemolysin-III related; Region: HlyIII; cl03831 706587010288 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 706587010289 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 706587010290 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706587010291 N-terminal plug; other site 706587010292 ligand-binding site [chemical binding]; other site 706587010293 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 706587010294 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 706587010295 homodimer interface [polypeptide binding]; other site 706587010296 Walker A motif; other site 706587010297 ATP binding site [chemical binding]; other site 706587010298 hydroxycobalamin binding site [chemical binding]; other site 706587010299 Walker B motif; other site 706587010300 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 706587010301 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 706587010302 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 706587010303 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 706587010304 intersubunit interface [polypeptide binding]; other site 706587010305 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 706587010306 Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919 706587010307 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 706587010308 Predicted transporter (DUF2162); Region: DUF2162; cl01990 706587010309 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 706587010310 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 706587010311 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 706587010312 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 706587010313 active site 706587010314 catalytic residues [active] 706587010315 DNA binding site [nucleotide binding] 706587010316 Int/Topo IB signature motif; other site 706587010317 Helix-turn-helix domain; Region: HTH_17; pfam12728 706587010318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587010319 non-specific DNA binding site [nucleotide binding]; other site 706587010320 salt bridge; other site 706587010321 sequence-specific DNA binding site [nucleotide binding]; other site 706587010322 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 706587010323 polymerase nucleotide-binding site; other site 706587010324 DNA-binding residues [nucleotide binding]; DNA binding site 706587010325 nucleotide binding site [chemical binding]; other site 706587010326 primase nucleotide-binding site [nucleotide binding]; other site 706587010327 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 706587010328 D5 N terminal like; Region: D5_N; pfam08706 706587010329 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 706587010330 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 706587010331 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 706587010332 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 706587010333 catalytic residues [active] 706587010334 catalytic nucleophile [active] 706587010335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 706587010336 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 706587010337 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 706587010338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587010339 non-specific DNA binding site [nucleotide binding]; other site 706587010340 salt bridge; other site 706587010341 sequence-specific DNA binding site [nucleotide binding]; other site 706587010342 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 706587010343 active site 706587010344 catalytic residues [active] 706587010345 DNA binding site [nucleotide binding] 706587010346 Int/Topo IB signature motif; other site 706587010347 Helix-turn-helix domain; Region: HTH_17; pfam12728 706587010348 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587010349 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010350 PAS fold; Region: PAS_4; pfam08448 706587010351 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587010352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587010353 Walker A motif; other site 706587010354 ATP binding site [chemical binding]; other site 706587010355 Walker B motif; other site 706587010356 arginine finger; other site 706587010357 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587010358 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 706587010359 Double zinc ribbon; Region: DZR; pfam12773 706587010360 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 706587010361 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706587010362 DNA binding residues [nucleotide binding] 706587010363 Putative zinc-finger; Region: zf-HC2; pfam13490 706587010364 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 706587010365 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 706587010366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587010367 S-adenosylmethionine binding site [chemical binding]; other site 706587010368 DEAD-like helicases superfamily; Region: DEXDc; smart00487 706587010369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706587010370 nucleotide binding region [chemical binding]; other site 706587010371 ATP-binding site [chemical binding]; other site 706587010372 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 706587010373 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 706587010374 cyclase homology domain; Region: CHD; cd07302 706587010375 nucleotidyl binding site; other site 706587010376 metal binding site [ion binding]; metal-binding site 706587010377 dimer interface [polypeptide binding]; other site 706587010378 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 706587010379 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706587010380 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 706587010381 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 706587010382 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 706587010383 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 706587010384 putative dimer interface [polypeptide binding]; other site 706587010385 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 706587010386 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 706587010387 putative dimer interface [polypeptide binding]; other site 706587010388 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 706587010389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587010390 FeS/SAM binding site; other site 706587010391 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 706587010392 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 706587010393 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587010394 putative ADP-binding pocket [chemical binding]; other site 706587010395 Cupin domain; Region: Cupin_2; cl17218 706587010396 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 706587010397 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 706587010398 Substrate binding site; other site 706587010399 Cupin domain; Region: Cupin_2; cl17218 706587010400 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587010401 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 706587010402 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 706587010403 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706587010404 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587010405 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 706587010406 Domain of unknown function (DUF377); Region: DUF377; pfam04041 706587010407 active site 706587010408 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 706587010409 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 706587010410 active site 706587010411 DNA binding site [nucleotide binding] 706587010412 Int/Topo IB signature motif; other site 706587010413 Helix-turn-helix domain; Region: HTH_17; pfam12728 706587010414 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 706587010415 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 706587010416 DNA binding residues [nucleotide binding] 706587010417 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 706587010418 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 706587010419 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 706587010420 Predicted helicase [General function prediction only]; Region: COG4889 706587010421 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587010422 HNH endonuclease; Region: HNH_5; pfam14279 706587010423 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 706587010424 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 706587010425 active site 706587010426 DNA binding site [nucleotide binding] 706587010427 Int/Topo IB signature motif; other site 706587010428 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 706587010429 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 706587010430 DNA methylase; Region: N6_N4_Mtase; pfam01555 706587010431 Methyltransferase domain; Region: Methyltransf_26; pfam13659 706587010432 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 706587010433 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 706587010434 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 706587010435 active site 706587010436 NTP binding site [chemical binding]; other site 706587010437 metal binding triad [ion binding]; metal-binding site 706587010438 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 706587010439 active site 706587010440 NTP binding site [chemical binding]; other site 706587010441 metal binding triad [ion binding]; metal-binding site 706587010442 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 706587010443 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 706587010444 active site 706587010445 Int/Topo IB signature motif; other site 706587010446 catalytic residues [active] 706587010447 DNA binding site [nucleotide binding] 706587010448 Helix-turn-helix domain; Region: HTH_17; pfam12728 706587010449 CHC2 zinc finger; Region: zf-CHC2; cl17510 706587010450 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 706587010451 active site 706587010452 metal binding site [ion binding]; metal-binding site 706587010453 interdomain interaction site; other site 706587010454 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 706587010455 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 706587010456 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 706587010457 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587010458 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010459 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587010460 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010461 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587010462 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010463 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587010464 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010465 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 706587010466 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 706587010467 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 706587010468 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010469 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587010470 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010471 Ankyrin repeat; Region: Ank; pfam00023 706587010472 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010473 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587010474 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010475 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587010476 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587010477 Peptidase family M23; Region: Peptidase_M23; pfam01551 706587010478 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 706587010479 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 706587010480 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 706587010481 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 706587010482 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 706587010483 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 706587010484 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 706587010485 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 706587010486 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 706587010487 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 706587010488 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 706587010489 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 706587010490 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 706587010491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587010492 Walker A/P-loop; other site 706587010493 ATP binding site [chemical binding]; other site 706587010494 Q-loop/lid; other site 706587010495 ABC transporter signature motif; other site 706587010496 Walker B; other site 706587010497 D-loop; other site 706587010498 H-loop/switch region; other site 706587010499 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 706587010500 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587010501 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587010502 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 706587010503 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 706587010504 L-aspartate oxidase; Provisional; Region: PRK06175 706587010505 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 706587010506 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 706587010507 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 706587010508 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 706587010509 homotrimer interaction site [polypeptide binding]; other site 706587010510 putative active site [active] 706587010511 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 706587010512 amidohydrolase; Region: amidohydrolases; TIGR01891 706587010513 putative metal binding site [ion binding]; other site 706587010514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587010515 D-galactonate transporter; Region: 2A0114; TIGR00893 706587010516 putative substrate translocation pore; other site 706587010517 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 706587010518 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 706587010519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 706587010520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587010521 Walker A motif; other site 706587010522 ATP binding site [chemical binding]; other site 706587010523 Walker B motif; other site 706587010524 arginine finger; other site 706587010525 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 706587010526 LysE type translocator; Region: LysE; cl00565 706587010527 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 706587010528 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 706587010529 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706587010530 membrane-bound complex binding site; other site 706587010531 hinge residues; other site 706587010532 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587010533 dimerization interface [polypeptide binding]; other site 706587010534 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587010535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010536 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587010537 putative active site [active] 706587010538 heme pocket [chemical binding]; other site 706587010539 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587010540 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010541 putative active site [active] 706587010542 heme pocket [chemical binding]; other site 706587010543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587010544 dimer interface [polypeptide binding]; other site 706587010545 phosphorylation site [posttranslational modification] 706587010546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587010547 ATP binding site [chemical binding]; other site 706587010548 Mg2+ binding site [ion binding]; other site 706587010549 G-X-G motif; other site 706587010550 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587010551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010552 active site 706587010553 phosphorylation site [posttranslational modification] 706587010554 intermolecular recognition site; other site 706587010555 dimerization interface [polypeptide binding]; other site 706587010556 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587010557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010558 active site 706587010559 phosphorylation site [posttranslational modification] 706587010560 intermolecular recognition site; other site 706587010561 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010562 putative active site [active] 706587010563 PAS fold; Region: PAS_3; pfam08447 706587010564 heme pocket [chemical binding]; other site 706587010565 PAS fold; Region: PAS_4; pfam08448 706587010566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010567 putative active site [active] 706587010568 heme pocket [chemical binding]; other site 706587010569 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587010570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587010571 Walker A motif; other site 706587010572 ATP binding site [chemical binding]; other site 706587010573 Walker B motif; other site 706587010574 arginine finger; other site 706587010575 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 706587010576 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 706587010577 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587010578 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 706587010579 dimerization interface [polypeptide binding]; other site 706587010580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587010581 dimer interface [polypeptide binding]; other site 706587010582 phosphorylation site [posttranslational modification] 706587010583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587010584 ATP binding site [chemical binding]; other site 706587010585 Mg2+ binding site [ion binding]; other site 706587010586 G-X-G motif; other site 706587010587 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010588 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587010589 putative active site [active] 706587010590 heme pocket [chemical binding]; other site 706587010591 PAS domain; Region: PAS_8; pfam13188 706587010592 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587010593 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587010595 putative active site [active] 706587010596 heme pocket [chemical binding]; other site 706587010597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587010598 dimer interface [polypeptide binding]; other site 706587010599 phosphorylation site [posttranslational modification] 706587010600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587010601 ATP binding site [chemical binding]; other site 706587010602 Mg2+ binding site [ion binding]; other site 706587010603 G-X-G motif; other site 706587010604 Response regulator receiver domain; Region: Response_reg; pfam00072 706587010605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010606 active site 706587010607 phosphorylation site [posttranslational modification] 706587010608 intermolecular recognition site; other site 706587010609 dimerization interface [polypeptide binding]; other site 706587010610 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 706587010611 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 706587010612 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 706587010613 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587010614 hypothetical protein; Validated; Region: PRK09039 706587010615 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 706587010616 ligand binding site [chemical binding]; other site 706587010617 TIGR03943 family protein; Region: TIGR03943 706587010618 Predicted permeases [General function prediction only]; Region: COG0701 706587010619 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 706587010620 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706587010621 ABC-ATPase subunit interface; other site 706587010622 dimer interface [polypeptide binding]; other site 706587010623 putative PBP binding regions; other site 706587010624 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 706587010625 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 706587010626 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 706587010627 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 706587010628 putative metal binding residues [ion binding]; other site 706587010629 hypothetical protein; Region: PHA01748 706587010630 ADP-glucose phosphorylase; Region: PLN02643 706587010631 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 706587010632 nucleotide binding site/active site [active] 706587010633 HIT family signature motif; other site 706587010634 catalytic residue [active] 706587010635 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 706587010636 SnoaL-like domain; Region: SnoaL_3; pfam13474 706587010637 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 706587010638 active site 706587010639 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706587010640 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 706587010641 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587010642 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587010643 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587010644 dimerization interface [polypeptide binding]; other site 706587010645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587010646 dimer interface [polypeptide binding]; other site 706587010647 phosphorylation site [posttranslational modification] 706587010648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587010649 ATP binding site [chemical binding]; other site 706587010650 Mg2+ binding site [ion binding]; other site 706587010651 G-X-G motif; other site 706587010652 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 706587010653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010654 active site 706587010655 phosphorylation site [posttranslational modification] 706587010656 intermolecular recognition site; other site 706587010657 dimerization interface [polypeptide binding]; other site 706587010658 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706587010659 DNA binding site [nucleotide binding] 706587010660 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 706587010661 dimer interface [polypeptide binding]; other site 706587010662 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 706587010663 macrolide transporter subunit MacA; Provisional; Region: PRK11578 706587010664 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 706587010665 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587010666 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587010667 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 706587010668 FtsX-like permease family; Region: FtsX; pfam02687 706587010669 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587010670 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 706587010671 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 706587010672 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 706587010673 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706587010674 intracellular protease, PfpI family; Region: PfpI; TIGR01382 706587010675 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 706587010676 conserved cys residue [active] 706587010677 PBP superfamily domain; Region: PBP_like_2; cl17296 706587010678 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 706587010679 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 706587010680 Walker A/P-loop; other site 706587010681 ATP binding site [chemical binding]; other site 706587010682 Q-loop/lid; other site 706587010683 ABC transporter signature motif; other site 706587010684 Walker B; other site 706587010685 D-loop; other site 706587010686 H-loop/switch region; other site 706587010687 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 706587010688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587010689 dimer interface [polypeptide binding]; other site 706587010690 conserved gate region; other site 706587010691 putative PBP binding loops; other site 706587010692 ABC-ATPase subunit interface; other site 706587010693 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 706587010694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587010695 dimer interface [polypeptide binding]; other site 706587010696 conserved gate region; other site 706587010697 putative PBP binding loops; other site 706587010698 ABC-ATPase subunit interface; other site 706587010699 PBP superfamily domain; Region: PBP_like_2; cl17296 706587010700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587010701 S-adenosylmethionine binding site [chemical binding]; other site 706587010702 PAS domain; Region: PAS; smart00091 706587010703 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587010704 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587010705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010706 putative active site [active] 706587010707 heme pocket [chemical binding]; other site 706587010708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 706587010709 Histidine kinase; Region: HisKA_2; pfam07568 706587010710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587010711 ATP binding site [chemical binding]; other site 706587010712 Mg2+ binding site [ion binding]; other site 706587010713 G-X-G motif; other site 706587010714 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 706587010715 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 706587010716 dimerization interface [polypeptide binding]; other site 706587010717 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 706587010718 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 706587010719 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 706587010720 Response regulator receiver domain; Region: Response_reg; pfam00072 706587010721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010722 active site 706587010723 phosphorylation site [posttranslational modification] 706587010724 intermolecular recognition site; other site 706587010725 dimerization interface [polypeptide binding]; other site 706587010726 PAS fold; Region: PAS_4; pfam08448 706587010727 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010728 putative active site [active] 706587010729 heme pocket [chemical binding]; other site 706587010730 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587010731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587010732 Walker A motif; other site 706587010733 ATP binding site [chemical binding]; other site 706587010734 Walker B motif; other site 706587010735 arginine finger; other site 706587010736 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587010737 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587010738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010739 active site 706587010740 phosphorylation site [posttranslational modification] 706587010741 intermolecular recognition site; other site 706587010742 dimerization interface [polypeptide binding]; other site 706587010743 PAS domain; Region: PAS_8; pfam13188 706587010744 PAS domain; Region: PAS_9; pfam13426 706587010745 PAS domain; Region: PAS_9; pfam13426 706587010746 PAS domain; Region: PAS_9; pfam13426 706587010747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010748 putative active site [active] 706587010749 heme pocket [chemical binding]; other site 706587010750 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587010751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587010752 dimer interface [polypeptide binding]; other site 706587010753 phosphorylation site [posttranslational modification] 706587010754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587010755 ATP binding site [chemical binding]; other site 706587010756 Mg2+ binding site [ion binding]; other site 706587010757 G-X-G motif; other site 706587010758 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587010759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010760 active site 706587010761 phosphorylation site [posttranslational modification] 706587010762 intermolecular recognition site; other site 706587010763 dimerization interface [polypeptide binding]; other site 706587010764 PAS domain S-box; Region: sensory_box; TIGR00229 706587010765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010766 putative active site [active] 706587010767 heme pocket [chemical binding]; other site 706587010768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 706587010769 Histidine kinase; Region: HisKA_2; pfam07568 706587010770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587010771 ATP binding site [chemical binding]; other site 706587010772 Mg2+ binding site [ion binding]; other site 706587010773 G-X-G motif; other site 706587010774 Hemerythrin; Region: Hemerythrin; cd12107 706587010775 Fe binding site [ion binding]; other site 706587010776 PilZ domain; Region: PilZ; pfam07238 706587010777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587010778 dimer interface [polypeptide binding]; other site 706587010779 phosphorylation site [posttranslational modification] 706587010780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587010781 ATP binding site [chemical binding]; other site 706587010782 Mg2+ binding site [ion binding]; other site 706587010783 G-X-G motif; other site 706587010784 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587010785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010786 active site 706587010787 phosphorylation site [posttranslational modification] 706587010788 intermolecular recognition site; other site 706587010789 dimerization interface [polypeptide binding]; other site 706587010790 Uncharacterized conserved protein [Function unknown]; Region: COG5361 706587010791 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 706587010792 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 706587010793 Response regulator receiver domain; Region: Response_reg; pfam00072 706587010794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010795 active site 706587010796 phosphorylation site [posttranslational modification] 706587010797 intermolecular recognition site; other site 706587010798 dimerization interface [polypeptide binding]; other site 706587010799 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 706587010800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010801 active site 706587010802 Response regulator receiver domain; Region: Response_reg; pfam00072 706587010803 phosphorylation site [posttranslational modification] 706587010804 intermolecular recognition site; other site 706587010805 dimerization interface [polypeptide binding]; other site 706587010806 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010807 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587010808 putative active site [active] 706587010809 heme pocket [chemical binding]; other site 706587010810 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010811 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587010812 putative active site [active] 706587010813 heme pocket [chemical binding]; other site 706587010814 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587010815 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587010816 putative active site [active] 706587010817 heme pocket [chemical binding]; other site 706587010818 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587010819 dimer interface [polypeptide binding]; other site 706587010820 phosphorylation site [posttranslational modification] 706587010821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587010822 ATP binding site [chemical binding]; other site 706587010823 Mg2+ binding site [ion binding]; other site 706587010824 G-X-G motif; other site 706587010825 Response regulator receiver domain; Region: Response_reg; pfam00072 706587010826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010827 active site 706587010828 phosphorylation site [posttranslational modification] 706587010829 intermolecular recognition site; other site 706587010830 dimerization interface [polypeptide binding]; other site 706587010831 Response regulator receiver domain; Region: Response_reg; pfam00072 706587010832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010833 active site 706587010834 phosphorylation site [posttranslational modification] 706587010835 intermolecular recognition site; other site 706587010836 dimerization interface [polypeptide binding]; other site 706587010837 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 706587010838 MOSC domain; Region: MOSC; pfam03473 706587010839 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 706587010840 elongation factor G; Reviewed; Region: PRK12740 706587010841 G1 box; other site 706587010842 putative GEF interaction site [polypeptide binding]; other site 706587010843 GTP/Mg2+ binding site [chemical binding]; other site 706587010844 Switch I region; other site 706587010845 G2 box; other site 706587010846 G3 box; other site 706587010847 Switch II region; other site 706587010848 G4 box; other site 706587010849 G5 box; other site 706587010850 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 706587010851 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 706587010852 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 706587010853 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587010854 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587010855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587010856 non-specific DNA binding site [nucleotide binding]; other site 706587010857 salt bridge; other site 706587010858 sequence-specific DNA binding site [nucleotide binding]; other site 706587010859 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 706587010860 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 706587010861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706587010862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587010863 homodimer interface [polypeptide binding]; other site 706587010864 catalytic residue [active] 706587010865 cytidylate kinase; Provisional; Region: cmk; PRK00023 706587010866 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 706587010867 CMP-binding site; other site 706587010868 The sites determining sugar specificity; other site 706587010869 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 706587010870 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 706587010871 RNA binding site [nucleotide binding]; other site 706587010872 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 706587010873 RNA binding site [nucleotide binding]; other site 706587010874 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 706587010875 RNA binding site [nucleotide binding]; other site 706587010876 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 706587010877 RNA binding site [nucleotide binding]; other site 706587010878 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 706587010879 RNA binding site [nucleotide binding]; other site 706587010880 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 706587010881 RNA binding site [nucleotide binding]; other site 706587010882 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 706587010883 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 706587010884 active site 706587010885 NTP binding site [chemical binding]; other site 706587010886 metal binding triad [ion binding]; metal-binding site 706587010887 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 706587010888 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587010889 Zn2+ binding site [ion binding]; other site 706587010890 Mg2+ binding site [ion binding]; other site 706587010891 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 706587010892 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 706587010893 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 706587010894 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 706587010895 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587010896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587010897 active site 706587010898 phosphorylation site [posttranslational modification] 706587010899 intermolecular recognition site; other site 706587010900 dimerization interface [polypeptide binding]; other site 706587010901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587010902 Walker A motif; other site 706587010903 ATP binding site [chemical binding]; other site 706587010904 Walker B motif; other site 706587010905 arginine finger; other site 706587010906 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587010907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587010908 dimer interface [polypeptide binding]; other site 706587010909 phosphorylation site [posttranslational modification] 706587010910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587010911 ATP binding site [chemical binding]; other site 706587010912 Mg2+ binding site [ion binding]; other site 706587010913 G-X-G motif; other site 706587010914 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 706587010915 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 706587010916 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587010917 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 706587010918 Protein of unknown function (DUF721); Region: DUF721; pfam05258 706587010919 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 706587010920 MPT binding site; other site 706587010921 trimer interface [polypeptide binding]; other site 706587010922 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 706587010923 Protease prsW family; Region: PrsW-protease; pfam13367 706587010924 Double zinc ribbon; Region: DZR; pfam12773 706587010925 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 706587010926 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706587010927 Walker A/P-loop; other site 706587010928 ATP binding site [chemical binding]; other site 706587010929 Q-loop/lid; other site 706587010930 ABC transporter signature motif; other site 706587010931 Walker B; other site 706587010932 D-loop; other site 706587010933 H-loop/switch region; other site 706587010934 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 706587010935 Putative Fe-S cluster; Region: FeS; cl17515 706587010936 Uncharacterized conserved protein [Function unknown]; Region: COG1624 706587010937 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 706587010938 YbbR-like protein; Region: YbbR; pfam07949 706587010939 rod shape-determining protein MreB; Provisional; Region: PRK13930 706587010940 MreB and similar proteins; Region: MreB_like; cd10225 706587010941 nucleotide binding site [chemical binding]; other site 706587010942 Mg binding site [ion binding]; other site 706587010943 putative protofilament interaction site [polypeptide binding]; other site 706587010944 RodZ interaction site [polypeptide binding]; other site 706587010945 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 706587010946 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 706587010947 Nif-specific regulatory protein; Region: nifA; TIGR01817 706587010948 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 706587010949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587010950 Walker A motif; other site 706587010951 ATP binding site [chemical binding]; other site 706587010952 Walker B motif; other site 706587010953 arginine finger; other site 706587010954 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 706587010955 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 706587010956 Nitrogen regulatory protein P-II; Region: P-II; smart00938 706587010957 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 706587010958 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 706587010959 Nitrogen regulatory protein P-II; Region: P-II; smart00938 706587010960 glutamine synthetase, type I; Region: GlnA; TIGR00653 706587010961 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 706587010962 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 706587010963 NAD synthetase; Provisional; Region: PRK13981 706587010964 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 706587010965 multimer interface [polypeptide binding]; other site 706587010966 active site 706587010967 catalytic triad [active] 706587010968 protein interface 1 [polypeptide binding]; other site 706587010969 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 706587010970 homodimer interface [polypeptide binding]; other site 706587010971 NAD binding pocket [chemical binding]; other site 706587010972 ATP binding pocket [chemical binding]; other site 706587010973 Mg binding site [ion binding]; other site 706587010974 active-site loop [active] 706587010975 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 706587010976 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 706587010977 catalytic triad [active] 706587010978 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 706587010979 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 706587010980 active site 706587010981 dimer interface [polypeptide binding]; other site 706587010982 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 706587010983 Ligand Binding Site [chemical binding]; other site 706587010984 Molecular Tunnel; other site 706587010985 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 706587010986 Ligand binding site; other site 706587010987 Putative Catalytic site; other site 706587010988 DXD motif; other site 706587010989 TIGR04255 family protein; Region: sporadTIGR04255 706587010990 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 706587010991 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 706587010992 NADP-binding site; other site 706587010993 homotetramer interface [polypeptide binding]; other site 706587010994 substrate binding site [chemical binding]; other site 706587010995 homodimer interface [polypeptide binding]; other site 706587010996 active site 706587010997 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 706587010998 CoA-transferase family III; Region: CoA_transf_3; pfam02515 706587010999 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 706587011000 putative hydrophobic ligand binding site [chemical binding]; other site 706587011001 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 706587011002 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 706587011003 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 706587011004 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 706587011005 ribonuclease III; Reviewed; Region: rnc; PRK00102 706587011006 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 706587011007 dimerization interface [polypeptide binding]; other site 706587011008 active site 706587011009 metal binding site [ion binding]; metal-binding site 706587011010 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 706587011011 dsRNA binding site [nucleotide binding]; other site 706587011012 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 706587011013 aspartate aminotransferase; Provisional; Region: PRK05764 706587011014 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706587011015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587011016 homodimer interface [polypeptide binding]; other site 706587011017 catalytic residue [active] 706587011018 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 706587011019 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 706587011020 active site 706587011021 (T/H)XGH motif; other site 706587011022 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 706587011023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587011024 S-adenosylmethionine binding site [chemical binding]; other site 706587011025 Domain of unknown function DUF77; Region: DUF77; pfam01910 706587011026 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 706587011027 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 706587011028 nudix motif; other site 706587011029 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 706587011030 putative active site [active] 706587011031 dimerization interface [polypeptide binding]; other site 706587011032 putative tRNAtyr binding site [nucleotide binding]; other site 706587011033 Methyltransferase domain; Region: Methyltransf_31; pfam13847 706587011034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587011035 S-adenosylmethionine binding site [chemical binding]; other site 706587011036 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 706587011037 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706587011038 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 706587011039 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706587011040 active site 706587011041 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 706587011042 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587011043 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587011044 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706587011045 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706587011046 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587011047 Methyltransferase domain; Region: Methyltransf_23; pfam13489 706587011048 Methyltransferase domain; Region: Methyltransf_11; pfam08241 706587011049 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706587011050 active site 706587011051 Methyltransferase domain; Region: Methyltransf_23; pfam13489 706587011052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587011053 S-adenosylmethionine binding site [chemical binding]; other site 706587011054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 706587011055 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 706587011056 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 706587011057 Walker A/P-loop; other site 706587011058 ATP binding site [chemical binding]; other site 706587011059 Q-loop/lid; other site 706587011060 ABC transporter signature motif; other site 706587011061 Walker B; other site 706587011062 D-loop; other site 706587011063 H-loop/switch region; other site 706587011064 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 706587011065 putative carbohydrate binding site [chemical binding]; other site 706587011066 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 706587011067 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 706587011068 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 706587011069 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 706587011070 NAD binding site [chemical binding]; other site 706587011071 putative substrate binding site 2 [chemical binding]; other site 706587011072 putative substrate binding site 1 [chemical binding]; other site 706587011073 active site 706587011074 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 706587011075 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 706587011076 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 706587011077 inhibitor-cofactor binding pocket; inhibition site 706587011078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587011079 catalytic residue [active] 706587011080 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587011081 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 706587011082 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 706587011083 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 706587011084 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 706587011085 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 706587011086 Peptidase family M50; Region: Peptidase_M50; pfam02163 706587011087 active site 706587011088 putative substrate binding region [chemical binding]; other site 706587011089 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587011090 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587011091 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587011092 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587011093 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 706587011094 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 706587011095 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 706587011096 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706587011097 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 706587011098 active site 706587011099 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587011100 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587011101 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 706587011102 Protein of unknown function, DUF488; Region: DUF488; pfam04343 706587011103 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 706587011104 Methyltransferase domain; Region: Methyltransf_24; pfam13578 706587011105 