-- dump date 20140619_063302 -- class Genbank::misc_feature -- table misc_feature_note -- id note 646529000001 AAA domain; Region: AAA_31; pfam13614 646529000002 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 646529000003 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 646529000004 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 646529000005 Walker A motif; other site 646529000006 ATP binding site [chemical binding]; other site 646529000007 Walker B motif; other site 646529000008 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 646529000009 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 646529000010 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 646529000011 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 646529000012 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 646529000013 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 646529000014 dimer interface [polypeptide binding]; other site 646529000015 ssDNA binding site [nucleotide binding]; other site 646529000016 tetramer (dimer of dimers) interface [polypeptide binding]; other site 646529000017 SurA N-terminal domain; Region: SurA_N; pfam09312 646529000018 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 646529000019 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529000020 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529000021 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529000022 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 646529000023 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 646529000024 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 646529000025 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 646529000026 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 646529000027 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 646529000028 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 646529000029 BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative...; Region: BPI; cl00188 646529000030 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 646529000031 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 646529000032 nucleotide binding site [chemical binding]; other site 646529000033 PLD-like domain; Region: PLDc_2; pfam13091 646529000034 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 646529000035 putative active site [active] 646529000036 catalytic site [active] 646529000037 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 646529000038 PLD-like domain; Region: PLDc_2; pfam13091 646529000039 putative active site [active] 646529000040 catalytic site [active] 646529000041 Helix-turn-helix domain; Region: HTH_17; pfam12728 646529000042 PemK-like protein; Region: PemK; pfam02452 646529000043 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 646529000044 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 646529000045 active site 646529000046 DNA binding site [nucleotide binding] 646529000047 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 646529000048 cyclase homology domain; Region: CHD; cd07302 646529000049 nucleotidyl binding site; other site 646529000050 metal binding site [ion binding]; metal-binding site 646529000051 dimer interface [polypeptide binding]; other site 646529000052 cyclase homology domain; Region: CHD; cd07302 646529000053 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 646529000054 nucleotidyl binding site; other site 646529000055 metal binding site [ion binding]; metal-binding site 646529000056 dimer interface [polypeptide binding]; other site 646529000057 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 646529000058 active site 646529000059 catalytic residues [active] 646529000060 DNA binding site [nucleotide binding] 646529000061 Int/Topo IB signature motif; other site 646529000062 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 646529000063 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 646529000064 P-loop; other site 646529000065 Magnesium ion binding site [ion binding]; other site 646529000066 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 646529000067 Helix-turn-helix domain; Region: HTH_17; pfam12728 646529000068 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 646529000069 2-isopropylmalate synthase; Validated; Region: PRK00915 646529000070 antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819 646529000071 toxin interface [polypeptide binding]; other site 646529000072 Zn binding site [ion binding]; other site 646529000073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529000074 non-specific DNA binding site [nucleotide binding]; other site 646529000075 salt bridge; other site 646529000076 sequence-specific DNA binding site [nucleotide binding]; other site 646529000077 GEMM cis-regulatory element 646529000078 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 646529000079 AAA-like domain; Region: AAA_10; pfam12846 646529000080 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 646529000081 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 646529000082 N-acetyl-D-glucosamine binding site [chemical binding]; other site 646529000083 catalytic residue [active] 646529000084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529000085 AAA-like domain; Region: AAA_10; pfam12846 646529000086 Walker A motif; other site 646529000087 ATP binding site [chemical binding]; other site 646529000088 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 646529000089 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 646529000090 Replication-relaxation; Region: Replic_Relax; pfam13814 646529000091 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 646529000092 AAA domain; Region: AAA_31; pfam13614 646529000093 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 646529000094 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 646529000095 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 646529000096 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 646529000097 FIC domain binding interface [polypeptide binding]; other site 646529000098 MarR family; Region: MarR_2; pfam12802 646529000099 MobA/MobL family; Region: MobA_MobL; pfam03389 646529000100 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 646529000101 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 646529000102 DnaA N-terminal domain; Region: DnaA_N; pfam11638 646529000103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529000104 Walker A motif; other site 646529000105 ATP binding site [chemical binding]; other site 646529000106 Walker B motif; other site 646529000107 arginine finger; other site 646529000108 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 646529000109 DnaA box-binding interface [nucleotide binding]; other site 646529000110 DNA polymerase III subunit beta; Validated; Region: PRK05643 646529000111 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 646529000112 putative DNA binding surface [nucleotide binding]; other site 646529000113 dimer interface [polypeptide binding]; other site 646529000114 beta-clamp/clamp loader binding surface; other site 646529000115 beta-clamp/translesion DNA polymerase binding surface; other site 646529000116 recombination protein F; Reviewed; Region: recF; PRK00064 646529000117 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 646529000118 Walker A/P-loop; other site 646529000119 ATP binding site [chemical binding]; other site 646529000120 Q-loop/lid; other site 646529000121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529000122 ABC transporter signature motif; other site 646529000123 Walker B; other site 646529000124 D-loop; other site 646529000125 H-loop/switch region; other site 646529000126 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 646529000127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529000128 Mg2+ binding site [ion binding]; other site 646529000129 G-X-G motif; other site 646529000130 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 646529000131 anchoring element; other site 646529000132 dimer interface [polypeptide binding]; other site 646529000133 ATP binding site [chemical binding]; other site 646529000134 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 646529000135 active site 646529000136 putative metal-binding site [ion binding]; other site 646529000137 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 646529000138 DNA gyrase subunit A; Validated; Region: PRK05560 646529000139 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 646529000140 CAP-like domain; other site 646529000141 active site 646529000142 primary dimer interface [polypeptide binding]; other site 646529000143 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 646529000144 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 646529000145 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 646529000146 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 646529000147 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 646529000148 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 646529000149 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 646529000150 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 646529000151 active site 646529000152 multimer interface [polypeptide binding]; other site 646529000153 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 646529000154 predicted active site [active] 646529000155 catalytic triad [active] 646529000156 seryl-tRNA synthetase; Provisional; Region: PRK05431 646529000157 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 646529000158 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 646529000159 dimer interface [polypeptide binding]; other site 646529000160 active site 646529000161 motif 1; other site 646529000162 motif 2; other site 646529000163 motif 3; other site 646529000164 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 646529000165 nucleoside/Zn binding site; other site 646529000166 dimer interface [polypeptide binding]; other site 646529000167 catalytic motif [active] 646529000168 DinB superfamily; Region: DinB_2; pfam12867 646529000169 DinB family; Region: DinB; cl17821 646529000170 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 646529000171 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 646529000172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529000173 Walker B motif; other site 646529000174 arginine finger; other site 646529000175 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 646529000176 hypothetical protein; Validated; Region: PRK00153 646529000177 recombination protein RecR; Reviewed; Region: recR; PRK00076 646529000178 RecR protein; Region: RecR; pfam02132 646529000179 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 646529000180 putative active site [active] 646529000181 putative metal-binding site [ion binding]; other site 646529000182 tetramer interface [polypeptide binding]; other site 646529000183 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 646529000184 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 646529000185 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 646529000186 dimer interface [polypeptide binding]; other site 646529000187 PYR/PP interface [polypeptide binding]; other site 646529000188 TPP binding site [chemical binding]; other site 646529000189 substrate binding site [chemical binding]; other site 646529000190 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 646529000191 Domain of unknown function; Region: EKR; smart00890 646529000192 4Fe-4S binding domain; Region: Fer4_6; pfam12837 646529000193 4Fe-4S binding domain; Region: Fer4; pfam00037 646529000194 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 646529000195 TPP-binding site [chemical binding]; other site 646529000196 dimer interface [polypeptide binding]; other site 646529000197 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 646529000198 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 646529000199 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 646529000200 Spore germination protein; Region: Spore_permease; cl17796 646529000201 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 646529000202 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 646529000203 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 646529000204 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 646529000205 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 646529000206 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 646529000207 catalytic residue [active] 646529000208 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 646529000209 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 646529000210 DNA polymerase III subunit delta'; Validated; Region: PRK08485 646529000211 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 646529000212 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 646529000213 Protein of unknown function (DUF972); Region: DUF972; pfam06156 646529000214 Predicted methyltransferases [General function prediction only]; Region: COG0313 646529000215 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 646529000216 putative SAM binding site [chemical binding]; other site 646529000217 putative homodimer interface [polypeptide binding]; other site 646529000218 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 646529000219 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 646529000220 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 646529000221 active site 646529000222 HIGH motif; other site 646529000223 KMSKS motif; other site 646529000224 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 646529000225 tRNA binding surface [nucleotide binding]; other site 646529000226 anticodon binding site; other site 646529000227 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 646529000228 dimer interface [polypeptide binding]; other site 646529000229 putative tRNA-binding site [nucleotide binding]; other site 646529000230 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 646529000231 active site 646529000232 G5 domain; Region: G5; pfam07501 646529000233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 646529000234 Domain of unknown function (DUF348); Region: DUF348; pfam03990 646529000235 Domain of unknown function (DUF348); Region: DUF348; pfam03990 646529000236 G5 domain; Region: G5; pfam07501 646529000237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 646529000238 Transposase domain (DUF772); Region: DUF772; pfam05598 646529000239 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 646529000240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529000241 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529000242 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529000243 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 646529000244 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 646529000245 active site 646529000246 metal binding site [ion binding]; metal-binding site 646529000247 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 646529000248 Glyco_18 domain; Region: Glyco_18; smart00636 646529000249 active site 646529000250 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 646529000251 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 646529000252 putative active site [active] 646529000253 putative metal binding site [ion binding]; other site 646529000254 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 646529000255 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 646529000256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529000257 S-adenosylmethionine binding site [chemical binding]; other site 646529000258 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 646529000259 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 646529000260 active site 646529000261 YabG peptidase U57; Region: Peptidase_U57; pfam05582 646529000262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 646529000263 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 646529000264 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 646529000265 proposed catalytic triad [active] 646529000266 active site nucleophile [active] 646529000267 cyanophycin synthetase; Provisional; Region: PRK14016 646529000268 ATP-grasp domain; Region: ATP-grasp_4; cl17255 646529000269 ATP-grasp domain; Region: ATP-grasp_4; cl17255 646529000270 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 646529000271 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 646529000272 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 646529000273 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 646529000274 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 646529000275 Transcriptional regulators [Transcription]; Region: GntR; COG1802 646529000276 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529000277 DNA-binding site [nucleotide binding]; DNA binding site 646529000278 FCD domain; Region: FCD; pfam07729 646529000279 pur operon repressor; Provisional; Region: PRK09213 646529000280 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 646529000281 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 646529000282 active site 646529000283 regulatory protein SpoVG; Reviewed; Region: PRK13259 646529000284 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 646529000285 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 646529000286 Substrate binding site; other site 646529000287 Mg++ binding site; other site 646529000288 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 646529000289 active site 646529000290 substrate binding site [chemical binding]; other site 646529000291 CoA binding site [chemical binding]; other site 646529000292 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 646529000293 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 646529000294 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 646529000295 active site 646529000296 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 646529000297 PRC-barrel domain; Region: PRC; pfam05239 646529000298 PRC-barrel domain; Region: PRC; pfam05239 646529000299 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 646529000300 putative active site [active] 646529000301 catalytic residue [active] 646529000302 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 646529000303 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 646529000304 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 646529000305 ATP binding site [chemical binding]; other site 646529000306 putative Mg++ binding site [ion binding]; other site 646529000307 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529000308 nucleotide binding region [chemical binding]; other site 646529000309 ATP-binding site [chemical binding]; other site 646529000310 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 646529000311 SurA N-terminal domain; Region: SurA_N; pfam09312 646529000312 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 646529000313 stage V sporulation protein T; Region: spore_V_T; TIGR02851 646529000314 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 646529000315 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 646529000316 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 646529000317 active site 646529000318 homodimer interface [polypeptide binding]; other site 646529000319 SAM binding site [chemical binding]; other site 646529000320 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 646529000321 homodimer interface [polypeptide binding]; other site 646529000322 metal binding site [ion binding]; metal-binding site 646529000323 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 646529000324 homodimer interface [polypeptide binding]; other site 646529000325 active site 646529000326 putative chemical substrate binding site [chemical binding]; other site 646529000327 metal binding site [ion binding]; metal-binding site 646529000328 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 646529000329 IHF dimer interface [polypeptide binding]; other site 646529000330 IHF - DNA interface [nucleotide binding]; other site 646529000331 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 646529000332 RNA binding surface [nucleotide binding]; other site 646529000333 YabP family; Region: YabP; cl06766 646529000334 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578 646529000335 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529000336 DNA binding residues [nucleotide binding] 646529000337 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 646529000338 Septum formation initiator; Region: DivIC; pfam04977 646529000339 hypothetical protein; Provisional; Region: PRK08582 646529000340 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 646529000341 RNA binding site [nucleotide binding]; other site 646529000342 stage II sporulation protein E; Region: spore_II_E; TIGR02865 646529000343 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 646529000344 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 646529000345 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 646529000346 Potassium binding sites [ion binding]; other site 646529000347 Cesium cation binding sites [ion binding]; other site 646529000348 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 646529000349 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 646529000350 Ligand Binding Site [chemical binding]; other site 646529000351 TilS substrate C-terminal domain; Region: TilS_C; smart00977 646529000352 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 646529000353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529000354 Walker A motif; other site 646529000355 ATP binding site [chemical binding]; other site 646529000356 Walker B motif; other site 646529000357 arginine finger; other site 646529000358 Peptidase family M41; Region: Peptidase_M41; pfam01434 646529000359 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 646529000360 active site 646529000361 multimer interface [polypeptide binding]; other site 646529000362 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 646529000363 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 646529000364 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529000365 Zn2+ binding site [ion binding]; other site 646529000366 Mg2+ binding site [ion binding]; other site 646529000367 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 646529000368 dihydropteroate synthase; Region: DHPS; TIGR01496 646529000369 substrate binding pocket [chemical binding]; other site 646529000370 dimer interface [polypeptide binding]; other site 646529000371 inhibitor binding site; inhibition site 646529000372 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 646529000373 homooctamer interface [polypeptide binding]; other site 646529000374 active site 646529000375 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 646529000376 catalytic center binding site [active] 646529000377 ATP binding site [chemical binding]; other site 646529000378 Rossmann-like domain; Region: Rossmann-like; pfam10727 646529000379 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 646529000380 pantoate--beta-alanine ligase; Region: panC; TIGR00018 646529000381 Pantoate-beta-alanine ligase; Region: PanC; cd00560 646529000382 active site 646529000383 ATP-binding site [chemical binding]; other site 646529000384 pantoate-binding site; other site 646529000385 HXXH motif; other site 646529000386 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 646529000387 tetramerization interface [polypeptide binding]; other site 646529000388 active site 646529000389 Biotin operon repressor [Transcription]; Region: BirA; COG1654 646529000390 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 646529000391 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 646529000392 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 646529000393 BioY family; Region: BioY; pfam02632 646529000394 pantothenate kinase; Reviewed; Region: PRK13318 646529000395 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 646529000396 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 646529000397 FMN binding site [chemical binding]; other site 646529000398 active site 646529000399 catalytic residues [active] 646529000400 substrate binding site [chemical binding]; other site 646529000401 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 646529000402 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 646529000403 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 646529000404 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 646529000405 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 646529000406 dimer interface [polypeptide binding]; other site 646529000407 putative anticodon binding site; other site 646529000408 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 646529000409 motif 1; other site 646529000410 active site 646529000411 motif 2; other site 646529000412 motif 3; other site 646529000413 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 646529000414 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 646529000415 ligand binding site [chemical binding]; other site 646529000416 flexible hinge region; other site 646529000417 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 646529000418 putative switch regulator; other site 646529000419 non-specific DNA interactions [nucleotide binding]; other site 646529000420 DNA binding site [nucleotide binding] 646529000421 sequence specific DNA binding site [nucleotide binding]; other site 646529000422 putative cAMP binding site [chemical binding]; other site 646529000423 Domain of unknown function (DUF373); Region: DUF373; cl12079 646529000424 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 646529000425 CoA binding domain; Region: CoA_binding_2; pfam13380 646529000426 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 646529000427 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 646529000428 DXD motif; other site 646529000429 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 646529000430 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529000431 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529000432 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529000433 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 646529000434 Malic enzyme, N-terminal domain; Region: malic; pfam00390 646529000435 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 646529000436 putative NAD(P) binding site [chemical binding]; other site 646529000437 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 646529000438 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 646529000439 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 646529000440 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 646529000441 L-aspartate oxidase; Provisional; Region: PRK06175 646529000442 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 646529000443 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 646529000444 putative Iron-sulfur protein interface [polypeptide binding]; other site 646529000445 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 646529000446 proximal heme binding site [chemical binding]; other site 646529000447 distal heme binding site [chemical binding]; other site 646529000448 putative dimer interface [polypeptide binding]; other site 646529000449 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 646529000450 PAS domain; Region: PAS; smart00091 646529000451 PAS fold; Region: PAS_4; pfam08448 646529000452 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 646529000453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529000454 Walker A motif; other site 646529000455 ATP binding site [chemical binding]; other site 646529000456 Walker B motif; other site 646529000457 arginine finger; other site 646529000458 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529000459 fumarate hydratase; Provisional; Region: PRK06246 646529000460 Fumarase C-terminus; Region: Fumerase_C; cl00795 646529000461 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 646529000462 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 646529000463 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529000464 putative active site [active] 646529000465 heme pocket [chemical binding]; other site 646529000466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529000467 dimer interface [polypeptide binding]; other site 646529000468 phosphorylation site [posttranslational modification] 646529000469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529000470 ATP binding site [chemical binding]; other site 646529000471 Mg2+ binding site [ion binding]; other site 646529000472 G-X-G motif; other site 646529000473 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 646529000474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529000475 active site 646529000476 phosphorylation site [posttranslational modification] 646529000477 intermolecular recognition site; other site 646529000478 dimerization interface [polypeptide binding]; other site 646529000479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529000480 Walker A motif; other site 646529000481 ATP binding site [chemical binding]; other site 646529000482 Walker B motif; other site 646529000483 arginine finger; other site 646529000484 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529000485 benzoate transport; Region: 2A0115; TIGR00895 646529000486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529000487 putative substrate translocation pore; other site 646529000488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529000489 D-galactonate transporter; Region: 2A0114; TIGR00893 646529000490 putative substrate translocation pore; other site 646529000491 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 646529000492 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 646529000493 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 646529000494 catalytic residue [active] 646529000495 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 646529000496 spermidine synthase; Provisional; Region: PRK00811 646529000497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529000498 S-adenosylmethionine binding site [chemical binding]; other site 646529000499 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 646529000500 MgtC family; Region: MgtC; pfam02308 646529000501 YtxC-like family; Region: YtxC; pfam08812 646529000502 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 646529000503 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 646529000504 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 646529000505 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 646529000506 active site 646529000507 dimer interface [polypeptide binding]; other site 646529000508 motif 1; other site 646529000509 motif 2; other site 646529000510 motif 3; other site 646529000511 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 646529000512 anticodon binding site; other site 646529000513 Ribosomal protein L20 leader 646529000514 