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 706587011106 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 706587011107 Walker A/P-loop; other site 706587011108 ATP binding site [chemical binding]; other site 706587011109 Q-loop/lid; other site 706587011110 ABC transporter signature motif; other site 706587011111 Walker B; other site 706587011112 D-loop; other site 706587011113 H-loop/switch region; other site 706587011114 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 706587011115 putative carbohydrate binding site [chemical binding]; other site 706587011116 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 706587011117 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 706587011118 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 706587011119 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 706587011120 GAF domain; Region: GAF; pfam01590 706587011121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587011122 Walker A motif; other site 706587011123 ATP binding site [chemical binding]; other site 706587011124 Walker B motif; other site 706587011125 arginine finger; other site 706587011126 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587011127 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 706587011128 DNA methylase; Region: N6_N4_Mtase; pfam01555 706587011129 Methyltransferase domain; Region: Methyltransf_26; pfam13659 706587011130 DNA methylase; Region: N6_N4_Mtase; cl17433 706587011131 cytochrome c-550; Provisional; Region: psbV; cl17239 706587011132 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 706587011133 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587011134 substrate binding site [chemical binding]; other site 706587011135 oxyanion hole (OAH) forming residues; other site 706587011136 trimer interface [polypeptide binding]; other site 706587011137 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 706587011138 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 706587011139 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 706587011140 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 706587011141 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 706587011142 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 706587011143 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 706587011144 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 706587011145 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 706587011146 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 706587011147 HIGH motif; other site 706587011148 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 706587011149 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 706587011150 active site 706587011151 KMSKS motif; other site 706587011152 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 706587011153 tRNA binding surface [nucleotide binding]; other site 706587011154 anticodon binding site; other site 706587011155 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 706587011156 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 706587011157 FAD binding domain; Region: FAD_binding_4; pfam01565 706587011158 Berberine and berberine like; Region: BBE; pfam08031 706587011159 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 706587011160 thiamine phosphate binding site [chemical binding]; other site 706587011161 active site 706587011162 pyrophosphate binding site [ion binding]; other site 706587011163 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 706587011164 substrate binding site [chemical binding]; other site 706587011165 multimerization interface [polypeptide binding]; other site 706587011166 ATP binding site [chemical binding]; other site 706587011167 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587011168 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587011169 Walker A/P-loop; other site 706587011170 ATP binding site [chemical binding]; other site 706587011171 Q-loop/lid; other site 706587011172 ABC transporter signature motif; other site 706587011173 Walker B; other site 706587011174 D-loop; other site 706587011175 H-loop/switch region; other site 706587011176 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587011177 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587011178 Walker A/P-loop; other site 706587011179 ATP binding site [chemical binding]; other site 706587011180 Q-loop/lid; other site 706587011181 ABC transporter signature motif; other site 706587011182 Walker B; other site 706587011183 D-loop; other site 706587011184 H-loop/switch region; other site 706587011185 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 706587011186 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 706587011187 acyl-activating enzyme (AAE) consensus motif; other site 706587011188 putative AMP binding site [chemical binding]; other site 706587011189 putative active site [active] 706587011190 putative CoA binding site [chemical binding]; other site 706587011191 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587011192 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587011193 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587011194 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587011195 TM-ABC transporter signature motif; other site 706587011196 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587011197 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587011198 TM-ABC transporter signature motif; other site 706587011199 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 706587011200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587011201 Radical SAM superfamily; Region: Radical_SAM; pfam04055 706587011202 FeS/SAM binding site; other site 706587011203 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 706587011204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587011205 binding surface 706587011206 TPR repeat; Region: TPR_11; pfam13414 706587011207 TPR motif; other site 706587011208 TPR repeat; Region: TPR_11; pfam13414 706587011209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587011210 binding surface 706587011211 TPR motif; other site 706587011212 TPR repeat; Region: TPR_11; pfam13414 706587011213 elongation factor P; Validated; Region: PRK00529 706587011214 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 706587011215 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 706587011216 RNA binding site [nucleotide binding]; other site 706587011217 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 706587011218 RNA binding site [nucleotide binding]; other site 706587011219 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 706587011220 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 706587011221 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 706587011222 active site 706587011223 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 706587011224 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 706587011225 gamma subunit interface [polypeptide binding]; other site 706587011226 epsilon subunit interface [polypeptide binding]; other site 706587011227 LBP interface [polypeptide binding]; other site 706587011228 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 706587011229 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 706587011230 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 706587011231 alpha subunit interaction interface [polypeptide binding]; other site 706587011232 Walker A motif; other site 706587011233 ATP binding site [chemical binding]; other site 706587011234 Walker B motif; other site 706587011235 inhibitor binding site; inhibition site 706587011236 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 706587011237 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 706587011238 core domain interface [polypeptide binding]; other site 706587011239 delta subunit interface [polypeptide binding]; other site 706587011240 epsilon subunit interface [polypeptide binding]; other site 706587011241 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 706587011242 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 706587011243 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 706587011244 beta subunit interaction interface [polypeptide binding]; other site 706587011245 Walker A motif; other site 706587011246 ATP binding site [chemical binding]; other site 706587011247 Walker B motif; other site 706587011248 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 706587011249 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 706587011250 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 706587011251 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 706587011252 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 706587011253 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 706587011254 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 706587011255 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 706587011256 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 706587011257 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 706587011258 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 706587011259 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 706587011260 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 706587011261 rod shape-determining protein MreC; Provisional; Region: PRK13922 706587011262 rod shape-determining protein MreC; Region: MreC; pfam04085 706587011263 rod shape-determining protein MreB; Provisional; Region: PRK13927 706587011264 MreB and similar proteins; Region: MreB_like; cd10225 706587011265 nucleotide binding site [chemical binding]; other site 706587011266 Mg binding site [ion binding]; other site 706587011267 putative protofilament interaction site [polypeptide binding]; other site 706587011268 RodZ interaction site [polypeptide binding]; other site 706587011269 SurA N-terminal domain; Region: SurA_N_3; cl07813 706587011270 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 706587011271 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 706587011272 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 706587011273 Domain of unknown function DUF21; Region: DUF21; pfam01595 706587011274 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 706587011275 Transporter associated domain; Region: CorC_HlyC; smart01091 706587011276 ribosome maturation protein RimP; Reviewed; Region: PRK00092 706587011277 Sm and related proteins; Region: Sm_like; cl00259 706587011278 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 706587011279 putative oligomer interface [polypeptide binding]; other site 706587011280 putative RNA binding site [nucleotide binding]; other site 706587011281 NusA N-terminal domain; Region: NusA_N; pfam08529 706587011282 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 706587011283 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 706587011284 RNA binding site [nucleotide binding]; other site 706587011285 homodimer interface [polypeptide binding]; other site 706587011286 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 706587011287 G-X-X-G motif; other site 706587011288 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 706587011289 G-X-X-G motif; other site 706587011290 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 706587011291 putative RNA binding cleft [nucleotide binding]; other site 706587011292 translation initiation factor IF-2; Region: IF-2; TIGR00487 706587011293 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 706587011294 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 706587011295 G1 box; other site 706587011296 putative GEF interaction site [polypeptide binding]; other site 706587011297 GTP/Mg2+ binding site [chemical binding]; other site 706587011298 Switch I region; other site 706587011299 G2 box; other site 706587011300 G3 box; other site 706587011301 Switch II region; other site 706587011302 G4 box; other site 706587011303 G5 box; other site 706587011304 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 706587011305 Translation-initiation factor 2; Region: IF-2; pfam11987 706587011306 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 706587011307 Protein of unknown function (DUF503); Region: DUF503; pfam04456 706587011308 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 706587011309 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 706587011310 DHH family; Region: DHH; pfam01368 706587011311 DHHA1 domain; Region: DHHA1; pfam02272 706587011312 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 706587011313 putative homodimer interface [polypeptide binding]; other site 706587011314 putative active site pocket [active] 706587011315 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 706587011316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587011317 active site 706587011318 phosphorylation site [posttranslational modification] 706587011319 intermolecular recognition site; other site 706587011320 dimerization interface [polypeptide binding]; other site 706587011321 putative acyltransferase; Provisional; Region: PRK05790 706587011322 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 706587011323 dimer interface [polypeptide binding]; other site 706587011324 active site 706587011325 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 706587011326 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 706587011327 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 706587011328 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 706587011329 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 706587011330 intersubunit interface [polypeptide binding]; other site 706587011331 active site 706587011332 zinc binding site [ion binding]; other site 706587011333 Na+ binding site [ion binding]; other site 706587011334 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 706587011335 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706587011336 active site 706587011337 ParB-like nuclease domain; Region: ParB; smart00470 706587011338 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 706587011339 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 706587011340 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587011341 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 706587011342 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 706587011343 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 706587011344 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 706587011345 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 706587011346 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 706587011347 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 706587011348 inhibitor-cofactor binding pocket; inhibition site 706587011349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587011350 catalytic residue [active] 706587011351 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 706587011352 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 706587011353 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 706587011354 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 706587011355 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 706587011356 B12 binding site [chemical binding]; other site 706587011357 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 706587011358 HflC protein; Region: hflC; TIGR01932 706587011359 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 706587011360 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 706587011361 HflK protein; Region: hflK; TIGR01933 706587011362 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587011363 fumarate hydratase; Reviewed; Region: fumC; PRK00485 706587011364 Class II fumarases; Region: Fumarase_classII; cd01362 706587011365 active site 706587011366 tetramer interface [polypeptide binding]; other site 706587011367 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 706587011368 TPP-binding site [chemical binding]; other site 706587011369 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 706587011370 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 706587011371 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 706587011372 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 706587011373 dimer interface [polypeptide binding]; other site 706587011374 PYR/PP interface [polypeptide binding]; other site 706587011375 TPP binding site [chemical binding]; other site 706587011376 substrate binding site [chemical binding]; other site 706587011377 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706587011378 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 706587011379 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587011380 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 706587011381 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706587011382 4Fe-4S binding domain; Region: Fer4; pfam00037 706587011383 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706587011384 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587011385 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587011386 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 706587011387 active site 706587011388 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 706587011389 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 706587011390 Domain of unknown function (DUF373); Region: DUF373; cl12079 706587011391 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 706587011392 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 706587011393 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 706587011394 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 706587011395 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 706587011396 active site 706587011397 metal binding site [ion binding]; metal-binding site 706587011398 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 706587011399 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 706587011400 active site 706587011401 dimerization interface [polypeptide binding]; other site 706587011402 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 706587011403 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 706587011404 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 706587011405 active site 706587011406 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 706587011407 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 706587011408 5S rRNA interface [nucleotide binding]; other site 706587011409 CTC domain interface [polypeptide binding]; other site 706587011410 L16 interface [polypeptide binding]; other site 706587011411 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 706587011412 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 706587011413 active site 706587011414 DNA binding site [nucleotide binding] 706587011415 LexA repressor; Validated; Region: PRK00215 706587011416 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 706587011417 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 706587011418 Catalytic site [active] 706587011419 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 706587011420 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 706587011421 TMP-binding site; other site 706587011422 ATP-binding site [chemical binding]; other site 706587011423 GTPase Era; Reviewed; Region: era; PRK00089 706587011424 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 706587011425 G1 box; other site 706587011426 GTP/Mg2+ binding site [chemical binding]; other site 706587011427 Switch I region; other site 706587011428 G2 box; other site 706587011429 Switch II region; other site 706587011430 G3 box; other site 706587011431 G4 box; other site 706587011432 G5 box; other site 706587011433 KH domain; Region: KH_2; pfam07650 706587011434 Uncharacterized conserved protein [Function unknown]; Region: COG2006 706587011435 Domain of unknown function (DUF362); Region: DUF362; pfam04015 706587011436 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 706587011437 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 706587011438 active site 706587011439 catalytic site [active] 706587011440 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 706587011441 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 706587011442 active site 706587011443 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 706587011444 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 706587011445 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 706587011446 homodimer interface [polypeptide binding]; other site 706587011447 metal binding site [ion binding]; metal-binding site 706587011448 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 706587011449 homodimer interface [polypeptide binding]; other site 706587011450 active site 706587011451 putative chemical substrate binding site [chemical binding]; other site 706587011452 metal binding site [ion binding]; metal-binding site 706587011453 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 706587011454 PhoH-like protein; Region: PhoH; pfam02562 706587011455 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 706587011456 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 706587011457 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587011458 Zn2+ binding site [ion binding]; other site 706587011459 Mg2+ binding site [ion binding]; other site 706587011460 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 706587011461 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 706587011462 diiron binding motif [ion binding]; other site 706587011463 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 706587011464 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 706587011465 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 706587011466 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 706587011467 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 706587011468 Walker A/P-loop; other site 706587011469 ATP binding site [chemical binding]; other site 706587011470 Q-loop/lid; other site 706587011471 ABC transporter signature motif; other site 706587011472 Walker B; other site 706587011473 D-loop; other site 706587011474 H-loop/switch region; other site 706587011475 HlyD family secretion protein; Region: HlyD; pfam00529 706587011476 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587011477 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587011478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587011479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587011480 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 706587011481 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 706587011482 FAD binding site [chemical binding]; other site 706587011483 homotetramer interface [polypeptide binding]; other site 706587011484 substrate binding pocket [chemical binding]; other site 706587011485 catalytic base [active] 706587011486 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 706587011487 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 706587011488 Walker A; other site 706587011489 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 706587011490 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 706587011491 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 706587011492 active site 706587011493 Family of unknown function (DUF3836); Region: DUF3836; pfam12930 706587011494 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 706587011495 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 706587011496 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 706587011497 active site 706587011498 dimer interface [polypeptide binding]; other site 706587011499 effector binding site; other site 706587011500 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 706587011501 TSCPD domain; Region: TSCPD; pfam12637 706587011502 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 706587011503 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 706587011504 active site 706587011505 catalytic motif [active] 706587011506 Zn binding site [ion binding]; other site 706587011507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 706587011508 Coenzyme A binding pocket [chemical binding]; other site 706587011509 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 706587011510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587011511 Coenzyme A binding pocket [chemical binding]; other site 706587011512 MarR family; Region: MarR_2; cl17246 706587011513 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 706587011514 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 706587011515 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 706587011516 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 706587011517 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 706587011518 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587011519 FeS/SAM binding site; other site 706587011520 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 706587011521 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 706587011522 substrate binding site [chemical binding]; other site 706587011523 hexamer interface [polypeptide binding]; other site 706587011524 metal binding site [ion binding]; metal-binding site 706587011525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587011526 binding surface 706587011527 TPR motif; other site 706587011528 TPR repeat; Region: TPR_11; pfam13414 706587011529 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587011530 binding surface 706587011531 TPR motif; other site 706587011532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587011533 binding surface 706587011534 TPR motif; other site 706587011535 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 706587011536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587011537 binding surface 706587011538 TPR motif; other site 706587011539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587011540 TPR motif; other site 706587011541 binding surface 706587011542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587011543 TPR motif; other site 706587011544 TPR repeat; Region: TPR_11; pfam13414 706587011545 binding surface 706587011546 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 706587011547 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 706587011548 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 706587011549 putative dimer interface [polypeptide binding]; other site 706587011550 chaperone protein DnaJ; Provisional; Region: PRK14299 706587011551 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 706587011552 HSP70 interaction site [polypeptide binding]; other site 706587011553 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 706587011554 substrate binding site [polypeptide binding]; other site 706587011555 dimer interface [polypeptide binding]; other site 706587011556 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 706587011557 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 706587011558 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 706587011559 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587011560 Zn2+ binding site [ion binding]; other site 706587011561 Mg2+ binding site [ion binding]; other site 706587011562 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 706587011563 synthetase active site [active] 706587011564 NTP binding site [chemical binding]; other site 706587011565 metal binding site [ion binding]; metal-binding site 706587011566 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 706587011567 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 706587011568 GTP-binding protein Der; Reviewed; Region: PRK00093 706587011569 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 706587011570 G1 box; other site 706587011571 GTP/Mg2+ binding site [chemical binding]; other site 706587011572 Switch I region; other site 706587011573 G2 box; other site 706587011574 Switch II region; other site 706587011575 G3 box; other site 706587011576 G4 box; other site 706587011577 G5 box; other site 706587011578 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 706587011579 G1 box; other site 706587011580 GTP/Mg2+ binding site [chemical binding]; other site 706587011581 Switch I region; other site 706587011582 G2 box; other site 706587011583 G3 box; other site 706587011584 Switch II region; other site 706587011585 G4 box; other site 706587011586 G5 box; other site 706587011587 Peptidase family M48; Region: Peptidase_M48; pfam01435 706587011588 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 706587011589 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 706587011590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706587011591 active site 706587011592 motif I; other site 706587011593 motif II; other site 706587011594 Flagellin N-methylase; Region: FliB; pfam03692 706587011595 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 706587011596 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 706587011597 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 706587011598 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 706587011599 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 706587011600 HIGH motif; other site 706587011601 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 706587011602 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 706587011603 active site 706587011604 KMSKS motif; other site 706587011605 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 706587011606 tRNA binding surface [nucleotide binding]; other site 706587011607 Lipopolysaccharide-assembly; Region: LptE; pfam04390 706587011608 Q-cell neuroblast polarisation; Region: Dpy19; pfam10034 706587011609 malate dehydrogenase; Reviewed; Region: PRK06223 706587011610 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 706587011611 NAD(P) binding site [chemical binding]; other site 706587011612 dimer interface [polypeptide binding]; other site 706587011613 tetramer (dimer of dimers) interface [polypeptide binding]; other site 706587011614 substrate binding site [chemical binding]; other site 706587011615 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 706587011616 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 706587011617 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587011618 FeS/SAM binding site; other site 706587011619 TRAM domain; Region: TRAM; pfam01938 706587011620 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 706587011621 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 706587011622 active site 706587011623 oxyanion hole [active] 706587011624 SEA domain; Region: SEA; cl02507 706587011625 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 706587011626 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 706587011627 23S rRNA binding site [nucleotide binding]; other site 706587011628 L21 binding site [polypeptide binding]; other site 706587011629 L13 binding site [polypeptide binding]; other site 706587011630 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 706587011631 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 706587011632 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 706587011633 dimer interface [polypeptide binding]; other site 706587011634 motif 1; other site 706587011635 active site 706587011636 motif 2; other site 706587011637 motif 3; other site 706587011638 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 706587011639 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 706587011640 putative tRNA-binding site [nucleotide binding]; other site 706587011641 B3/4 domain; Region: B3_4; pfam03483 706587011642 tRNA synthetase B5 domain; Region: B5; pfam03484 706587011643 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 706587011644 dimer interface [polypeptide binding]; other site 706587011645 motif 1; other site 706587011646 motif 3; other site 706587011647 motif 2; other site 706587011648 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 706587011649 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 706587011650 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 706587011651 DNA binding residues [nucleotide binding] 706587011652 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706587011653 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 706587011654 dimer interface [polypeptide binding]; other site 706587011655 substrate binding site [chemical binding]; other site 706587011656 metal binding site [ion binding]; metal-binding site 706587011657 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 706587011658 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 706587011659 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 706587011660 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 706587011661 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 706587011662 active site 706587011663 ATP binding site [chemical binding]; other site 706587011664 substrate binding site [chemical binding]; other site 706587011665 activation loop (A-loop); other site 706587011666 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706587011667 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 706587011668 ligand binding site [chemical binding]; other site 706587011669 flexible hinge region; other site 706587011670 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 706587011671 active site 706587011672 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 706587011673 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587011674 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 706587011675 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 706587011676 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587011677 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 706587011678 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 706587011679 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587011680 Cysteine-rich domain; Region: CCG; pfam02754 706587011681 Cysteine-rich domain; Region: CCG; pfam02754 706587011682 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 706587011683 spermidine synthase; Provisional; Region: PRK00811 706587011684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587011685 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 706587011686 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 706587011687 aspartate aminotransferase; Provisional; Region: PRK05764 706587011688 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706587011689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587011690 homodimer interface [polypeptide binding]; other site 706587011691 catalytic residue [active] 706587011692 RNA methyltransferase, RsmE family; Region: TIGR00046 706587011693 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 706587011694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587011695 TPR motif; other site 706587011696 binding surface 706587011697 TPR repeat; Region: TPR_11; pfam13414 706587011698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587011699 TPR repeat; Region: TPR_11; pfam13414 706587011700 binding surface 706587011701 TPR motif; other site 706587011702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587011703 binding surface 706587011704 TPR motif; other site 706587011705 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587011706 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 706587011707 Catalytic domain of Protein Kinases; Region: PKc; cd00180 706587011708 active site 706587011709 ATP binding site [chemical binding]; other site 706587011710 substrate binding site [chemical binding]; other site 706587011711 activation loop (A-loop); other site 706587011712 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 706587011713 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 706587011714 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 706587011715 ABC transporter; Region: ABC_tran_2; pfam12848 706587011716 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 706587011717 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 706587011718 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 706587011719 Ligand Binding Site [chemical binding]; other site 706587011720 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 706587011721 Lumazine binding domain; Region: Lum_binding; pfam00677 706587011722 Lumazine binding domain; Region: Lum_binding; pfam00677 706587011723 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 706587011724 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 706587011725 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 706587011726 dimerization interface [polypeptide binding]; other site 706587011727 active site 706587011728 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 706587011729 homopentamer interface [polypeptide binding]; other site 706587011730 active site 706587011731 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 706587011732 putative RNA binding site [nucleotide binding]; other site 706587011733 large tegument protein UL36; Provisional; Region: PHA03247 706587011734 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 706587011735 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 706587011736 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587011737 FeS/SAM binding site; other site 706587011738 selenocysteine synthase; Provisional; Region: PRK04311 706587011739 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 706587011740 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 706587011741 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706587011742 catalytic residue [active] 706587011743 Major royal jelly protein; Region: MRJP; pfam03022 706587011744 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 706587011745 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 706587011746 RNA binding surface [nucleotide binding]; other site 706587011747 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 706587011748 active site 706587011749 agmatinase; Region: agmatinase; TIGR01230 706587011750 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 706587011751 putative active site [active] 706587011752 Mn binding site [ion binding]; other site 706587011753 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 706587011754 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 706587011755 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 706587011756 protein binding site [polypeptide binding]; other site 706587011757 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 706587011758 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 706587011759 catalytic site [active] 706587011760 G-X2-G-X-G-K; other site 706587011761 4Fe-4S binding domain; Region: Fer4_5; pfam12801 706587011762 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587011763 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 706587011764 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 706587011765 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 706587011766 glycine cleavage system protein H; Provisional; Region: PRK13380 706587011767 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 706587011768 lipoyl attachment site [posttranslational modification]; other site 706587011769 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 706587011770 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 706587011771 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706587011772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587011773 homodimer interface [polypeptide binding]; other site 706587011774 catalytic residue [active] 706587011775 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 706587011776 anti sigma factor interaction site; other site 706587011777 regulatory phosphorylation site [posttranslational modification]; other site 706587011778 Cache domain; Region: Cache_1; pfam02743 706587011779 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587011780 dimerization interface [polypeptide binding]; other site 706587011781 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 706587011782 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 706587011783 Putative Fe-S cluster; Region: FeS; cl17515 706587011784 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 706587011785 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 706587011786 active site 706587011787 ATP binding site [chemical binding]; other site 706587011788 substrate binding site [chemical binding]; other site 706587011789 activation loop (A-loop); other site 706587011790 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 706587011791 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706587011792 ligand binding site [chemical binding]; other site 706587011793 flexible hinge region; other site 706587011794 Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133 706587011795 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 706587011796 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 706587011797 active site 706587011798 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 706587011799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587011800 S-adenosylmethionine binding site [chemical binding]; other site 706587011801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 706587011802 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 706587011803 Domain of unknown function (DUF955); Region: DUF955; cl01076 706587011804 Methyltransferase domain; Region: Methyltransf_23; pfam13489 706587011805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587011806 S-adenosylmethionine binding site [chemical binding]; other site 706587011807 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706587011808 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 706587011809 substrate binding site [chemical binding]; other site 706587011810 ATP binding site [chemical binding]; other site 706587011811 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4030 706587011812 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 706587011813 active site residue [active] 706587011814 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 706587011815 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 706587011816 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 706587011817 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587011818 FeS/SAM binding site; other site 706587011819 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 706587011820 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587011821 catalytic loop [active] 706587011822 iron binding site [ion binding]; other site 706587011823 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 706587011824 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 706587011825 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 706587011826 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 706587011827 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 706587011828 CoenzymeA binding site [chemical binding]; other site 706587011829 subunit interaction site [polypeptide binding]; other site 706587011830 PHB binding site; other site 706587011831 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587011832 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 706587011833 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 706587011834 oligomer interface [polypeptide binding]; other site 706587011835 metal binding site [ion binding]; metal-binding site 706587011836 metal binding site [ion binding]; metal-binding site 706587011837 Cl binding site [ion binding]; other site 706587011838 aspartate ring; other site 706587011839 basic sphincter; other site 706587011840 putative hydrophobic gate; other site 706587011841 periplasmic entrance; other site 706587011842 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 706587011843 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587011844 catalytic loop [active] 706587011845 iron binding site [ion binding]; other site 706587011846 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587011847 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 706587011848 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587011849 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587011850 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 706587011851 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 706587011852 FOG: CBS domain [General function prediction only]; Region: COG0517 706587011853 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 706587011854 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 706587011855 Response regulator receiver domain; Region: Response_reg; pfam00072 706587011856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587011857 active site 706587011858 phosphorylation site [posttranslational modification] 706587011859 intermolecular recognition site; other site 706587011860 dimerization interface [polypeptide binding]; other site 706587011861 Sporulation related domain; Region: SPOR; pfam05036 706587011862 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 706587011863 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 706587011864 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 706587011865 active site 706587011866 HIGH motif; other site 706587011867 KMSK motif region; other site 706587011868 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 706587011869 tRNA binding surface [nucleotide binding]; other site 706587011870 anticodon binding site; other site 706587011871 Vanadium-binding protein 2; Region: Vanabin-2; pfam11437 706587011872 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587011873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587011874 active site 706587011875 phosphorylation site [posttranslational modification] 706587011876 intermolecular recognition site; other site 706587011877 dimerization interface [polypeptide binding]; other site 706587011878 PAS fold; Region: PAS; pfam00989 706587011879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587011880 putative active site [active] 706587011881 heme pocket [chemical binding]; other site 706587011882 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587011883 PAS domain; Region: PAS_9; pfam13426 706587011884 putative active site [active] 706587011885 heme pocket [chemical binding]; other site 706587011886 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 706587011887 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706587011888 DNA binding residues [nucleotide binding] 706587011889 dimerization interface [polypeptide binding]; other site 706587011890 Bacterial SH3 domain; Region: SH3_3; pfam08239 706587011891 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 706587011892 Ribonuclease P; Region: Ribonuclease_P; pfam00825 706587011893 Haemolytic domain; Region: Haemolytic; pfam01809 706587011894 membrane protein insertase; Provisional; Region: PRK01318 706587011895 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 706587011896 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 706587011897 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 706587011898 G-X-X-G motif; other site 706587011899 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 706587011900 RxxxH motif; other site 706587011901 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 706587011902 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 706587011903 trmE is a tRNA modification GTPase; Region: trmE; cd04164 706587011904 G1 box; other site 706587011905 GTP/Mg2+ binding site [chemical binding]; other site 706587011906 Switch I region; other site 706587011907 G2 box; other site 706587011908 Switch II region; other site 706587011909 G3 box; other site 706587011910 G4 box; other site 706587011911 G5 box; other site 706587011912 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 706587011913 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 706587011914 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 706587011915 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 706587011916 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 706587011917 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 706587011918 carboxyltransferase (CT) interaction site; other site 706587011919 biotinylation site [posttranslational modification]; other site 706587011920 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 706587011921 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 706587011922 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 706587011923 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 706587011924 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587011925 non-specific DNA binding site [nucleotide binding]; other site 706587011926 salt bridge; other site 706587011927 sequence-specific DNA binding site [nucleotide binding]; other site 706587011928 Predicted transcriptional regulator [Transcription]; Region: COG2932 706587011929 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 706587011930 Catalytic site [active] 706587011931 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 706587011932 N-acetyl-D-glucosamine binding site [chemical binding]; other site 706587011933 catalytic residue [active] 706587011934 SdpI/YhfL protein family; Region: SdpI; pfam13630 706587011935 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 706587011936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587011937 non-specific DNA binding site [nucleotide binding]; other site 706587011938 salt bridge; other site 706587011939 sequence-specific DNA binding site [nucleotide binding]; other site 706587011940 Cupin domain; Region: Cupin_2; cl17218 706587011941 O-Antigen ligase; Region: Wzy_C; pfam04932 706587011942 Ferredoxin [Energy production and conversion]; Region: COG1146 706587011943 4Fe-4S binding domain; Region: Fer4_6; pfam12837 706587011944 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 706587011945 putative FMN binding site [chemical binding]; other site 706587011946 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 706587011947 Methyltransferase domain; Region: Methyltransf_26; pfam13659 706587011948 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 706587011949 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 706587011950 Uncharacterized conserved protein [Function unknown]; Region: COG1262 706587011951 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 706587011952 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 706587011953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587011954 S-adenosylmethionine binding site [chemical binding]; other site 706587011955 PAS fold; Region: PAS; pfam00989 706587011956 PAS domain S-box; Region: sensory_box; TIGR00229 706587011957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587011958 putative active site [active] 706587011959 heme pocket [chemical binding]; other site 706587011960 PAS fold; Region: PAS_4; pfam08448 706587011961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587011962 putative active site [active] 706587011963 heme pocket [chemical binding]; other site 706587011964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587011965 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587011966 Walker A motif; other site 706587011967 ATP binding site [chemical binding]; other site 706587011968 Walker B motif; other site 706587011969 arginine finger; other site 706587011970 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 706587011971 NMT1/THI5 like; Region: NMT1; pfam09084 706587011972 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 706587011973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 706587011974 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 706587011975 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 706587011976 Walker A/P-loop; other site 706587011977 ATP binding site [chemical binding]; other site 706587011978 Q-loop/lid; other site 706587011979 ABC transporter signature motif; other site 706587011980 Walker B; other site 706587011981 D-loop; other site 706587011982 H-loop/switch region; other site 706587011983 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 706587011984 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 706587011985 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587011986 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587011987 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587011988 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587011989 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587011990 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587011991 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587011992 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706587011993 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587011994 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587011995 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 706587011996 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 706587011997 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587011998 FeS/SAM binding site; other site 706587011999 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 706587012000 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 706587012001 NAD binding site [chemical binding]; other site 706587012002 dimer interface [polypeptide binding]; other site 706587012003 substrate binding site [chemical binding]; other site 706587012004 tetramer (dimer of dimers) interface [polypeptide binding]; other site 706587012005 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 706587012006 rRNA interaction site [nucleotide binding]; other site 706587012007 S8 interaction site; other site 706587012008 putative laminin-1 binding site; other site 706587012009 elongation factor Ts; Reviewed; Region: tsf; PRK12332 706587012010 UBA/TS-N domain; Region: UBA; pfam00627 706587012011 Elongation factor TS; Region: EF_TS; pfam00889 706587012012 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 706587012013 putative nucleotide binding site [chemical binding]; other site 706587012014 uridine monophosphate binding site [chemical binding]; other site 706587012015 homohexameric interface [polypeptide binding]; other site 706587012016 ribosome recycling factor; Reviewed; Region: frr; PRK00083 706587012017 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 706587012018 hinge region; other site 706587012019 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 706587012020 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 706587012021 catalytic residue [active] 706587012022 putative FPP diphosphate binding site; other site 706587012023 putative FPP binding hydrophobic cleft; other site 706587012024 dimer interface [polypeptide binding]; other site 706587012025 putative IPP diphosphate binding site; other site 706587012026 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 706587012027 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 706587012028 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 706587012029 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 706587012030 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 706587012031 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 706587012032 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 706587012033 active site 706587012034 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 706587012035 active site 2 [active] 706587012036 active site 1 [active] 706587012037 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 706587012038 DHH family; Region: DHH; pfam01368 706587012039 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 706587012040 oxidoreductase family protein; Region: PLN02928 706587012041 putative ligand binding site [chemical binding]; other site 706587012042 putative NAD binding site [chemical binding]; other site 706587012043 catalytic site [active] 706587012044 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 706587012045 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 706587012046 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 706587012047 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 706587012048 dimer interface [polypeptide binding]; other site 706587012049 motif 1; other site 706587012050 active site 706587012051 motif 2; other site 706587012052 motif 3; other site 706587012053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587012054 TPR repeat; Region: TPR_11; pfam13414 706587012055 binding surface 706587012056 TPR motif; other site 706587012057 TPR repeat; Region: TPR_11; pfam13414 706587012058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587012059 binding surface 706587012060 TPR motif; other site 706587012061 TPR repeat; Region: TPR_11; pfam13414 706587012062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587012063 binding surface 706587012064 TPR motif; other site 706587012065 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 706587012066 4Fe-4S binding domain; Region: Fer4; pfam00037 706587012067 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587012068 Nitroreductase family; Region: Nitroreductase; pfam00881 706587012069 FMN binding site [chemical binding]; other site 706587012070 dimer interface [polypeptide binding]; other site 706587012071 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587012072 hypothetical protein; Provisional; Region: PRK07233 706587012073 cation transport regulator; Reviewed; Region: chaB; PRK09582 706587012074 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 706587012075 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 706587012076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706587012077 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706587012078 DNA binding residues [nucleotide binding] 706587012079 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 706587012080 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 706587012081 RNA binding surface [nucleotide binding]; other site 706587012082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587012083 S-adenosylmethionine binding site [chemical binding]; other site 706587012084 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 706587012085 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 706587012086 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 706587012087 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 706587012088 putative active site [active] 706587012089 putative metal binding site [ion binding]; other site 706587012090 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 706587012091 active site 706587012092 metal binding site [ion binding]; metal-binding site 706587012093 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 706587012094 intracellular protease, PfpI family; Region: PfpI; TIGR01382 706587012095 proposed catalytic triad [active] 706587012096 conserved cys residue [active] 706587012097 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 706587012098 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 706587012099 active site 706587012100 HIGH motif; other site 706587012101 dimer interface [polypeptide binding]; other site 706587012102 KMSKS motif; other site 706587012103 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 706587012104 RNA binding surface [nucleotide binding]; other site 706587012105 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 706587012106 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 706587012107 Recombination protein O N terminal; Region: RecO_N; pfam11967 706587012108 Recombination protein O C terminal; Region: RecO_C; pfam02565 706587012109 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 706587012110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587012111 Walker A motif; other site 706587012112 ATP binding site [chemical binding]; other site 706587012113 Walker B motif; other site 706587012114 arginine finger; other site 706587012115 transcription termination factor Rho; Provisional; Region: rho; PRK09376 706587012116 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 706587012117 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 706587012118 RNA binding site [nucleotide binding]; other site 706587012119 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 706587012120 multimer interface [polypeptide binding]; other site 706587012121 Walker A motif; other site 706587012122 ATP binding site [chemical binding]; other site 706587012123 Walker B motif; other site 706587012124 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 706587012125 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 706587012126 peptide chain release factor 1; Validated; Region: prfA; PRK00591 706587012127 This domain is found in peptide chain release factors; Region: PCRF; smart00937 706587012128 RF-1 domain; Region: RF-1; pfam00472 706587012129 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 706587012130 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 706587012131 active site 706587012132 Riboflavin kinase; Region: Flavokinase; pfam01687 706587012133 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 706587012134 nucleotide binding site/active site [active] 706587012135 HIT family signature motif; other site 706587012136 catalytic residue [active] 706587012137 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 706587012138 active site 706587012139 metal binding site [ion binding]; metal-binding site 706587012140 homotetramer interface [polypeptide binding]; other site 706587012141 hypothetical protein; Provisional; Region: PRK04334 706587012142 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 706587012143 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 706587012144 dimer interface [polypeptide binding]; other site 706587012145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587012146 catalytic residue [active] 706587012147 Transcriptional regulator; Region: Rrf2; cl17282 706587012148 Rrf2 family protein; Region: rrf2_super; TIGR00738 706587012149 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 706587012150 Ligand binding site [chemical binding]; other site 706587012151 Electron transfer flavoprotein domain; Region: ETF; pfam01012 706587012152 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 706587012153 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 706587012154 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 706587012155 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587012156 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587012157 binding surface 706587012158 TPR motif; other site 706587012159 TPR repeat; Region: TPR_11; pfam13414 706587012160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587012161 TPR motif; other site 706587012162 binding surface 706587012163 TPR repeat; Region: TPR_11; pfam13414 706587012164 TPR repeat; Region: TPR_11; pfam13414 706587012165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587012166 TPR motif; other site 706587012167 binding surface 706587012168 TPR repeat; Region: TPR_11; pfam13414 706587012169 TPR repeat; Region: TPR_11; pfam13414 706587012170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587012171 TPR motif; other site 706587012172 binding surface 706587012173 TPR repeat; Region: TPR_11; pfam13414 706587012174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587012175 TPR motif; other site 706587012176 binding surface 706587012177 TPR repeat; Region: TPR_11; pfam13414 706587012178 TPR repeat; Region: TPR_11; pfam13414 706587012179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587012180 TPR motif; other site 706587012181 binding surface 706587012182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587012183 binding surface 706587012184 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587012185 TPR motif; other site 706587012186 Predicted integral membrane protein [Function unknown]; Region: COG5617 706587012187 TPR repeat; Region: TPR_11; pfam13414 706587012188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587012189 binding surface 706587012190 TPR motif; other site 706587012191 TPR repeat; Region: TPR_11; pfam13414 706587012192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587012193 binding surface 706587012194 TPR motif; other site 706587012195 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587012196 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 706587012197 putative active site [active] 706587012198 putative metal binding residues [ion binding]; other site 706587012199 signature motif; other site 706587012200 putative triphosphate binding site [ion binding]; other site 706587012201 dimer interface [polypeptide binding]; other site 706587012202 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 706587012203 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 706587012204 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 706587012205 active site 706587012206 NTP binding site [chemical binding]; other site 706587012207 metal binding triad [ion binding]; metal-binding site 706587012208 antibiotic binding site [chemical binding]; other site 706587012209 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 706587012210 LabA_like proteins; Region: LabA_like; cd06167 706587012211 putative metal binding site [ion binding]; other site 706587012212 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 706587012213 SmpB-tmRNA interface; other site 706587012214 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 706587012215 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 706587012216 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 706587012217 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 706587012218 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 706587012219 dimerization domain swap beta strand [polypeptide binding]; other site 706587012220 regulatory protein interface [polypeptide binding]; other site 706587012221 active site 706587012222 regulatory phosphorylation site [posttranslational modification]; other site 706587012223 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 706587012224 Response regulator receiver domain; Region: Response_reg; pfam00072 706587012225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587012226 active site 706587012227 phosphorylation site [posttranslational modification] 706587012228 intermolecular recognition site; other site 706587012229 dimerization interface [polypeptide binding]; other site 706587012230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 706587012231 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 706587012232 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 706587012233 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 706587012234 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 706587012235 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 706587012236 CoA-ligase; Region: Ligase_CoA; pfam00549 706587012237 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 706587012238 CoA binding domain; Region: CoA_binding; smart00881 706587012239 CoA-ligase; Region: Ligase_CoA; pfam00549 706587012240 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 706587012241 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 706587012242 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 706587012243 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 706587012244 B12 binding site [chemical binding]; other site 706587012245 cobalt ligand [ion binding]; other site 706587012246 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 706587012247 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 706587012248 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 706587012249 oligomerization interface [polypeptide binding]; other site 706587012250 active site 706587012251 metal binding site [ion binding]; metal-binding site 706587012252 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 706587012253 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 706587012254 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 706587012255 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 706587012256 catalytic motif [active] 706587012257 Zn binding site [ion binding]; other site 706587012258 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 706587012259 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 706587012260 ATP-sulfurylase; Region: ATPS; cd00517 706587012261 active site 706587012262 HXXH motif; other site 706587012263 flexible loop; other site 706587012264 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 706587012265 16S/18S rRNA binding site [nucleotide binding]; other site 706587012266 S13e-L30e interaction site [polypeptide binding]; other site 706587012267 25S rRNA binding site [nucleotide binding]; other site 706587012268 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 706587012269 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 706587012270 RNase E interface [polypeptide binding]; other site 706587012271 trimer interface [polypeptide binding]; other site 706587012272 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 706587012273 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 706587012274 RNase E interface [polypeptide binding]; other site 706587012275 trimer interface [polypeptide binding]; other site 706587012276 active site 706587012277 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 706587012278 putative nucleic acid binding region [nucleotide binding]; other site 706587012279 G-X-X-G motif; other site 706587012280 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 706587012281 RNA binding site [nucleotide binding]; other site 706587012282 domain interface; other site 706587012283 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 706587012284 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 706587012285 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 706587012286 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587012287 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 706587012288 IHF dimer interface [polypeptide binding]; other site 706587012289 IHF - DNA interface [nucleotide binding]; other site 706587012290 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 706587012291 IHF dimer interface [polypeptide binding]; other site 706587012292 IHF - DNA interface [nucleotide binding]; other site 706587012293 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587012294 Ankyrin repeat; Region: Ank; pfam00023 706587012295 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587012296 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587012297 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587012298 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587012299 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587012300 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587012301 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587012302 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 706587012303 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 706587012304 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587012305 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587012306 TM-ABC transporter signature motif; other site 706587012307 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587012308 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587012309 TM-ABC transporter signature motif; other site 706587012310 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587012311 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 706587012312 putative ligand binding site [chemical binding]; other site 706587012313 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587012314 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587012315 Walker A/P-loop; other site 706587012316 ATP binding site [chemical binding]; other site 706587012317 Q-loop/lid; other site 706587012318 ABC transporter signature motif; other site 706587012319 Walker B; other site 706587012320 D-loop; other site 706587012321 H-loop/switch region; other site 706587012322 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587012323 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587012324 Walker A/P-loop; other site 706587012325 ATP binding site [chemical binding]; other site 706587012326 Q-loop/lid; other site 706587012327 ABC transporter signature motif; other site 706587012328 Walker B; other site 706587012329 D-loop; other site 706587012330 H-loop/switch region; other site 706587012331 Putative cyclase; Region: Cyclase; pfam04199 706587012332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587012333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587012334 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 706587012335 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 706587012336 active site 706587012337 HIGH motif; other site 706587012338 nucleotide binding site [chemical binding]; other site 706587012339 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 706587012340 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 706587012341 active site 706587012342 KMSKS motif; other site 706587012343 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 706587012344 tRNA binding surface [nucleotide binding]; other site 706587012345 anticodon binding site; other site 706587012346 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 706587012347 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 706587012348 lipoprotein signal peptidase; Provisional; Region: PRK14787 706587012349 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 706587012350 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 706587012351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587012352 S-adenosylmethionine binding site [chemical binding]; other site 706587012353 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 706587012354 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 706587012355 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 706587012356 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 706587012357 active site 706587012358 PAS domain; Region: PAS_9; pfam13426 706587012359 PAS domain S-box; Region: sensory_box; TIGR00229 706587012360 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587012361 PAS domain; Region: PAS_9; pfam13426 706587012362 putative active site [active] 706587012363 heme pocket [chemical binding]; other site 706587012364 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706587012365 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706587012366 metal binding site [ion binding]; metal-binding site 706587012367 active site 706587012368 I-site; other site 706587012369 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 706587012370 putative FMN binding site [chemical binding]; other site 706587012371 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 706587012372 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 706587012373 ABC1 family; Region: ABC1; pfam03109 706587012374 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 706587012375 active site 706587012376 ATP binding site [chemical binding]; other site 706587012377 NMT1/THI5 like; Region: NMT1; pfam09084 706587012378 Cache domain; Region: Cache_1; pfam02743 706587012379 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587012380 dimerization interface [polypeptide binding]; other site 706587012381 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 706587012382 cyclase homology domain; Region: CHD; cd07302 706587012383 nucleotidyl binding site; other site 706587012384 metal binding site [ion binding]; metal-binding site 706587012385 dimer interface [polypeptide binding]; other site 706587012386 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587012387 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 706587012388 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 706587012389 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 706587012390 Probable Catalytic site; other site 706587012391 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 706587012392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587012393 AAA domain; Region: AAA_26; pfam13500 706587012394 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 706587012395 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 706587012396 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 706587012397 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 706587012398 NAD(P) binding site [chemical binding]; other site 706587012399 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 706587012400 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 706587012401 dimerization interface [polypeptide binding]; other site 706587012402 ATP binding site [chemical binding]; other site 706587012403 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 706587012404 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 706587012405 HupF/HypC family; Region: HupF_HypC; pfam01455 706587012406 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587012407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587012408 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587012409 Acylphosphatase; Region: Acylphosphatase; pfam00708 706587012410 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 706587012411 HypF finger; Region: zf-HYPF; pfam07503 706587012412 HypF finger; Region: zf-HYPF; pfam07503 706587012413 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 706587012414 anthranilate synthase component I; Provisional; Region: PRK13565 706587012415 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 706587012416 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 706587012417 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 706587012418 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 706587012419 glutamine binding [chemical binding]; other site 706587012420 catalytic triad [active] 706587012421 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 706587012422 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 706587012423 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 706587012424 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 706587012425 active site 706587012426 ribulose/triose binding site [chemical binding]; other site 706587012427 phosphate binding site [ion binding]; other site 706587012428 substrate (anthranilate) binding pocket [chemical binding]; other site 706587012429 product (indole) binding pocket [chemical binding]; other site 706587012430 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 706587012431 active site 706587012432 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 706587012433 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 706587012434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587012435 catalytic residue [active] 706587012436 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 706587012437 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 706587012438 substrate binding site [chemical binding]; other site 706587012439 active site 706587012440 catalytic residues [active] 706587012441 heterodimer interface [polypeptide binding]; other site 706587012442 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 706587012443 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 706587012444 minor groove reading motif; other site 706587012445 helix-hairpin-helix signature motif; other site 706587012446 substrate binding pocket [chemical binding]; other site 706587012447 active site 706587012448 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 706587012449 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 706587012450 active site 706587012451 HIGH motif; other site 706587012452 dimer interface [polypeptide binding]; other site 706587012453 KMSKS motif; other site 706587012454 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587012455 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587012456 TM-ABC transporter signature motif; other site 706587012457 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587012458 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587012459 Walker A/P-loop; other site 706587012460 ATP binding site [chemical binding]; other site 706587012461 Q-loop/lid; other site 706587012462 ABC transporter signature motif; other site 706587012463 Walker B; other site 706587012464 D-loop; other site 706587012465 H-loop/switch region; other site 706587012466 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587012467 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587012468 Walker A/P-loop; other site 706587012469 ATP binding site [chemical binding]; other site 706587012470 Q-loop/lid; other site 706587012471 ABC transporter signature motif; other site 706587012472 Walker B; other site 706587012473 D-loop; other site 706587012474 H-loop/switch region; other site 706587012475 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 706587012476 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 706587012477 Catalytic site [active] 706587012478 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 706587012479 4Fe-4S binding domain; Region: Fer4_5; pfam12801 706587012480 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587012481 Sec63 Brl domain; Region: Sec63; pfam02889 706587012482 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 706587012483 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 706587012484 [4Fe-4S] binding site [ion binding]; other site 706587012485 molybdopterin cofactor binding site; other site 706587012486 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 706587012487 molybdopterin cofactor binding site; other site 706587012488 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 706587012489 HEAT repeats; Region: HEAT_2; pfam13646 706587012490 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 706587012491 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 706587012492 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 706587012493 4Fe-4S binding domain; Region: Fer4; cl02805 706587012494 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 706587012495 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587012496 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587012497 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587012498 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 706587012499 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 706587012500 putative dimer interface [polypeptide binding]; other site 706587012501 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 706587012502 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 706587012503 putative dimer interface [polypeptide binding]; other site 706587012504 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 706587012505 active site 706587012506 catalytic residues [active] 706587012507 metal binding site [ion binding]; metal-binding site 706587012508 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 706587012509 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 706587012510 putative active site [active] 706587012511 substrate binding site [chemical binding]; other site 706587012512 putative cosubstrate binding site; other site 706587012513 catalytic site [active] 706587012514 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 706587012515 substrate binding site [chemical binding]; other site 706587012516 Peptidase family M48; Region: Peptidase_M48; cl12018 706587012517 NusB family; Region: NusB; pfam01029 706587012518 putative RNA binding site [nucleotide binding]; other site 706587012519 16S rRNA methyltransferase B; Provisional; Region: PRK14902 706587012520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587012521 S-adenosylmethionine binding site [chemical binding]; other site 706587012522 Methyltransferase domain; Region: Methyltransf_23; pfam13489 706587012523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587012524 S-adenosylmethionine binding site [chemical binding]; other site 706587012525 lipoyl synthase; Provisional; Region: PRK05481 706587012526 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587012527 FeS/SAM binding site; other site 706587012528 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 706587012529 tartrate dehydrogenase; Region: TTC; TIGR02089 706587012530 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 706587012531 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587012532 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 706587012533 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 706587012534 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 706587012535 inhibitor-cofactor binding pocket; inhibition site 706587012536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587012537 catalytic residue [active] 706587012538 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 706587012539 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587012540 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587012541 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587012542 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706587012543 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 706587012544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587012545 Walker A motif; other site 706587012546 ATP binding site [chemical binding]; other site 706587012547 Walker B motif; other site 706587012548 arginine finger; other site 706587012549 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 706587012550 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 706587012551 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 706587012552 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 706587012553 Response regulator receiver domain; Region: Response_reg; pfam00072 706587012554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587012555 active site 706587012556 phosphorylation site [posttranslational modification] 706587012557 intermolecular recognition site; other site 706587012558 dimerization interface [polypeptide binding]; other site 706587012559 Uncharacterized conserved protein [Function unknown]; Region: COG1751 706587012560 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 706587012561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587012562 Coenzyme A binding pocket [chemical binding]; other site 706587012563 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 706587012564 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 706587012565 active site 706587012566 Zn binding site [ion binding]; other site 706587012567 acetyl-CoA synthetase; Provisional; Region: PRK04319 706587012568 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587012569 acyl-activating enzyme (AAE) consensus motif; other site 706587012570 AMP binding site [chemical binding]; other site 706587012571 active site 706587012572 CoA binding site [chemical binding]; other site 706587012573 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 706587012574 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587012575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587012576 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587012577 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587012578 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587012579 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587012580 PAS domain; Region: PAS_9; pfam13426 706587012581 PAS fold; Region: PAS_4; pfam08448 706587012582 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587012583 putative active site [active] 706587012584 heme pocket [chemical binding]; other site 706587012585 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587012586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587012587 Walker A motif; other site 706587012588 ATP binding site [chemical binding]; other site 706587012589 Walker B motif; other site 706587012590 arginine finger; other site 706587012591 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587012592 Response regulator receiver domain; Region: Response_reg; pfam00072 706587012593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587012594 active site 706587012595 phosphorylation site [posttranslational modification] 706587012596 intermolecular recognition site; other site 706587012597 dimerization interface [polypeptide binding]; other site 706587012598 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 706587012599 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 706587012600 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 706587012601 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 706587012602 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706587012603 active site 706587012604 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 706587012605 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 706587012606 transmembrane helices; other site 706587012607 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 706587012608 dimer interface [polypeptide binding]; other site 706587012609 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 706587012610 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706587012611 active site 706587012612 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 706587012613 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 706587012614 NAD binding site [chemical binding]; other site 706587012615 substrate binding site [chemical binding]; other site 706587012616 active site 706587012617 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 706587012618 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 706587012619 inhibitor-cofactor binding pocket; inhibition site 706587012620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587012621 catalytic residue [active] 706587012622 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 706587012623 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 706587012624 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706587012625 catalytic residue [active] 706587012626 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 706587012627 Transglycosylase; Region: Transgly; pfam00912 706587012628 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 706587012629 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 706587012630 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 706587012631 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 706587012632 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 706587012633 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 706587012634 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 706587012635 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 706587012636 Malic enzyme, N-terminal domain; Region: malic; pfam00390 706587012637 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 706587012638 putative NAD(P) binding site [chemical binding]; other site 706587012639 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 706587012640 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 706587012641 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 706587012642 Soluble P-type ATPase [General function prediction only]; Region: COG4087 706587012643 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587012644 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587012645 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 706587012646 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 706587012647 Soluble P-type ATPase [General function prediction only]; Region: COG4087 706587012648 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 706587012649 phosphate binding site [ion binding]; other site 706587012650 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 706587012651 active site 706587012652 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 706587012653 DNA gyrase subunit A; Validated; Region: PRK05560 706587012654 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 706587012655 CAP-like domain; other site 706587012656 active site 706587012657 primary dimer interface [polypeptide binding]; other site 706587012658 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 706587012659 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 706587012660 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 706587012661 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 706587012662 PAS domain S-box; Region: sensory_box; TIGR00229 706587012663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587012664 putative active site [active] 706587012665 heme pocket [chemical binding]; other site 706587012666 PAS domain; Region: PAS_8; pfam13188 706587012667 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587012668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587012669 dimer interface [polypeptide binding]; other site 706587012670 phosphorylation site [posttranslational modification] 706587012671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587012672 ATP binding site [chemical binding]; other site 706587012673 Mg2+ binding site [ion binding]; other site 706587012674 G-X-G motif; other site 706587012675 Response regulator receiver domain; Region: Response_reg; pfam00072 706587012676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587012677 active site 706587012678 phosphorylation site [posttranslational modification] 706587012679 intermolecular recognition site; other site 706587012680 dimerization interface [polypeptide binding]; other site 706587012681 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 706587012682 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 706587012683 hypothetical protein; Reviewed; Region: PRK09588 706587012684 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 706587012685 ATP binding site [chemical binding]; other site 706587012686 Walker A motif; other site 706587012687 Walker B motif; other site 706587012688 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 706587012689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587012690 non-specific DNA binding site [nucleotide binding]; other site 706587012691 salt bridge; other site 706587012692 sequence-specific DNA binding site [nucleotide binding]; other site 706587012693 Cupin domain; Region: Cupin_2; pfam07883 706587012694 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587012695 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587012696 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587012697 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 706587012698 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587012699 Cysteine-rich domain; Region: CCG; pfam02754 706587012700 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 706587012701 HAMP domain; Region: HAMP; pfam00672 706587012702 dimerization interface [polypeptide binding]; other site 706587012703 PAS domain; Region: PAS_9; pfam13426 706587012704 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587012705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587012706 ATP binding site [chemical binding]; other site 706587012707 Mg2+ binding site [ion binding]; other site 706587012708 G-X-G motif; other site 706587012709 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706587012710 Ligand Binding Site [chemical binding]; other site 706587012711 Predicted transcriptional regulator [Transcription]; Region: COG1959 706587012712 Transcriptional regulator; Region: Rrf2; cl17282 706587012713 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 706587012714 Chain length determinant protein; Region: Wzz; cl15801 706587012715 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 706587012716 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 706587012717 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 706587012718 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 706587012719 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 706587012720 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706587012721 Ligand Binding Site [chemical binding]; other site 706587012722 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 706587012723 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 706587012724 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587012725 dimerization interface [polypeptide binding]; other site 706587012726 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706587012727 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706587012728 dimer interface [polypeptide binding]; other site 706587012729 putative CheW interface [polypeptide binding]; other site 706587012730 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 706587012731 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 706587012732 CPxP motif; other site 706587012733 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 706587012734 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 706587012735 ATP binding site [chemical binding]; other site 706587012736 substrate binding site [chemical binding]; other site 706587012737 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706587012738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706587012739 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 706587012740 dimerization interface [polypeptide binding]; other site 706587012741 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 706587012742 CGGC domain; Region: CGGC; cl02356 706587012743 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 706587012744 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587012745 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587012746 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587012747 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587012748 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587012749 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587012750 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587012751 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587012752 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587012753 