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 646529000515 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 646529000516 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 646529000517 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 646529000518 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 646529000519 23S rRNA binding site [nucleotide binding]; other site 646529000520 L21 binding site [polypeptide binding]; other site 646529000521 L13 binding site [polypeptide binding]; other site 646529000522 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 646529000523 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 646529000524 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 646529000525 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 646529000526 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 646529000527 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 646529000528 dimer interface [polypeptide binding]; other site 646529000529 motif 1; other site 646529000530 active site 646529000531 motif 2; other site 646529000532 motif 3; other site 646529000533 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 646529000534 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 646529000535 putative tRNA-binding site [nucleotide binding]; other site 646529000536 B3/4 domain; Region: B3_4; pfam03483 646529000537 tRNA synthetase B5 domain; Region: B5; smart00874 646529000538 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 646529000539 dimer interface [polypeptide binding]; other site 646529000540 motif 1; other site 646529000541 motif 3; other site 646529000542 motif 2; other site 646529000543 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 646529000544 Cell division protein ZapA; Region: ZapA; cl01146 646529000545 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 646529000546 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 646529000547 Peptidase family U32; Region: Peptidase_U32; pfam01136 646529000548 Collagenase; Region: DUF3656; pfam12392 646529000549 Peptidase family U32; Region: Peptidase_U32; pfam01136 646529000550 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 646529000551 MutS domain III; Region: MutS_III; pfam05192 646529000552 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 646529000553 Walker A/P-loop; other site 646529000554 ATP binding site [chemical binding]; other site 646529000555 Q-loop/lid; other site 646529000556 ABC transporter signature motif; other site 646529000557 Walker B; other site 646529000558 D-loop; other site 646529000559 H-loop/switch region; other site 646529000560 Smr domain; Region: Smr; pfam01713 646529000561 Transglycosylase; Region: Transgly; pfam00912 646529000562 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 646529000563 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 646529000564 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 646529000565 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 646529000566 active site 646529000567 HIGH motif; other site 646529000568 dimer interface [polypeptide binding]; other site 646529000569 KMSKS motif; other site 646529000570 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 646529000571 RNA binding surface [nucleotide binding]; other site 646529000572 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529000573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529000574 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529000575 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 646529000576 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 646529000577 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 646529000578 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 646529000579 Spore germination protein; Region: Spore_permease; cl17796 646529000580 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 646529000581 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 646529000582 ATP cone domain; Region: ATP-cone; pfam03477 646529000583 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 646529000584 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 646529000585 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 646529000586 active site 646529000587 dimer interface [polypeptide binding]; other site 646529000588 effector binding site; other site 646529000589 TSCPD domain; Region: TSCPD; pfam12637 646529000590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529000591 Coenzyme A binding pocket [chemical binding]; other site 646529000592 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 646529000593 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 646529000594 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 646529000595 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 646529000596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529000597 S-adenosylmethionine binding site [chemical binding]; other site 646529000598 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 646529000599 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529000600 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529000601 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529000602 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 646529000603 Predicted transcriptional regulator [Transcription]; Region: COG1959 646529000604 Transcriptional regulator; Region: Rrf2; pfam02082 646529000605 Transposase [DNA replication, recombination, and repair]; Region: COG5421 646529000606 Immunity protein Imm1; Region: Imm1; pfam14430 646529000607 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 646529000608 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 646529000609 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 646529000610 nudix motif; other site 646529000611 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 646529000612 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 646529000613 Metal-binding active site; metal-binding site 646529000614 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 646529000615 Protein of unknown function; Region: DUF3658; pfam12395 646529000616 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 646529000617 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_3; cd09321 646529000618 gating phenylalanine in ion channel; other site 646529000619 DNA polymerase IV; Reviewed; Region: PRK03103 646529000620 Y-family of DNA polymerases; Region: PolY; cl12025 646529000621 active site 646529000622 DNA binding site [nucleotide binding] 646529000623 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 646529000624 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 646529000625 Mg++ binding site [ion binding]; other site 646529000626 putative catalytic motif [active] 646529000627 substrate binding site [chemical binding]; other site 646529000628 sensory histidine kinase AtoS; Provisional; Region: PRK11360 646529000629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529000630 putative active site [active] 646529000631 heme pocket [chemical binding]; other site 646529000632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529000633 dimer interface [polypeptide binding]; other site 646529000634 phosphorylation site [posttranslational modification] 646529000635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529000636 ATP binding site [chemical binding]; other site 646529000637 Mg2+ binding site [ion binding]; other site 646529000638 G-X-G motif; other site 646529000639 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 646529000640 Uncharacterized conserved protein [Function unknown]; Region: COG1683 646529000641 Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133 646529000642 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 646529000643 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 646529000644 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 646529000645 Walker A/P-loop; other site 646529000646 ATP binding site [chemical binding]; other site 646529000647 Q-loop/lid; other site 646529000648 ABC transporter signature motif; other site 646529000649 Walker B; other site 646529000650 D-loop; other site 646529000651 H-loop/switch region; other site 646529000652 cobalt transport protein CbiM; Provisional; Region: PRK07331 646529000653 cobalt transport protein CbiM; Provisional; Region: PRK11909 646529000654 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529000655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529000656 putative substrate translocation pore; other site 646529000657 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 646529000658 Methyltransferase domain; Region: Methyltransf_23; pfam13489 646529000659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529000660 S-adenosylmethionine binding site [chemical binding]; other site 646529000661 Transcriptional regulators [Transcription]; Region: FadR; COG2186 646529000662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529000663 DNA-binding site [nucleotide binding]; DNA binding site 646529000664 FCD domain; Region: FCD; pfam07729 646529000665 Chromate transporter; Region: Chromate_transp; pfam02417 646529000666 Chromate transporter; Region: Chromate_transp; pfam02417 646529000667 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 646529000668 ligand binding site [chemical binding]; other site 646529000669 active site 646529000670 UGI interface [polypeptide binding]; other site 646529000671 catalytic site [active] 646529000672 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 646529000673 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 646529000674 active site 646529000675 metal binding site [ion binding]; metal-binding site 646529000676 DNA binding site [nucleotide binding] 646529000677 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 646529000678 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 646529000679 AAA domain; Region: AAA_23; pfam13476 646529000680 Walker A/P-loop; other site 646529000681 ATP binding site [chemical binding]; other site 646529000682 Q-loop/lid; other site 646529000683 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 646529000684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529000685 ABC transporter signature motif; other site 646529000686 Walker B; other site 646529000687 D-loop; other site 646529000688 H-loop/switch region; other site 646529000689 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 646529000690 Transcriptional regulator [Transcription]; Region: IclR; COG1414 646529000691 Bacterial transcriptional regulator; Region: IclR; pfam01614 646529000692 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 646529000693 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529000694 Cysteine-rich domain; Region: CCG; pfam02754 646529000695 Cysteine-rich domain; Region: CCG; pfam02754 646529000696 FAD binding domain; Region: FAD_binding_4; pfam01565 646529000697 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 646529000698 FAD binding domain; Region: FAD_binding_4; pfam01565 646529000699 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 646529000700 Cupin domain; Region: Cupin_2; cl17218 646529000701 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 646529000702 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 646529000703 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 646529000704 CoA binding domain; Region: CoA_binding; smart00881 646529000705 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 646529000706 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 646529000707 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 646529000708 Malic enzyme, N-terminal domain; Region: malic; pfam00390 646529000709 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 646529000710 putative NAD(P) binding site [chemical binding]; other site 646529000711 DinB family; Region: DinB; cl17821 646529000712 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 646529000713 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529000714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529000715 putative substrate translocation pore; other site 646529000716 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 646529000717 Ligand Binding Site [chemical binding]; other site 646529000718 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 646529000719 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 646529000720 UvrB/uvrC motif; Region: UVR; pfam02151 646529000721 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 646529000722 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 646529000723 ADP binding site [chemical binding]; other site 646529000724 phosphagen binding site; other site 646529000725 substrate specificity loop; other site 646529000726 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 646529000727 Clp amino terminal domain; Region: Clp_N; pfam02861 646529000728 Clp amino terminal domain; Region: Clp_N; pfam02861 646529000729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529000730 Walker A motif; other site 646529000731 ATP binding site [chemical binding]; other site 646529000732 Walker B motif; other site 646529000733 arginine finger; other site 646529000734 UvrB/uvrC motif; Region: UVR; pfam02151 646529000735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529000736 Walker A motif; other site 646529000737 ATP binding site [chemical binding]; other site 646529000738 Walker B motif; other site 646529000739 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 646529000740 DNA repair protein RadA; Provisional; Region: PRK11823 646529000741 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 646529000742 Walker A motif; other site 646529000743 ATP binding site [chemical binding]; other site 646529000744 Walker B motif; other site 646529000745 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 646529000746 DsrE/DsrF-like family; Region: DrsE; pfam02635 646529000747 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 646529000748 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 646529000749 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 646529000750 Rubredoxin [Energy production and conversion]; Region: COG1773 646529000751 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 646529000752 iron binding site [ion binding]; other site 646529000753 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529000754 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 646529000755 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529000756 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 646529000757 dimer interface [polypeptide binding]; other site 646529000758 active site 646529000759 citrylCoA binding site [chemical binding]; other site 646529000760 Citrate synthase; Region: Citrate_synt; pfam00285 646529000761 oxalacetate/citrate binding site [chemical binding]; other site 646529000762 coenzyme A binding site [chemical binding]; other site 646529000763 catalytic triad [active] 646529000764 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 646529000765 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 646529000766 DNA binding residues [nucleotide binding] 646529000767 dimer interface [polypeptide binding]; other site 646529000768 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 646529000769 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 646529000770 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 646529000771 NodB motif; other site 646529000772 active site 646529000773 catalytic site [active] 646529000774 metal binding site [ion binding]; metal-binding site 646529000775 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 646529000776 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 646529000777 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 646529000778 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 646529000779 active site 646529000780 Domain of unknown function DUF77; Region: DUF77; pfam01910 646529000781 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 646529000782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529000783 dimer interface [polypeptide binding]; other site 646529000784 conserved gate region; other site 646529000785 putative PBP binding loops; other site 646529000786 ABC-ATPase subunit interface; other site 646529000787 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 646529000788 NMT1/THI5 like; Region: NMT1; pfam09084 646529000789 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 646529000790 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 646529000791 Walker A/P-loop; other site 646529000792 ATP binding site [chemical binding]; other site 646529000793 Q-loop/lid; other site 646529000794 ABC transporter signature motif; other site 646529000795 Walker B; other site 646529000796 D-loop; other site 646529000797 H-loop/switch region; other site 646529000798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529000799 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529000800 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 646529000801 nudix motif; other site 646529000802 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 646529000803 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 646529000804 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 646529000805 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 646529000806 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 646529000807 ACS interaction site; other site 646529000808 CODH interaction site; other site 646529000809 cubane metal cluster (B-cluster) [ion binding]; other site 646529000810 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 646529000811 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 646529000812 Methyltransferase domain; Region: Methyltransf_23; pfam13489 646529000813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529000814 S-adenosylmethionine binding site [chemical binding]; other site 646529000815 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 646529000816 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 646529000817 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 646529000818 FAD binding domain; Region: FAD_binding_4; pfam01565 646529000819 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 646529000820 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 646529000821 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 646529000822 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 646529000823 Ligand binding site [chemical binding]; other site 646529000824 Electron transfer flavoprotein domain; Region: ETF; pfam01012 646529000825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529000826 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 646529000827 Walker A/P-loop; other site 646529000828 ATP binding site [chemical binding]; other site 646529000829 Q-loop/lid; other site 646529000830 ABC transporter signature motif; other site 646529000831 Walker B; other site 646529000832 D-loop; other site 646529000833 H-loop/switch region; other site 646529000834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529000835 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529000836 dimerization interface [polypeptide binding]; other site 646529000837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529000838 dimer interface [polypeptide binding]; other site 646529000839 phosphorylation site [posttranslational modification] 646529000840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529000841 ATP binding site [chemical binding]; other site 646529000842 Mg2+ binding site [ion binding]; other site 646529000843 G-X-G motif; other site 646529000844 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529000845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529000846 active site 646529000847 phosphorylation site [posttranslational modification] 646529000848 intermolecular recognition site; other site 646529000849 dimerization interface [polypeptide binding]; other site 646529000850 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529000851 DNA binding site [nucleotide binding] 646529000852 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 646529000853 dinuclear metal binding motif [ion binding]; other site 646529000854 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 646529000855 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529000856 DNA binding residues [nucleotide binding] 646529000857 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 646529000858 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 646529000859 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 646529000860 P loop nucleotide binding; other site 646529000861 switch II; other site 646529000862 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 646529000863 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 646529000864 P loop nucleotide binding; other site 646529000865 switch II; other site 646529000866 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529000867 Cysteine-rich domain; Region: CCG; pfam02754 646529000868 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 646529000869 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 646529000870 Glutamine amidotransferase class-I; Region: GATase; pfam00117 646529000871 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 646529000872 glutamine binding [chemical binding]; other site 646529000873 catalytic triad [active] 646529000874 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 646529000875 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 646529000876 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 646529000877 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 646529000878 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 646529000879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529000880 catalytic residue [active] 646529000881 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 646529000882 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 646529000883 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 646529000884 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 646529000885 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 646529000886 Amidinotransferase; Region: Amidinotransf; pfam02274 646529000887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529000888 dimerization interface [polypeptide binding]; other site 646529000889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529000890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529000891 dimer interface [polypeptide binding]; other site 646529000892 phosphorylation site [posttranslational modification] 646529000893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529000894 ATP binding site [chemical binding]; other site 646529000895 Mg2+ binding site [ion binding]; other site 646529000896 G-X-G motif; other site 646529000897 Response regulator receiver domain; Region: Response_reg; pfam00072 646529000898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529000899 active site 646529000900 phosphorylation site [posttranslational modification] 646529000901 intermolecular recognition site; other site 646529000902 dimerization interface [polypeptide binding]; other site 646529000903 Response regulator receiver domain; Region: Response_reg; pfam00072 646529000904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529000905 active site 646529000906 phosphorylation site [posttranslational modification] 646529000907 intermolecular recognition site; other site 646529000908 dimerization interface [polypeptide binding]; other site 646529000909 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 646529000910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529000911 active site 646529000912 phosphorylation site [posttranslational modification] 646529000913 intermolecular recognition site; other site 646529000914 dimerization interface [polypeptide binding]; other site 646529000915 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 646529000916 DNA binding residues [nucleotide binding] 646529000917 dimerization interface [polypeptide binding]; other site 646529000918 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 646529000919 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 646529000920 catalytic triad [active] 646529000921 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 646529000922 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 646529000923 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 646529000924 active site 646529000925 metal binding site [ion binding]; metal-binding site 646529000926 endonuclease IV; Provisional; Region: PRK01060 646529000927 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 646529000928 AP (apurinic/apyrimidinic) site pocket; other site 646529000929 DNA interaction; other site 646529000930 Metal-binding active site; metal-binding site 646529000931 plasmid segregation protein ParM; Provisional; Region: PRK13917 646529000932 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 646529000933 Mg binding site [ion binding]; other site 646529000934 nucleotide binding site [chemical binding]; other site 646529000935 putative protofilament interface [polypeptide binding]; other site 646529000936 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 646529000937 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 646529000938 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 646529000939 putative dimer interface [polypeptide binding]; other site 646529000940 [2Fe-2S] cluster binding site [ion binding]; other site 646529000941 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 646529000942 dimer interface [polypeptide binding]; other site 646529000943 [2Fe-2S] cluster binding site [ion binding]; other site 646529000944 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 646529000945 SLBB domain; Region: SLBB; pfam10531 646529000946 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 646529000947 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 646529000948 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529000949 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529000950 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 646529000951 catalytic loop [active] 646529000952 iron binding site [ion binding]; other site 646529000953 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 646529000954 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 646529000955 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 646529000956 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 646529000957 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 646529000958 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 646529000959 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529000960 FeS/SAM binding site; other site 646529000961 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 646529000962 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 646529000963 Aspartase; Region: Aspartase; cd01357 646529000964 active sites [active] 646529000965 tetramer interface [polypeptide binding]; other site 646529000966 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 646529000967 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 646529000968 G1 box; other site 646529000969 GTP/Mg2+ binding site [chemical binding]; other site 646529000970 Switch I region; other site 646529000971 G2 box; other site 646529000972 Switch II region; other site 646529000973 G3 box; other site 646529000974 G4 box; other site 646529000975 G5 box; other site 646529000976 biotin synthase; Provisional; Region: PRK07094 646529000977 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529000978 FeS/SAM binding site; other site 646529000979 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 646529000980 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 646529000981 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529000982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529000983 dimer interface [polypeptide binding]; other site 646529000984 phosphorylation site [posttranslational modification] 646529000985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529000986 ATP binding site [chemical binding]; other site 646529000987 Mg2+ binding site [ion binding]; other site 646529000988 G-X-G motif; other site 646529000989 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529000990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529000991 active site 646529000992 phosphorylation site [posttranslational modification] 646529000993 intermolecular recognition site; other site 646529000994 dimerization interface [polypeptide binding]; other site 646529000995 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529000996 DNA binding site [nucleotide binding] 646529000997 nascent polypeptide-associated complex protein; Reviewed; Region: nac; PRK06369 646529000998 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 646529000999 active site 646529001000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529001001 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529001002 putative substrate translocation pore; other site 646529001003 Transcriptional regulator [Transcription]; Region: LysR; COG0583 646529001004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 646529001005 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 646529001006 putative dimerization interface [polypeptide binding]; other site 646529001007 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 646529001008 active site 646529001009 NTP binding site [chemical binding]; other site 646529001010 metal binding triad [ion binding]; metal-binding site 646529001011 antibiotic binding site [chemical binding]; other site 646529001012 Uncharacterized conserved protein [Function unknown]; Region: COG2445 646529001013 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 646529001014 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 646529001015 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 646529001016 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529001017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529001018 hydrogenase 4 subunit B; Validated; Region: PRK06521 646529001019 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 646529001020 NADH dehydrogenase; Region: NADHdh; cl00469 646529001021 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 646529001022 hydrogenase 4 subunit F; Validated; Region: PRK06458 646529001023 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 646529001024 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 646529001025 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 646529001026 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 646529001027 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 646529001028 4Fe-4S binding domain; Region: Fer4; pfam00037 646529001029 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 646529001030 