TM-ABC transporter signature motif; other site 706587012754 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587012755 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587012756 TM-ABC transporter signature motif; other site 706587012757 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587012758 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587012759 Walker A/P-loop; other site 706587012760 ATP binding site [chemical binding]; other site 706587012761 Q-loop/lid; other site 706587012762 ABC transporter signature motif; other site 706587012763 Walker B; other site 706587012764 D-loop; other site 706587012765 H-loop/switch region; other site 706587012766 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587012767 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587012768 Walker A/P-loop; other site 706587012769 ATP binding site [chemical binding]; other site 706587012770 Q-loop/lid; other site 706587012771 ABC transporter signature motif; other site 706587012772 Walker B; other site 706587012773 D-loop; other site 706587012774 H-loop/switch region; other site 706587012775 Restriction endonuclease; Region: Mrr_cat; pfam04471 706587012776 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 706587012777 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 706587012778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587012779 putative substrate translocation pore; other site 706587012780 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 706587012781 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 706587012782 active site 706587012783 NTP binding site [chemical binding]; other site 706587012784 metal binding triad [ion binding]; metal-binding site 706587012785 antibiotic binding site [chemical binding]; other site 706587012786 Uncharacterized conserved protein [Function unknown]; Region: COG2361 706587012787 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 706587012788 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 706587012789 putative active site [active] 706587012790 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 706587012791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 706587012792 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 706587012793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587012794 Coenzyme A binding pocket [chemical binding]; other site 706587012795 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 706587012796 Ligand binding site; other site 706587012797 Putative Catalytic site; other site 706587012798 DXD motif; other site 706587012799 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 706587012800 putative active site pocket [active] 706587012801 cleavage site 706587012802 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 706587012803 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 706587012804 NAD(P) binding site [chemical binding]; other site 706587012805 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 706587012806 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 706587012807 DNA interaction; other site 706587012808 Metal-binding active site; metal-binding site 706587012809 SynChlorMet cassette radical SAM/SPASM protein ScmF; Region: SCM_rSAM_ScmF; TIGR04251 706587012810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587012811 FeS/SAM binding site; other site 706587012812 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 706587012813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587012814 Walker A motif; other site 706587012815 ATP binding site [chemical binding]; other site 706587012816 Walker B motif; other site 706587012817 arginine finger; other site 706587012818 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 706587012819 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 706587012820 isocitrate dehydrogenase; Validated; Region: PRK07362 706587012821 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 706587012822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587012823 Phage terminase small subunit; Region: Phage_terminase; pfam10668 706587012824 Phage terminase small subunit; Region: Phage_terminase; pfam10668 706587012825 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 706587012826 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 706587012827 Cysteine-rich domain; Region: CCG; pfam02754 706587012828 Cysteine-rich domain; Region: CCG; pfam02754 706587012829 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 706587012830 4Fe-4S binding domain; Region: Fer4; pfam00037 706587012831 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 706587012832 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 706587012833 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587012834 4Fe-4S binding domain; Region: Fer4; pfam00037 706587012835 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587012836 4Fe-4S binding domain; Region: Fer4; pfam00037 706587012837 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 706587012838 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587012839 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587012840 Cysteine-rich domain; Region: CCG; pfam02754 706587012841 Cysteine-rich domain; Region: CCG; pfam02754 706587012842 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 706587012843 4Fe-4S binding domain; Region: Fer4; cl02805 706587012844 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587012845 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 706587012846 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587012847 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 706587012848 Isochorismatase family; Region: Isochorismatase; pfam00857 706587012849 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 706587012850 catalytic triad [active] 706587012851 dimer interface [polypeptide binding]; other site 706587012852 conserved cis-peptide bond; other site 706587012853 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 706587012854 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 706587012855 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 706587012856 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 706587012857 active site 706587012858 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 706587012859 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 706587012860 metal binding site 2 [ion binding]; metal-binding site 706587012861 putative DNA binding helix; other site 706587012862 metal binding site 1 [ion binding]; metal-binding site 706587012863 dimer interface [polypeptide binding]; other site 706587012864 structural Zn2+ binding site [ion binding]; other site 706587012865 Rubrerythrin [Energy production and conversion]; Region: COG1592 706587012866 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 706587012867 binuclear metal center [ion binding]; other site 706587012868 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 706587012869 iron binding site [ion binding]; other site 706587012870 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 706587012871 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 706587012872 non-heme iron binding site [ion binding]; other site 706587012873 dimer interface [polypeptide binding]; other site 706587012874 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 706587012875 non-heme iron binding site [ion binding]; other site 706587012876 dimer interface [polypeptide binding]; other site 706587012877 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 706587012878 Rubredoxin; Region: Rubredoxin; pfam00301 706587012879 iron binding site [ion binding]; other site 706587012880 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 706587012881 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 706587012882 catalytic residues [active] 706587012883 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 706587012884 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 706587012885 dimer interface [polypeptide binding]; other site 706587012886 catalytic triad [active] 706587012887 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 706587012888 Rubredoxin [Energy production and conversion]; Region: COG1773 706587012889 DsrE/DsrF-like family; Region: DrsE; pfam02635 706587012890 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 706587012891 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706587012892 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 706587012893 Rubredoxin; Region: Rubredoxin; pfam00301 706587012894 iron binding site [ion binding]; other site 706587012895 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 706587012896 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587012897 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 706587012898 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 706587012899 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 706587012900 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 706587012901 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 706587012902 dimer interface [polypeptide binding]; other site 706587012903 catalytic triad [active] 706587012904 peroxidatic and resolving cysteines [active] 706587012905 Ion channel; Region: Ion_trans_2; pfam07885 706587012906 TrkA-N domain; Region: TrkA_N; pfam02254 706587012907 Protein of unknown function (DUF1012); Region: DUF1012; pfam06241 706587012908 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 706587012909 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 706587012910 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 706587012911 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 706587012912 metal-binding site [ion binding] 706587012913 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 706587012914 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 706587012915 metal-binding site [ion binding] 706587012916 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 706587012917 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 706587012918 metal-binding site [ion binding] 706587012919 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 706587012920 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 706587012921 Methyltransferase domain; Region: Methyltransf_26; pfam13659 706587012922 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 706587012923 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 706587012924 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 706587012925 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 706587012926 Chain length determinant protein; Region: Wzz; pfam02706 706587012927 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 706587012928 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587012929 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 706587012930 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 706587012931 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 706587012932 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 706587012933 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 706587012934 putative trimer interface [polypeptide binding]; other site 706587012935 putative active site [active] 706587012936 putative substrate binding site [chemical binding]; other site 706587012937 putative CoA binding site [chemical binding]; other site 706587012938 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 706587012939 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 706587012940 inhibitor-cofactor binding pocket; inhibition site 706587012941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587012942 catalytic residue [active] 706587012943 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 706587012944 active site 706587012945 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 706587012946 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 706587012947 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 706587012948 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 706587012949 O-Antigen ligase; Region: Wzy_C; pfam04932 706587012950 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 706587012951 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587012952 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 706587012953 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 706587012954 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706587012955 catalytic residue [active] 706587012956 putative glycosyl transferase; Provisional; Region: PRK10307 706587012957 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 706587012958 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 706587012959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 706587012960 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 706587012961 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706587012962 ABC-ATPase subunit interface; other site 706587012963 dimer interface [polypeptide binding]; other site 706587012964 putative PBP binding regions; other site 706587012965 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 706587012966 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 706587012967 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 706587012968 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 706587012969 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 706587012970 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 706587012971 metal binding site [ion binding]; metal-binding site 706587012972 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587012973 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587012974 putative active site [active] 706587012975 heme pocket [chemical binding]; other site 706587012976 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587012977 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587012978 putative active site [active] 706587012979 heme pocket [chemical binding]; other site 706587012980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587012981 putative active site [active] 706587012982 heme pocket [chemical binding]; other site 706587012983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587012984 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 706587012985 Walker A motif; other site 706587012986 ATP binding site [chemical binding]; other site 706587012987 Walker B motif; other site 706587012988 arginine finger; other site 706587012989 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 706587012990 tetramer interface [polypeptide binding]; other site 706587012991 dimer interface [polypeptide binding]; other site 706587012992 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 706587012993 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 706587012994 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 706587012995 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 706587012996 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587012997 FeS/SAM binding site; other site 706587012998 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 706587012999 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 706587013000 Cache domain; Region: Cache_1; pfam02743 706587013001 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587013002 dimerization interface [polypeptide binding]; other site 706587013003 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 706587013004 cyclase homology domain; Region: CHD; cd07302 706587013005 nucleotidyl binding site; other site 706587013006 metal binding site [ion binding]; metal-binding site 706587013007 dimer interface [polypeptide binding]; other site 706587013008 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587013009 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587013010 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587013011 TM-ABC transporter signature motif; other site 706587013012 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587013013 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587013014 TM-ABC transporter signature motif; other site 706587013015 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587013016 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587013017 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587013018 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587013019 Walker A/P-loop; other site 706587013020 ATP binding site [chemical binding]; other site 706587013021 Q-loop/lid; other site 706587013022 ABC transporter signature motif; other site 706587013023 Walker B; other site 706587013024 D-loop; other site 706587013025 H-loop/switch region; other site 706587013026 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587013027 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587013028 Walker A/P-loop; other site 706587013029 ATP binding site [chemical binding]; other site 706587013030 Q-loop/lid; other site 706587013031 ABC transporter signature motif; other site 706587013032 Walker B; other site 706587013033 D-loop; other site 706587013034 H-loop/switch region; other site 706587013035 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 706587013036 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587013037 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 706587013038 acyl-activating enzyme (AAE) consensus motif; other site 706587013039 acyl-activating enzyme (AAE) consensus motif; other site 706587013040 putative AMP binding site [chemical binding]; other site 706587013041 putative active site [active] 706587013042 putative CoA binding site [chemical binding]; other site 706587013043 asparagine synthetase AsnA; Provisional; Region: PRK05425 706587013044 motif 1; other site 706587013045 dimer interface [polypeptide binding]; other site 706587013046 active site 706587013047 motif 2; other site 706587013048 motif 3; other site 706587013049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587013050 dimer interface [polypeptide binding]; other site 706587013051 phosphorylation site [posttranslational modification] 706587013052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587013053 ATP binding site [chemical binding]; other site 706587013054 Mg2+ binding site [ion binding]; other site 706587013055 G-X-G motif; other site 706587013056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587013057 active site 706587013058 phosphorylation site [posttranslational modification] 706587013059 intermolecular recognition site; other site 706587013060 dimerization interface [polypeptide binding]; other site 706587013061 Major royal jelly protein; Region: MRJP; pfam03022 706587013062 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 706587013063 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 706587013064 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 706587013065 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 706587013066 Metal-binding active site; metal-binding site 706587013067 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 706587013068 active site clefts [active] 706587013069 zinc binding site [ion binding]; other site 706587013070 dimer interface [polypeptide binding]; other site 706587013071 Response regulator receiver domain; Region: Response_reg; pfam00072 706587013072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587013073 active site 706587013074 phosphorylation site [posttranslational modification] 706587013075 intermolecular recognition site; other site 706587013076 dimerization interface [polypeptide binding]; other site 706587013077 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587013078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587013079 dimer interface [polypeptide binding]; other site 706587013080 phosphorylation site [posttranslational modification] 706587013081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587013082 ATP binding site [chemical binding]; other site 706587013083 Mg2+ binding site [ion binding]; other site 706587013084 G-X-G motif; other site 706587013085 Response regulator receiver domain; Region: Response_reg; pfam00072 706587013086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587013087 active site 706587013088 phosphorylation site [posttranslational modification] 706587013089 intermolecular recognition site; other site 706587013090 dimerization interface [polypeptide binding]; other site 706587013091 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 706587013092 Response regulator receiver domain; Region: Response_reg; pfam00072 706587013093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587013094 active site 706587013095 phosphorylation site [posttranslational modification] 706587013096 intermolecular recognition site; other site 706587013097 dimerization interface [polypeptide binding]; other site 706587013098 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 706587013099 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 706587013100 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 706587013101 transmembrane helices; other site 706587013102 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 706587013103 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 706587013104 transmembrane helices; other site 706587013105 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 706587013106 Response regulator receiver domain; Region: Response_reg; pfam00072 706587013107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587013108 active site 706587013109 phosphorylation site [posttranslational modification] 706587013110 intermolecular recognition site; other site 706587013111 dimerization interface [polypeptide binding]; other site 706587013112 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 706587013113 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587013114 PAS domain; Region: PAS_9; pfam13426 706587013115 putative active site [active] 706587013116 heme pocket [chemical binding]; other site 706587013117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587013118 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587013119 Walker A motif; other site 706587013120 ATP binding site [chemical binding]; other site 706587013121 Walker B motif; other site 706587013122 arginine finger; other site 706587013123 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587013124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 706587013125 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 706587013126 Predicted metal-binding protein [Function unknown]; Region: COG5561 706587013127 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 706587013128 active site 706587013129 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 706587013130 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 706587013131 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 706587013132 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 706587013133 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 706587013134 Response regulator receiver domain; Region: Response_reg; pfam00072 706587013135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587013136 active site 706587013137 phosphorylation site [posttranslational modification] 706587013138 intermolecular recognition site; other site 706587013139 dimerization interface [polypeptide binding]; other site 706587013140 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 706587013141 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 706587013142 DctM-like transporters; Region: DctM; pfam06808 706587013143 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 706587013144 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 706587013145 GAF domain; Region: GAF; pfam01590 706587013146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587013147 Walker A motif; other site 706587013148 ATP binding site [chemical binding]; other site 706587013149 Walker B motif; other site 706587013150 arginine finger; other site 706587013151 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587013152 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 706587013153 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 706587013154 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 706587013155 dimer interface [polypeptide binding]; other site 706587013156 active site residues [active] 706587013157 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 706587013158 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 706587013159 Fe-S cluster binding site [ion binding]; other site 706587013160 active site 706587013161 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 706587013162 Flavoprotein; Region: Flavoprotein; pfam02441 706587013163 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 706587013164 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 706587013165 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 706587013166 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 706587013167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706587013168 DNA-binding site [nucleotide binding]; DNA binding site 706587013169 UTRA domain; Region: UTRA; pfam07702 706587013170 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 706587013171 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 706587013172 active site 706587013173 glycine/sarcosine/betaine reductase complex protein A; Reviewed; Region: PRK13265 706587013174 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 706587013175 catalytic residues [active] 706587013176 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 706587013177 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706587013178 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587013179 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 706587013180 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 706587013181 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 706587013182 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 706587013183 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 706587013184 transmembrane helices; other site 706587013185 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587013186 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587013187 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013188 PAS domain S-box; Region: sensory_box; TIGR00229 706587013189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587013190 putative active site [active] 706587013191 heme pocket [chemical binding]; other site 706587013192 PAS domain S-box; Region: sensory_box; TIGR00229 706587013193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587013194 putative active site [active] 706587013195 heme pocket [chemical binding]; other site 706587013196 PAS fold; Region: PAS_4; pfam08448 706587013197 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 706587013198 putative active site [active] 706587013199 heme pocket [chemical binding]; other site 706587013200 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 706587013201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587013202 Walker A motif; other site 706587013203 ATP binding site [chemical binding]; other site 706587013204 Walker B motif; other site 706587013205 arginine finger; other site 706587013206 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 706587013207 propionate/acetate kinase; Provisional; Region: PRK12379 706587013208 phosphate acetyltransferase; Reviewed; Region: PRK05632 706587013209 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587013210 DRTGG domain; Region: DRTGG; pfam07085 706587013211 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 706587013212 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 706587013213 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 706587013214 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 706587013215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587013216 Coenzyme A binding pocket [chemical binding]; other site 706587013217 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 706587013218 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 706587013219 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 706587013220 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587013221 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 706587013222 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 706587013223 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 706587013224 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 706587013225 conserved cys residue [active] 706587013226 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587013227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587013228 TPR motif; other site 706587013229 binding surface 706587013230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587013231 TPR motif; other site 706587013232 binding surface 706587013233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587013234 binding surface 706587013235 TPR motif; other site 706587013236 TPR repeat; Region: TPR_11; pfam13414 706587013237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587013238 binding surface 706587013239 TPR motif; other site 706587013240 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587013241 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 706587013242 catalytic motif [active] 706587013243 Catalytic residue [active] 706587013244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587013245 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587013246 excinuclease ABC subunit B; Provisional; Region: PRK05298 706587013247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706587013248 ATP binding site [chemical binding]; other site 706587013249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706587013250 nucleotide binding region [chemical binding]; other site 706587013251 ATP-binding site [chemical binding]; other site 706587013252 Ultra-violet resistance protein B; Region: UvrB; pfam12344 706587013253 UvrB/uvrC motif; Region: UVR; pfam02151 706587013254 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 706587013255 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 706587013256 active site 706587013257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587013258 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587013259 recombination factor protein RarA; Reviewed; Region: PRK13342 706587013260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587013261 Walker A motif; other site 706587013262 ATP binding site [chemical binding]; other site 706587013263 Walker B motif; other site 706587013264 arginine finger; other site 706587013265 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 706587013266 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 706587013267 ATP-NAD kinase; Region: NAD_kinase; pfam01513 706587013268 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 706587013269 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 706587013270 Walker A/P-loop; other site 706587013271 ATP binding site [chemical binding]; other site 706587013272 Q-loop/lid; other site 706587013273 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 706587013274 ABC transporter signature motif; other site 706587013275 Walker B; other site 706587013276 D-loop; other site 706587013277 H-loop/switch region; other site 706587013278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587013279 Coenzyme A binding pocket [chemical binding]; other site 706587013280 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 706587013281 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 706587013282 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 706587013283 Beta-lactamase; Region: Beta-lactamase; pfam00144 706587013284 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 706587013285 active site 706587013286 NTP binding site [chemical binding]; other site 706587013287 metal binding triad [ion binding]; metal-binding site 706587013288 antibiotic binding site [chemical binding]; other site 706587013289 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 706587013290 active site 706587013291 NTP binding site [chemical binding]; other site 706587013292 metal binding triad [ion binding]; metal-binding site 706587013293 antibiotic binding site [chemical binding]; other site 706587013294 Protein of unknown function DUF86; Region: DUF86; cl01031 706587013295 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 706587013296 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 706587013297 endonuclease III; Region: ENDO3c; smart00478 706587013298 minor groove reading motif; other site 706587013299 helix-hairpin-helix signature motif; other site 706587013300 substrate binding pocket [chemical binding]; other site 706587013301 active site 706587013302 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 706587013303 FOG: CBS domain [General function prediction only]; Region: COG0517 706587013304 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 706587013305 Response regulator receiver domain; Region: Response_reg; pfam00072 706587013306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587013307 active site 706587013308 phosphorylation site [posttranslational modification] 706587013309 intermolecular recognition site; other site 706587013310 dimerization interface [polypeptide binding]; other site 706587013311 Response regulator receiver domain; Region: Response_reg; pfam00072 706587013312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587013313 active site 706587013314 phosphorylation site [posttranslational modification] 706587013315 intermolecular recognition site; other site 706587013316 dimerization interface [polypeptide binding]; other site 706587013317 Homeodomain-like domain; Region: HTH_23; pfam13384 706587013318 Winged helix-turn helix; Region: HTH_29; pfam13551 706587013319 Homeodomain-like domain; Region: HTH_32; pfam13565 706587013320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587013321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587013322 dimer interface [polypeptide binding]; other site 706587013323 phosphorylation site [posttranslational modification] 706587013324 Response regulator receiver domain; Region: Response_reg; pfam00072 706587013325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587013326 active site 706587013327 phosphorylation site [posttranslational modification] 706587013328 intermolecular recognition site; other site 706587013329 dimerization interface [polypeptide binding]; other site 706587013330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587013331 dimer interface [polypeptide binding]; other site 706587013332 phosphorylation site [posttranslational modification] 706587013333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587013334 ATP binding site [chemical binding]; other site 706587013335 Mg2+ binding site [ion binding]; other site 706587013336 G-X-G motif; other site 706587013337 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 706587013338 dimer interface [polypeptide binding]; other site 706587013339 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 706587013340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587013341 Walker A motif; other site 706587013342 ATP binding site [chemical binding]; other site 706587013343 Walker B motif; other site 706587013344 arginine finger; other site 706587013345 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 706587013346 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 706587013347 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382 706587013348 UbiA prenyltransferase family; Region: UbiA; pfam01040 706587013349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587013350 S-adenosylmethionine binding site [chemical binding]; other site 706587013351 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 706587013352 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 706587013353 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 706587013354 putative active site [active] 706587013355 catalytic residue [active] 706587013356 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 706587013357 active site 706587013358 dimer interface [polypeptide binding]; other site 706587013359 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 706587013360 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 706587013361 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 706587013362 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 706587013363 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 706587013364 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 706587013365 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 706587013366 active site 706587013367 substrate binding site [chemical binding]; other site 706587013368 metal binding site [ion binding]; metal-binding site 706587013369 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 706587013370 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 706587013371 Leucine carboxyl methyltransferase; Region: LCM; cl01306 706587013372 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587013373 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587013374 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587013375 putative active site [active] 706587013376 heme pocket [chemical binding]; other site 706587013377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587013378 dimer interface [polypeptide binding]; other site 706587013379 phosphorylation site [posttranslational modification] 706587013380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587013381 ATP binding site [chemical binding]; other site 706587013382 Mg2+ binding site [ion binding]; other site 706587013383 G-X-G motif; other site 706587013384 Response regulator receiver domain; Region: Response_reg; pfam00072 706587013385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587013386 active site 706587013387 phosphorylation site [posttranslational modification] 706587013388 intermolecular recognition site; other site 706587013389 dimerization interface [polypeptide binding]; other site 706587013390 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 706587013391 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587013392 dimerization interface [polypeptide binding]; other site 706587013393 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 706587013394 cyclase homology domain; Region: CHD; cd07302 706587013395 nucleotidyl binding site; other site 706587013396 metal binding site [ion binding]; metal-binding site 706587013397 dimer interface [polypeptide binding]; other site 706587013398 NosL; Region: NosL; cl01769 706587013399 NosL; Region: NosL; cl01769 706587013400 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 706587013401 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 706587013402 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 706587013403 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587013404 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 706587013405 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587013406 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587013407 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587013408 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 706587013409 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 706587013410 Walker A/P-loop; other site 706587013411 ATP binding site [chemical binding]; other site 706587013412 Q-loop/lid; other site 706587013413 ABC transporter signature motif; other site 706587013414 Walker B; other site 706587013415 D-loop; other site 706587013416 H-loop/switch region; other site 706587013417 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587013418 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 706587013419 FtsX-like permease family; Region: FtsX; pfam02687 706587013420 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 706587013421 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 706587013422 metal-binding site [ion binding] 706587013423 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 706587013424 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013425 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587013426 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013427 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 706587013428 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 706587013429 Ligand Binding Site [chemical binding]; other site 706587013430 hypothetical protein; Provisional; Region: PRK04194 706587013431 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 706587013432 MoaE interaction surface [polypeptide binding]; other site 706587013433 thiocarboxylated glycine; other site 706587013434 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 706587013435 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 706587013436 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 706587013437 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 706587013438 Ligand Binding Site [chemical binding]; other site 706587013439 TilS substrate C-terminal domain; Region: TilS_C; smart00977 706587013440 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 706587013441 active site residue [active] 706587013442 Hemerythrin-like domain; Region: Hr-like; cd12108 706587013443 Fe binding site [ion binding]; other site 706587013444 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 706587013445 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 706587013446 NAD binding site [chemical binding]; other site 706587013447 homotetramer interface [polypeptide binding]; other site 706587013448 homodimer interface [polypeptide binding]; other site 706587013449 active site 706587013450 substrate binding site [chemical binding]; other site 706587013451 primosome assembly protein PriA; Validated; Region: PRK05580 706587013452 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 706587013453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587013454 Coenzyme A binding pocket [chemical binding]; other site 706587013455 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706587013456 dimerization interface [polypeptide binding]; other site 706587013457 putative DNA binding site [nucleotide binding]; other site 706587013458 putative Zn2+ binding site [ion binding]; other site 706587013459 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 706587013460 active site 706587013461 NTP binding site [chemical binding]; other site 706587013462 metal binding triad [ion binding]; metal-binding site 706587013463 antibiotic binding site [chemical binding]; other site 706587013464 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 706587013465 putative active site [active] 706587013466 putative catalytic site [active] 706587013467 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06035 706587013468 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 706587013469 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 706587013470 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 706587013471 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587013472 substrate binding site [chemical binding]; other site 706587013473 oxyanion hole (OAH) forming residues; other site 706587013474 trimer interface [polypeptide binding]; other site 706587013475 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 706587013476 FMN binding site [chemical binding]; other site 706587013477 dimer interface [polypeptide binding]; other site 706587013478 NHL repeat; Region: NHL; pfam01436 706587013479 NHL repeat; Region: NHL; pfam01436 706587013480 NHL repeat; Region: NHL; pfam01436 706587013481 NHL repeat; Region: NHL; pfam01436 706587013482 FMN-binding domain; Region: FMN_bind; cl01081 706587013483 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 706587013484 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587013485 CoB--CoM heterodisulfide reductase, subunit C; Region: CoB_CoM_SS_C; TIGR03290 706587013486 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706587013487 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 706587013488 FAD binding domain; Region: FAD_binding_2; pfam00890 706587013489 L-aspartate oxidase; Provisional; Region: PRK06175 706587013490 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 706587013491 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 706587013492 4Fe-4S binding domain; Region: Fer4; pfam00037 706587013493 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 706587013494 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 706587013495 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 706587013496 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 706587013497 molybdopterin cofactor binding site; other site 706587013498 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 706587013499 molybdopterin cofactor binding site; other site 706587013500 PilZ domain; Region: PilZ; pfam07238 706587013501 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 706587013502 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 706587013503 dimer interface [polypeptide binding]; other site 706587013504 ADP-ribose binding site [chemical binding]; other site 706587013505 active site 706587013506 nudix motif; other site 706587013507 metal binding site [ion binding]; metal-binding site 706587013508 TPR repeat; Region: TPR_11; pfam13414 706587013509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587013510 binding surface 706587013511 TPR motif; other site 706587013512 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587013513 PilZ domain; Region: PilZ; cl01260 706587013514 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 706587013515 Catalytic domain of Protein Kinases; Region: PKc; cd00180 706587013516 active site 706587013517 ATP binding site [chemical binding]; other site 706587013518 substrate binding site [chemical binding]; other site 706587013519 activation loop (A-loop); other site 706587013520 phosphodiesterase; Provisional; Region: PRK12704 706587013521 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 706587013522 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587013523 Zn2+ binding site [ion binding]; other site 706587013524 Mg2+ binding site [ion binding]; other site 706587013525 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 706587013526 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 706587013527 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 706587013528 FMN binding site [chemical binding]; other site 706587013529 active site 706587013530 catalytic residues [active] 706587013531 substrate binding site [chemical binding]; other site 706587013532 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 706587013533 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 706587013534 Substrate binding site; other site 706587013535 Mg++ binding site; other site 706587013536 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 706587013537 active site 706587013538 substrate binding site [chemical binding]; other site 706587013539 CoA binding site [chemical binding]; other site 706587013540 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 706587013541 TPR repeat; Region: TPR_11; pfam13414 706587013542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587013543 binding surface 706587013544 TPR motif; other site 706587013545 TPR repeat; Region: TPR_11; pfam13414 706587013546 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 706587013547 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 706587013548 Transposase IS200 like; Region: Y1_Tnp; pfam01797 706587013549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587013550 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587013551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587013552 active site 706587013553 phosphorylation site [posttranslational modification] 706587013554 intermolecular recognition site; other site 706587013555 dimerization interface [polypeptide binding]; other site 706587013556 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 706587013557 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587013558 acyl-activating enzyme (AAE) consensus motif; other site 706587013559 AMP binding site [chemical binding]; other site 706587013560 active site 706587013561 CoA binding site [chemical binding]; other site 706587013562 DctM-like transporters; Region: DctM; pfam06808 706587013563 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 706587013564 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 706587013565 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 706587013566 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 706587013567 PAS domain S-box; Region: sensory_box; TIGR00229 706587013568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587013569 putative active site [active] 706587013570 heme pocket [chemical binding]; other site 706587013571 PAS fold; Region: PAS_4; pfam08448 706587013572 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587013573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587013574 Walker A motif; other site 706587013575 ATP binding site [chemical binding]; other site 706587013576 Walker B motif; other site 706587013577 arginine finger; other site 706587013578 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587013579 helicase Cas3; Provisional; Region: PRK09694 706587013580 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 706587013581 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 706587013582 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 706587013583 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 706587013584 CT1975-like protein; Region: Cas_CT1975; pfam09344 706587013585 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 706587013586 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 706587013587 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 706587013588 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 706587013589 putative ssRNA endonuclease; Provisional; Region: PRK11558 706587013590 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 706587013591 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706587013592 DNA binding residues [nucleotide binding] 706587013593 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 706587013594 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 706587013595 active site 706587013596 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 706587013597 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 706587013598 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 706587013599 O-Antigen ligase; Region: Wzy_C; pfam04932 706587013600 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587013601 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 706587013602 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 706587013603 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 706587013604 trimer interface [polypeptide binding]; other site 706587013605 active site 706587013606 substrate binding site [chemical binding]; other site 706587013607 CoA binding site [chemical binding]; other site 706587013608 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 706587013609 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 706587013610 Ligand binding site; other site 706587013611 Chain length determinant protein; Region: Wzz; cl15801 706587013612 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 706587013613 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 706587013614 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 706587013615 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587013616 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 706587013617 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587013618 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587013619 AMP binding site [chemical binding]; other site 706587013620 active site 706587013621 acyl-activating enzyme (AAE) consensus motif; other site 706587013622 acyl-activating enzyme (AAE) consensus motif; other site 706587013623 CoA binding site [chemical binding]; other site 706587013624 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 706587013625 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 706587013626 Ligand binding site; other site 706587013627 Uncharacterized conserved protein [Function unknown]; Region: COG1434 706587013628 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 706587013629 putative active site [active] 706587013630 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587013631 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 706587013632 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 706587013633 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 706587013634 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 706587013635 GAF domain; Region: GAF_2; pfam13185 706587013636 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 706587013637 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706587013638 GAF domain; Region: GAF_3; pfam13492 706587013639 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 706587013640 dimer interaction site [polypeptide binding]; other site 706587013641 substrate-binding tunnel; other site 706587013642 active site 706587013643 catalytic site [active] 706587013644 substrate binding site [chemical binding]; other site 706587013645 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587013646 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587013647 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013648 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013649 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587013650 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587013651 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587013652 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013653 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013654 Ankyrin repeat; Region: Ank; pfam00023 706587013655 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587013656 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013657 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587013658 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013659 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587013660 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587013661 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013662 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587013663 PAS domain; Region: PAS_9; pfam13426 706587013664 putative active site [active] 706587013665 heme pocket [chemical binding]; other site 706587013666 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 706587013667 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706587013668 DNA binding residues [nucleotide binding] 706587013669 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 706587013670 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 706587013671 conserved cys residue [active] 706587013672 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 706587013673 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 706587013674 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 706587013675 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 706587013676 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 706587013677 SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249 706587013678 glycogen branching enzyme; Provisional; Region: PRK05402 706587013679 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 706587013680 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 706587013681 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 706587013682 active site 706587013683 catalytic site [active] 706587013684 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 706587013685 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 706587013686 Putative zinc ribbon domain; Region: DUF164; pfam02591 706587013687 Uncharacterized conserved protein [Function unknown]; Region: COG0327 706587013688 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 706587013689 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587013690 Zn2+ binding site [ion binding]; other site 706587013691 Mg2+ binding site [ion binding]; other site 706587013692 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 706587013693 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 706587013694 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 706587013695 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013696 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587013697 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013698 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587013699 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013700 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587013701 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587013702 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587013703 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013704 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013705 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587013706 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587013707 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013708 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587013709 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 706587013710 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 706587013711 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG2881 706587013712 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 706587013713 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 706587013714 Ligand Binding Site [chemical binding]; other site 706587013715 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 706587013716 AMMECR1; Region: AMMECR1; pfam01871 706587013717 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 706587013718 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 706587013719 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 706587013720 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 706587013721 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 706587013722 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 706587013723 active site 706587013724 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 706587013725 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 706587013726 tandem repeat interface [polypeptide binding]; other site 706587013727 oligomer interface [polypeptide binding]; other site 706587013728 active site residues [active] 706587013729 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 706587013730 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 706587013731 Walker A/P-loop; other site 706587013732 ATP binding site [chemical binding]; other site 706587013733 Q-loop/lid; other site 706587013734 ABC transporter signature motif; other site 706587013735 Walker B; other site 706587013736 D-loop; other site 706587013737 H-loop/switch region; other site 706587013738 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 706587013739 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 706587013740 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 706587013741 active site 706587013742 hypothetical protein; Provisional; Region: PRK06361 706587013743 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 706587013744 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449 706587013745 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 706587013746 active site 706587013747 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 706587013748 dimer interface [polypeptide binding]; other site 706587013749 active site 706587013750 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 706587013751 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 706587013752 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 706587013753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587013754 FeS/SAM binding site; other site 706587013755 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 706587013756 MutS domain I; Region: MutS_I; pfam01624 706587013757 MutS domain II; Region: MutS_II; pfam05188 706587013758 MutS domain III; Region: MutS_III; pfam05192 706587013759 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 706587013760 Walker A/P-loop; other site 706587013761 ATP binding site [chemical binding]; other site 706587013762 Q-loop/lid; other site 706587013763 ABC transporter signature motif; other site 706587013764 Walker B; other site 706587013765 D-loop; other site 706587013766 H-loop/switch region; other site 706587013767 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 706587013768 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 706587013769 active site 706587013770 Int/Topo IB signature motif; other site 706587013771 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 706587013772 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 706587013773 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 706587013774 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 706587013775 substrate-cofactor binding pocket; other site 706587013776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587013777 catalytic residue [active] 706587013778 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 706587013779 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 706587013780 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 706587013781 IHF dimer interface [polypeptide binding]; other site 706587013782 IHF - DNA interface [nucleotide binding]; other site 706587013783 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 706587013784 Methylamine utilisation protein MauE; Region: MauE; pfam07291 706587013785 GAF domain; Region: GAF; cl17456 706587013786 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 706587013787 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587013788 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 706587013789 acyl-activating enzyme (AAE) consensus motif; other site 706587013790 acyl-activating enzyme (AAE) consensus motif; other site 706587013791 putative AMP binding site [chemical binding]; other site 706587013792 putative active site [active] 706587013793 putative CoA binding site [chemical binding]; other site 706587013794 PAS domain; Region: PAS; smart00091 706587013795 PAS fold; Region: PAS; pfam00989 706587013796 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 706587013797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587013798 Walker A motif; other site 706587013799 ATP binding site [chemical binding]; other site 706587013800 Walker B motif; other site 706587013801 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587013802 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 706587013803 classical (c) SDRs; Region: SDR_c; cd05233 706587013804 NAD(P) binding site [chemical binding]; other site 706587013805 active site 706587013806 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587013807 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587013808 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587013809 TM-ABC transporter signature motif; other site 706587013810 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587013811 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587013812 TM-ABC transporter signature motif; other site 706587013813 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587013814 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587013815 Walker A/P-loop; other site 706587013816 ATP binding site [chemical binding]; other site 706587013817 Q-loop/lid; other site 706587013818 ABC transporter signature motif; other site 706587013819 Walker B; other site 706587013820 D-loop; other site 706587013821 H-loop/switch region; other site 706587013822 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587013823 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587013824 Walker A/P-loop; other site 706587013825 ATP binding site [chemical binding]; other site 706587013826 Q-loop/lid; other site 706587013827 ABC transporter signature motif; other site 706587013828 Walker B; other site 706587013829 D-loop; other site 706587013830 H-loop/switch region; other site 706587013831 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 706587013832 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 706587013833 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 706587013834 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 706587013835 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 706587013836 putative ligand binding site [chemical binding]; other site 706587013837 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587013838 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587013839 TM-ABC transporter signature motif; other site 706587013840 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706587013841 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 706587013842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 706587013843 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 706587013844 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 706587013845 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 706587013846 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 706587013847 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 706587013848 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 706587013849 ATP binding site [chemical binding]; other site 706587013850 substrate interface [chemical binding]; other site 706587013851 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 706587013852 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 706587013853 Substrate binding site; other site 706587013854 Mg++ binding site; other site 706587013855 metal-binding site 706587013856 Mg++ binding site; other site 706587013857 metal-binding site 706587013858 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 706587013859 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 706587013860 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 706587013861 IHF dimer interface [polypeptide binding]; other site 706587013862 IHF - DNA interface [nucleotide binding]; other site 706587013863 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 706587013864 IHF - DNA interface [nucleotide binding]; other site 706587013865 IHF dimer interface [polypeptide binding]; other site 706587013866 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 706587013867 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 706587013868 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 706587013869 Walker A motif; other site 706587013870 ATP binding site [chemical binding]; other site 706587013871 Walker B motif; other site 706587013872 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 706587013873 Peptidase family M50; Region: Peptidase_M50; pfam02163 706587013874 active site 706587013875 putative substrate binding region [chemical binding]; other site 706587013876 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 706587013877 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 706587013878 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 706587013879 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 706587013880 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 706587013881 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 706587013882 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 706587013883 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 706587013884 Walker A/P-loop; other site 706587013885 ATP binding site [chemical binding]; other site 706587013886 Q-loop/lid; other site 706587013887 ABC transporter signature motif; other site 706587013888 Walker B; other site 706587013889 D-loop; other site 706587013890 H-loop/switch region; other site 706587013891 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 706587013892 G1 box; other site 706587013893 GTP/Mg2+ binding site [chemical binding]; other site 706587013894 G2 box; other site 706587013895 Switch I region; other site 706587013896 G3 box; other site 706587013897 Switch II region; other site 706587013898 G4 box; other site 706587013899 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 706587013900 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 706587013901 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 706587013902 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 706587013903 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 706587013904 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 706587013905 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 706587013906 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 706587013907 HflX GTPase family; Region: HflX; cd01878 706587013908 G1 box; other site 706587013909 GTP/Mg2+ binding site [chemical binding]; other site 706587013910 Switch I region; other site 706587013911 G2 box; other site 706587013912 G3 box; other site 706587013913 Switch II region; other site 706587013914 G4 box; other site 706587013915 G5 box; other site 706587013916 Uncharacterized conserved protein [Function unknown]; Region: COG0398 706587013917 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 706587013918 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 706587013919 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706587013920 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 706587013921 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 706587013922 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 706587013923 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 706587013924 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 706587013925 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 706587013926 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 706587013927 NAD(P) binding site [chemical binding]; other site 706587013928 homodimer interface [polypeptide binding]; other site 706587013929 substrate binding site [chemical binding]; other site 706587013930 active site 706587013931 Uncharacterized conserved protein [Function unknown]; Region: COG1434 706587013932 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 706587013933 putative active site [active] 706587013934 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 706587013935 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 706587013936 NodB motif; other site 706587013937 active site 706587013938 catalytic site [active] 706587013939 metal binding site [ion binding]; metal-binding site 706587013940 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 706587013941 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 706587013942 bacterial Hfq-like; Region: Hfq; cd01716 706587013943 hexamer interface [polypeptide binding]; other site 706587013944 Sm1 motif; other site 706587013945 RNA binding site [nucleotide binding]; other site 706587013946 Sm2 motif; other site 706587013947 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 706587013948 active site 706587013949 putative catalytic site [active] 706587013950 phosphate binding site A [ion binding]; other site 706587013951 DNA binding site [nucleotide binding] 706587013952 metal binding site A [ion binding]; metal-binding site 706587013953 putative AP binding site [nucleotide binding]; other site 706587013954 putative metal binding site B [ion binding]; other site 706587013955 phosphate binding site B [ion binding]; other site 706587013956 MraW methylase family; Region: Methyltransf_5; cl17771 706587013957 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 706587013958 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 706587013959 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 706587013960 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 706587013961 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 706587013962 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 706587013963 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 706587013964 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 706587013965 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 706587013966 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 706587013967 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 706587013968 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 706587013969 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 706587013970 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 706587013971 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 706587013972 Mg++ binding site [ion binding]; other site 706587013973 putative catalytic motif [active] 706587013974 putative substrate binding site [chemical binding]; other site 706587013975 cell division protein FtsW; Region: ftsW; TIGR02614 706587013976 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 706587013977 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 706587013978 active site 706587013979 homodimer interface [polypeptide binding]; other site 706587013980 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 706587013981 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 706587013982 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 706587013983 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 706587013984 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 706587013985 FAD binding domain; Region: FAD_binding_4; pfam01565 706587013986 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 706587013987 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 706587013988 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 706587013989 Cell division protein FtsQ; Region: FtsQ; pfam03799 706587013990 cell division protein FtsA; Region: ftsA; TIGR01174 706587013991 Cell division protein FtsA; Region: FtsA; smart00842 706587013992 Cell division protein FtsA; Region: FtsA; pfam14450 706587013993 cell division protein FtsZ; Validated; Region: PRK09330 706587013994 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 706587013995 nucleotide binding site [chemical binding]; other site 706587013996 SulA interaction site; other site 706587013997 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 706587013998 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 706587013999 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 706587014000 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 706587014001 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 706587014002 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 706587014003 P loop; other site 706587014004 Nucleotide binding site [chemical binding]; other site 706587014005 DTAP/Switch II; other site 706587014006 Switch I; other site 706587014007 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 706587014008 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 706587014009 P loop; other site 706587014010 Nucleotide binding site [chemical binding]; other site 706587014011 DTAP/Switch II; other site 706587014012 Switch I; other site 706587014013 Carbon starvation protein CstA; Region: CstA; pfam02554 706587014014 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 706587014015 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 706587014016 Methyltransferase domain; Region: Methyltransf_23; pfam13489 706587014017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587014018 S-adenosylmethionine binding site [chemical binding]; other site 706587014019 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587014020 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 706587014021 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587014022 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706587014023 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 706587014024 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 706587014025 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587014026 FeS/SAM binding site; other site 706587014027 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 706587014028 catalytic residues [active] 706587014029 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 706587014030 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 706587014031 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 706587014032 Catalytic site [active] 706587014033 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 706587014034 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 706587014035 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 706587014036 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706587014037 catalytic residue [active] 706587014038 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 706587014039 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 706587014040 trimerization site [polypeptide binding]; other site 706587014041 active site 706587014042 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 706587014043 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706587014044 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587014045 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 706587014046 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 706587014047 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 706587014048 active site 706587014049 metal binding site [ion binding]; metal-binding site 706587014050 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 706587014051 Glycoprotease family; Region: Peptidase_M22; pfam00814 706587014052 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 706587014053 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 706587014054 active site 706587014055 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 706587014056 protein binding site [polypeptide binding]; other site 706587014057 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 706587014058 putative substrate binding region [chemical binding]; other site 706587014059 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 706587014060 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 706587014061 active site 706587014062 (T/H)XGH motif; other site 706587014063 Oligomerisation domain; Region: Oligomerisation; pfam02410 706587014064 primosome assembly protein PriA; Validated; Region: PRK05580 706587014065 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 706587014066 trimer interface [polypeptide binding]; other site 706587014067 putative Zn binding site [ion binding]; other site 706587014068 Sodium Bile acid symporter family; Region: SBF; cl17470 706587014069 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 706587014070 Catalytic domain of Protein Kinases; Region: PKc; cd00180 706587014071 active site 706587014072 ATP binding site [chemical binding]; other site 706587014073 substrate binding site [chemical binding]; other site 706587014074 activation loop (A-loop); other site 706587014075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587014076 binding surface 706587014077 TPR motif; other site 706587014078 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 706587014079 structural tetrad; other site 706587014080 PQQ-like domain; Region: PQQ_2; pfam13360 706587014081 FOG: WD40 repeat [General function prediction only]; Region: COG2319 706587014082 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 706587014083 structural tetrad; other site 706587014084 DNA topoisomerase I; Validated; Region: PRK06599 706587014085 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 706587014086 active site 706587014087 interdomain interaction site; other site 706587014088 putative metal-binding site [ion binding]; other site 706587014089 nucleotide binding site [chemical binding]; other site 706587014090 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 706587014091 domain I; other site 706587014092 DNA binding groove [nucleotide binding] 706587014093 phosphate binding site [ion binding]; other site 706587014094 domain II; other site 706587014095 domain III; other site 706587014096 nucleotide binding site [chemical binding]; other site 706587014097 catalytic site [active] 706587014098 domain IV; other site 706587014099 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 706587014100 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 706587014101 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 706587014102 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 706587014103 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 706587014104 DNA protecting protein DprA; Region: dprA; TIGR00732 706587014105 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 706587014106 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 706587014107 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 706587014108 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 706587014109 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 706587014110 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 706587014111 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 706587014112 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 706587014113 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 706587014114 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 706587014115 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 706587014116 4Fe-4S binding domain; Region: Fer4; cl02805 706587014117 4Fe-4S binding domain; Region: Fer4; pfam00037 706587014118 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 706587014119 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587014120 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 706587014121 catalytic loop [active] 706587014122 iron binding site [ion binding]; other site 706587014123 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 706587014124 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 706587014125 [4Fe-4S] binding site [ion binding]; other site 706587014126 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 706587014127 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 706587014128 SLBB domain; Region: SLBB; pfam10531 706587014129 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 706587014130 NADH dehydrogenase subunit E; Validated; Region: PRK07539 706587014131 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 706587014132 putative dimer interface [polypeptide binding]; other site 706587014133 [2Fe-2S] cluster binding site [ion binding]; other site 706587014134 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 706587014135 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 706587014136 NADH dehydrogenase subunit D; Validated; Region: PRK06075 706587014137 NADH dehydrogenase subunit B; Validated; Region: PRK06411 706587014138 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 706587014139 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 706587014140 putative active site; other site 706587014141 putative triphosphate binding site [ion binding]; other site 706587014142 putative metal binding residues [ion binding]; other site 706587014143 coenzyme A disulfide reductase; Provisional; Region: PRK13512 706587014144 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587014145 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587014146 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 706587014147 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 706587014148 substrate binding pocket [chemical binding]; other site 706587014149 dimer interface [polypeptide binding]; other site 706587014150 inhibitor binding site; inhibition site 706587014151 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 706587014152 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 706587014153 B12 binding site [chemical binding]; other site 706587014154 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 706587014155 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 706587014156 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 706587014157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587014158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587014159 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 706587014160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706587014161 DNA-binding site [nucleotide binding]; DNA binding site 706587014162 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 706587014163 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 706587014164 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 706587014165 B12 binding site [chemical binding]; other site 706587014166 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 706587014167 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 706587014168 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 706587014169 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 706587014170 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587014171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587014172 active site 706587014173 phosphorylation site [posttranslational modification] 706587014174 intermolecular recognition site; other site 706587014175 dimerization interface [polypeptide binding]; other site 706587014176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587014177 Walker A motif; other site 706587014178 ATP binding site [chemical binding]; other site 706587014179 Walker B motif; other site 706587014180 arginine finger; other site 706587014181 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587014182 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 706587014183 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 706587014184 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587014185 dimerization interface [polypeptide binding]; other site 706587014186 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587014187 dimer interface [polypeptide binding]; other site 706587014188 phosphorylation site [posttranslational modification] 706587014189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587014190 ATP binding site [chemical binding]; other site 706587014191 Mg2+ binding site [ion binding]; other site 706587014192 G-X-G motif; other site 706587014193 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587014194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587014195 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587014196 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 706587014197 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 706587014198 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 706587014199 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706587014200 ABC-ATPase subunit interface; other site 706587014201 dimer interface [polypeptide binding]; other site 706587014202 putative PBP binding regions; other site 706587014203 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 706587014204 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 706587014205 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 706587014206 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 706587014207 intersubunit interface [polypeptide binding]; other site 706587014208 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 706587014209 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 706587014210 Colicin V production protein; Region: Colicin_V; pfam02674 706587014211 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 706587014212 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 706587014213 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 706587014214 Peptidase family M23; Region: Peptidase_M23; pfam01551 706587014215 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587014216 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587014217 putative active site [active] 706587014218 heme pocket [chemical binding]; other site 706587014219 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587014220 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587014221 putative active site [active] 706587014222 heme pocket [chemical binding]; other site 706587014223 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587014224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587014225 putative active site [active] 706587014226 heme pocket [chemical binding]; other site 706587014227 PAS domain; Region: PAS_8; pfam13188 706587014228 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 706587014229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587014230 dimer interface [polypeptide binding]; other site 706587014231 phosphorylation site [posttranslational modification] 706587014232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587014233 ATP binding site [chemical binding]; other site 706587014234 Mg2+ binding site [ion binding]; other site 706587014235 G-X-G motif; other site 706587014236 Response regulator receiver domain; Region: Response_reg; pfam00072 706587014237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587014238 active site 706587014239 phosphorylation site [posttranslational modification] 706587014240 intermolecular recognition site; other site 706587014241 dimerization interface [polypeptide binding]; other site 706587014242 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 706587014243 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706587014244 ligand binding site [chemical binding]; other site 706587014245 flexible hinge region; other site 706587014246 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587014247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 706587014248 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 706587014249 4Fe-4S binding domain; Region: Fer4_5; pfam12801 706587014250 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 706587014251 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 706587014252 Walker A/P-loop; other site 706587014253 ATP binding site [chemical binding]; other site 706587014254 Q-loop/lid; other site 706587014255 ABC transporter signature motif; other site 706587014256 Walker B; other site 706587014257 D-loop; other site 706587014258 H-loop/switch region; other site 706587014259 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 706587014260 Permease; Region: Permease; pfam02405 706587014261 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 706587014262 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 706587014263 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587014264 Zn2+ binding site [ion binding]; other site 706587014265 Mg2+ binding site [ion binding]; other site 706587014266 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 706587014267 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587014268 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587014269 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 706587014270 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587014271 catalytic loop [active] 706587014272 iron binding site [ion binding]; other site 706587014273 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587014274 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 706587014275 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 706587014276 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706587014277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587014278 putative substrate translocation pore; other site 706587014279 Predicted permeases [General function prediction only]; Region: COG0795 706587014280 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 706587014281 Response regulator receiver domain; Region: Response_reg; pfam00072 706587014282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587014283 active site 706587014284 phosphorylation site [posttranslational modification] 706587014285 intermolecular recognition site; other site 706587014286 dimerization interface [polypeptide binding]; other site 706587014287 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 706587014288 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 706587014289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587014290 active site 706587014291 phosphorylation site [posttranslational modification] 706587014292 intermolecular recognition site; other site 706587014293 dimerization interface [polypeptide binding]; other site 706587014294 CheB methylesterase; Region: CheB_methylest; pfam01339 706587014295 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 706587014296 putative CheA interaction surface; other site 706587014297 Cache domain; Region: Cache_1; pfam02743 706587014298 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 706587014299 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587014300 dimerization interface [polypeptide binding]; other site 706587014301 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706587014302 dimer interface [polypeptide binding]; other site 706587014303 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 706587014304 putative CheW interface [polypeptide binding]; other site 706587014305 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706587014306 dimer interface [polypeptide binding]; other site 706587014307 Response regulator receiver domain; Region: Response_reg; pfam00072 706587014308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587014309 active site 706587014310 phosphorylation site [posttranslational modification] 706587014311 intermolecular recognition site; other site 706587014312 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 706587014313 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587014314 dimerization interface [polypeptide binding]; other site 706587014315 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 706587014316 putative binding surface; other site 706587014317 active site 706587014318 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 706587014319 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 706587014320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587014321 ATP binding site [chemical binding]; other site 706587014322 Mg2+ binding site [ion binding]; other site 706587014323 G-X-G motif; other site 706587014324 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 706587014325 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 706587014326 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 706587014327 P-loop; other site 706587014328 Magnesium ion binding site [ion binding]; other site 706587014329 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 706587014330 Magnesium ion binding site [ion binding]; other site 706587014331 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 706587014332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587014333 active site 706587014334 phosphorylation site [posttranslational modification] 706587014335 intermolecular recognition site; other site 706587014336 dimerization interface [polypeptide binding]; other site 706587014337 CheB methylesterase; Region: CheB_methylest; pfam01339 706587014338 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 706587014339 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 706587014340 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 706587014341 classical (c) SDRs; Region: SDR_c; cd05233 706587014342 NAD(P) binding site [chemical binding]; other site 706587014343 active site 706587014344 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 706587014345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587014346 active site 706587014347 phosphorylation site [posttranslational modification] 706587014348 intermolecular recognition site; other site 706587014349 dimerization interface [polypeptide binding]; other site 706587014350 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706587014351 Zn2+ binding site [ion binding]; other site 706587014352 Mg2+ binding site [ion binding]; other site 706587014353 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587014354 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 706587014355 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 706587014356 oxyanion hole [active] 706587014357 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 706587014358 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 706587014359 NADP binding site [chemical binding]; other site 706587014360 dimer interface [polypeptide binding]; other site 706587014361 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 706587014362 active site residue [active] 706587014363 Uncharacterized conserved protein [Function unknown]; Region: COG1633 706587014364 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 706587014365 diiron binding motif [ion binding]; other site 706587014366 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 706587014367 NADPH bind site [chemical binding]; other site 706587014368 putative FMN binding site [chemical binding]; other site 706587014369 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 706587014370 putative FMN binding site [chemical binding]; other site 706587014371 NADPH bind site [chemical binding]; other site 706587014372 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 706587014373 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 706587014374 Competence protein; Region: Competence; pfam03772 706587014375 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 706587014376 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 706587014377 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 706587014378 Helix-turn-helix domain; Region: HTH_25; pfam13413 706587014379 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 706587014380 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 706587014381 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 706587014382 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 706587014383 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 706587014384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587014385 ABC-ATPase subunit interface; other site 706587014386 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 