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 646529001031 EamA-like transporter family; Region: EamA; pfam00892 646529001032 EamA-like transporter family; Region: EamA; pfam00892 646529001033 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 646529001034 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 646529001035 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 646529001036 nucleotide binding site/active site [active] 646529001037 HIT family signature motif; other site 646529001038 catalytic residue [active] 646529001039 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 646529001040 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 646529001041 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 646529001042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 646529001043 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 646529001044 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 646529001045 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 646529001046 MarR family; Region: MarR_2; pfam12802 646529001047 MarR family; Region: MarR_2; cl17246 646529001048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529001049 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529001050 putative substrate translocation pore; other site 646529001051 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 646529001052 dimerization interface [polypeptide binding]; other site 646529001053 putative DNA binding site [nucleotide binding]; other site 646529001054 putative Zn2+ binding site [ion binding]; other site 646529001055 Protein of unknown function, DUF270; Region: Otopetrin; pfam03189 646529001056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529001057 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 646529001058 putative active site [active] 646529001059 heme pocket [chemical binding]; other site 646529001060 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529001061 putative active site [active] 646529001062 heme pocket [chemical binding]; other site 646529001063 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529001064 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529001065 metal binding site [ion binding]; metal-binding site 646529001066 active site 646529001067 I-site; other site 646529001068 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 646529001069 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 646529001070 active site residue [active] 646529001071 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 646529001072 MarR family; Region: MarR_2; pfam12802 646529001073 MarR family; Region: MarR_2; cl17246 646529001074 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 646529001075 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 646529001076 Uncharacterized conserved protein [Function unknown]; Region: COG2006 646529001077 Domain of unknown function (DUF362); Region: DUF362; pfam04015 646529001078 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529001079 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 646529001080 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 646529001081 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 646529001082 ATP binding site [chemical binding]; other site 646529001083 putative Mg++ binding site [ion binding]; other site 646529001084 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529001085 nucleotide binding region [chemical binding]; other site 646529001086 ATP-binding site [chemical binding]; other site 646529001087 Nuclease-related domain; Region: NERD; pfam08378 646529001088 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 646529001089 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 646529001090 catalytic core [active] 646529001091 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 646529001092 PLD-like domain; Region: PLDc_2; pfam13091 646529001093 putative homodimer interface [polypeptide binding]; other site 646529001094 putative active site [active] 646529001095 catalytic site [active] 646529001096 DEAD-like helicases superfamily; Region: DEXDc; smart00487 646529001097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 646529001098 ATP binding site [chemical binding]; other site 646529001099 putative Mg++ binding site [ion binding]; other site 646529001100 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529001101 nucleotide binding region [chemical binding]; other site 646529001102 ATP-binding site [chemical binding]; other site 646529001103 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 646529001104 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 646529001105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529001106 non-specific DNA binding site [nucleotide binding]; other site 646529001107 salt bridge; other site 646529001108 sequence-specific DNA binding site [nucleotide binding]; other site 646529001109 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 646529001110 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 646529001111 active site 646529001112 catalytic site [active] 646529001113 substrate binding site [chemical binding]; other site 646529001114 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 646529001115 Transposase domain (DUF772); Region: DUF772; pfam05598 646529001116 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 646529001117 hypothetical protein; Provisional; Region: PRK09897 646529001118 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529001119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529001120 4Fe-4S binding domain; Region: Fer4; pfam00037 646529001121 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 646529001122 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 646529001123 putative FMN binding site [chemical binding]; other site 646529001124 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 646529001125 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 646529001126 MarR family; Region: MarR; pfam01047 646529001127 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 646529001128 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 646529001129 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 646529001130 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 646529001131 active site residue [active] 646529001132 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 646529001133 CPxP motif; other site 646529001134 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 646529001135 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 646529001136 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529001137 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529001138 DNA binding residues [nucleotide binding] 646529001139 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 646529001140 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 646529001141 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 646529001142 catalytic residues [active] 646529001143 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 646529001144 CoenzymeA binding site [chemical binding]; other site 646529001145 subunit interaction site [polypeptide binding]; other site 646529001146 PHB binding site; other site 646529001147 Predicted ATPase [General function prediction only]; Region: COG3910 646529001148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529001149 Walker A/P-loop; other site 646529001150 ATP binding site [chemical binding]; other site 646529001151 Q-loop/lid; other site 646529001152 ABC transporter signature motif; other site 646529001153 Walker B; other site 646529001154 D-loop; other site 646529001155 H-loop/switch region; other site 646529001156 MutS domain III; Region: MutS_III; pfam05192 646529001157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529001158 Walker A/P-loop; other site 646529001159 ATP binding site [chemical binding]; other site 646529001160 Q-loop/lid; other site 646529001161 ABC transporter signature motif; other site 646529001162 Walker B; other site 646529001163 D-loop; other site 646529001164 H-loop/switch region; other site 646529001165 Protein of unknown function DUF89; Region: DUF89; cl15397 646529001166 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 646529001167 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 646529001168 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 646529001169 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 646529001170 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 646529001171 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 646529001172 Walker A/P-loop; other site 646529001173 ATP binding site [chemical binding]; other site 646529001174 Q-loop/lid; other site 646529001175 ABC transporter signature motif; other site 646529001176 Walker B; other site 646529001177 D-loop; other site 646529001178 H-loop/switch region; other site 646529001179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529001180 S-adenosylmethionine binding site [chemical binding]; other site 646529001181 Tetratricopeptide repeat; Region: TPR_12; pfam13424 646529001182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529001183 binding surface 646529001184 TPR motif; other site 646529001185 Tetratricopeptide repeat; Region: TPR_12; pfam13424 646529001186 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529001187 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529001188 metal binding site [ion binding]; metal-binding site 646529001189 active site 646529001190 I-site; other site 646529001191 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 646529001192 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 646529001193 Walker A/P-loop; other site 646529001194 ATP binding site [chemical binding]; other site 646529001195 Q-loop/lid; other site 646529001196 ABC transporter signature motif; other site 646529001197 Walker B; other site 646529001198 D-loop; other site 646529001199 H-loop/switch region; other site 646529001200 Predicted transcriptional regulators [Transcription]; Region: COG1725 646529001201 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529001202 DNA-binding site [nucleotide binding]; DNA binding site 646529001203 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 646529001204 intracellular protease, PfpI family; Region: PfpI; TIGR01382 646529001205 conserved cys residue [active] 646529001206 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 646529001207 dimer interface [polypeptide binding]; other site 646529001208 pyridoxal binding site [chemical binding]; other site 646529001209 ATP binding site [chemical binding]; other site 646529001210 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 646529001211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529001212 active site 646529001213 phosphorylation site [posttranslational modification] 646529001214 intermolecular recognition site; other site 646529001215 dimerization interface [polypeptide binding]; other site 646529001216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529001217 Walker A motif; other site 646529001218 ATP binding site [chemical binding]; other site 646529001219 Walker B motif; other site 646529001220 arginine finger; other site 646529001221 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529001222 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529001223 dimerization interface [polypeptide binding]; other site 646529001224 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 646529001225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529001226 dimer interface [polypeptide binding]; other site 646529001227 phosphorylation site [posttranslational modification] 646529001228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529001229 ATP binding site [chemical binding]; other site 646529001230 Mg2+ binding site [ion binding]; other site 646529001231 G-X-G motif; other site 646529001232 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 646529001233 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 646529001234 Isochorismatase family; Region: Isochorismatase; pfam00857 646529001235 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 646529001236 catalytic triad [active] 646529001237 dimer interface [polypeptide binding]; other site 646529001238 conserved cis-peptide bond; other site 646529001239 Uncharacterized conserved protein [Function unknown]; Region: COG2135 646529001240 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 646529001241 Rubredoxin; Region: Rubredoxin; pfam00301 646529001242 iron binding site [ion binding]; other site 646529001243 Rubrerythrin [Energy production and conversion]; Region: COG1592 646529001244 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 646529001245 diiron binding motif [ion binding]; other site 646529001246 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 646529001247 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 646529001248 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 646529001249 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 646529001250 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 646529001251 active site 646529001252 FMN binding site [chemical binding]; other site 646529001253 substrate binding site [chemical binding]; other site 646529001254 putative catalytic residue [active] 646529001255 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 646529001256 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 646529001257 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 646529001258 FAD binding pocket [chemical binding]; other site 646529001259 FAD binding motif [chemical binding]; other site 646529001260 phosphate binding motif [ion binding]; other site 646529001261 beta-alpha-beta structure motif; other site 646529001262 NAD binding pocket [chemical binding]; other site 646529001263 Iron coordination center [ion binding]; other site 646529001264 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 646529001265 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 646529001266 4Fe-4S binding domain; Region: Fer4; pfam00037 646529001267 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 646529001268 putative FMN binding site [chemical binding]; other site 646529001269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529001270 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 646529001271 Coenzyme A binding pocket [chemical binding]; other site 646529001272 Predicted dehydrogenase [General function prediction only]; Region: COG0579 646529001273 hydroxyglutarate oxidase; Provisional; Region: PRK11728 646529001274 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 646529001275 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 646529001276 acyl-activating enzyme (AAE) consensus motif; other site 646529001277 AMP binding site [chemical binding]; other site 646529001278 active site 646529001279 CoA binding site [chemical binding]; other site 646529001280 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 646529001281 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 646529001282 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 646529001283 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 646529001284 dimer interface [polypeptide binding]; other site 646529001285 PYR/PP interface [polypeptide binding]; other site 646529001286 TPP binding site [chemical binding]; other site 646529001287 substrate binding site [chemical binding]; other site 646529001288 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 646529001289 TPP-binding site; other site 646529001290 Domain of unknown function (DUF348); Region: DUF348; pfam03990 646529001291 Domain of unknown function (DUF348); Region: DUF348; pfam03990 646529001292 G5 domain; Region: G5; pfam07501 646529001293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 646529001294 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 646529001295 active site 646529001296 catalytic triad [active] 646529001297 oxyanion hole [active] 646529001298 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 646529001299 active site 646529001300 catalytic triad [active] 646529001301 oxyanion hole [active] 646529001302 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 646529001303 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 646529001304 DHHW protein; Region: DHHW; pfam14286 646529001305 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 646529001306 active site 646529001307 catalytic triad [active] 646529001308 oxyanion hole [active] 646529001309 Propionate catabolism activator; Region: PrpR_N; pfam06506 646529001310 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529001311 PAS domain; Region: PAS; smart00091 646529001312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529001313 Walker A motif; other site 646529001314 ATP binding site [chemical binding]; other site 646529001315 Walker B motif; other site 646529001316 arginine finger; other site 646529001317 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529001318 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 646529001319 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 646529001320 Rubredoxin [Energy production and conversion]; Region: COG1773 646529001321 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 646529001322 iron binding site [ion binding]; other site 646529001323 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 646529001324 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 646529001325 non-heme iron binding site [ion binding]; other site 646529001326 dimer interface [polypeptide binding]; other site 646529001327 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 646529001328 non-heme iron binding site [ion binding]; other site 646529001329 FOG: CBS domain [General function prediction only]; Region: COG0517 646529001330 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 646529001331 PAS domain; Region: PAS; smart00091 646529001332 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529001333 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529001334 putative active site [active] 646529001335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529001336 Walker A motif; other site 646529001337 ATP binding site [chemical binding]; other site 646529001338 Walker B motif; other site 646529001339 arginine finger; other site 646529001340 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529001341 putative acyltransferase; Provisional; Region: PRK05790 646529001342 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 646529001343 dimer interface [polypeptide binding]; other site 646529001344 active site 646529001345 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 646529001346 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 646529001347 FAD binding site [chemical binding]; other site 646529001348 homotetramer interface [polypeptide binding]; other site 646529001349 substrate binding pocket [chemical binding]; other site 646529001350 catalytic base [active] 646529001351 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 646529001352 Coenzyme A transferase; Region: CoA_trans; cl17247 646529001353 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 646529001354 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 646529001355 ATP-grasp domain; Region: ATP-grasp_4; cl17255 646529001356 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 646529001357 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 646529001358 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 646529001359 carboxyltransferase (CT) interaction site; other site 646529001360 biotinylation site [posttranslational modification]; other site 646529001361 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 646529001362 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 646529001363 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 646529001364 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 646529001365 dimer interface [polypeptide binding]; other site 646529001366 PYR/PP interface [polypeptide binding]; other site 646529001367 TPP binding site [chemical binding]; other site 646529001368 substrate binding site [chemical binding]; other site 646529001369 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 646529001370 Domain of unknown function; Region: EKR; smart00890 646529001371 4Fe-4S binding domain; Region: Fer4_6; pfam12837 646529001372 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 646529001373 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 646529001374 TPP-binding site [chemical binding]; other site 646529001375 dimer interface [polypeptide binding]; other site 646529001376 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 646529001377 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 646529001378 active site 646529001379 HIGH motif; other site 646529001380 nucleotide binding site [chemical binding]; other site 646529001381 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 646529001382 active site 646529001383 KMSKS motif; other site 646529001384 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 646529001385 tRNA binding surface [nucleotide binding]; other site 646529001386 anticodon binding site; other site 646529001387 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 646529001388 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 646529001389 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 646529001390 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 646529001391 ligand binding site [chemical binding]; other site 646529001392 flexible hinge region; other site 646529001393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529001394 Walker A motif; other site 646529001395 ATP binding site [chemical binding]; other site 646529001396 Walker B motif; other site 646529001397 arginine finger; other site 646529001398 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 646529001399 4Fe-4S binding domain; Region: Fer4_5; pfam12801 646529001400 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 646529001401 Cache domain; Region: Cache_1; pfam02743 646529001402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529001403 dimerization interface [polypeptide binding]; other site 646529001404 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 646529001405 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529001406 dimer interface [polypeptide binding]; other site 646529001407 putative CheW interface [polypeptide binding]; other site 646529001408 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 646529001409 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 646529001410 active site 646529001411 Ferredoxin [Energy production and conversion]; Region: COG1146 646529001412 4Fe-4S binding domain; Region: Fer4; cl02805 646529001413 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 646529001414 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 646529001415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 646529001416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 646529001417 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 646529001418 putative dimerization interface [polypeptide binding]; other site 646529001419 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529001420 Zn2+ binding site [ion binding]; other site 646529001421 Mg2+ binding site [ion binding]; other site 646529001422 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 646529001423 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529001424 Zn2+ binding site [ion binding]; other site 646529001425 Mg2+ binding site [ion binding]; other site 646529001426 acetyl-CoA synthetase; Provisional; Region: PRK00174 646529001427 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 646529001428 active site 646529001429 CoA binding site [chemical binding]; other site 646529001430 acyl-activating enzyme (AAE) consensus motif; other site 646529001431 AMP binding site [chemical binding]; other site 646529001432 acetate binding site [chemical binding]; other site 646529001433 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 646529001434 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 646529001435 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 646529001436 catalytic residue [active] 646529001437 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 646529001438 active site 646529001439 8-oxo-dGMP binding site [chemical binding]; other site 646529001440 nudix motif; other site 646529001441 metal binding site [ion binding]; metal-binding site 646529001442 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 646529001443 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 646529001444 stage V sporulation protein AD; Provisional; Region: PRK12404 646529001445 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 646529001446 SpoVA protein; Region: SpoVA; cl04298 646529001447 Predicted membrane protein [Function unknown]; Region: COG2323 646529001448 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 646529001449 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 646529001450 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529001451 dimer interface [polypeptide binding]; other site 646529001452 putative CheW interface [polypeptide binding]; other site 646529001453 sporulation sigma factor SigK; Reviewed; Region: PRK05803 646529001454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529001455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529001456 DNA binding residues [nucleotide binding] 646529001457 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 646529001458 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 646529001459 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 646529001460 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 646529001461 putative active site [active] 646529001462 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 646529001463 substrate binding site; other site 646529001464 dimer interface; other site 646529001465 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 646529001466 homotrimer interaction site [polypeptide binding]; other site 646529001467 zinc binding site [ion binding]; other site 646529001468 CDP-binding sites; other site 646529001469 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 646529001470 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 646529001471 HIGH motif; other site 646529001472 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 646529001473 active site 646529001474 KMSKS motif; other site 646529001475 serine O-acetyltransferase; Region: cysE; TIGR01172 646529001476 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 646529001477 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 646529001478 trimer interface [polypeptide binding]; other site 646529001479 active site 646529001480 substrate binding site [chemical binding]; other site 646529001481 CoA binding site [chemical binding]; other site 646529001482 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 646529001483 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 646529001484 active site 646529001485 HIGH motif; other site 646529001486 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 646529001487 KMSKS motif; other site 646529001488 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 646529001489 tRNA binding surface [nucleotide binding]; other site 646529001490 anticodon binding site; other site 646529001491 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 646529001492 active site 646529001493 metal binding site [ion binding]; metal-binding site 646529001494 dimerization interface [polypeptide binding]; other site 646529001495 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 646529001496 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 646529001497 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 646529001498 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 646529001499 RNA polymerase factor sigma-70; Validated; Region: PRK08295 646529001500 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529001501 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 646529001502 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 646529001503 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 646529001504 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 646529001505 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 646529001506 putative homodimer interface [polypeptide binding]; other site 646529001507 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 646529001508 heterodimer interface [polypeptide binding]; other site 646529001509 homodimer interface [polypeptide binding]; other site 646529001510 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 646529001511 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 646529001512 23S rRNA interface [nucleotide binding]; other site 646529001513 L7/L12 interface [polypeptide binding]; other site 646529001514 putative thiostrepton binding site; other site 646529001515 L25 interface [polypeptide binding]; other site 646529001516 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 646529001517 mRNA/rRNA interface [nucleotide binding]; other site 646529001518 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 646529001519 23S rRNA interface [nucleotide binding]; other site 646529001520 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 646529001521 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 646529001522 peripheral dimer interface [polypeptide binding]; other site 646529001523 core dimer interface [polypeptide binding]; other site 646529001524 L10 interface [polypeptide binding]; other site 646529001525 L11 interface [polypeptide binding]; other site 646529001526 putative EF-Tu interaction site [polypeptide binding]; other site 646529001527 putative EF-G interaction site [polypeptide binding]; other site 646529001528 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 646529001529 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 646529001530 RPB12 interaction site [polypeptide binding]; other site 646529001531 RPB1 interaction site [polypeptide binding]; other site 646529001532 RPB10 interaction site [polypeptide binding]; other site 646529001533 RPB11 interaction site [polypeptide binding]; other site 646529001534 RPB3 interaction site [polypeptide binding]; other site 646529001535 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 646529001536 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 646529001537 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 646529001538 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 646529001539 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 646529001540 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 646529001541 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 646529001542 G-loop; other site 646529001543 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 646529001544 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 646529001545 DNA binding