706587014387 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 706587014388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587014389 dimer interface [polypeptide binding]; other site 706587014390 conserved gate region; other site 706587014391 putative PBP binding loops; other site 706587014392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 706587014393 ABC-ATPase subunit interface; other site 706587014394 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 706587014395 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 706587014396 Walker A/P-loop; other site 706587014397 ATP binding site [chemical binding]; other site 706587014398 Q-loop/lid; other site 706587014399 ABC transporter signature motif; other site 706587014400 Walker B; other site 706587014401 D-loop; other site 706587014402 H-loop/switch region; other site 706587014403 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 706587014404 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587014405 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587014406 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587014407 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587014408 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587014409 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587014410 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587014411 PAS domain; Region: PAS_9; pfam13426 706587014412 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587014413 dimer interface [polypeptide binding]; other site 706587014414 phosphorylation site [posttranslational modification] 706587014415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587014416 ATP binding site [chemical binding]; other site 706587014417 G-X-G motif; other site 706587014418 Response regulator receiver domain; Region: Response_reg; pfam00072 706587014419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587014420 active site 706587014421 phosphorylation site [posttranslational modification] 706587014422 intermolecular recognition site; other site 706587014423 dimerization interface [polypeptide binding]; other site 706587014424 PAS domain; Region: PAS_9; pfam13426 706587014425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587014426 PAS domain; Region: PAS_9; pfam13426 706587014427 putative active site [active] 706587014428 heme pocket [chemical binding]; other site 706587014429 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 706587014430 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 706587014431 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706587014432 DNA binding residues [nucleotide binding] 706587014433 dimerization interface [polypeptide binding]; other site 706587014434 Double zinc ribbon; Region: DZR; pfam12773 706587014435 cyclase homology domain; Region: CHD; cd07302 706587014436 nucleotidyl binding site; other site 706587014437 metal binding site [ion binding]; metal-binding site 706587014438 dimer interface [polypeptide binding]; other site 706587014439 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 706587014440 AAA ATPase domain; Region: AAA_16; pfam13191 706587014441 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587014442 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 706587014443 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 706587014444 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 706587014445 inhibitor-cofactor binding pocket; inhibition site 706587014446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587014447 catalytic residue [active] 706587014448 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 706587014449 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 706587014450 Ligand binding site; other site 706587014451 Putative Catalytic site; other site 706587014452 DXD motif; other site 706587014453 Methyltransferase domain; Region: Methyltransf_23; pfam13489 706587014454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587014455 S-adenosylmethionine binding site [chemical binding]; other site 706587014456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587014457 S-adenosylmethionine binding site [chemical binding]; other site 706587014458 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 706587014459 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 706587014460 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 706587014461 G1 box; other site 706587014462 putative GEF interaction site [polypeptide binding]; other site 706587014463 GTP/Mg2+ binding site [chemical binding]; other site 706587014464 Switch I region; other site 706587014465 G2 box; other site 706587014466 G3 box; other site 706587014467 Switch II region; other site 706587014468 G4 box; other site 706587014469 G5 box; other site 706587014470 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 706587014471 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 706587014472 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 706587014473 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 706587014474 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 706587014475 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706587014476 substrate binding pocket [chemical binding]; other site 706587014477 membrane-bound complex binding site; other site 706587014478 hinge residues; other site 706587014479 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 706587014480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587014481 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 706587014482 Walker A motif; other site 706587014483 ATP binding site [chemical binding]; other site 706587014484 Walker B motif; other site 706587014485 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 706587014486 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 706587014487 Protein export membrane protein; Region: SecD_SecF; pfam02355 706587014488 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 706587014489 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 706587014490 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 706587014491 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 706587014492 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 706587014493 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 706587014494 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587014495 active site 706587014496 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 706587014497 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 706587014498 HIGH motif; other site 706587014499 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 706587014500 active site 706587014501 KMSKS motif; other site 706587014502 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 706587014503 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 706587014504 Protein of unknown function (DUF502); Region: DUF502; cl01107 706587014505 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 706587014506 CoenzymeA binding site [chemical binding]; other site 706587014507 subunit interaction site [polypeptide binding]; other site 706587014508 PHB binding site; other site 706587014509 CAAX protease self-immunity; Region: Abi; pfam02517 706587014510 Uncharacterized conserved protein [Function unknown]; Region: COG2128 706587014511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587014512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587014513 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 706587014514 muropeptide transporter; Reviewed; Region: ampG; PRK11902 706587014515 muropeptide transporter; Validated; Region: ampG; cl17669 706587014516 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 706587014517 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 706587014518 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 706587014519 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 706587014520 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587014521 FtsX-like permease family; Region: FtsX; pfam02687 706587014522 Dynamin family; Region: Dynamin_N; pfam00350 706587014523 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 706587014524 G1 box; other site 706587014525 GTP/Mg2+ binding site [chemical binding]; other site 706587014526 G2 box; other site 706587014527 Switch I region; other site 706587014528 G3 box; other site 706587014529 Switch II region; other site 706587014530 G4 box; other site 706587014531 pyruvate phosphate dikinase; Provisional; Region: PRK09279 706587014532 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 706587014533 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 706587014534 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 706587014535 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 706587014536 CoenzymeA binding site [chemical binding]; other site 706587014537 subunit interaction site [polypeptide binding]; other site 706587014538 PHB binding site; other site 706587014539 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 706587014540 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 706587014541 Protein export membrane protein; Region: SecD_SecF; cl14618 706587014542 Staphylococcal nuclease homologues; Region: SNc; smart00318 706587014543 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 706587014544 Catalytic site; other site 706587014545 Chain length determinant protein; Region: Wzz; pfam02706 706587014546 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 706587014547 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 706587014548 TPR repeat; Region: TPR_11; pfam13414 706587014549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587014550 binding surface 706587014551 TPR motif; other site 706587014552 TPR repeat; Region: TPR_11; pfam13414 706587014553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587014554 TPR motif; other site 706587014555 binding surface 706587014556 TPR repeat; Region: TPR_11; pfam13414 706587014557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587014558 binding surface 706587014559 TPR motif; other site 706587014560 TPR repeat; Region: TPR_11; pfam13414 706587014561 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587014562 binding surface 706587014563 TPR motif; other site 706587014564 TPR repeat; Region: TPR_11; pfam13414 706587014565 TPR repeat; Region: TPR_11; pfam13414 706587014566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587014567 binding surface 706587014568 TPR motif; other site 706587014569 TPR repeat; Region: TPR_11; pfam13414 706587014570 TPR repeat; Region: TPR_11; pfam13414 706587014571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587014572 TPR motif; other site 706587014573 binding surface 706587014574 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587014575 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 706587014576 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 706587014577 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 706587014578 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 706587014579 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 706587014580 PYR/PP interface [polypeptide binding]; other site 706587014581 dimer interface [polypeptide binding]; other site 706587014582 TPP binding site [chemical binding]; other site 706587014583 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 706587014584 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 706587014585 TPP-binding site [chemical binding]; other site 706587014586 dimer interface [polypeptide binding]; other site 706587014587 Bacterial SH3 domain; Region: SH3_3; cl17532 706587014588 Cupin domain; Region: Cupin_2; pfam07883 706587014589 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 706587014590 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587014591 acyl-activating enzyme (AAE) consensus motif; other site 706587014592 AMP binding site [chemical binding]; other site 706587014593 active site 706587014594 CoA binding site [chemical binding]; other site 706587014595 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587014596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587014597 active site 706587014598 phosphorylation site [posttranslational modification] 706587014599 intermolecular recognition site; other site 706587014600 dimerization interface [polypeptide binding]; other site 706587014601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587014602 Walker A motif; other site 706587014603 ATP binding site [chemical binding]; other site 706587014604 Walker B motif; other site 706587014605 arginine finger; other site 706587014606 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587014607 PAS domain S-box; Region: sensory_box; TIGR00229 706587014608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587014609 putative active site [active] 706587014610 heme pocket [chemical binding]; other site 706587014611 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587014612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587014613 putative active site [active] 706587014614 heme pocket [chemical binding]; other site 706587014615 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587014616 dimer interface [polypeptide binding]; other site 706587014617 phosphorylation site [posttranslational modification] 706587014618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587014619 ATP binding site [chemical binding]; other site 706587014620 Mg2+ binding site [ion binding]; other site 706587014621 G-X-G motif; other site 706587014622 HPP family; Region: HPP; pfam04982 706587014623 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 706587014624 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 706587014625 dimer interface [polypeptide binding]; other site 706587014626 putative functional site; other site 706587014627 putative MPT binding site; other site 706587014628 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 706587014629 FAD binding site [chemical binding]; other site 706587014630 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 706587014631 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 706587014632 CPxP motif; other site 706587014633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587014634 PAS domain; Region: PAS_9; pfam13426 706587014635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587014636 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 706587014637 Walker A motif; other site 706587014638 ATP binding site [chemical binding]; other site 706587014639 Walker B motif; other site 706587014640 arginine finger; other site 706587014641 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587014642 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 706587014643 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 706587014644 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 706587014645 Walker A/P-loop; other site 706587014646 ATP binding site [chemical binding]; other site 706587014647 Q-loop/lid; other site 706587014648 ABC transporter signature motif; other site 706587014649 Walker B; other site 706587014650 D-loop; other site 706587014651 H-loop/switch region; other site 706587014652 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 706587014653 Walker A/P-loop; other site 706587014654 ATP binding site [chemical binding]; other site 706587014655 Q-loop/lid; other site 706587014656 ABC transporter signature motif; other site 706587014657 Walker B; other site 706587014658 D-loop; other site 706587014659 H-loop/switch region; other site 706587014660 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 706587014661 Protein of unknown function (DUF497); Region: DUF497; pfam04365 706587014662 Protein of unknown function (DUF3680); Region: DUF3680; pfam12441 706587014663 Transcriptional regulators [Transcription]; Region: FadR; COG2186 706587014664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706587014665 DNA-binding site [nucleotide binding]; DNA binding site 706587014666 FCD domain; Region: FCD; pfam07729 706587014667 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 706587014668 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 706587014669 Predicted aconitase [General function prediction only]; Region: COG1679 706587014670 Protein of unknown function (DUF521); Region: DUF521; pfam04412 706587014671 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 706587014672 substrate binding site [chemical binding]; other site 706587014673 DsrE/DsrF-like family; Region: DrsE; cl00672 706587014674 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 706587014675 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 706587014676 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 706587014677 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 706587014678 DctM-like transporters; Region: DctM; pfam06808 706587014679 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 706587014680 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 706587014681 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 706587014682 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587014683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587014684 putative active site [active] 706587014685 heme pocket [chemical binding]; other site 706587014686 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587014687 dimer interface [polypeptide binding]; other site 706587014688 phosphorylation site [posttranslational modification] 706587014689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587014690 ATP binding site [chemical binding]; other site 706587014691 Mg2+ binding site [ion binding]; other site 706587014692 G-X-G motif; other site 706587014693 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587014694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587014695 active site 706587014696 phosphorylation site [posttranslational modification] 706587014697 intermolecular recognition site; other site 706587014698 dimerization interface [polypeptide binding]; other site 706587014699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587014700 Walker A motif; other site 706587014701 ATP binding site [chemical binding]; other site 706587014702 Walker B motif; other site 706587014703 arginine finger; other site 706587014704 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587014705 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 706587014706 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 706587014707 putative dimer interface [polypeptide binding]; other site 706587014708 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 706587014709 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 706587014710 Cell division protein 48 (CDC48), domain 2; Region: CDC48_2; pfam02933 706587014711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587014712 Walker A motif; other site 706587014713 ATP binding site [chemical binding]; other site 706587014714 Walker B motif; other site 706587014715 arginine finger; other site 706587014716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587014717 ATP binding site [chemical binding]; other site 706587014718 Walker B motif; other site 706587014719 arginine finger; other site 706587014720 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 706587014721 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 706587014722 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587014723 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587014724 putative active site [active] 706587014725 heme pocket [chemical binding]; other site 706587014726 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587014727 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587014728 putative active site [active] 706587014729 heme pocket [chemical binding]; other site 706587014730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587014731 dimer interface [polypeptide binding]; other site 706587014732 phosphorylation site [posttranslational modification] 706587014733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587014734 ATP binding site [chemical binding]; other site 706587014735 G-X-G motif; other site 706587014736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587014737 Response regulator receiver domain; Region: Response_reg; pfam00072 706587014738 active site 706587014739 phosphorylation site [posttranslational modification] 706587014740 intermolecular recognition site; other site 706587014741 dimerization interface [polypeptide binding]; other site 706587014742 Acylphosphatase; Region: Acylphosphatase; cl00551 706587014743 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 706587014744 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 706587014745 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 706587014746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587014747 Walker A motif; other site 706587014748 ATP binding site [chemical binding]; other site 706587014749 Walker B motif; other site 706587014750 arginine finger; other site 706587014751 threonine synthase; Validated; Region: PRK06260 706587014752 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 706587014753 Gas vesicle protein G; Region: GvpG; pfam05120 706587014754 Gas vesicle protein; Region: Gas_vesicle; pfam00741 706587014755 Gas vesicle protein K; Region: GvpK; pfam05121 706587014756 Gas vesicle protein; Region: Gas_vesicle; pfam00741 706587014757 PAS domain; Region: PAS_9; pfam13426 706587014758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587014759 Response regulator receiver domain; Region: Response_reg; pfam00072 706587014760 active site 706587014761 phosphorylation site [posttranslational modification] 706587014762 intermolecular recognition site; other site 706587014763 dimerization interface [polypeptide binding]; other site 706587014764 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 706587014765 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 706587014766 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 706587014767 G1 box; other site 706587014768 GTP/Mg2+ binding site [chemical binding]; other site 706587014769 Switch I region; other site 706587014770 G2 box; other site 706587014771 G3 box; other site 706587014772 Switch II region; other site 706587014773 G4 box; other site 706587014774 G5 box; other site 706587014775 Nucleoside recognition; Region: Gate; pfam07670 706587014776 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 706587014777 Nucleoside recognition; Region: Gate; pfam07670 706587014778 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 706587014779 FeoA domain; Region: FeoA; pfam04023 706587014780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587014781 dimer interface [polypeptide binding]; other site 706587014782 phosphorylation site [posttranslational modification] 706587014783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587014784 ATP binding site [chemical binding]; other site 706587014785 Mg2+ binding site [ion binding]; other site 706587014786 G-X-G motif; other site 706587014787 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 706587014788 Methyltransferase domain; Region: Methyltransf_23; pfam13489 706587014789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587014790 S-adenosylmethionine binding site [chemical binding]; other site 706587014791 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 706587014792 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 706587014793 metal binding site [ion binding]; metal-binding site 706587014794 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587014795 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587014796 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587014797 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587014798 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587014799 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587014800 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587014801 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 706587014802 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 706587014803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706587014804 motif II; other site 706587014805 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 706587014806 nucleophile elbow; other site 706587014807 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 706587014808 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 706587014809 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 706587014810 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 706587014811 DctM-like transporters; Region: DctM; pfam06808 706587014812 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 706587014813 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 706587014814 Transglycosylase; Region: Transgly; pfam00912 706587014815 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 706587014816 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 706587014817 Found in ATP-dependent protease La (LON); Region: LON; smart00464 706587014818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587014819 Walker A motif; other site 706587014820 ATP binding site [chemical binding]; other site 706587014821 Walker B motif; other site 706587014822 arginine finger; other site 706587014823 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 706587014824 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 706587014825 putative acyl-acceptor binding pocket; other site 706587014826 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 706587014827 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 706587014828 catalytic residues [active] 706587014829 HEAT repeats; Region: HEAT_2; pfam13646 706587014830 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 706587014831 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 706587014832 N-acetyl-D-glucosamine binding site [chemical binding]; other site 706587014833 catalytic residue [active] 706587014834 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 706587014835 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 706587014836 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 706587014837 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 706587014838 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587014839 acyl-activating enzyme (AAE) consensus motif; other site 706587014840 active site 706587014841 AMP binding site [chemical binding]; other site 706587014842 CoA binding site [chemical binding]; other site 706587014843 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 706587014844 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587014845 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 706587014846 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587014847 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 706587014848 acyl-activating enzyme (AAE) consensus motif; other site 706587014849 putative AMP binding site [chemical binding]; other site 706587014850 putative active site [active] 706587014851 putative CoA binding site [chemical binding]; other site 706587014852 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587014853 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587014854 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587014855 Radical SAM superfamily; Region: Radical_SAM; pfam04055 706587014856 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587014857 FeS/SAM binding site; other site 706587014858 prolyl-tRNA synthetase; Provisional; Region: PRK09194 706587014859 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 706587014860 dimer interface [polypeptide binding]; other site 706587014861 motif 1; other site 706587014862 active site 706587014863 motif 2; other site 706587014864 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 706587014865 putative deacylase active site [active] 706587014866 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 706587014867 active site 706587014868 motif 3; other site 706587014869 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 706587014870 anticodon binding site; other site 706587014871 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 706587014872 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 706587014873 Protein of unknown function; Region: DUF3971; pfam13116 706587014874 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 706587014875 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 706587014876 RDD family; Region: RDD; pfam06271 706587014877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 706587014878 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 706587014879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587014880 Coenzyme A binding pocket [chemical binding]; other site 706587014881 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 706587014882 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587014883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587014884 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587014885 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587014886 enoyl-CoA hydratase; Provisional; Region: PRK06142 706587014887 substrate binding site [chemical binding]; other site 706587014888 oxyanion hole (OAH) forming residues; other site 706587014889 trimer interface [polypeptide binding]; other site 706587014890 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 706587014891 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 706587014892 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 706587014893 active site 706587014894 FMN binding site [chemical binding]; other site 706587014895 substrate binding site [chemical binding]; other site 706587014896 putative catalytic residue [active] 706587014897 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587014898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587014899 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 706587014900 MoaD interaction [polypeptide binding]; other site 706587014901 active site residues [active] 706587014902 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 706587014903 putative amphipathic alpha helix; other site 706587014904 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 706587014905 TPR repeat; Region: TPR_11; pfam13414 706587014906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587014907 binding surface 706587014908 TPR motif; other site 706587014909 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706587014910 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 706587014911 Omptin family; Region: Omptin; cl01886 706587014912 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 706587014913 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 706587014914 Cysteine-rich domain; Region: CCG; pfam02754 706587014915 Cysteine-rich domain; Region: CCG; pfam02754 706587014916 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 706587014917 glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316 706587014918 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587014919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587014920 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 706587014921 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 706587014922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706587014923 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 706587014924 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 706587014925 B12 binding domain; Region: B12-binding; pfam02310 706587014926 B12 binding site [chemical binding]; other site 706587014927 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 706587014928 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587014929 FeS/SAM binding site; other site 706587014930 hypothetical protein; Validated; Region: PRK00153 706587014931 recombination protein RecR; Reviewed; Region: recR; PRK00076 706587014932 RecR protein; Region: RecR; pfam02132 706587014933 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 706587014934 putative active site [active] 706587014935 putative metal-binding site [ion binding]; other site 706587014936 tetramer interface [polypeptide binding]; other site 706587014937 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 706587014938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706587014939 DNA-binding site [nucleotide binding]; DNA binding site 706587014940 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706587014941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587014942 homodimer interface [polypeptide binding]; other site 706587014943 catalytic residue [active] 706587014944 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587014945 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587014946 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587014947 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 706587014948 FtsX-like permease family; Region: FtsX; pfam02687 706587014949 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 706587014950 putative acyltransferase; Provisional; Region: PRK05790 706587014951 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 706587014952 dimer interface [polypeptide binding]; other site 706587014953 active site 706587014954 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 706587014955 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 706587014956 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 706587014957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587014958 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706587014959 putative substrate translocation pore; other site 706587014960 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587014961 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587014962 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587014963 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587014964 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587014965 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587014966 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587014967 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587014968 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587014969 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 706587014970 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587014971 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587014972 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587014973 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587014974 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587014975 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 706587014976 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 706587014977 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706587014978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587014979 active site 706587014980 phosphorylation site [posttranslational modification] 706587014981 intermolecular recognition site; other site 706587014982 dimerization interface [polypeptide binding]; other site 706587014983 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587014984 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587014985 putative active site [active] 706587014986 heme pocket [chemical binding]; other site 706587014987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587014988 dimer interface [polypeptide binding]; other site 706587014989 phosphorylation site [posttranslational modification] 706587014990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587014991 ATP binding site [chemical binding]; other site 706587014992 Mg2+ binding site [ion binding]; other site 706587014993 G-X-G motif; other site 706587014994 Response regulator receiver domain; Region: Response_reg; pfam00072 706587014995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587014996 active site 706587014997 phosphorylation site [posttranslational modification] 706587014998 intermolecular recognition site; other site 706587014999 dimerization interface [polypeptide binding]; other site 706587015000 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015001 PAS domain; Region: PAS_9; pfam13426 706587015002 putative active site [active] 706587015003 heme pocket [chemical binding]; other site 706587015004 PAS domain S-box; Region: sensory_box; TIGR00229 706587015005 PAS domain; Region: PAS; smart00091 706587015006 putative active site [active] 706587015007 heme pocket [chemical binding]; other site 706587015008 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 706587015009 ApbE family; Region: ApbE; pfam02424 706587015010 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 706587015011 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 706587015012 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 706587015013 active site 706587015014 catalytic tetrad [active] 706587015015 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 706587015016 Glucose inhibited division protein A; Region: GIDA; pfam01134 706587015017 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 706587015018 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 706587015019 B12 binding site [chemical binding]; other site 706587015020 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 706587015021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587015022 FeS/SAM binding site; other site 706587015023 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 706587015024 Sulfatase; Region: Sulfatase; pfam00884 706587015025 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 706587015026 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 706587015027 conserved cys residue [active] 706587015028 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 706587015029 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 706587015030 RNase_H superfamily; Region: RNase_H_2; pfam13482 706587015031 PBP superfamily domain; Region: PBP_like_2; cl17296 706587015032 Ankyrin repeat; Region: Ank; pfam00023 706587015033 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587015034 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587015035 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587015036 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587015037 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 706587015038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587015039 active site 706587015040 phosphorylation site [posttranslational modification] 706587015041 intermolecular recognition site; other site 706587015042 dimerization interface [polypeptide binding]; other site 706587015043 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706587015044 DNA binding site [nucleotide binding] 706587015045 HAMP domain; Region: HAMP; pfam00672 706587015046 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587015047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015048 putative active site [active] 706587015049 heme pocket [chemical binding]; other site 706587015050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587015051 dimer interface [polypeptide binding]; other site 706587015052 phosphorylation site [posttranslational modification] 706587015053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587015054 ATP binding site [chemical binding]; other site 706587015055 Mg2+ binding site [ion binding]; other site 706587015056 G-X-G motif; other site 706587015057 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 706587015058 PhoU domain; Region: PhoU; pfam01895 706587015059 PhoU domain; Region: PhoU; pfam01895 706587015060 GYD domain; Region: GYD; cl01743 706587015061 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG2881 706587015062 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 706587015063 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706587015064 active site 706587015065 Bacterial sugar transferase; Region: Bac_transf; pfam02397 706587015066 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 706587015067 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 706587015068 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 706587015069 NAD binding site [chemical binding]; other site 706587015070 substrate binding site [chemical binding]; other site 706587015071 active site 706587015072 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 706587015073 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 706587015074 inhibitor-cofactor binding pocket; inhibition site 706587015075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587015076 catalytic residue [active] 706587015077 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 706587015078 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 706587015079 inhibitor-cofactor binding pocket; inhibition site 706587015080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587015081 catalytic residue [active] 706587015082 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 706587015083 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 706587015084 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587015085 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 706587015086 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 706587015087 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 706587015088 SLBB domain; Region: SLBB; pfam10531 706587015089 TPR repeat; Region: TPR_11; pfam13414 706587015090 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587015091 binding surface 706587015092 TPR motif; other site 706587015093 TPR repeat; Region: TPR_11; pfam13414 706587015094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587015095 binding surface 706587015096 TPR motif; other site 706587015097 TPR repeat; Region: TPR_11; pfam13414 706587015098 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 706587015099 UbiA prenyltransferase family; Region: UbiA; pfam01040 706587015100 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 706587015101 OstA-like protein; Region: OstA; cl00844 706587015102 Organic solvent tolerance protein; Region: OstA_C; pfam04453 706587015103 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 706587015104 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 706587015105 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 706587015106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 706587015107 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 706587015108 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 706587015109 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 706587015110 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587015111 acyl-activating enzyme (AAE) consensus motif; other site 706587015112 AMP binding site [chemical binding]; other site 706587015113 active site 706587015114 CoA binding site [chemical binding]; other site 706587015115 Response regulator receiver domain; Region: Response_reg; pfam00072 706587015116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587015117 active site 706587015118 phosphorylation site [posttranslational modification] 706587015119 intermolecular recognition site; other site 706587015120 PAS domain S-box; Region: sensory_box; TIGR00229 706587015121 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015122 putative active site [active] 706587015123 heme pocket [chemical binding]; other site 706587015124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587015125 dimer interface [polypeptide binding]; other site 706587015126 phosphorylation site [posttranslational modification] 706587015127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587015128 ATP binding site [chemical binding]; other site 706587015129 Mg2+ binding site [ion binding]; other site 706587015130 G-X-G motif; other site 706587015131 Response regulator receiver domain; Region: Response_reg; pfam00072 706587015132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587015133 active site 706587015134 phosphorylation site [posttranslational modification] 706587015135 intermolecular recognition site; other site 706587015136 dimerization interface [polypeptide binding]; other site 706587015137 PAS domain S-box; Region: sensory_box; TIGR00229 706587015138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015139 putative active site [active] 706587015140 heme pocket [chemical binding]; other site 706587015141 PAS domain S-box; Region: sensory_box; TIGR00229 706587015142 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015143 putative active site [active] 706587015144 heme pocket [chemical binding]; other site 706587015145 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015146 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587015147 putative active site [active] 706587015148 heme pocket [chemical binding]; other site 706587015149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015150 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587015151 putative active site [active] 706587015152 heme pocket [chemical binding]; other site 706587015153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015154 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587015155 putative active site [active] 706587015156 heme pocket [chemical binding]; other site 706587015157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015158 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587015159 putative active site [active] 706587015160 heme pocket [chemical binding]; other site 706587015161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015162 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587015163 putative active site [active] 706587015164 heme pocket [chemical binding]; other site 706587015165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015166 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 706587015167 putative active site [active] 706587015168 heme pocket [chemical binding]; other site 706587015169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015170 putative active site [active] 706587015171 heme pocket [chemical binding]; other site 706587015172 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 706587015173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015174 putative active site [active] 706587015175 heme pocket [chemical binding]; other site 706587015176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587015177 dimer interface [polypeptide binding]; other site 706587015178 phosphorylation site [posttranslational modification] 706587015179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587015180 ATP binding site [chemical binding]; other site 706587015181 Mg2+ binding site [ion binding]; other site 706587015182 G-X-G motif; other site 706587015183 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 706587015184 catalytic residues [active] 706587015185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587015186 Coenzyme A binding pocket [chemical binding]; other site 706587015187 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 706587015188 EamA-like transporter family; Region: EamA; pfam00892 706587015189 EamA-like transporter family; Region: EamA; pfam00892 706587015190 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 706587015191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587015192 putative substrate translocation pore; other site 706587015193 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 706587015194 Putative zinc-finger; Region: zf-HC2; pfam13490 706587015195 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 706587015196 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706587015197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706587015198 DNA binding residues [nucleotide binding] 706587015199 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 706587015200 Transglycosylase; Region: Transgly; pfam00912 706587015201 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 706587015202 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 706587015203 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 706587015204 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 706587015205 protein binding site [polypeptide binding]; other site 706587015206 SnoaL-like domain; Region: SnoaL_3; pfam13474 706587015207 SnoaL-like domain; Region: SnoaL_2; pfam12680 706587015208 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 706587015209 active site 706587015210 Int/Topo IB signature motif; other site 706587015211 catalytic residues [active] 706587015212 DNA binding site [nucleotide binding] 706587015213 Helix-turn-helix domain; Region: HTH_17; pfam12728 706587015214 His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976 706587015215 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 706587015216 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587015217 FeS/SAM binding site; other site 706587015218 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 706587015219 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 706587015220 