site [nucleotide binding] 646529001546 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 646529001547 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 646529001548 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 646529001549 S17 interaction site [polypeptide binding]; other site 646529001550 S8 interaction site; other site 646529001551 16S rRNA interaction site [nucleotide binding]; other site 646529001552 streptomycin interaction site [chemical binding]; other site 646529001553 23S rRNA interaction site [nucleotide binding]; other site 646529001554 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 646529001555 30S ribosomal protein S7; Validated; Region: PRK05302 646529001556 elongation factor G; Reviewed; Region: PRK00007 646529001557 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 646529001558 G1 box; other site 646529001559 putative GEF interaction site [polypeptide binding]; other site 646529001560 GTP/Mg2+ binding site [chemical binding]; other site 646529001561 Switch I region; other site 646529001562 G2 box; other site 646529001563 G3 box; other site 646529001564 Switch II region; other site 646529001565 G4 box; other site 646529001566 G5 box; other site 646529001567 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 646529001568 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 646529001569 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 646529001570 elongation factor Tu; Reviewed; Region: PRK00049 646529001571 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 646529001572 G1 box; other site 646529001573 GEF interaction site [polypeptide binding]; other site 646529001574 GTP/Mg2+ binding site [chemical binding]; other site 646529001575 Switch I region; other site 646529001576 G2 box; other site 646529001577 G3 box; other site 646529001578 Switch II region; other site 646529001579 G4 box; other site 646529001580 G5 box; other site 646529001581 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 646529001582 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 646529001583 Antibiotic Binding Site [chemical binding]; other site 646529001584 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 646529001585 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 646529001586 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 646529001587 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 646529001588 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 646529001589 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 646529001590 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 646529001591 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 646529001592 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 646529001593 putative translocon binding site; other site 646529001594 protein-rRNA interface [nucleotide binding]; other site 646529001595 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 646529001596 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 646529001597 G-X-X-G motif; other site 646529001598 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 646529001599 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 646529001600 23S rRNA interface [nucleotide binding]; other site 646529001601 5S rRNA interface [nucleotide binding]; other site 646529001602 putative antibiotic binding site [chemical binding]; other site 646529001603 L25 interface [polypeptide binding]; other site 646529001604 L27 interface [polypeptide binding]; other site 646529001605 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 646529001606 23S rRNA interface [nucleotide binding]; other site 646529001607 putative translocon interaction site; other site 646529001608 signal recognition particle (SRP54) interaction site; other site 646529001609 L23 interface [polypeptide binding]; other site 646529001610 trigger factor interaction site; other site 646529001611 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 646529001612 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 646529001613 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 646529001614 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 646529001615 RNA binding site [nucleotide binding]; other site 646529001616 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 646529001617 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 646529001618 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 646529001619 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 646529001620 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 646529001621 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 646529001622 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 646529001623 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 646529001624 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 646529001625 23S rRNA interface [nucleotide binding]; other site 646529001626 L21e interface [polypeptide binding]; other site 646529001627 5S rRNA interface [nucleotide binding]; other site 646529001628 L27 interface [polypeptide binding]; other site 646529001629 L5 interface [polypeptide binding]; other site 646529001630 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 646529001631 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 646529001632 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 646529001633 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 646529001634 23S rRNA binding site [nucleotide binding]; other site 646529001635 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 646529001636 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 646529001637 SecY translocase; Region: SecY; pfam00344 646529001638 adenylate kinase; Reviewed; Region: adk; PRK00279 646529001639 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 646529001640 AMP-binding site [chemical binding]; other site 646529001641 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 646529001642 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 646529001643 active site 646529001644 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 646529001645 rRNA binding site [nucleotide binding]; other site 646529001646 predicted 30S ribosome binding site; other site 646529001647 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 646529001648 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 646529001649 30S ribosomal protein S13; Region: bact_S13; TIGR03631 646529001650 30S ribosomal protein S11; Validated; Region: PRK05309 646529001651 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 646529001652 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 646529001653 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 646529001654 RNA binding surface [nucleotide binding]; other site 646529001655 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 646529001656 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 646529001657 alphaNTD - beta interaction site [polypeptide binding]; other site 646529001658 alphaNTD homodimer interface [polypeptide binding]; other site 646529001659 alphaNTD - beta' interaction site [polypeptide binding]; other site 646529001660 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 646529001661 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 646529001662 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 646529001663 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 646529001664 Walker A/P-loop; other site 646529001665 ATP binding site [chemical binding]; other site 646529001666 Q-loop/lid; other site 646529001667 ABC transporter signature motif; other site 646529001668 Walker B; other site 646529001669 D-loop; other site 646529001670 H-loop/switch region; other site 646529001671 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 646529001672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529001673 Walker A/P-loop; other site 646529001674 ATP binding site [chemical binding]; other site 646529001675 Q-loop/lid; other site 646529001676 ABC transporter signature motif; other site 646529001677 Walker B; other site 646529001678 D-loop; other site 646529001679 H-loop/switch region; other site 646529001680 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 646529001681 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 646529001682 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 646529001683 dimerization interface 3.5A [polypeptide binding]; other site 646529001684 active site 646529001685 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 646529001686 23S rRNA interface [nucleotide binding]; other site 646529001687 L3 interface [polypeptide binding]; other site 646529001688 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 646529001689 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 646529001690 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 646529001691 active site 646529001692 metal binding site [ion binding]; metal-binding site 646529001693 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 646529001694 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 646529001695 metal binding site [ion binding]; metal-binding site 646529001696 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 646529001697 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 646529001698 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 646529001699 heterotetramer interface [polypeptide binding]; other site 646529001700 active site pocket [active] 646529001701 cleavage site 646529001702 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 646529001703 feedback inhibition sensing region; other site 646529001704 homohexameric interface [polypeptide binding]; other site 646529001705 nucleotide binding site [chemical binding]; other site 646529001706 N-acetyl-L-glutamate binding site [chemical binding]; other site 646529001707 acetylornithine aminotransferase; Provisional; Region: PRK02627 646529001708 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 646529001709 inhibitor-cofactor binding pocket; inhibition site 646529001710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529001711 catalytic residue [active] 646529001712 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 646529001713 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 646529001714 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 646529001715 catalytic site [active] 646529001716 subunit interface [polypeptide binding]; other site 646529001717 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 646529001718 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 646529001719 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 646529001720 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 646529001721 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 646529001722 ATP-grasp domain; Region: ATP-grasp_4; cl17255 646529001723 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 646529001724 substrate binding site [chemical binding]; other site 646529001725 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 646529001726 Double zinc ribbon; Region: DZR; pfam12773 646529001727 ornithine carbamoyltransferase; Provisional; Region: PRK00779 646529001728 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 646529001729 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 646529001730 argininosuccinate synthase; Provisional; Region: PRK13820 646529001731 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 646529001732 ANP binding site [chemical binding]; other site 646529001733 Substrate Binding Site II [chemical binding]; other site 646529001734 Substrate Binding Site I [chemical binding]; other site 646529001735 argininosuccinate lyase; Provisional; Region: PRK00855 646529001736 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 646529001737 active sites [active] 646529001738 tetramer interface [polypeptide binding]; other site 646529001739 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 646529001740 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 646529001741 active site 646529001742 NAD synthetase; Provisional; Region: PRK13980 646529001743 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 646529001744 homodimer interface [polypeptide binding]; other site 646529001745 NAD binding pocket [chemical binding]; other site 646529001746 ATP binding pocket [chemical binding]; other site 646529001747 Mg binding site [ion binding]; other site 646529001748 active-site loop [active] 646529001749 Uncharacterized conserved protein [Function unknown]; Region: COG5663 646529001750 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 646529001751 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 646529001752 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 646529001753 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 646529001754 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 646529001755 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 646529001756 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 646529001757 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 646529001758 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 646529001759 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 646529001760 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 646529001761 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529001762 Zn2+ binding site [ion binding]; other site 646529001763 Mg2+ binding site [ion binding]; other site 646529001764 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529001765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529001766 metal binding site [ion binding]; metal-binding site 646529001767 active site 646529001768 I-site; other site 646529001769 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529001770 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529001771 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 646529001772 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529001773 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529001774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529001775 active site 646529001776 phosphorylation site [posttranslational modification] 646529001777 intermolecular recognition site; other site 646529001778 dimerization interface [polypeptide binding]; other site 646529001779 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529001780 DNA binding site [nucleotide binding] 646529001781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529001782 TPR motif; other site 646529001783 binding surface 646529001784 TPR repeat; Region: TPR_11; pfam13414 646529001785 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 646529001786 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 646529001787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529001788 active site 646529001789 phosphorylation site [posttranslational modification] 646529001790 intermolecular recognition site; other site 646529001791 dimerization interface [polypeptide binding]; other site 646529001792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529001793 Walker A motif; other site 646529001794 ATP binding site [chemical binding]; other site 646529001795 Walker B motif; other site 646529001796 arginine finger; other site 646529001797 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529001798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529001799 dimer interface [polypeptide binding]; other site 646529001800 phosphorylation site [posttranslational modification] 646529001801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529001802 ATP binding site [chemical binding]; other site 646529001803 Mg2+ binding site [ion binding]; other site 646529001804 G-X-G motif; other site 646529001805 High-affinity nickel-transport protein; Region: NicO; cl00964 646529001806 Chromate transporter; Region: Chromate_transp; pfam02417 646529001807 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 646529001808 Chromate transporter; Region: Chromate_transp; pfam02417 646529001809 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 646529001810 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 646529001811 Predicted transcriptional regulators [Transcription]; Region: COG1695 646529001812 Transcriptional regulator PadR-like family; Region: PadR; cl17335 646529001813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 646529001814 dimerization interface [polypeptide binding]; other site 646529001815 putative DNA binding site [nucleotide binding]; other site 646529001816 putative Zn2+ binding site [ion binding]; other site 646529001817 Chromate transporter; Region: Chromate_transp; pfam02417 646529001818 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 646529001819 Chromate transporter; Region: Chromate_transp; pfam02417 646529001820 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 646529001821 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 646529001822 active site turn [active] 646529001823 phosphorylation site [posttranslational modification] 646529001824 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 646529001825 Penicillinase repressor; Region: Pencillinase_R; cl17580 646529001826 Peptidase family M48; Region: Peptidase_M48; cl12018 646529001827 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 646529001828 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 646529001829 FtsX-like permease family; Region: FtsX; pfam02687 646529001830 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 646529001831 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 646529001832 Walker A/P-loop; other site 646529001833 ATP binding site [chemical binding]; other site 646529001834 Q-loop/lid; other site 646529001835 ABC transporter signature motif; other site 646529001836 Walker B; other site 646529001837 D-loop; other site 646529001838 H-loop/switch region; other site 646529001839 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 646529001840 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 646529001841 FtsX-like permease family; Region: FtsX; pfam02687 646529001842 Predicted membrane protein [Function unknown]; Region: COG2259 646529001843 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 646529001844 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 646529001845 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 646529001846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 646529001847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 646529001848 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 646529001849 putative dimerization interface [polypeptide binding]; other site 646529001850 Transcriptional regulator [Transcription]; Region: LysR; COG0583 646529001851 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 646529001852 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 646529001853 dimerization interface [polypeptide binding]; other site 646529001854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529001855 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529001856 putative substrate translocation pore; other site 646529001857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 646529001858 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 646529001859 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 646529001860 Nitrogen regulatory protein P-II; Region: P-II; smart00938 646529001861 Domain of unknown function DUF39; Region: DUF39; pfam01837 646529001862 NIL domain; Region: NIL; pfam09383 646529001863 4Fe-4S binding domain; Region: Fer4; pfam00037 646529001864 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 646529001865 4Fe-4S binding domain; Region: Fer4; cl02805 646529001866 hypothetical protein; Provisional; Region: PRK04334 646529001867 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 646529001868 putative metal binding site; other site 646529001869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529001870 binding surface 646529001871 TPR motif; other site 646529001872 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 646529001873 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 646529001874 active site 646529001875 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 646529001876 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 646529001877 putative metal binding site; other site 646529001878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529001879 binding surface 646529001880 TPR motif; other site 646529001881 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 646529001882 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 646529001883 putative metal binding site; other site 646529001884 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 646529001885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529001886 TPR motif; other site 646529001887 binding surface 646529001888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529001889 TPR motif; other site 646529001890 binding surface 646529001891 TPR repeat; Region: TPR_11; pfam13414 646529001892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529001893 binding surface 646529001894 TPR motif; other site 646529001895 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 646529001896 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 646529001897 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 646529001898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 646529001899 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 646529001900 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 646529001901 Uncharacterized conserved protein [Function unknown]; Region: COG3391 646529001902 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 646529001903 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 646529001904 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 646529001905 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 646529001906 putative homodimer interface [polypeptide binding]; other site 646529001907 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 646529001908 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 646529001909 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 646529001910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529001911 active site 646529001912 phosphorylation site [posttranslational modification] 646529001913 intermolecular recognition site; other site 646529001914 dimerization interface [polypeptide binding]; other site 646529001915 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 646529001916 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 646529001917 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 646529001918 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 646529001919 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 646529001920 NAD binding site [chemical binding]; other site 646529001921 substrate binding site [chemical binding]; other site 646529001922 active site 646529001923 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 646529001924 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 646529001925 Substrate binding site; other site 646529001926 metal-binding site 646529001927 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 646529001928 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 646529001929 NADP binding site [chemical binding]; other site 646529001930 active site 646529001931 putative substrate binding site [chemical binding]; other site 646529001932 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 646529001933 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 646529001934 NAD(P) binding site [chemical binding]; other site 646529001935 homodimer interface [polypeptide binding]; other site 646529001936 substrate binding site [chemical binding]; other site 646529001937 active site 646529001938 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 646529001939 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 646529001940 active site 646529001941 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 646529001942 active site 646529001943 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 646529001944 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 646529001945 active site 646529001946 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 646529001947 putative metal binding site; other site 646529001948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529001949 binding surface 646529001950 TPR motif; other site 646529001951 Methyltransferase domain; Region: Methyltransf_24; pfam13578 646529001952 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 646529001953 active site 646529001954 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 646529001955 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 646529001956 Methyltransferase domain; Region: Methyltransf_23; pfam13489 646529001957 Methyltransferase domain; Region: Methyltransf_11; pfam08241 646529001958 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 646529001959 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 646529001960 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 646529001961 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 646529001962 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; cl17747 646529001963 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 646529001964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 646529001965 NAD(P) binding site [chemical binding]; other site 646529001966 active site 646529001967 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 646529001968 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 646529001969 active site 646529001970 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 646529001971 Uncharacterized conserved protein [Function unknown]; Region: COG3391 646529001972 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 646529001973 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 646529001974 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 646529001975 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 646529001976 active site 646529001977 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 646529001978 homodimer interface [polypeptide binding]; other site 646529001979 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 646529001980 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 646529001981 Uncharacterized conserved protein [Function unknown]; Region: COG2006 646529001982 Domain of unknown function (DUF362); Region: DUF362; pfam04015 646529001983 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529001984 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529001985 Putative pyruvate format-lyase activating enzyme (DUF1786); Region: DUF1786; cl01638 646529001986 Uncharacterized conserved protein [Function unknown]; Region: COG1624 646529001987 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 646529001988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 646529001989 YbbR-like protein; Region: YbbR; pfam07949 646529001990 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 646529001991 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 646529001992 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 646529001993 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 646529001994 active site 646529001995 substrate binding site [chemical binding]; other site 646529001996 metal binding site [ion binding]; metal-binding site 646529001997 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 646529001998 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 646529001999 glutaminase active site [active] 646529002000 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 646529002001 dimer interface [polypeptide binding]; other site 646529002002 active site 646529002003 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 646529002004 dimer interface [polypeptide binding]; other site 646529002005 active site 646529002006 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 646529002007 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 646529002008 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 646529002009 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 646529002010 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 646529002011 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 646529002012 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 646529002013 Response regulator receiver domain; Region: Response_reg; pfam00072 646529002014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529002015 active site 646529002016 phosphorylation site [posttranslational modification] 646529002017 intermolecular recognition site; other site 646529002018 dimerization interface [polypeptide binding]; other site 646529002019 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 646529002020 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 646529002021 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 646529002022 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 646529002023 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 646529002024 dimer interface [polypeptide binding]; other site 646529002025 PYR/PP interface [polypeptide binding]; other site 646529002026 TPP binding site [chemical binding]; other site 646529002027 substrate binding site [chemical binding]; other site 646529002028 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 646529002029 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 646529002030 TPP-binding site [chemical binding]; other site 646529002031 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 646529002032 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 646529002033 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 646529002034 ligand binding site; other site 646529002035 oligomer interface; other site 646529002036 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 646529002037 dimer interface [polypeptide binding]; other site 646529002038 N-terminal domain interface [polypeptide binding]; other site 646529002039 sulfate 1 binding site; other site 646529002040 glycogen branching enzyme; Provisional; Region: PRK12313 646529002041 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 646529002042 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 646529002043 active site 646529002044 catalytic site [active] 646529002045 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 646529002046 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 646529002047 homodimer interface [polypeptide binding]; other site 646529002048 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 646529002049 active site pocket [active] 646529002050 glycogen synthase; Provisional; Region: glgA; PRK00654 646529002051 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 646529002052 ADP-binding pocket [chemical binding]; other site 646529002053 homodimer interface [polypeptide binding]; other site 646529002054 putative bifunctional 4-alpha-glucanotransferase/glycogen debranching enzyme; Provisional; Region: PRK14510 646529002055 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 646529002056 homodimer interface [polypeptide binding]; other site 646529002057 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 646529002058 active site 646529002059 homodimer interface [polypeptide binding]; other site 646529002060 catalytic site [active] 646529002061 4-alpha-glucanotransferase; Provisional; Region: PRK14508 646529002062 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 646529002063 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 646529002064 dimer interface [polypeptide binding]; other site 646529002065 catalytic triad [active] 646529002066 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 646529002067 dinuclear metal binding motif [ion binding]; other site 646529002068 PAS fold; Region: PAS_4; pfam08448 646529002069 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529002070 putative active site [active] 646529002071 heme pocket [chemical binding]; other site 646529002072 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 646529002073 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529002074 putative active site [active] 646529002075 heme pocket [chemical binding]; other site 646529002076 PAS domain S-box; Region: sensory_box; TIGR00229 646529002077 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529002078 putative active site [active] 646529002079 heme pocket [chemical binding]; other site 646529002080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529002081 dimer interface [polypeptide binding]; other site 646529002082 phosphorylation site [posttranslational modification] 646529002083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529002084 ATP binding site [chemical binding]; other site 646529002085 Mg2+ binding site [ion binding]; other site 646529002086 G-X-G motif; other site 646529002087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529002088 active site 646529002089 phosphorylation site [posttranslational modification] 646529002090 intermolecular recognition site; other site 646529002091 dimerization interface [polypeptide binding]; other site 646529002092 Response regulator receiver domain; Region: Response_reg; pfam00072 646529002093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529002094 active site 646529002095 phosphorylation site [posttranslational modification] 646529002096 intermolecular recognition site; other site 646529002097 dimerization interface [polypeptide binding]; other site 646529002098 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 646529002099 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 646529002100 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 646529002101 dimer interface [polypeptide binding]; other site 646529002102 phosphorylation site [posttranslational modification] 646529002103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529002104 ATP binding site [chemical binding]; other site 646529002105 Mg2+ binding site [ion binding]; other site 646529002106 G-X-G motif; other site 646529002107 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529002108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529002109 active site 646529002110 phosphorylation site [posttranslational modification] 646529002111 intermolecular recognition site; other site 646529002112 dimerization interface [polypeptide binding]; other site 646529002113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529002114 DNA binding site [nucleotide binding] 646529002115 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 646529002116 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 646529002117 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529002118 dimerization interface [polypeptide binding]; other site 646529002119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529002120 dimer interface [polypeptide binding]; other site 646529002121 phosphorylation site [posttranslational modification] 646529002122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529002123 ATP binding site [chemical binding]; other site 646529002124 Mg2+ binding site [ion binding]; other site 646529002125 G-X-G motif; other site 646529002126 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 646529002127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529002128 active site 646529002129 phosphorylation site [posttranslational modification] 646529002130 intermolecular recognition site; other site 646529002131 dimerization interface [polypeptide binding]; other site 646529002132 Response regulator receiver domain; Region: Response_reg; pfam00072 646529002133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529002134 active site 646529002135 phosphorylation site [posttranslational modification] 646529002136 intermolecular recognition site; other site 646529002137 dimerization interface [polypeptide binding]; other site 646529002138 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 646529002139 Ligand Binding Site [chemical binding]; other site 646529002140 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 646529002141 Ligand Binding Site [chemical binding]; other site 646529002142 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 646529002143 hypothetical protein; Provisional; Region: PRK11281 646529002144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529002145 dimerization interface [polypeptide binding]; other site 646529002146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529002147 dimer interface [polypeptide binding]; other site 646529002148 phosphorylation site [posttranslational modification] 646529002149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529002150 ATP binding site [chemical binding]; other site 646529002151 Mg2+ binding site [ion binding]; other site 646529002152 G-X-G motif; other site 646529002153 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529002154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529002155 active site 646529002156 phosphorylation site [posttranslational modification] 646529002157 intermolecular recognition site; other site 646529002158 dimerization interface [polypeptide binding]; other site 646529002159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529002160 DNA binding site [nucleotide binding] 646529002161 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 646529002162 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 646529002163 citrate lyase subunit gamma; Provisional; Region: PRK13253 646529002164 Response regulator receiver domain; Region: Response_reg; pfam00072 646529002165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529002166 active site 646529002167 phosphorylation site [posttranslational modification] 646529002168 intermolecular recognition site; other site 646529002169 dimerization interface [polypeptide binding]; other site 646529002170 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 646529002171 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 646529002172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529002173 Walker A/P-loop; other site 646529002174 ATP binding site [chemical binding]; other site 646529002175 Q-loop/lid; other site 646529002176 ABC transporter signature motif; other site 646529002177 Walker B; other site 646529002178 D-loop; other site 646529002179 H-loop/switch region; other site 646529002180 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 646529002181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529002182 Coenzyme A binding pocket [chemical binding]; other site 646529002183 Sulfatase; Region: Sulfatase; pfam00884 646529002184 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 646529002185 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 646529002186 Domain of unknown function DUF; Region: DUF204; pfam02659 646529002187 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 646529002188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529002189 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529002190 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529002191 dimerization interface [polypeptide binding]; other site 646529002192 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 646529002193 putative switch regulator; other site 646529002194 non-specific DNA interactions [nucleotide binding]; other site 646529002195 DNA binding site [nucleotide binding] 646529002196 sequence specific DNA binding site [nucleotide binding]; other site 646529002197 putative cAMP binding site [chemical binding]; other site 646529002198 Helix-turn-helix domain; Region: HTH_17; pfam12728 646529002199 PBP superfamily domain; Region: PBP_like; pfam12727 646529002200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529002201 dimer interface [polypeptide binding]; other site 646529002202 phosphorylation site [posttranslational modification] 646529002203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529002204 ATP binding site [chemical binding]; other site 646529002205 Mg2+ binding site [ion binding]; other site 646529002206 G-X-G motif; other site 646529002207 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529002208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529002209 active site 646529002210 phosphorylation site [posttranslational modification] 646529002211 intermolecular recognition site; other site 646529002212 dimerization interface [polypeptide binding]; other site 646529002213 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529002214 DNA binding site [nucleotide binding] 646529002215 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529002216 PAS domain; Region: PAS_9; pfam13426 646529002217 putative active site [active] 646529002218 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 646529002219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529002220 Walker A motif; other site 646529002221 ATP binding site [chemical binding]; other site 646529002222 Walker B motif; other site 646529002223 arginine finger; other site 646529002224 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529002225 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 646529002226 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 646529002227 CoA-ligase; Region: Ligase_CoA; pfam00549 646529002228 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 646529002229 CoA binding domain; Region: CoA_binding; smart00881 646529002230 CoA-ligase; Region: Ligase_CoA; pfam00549 646529002231 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 646529002232 peroxiredoxin; Region: AhpC; TIGR03137 646529002233 decamer (pentamer of dimers) interface [polypeptide binding]; other site 646529002234 catalytic triad [active] 646529002235 dimer interface [polypeptide binding]; other site 646529002236 peroxidatic and resolving cysteines [active] 646529002237 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 646529002238 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 646529002239 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 646529002240 substrate binding site [chemical binding]; other site 646529002241 oxyanion hole (OAH) forming residues; other site 646529002242 trimer interface [polypeptide binding]; other site 646529002243 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 646529002244 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 646529002245 active site 646529002246 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 646529002247 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 646529002248 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 646529002249 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 646529002250 putative acyltransferase; Provisional; Region: PRK05790 646529002251 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 646529002252 dimer interface [polypeptide binding]; other site 646529002253 active site 646529002254 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 646529002255 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 646529002256 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 646529002257 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 646529002258 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 646529002259 active site 646529002260 putative acyltransferase; Provisional; Region: PRK05790 646529002261 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 646529002262 dimer interface [polypeptide binding]; other site 646529002263 active site 646529002264 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 646529002265 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 646529002266 active site 646529002267 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 646529002268 PAS domain; Region: PAS_9; pfam13426 646529002269 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 646529002270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529002271 Walker A motif; other site 646529002272 ATP binding site [chemical binding]; other site 646529002273 Walker B motif; other site 646529002274 arginine finger; other site 646529002275 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529002276 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 646529002277 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 646529002278 active site 646529002279 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 646529002280 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 646529002281 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 646529002282 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 646529002283 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 646529002284 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 646529002285 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 646529002286 substrate binding site [chemical binding]; other site 646529002287 oxyanion hole (OAH) forming residues; other site 646529002288 trimer interface [polypeptide binding]; other site 646529002289 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 646529002290 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 646529002291 dimer interface [polypeptide binding]; other site 646529002292 active site 646529002293 YGGT family; Region: YGGT; pfam02325 646529002294 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 646529002295 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 646529002296 ACS interaction site; other site 646529002297 CODH interaction site; other site 646529002298 cubane metal cluster (B-cluster) [ion binding]; other site 646529002299 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 646529002300 Spore germination protein; Region: Spore_permease; cl17796 646529002301 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 646529002302 Homoserine O-succinyltransferase; Region: HTS; pfam04204 646529002303 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 646529002304 proposed active site lysine [active] 646529002305 conserved cys residue [active] 646529002306 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 646529002307 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 646529002308 homodimer interface [polypeptide binding]; other site 646529002309 substrate-cofactor binding pocket; other site 646529002310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529002311 catalytic residue [active] 646529002312 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 646529002313 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 646529002314 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 646529002315 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 646529002316 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 646529002317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 646529002318 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 646529002319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 646529002320 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 646529002321 dimerization interface [polypeptide binding]; other site 646529002322 putative DNA binding site [nucleotide binding]; other site 646529002323 putative Zn2+ binding site [ion binding]; other site 646529002324 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529002325 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 646529002326 putative active site [active] 646529002327 heme pocket [chemical binding]; other site 646529002328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529002329 PAS domain; Region: PAS_9; pfam13426 646529002330 putative active site [active] 646529002331 heme pocket [chemical binding]; other site 646529002332 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529002333 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529002334 metal binding site [ion binding]; metal-binding site 646529002335 active site 646529002336 I-site; other site 646529002337 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 646529002338 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 646529002339 Ferritin-like domain; Region: Ferritin; pfam00210 646529002340 ferroxidase diiron center [ion binding]; other site 646529002341 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 646529002342 Ligand Binding Site [chemical binding]; other site 646529002343 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 646529002344 homotrimer interaction site [polypeptide binding]; other site 646529002345 putative active site [active] 646529002346 hypothetical protein; Provisional; Region: PRK03881 646529002347 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 646529002348 AMMECR1; Region: AMMECR1; pfam01871 646529002349 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 646529002350 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529002351 FeS/SAM binding site; other site 646529002352 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 646529002353 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 646529002354 transmembrane helices; other site 646529002355 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 646529002356 dimanganese center [ion binding]; other site 646529002357 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 646529002358 MarR family; Region: MarR; pfam01047 646529002359 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 646529002360 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 646529002361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529002362 Walker A/P-loop; other site 646529002363 ATP binding site [chemical binding]; other site 646529002364 Q-loop/lid; other site 646529002365 ABC transporter signature motif; other site 646529002366 Walker B; other site 646529002367 D-loop; other site 646529002368 H-loop/switch region; other site 646529002369 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 646529002370 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 646529002371 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 646529002372 Walker A/P-loop; other site 646529002373 ATP binding site [chemical binding]; other site 646529002374 Q-loop/lid; other site 646529002375 ABC transporter signature motif; other site 646529002376 Walker B; other site 646529002377 D-loop; other site 646529002378 H-loop/switch region; other site 646529002379 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 646529002380 homodimer interaction site [polypeptide binding]; other site 646529002381 cofactor binding site; other site 646529002382 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 646529002383 active site 1 [active] 646529002384 dimer interface [polypeptide binding]; other site 646529002385 hexamer interface [polypeptide binding]; other site 646529002386 active site 2 [active] 646529002387 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 646529002388 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 646529002389 DNA binding site [nucleotide binding] 646529002390 active site 646529002391 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 646529002392 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 646529002393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529002394 FeS/SAM binding site; other site 646529002395 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 646529002396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529002397 DNA-binding site [nucleotide binding]; DNA binding site 646529002398 TrkA-C domain; Region: TrkA_C; pfam02080 646529002399 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 646529002400 Uncharacterized conserved protein [Function unknown]; Region: COG0062 646529002401 putative carbohydrate kinase; Provisional; Region: PRK10565 646529002402 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 646529002403 putative substrate binding site [chemical binding]; other site 646529002404 putative ATP binding site [chemical binding]; other site 646529002405 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 646529002406 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 646529002407 active site 646529002408 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 646529002409 dimer interface [polypeptide binding]; other site 646529002410 substrate binding site [chemical binding]; other site 646529002411 catalytic residues [active] 646529002412 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 646529002413 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 646529002414 Cl- selectivity filter; other site 646529002415 Cl- binding residues [ion binding]; other site 646529002416 pore gating glutamate residue; other site 646529002417 dimer interface [polypeptide binding]; other site 646529002418 H+/Cl- coupling transport residue; other site 646529002419 TrkA-C domain; Region: TrkA_C; pfam02080 646529002420 L-lactate permease; Region: Lactate_perm; cl00701 646529002421 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 646529002422 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 646529002423 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 646529002424 active site 646529002425 dimer interface [polypeptide binding]; other site 646529002426 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 646529002427 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 646529002428 active site 646529002429 FMN binding site [chemical binding]; other site 646529002430 substrate binding site [chemical binding]; other site 646529002431 3Fe-4S cluster binding site [ion binding]; other site 646529002432 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 646529002433 domain interface; other site 646529002434 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 646529002435 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 646529002436 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 646529002437 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 646529002438 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 646529002439 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 646529002440 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 646529002441 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 646529002442 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 646529002443 catalytic triad [active] 646529002444 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 646529002445 PemK-like protein; Region: PemK; pfam02452 646529002446 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 646529002447 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 646529002448 catalytic triad [active] 646529002449 Short C-terminal domain; Region: SHOCT; pfam09851 646529002450 Predicted membrane protein [Function unknown]; Region: COG3462 646529002451 Short C-terminal domain; Region: SHOCT; pfam09851 646529002452 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 646529002453 phosphodiesterase YaeI; Provisional; Region: PRK11340 646529002454 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 646529002455 putative active site [active] 646529002456 putative metal binding site [ion binding]; other site 646529002457 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 646529002458 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 646529002459 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 646529002460 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 646529002461 Transcriptional regulators [Transcription]; Region: FadR; COG2186 646529002462 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529002463 DNA-binding site [nucleotide binding]; DNA binding site 646529002464 FCD domain; Region: FCD; pfam07729 646529002465 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 646529002466 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 646529002467 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 646529002468 Walker A/P-loop; other site 646529002469 ATP binding site [chemical binding]; other site 646529002470 Q-loop/lid; other site 646529002471 ABC transporter signature motif; other site 646529002472 Walker B; other site 646529002473 D-loop; other site 646529002474 H-loop/switch region; other site 646529002475 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 646529002476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529002477 dimer interface [polypeptide binding]; other site 646529002478 conserved gate region; other site 646529002479 putative PBP binding loops; other site 646529002480 ABC-ATPase subunit interface; other site 646529002481 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 646529002482 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 646529002483 substrate binding pocket [chemical binding]; other site 646529002484 membrane-bound complex binding site; other site 646529002485 hinge residues; other site 646529002486 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529002487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529002488 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 646529002489 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 646529002490 HlyD family secretion protein; Region: HlyD_3; pfam13437 646529002491 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 646529002492 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 646529002493 Walker A/P-loop; other site 646529002494 ATP binding site [chemical binding]; other site 646529002495 Q-loop/lid; other site 646529002496 ABC transporter signature motif; other site 646529002497 Walker B; other site 646529002498 D-loop; other site 646529002499 H-loop/switch region; other site 646529002500 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 646529002501 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 646529002502 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 646529002503 active site 646529002504 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 646529002505 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 646529002506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529002507 homodimer interface [polypeptide binding]; other site 646529002508 catalytic residue [active] 646529002509 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 646529002510 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 646529002511 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 646529002512 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 646529002513 RNA binding site [nucleotide binding]; other site 646529002514 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 646529002515 EamA-like transporter family; Region: EamA; pfam00892 646529002516 EamA-like transporter family; Region: EamA; pfam00892 646529002517 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 646529002518 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 646529002519 active site 646529002520 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 646529002521 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 646529002522 Glycoprotease family; Region: Peptidase_M22; pfam00814 646529002523 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 646529002524 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529002525 Coenzyme A binding pocket [chemical binding]; other site 646529002526 UGMP family protein; Validated; Region: PRK09604 646529002527 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 646529002528 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 646529002529 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 646529002530 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 646529002531 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 646529002532 putative dimer interface [polypeptide binding]; other site 646529002533 [2Fe-2S] cluster binding site [ion binding]; other site 646529002534 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 646529002535 dimer interface [polypeptide binding]; other site 646529002536 [2Fe-2S] cluster binding site [ion binding]; other site 646529002537 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 646529002538 SLBB domain; Region: SLBB; pfam10531 646529002539 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 646529002540 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 646529002541 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529002542 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 646529002543 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 646529002544 catalytic loop [active] 646529002545 iron binding site [ion binding]; other site 646529002546 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 646529002547 4Fe-4S binding domain; Region: Fer4; pfam00037 646529002548 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 646529002549 [4Fe-4S] binding site [ion binding]; other site 646529002550 molybdopterin cofactor binding site; other site 646529002551 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 646529002552 molybdopterin cofactor binding site; other site 646529002553 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 646529002554 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 646529002555 GTP binding site; other site 646529002556 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 646529002557 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 646529002558 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529002559 FeS/SAM binding site; other site 646529002560 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 646529002561 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 646529002562 trimer interface [polypeptide binding]; other site 646529002563 dimer interface [polypeptide binding]; other site 646529002564 putative active site [active] 646529002565 MOSC domain; Region: MOSC; pfam03473 646529002566 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 646529002567 MPT binding site; other site 646529002568 trimer interface [polypeptide binding]; other site 646529002569 LabA_like proteins; Region: LabA_like; cd06167 646529002570 putative metal binding site [ion binding]; other site 646529002571 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 646529002572 oligomerisation interface [polypeptide binding]; other site 646529002573 mobile loop; other site 646529002574 roof hairpin; other site 646529002575 