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587015221 FeS/SAM binding site; other site 706587015222 Staphylococcal nuclease homologues; Region: SNc; smart00318 706587015223 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 706587015224 Catalytic site; other site 706587015225 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 706587015226 Helix-turn-helix domain; Region: HTH_36; pfam13730 706587015227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587015228 non-specific DNA binding site [nucleotide binding]; other site 706587015229 salt bridge; other site 706587015230 sequence-specific DNA binding site [nucleotide binding]; other site 706587015231 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 706587015232 Cadherin repeat-like domain; Region: CA_like; cl15786 706587015233 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 706587015234 active site 706587015235 catalytic residues [active] 706587015236 DNA binding site [nucleotide binding] 706587015237 Int/Topo IB signature motif; other site 706587015238 Helix-turn-helix domain; Region: HTH_17; pfam12728 706587015239 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 706587015240 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 706587015241 Catalytic domain of Protein Kinases; Region: PKc; cd00180 706587015242 active site 706587015243 ATP binding site [chemical binding]; other site 706587015244 substrate binding site [chemical binding]; other site 706587015245 activation loop (A-loop); other site 706587015246 AAA ATPase domain; Region: AAA_16; pfam13191 706587015247 Predicted ATPase [General function prediction only]; Region: COG3899 706587015248 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706587015249 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 706587015250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587015251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587015252 dimer interface [polypeptide binding]; other site 706587015253 phosphorylation site [posttranslational modification] 706587015254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587015255 ATP binding site [chemical binding]; other site 706587015256 Mg2+ binding site [ion binding]; other site 706587015257 G-X-G motif; other site 706587015258 Response regulator receiver domain; Region: Response_reg; pfam00072 706587015259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587015260 active site 706587015261 phosphorylation site [posttranslational modification] 706587015262 intermolecular recognition site; other site 706587015263 dimerization interface [polypeptide binding]; other site 706587015264 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 706587015265 putative binding surface; other site 706587015266 active site 706587015267 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706587015268 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 706587015269 substrate binding pocket [chemical binding]; other site 706587015270 membrane-bound complex binding site; other site 706587015271 hinge residues; other site 706587015272 Uncharacterized conserved protein [Function unknown]; Region: COG3379 706587015273 Uncharacterized conserved protein [Function unknown]; Region: COG3379 706587015274 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 706587015275 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 706587015276 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 706587015277 DctM-like transporters; Region: DctM; pfam06808 706587015278 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 706587015279 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706587015280 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 706587015281 catalytic residues [active] 706587015282 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 706587015283 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706587015284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587015285 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 706587015286 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 706587015287 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 706587015288 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 706587015289 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 706587015290 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706587015291 N-terminal plug; other site 706587015292 ligand-binding site [chemical binding]; other site 706587015293 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 706587015294 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 706587015295 Walker A/P-loop; other site 706587015296 ATP binding site [chemical binding]; other site 706587015297 Q-loop/lid; other site 706587015298 ABC transporter signature motif; other site 706587015299 Walker B; other site 706587015300 D-loop; other site 706587015301 H-loop/switch region; other site 706587015302 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 706587015303 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 706587015304 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 706587015305 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 706587015306 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 706587015307 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 706587015308 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 706587015309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587015310 S-adenosylmethionine binding site [chemical binding]; other site 706587015311 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 706587015312 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 706587015313 G1 box; other site 706587015314 GTP/Mg2+ binding site [chemical binding]; other site 706587015315 Switch I region; other site 706587015316 G2 box; other site 706587015317 Switch II region; other site 706587015318 G3 box; other site 706587015319 G4 box; other site 706587015320 G5 box; other site 706587015321 biotin synthase; Provisional; Region: PRK07094 706587015322 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 706587015323 FeS/SAM binding site; other site 706587015324 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 706587015325 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 706587015326 Aspartase; Region: Aspartase; cd01357 706587015327 active sites [active] 706587015328 tetramer interface [polypeptide binding]; other site 706587015329 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 706587015330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587015331 FeS/SAM binding site; other site 706587015332 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 706587015333 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 706587015334 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 706587015335 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 706587015336 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 706587015337 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 706587015338 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 706587015339 FG-GAP repeat; Region: FG-GAP_2; pfam14312 706587015340 FG-GAP repeat; Region: FG-GAP_2; pfam14312 706587015341 FG-GAP repeat; Region: FG-GAP_2; pfam14312 706587015342 FG-GAP repeat; Region: FG-GAP_2; pfam14312 706587015343 FG-GAP repeat; Region: FG-GAP_2; pfam14312 706587015344 FG-GAP repeat; Region: FG-GAP_2; pfam14312 706587015345 FG-GAP repeat; Region: FG-GAP_2; pfam14312 706587015346 FG-GAP repeat; Region: FG-GAP_2; pfam14312 706587015347 FG-GAP repeat; Region: FG-GAP_2; pfam14312 706587015348 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 706587015349 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 706587015350 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587015351 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587015352 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587015353 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587015354 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587015355 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587015356 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587015357 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587015358 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587015359 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587015360 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587015361 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587015362 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587015363 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587015364 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587015365 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 706587015366 reactive center loop; other site 706587015367 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587015368 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587015369 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587015370 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587015371 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587015372 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 706587015373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 706587015374 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 706587015375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587015376 dimer interface [polypeptide binding]; other site 706587015377 conserved gate region; other site 706587015378 putative PBP binding loops; other site 706587015379 ABC-ATPase subunit interface; other site 706587015380 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 706587015381 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 706587015382 Walker A/P-loop; other site 706587015383 ATP binding site [chemical binding]; other site 706587015384 Q-loop/lid; other site 706587015385 ABC transporter signature motif; other site 706587015386 Walker B; other site 706587015387 D-loop; other site 706587015388 H-loop/switch region; other site 706587015389 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 706587015390 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 706587015391 Walker A/P-loop; other site 706587015392 ATP binding site [chemical binding]; other site 706587015393 Q-loop/lid; other site 706587015394 ABC transporter signature motif; other site 706587015395 Walker B; other site 706587015396 D-loop; other site 706587015397 H-loop/switch region; other site 706587015398 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 706587015399 NMT1-like family; Region: NMT1_2; pfam13379 706587015400 Transcriptional regulators [Transcription]; Region: GntR; COG1802 706587015401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706587015402 DNA-binding site [nucleotide binding]; DNA binding site 706587015403 FCD domain; Region: FCD; pfam07729 706587015404 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 706587015405 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706587015406 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706587015407 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 706587015408 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 706587015409 active site residue [active] 706587015410 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 706587015411 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 706587015412 AIR carboxylase; Region: AIRC; smart01001 706587015413 Protein of unknown function DUF111; Region: DUF111; cl03398 706587015414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587015415 putative substrate translocation pore; other site 706587015416 Predicted transcriptional regulators [Transcription]; Region: COG1733 706587015417 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 706587015418 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 706587015419 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 706587015420 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 706587015421 dimer interaction site [polypeptide binding]; other site 706587015422 substrate-binding tunnel; other site 706587015423 active site 706587015424 catalytic site [active] 706587015425 substrate binding site [chemical binding]; other site 706587015426 phosphate acetyltransferase; Provisional; Region: PRK11890 706587015427 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 706587015428 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 706587015429 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 706587015430 NAD binding site [chemical binding]; other site 706587015431 homotetramer interface [polypeptide binding]; other site 706587015432 homodimer interface [polypeptide binding]; other site 706587015433 substrate binding site [chemical binding]; other site 706587015434 active site 706587015435 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 706587015436 homodimer interface [polypeptide binding]; other site 706587015437 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 706587015438 active site pocket [active] 706587015439 putative cation:proton antiport protein; Provisional; Region: PRK10669 706587015440 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 706587015441 TrkA-N domain; Region: TrkA_N; pfam02254 706587015442 TrkA-C domain; Region: TrkA_C; pfam02080 706587015443 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 706587015444 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 706587015445 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 706587015446 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 706587015447 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 706587015448 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 706587015449 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 706587015450 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 706587015451 trimer interface [polypeptide binding]; other site 706587015452 active site 706587015453 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 706587015454 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 706587015455 catalytic residues [active] 706587015456 catalytic nucleophile [active] 706587015457 Recombinase; Region: Recombinase; pfam07508 706587015458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706587015459 non-specific DNA binding site [nucleotide binding]; other site 706587015460 salt bridge; other site 706587015461 sequence-specific DNA binding site [nucleotide binding]; other site 706587015462 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 706587015463 polymerase nucleotide-binding site; other site 706587015464 DNA-binding residues [nucleotide binding]; DNA binding site 706587015465 nucleotide binding site [chemical binding]; other site 706587015466 primase nucleotide-binding site [nucleotide binding]; other site 706587015467 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 706587015468 AAA domain; Region: AAA_25; pfam13481 706587015469 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 706587015470 Walker A motif; other site 706587015471 ATP binding site [chemical binding]; other site 706587015472 Walker B motif; other site 706587015473 Helix-turn-helix domain; Region: HTH_17; pfam12728 706587015474 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 706587015475 active site 706587015476 Int/Topo IB signature motif; other site 706587015477 catalytic residues [active] 706587015478 DNA binding site [nucleotide binding] 706587015479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587015480 FeS/SAM binding site; other site 706587015481 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 706587015482 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 706587015483 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 706587015484 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706587015485 ATP binding site [chemical binding]; other site 706587015486 putative Mg++ binding site [ion binding]; other site 706587015487 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706587015488 nucleotide binding region [chemical binding]; other site 706587015489 ATP-binding site [chemical binding]; other site 706587015490 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 706587015491 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587015492 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 706587015493 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 706587015494 Walker A/P-loop; other site 706587015495 ATP binding site [chemical binding]; other site 706587015496 Q-loop/lid; other site 706587015497 ABC transporter signature motif; other site 706587015498 Walker B; other site 706587015499 D-loop; other site 706587015500 H-loop/switch region; other site 706587015501 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 706587015502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587015503 Walker A/P-loop; other site 706587015504 ATP binding site [chemical binding]; other site 706587015505 Q-loop/lid; other site 706587015506 ABC transporter signature motif; other site 706587015507 Walker B; other site 706587015508 D-loop; other site 706587015509 H-loop/switch region; other site 706587015510 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 706587015511 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 706587015512 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 706587015513 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 706587015514 FtsH Extracellular; Region: FtsH_ext; pfam06480 706587015515 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 706587015516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587015517 Walker A motif; other site 706587015518 ATP binding site [chemical binding]; other site 706587015519 Walker B motif; other site 706587015520 arginine finger; other site 706587015521 Peptidase family M41; Region: Peptidase_M41; pfam01434 706587015522 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 706587015523 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 706587015524 Ligand binding site; other site 706587015525 metal-binding site 706587015526 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 706587015527 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 706587015528 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 706587015529 UbiA prenyltransferase family; Region: UbiA; pfam01040 706587015530 elongation factor Tu; Reviewed; Region: PRK00049 706587015531 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 706587015532 G1 box; other site 706587015533 GEF interaction site [polypeptide binding]; other site 706587015534 GTP/Mg2+ binding site [chemical binding]; other site 706587015535 Switch I region; other site 706587015536 G2 box; other site 706587015537 G3 box; other site 706587015538 Switch II region; other site 706587015539 G4 box; other site 706587015540 G5 box; other site 706587015541 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 706587015542 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 706587015543 Antibiotic Binding Site [chemical binding]; other site 706587015544 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 706587015545 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 706587015546 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 706587015547 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 706587015548 putative homodimer interface [polypeptide binding]; other site 706587015549 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 706587015550 heterodimer interface [polypeptide binding]; other site 706587015551 homodimer interface [polypeptide binding]; other site 706587015552 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 706587015553 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 706587015554 23S rRNA interface [nucleotide binding]; other site 706587015555 L7/L12 interface [polypeptide binding]; other site 706587015556 putative thiostrepton binding site; other site 706587015557 L25 interface [polypeptide binding]; other site 706587015558 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 706587015559 mRNA/rRNA interface [nucleotide binding]; other site 706587015560 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 706587015561 23S rRNA interface [nucleotide binding]; other site 706587015562 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 706587015563 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 706587015564 core dimer interface [polypeptide binding]; other site 706587015565 peripheral dimer interface [polypeptide binding]; other site 706587015566 L10 interface [polypeptide binding]; other site 706587015567 L11 interface [polypeptide binding]; other site 706587015568 putative EF-Tu interaction site [polypeptide binding]; other site 706587015569 putative EF-G interaction site [polypeptide binding]; other site 706587015570 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 706587015571 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 706587015572 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 706587015573 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 706587015574 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 706587015575 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 706587015576 RPB1 interaction site [polypeptide binding]; other site 706587015577 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 706587015578 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 706587015579 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 706587015580 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 706587015581 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 706587015582 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 706587015583 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 706587015584 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 706587015585 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 706587015586 DNA binding site [nucleotide binding] 706587015587 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 706587015588 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 706587015589 S17 interaction site [polypeptide binding]; other site 706587015590 S8 interaction site; other site 706587015591 16S rRNA interaction site [nucleotide binding]; other site 706587015592 streptomycin interaction site [chemical binding]; other site 706587015593 23S rRNA interaction site [nucleotide binding]; other site 706587015594 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 706587015595 30S ribosomal protein S7; Validated; Region: PRK05302 706587015596 elongation factor G; Reviewed; Region: PRK00007 706587015597 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 706587015598 G1 box; other site 706587015599 putative GEF interaction site [polypeptide binding]; other site 706587015600 GTP/Mg2+ binding site [chemical binding]; other site 706587015601 Switch I region; other site 706587015602 G2 box; other site 706587015603 G3 box; other site 706587015604 Switch II region; other site 706587015605 G4 box; other site 706587015606 G5 box; other site 706587015607 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 706587015608 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 706587015609 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 706587015610 elongation factor Tu; Reviewed; Region: PRK00049 706587015611 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 706587015612 G1 box; other site 706587015613 GEF interaction site [polypeptide binding]; other site 706587015614 GTP/Mg2+ binding site [chemical binding]; other site 706587015615 Switch I region; other site 706587015616 G2 box; other site 706587015617 G3 box; other site 706587015618 Switch II region; other site 706587015619 G4 box; other site 706587015620 G5 box; other site 706587015621 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 706587015622 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 706587015623 Antibiotic Binding Site [chemical binding]; other site 706587015624 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 706587015625 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 706587015626 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 706587015627 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 706587015628 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 706587015629 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 706587015630 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 706587015631 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 706587015632 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 706587015633 putative translocon binding site; other site 706587015634 protein-rRNA interface [nucleotide binding]; other site 706587015635 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 706587015636 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 706587015637 G-X-X-G motif; other site 706587015638 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 706587015639 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 706587015640 23S rRNA interface [nucleotide binding]; other site 706587015641 5S rRNA interface [nucleotide binding]; other site 706587015642 putative antibiotic binding site [chemical binding]; other site 706587015643 L25 interface [polypeptide binding]; other site 706587015644 L27 interface [polypeptide binding]; other site 706587015645 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 706587015646 putative translocon interaction site; other site 706587015647 23S rRNA interface [nucleotide binding]; other site 706587015648 signal recognition particle (SRP54) interaction site; other site 706587015649 L23 interface [polypeptide binding]; other site 706587015650 trigger factor interaction site; other site 706587015651 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 706587015652 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 706587015653 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 706587015654 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 706587015655 RNA binding site [nucleotide binding]; other site 706587015656 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 706587015657 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 706587015658 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 706587015659 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 706587015660 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 706587015661 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 706587015662 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 706587015663 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 706587015664 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 706587015665 23S rRNA interface [nucleotide binding]; other site 706587015666 L21e interface [polypeptide binding]; other site 706587015667 5S rRNA interface [nucleotide binding]; other site 706587015668 L27 interface [polypeptide binding]; other site 706587015669 L5 interface [polypeptide binding]; other site 706587015670 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 706587015671 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 706587015672 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 706587015673 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 706587015674 23S rRNA binding site [nucleotide binding]; other site 706587015675 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 706587015676 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 706587015677 SecY translocase; Region: SecY; pfam00344 706587015678 adenylate kinase; Reviewed; Region: adk; PRK00279 706587015679 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 706587015680 AMP-binding site [chemical binding]; other site 706587015681 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 706587015682 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 706587015683 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 706587015684 30S ribosomal protein S13; Region: bact_S13; TIGR03631 706587015685 30S ribosomal protein S11; Validated; Region: PRK05309 706587015686 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 706587015687 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 706587015688 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 706587015689 RNA binding surface [nucleotide binding]; other site 706587015690 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 706587015691 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 706587015692 alphaNTD homodimer interface [polypeptide binding]; other site 706587015693 alphaNTD - beta interaction site [polypeptide binding]; other site 706587015694 alphaNTD - beta' interaction site [polypeptide binding]; other site 706587015695 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 706587015696 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 706587015697 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 706587015698 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 706587015699 Walker A/P-loop; other site 706587015700 ATP binding site [chemical binding]; other site 706587015701 Q-loop/lid; other site 706587015702 ABC transporter signature motif; other site 706587015703 Walker B; other site 706587015704 D-loop; other site 706587015705 H-loop/switch region; other site 706587015706 Septum formation initiator; Region: DivIC; pfam04977 706587015707 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 706587015708 Competence protein A; Region: Competence_A; pfam11104 706587015709 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 706587015710 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 706587015711 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 706587015712 Pilus assembly protein, PilO; Region: PilO; cl01234 706587015713 Pilus assembly protein, PilP; Region: PilP; pfam04351 706587015714 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 706587015715 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 706587015716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587015717 Mg2+ binding site [ion binding]; other site 706587015718 G-X-G motif; other site 706587015719 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 706587015720 anchoring element; other site 706587015721 dimer interface [polypeptide binding]; other site 706587015722 ATP binding site [chemical binding]; other site 706587015723 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 706587015724 active site 706587015725 putative metal-binding site [ion binding]; other site 706587015726 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 706587015727 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 706587015728 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 706587015729 CAP-like domain; other site 706587015730 active site 706587015731 primary dimer interface [polypeptide binding]; other site 706587015732 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 706587015733 PQQ-like domain; Region: PQQ_2; pfam13360 706587015734 Trp docking motif [polypeptide binding]; other site 706587015735 active site 706587015736 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 706587015737 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 706587015738 substrate-cofactor binding pocket; other site 706587015739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587015740 catalytic residue [active] 706587015741 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 706587015742 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 706587015743 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 706587015744 SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249 706587015745 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 706587015746 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 706587015747 Family description; Region: VCBS; pfam13517 706587015748 Family description; Region: VCBS; pfam13517 706587015749 Family description; Region: VCBS; pfam13517 706587015750 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 706587015751 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 706587015752 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587015753 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 706587015754 acyl-activating enzyme (AAE) consensus motif; other site 706587015755 acyl-activating enzyme (AAE) consensus motif; other site 706587015756 putative AMP binding site [chemical binding]; other site 706587015757 putative active site [active] 706587015758 putative CoA binding site [chemical binding]; other site 706587015759 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 706587015760 CoenzymeA binding site [chemical binding]; other site 706587015761 subunit interaction site [polypeptide binding]; other site 706587015762 PHB binding site; other site 706587015763 Uncharacterized conserved protein [Function unknown]; Region: COG2006 706587015764 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 706587015765 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 706587015766 putative glycosyl transferase; Provisional; Region: PRK10307 706587015767 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 706587015768 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 706587015769 Bacterial sugar transferase; Region: Bac_transf; pfam02397 706587015770 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 706587015771 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 706587015772 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 706587015773 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 706587015774 putative acyl-acceptor binding pocket; other site 706587015775 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 706587015776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015777 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587015778 putative active site [active] 706587015779 heme pocket [chemical binding]; other site 706587015780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587015781 dimer interface [polypeptide binding]; other site 706587015782 phosphorylation site [posttranslational modification] 706587015783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587015784 ATP binding site [chemical binding]; other site 706587015785 Mg2+ binding site [ion binding]; other site 706587015786 G-X-G motif; other site 706587015787 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 706587015788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587015789 active site 706587015790 phosphorylation site [posttranslational modification] 706587015791 intermolecular recognition site; other site 706587015792 dimerization interface [polypeptide binding]; other site 706587015793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587015794 Walker A motif; other site 706587015795 ATP binding site [chemical binding]; other site 706587015796 Walker B motif; other site 706587015797 arginine finger; other site 706587015798 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587015799 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 706587015800 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587015801 acyl-activating enzyme (AAE) consensus motif; other site 706587015802 AMP binding site [chemical binding]; other site 706587015803 active site 706587015804 CoA binding site [chemical binding]; other site 706587015805 FOG: CBS domain [General function prediction only]; Region: COG0517 706587015806 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 706587015807 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587015808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587015809 ATP binding site [chemical binding]; other site 706587015810 Mg2+ binding site [ion binding]; other site 706587015811 G-X-G motif; other site 706587015812 Response regulator receiver domain; Region: Response_reg; pfam00072 706587015813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587015814 active site 706587015815 phosphorylation site [posttranslational modification] 706587015816 intermolecular recognition site; other site 706587015817 dimerization interface [polypeptide binding]; other site 706587015818 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 706587015819 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 706587015820 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 706587015821 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 706587015822 heme-binding residues [chemical binding]; other site 706587015823 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 706587015824 heme-binding residues [chemical binding]; other site 706587015825 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 706587015826 heme-binding residues [chemical binding]; other site 706587015827 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 706587015828 heme-binding residues [chemical binding]; other site 706587015829 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587015830 Cysteine-rich domain; Region: CCG; pfam02754 706587015831 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 706587015832 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587015833 dimerization interface [polypeptide binding]; other site 706587015834 PAS domain; Region: PAS_9; pfam13426 706587015835 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 706587015836 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015837 putative active site [active] 706587015838 heme pocket [chemical binding]; other site 706587015839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 706587015840 dimer interface [polypeptide binding]; other site 706587015841 phosphorylation site [posttranslational modification] 706587015842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587015843 ATP binding site [chemical binding]; other site 706587015844 Mg2+ binding site [ion binding]; other site 706587015845 G-X-G motif; other site 706587015846 Response regulator receiver domain; Region: Response_reg; pfam00072 706587015847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587015848 active site 706587015849 phosphorylation site [posttranslational modification] 706587015850 intermolecular recognition site; other site 706587015851 dimerization interface [polypeptide binding]; other site 706587015852 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587015853 PAS domain; Region: PAS_9; pfam13426 706587015854 putative active site [active] 706587015855 heme pocket [chemical binding]; other site 706587015856 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587015857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587015858 Walker A motif; other site 706587015859 ATP binding site [chemical binding]; other site 706587015860 Walker B motif; other site 706587015861 arginine finger; other site 706587015862 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587015863 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706587015864 Ligand Binding Site [chemical binding]; other site 706587015865 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587015866 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587015867 Selenophosphate synthetase-related proteins [General function prediction only]; Region: COG2144 706587015868 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 706587015869 dimerization interface [polypeptide binding]; other site 706587015870 putative ATP binding site [chemical binding]; other site 706587015871 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 706587015872 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587015873 FeS/SAM binding site; other site 706587015874 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 706587015875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587015876 Coenzyme A binding pocket [chemical binding]; other site 706587015877 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 706587015878 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 706587015879 Walker A/P-loop; other site 706587015880 ATP binding site [chemical binding]; other site 706587015881 Q-loop/lid; other site 706587015882 ABC transporter signature motif; other site 706587015883 Walker B; other site 706587015884 D-loop; other site 706587015885 H-loop/switch region; other site 706587015886 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 706587015887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587015888 dimer interface [polypeptide binding]; other site 706587015889 conserved gate region; other site 706587015890 putative PBP binding loops; other site 706587015891 ABC-ATPase subunit interface; other site 706587015892 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 706587015893 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706587015894 substrate binding pocket [chemical binding]; other site 706587015895 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 706587015896 membrane-bound complex binding site; other site 706587015897 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587015898 Cysteine-rich domain; Region: CCG; pfam02754 706587015899 Cysteine-rich domain; Region: CCG; pfam02754 706587015900 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 706587015901 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 706587015902 heme-binding residues [chemical binding]; other site 706587015903 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 706587015904 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 706587015905 heme-binding residues [chemical binding]; other site 706587015906 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 706587015907 conserved cys residue [active] 706587015908 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 706587015909 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 706587015910 Transcriptional regulators [Transcription]; Region: FadR; COG2186 706587015911 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706587015912 DNA-binding site [nucleotide binding]; DNA binding site 706587015913 FCD domain; Region: FCD; pfam07729 706587015914 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 706587015915 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 706587015916 tetrameric interface [polypeptide binding]; other site 706587015917 NAD binding site [chemical binding]; other site 706587015918 catalytic residues [active] 706587015919 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 706587015920 FAD binding domain; Region: FAD_binding_4; pfam01565 706587015921 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706587015922 Cysteine-rich domain; Region: CCG; pfam02754 706587015923 Cysteine-rich domain; Region: CCG; pfam02754 706587015924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587015925 D-galactonate transporter; Region: 2A0114; TIGR00893 706587015926 putative substrate translocation pore; other site 706587015927 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 706587015928 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 706587015929 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family [Amino acid transport and metabolism]; Region: SpeB; COG0010 706587015930 active site 706587015931 metal binding site [ion binding]; metal-binding site 706587015932 Transcriptional regulators [Transcription]; Region: FadR; COG2186 706587015933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706587015934 DNA-binding site [nucleotide binding]; DNA binding site 706587015935 FCD domain; Region: FCD; pfam07729 706587015936 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 706587015937 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 706587015938 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 706587015939 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587015940 catalytic loop [active] 706587015941 iron binding site [ion binding]; other site 706587015942 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587015943 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 706587015944 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587015945 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587015946 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706587015947 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 706587015948 ligand binding site [chemical binding]; other site 706587015949 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587015950 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587015951 Walker A/P-loop; other site 706587015952 ATP binding site [chemical binding]; other site 706587015953 Q-loop/lid; other site 706587015954 ABC transporter signature motif; other site 706587015955 Walker B; other site 706587015956 D-loop; other site 706587015957 H-loop/switch region; other site 706587015958 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587015959 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587015960 Walker A/P-loop; other site 706587015961 ATP binding site [chemical binding]; other site 706587015962 Q-loop/lid; other site 706587015963 ABC transporter signature motif; other site 706587015964 Walker B; other site 706587015965 D-loop; other site 706587015966 H-loop/switch region; other site 706587015967 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706587015968 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587015969 TM-ABC transporter signature motif; other site 706587015970 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587015971 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587015972 TM-ABC transporter signature motif; other site 706587015973 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 706587015974 glyoxylate reductase; Reviewed; Region: PRK13243 706587015975 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 706587015976 dimerization interface [polypeptide binding]; other site 706587015977 ligand binding site [chemical binding]; other site 706587015978 NADP binding site [chemical binding]; other site 706587015979 catalytic site [active] 706587015980 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 706587015981 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 706587015982 Protein of unknown function, DUF486; Region: DUF486; pfam04342 706587015983 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 706587015984 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 706587015985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587015986 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 706587015987 Walker A/P-loop; other site 706587015988 ATP binding site [chemical binding]; other site 706587015989 Q-loop/lid; other site 706587015990 ABC transporter signature motif; other site 706587015991 Walker B; other site 706587015992 D-loop; other site 706587015993 H-loop/switch region; other site 706587015994 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 706587015995 Walker A/P-loop; other site 706587015996 ATP binding site [chemical binding]; other site 706587015997 Q-loop/lid; other site 706587015998 ABC transporter signature motif; other site 706587015999 Walker B; other site 706587016000 D-loop; other site 706587016001 H-loop/switch region; other site 706587016002 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 706587016003 Dynamin family; Region: Dynamin_N; pfam00350 706587016004 G1 box; other site 706587016005 GTP/Mg2+ binding site [chemical binding]; other site 706587016006 G2 box; other site 706587016007 Switch I region; other site 706587016008 G3 box; other site 706587016009 Switch II region; other site 706587016010 G4 box; other site 706587016011 G5 box; other site 706587016012 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 706587016013 Sel1-like repeats; Region: SEL1; smart00671 706587016014 Sel1-like repeats; Region: SEL1; smart00671 706587016015 tetrathionate reductase subunit A; Provisional; Region: PRK14991 706587016016 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 706587016017 putative [Fe4-S4] binding site [ion binding]; other site 706587016018 putative molybdopterin cofactor binding site [chemical binding]; other site 706587016019 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 706587016020 putative molybdopterin cofactor binding site; other site 706587016021 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 706587016022 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 706587016023 4Fe-4S binding domain; Region: Fer4_6; pfam12837 706587016024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 706587016025 active site 706587016026 phosphorylation site [posttranslational modification] 706587016027 intermolecular recognition site; other site 706587016028 dimerization interface [polypeptide binding]; other site 706587016029 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587016030 dimerization interface [polypeptide binding]; other site 706587016031 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706587016032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587016033 Walker A motif; other site 706587016034 ATP binding site [chemical binding]; other site 706587016035 Walker B motif; other site 706587016036 arginine finger; other site 706587016037 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587016038 