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 646529002576 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 646529002577 ring oligomerisation interface [polypeptide binding]; other site 646529002578 ATP/Mg binding site [chemical binding]; other site 646529002579 stacking interactions; other site 646529002580 hinge regions; other site 646529002581 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 646529002582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529002583 non-specific DNA binding site [nucleotide binding]; other site 646529002584 salt bridge; other site 646529002585 sequence-specific DNA binding site [nucleotide binding]; other site 646529002586 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 646529002587 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 646529002588 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 646529002589 DNA binding residues [nucleotide binding] 646529002590 putative dimer interface [polypeptide binding]; other site 646529002591 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 646529002592 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 646529002593 DinB family; Region: DinB; cl17821 646529002594 Uncharacterized conserved protein [Function unknown]; Region: COG1633 646529002595 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 646529002596 diiron binding motif [ion binding]; other site 646529002597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529002598 dimer interface [polypeptide binding]; other site 646529002599 phosphorylation site [posttranslational modification] 646529002600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529002601 ATP binding site [chemical binding]; other site 646529002602 Mg2+ binding site [ion binding]; other site 646529002603 G-X-G motif; other site 646529002604 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529002605 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529002606 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529002607 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 646529002608 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 646529002609 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 646529002610 Transcriptional regulators [Transcription]; Region: FadR; COG2186 646529002611 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529002612 DNA-binding site [nucleotide binding]; DNA binding site 646529002613 FCD domain; Region: FCD; pfam07729 646529002614 Cupin domain; Region: Cupin_2; pfam07883 646529002615 hypothetical protein; Provisional; Region: PRK11171 646529002616 Cupin domain; Region: Cupin_2; pfam07883 646529002617 allantoate amidohydrolase; Reviewed; Region: PRK09290 646529002618 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 646529002619 active site 646529002620 metal binding site [ion binding]; metal-binding site 646529002621 dimer interface [polypeptide binding]; other site 646529002622 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 646529002623 allantoinase; Region: allantoinase; TIGR03178 646529002624 active site 646529002625 allantoinase; Provisional; Region: PRK06189 646529002626 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 646529002627 active site 646529002628 nucleobase-cation-symport-1 (NCS1) transporter Mhp1-like; solute-binding domain; Region: SLC-NCS1sbd_Mhp1-like; cd11483 646529002629 Na binding site [ion binding]; other site 646529002630 substrate binding site [chemical binding]; other site 646529002631 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 646529002632 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 646529002633 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 646529002634 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 646529002635 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 646529002636 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 646529002637 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 646529002638 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 646529002639 active site 646529002640 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 646529002641 Sensory domain found in PocR; Region: PocR; pfam10114 646529002642 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 646529002643 PAS domain S-box; Region: sensory_box; TIGR00229 646529002644 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 646529002645 putative active site [active] 646529002646 heme pocket [chemical binding]; other site 646529002647 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529002648 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529002649 metal binding site [ion binding]; metal-binding site 646529002650 active site 646529002651 I-site; other site 646529002652 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 646529002653 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529002654 Zn2+ binding site [ion binding]; other site 646529002655 Mg2+ binding site [ion binding]; other site 646529002656 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 646529002657 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 646529002658 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 646529002659 generic binding surface II; other site 646529002660 generic binding surface I; other site 646529002661 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 646529002662 active site 646529002663 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 646529002664 active site 646529002665 catalytic site [active] 646529002666 substrate binding site [chemical binding]; other site 646529002667 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 646529002668 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 646529002669 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529002670 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529002671 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 646529002672 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 646529002673 HlyD family secretion protein; Region: HlyD_3; pfam13437 646529002674 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 646529002675 drug efflux system protein MdtG; Provisional; Region: PRK09874 646529002676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529002677 putative substrate translocation pore; other site 646529002678 Predicted transcriptional regulators [Transcription]; Region: COG1733 646529002679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 646529002680 putative DNA binding site [nucleotide binding]; other site 646529002681 dimerization interface [polypeptide binding]; other site 646529002682 putative Zn2+ binding site [ion binding]; other site 646529002683 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 646529002684 PAS domain; Region: PAS_9; pfam13426 646529002685 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 646529002686 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529002687 dimer interface [polypeptide binding]; other site 646529002688 phosphorylation site [posttranslational modification] 646529002689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529002690 ATP binding site [chemical binding]; other site 646529002691 Mg2+ binding site [ion binding]; other site 646529002692 G-X-G motif; other site 646529002693 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 646529002694 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529002695 PAS domain; Region: PAS_9; pfam13426 646529002696 putative active site [active] 646529002697 heme pocket [chemical binding]; other site 646529002698 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 646529002699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529002700 dimer interface [polypeptide binding]; other site 646529002701 phosphorylation site [posttranslational modification] 646529002702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529002703 ATP binding site [chemical binding]; other site 646529002704 Mg2+ binding site [ion binding]; other site 646529002705 G-X-G motif; other site 646529002706 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 646529002707 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529002708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529002709 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 646529002710 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 646529002711 putative binding surface; other site 646529002712 active site 646529002713 P2 response regulator binding domain; Region: P2; pfam07194 646529002714 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 646529002715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529002716 ATP binding site [chemical binding]; other site 646529002717 Mg2+ binding site [ion binding]; other site 646529002718 G-X-G motif; other site 646529002719 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 646529002720 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 646529002721 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 646529002722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529002723 dimerization interface [polypeptide binding]; other site 646529002724 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 646529002725 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529002726 dimer interface [polypeptide binding]; other site 646529002727 putative CheW interface [polypeptide binding]; other site 646529002728 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 646529002729 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 646529002730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529002731 S-adenosylmethionine binding site [chemical binding]; other site 646529002732 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 646529002733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529002734 active site 646529002735 phosphorylation site [posttranslational modification] 646529002736 intermolecular recognition site; other site 646529002737 dimerization interface [polypeptide binding]; other site 646529002738 CheB methylesterase; Region: CheB_methylest; pfam01339 646529002739 CheD chemotactic sensory transduction; Region: CheD; cl00810 646529002740 Response regulator receiver domain; Region: Response_reg; pfam00072 646529002741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529002742 active site 646529002743 phosphorylation site [posttranslational modification] 646529002744 intermolecular recognition site; other site 646529002745 dimerization interface [polypeptide binding]; other site 646529002746 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 646529002747 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 646529002748 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 646529002749 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 646529002750 putative NADH binding site [chemical binding]; other site 646529002751 putative active site [active] 646529002752 nudix motif; other site 646529002753 putative metal binding site [ion binding]; other site 646529002754 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 646529002755 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 646529002756 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 646529002757 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 646529002758 Glutamine amidotransferase class-I; Region: GATase; pfam00117 646529002759 glutamine binding [chemical binding]; other site 646529002760 catalytic triad [active] 646529002761 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 646529002762 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 646529002763 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 646529002764 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 646529002765 active site 646529002766 ribulose/triose binding site [chemical binding]; other site 646529002767 phosphate binding site [ion binding]; other site 646529002768 substrate (anthranilate) binding pocket [chemical binding]; other site 646529002769 product (indole) binding pocket [chemical binding]; other site 646529002770 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 646529002771 active site 646529002772 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 646529002773 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 646529002774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529002775 catalytic residue [active] 646529002776 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 646529002777 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 646529002778 substrate binding site [chemical binding]; other site 646529002779 active site 646529002780 catalytic residues [active] 646529002781 heterodimer interface [polypeptide binding]; other site 646529002782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529002783 putative substrate translocation pore; other site 646529002784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529002785 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 646529002786 active site 646529002787 GMP synthase; Reviewed; Region: guaA; PRK00074 646529002788 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 646529002789 AMP/PPi binding site [chemical binding]; other site 646529002790 candidate oxyanion hole; other site 646529002791 catalytic triad [active] 646529002792 potential glutamine specificity residues [chemical binding]; other site 646529002793 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 646529002794 ATP Binding subdomain [chemical binding]; other site 646529002795 Ligand Binding sites [chemical binding]; other site 646529002796 Dimerization subdomain; other site 646529002797 Predicted membrane protein [Function unknown]; Region: COG3462 646529002798 Short C-terminal domain; Region: SHOCT; pfam09851 646529002799 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 646529002800 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 646529002801 active site 646529002802 catalytic site [active] 646529002803 substrate binding site [chemical binding]; other site 646529002804 AIR carboxylase; Region: AIRC; pfam00731 646529002805 adenylosuccinate lyase; Provisional; Region: PRK07492 646529002806 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 646529002807 tetramer interface [polypeptide binding]; other site 646529002808 active site 646529002809 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 646529002810 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 646529002811 ATP binding site [chemical binding]; other site 646529002812 active site 646529002813 substrate binding site [chemical binding]; other site 646529002814 amidophosphoribosyltransferase; Provisional; Region: PRK05793 646529002815 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 646529002816 active site 646529002817 tetramer interface [polypeptide binding]; other site 646529002818 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 646529002819 active site 646529002820 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 646529002821 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 646529002822 dimerization interface [polypeptide binding]; other site 646529002823 putative ATP binding site [chemical binding]; other site 646529002824 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 646529002825 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 646529002826 active site 646529002827 substrate binding site [chemical binding]; other site 646529002828 cosubstrate binding site; other site 646529002829 catalytic site [active] 646529002830 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 646529002831 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 646529002832 purine monophosphate binding site [chemical binding]; other site 646529002833 dimer interface [polypeptide binding]; other site 646529002834 putative catalytic residues [active] 646529002835 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 646529002836 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 646529002837 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 646529002838 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 646529002839 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 646529002840 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 646529002841 Uncharacterized conserved protein [Function unknown]; Region: COG1633 646529002842 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 646529002843 dinuclear metal binding motif [ion binding]; other site 646529002844 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 646529002845 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 646529002846 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 646529002847 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529002848 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529002849 metal binding site [ion binding]; metal-binding site 646529002850 active site 646529002851 I-site; other site 646529002852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529002853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529002854 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 646529002855 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 646529002856 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529002857 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529002858 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529002859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 646529002860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529002861 dimerization interface [polypeptide binding]; other site 646529002862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529002863 dimer interface [polypeptide binding]; other site 646529002864 phosphorylation site [posttranslational modification] 646529002865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529002866 ATP binding site [chemical binding]; other site 646529002867 Mg2+ binding site [ion binding]; other site 646529002868 G-X-G motif; other site 646529002869 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529002870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529002871 active site 646529002872 phosphorylation site [posttranslational modification] 646529002873 intermolecular recognition site; other site 646529002874 dimerization interface [polypeptide binding]; other site 646529002875 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529002876 DNA binding site [nucleotide binding] 646529002877 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 646529002878 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 646529002879 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 646529002880 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 646529002881 iron-sulfur cluster [ion binding]; other site 646529002882 [2Fe-2S] cluster binding site [ion binding]; other site 646529002883 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 646529002884 cytochrome b; Provisional; Region: CYTB; MTH00191 646529002885 interchain domain interface [polypeptide binding]; other site 646529002886 intrachain domain interface; other site 646529002887 heme bH binding site [chemical binding]; other site 646529002888 Qi binding site; other site 646529002889 heme bL binding site [chemical binding]; other site 646529002890 Qo binding site; other site 646529002891 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 646529002892 Qo binding site; other site 646529002893 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 646529002894 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 646529002895 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 646529002896 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 646529002897 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 646529002898 active site 646529002899 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 646529002900 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 646529002901 active site 646529002902 ATP binding site [chemical binding]; other site 646529002903 substrate binding site [chemical binding]; other site 646529002904 activation loop (A-loop); other site 646529002905 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 646529002906 Nitrogen regulatory protein P-II; Region: P-II; smart00938 646529002907 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 646529002908 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 646529002909 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 646529002910 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 646529002911 Soluble P-type ATPase [General function prediction only]; Region: COG4087 646529002912 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 646529002913 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 646529002914 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 646529002915 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 646529002916 Ligand Binding Site [chemical binding]; other site 646529002917 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 646529002918 GAF domain; Region: GAF_3; pfam13492 646529002919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529002920 dimer interface [polypeptide binding]; other site 646529002921 phosphorylation site [posttranslational modification] 646529002922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529002923 ATP binding site [chemical binding]; other site 646529002924 Mg2+ binding site [ion binding]; other site 646529002925 G-X-G motif; other site 646529002926 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529002927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529002928 active site 646529002929 phosphorylation site [posttranslational modification] 646529002930 intermolecular recognition site; other site 646529002931 dimerization interface [polypeptide binding]; other site 646529002932 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529002933 DNA binding site [nucleotide binding] 646529002934 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 646529002935 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 646529002936 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 646529002937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529002938 active site 646529002939 phosphorylation site [posttranslational modification] 646529002940 intermolecular recognition site; other site 646529002941 dimerization interface [polypeptide binding]; other site 646529002942 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529002943 DNA binding site [nucleotide binding] 646529002944 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 646529002945 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 646529002946 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 646529002947 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 646529002948 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 646529002949 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529002950 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 646529002951 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529002952 HTH domain; Region: HTH_11; pfam08279 646529002953 Predicted transcriptional regulator [Transcription]; Region: COG2378 646529002954 WYL domain; Region: WYL; pfam13280 646529002955 Predicted transcriptional regulator [Transcription]; Region: COG2378 646529002956 WYL domain; Region: WYL; pfam13280 646529002957 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 646529002958 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 646529002959 generic binding surface I; other site 646529002960 generic binding surface II; other site 646529002961 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529002962 Zn2+ binding site [ion binding]; other site 646529002963 Mg2+ binding site [ion binding]; other site 646529002964 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 646529002965 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529002966 PAS domain; Region: PAS_9; pfam13426 646529002967 putative active site [active] 646529002968 heme pocket [chemical binding]; other site 646529002969 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 646529002970 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 646529002971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529002972 dimer interface [polypeptide binding]; other site 646529002973 phosphorylation site [posttranslational modification] 646529002974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529002975 ATP binding site [chemical binding]; other site 646529002976 Mg2+ binding site [ion binding]; other site 646529002977 G-X-G motif; other site 646529002978 Trp repressor protein; Region: Trp_repressor; cl17266 646529002979 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 646529002980 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 646529002981 dimer interface [polypeptide binding]; other site 646529002982 motif 1; other site 646529002983 active site 646529002984 motif 2; other site 646529002985 motif 3; other site 646529002986 6-phosphofructokinase; Provisional; Region: PRK03202 646529002987 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 646529002988 active site 646529002989 ADP/pyrophosphate binding site [chemical binding]; other site 646529002990 dimerization interface [polypeptide binding]; other site 646529002991 allosteric effector site; other site 646529002992 fructose-1,6-bisphosphate binding site; other site 646529002993 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 646529002994 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 646529002995 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 646529002996 histidinol dehydrogenase; Region: hisD; TIGR00069 646529002997 NAD binding site [chemical binding]; other site 646529002998 dimerization interface [polypeptide binding]; other site 646529002999 product binding site; other site 646529003000 substrate binding site [chemical binding]; other site 646529003001 zinc binding site [ion binding]; other site 646529003002 catalytic residues [active] 646529003003 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 646529003004 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 646529003005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529003006 homodimer interface [polypeptide binding]; other site 646529003007 catalytic residue [active] 646529003008 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 646529003009 putative active site pocket [active] 646529003010 4-fold oligomerization interface [polypeptide binding]; other site 646529003011 metal binding residues [ion binding]; metal-binding site 646529003012 3-fold/trimer interface [polypeptide binding]; other site 646529003013 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 646529003014 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 646529003015 putative active site [active] 646529003016 oxyanion strand; other site 646529003017 catalytic triad [active] 646529003018 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 646529003019 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 646529003020 catalytic residues [active] 646529003021 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 646529003022 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 646529003023 substrate binding site [chemical binding]; other site 646529003024 glutamase interaction surface [polypeptide binding]; other site 646529003025 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 646529003026 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 646529003027 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 646529003028 metal binding site [ion binding]; metal-binding site 646529003029 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 646529003030 putative active site [active] 646529003031 putative CoA binding site [chemical binding]; other site 646529003032 nudix motif; other site 646529003033 metal binding site [ion binding]; metal-binding site 646529003034 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 646529003035 active site 646529003036 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 646529003037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529003038 Coenzyme A binding pocket [chemical binding]; other site 646529003039 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529003040 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 646529003041 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529003042 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 646529003043 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 646529003044 active site 646529003045 Zn binding site [ion binding]; other site 646529003046 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 646529003047 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 646529003048 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 646529003049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529003050 homodimer interface [polypeptide binding]; other site 646529003051 catalytic residue [active] 646529003052 aspartate aminotransferase; Provisional; Region: PRK05764 646529003053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 646529003054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529003055 homodimer interface [polypeptide binding]; other site 646529003056 catalytic residue [active] 646529003057 Cytochrome c; Region: Cytochrom_C; pfam00034 646529003058 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 646529003059 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 646529003060 D-pathway; other site 646529003061 Low-spin heme binding site [chemical binding]; other site 646529003062 Putative water exit pathway; other site 646529003063 Binuclear center (active site) [active] 646529003064 K-pathway; other site 646529003065 Putative proton exit pathway; other site 646529003066 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 646529003067 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 646529003068 active site 646529003069 FMN binding site [chemical binding]; other site 646529003070 substrate binding site [chemical binding]; other site 646529003071 3Fe-4S cluster binding site [ion binding]; other site 646529003072 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 646529003073 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 646529003074 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 646529003075 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 646529003076 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 646529003077 inhibitor-cofactor binding pocket; inhibition site 646529003078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529003079 catalytic residue [active] 646529003080 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 646529003081 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 646529003082 inhibitor-cofactor binding pocket; inhibition site 646529003083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529003084 catalytic residue [active] 646529003085 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 646529003086 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 646529003087 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 646529003088 active site 646529003089 P-loop; other site 646529003090 phosphorylation site [posttranslational modification] 646529003091 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 646529003092 PRD domain; Region: PRD; pfam00874 646529003093 PRD domain; Region: PRD; pfam00874 646529003094 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 646529003095 active site 646529003096 P-loop; other site 646529003097 phosphorylation site [posttranslational modification] 646529003098 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 646529003099 active site 646529003100 phosphorylation site [posttranslational modification] 646529003101 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 646529003102 active site 646529003103 phosphorylation site [posttranslational modification] 646529003104 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 646529003105 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 646529003106 putative substrate binding site [chemical binding]; other site 646529003107 putative ATP binding site [chemical binding]; other site 646529003108 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 646529003109 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 646529003110 putative NAD(P) binding site [chemical binding]; other site 646529003111 catalytic Zn binding site [ion binding]; other site 646529003112 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 646529003113 dimerization domain swap beta strand [polypeptide binding]; other site 646529003114 regulatory protein interface [polypeptide binding]; other site 646529003115 active site 646529003116 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 646529003117 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 646529003118 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 646529003119 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 646529003120 HPr kinase/phosphorylase; Provisional; Region: PRK05428 646529003121 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 646529003122 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 646529003123 Hpr binding site; other site 646529003124 active site 646529003125 homohexamer subunit interaction site [polypeptide binding]; other site 646529003126 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 646529003127 HTH domain; Region: HTH_11; pfam08279 646529003128 3H domain; Region: 3H; pfam02829 646529003129 benzoate transport; Region: 2A0115; TIGR00895 646529003130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529003131 putative substrate translocation pore; other site 646529003132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529003133 glyoxylate reductase; Reviewed; Region: PRK13243 646529003134 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 646529003135 dimerization interface [polypeptide binding]; other site 646529003136 ligand binding site [chemical binding]; other site 646529003137 NADP binding site [chemical binding]; other site 646529003138 catalytic site [active] 646529003139 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 646529003140 catalytic residues [active] 646529003141 Domain of unknown function (DUF202); Region: DUF202; cl09954 646529003142 calcium/proton exchanger (cax); Region: cax; TIGR00378 646529003143 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 646529003144 FAD binding domain; Region: FAD_binding_4; pfam01565 646529003145 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 646529003146 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 646529003147 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529003148 Cysteine-rich domain; Region: CCG; pfam02754 646529003149 Cysteine-rich domain; Region: CCG; pfam02754 646529003150 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 646529003151 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 646529003152 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 646529003153 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 646529003154 Walker A/P-loop; other site 646529003155 ATP binding site [chemical binding]; other site 646529003156 Q-loop/lid; other site 646529003157 ABC transporter signature motif; other site 646529003158 Walker B; other site 646529003159 D-loop; other site 646529003160 H-loop/switch region; other site 646529003161 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 646529003162 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 646529003163 Walker A/P-loop; other site 646529003164 ATP binding site [chemical binding]; other site 646529003165 Q-loop/lid; other site 646529003166 ABC transporter signature motif; other site 646529003167 Walker B; other site 646529003168 D-loop; other site 646529003169 H-loop/switch region; other site 646529003170 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 646529003171 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 646529003172 TM-ABC transporter signature motif; other site 646529003173 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 646529003174 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 646529003175 TM-ABC transporter signature motif; other site 646529003176 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 646529003177 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 646529003178 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 646529003179 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 646529003180 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 646529003181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529003182 Walker A/P-loop; other site 646529003183 ATP binding site [chemical binding]; other site 646529003184 Q-loop/lid; other site 646529003185 ABC transporter signature motif; other site 646529003186 Walker B; other site 646529003187 D-loop; other site 646529003188 H-loop/switch region; other site 646529003189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 646529003190 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 646529003191 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 646529003192 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 646529003193 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 646529003194 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 646529003195 protein binding site [polypeptide binding]; other site 646529003196 glycogen branching enzyme; Provisional; Region: PRK12313 646529003197 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 646529003198 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 646529003199 active site 646529003200 catalytic site [active] 646529003201 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 646529003202 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 646529003203 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 646529003204 active site pocket [active] 646529003205 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 646529003206 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 646529003207 ligand binding site; other site 646529003208 oligomer interface; other site 646529003209 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 646529003210 dimer interface [polypeptide binding]; other site 646529003211 N-terminal domain interface [polypeptide binding]; other site 646529003212 sulfate 1 binding site; other site 646529003213 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 646529003214 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 646529003215 ligand binding site; other site 646529003216 oligomer interface; other site 646529003217 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 646529003218 dimer interface [polypeptide binding]; other site 646529003219 N-terminal domain interface [polypeptide binding]; other site 646529003220 sulfate 1 binding site; other site 646529003221 glycogen synthase; Provisional; Region: glgA; PRK00654 646529003222 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 646529003223 ADP-binding pocket [chemical binding]; other site 646529003224 homodimer interface [polypeptide binding]; other site 646529003225 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 646529003226 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 646529003227 DNA binding residues [nucleotide binding] 646529003228 dimer interface [polypeptide binding]; other site 646529003229 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 646529003230 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 646529003231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 646529003232 motif II; other site 646529003233 Uncharacterized conserved protein [Function unknown]; Region: COG1434 646529003234 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 646529003235 putative active site [active] 646529003236 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 646529003237 dimer interface [polypeptide binding]; other site 646529003238 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 646529003239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529003240 non-specific DNA binding site [nucleotide binding]; other site 646529003241 salt bridge; other site 646529003242 sequence-specific DNA binding site [nucleotide binding]; other site 646529003243 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 646529003244 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 646529003245 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 646529003246 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 646529003247 MarR family; Region: MarR; pfam01047 646529003248 Nitroreductase [Energy production and conversion]; Region: NfnB; COG0778 646529003249 FMN binding site [chemical binding]; other site 646529003250 dimer interface [polypeptide binding]; other site 646529003251 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 646529003252 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529003253 FeS/SAM binding site; other site 646529003254 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 646529003255 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 646529003256 Part of AAA domain; Region: AAA_19; pfam13245 646529003257 Family description; Region: UvrD_C_2; pfam13538 646529003258 Phosphopantetheine attachment site; Region: PP-binding; cl09936 646529003259 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 646529003260 active site 646529003261 catalytic triad [active] 646529003262 oxyanion hole [active] 646529003263 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 646529003264 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 646529003265 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 646529003266 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529003267 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 646529003268 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 646529003269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529003270 homodimer interface [polypeptide binding]; other site 646529003271 catalytic residue [active] 646529003272 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 646529003273 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 646529003274 catalytic residues [active] 646529003275 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 646529003276 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 646529003277 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 646529003278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529003279 Coenzyme A binding pocket [chemical binding]; other site 646529003280 NRDE protein; Region: NRDE; pfam05742 646529003281 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 646529003282 Transcriptional regulators [Transcription]; Region: MarR; COG1846 646529003283 MarR family; Region: MarR_2; pfam12802 646529003284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 646529003285 dimerization interface [polypeptide binding]; other site 646529003286 putative DNA binding site [nucleotide binding]; other site 646529003287 putative Zn2+ binding site [ion binding]; other site 646529003288 Predicted integral membrane protein [Function unknown]; Region: COG5658 646529003289 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 646529003290 SdpI/YhfL protein family; Region: SdpI; pfam13630 646529003291 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 646529003292 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 646529003293 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 646529003294 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 646529003295 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 646529003296 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 646529003297 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 646529003298 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 646529003299 homodimer interface [polypeptide binding]; other site 646529003300 metal binding site [ion binding]; metal-binding site 646529003301 Transposase domain (DUF772); Region: DUF772; pfam05598 646529003302 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 646529003303 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 646529003304 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 646529003305 ligand binding site [chemical binding]; other site 646529003306 CHASE3 domain; Region: CHASE3; cl05000 646529003307 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 646529003308 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529003309 dimerization interface [polypeptide binding]; other site 646529003310 Histidine kinase; Region: His_kinase; pfam06580 646529003311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529003312 ATP binding site [chemical binding]; other site 646529003313 Mg2+ binding site [ion binding]; other site 646529003314 G-X-G motif; other site 646529003315 Response regulator receiver domain; Region: Response_reg; pfam00072 646529003316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529003317 active site 646529003318 phosphorylation site [posttranslational modification] 646529003319 intermolecular recognition site; other site 646529003320 dimerization interface [polypeptide binding]; other site 646529003321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 646529003322 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 646529003323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 646529003324 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 646529003325 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 646529003326 putative ligand binding site [chemical binding]; other site 646529003327 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 646529003328 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 646529003329 putative ligand binding site [chemical binding]; other site 646529003330 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 646529003331 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 646529003332 Walker A/P-loop; other site 646529003333 ATP binding site [chemical binding]; other site 646529003334 Q-loop/lid; other site 646529003335 ABC transporter signature motif; other site 646529003336 Walker B; other site 646529003337 D-loop; other site 646529003338 H-loop/switch region; other site 646529003339 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 646529003340 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 646529003341 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 646529003342 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 646529003343 TM-ABC transporter signature motif; other site 646529003344 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 646529003345 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 646529003346 nucleotide binding site [chemical binding]; other site 646529003347 xylose isomerase; Provisional; Region: PRK05474 646529003348 xylose isomerase; Region: xylose_isom_A; TIGR02630 646529003349 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 646529003350 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 646529003351 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 646529003352 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 646529003353 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 646529003354 N- and C-terminal domain interface [polypeptide binding]; other site 646529003355 D-xylulose kinase; Region: XylB; TIGR01312 646529003356 active site 646529003357 MgATP binding site [chemical binding]; other site 646529003358 catalytic site [active] 646529003359 metal binding site [ion binding]; metal-binding site 646529003360 xylulose binding site [chemical binding]; other site 646529003361 homodimer interface [polypeptide binding]; other site 646529003362 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 646529003363 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 646529003364 NAD binding site [chemical binding]; other site 646529003365 homodimer interface [polypeptide binding]; other site 646529003366 active site 646529003367 substrate binding site [chemical binding]; other site 646529003368 EDD domain protein, DegV family; Region: DegV; TIGR00762 646529003369 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 646529003370 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 646529003371 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 646529003372 dimer interface [polypeptide binding]; other site 646529003373 active site 646529003374 galactokinase; Provisional; Region: PRK05322 646529003375 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 646529003376 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 646529003377 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 646529003378 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 646529003379 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 646529003380 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 646529003381 active site 646529003382 Transcriptional regulators [Transcription]; Region: MarR; COG1846 646529003383 MarR family; Region: MarR_2; pfam12802 646529003384 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 646529003385 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 646529003386 nucleotide binding site [chemical binding]; other site 646529003387 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 646529003388 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 646529003389 putative ligand binding site [chemical binding]; other site 646529003390 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 646529003391 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 646529003392 Walker A/P-loop; other site 646529003393 ATP binding site [chemical binding]; other site 646529003394 Q-loop/lid; other site 646529003395 ABC transporter signature motif; other site 646529003396 Walker B; other site 646529003397 D-loop; other site 646529003398 H-loop/switch region; other site 646529003399 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 646529003400 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 646529003401 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 646529003402 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 646529003403 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 646529003404 TM-ABC transporter signature motif; other site 646529003405 ribulokinase; Provisional; Region: PRK04123 646529003406 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 646529003407 N- and C-terminal domain interface [polypeptide binding]; other site 646529003408 active site 646529003409 MgATP binding site [chemical binding]; other site 646529003410 catalytic site [active] 646529003411 metal binding site [ion binding]; metal-binding site 646529003412 carbohydrate binding site [chemical binding]; other site 646529003413 homodimer interface [polypeptide binding]; other site 646529003414 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 646529003415 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 646529003416 intersubunit interface [polypeptide binding]; other site 646529003417 active site 646529003418 Zn2+ binding site [ion binding]; other site 646529003419 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 646529003420 active site 646529003421 metal binding site [ion binding]; metal-binding site 646529003422 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 646529003423 L-arabinose isomerase; Provisional; Region: PRK02929 646529003424 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 646529003425 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 646529003426 trimer interface [polypeptide binding]; other site 646529003427 putative substrate binding site [chemical binding]; other site 646529003428 putative metal binding site [ion binding]; other site 646529003429 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 646529003430 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 646529003431 active site 646529003432 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 646529003433 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 646529003434 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529003435 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529003436 DNA binding residues [nucleotide binding] 646529003437 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 646529003438 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 646529003439 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 646529003440 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 646529003441 PHP domain; Region: PHP; pfam02811 646529003442 active site 646529003443 PHP-associated; Region: PHP_C; pfam13263 646529003444 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 646529003445 4Fe-4S binding domain; Region: Fer4; pfam00037 646529003446 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 646529003447 4Fe-4S binding domain; Region: Fer4; cl02805 646529003448 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 646529003449 active site 2 [active] 646529003450 active site 1 [active] 646529003451 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 646529003452 active site 2 [active] 646529003453 active site 1 [active] 646529003454 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 646529003455 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 646529003456 substrate binding site [chemical binding]; other site 646529003457 oxyanion hole (OAH) forming residues; other site 646529003458 trimer interface [polypeptide binding]; other site 646529003459 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 646529003460 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 646529003461 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 646529003462 acyl-CoA synthetase; Validated; Region: PRK06178 646529003463 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 646529003464 acyl-activating enzyme (AAE) consensus motif; other site 646529003465 putative AMP binding site [chemical binding]; other site 646529003466 putative active site [active] 646529003467 putative CoA binding site [chemical binding]; other site 646529003468 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 646529003469 PGAP1-like protein; Region: PGAP1; pfam07819 646529003470 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 646529003471 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 646529003472 substrate binding site [chemical binding]; other site 646529003473 oxyanion hole (OAH) forming residues; other site 646529003474 trimer interface [polypeptide binding]; other site 646529003475 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529003476 PAS domain; Region: PAS_9; pfam13426 646529003477 putative active site [active] 646529003478 heme pocket [chemical binding]; other site 646529003479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529003480 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 646529003481 Walker A motif; other site 646529003482 ATP binding site [chemical binding]; other site 646529003483 Walker B motif; other site 646529003484 arginine finger; other site 646529003485 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 646529003486 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: COG2248 646529003487 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 646529003488 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 646529003489 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 646529003490 acyl-activating enzyme (AAE) consensus motif; other site 646529003491 putative AMP binding site [chemical binding]; other site 646529003492 putative active site [active] 646529003493 putative CoA binding site [chemical binding]; other site 646529003494 Uncharacterized conserved protein [Function unknown]; Region: COG2006 646529003495 Domain of unknown function (DUF362); Region: DUF362; pfam04015 646529003496 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 646529003497 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 646529003498 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 646529003499 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 646529003500 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 646529003501 acyl-activating enzyme (AAE) consensus motif; other site 646529003502 putative AMP binding site [chemical binding]; other site 646529003503 putative active site [active] 646529003504 putative CoA binding site [chemical binding]; other site 646529003505 Uncharacterized conserved protein [Function unknown]; Region: COG2461 646529003506 Family of unknown function (DUF438); Region: DUF438; pfam04282 646529003507 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 646529003508 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 646529003509 active site 646529003510 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 646529003511 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 646529003512 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 646529003513 DEAD_2; Region: DEAD_2; pfam06733 646529003514 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 646529003515 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 646529003516 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 646529003517 minor groove reading motif; other site 646529003518 helix-hairpin-helix signature motif; other site 646529003519 substrate binding pocket [chemical binding]; other site 646529003520 active site 646529003521 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 646529003522 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 646529003523 DNA binding and oxoG recognition site [nucleotide binding] 646529003524 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 646529003525 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 646529003526 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 646529003527 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 646529003528 FMN binding site [chemical binding]; other site 646529003529 dimer interface [polypeptide binding]; other site 646529003530 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 646529003531 nucleotide binding site/active site [active] 646529003532 HIT family signature motif; other site 646529003533 catalytic residue [active] 646529003534 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529003535 HAMP domain; Region: HAMP; pfam00672 646529003536 dimerization interface [polypeptide binding]; other site 646529003537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529003538 dimer interface [polypeptide binding]; other site 646529003539 phosphorylation site [posttranslational modification] 646529003540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529003541 ATP binding site [chemical binding]; other site 646529003542 Mg2+ binding site [ion binding]; other site 646529003543 G-X-G motif; other site 646529003544 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529003545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529003546 active site 646529003547 phosphorylation site [posttranslational modification] 646529003548 intermolecular recognition site; other site 646529003549 dimerization interface [polypeptide binding]; other site 646529003550 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529003551 DNA binding site [nucleotide binding] 646529003552 2-isopropylmalate synthase; Validated; Region: PRK00915 646529003553 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 646529003554 active site 646529003555 catalytic residues [active] 646529003556 metal binding site [ion binding]; metal-binding site 646529003557 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 646529003558 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 646529003559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 646529003560 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 646529003561 putative dimerization interface [polypeptide binding]; other site 646529003562 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 646529003563 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 646529003564 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 646529003565 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 646529003566 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 646529003567 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 646529003568 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 646529003569 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 646529003570 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 646529003571 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 646529003572 Predicted transcriptional regulators [Transcription]; Region: COG1733 646529003573 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 646529003574 Hemerythrin; Region: Hemerythrin; cd12107 646529003575 Fe binding site [ion binding]; other site 646529003576 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 646529003577 Predicted transcriptional regulators [Transcription]; Region: COG1733 646529003578 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 646529003579 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529003580 Zn2+ binding site [ion binding]; other site 646529003581 Mg2+ binding site [ion binding]; other site 646529003582 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 646529003583 PilZ domain; Region: PilZ; pfam07238 646529003584 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 646529003585 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 646529003586 active site 646529003587 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 646529003588 Glyco_18 domain; Region: Glyco_18; smart00636 646529003589 active site 646529003590 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 646529003591 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529003592 Ferredoxin [Energy production and conversion]; Region: COG1146 646529003593 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 646529003594 Peptidase family U32; Region: Peptidase_U32; pfam01136 646529003595 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529003596 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529003597 