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 706587016039 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 706587016040 Low molecular weight phosphatase family; Region: LMWPc; cd00115 706587016041 active site 706587016042 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 706587016043 arsenical-resistance protein; Region: acr3; TIGR00832 706587016044 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706587016045 dimerization interface [polypeptide binding]; other site 706587016046 putative DNA binding site [nucleotide binding]; other site 706587016047 putative Zn2+ binding site [ion binding]; other site 706587016048 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 706587016049 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 706587016050 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 706587016051 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 706587016052 catalytic residues [active] 706587016053 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 706587016054 Predicted permease; Region: DUF318; cl17795 706587016055 Predicted permease; Region: DUF318; cl17795 706587016056 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706587016057 dimerization interface [polypeptide binding]; other site 706587016058 putative DNA binding site [nucleotide binding]; other site 706587016059 putative Zn2+ binding site [ion binding]; other site 706587016060 Transcriptional regulators [Transcription]; Region: MarR; COG1846 706587016061 MarR family; Region: MarR_2; pfam12802 706587016062 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706587016063 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706587016064 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587016065 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 706587016066 Domain of unknown function DUF302; Region: DUF302; cl01364 706587016067 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 706587016068 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706587016069 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706587016070 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 706587016071 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706587016072 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 706587016073 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 706587016074 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 706587016075 Transcriptional regulators [Transcription]; Region: MarR; COG1846 706587016076 MarR family; Region: MarR_2; pfam12802 706587016077 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 706587016078 CoenzymeA binding site [chemical binding]; other site 706587016079 subunit interaction site [polypeptide binding]; other site 706587016080 PHB binding site; other site 706587016081 4Fe-4S binding domain; Region: Fer4; pfam00037 706587016082 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 706587016083 SCP-2 sterol transfer family; Region: SCP2; pfam02036 706587016084 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 706587016085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587016086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587016087 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 706587016088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587016089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587016090 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 706587016091 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 706587016092 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 706587016093 acyl-activating enzyme (AAE) consensus motif; other site 706587016094 putative AMP binding site [chemical binding]; other site 706587016095 putative active site [active] 706587016096 putative CoA binding site [chemical binding]; other site 706587016097 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 706587016098 dimer interaction site [polypeptide binding]; other site 706587016099 substrate-binding tunnel; other site 706587016100 active site 706587016101 catalytic site [active] 706587016102 substrate binding site [chemical binding]; other site 706587016103 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 706587016104 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706587016105 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 706587016106 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 706587016107 isovaleryl-CoA dehydrogenase; Region: PLN02519 706587016108 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587016109 active site 706587016110 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 706587016111 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 706587016112 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706587016113 active site 706587016114 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 706587016115 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 706587016116 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587016117 acyl-activating enzyme (AAE) consensus motif; other site 706587016118 AMP binding site [chemical binding]; other site 706587016119 active site 706587016120 CoA binding site [chemical binding]; other site 706587016121 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 706587016122 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 706587016123 DUF35 OB-fold domain; Region: DUF35; pfam01796 706587016124 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 706587016125 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 706587016126 active site 706587016127 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 706587016128 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 706587016129 active site 706587016130 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 706587016131 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 706587016132 DUF35 OB-fold domain; Region: DUF35; pfam01796 706587016133 putative acyltransferase; Provisional; Region: PRK05790 706587016134 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 706587016135 dimer interface [polypeptide binding]; other site 706587016136 active site 706587016137 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 706587016138 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587016139 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 706587016140 acyl-activating enzyme (AAE) consensus motif; other site 706587016141 putative AMP binding site [chemical binding]; other site 706587016142 putative active site [active] 706587016143 putative CoA binding site [chemical binding]; other site 706587016144 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 706587016145 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 706587016146 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 706587016147 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 706587016148 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706587016149 substrate binding site [chemical binding]; other site 706587016150 oxyanion hole (OAH) forming residues; other site 706587016151 trimer interface [polypeptide binding]; other site 706587016152 HPP family; Region: HPP; pfam04982 706587016153 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 706587016154 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 706587016155 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 706587016156 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 706587016157 B12 binding site [chemical binding]; other site 706587016158 cobalt ligand [ion binding]; other site 706587016159 tetrahydromethanopterin S-methyltransferase subunit H; Provisional; Region: PRK00979 706587016160 Tetrahydromethanopterin S-methyltransferase, subunit H [Coenzyme metabolism]; Region: MtrH; cl15798 706587016161 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 706587016162 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706587016163 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706587016164 DNA binding residues [nucleotide binding] 706587016165 NMT1-like family; Region: NMT1_2; pfam13379 706587016166 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 706587016167 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 706587016168 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 706587016169 Predicted amidohydrolase [General function prediction only]; Region: COG0388 706587016170 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 706587016171 putative active site [active] 706587016172 catalytic triad [active] 706587016173 putative dimer interface [polypeptide binding]; other site 706587016174 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 706587016175 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706587016176 Helix-turn-helix domain; Region: HTH_17; pfam12728 706587016177 HPP family; Region: HPP; pfam04982 706587016178 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 706587016179 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 706587016180 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 706587016181 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 706587016182 B12 binding site [chemical binding]; other site 706587016183 cobalt ligand [ion binding]; other site 706587016184 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 706587016185 tetrahydromethanopterin S-methyltransferase subunit H; Provisional; Region: PRK00979 706587016186 Tetrahydromethanopterin S-methyltransferase, subunit H [Coenzyme metabolism]; Region: MtrH; cl15798 706587016187 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 706587016188 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 706587016189 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 706587016190 Walker A/P-loop; other site 706587016191 ATP binding site [chemical binding]; other site 706587016192 Q-loop/lid; other site 706587016193 ABC transporter signature motif; other site 706587016194 Walker B; other site 706587016195 D-loop; other site 706587016196 H-loop/switch region; other site 706587016197 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 706587016198 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706587016199 N-terminal plug; other site 706587016200 ligand-binding site [chemical binding]; other site 706587016201 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 706587016202 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706587016203 N-terminal plug; other site 706587016204 ligand-binding site [chemical binding]; other site 706587016205 macrolide transporter subunit MacA; Provisional; Region: PRK11578 706587016206 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587016207 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 706587016208 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 706587016209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587016210 Walker A motif; other site 706587016211 ATP binding site [chemical binding]; other site 706587016212 Walker B motif; other site 706587016213 arginine finger; other site 706587016214 Protein of unknown function (DUF444); Region: DUF444; cl17371 706587016215 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 706587016216 metal ion-dependent adhesion site (MIDAS); other site 706587016217 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 706587016218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587016219 Walker A motif; other site 706587016220 ATP binding site [chemical binding]; other site 706587016221 Walker B motif; other site 706587016222 arginine finger; other site 706587016223 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 706587016224 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 706587016225 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 706587016226 ABC-2 type transporter; Region: ABC2_membrane; cl17235 706587016227 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 706587016228 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 706587016229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706587016230 Walker A/P-loop; other site 706587016231 ATP binding site [chemical binding]; other site 706587016232 Q-loop/lid; other site 706587016233 ABC transporter signature motif; other site 706587016234 Walker B; other site 706587016235 D-loop; other site 706587016236 H-loop/switch region; other site 706587016237 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 706587016238 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 706587016239 Walker A/P-loop; other site 706587016240 ATP binding site [chemical binding]; other site 706587016241 Q-loop/lid; other site 706587016242 ABC transporter signature motif; other site 706587016243 Walker B; other site 706587016244 D-loop; other site 706587016245 H-loop/switch region; other site 706587016246 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 706587016247 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706587016248 ABC-ATPase subunit interface; other site 706587016249 dimer interface [polypeptide binding]; other site 706587016250 putative PBP binding regions; other site 706587016251 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 706587016252 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 706587016253 intersubunit interface [polypeptide binding]; other site 706587016254 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 706587016255 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 706587016256 intersubunit interface [polypeptide binding]; other site 706587016257 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 706587016258 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 706587016259 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 706587016260 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587016261 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 706587016262 FtsX-like permease family; Region: FtsX; pfam02687 706587016263 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 706587016264 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 706587016265 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 706587016266 active site 706587016267 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 706587016268 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706587016269 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 706587016270 acyl-activating enzyme (AAE) consensus motif; other site 706587016271 acyl-activating enzyme (AAE) consensus motif; other site 706587016272 putative AMP binding site [chemical binding]; other site 706587016273 putative active site [active] 706587016274 putative CoA binding site [chemical binding]; other site 706587016275 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 706587016276 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 706587016277 DNA binding residues [nucleotide binding] 706587016278 putative dimer interface [polypeptide binding]; other site 706587016279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587016280 binding surface 706587016281 TPR motif; other site 706587016282 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587016283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706587016284 binding surface 706587016285 TPR motif; other site 706587016286 Tetratricopeptide repeat; Region: TPR_12; pfam13424 706587016287 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587016288 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587016289 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587016290 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587016291 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587016292 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 706587016293 FOG: CBS domain [General function prediction only]; Region: COG0517 706587016294 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 706587016295 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 706587016296 FOG: CBS domain [General function prediction only]; Region: COG0517 706587016297 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 706587016298 FOG: CBS domain [General function prediction only]; Region: COG0517 706587016299 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 706587016300 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 706587016301 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 706587016302 Nucleotide-binding sites [chemical binding]; other site 706587016303 Walker A motif; other site 706587016304 Switch I region of nucleotide binding site; other site 706587016305 Fe4S4 binding sites [ion binding]; other site 706587016306 Switch II region of nucleotide binding site; other site 706587016307 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 706587016308 Nitrogen regulatory protein P-II; Region: P-II; smart00938 706587016309 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 706587016310 Nitrogen regulatory protein P-II; Region: P-II; smart00938 706587016311 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 706587016312 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 706587016313 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 706587016314 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 706587016315 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 706587016316 dimer interface [polypeptide binding]; other site 706587016317 [2Fe-2S] cluster binding site [ion binding]; other site 706587016318 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 706587016319 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 706587016320 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 706587016321 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 706587016322 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 706587016323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706587016324 FeS/SAM binding site; other site 706587016325 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 706587016326 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587016327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587016328 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587016329 Nif-specific regulatory protein; Region: nifA; TIGR01817 706587016330 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 706587016331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587016332 Walker A motif; other site 706587016333 ATP binding site [chemical binding]; other site 706587016334 Walker B motif; other site 706587016335 arginine finger; other site 706587016336 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587016337 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 706587016338 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706587016339 catalytic loop [active] 706587016340 iron binding site [ion binding]; other site 706587016341 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 706587016342 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 706587016343 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 706587016344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706587016345 putative substrate translocation pore; other site 706587016346 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 706587016347 substrate binding pocket [chemical binding]; other site 706587016348 dimer interface [polypeptide binding]; other site 706587016349 inhibitor binding site; inhibition site 706587016350 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 706587016351 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 706587016352 B12 binding site [chemical binding]; other site 706587016353 Nif-specific regulatory protein; Region: nifA; TIGR01817 706587016354 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 706587016355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587016356 Walker A motif; other site 706587016357 ATP binding site [chemical binding]; other site 706587016358 Walker B motif; other site 706587016359 arginine finger; other site 706587016360 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706587016361 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 706587016362 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 706587016363 phosphodiesterase YaeI; Provisional; Region: PRK11340 706587016364 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 706587016365 putative active site [active] 706587016366 putative metal binding site [ion binding]; other site 706587016367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706587016368 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 706587016369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587016370 S-adenosylmethionine binding site [chemical binding]; other site 706587016371 macrolide transporter subunit MacA; Provisional; Region: PRK11578 706587016372 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 706587016373 HlyD family secretion protein; Region: HlyD_3; pfam13437 706587016374 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 706587016375 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 706587016376 Walker A/P-loop; other site 706587016377 ATP binding site [chemical binding]; other site 706587016378 Q-loop/lid; other site 706587016379 ABC transporter signature motif; other site 706587016380 Walker B; other site 706587016381 D-loop; other site 706587016382 H-loop/switch region; other site 706587016383 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587016384 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 706587016385 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587016386 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 706587016387 FtsX-like permease family; Region: FtsX; pfam02687 706587016388 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 706587016389 FAD binding domain; Region: FAD_binding_4; pfam01565 706587016390 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 706587016391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587016392 S-adenosylmethionine binding site [chemical binding]; other site 706587016393 Putative Fe-S cluster; Region: FeS; cl17515 706587016394 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 706587016395 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970 706587016396 putative active site [active] 706587016397 putative metal binding site [ion binding]; other site 706587016398 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 706587016399 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970 706587016400 putative active site [active] 706587016401 putative metal binding site [ion binding]; other site 706587016402 Transposase; Region: DEDD_Tnp_IS110; pfam01548 706587016403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 706587016404 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 706587016405 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 706587016406 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 706587016407 putative RNA binding site [nucleotide binding]; other site 706587016408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587016409 S-adenosylmethionine binding site [chemical binding]; other site 706587016410 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 706587016411 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 706587016412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587016413 dimer interface [polypeptide binding]; other site 706587016414 conserved gate region; other site 706587016415 putative PBP binding loops; other site 706587016416 ABC-ATPase subunit interface; other site 706587016417 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 706587016418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587016419 dimer interface [polypeptide binding]; other site 706587016420 conserved gate region; other site 706587016421 putative PBP binding loops; other site 706587016422 ABC-ATPase subunit interface; other site 706587016423 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 706587016424 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 706587016425 peptide binding site [polypeptide binding]; other site 706587016426 seryl-tRNA synthetase; Provisional; Region: PRK05431 706587016427 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 706587016428 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 706587016429 dimer interface [polypeptide binding]; other site 706587016430 active site 706587016431 motif 1; other site 706587016432 motif 2; other site 706587016433 motif 3; other site 706587016434 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 706587016435 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 706587016436 active site 706587016437 cosubstrate binding site; other site 706587016438 substrate binding site [chemical binding]; other site 706587016439 catalytic site [active] 706587016440 Predicted thioesterase [General function prediction only]; Region: COG5496 706587016441 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706587016442 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706587016443 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 706587016444 dimerization interface [polypeptide binding]; other site 706587016445 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 706587016446 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 706587016447 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 706587016448 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 706587016449 MOFRL family; Region: MOFRL; pfam05161 706587016450 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 706587016451 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706587016452 dimerization interface [polypeptide binding]; other site 706587016453 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 706587016454 cyclase homology domain; Region: CHD; cd07302 706587016455 nucleotidyl binding site; other site 706587016456 metal binding site [ion binding]; metal-binding site 706587016457 dimer interface [polypeptide binding]; other site 706587016458 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 706587016459 ATP binding site [chemical binding]; other site 706587016460 active site 706587016461 substrate binding site [chemical binding]; other site 706587016462 CTP synthetase; Validated; Region: pyrG; PRK05380 706587016463 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 706587016464 Catalytic site [active] 706587016465 active site 706587016466 UTP binding site [chemical binding]; other site 706587016467 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 706587016468 active site 706587016469 putative oxyanion hole; other site 706587016470 catalytic triad [active] 706587016471 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 706587016472 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 706587016473 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 706587016474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706587016475 active site 706587016476 motif I; other site 706587016477 motif II; other site 706587016478 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 706587016479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 706587016480 OstA-like protein; Region: OstA; pfam03968 706587016481 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 706587016482 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 706587016483 Walker A/P-loop; other site 706587016484 ATP binding site [chemical binding]; other site 706587016485 Q-loop/lid; other site 706587016486 ABC transporter signature motif; other site 706587016487 Walker B; other site 706587016488 D-loop; other site 706587016489 H-loop/switch region; other site 706587016490 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 706587016491 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 706587016492 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 706587016493 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 706587016494 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 706587016495 30S subunit binding site; other site 706587016496 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 706587016497 active site 706587016498 phosphorylation site [posttranslational modification] 706587016499 Fumarase C-terminus; Region: Fumerase_C; cl00795 706587016500 fumarate hydratase; Provisional; Region: PRK06246 706587016501 Response regulator receiver domain; Region: Response_reg; pfam00072 706587016502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587016503 active site 706587016504 phosphorylation site [posttranslational modification] 706587016505 intermolecular recognition site; other site 706587016506 dimerization interface [polypeptide binding]; other site 706587016507 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 706587016508 Histidine kinase; Region: HisKA_2; pfam07568 706587016509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587016510 ATP binding site [chemical binding]; other site 706587016511 Mg2+ binding site [ion binding]; other site 706587016512 G-X-G motif; other site 706587016513 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 706587016514 Catalytic domain of Protein Kinases; Region: PKc; cd00180 706587016515 active site 706587016516 ATP binding site [chemical binding]; other site 706587016517 substrate binding site [chemical binding]; other site 706587016518 activation loop (A-loop); other site 706587016519 AAA ATPase domain; Region: AAA_16; pfam13191 706587016520 Predicted ATPase [General function prediction only]; Region: COG3899 706587016521 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706587016522 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 706587016523 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706587016524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706587016525 dimer interface [polypeptide binding]; other site 706587016526 phosphorylation site [posttranslational modification] 706587016527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706587016528 ATP binding site [chemical binding]; other site 706587016529 Mg2+ binding site [ion binding]; other site 706587016530 G-X-G motif; other site 706587016531 Response regulator receiver domain; Region: Response_reg; pfam00072 706587016532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706587016533 active site 706587016534 phosphorylation site [posttranslational modification] 706587016535 intermolecular recognition site; other site 706587016536 dimerization interface [polypeptide binding]; other site 706587016537 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 706587016538 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587016539 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706587016540 TM-ABC transporter signature motif; other site 706587016541 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706587016542 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706587016543 TM-ABC transporter signature motif; other site 706587016544 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 706587016545 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706587016546 Walker A/P-loop; other site 706587016547 ATP binding site [chemical binding]; other site 706587016548 Q-loop/lid; other site 706587016549 ABC transporter signature motif; other site 706587016550 Walker B; other site 706587016551 D-loop; other site 706587016552 H-loop/switch region; other site 706587016553 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 706587016554 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706587016555 Walker A/P-loop; other site 706587016556 ATP binding site [chemical binding]; other site 706587016557 Q-loop/lid; other site 706587016558 ABC transporter signature motif; other site 706587016559 Walker B; other site 706587016560 D-loop; other site 706587016561 H-loop/switch region; other site 706587016562 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587016563 PBP superfamily domain; Region: PBP_like_2; cl17296 706587016564 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 706587016565 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 706587016566 RNA/DNA hybrid binding site [nucleotide binding]; other site 706587016567 active site 706587016568 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 706587016569 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 706587016570 active site 706587016571 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 706587016572 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706587016573 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 706587016574 Methyltransferase domain; Region: Methyltransf_24; pfam13578 706587016575 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 706587016576 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 706587016577 conserved cys residue [active] 706587016578 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 706587016579 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 706587016580 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 706587016581 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706587016582 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 706587016583 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 706587016584 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 706587016585 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 706587016586 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 706587016587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706587016588 Coenzyme A binding pocket [chemical binding]; other site 706587016589 phosphate acetyltransferase; Reviewed; Region: PRK05632 706587016590 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587016591 DRTGG domain; Region: DRTGG; pfam07085 706587016592 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 706587016593 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 706587016594 propionate/acetate kinase; Provisional; Region: PRK12379 706587016595 PAS domain S-box; Region: sensory_box; TIGR00229 706587016596 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587016597 putative active site [active] 706587016598 heme pocket [chemical binding]; other site 706587016599 PAS domain S-box; Region: sensory_box; TIGR00229 706587016600 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706587016601 putative active site [active] 706587016602 heme pocket [chemical binding]; other site 706587016603 PAS fold; Region: PAS_4; pfam08448 706587016604 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 706587016605 putative active site [active] 706587016606 heme pocket [chemical binding]; other site 706587016607 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 706587016608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706587016609 Walker A motif; other site 706587016610 ATP binding site [chemical binding]; other site 706587016611 Walker B motif; other site 706587016612 arginine finger; other site 706587016613 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587016614 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587016615 DDE superfamily endonuclease; Region: DDE_5; cl17874 706587016616 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 706587016617 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 706587016618 GTP binding site; other site 706587016619 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 706587016620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587016621 S-adenosylmethionine binding site [chemical binding]; other site 706587016622 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 706587016623 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 706587016624 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 706587016625 putative active site [active] 706587016626 TRAM domain; Region: TRAM; cl01282 706587016627 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 706587016628 FAD binding site [chemical binding]; other site 706587016629 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 706587016630 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 706587016631 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 706587016632 homotrimer interface [polypeptide binding]; other site 706587016633 Walker A motif; other site 706587016634 GTP binding site [chemical binding]; other site 706587016635 Walker B motif; other site 706587016636 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 706587016637 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 706587016638 putative dimer interface [polypeptide binding]; other site 706587016639 active site pocket [active] 706587016640 putative cataytic base [active] 706587016641 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 706587016642 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706587016643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587016644 homodimer interface [polypeptide binding]; other site 706587016645 catalytic residue [active] 706587016646 cobyric acid synthase; Provisional; Region: PRK00784 706587016647 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587016648 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587016649 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 706587016650 catalytic triad [active] 706587016651 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 706587016652 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 706587016653 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 706587016654 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 706587016655 catalytic triad [active] 706587016656 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 706587016657 Precorrin-8X methylmutase; Region: CbiC; pfam02570 706587016658 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 706587016659 putative active site [active] 706587016660 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 706587016661 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 706587016662 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 706587016663 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 706587016664 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 706587016665 Walker A/P-loop; other site 706587016666 ATP binding site [chemical binding]; other site 706587016667 Q-loop/lid; other site 706587016668 ABC transporter signature motif; other site 706587016669 Walker B; other site 706587016670 D-loop; other site 706587016671 H-loop/switch region; other site 706587016672 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 706587016673 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 706587016674 active site 706587016675 putative homodimer interface [polypeptide binding]; other site 706587016676 SAM binding site [chemical binding]; other site 706587016677 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 706587016678 active site 706587016679 SAM binding site [chemical binding]; other site 706587016680 homodimer interface [polypeptide binding]; other site 706587016681 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 706587016682 active site 706587016683 SAM binding site [chemical binding]; other site 706587016684 homodimer interface [polypeptide binding]; other site 706587016685 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 706587016686 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 706587016687 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 706587016688 active site 706587016689 SAM binding site [chemical binding]; other site 706587016690 homodimer interface [polypeptide binding]; other site 706587016691 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 706587016692 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 706587016693 SCP-2 sterol transfer family; Region: SCP2; pfam02036 706587016694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706587016695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706587016696 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 706587016697 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 706587016698 homodimer interface [polypeptide binding]; other site 706587016699 substrate-cofactor binding pocket; other site 706587016700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706587016701 catalytic residue [active] 706587016702 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 706587016703 active site 706587016704 dimerization interface [polypeptide binding]; other site 706587016705 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 706587016706 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 706587016707 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587016708 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 706587016709 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587016710 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 706587016711 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 706587016712 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 706587016713 PhoU domain; Region: PhoU; pfam01895 706587016714 PhoU domain; Region: PhoU; pfam01895 706587016715 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 706587016716 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 706587016717 GIY-YIG motif/motif A; other site 706587016718 active site 706587016719 catalytic site [active] 706587016720 putative DNA binding site [nucleotide binding]; other site 706587016721 metal binding site [ion binding]; metal-binding site 706587016722 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 706587016723 Phage terminase small subunit; Region: Phage_terminase; pfam10668 706587016724 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 706587016725 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 706587016726 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 706587016727 4Fe-4S binding domain; Region: Fer4; cl02805 706587016728 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 706587016729 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 706587016730 dimer interface [polypeptide binding]; other site 706587016731 PYR/PP interface [polypeptide binding]; other site 706587016732 TPP binding site [chemical binding]; other site 706587016733 substrate binding site [chemical binding]; other site 706587016734 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706587016735 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 706587016736 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 706587016737 TPP-binding site [chemical binding]; other site 706587016738 putative dimer interface [polypeptide binding]; other site 706587016739 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 706587016740 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 706587016741 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 706587016742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587016743 dimer interface [polypeptide binding]; other site 706587016744 conserved gate region; other site 706587016745 putative PBP binding loops; other site 706587016746 ABC-ATPase subunit interface; other site 706587016747 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 706587016748 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 706587016749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706587016750 dimer interface [polypeptide binding]; other site 706587016751 conserved gate region; other site 706587016752 putative PBP binding loops; other site 706587016753 ABC-ATPase subunit interface; other site 706587016754 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 706587016755 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706587016756 Walker A/P-loop; other site 706587016757 ATP binding site [chemical binding]; other site 706587016758 Q-loop/lid; other site 706587016759 ABC transporter signature motif; other site 706587016760 Walker B; other site 706587016761 D-loop; other site 706587016762 H-loop/switch region; other site 706587016763 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 706587016764 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 706587016765 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706587016766 Walker A/P-loop; other site 706587016767 ATP binding site [chemical binding]; other site 706587016768 Q-loop/lid; other site 706587016769 ABC transporter signature motif; other site 706587016770 Walker B; other site 706587016771 D-loop; other site 706587016772 H-loop/switch region; other site 706587016773 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 706587016774 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 706587016775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706587016776 S-adenosylmethionine binding site [chemical binding]; other site 706587016777 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 706587016778 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 706587016779 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 706587016780 putative ligand binding pocket/active site [active] 706587016781 putative metal binding site [ion binding]; other site 706587016782 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 706587016783 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587016784 FtsX-like permease family; Region: FtsX; pfam02687 706587016785 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 706587016786 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706587016787 FtsX-like permease family; Region: FtsX; pfam02687 706587016788 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 706587016789 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 706587016790 Walker A/P-loop; other site 706587016791 ATP binding site [chemical binding]; other site 706587016792 Q-loop/lid; other site 706587016793 ABC transporter signature motif; other site 706587016794 Walker B; other site 706587016795 D-loop; other site 706587016796 H-loop/switch region; other site 706587016797 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706587016798 Flagellin N-methylase; Region: FliB; cl00497 706587016799 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 706587016800 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 706587016801 P-loop; other site 706587016802 Magnesium ion binding site [ion binding]; other site 706587016803 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 706587016804 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 706587016805 Magnesium ion binding site [ion binding]; other site 706587016806 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 706587016807 ParB-like nuclease domain; Region: ParBc; pfam02195 706587016808 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 706587016809 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 706587016810 RNA/DNA hybrid binding site [nucleotide binding]; other site 706587016811 active site 706587016812 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 706587016813 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 706587016814 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 706587016815 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 706587016816 P-loop; other site 706587016817 Magnesium ion binding site [ion binding]; other site 706587016818 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 706587016819 Magnesium ion binding site [ion binding]; other site 706587016820 Helix-turn-helix domain; Region: HTH_36; pfam13730 706587016821 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 706587016822 AAA ATPase domain; Region: AAA_16; pfam13191 706587016823 DEAD-like helicases superfamily; Region: DEXDc; smart00487 706587016824 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706587016825 ATP binding site [chemical binding]; other site 706587016826 putative Mg++ binding site [ion binding]; other site 706587016827 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706587016828 nucleotide binding region [chemical binding]; other site 706587016829 ATP-binding site [chemical binding]; other site 706587016830 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 706587016831 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 706587016832 putative cation:proton antiport protein; Provisional; Region: PRK10669 706587016833 TrkA-N domain; Region: TrkA_N; pfam02254 706587016834 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 706587016835 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 706587016836 Protein export membrane protein; Region: SecD_SecF; pfam02355 706587016837 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 706587016838 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 706587016839 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 706587016840 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 706587016841 active site 706587016842 DNA binding site [nucleotide binding] 706587016843 Int/Topo IB signature motif; other site 706587016844 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 706587016845 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 706587016846 active site 706587016847 substrate binding site [chemical binding]; other site 706587016848 catalytic site [active] 706587016849 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 706587016850 active site 706587016851 DNA binding site [nucleotide binding] 706587016852 catalytic site [active]