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529003598 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529003599 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529003600 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529003601 HD domain; Region: HD_3; cl17350 646529003602 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 646529003603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529003604 FeS/SAM binding site; other site 646529003605 EDD domain protein, DegV family; Region: DegV; TIGR00762 646529003606 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 646529003607 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 646529003608 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 646529003609 Membrane protein of unknown function; Region: DUF360; pfam04020 646529003610 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529003611 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529003612 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529003613 Bacterial SH3 domain; Region: SH3_3; pfam08239 646529003614 Bacterial SH3 domain; Region: SH3_3; pfam08239 646529003615 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 646529003616 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 646529003617 active site 646529003618 metal binding site [ion binding]; metal-binding site 646529003619 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 646529003620 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 646529003621 PYR/PP interface [polypeptide binding]; other site 646529003622 dimer interface [polypeptide binding]; other site 646529003623 TPP binding site [chemical binding]; other site 646529003624 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 646529003625 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 646529003626 TPP-binding site [chemical binding]; other site 646529003627 dimer interface [polypeptide binding]; other site 646529003628 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 646529003629 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 646529003630 putative valine binding site [chemical binding]; other site 646529003631 dimer interface [polypeptide binding]; other site 646529003632 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 646529003633 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 646529003634 active site 646529003635 catalytic residues [active] 646529003636 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529003637 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529003638 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529003639 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 646529003640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529003641 putative substrate translocation pore; other site 646529003642 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 646529003643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529003644 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529003645 DNA binding residues [nucleotide binding] 646529003646 Putative zinc-finger; Region: zf-HC2; pfam13490 646529003647 Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039 646529003648 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 646529003649 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 646529003650 Walker A/P-loop; other site 646529003651 ATP binding site [chemical binding]; other site 646529003652 Q-loop/lid; other site 646529003653 ABC transporter signature motif; other site 646529003654 Walker B; other site 646529003655 D-loop; other site 646529003656 H-loop/switch region; other site 646529003657 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 646529003658 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 646529003659 active site 646529003660 putative substrate binding pocket [chemical binding]; other site 646529003661 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 646529003662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529003663 putative substrate translocation pore; other site 646529003664 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 646529003665 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 646529003666 Prephenate dehydratase; Region: PDT; pfam00800 646529003667 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 646529003668 putative L-Phe binding site [chemical binding]; other site 646529003669 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 646529003670 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529003671 non-specific DNA binding site [nucleotide binding]; other site 646529003672 salt bridge; other site 646529003673 sequence-specific DNA binding site [nucleotide binding]; other site 646529003674 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 646529003675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529003676 active site 646529003677 phosphorylation site [posttranslational modification] 646529003678 intermolecular recognition site; other site 646529003679 dimerization interface [polypeptide binding]; other site 646529003680 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 646529003681 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 646529003682 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 646529003683 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 646529003684 putative active site; other site 646529003685 catalytic triad [active] 646529003686 putative dimer interface [polypeptide binding]; other site 646529003687 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 646529003688 Nitrogen regulatory protein P-II; Region: P-II; smart00938 646529003689 Transcriptional regulators [Transcription]; Region: PurR; COG1609 646529003690 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 646529003691 DNA binding site [nucleotide binding] 646529003692 domain linker motif; other site 646529003693 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 646529003694 putative dimerization interface [polypeptide binding]; other site 646529003695 putative ligand binding site [chemical binding]; other site 646529003696 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 646529003697 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 646529003698 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 646529003699 DctM-like transporters; Region: DctM; pfam06808 646529003700 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 646529003701 putative oxidoreductase; Provisional; Region: PRK11579 646529003702 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 646529003703 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 646529003704 Glucuronate isomerase; Region: UxaC; pfam02614 646529003705 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 646529003706 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 646529003707 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 646529003708 active site 646529003709 intersubunit interface [polypeptide binding]; other site 646529003710 catalytic residue [active] 646529003711 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 646529003712 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 646529003713 substrate binding site [chemical binding]; other site 646529003714 ATP binding site [chemical binding]; other site 646529003715 altronate oxidoreductase; Provisional; Region: PRK03643 646529003716 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 646529003717 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 646529003718 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 646529003719 galactarate dehydratase; Region: galactar-dH20; TIGR03248 646529003720 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 646529003721 SWIM zinc finger; Region: SWIM; pfam04434 646529003722 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 646529003723 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 646529003724 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 646529003725 ATP binding site [chemical binding]; other site 646529003726 putative Mg++ binding site [ion binding]; other site 646529003727 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529003728 nucleotide binding region [chemical binding]; other site 646529003729 ATP-binding site [chemical binding]; other site 646529003730 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 646529003731 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 646529003732 active site 646529003733 catalytic tetrad [active] 646529003734 aspartate kinase; Validated; Region: PRK09181 646529003735 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 646529003736 nucleotide binding site [chemical binding]; other site 646529003737 substrate binding site [chemical binding]; other site 646529003738 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 646529003739 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 646529003740 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 646529003741 putative deacylase active site [active] 646529003742 DNA topoisomerase III; Provisional; Region: PRK07726 646529003743 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 646529003744 active site 646529003745 putative interdomain interaction site [polypeptide binding]; other site 646529003746 putative metal-binding site [ion binding]; other site 646529003747 putative nucleotide binding site [chemical binding]; other site 646529003748 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 646529003749 domain I; other site 646529003750 DNA binding groove [nucleotide binding] 646529003751 phosphate binding site [ion binding]; other site 646529003752 domain II; other site 646529003753 domain III; other site 646529003754 nucleotide binding site [chemical binding]; other site 646529003755 catalytic site [active] 646529003756 domain IV; other site 646529003757 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 646529003758 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 646529003759 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 646529003760 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 646529003761 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 646529003762 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 646529003763 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 646529003764 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 646529003765 ABC1 family; Region: ABC1; pfam03109 646529003766 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 646529003767 active site 646529003768 ATP binding site [chemical binding]; other site 646529003769 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 646529003770 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 646529003771 Walker A/P-loop; other site 646529003772 ATP binding site [chemical binding]; other site 646529003773 Q-loop/lid; other site 646529003774 ABC transporter signature motif; other site 646529003775 Walker B; other site 646529003776 D-loop; other site 646529003777 H-loop/switch region; other site 646529003778 Methyltransferase domain; Region: Methyltransf_31; pfam13847 646529003779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529003780 S-adenosylmethionine binding site [chemical binding]; other site 646529003781 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 646529003782 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 646529003783 dimerization interface [polypeptide binding]; other site 646529003784 ligand binding site [chemical binding]; other site 646529003785 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 646529003786 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 646529003787 TM-ABC transporter signature motif; other site 646529003788 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 646529003789 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 646529003790 TM-ABC transporter signature motif; other site 646529003791 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 646529003792 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 646529003793 Walker A/P-loop; other site 646529003794 ATP binding site [chemical binding]; other site 646529003795 Q-loop/lid; other site 646529003796 ABC transporter signature motif; other site 646529003797 Walker B; other site 646529003798 D-loop; other site 646529003799 H-loop/switch region; other site 646529003800 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 646529003801 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 646529003802 Walker A/P-loop; other site 646529003803 ATP binding site [chemical binding]; other site 646529003804 Q-loop/lid; other site 646529003805 ABC transporter signature motif; other site 646529003806 Walker B; other site 646529003807 D-loop; other site 646529003808 H-loop/switch region; other site 646529003809 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 646529003810 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 646529003811 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 646529003812 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529003813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529003814 FeS/SAM binding site; other site 646529003815 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 646529003816 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 646529003817 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 646529003818 FeS/SAM binding site; other site 646529003819 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 646529003820 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 646529003821 dimer interface [polypeptide binding]; other site 646529003822 active site 646529003823 glycine loop; other site 646529003824 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 646529003825 Proline racemase; Region: Pro_racemase; pfam05544 646529003826 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 646529003827 catalytic loop [active] 646529003828 iron binding site [ion binding]; other site 646529003829 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 646529003830 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 646529003831 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 646529003832 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 646529003833 hydroxyglutarate oxidase; Provisional; Region: PRK11728 646529003834 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 646529003835 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 646529003836 Glutamate binding site [chemical binding]; other site 646529003837 NAD binding site [chemical binding]; other site 646529003838 catalytic residues [active] 646529003839 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 646529003840 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 646529003841 PAS domain; Region: PAS; smart00091 646529003842 PAS domain; Region: PAS_9; pfam13426 646529003843 putative active site [active] 646529003844 heme pocket [chemical binding]; other site 646529003845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529003846 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 646529003847 Walker A motif; other site 646529003848 ATP binding site [chemical binding]; other site 646529003849 Walker B motif; other site 646529003850 arginine finger; other site 646529003851 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529003852 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 646529003853 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 646529003854 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 646529003855 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 646529003856 active site 646529003857 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 646529003858 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 646529003859 dimer interface [polypeptide binding]; other site 646529003860 acyl-activating enzyme (AAE) consensus motif; other site 646529003861 putative active site [active] 646529003862 AMP binding site [chemical binding]; other site 646529003863 putative CoA binding site [chemical binding]; other site 646529003864 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 646529003865 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 646529003866 dimer interface [polypeptide binding]; other site 646529003867 active site 646529003868 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 646529003869 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 646529003870 NAD binding site [chemical binding]; other site 646529003871 homodimer interface [polypeptide binding]; other site 646529003872 homotetramer interface [polypeptide binding]; other site 646529003873 active site 646529003874 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 646529003875 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529003876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529003877 putative active site [active] 646529003878 heme pocket [chemical binding]; other site 646529003879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529003880 Walker A motif; other site 646529003881 ATP binding site [chemical binding]; other site 646529003882 Walker B motif; other site 646529003883 arginine finger; other site 646529003884 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529003885 Probable zinc-binding domain; Region: zf-trcl; pfam13451 646529003886 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 646529003887 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 646529003888 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 646529003889 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 646529003890 ABC transporter; Region: ABC_tran_2; pfam12848 646529003891 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 646529003892 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 646529003893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529003894 Walker A motif; other site 646529003895 ATP binding site [chemical binding]; other site 646529003896 Walker B motif; other site 646529003897 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 646529003898 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 646529003899 Walker A/P-loop; other site 646529003900 ATP binding site [chemical binding]; other site 646529003901 Q-loop/lid; other site 646529003902 ABC transporter signature motif; other site 646529003903 Walker B; other site 646529003904 D-loop; other site 646529003905 H-loop/switch region; other site 646529003906 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529003907 dimerization interface [polypeptide binding]; other site 646529003908 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529003909 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 646529003910 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529003911 dimer interface [polypeptide binding]; other site 646529003912 putative CheW interface [polypeptide binding]; other site 646529003913 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 646529003914 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 646529003915 putative dimer interface [polypeptide binding]; other site 646529003916 putative anticodon binding site; other site 646529003917 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 646529003918 homodimer interface [polypeptide binding]; other site 646529003919 motif 1; other site 646529003920 motif 2; other site 646529003921 active site 646529003922 motif 3; other site 646529003923 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 646529003924 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529003925 DNA-binding site [nucleotide binding]; DNA binding site 646529003926 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 646529003927 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 646529003928 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 646529003929 B12 binding site [chemical binding]; other site 646529003930 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 646529003931 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 646529003932 substrate binding pocket [chemical binding]; other site 646529003933 dimer interface [polypeptide binding]; other site 646529003934 inhibitor binding site; inhibition site 646529003935 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 646529003936 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 646529003937 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 646529003938 B12 binding site [chemical binding]; other site 646529003939 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 646529003940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529003941 putative substrate translocation pore; other site 646529003942 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 646529003943 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 646529003944 Part of AAA domain; Region: AAA_19; pfam13245 646529003945 Family description; Region: UvrD_C_2; pfam13538 646529003946 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 646529003947 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 646529003948 DHHA2 domain; Region: DHHA2; pfam02833 646529003949 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 646529003950 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 646529003951 nucleotide binding pocket [chemical binding]; other site 646529003952 K-X-D-G motif; other site 646529003953 catalytic site [active] 646529003954 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 646529003955 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 646529003956 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 646529003957 Dimer interface [polypeptide binding]; other site 646529003958 BRCT sequence motif; other site 646529003959 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 646529003960 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 646529003961 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 646529003962 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 646529003963 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 646529003964 GatB domain; Region: GatB_Yqey; smart00845 646529003965 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 646529003966 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 646529003967 active site 646529003968 catalytic residues [active] 646529003969 metal binding site [ion binding]; metal-binding site 646529003970 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 646529003971 isocitrate dehydrogenase; Validated; Region: PRK06451 646529003972 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 646529003973 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 646529003974 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 646529003975 CAAX protease self-immunity; Region: Abi; pfam02517 646529003976 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 646529003977 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 646529003978 Walker A/P-loop; other site 646529003979 ATP binding site [chemical binding]; other site 646529003980 Q-loop/lid; other site 646529003981 ABC transporter signature motif; other site 646529003982 Walker B; other site 646529003983 D-loop; other site 646529003984 H-loop/switch region; other site 646529003985 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 646529003986 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 646529003987 TRAM domain; Region: TRAM; pfam01938 646529003988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529003989 S-adenosylmethionine binding site [chemical binding]; other site 646529003990 Virulence protein [General function prediction only]; Region: COG3943 646529003991 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 646529003992 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 646529003993 DEAD/DEAH box helicase; Region: DEAD; pfam00270 646529003994 ATP binding site [chemical binding]; other site 646529003995 putative Mg++ binding site [ion binding]; other site 646529003996 nucleotide binding region [chemical binding]; other site 646529003997 helicase superfamily c-terminal domain; Region: HELICc; smart00490 646529003998 ATP-binding site [chemical binding]; other site 646529003999 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 646529004000 Methyltransferase domain; Region: Methyltransf_26; pfam13659 646529004001 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 646529004002 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 646529004003 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 646529004004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 646529004005 ATP binding site [chemical binding]; other site 646529004006 putative Mg++ binding site [ion binding]; other site 646529004007 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 646529004008 nucleotide binding region [chemical binding]; other site 646529004009 ATP-binding site [chemical binding]; other site 646529004010 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 646529004011 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 646529004012 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 646529004013 Restriction endonuclease; Region: Mrr_cat; pfam04471 646529004014 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 646529004015 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 646529004016 Int/Topo IB signature motif; other site 646529004017 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 646529004018 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 646529004019 DNA methylase; Region: N6_N4_Mtase; cl17433 646529004020 Nitroreductase family; Region: Nitroreductase; pfam00881 646529004021 FMN binding site [chemical binding]; other site 646529004022 dimer interface [polypeptide binding]; other site 646529004023 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 646529004024 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529004025 dimer interface [polypeptide binding]; other site 646529004026 putative CheW interface [polypeptide binding]; other site 646529004027 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 646529004028 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 646529004029 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529004030 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529004031 metal binding site [ion binding]; metal-binding site 646529004032 active site 646529004033 I-site; other site 646529004034 Response regulator receiver domain; Region: Response_reg; pfam00072 646529004035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529004036 active site 646529004037 phosphorylation site [posttranslational modification] 646529004038 intermolecular recognition site; other site 646529004039 dimerization interface [polypeptide binding]; other site 646529004040 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 646529004041 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529004042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529004043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529004044 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529004045 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 646529004046 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 646529004047 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529004048 putative CheW interface [polypeptide binding]; other site 646529004049 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 646529004050 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 646529004051 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 646529004052 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 646529004053 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529004054 Zn2+ binding site [ion binding]; other site 646529004055 Mg2+ binding site [ion binding]; other site 646529004056 Trehalase; Region: Trehalase; cl17346 646529004057 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 646529004058 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529004059 Zn2+ binding site [ion binding]; other site 646529004060 Mg2+ binding site [ion binding]; other site 646529004061 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 646529004062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529004063 non-specific DNA binding site [nucleotide binding]; other site 646529004064 salt bridge; other site 646529004065 sequence-specific DNA binding site [nucleotide binding]; other site 646529004066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529004067 non-specific DNA binding site [nucleotide binding]; other site 646529004068 salt bridge; other site 646529004069 sequence-specific DNA binding site [nucleotide binding]; other site 646529004070 BRO family, N-terminal domain; Region: Bro-N; smart01040 646529004071 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 646529004072 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 646529004073 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 646529004074 ATP binding site [chemical binding]; other site 646529004075 putative Mg++ binding site [ion binding]; other site 646529004076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529004077 nucleotide binding region [chemical binding]; other site 646529004078 ATP-binding site [chemical binding]; other site 646529004079 VRR-NUC domain; Region: VRR_NUC; pfam08774 646529004080 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 646529004081 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 646529004082 AAA domain; Region: AAA_24; pfam13479 646529004083 Protein of unknown function (DUF669); Region: DUF669; pfam05037 646529004084 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 646529004085 active site 646529004086 metal-binding site 646529004087 D5 N terminal like; Region: D5_N; smart00885 646529004088 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 646529004089 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 646529004090 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 646529004091 active site 646529004092 Phage terminase, small subunit; Region: Terminase_4; cl01525 646529004093 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 646529004094 ParB-like nuclease domain; Region: ParB; smart00470 646529004095 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 646529004096 DNA methylase; Region: N6_N4_Mtase; pfam01555 646529004097 HNH endonuclease; Region: HNH_3; pfam13392 646529004098 AP2 domain; Region: AP2; pfam00847 646529004099 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 646529004100 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 646529004101 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 646529004102 Phage-related protein [Function unknown]; Region: COG4695 646529004103 Phage portal protein; Region: Phage_portal; pfam04860 646529004104 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 646529004105 oligomer interface [polypeptide binding]; other site 646529004106 Clp protease; Region: CLP_protease; pfam00574 646529004107 active site residues [active] 646529004108 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 646529004109 Phage capsid family; Region: Phage_capsid; pfam05065 646529004110 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 646529004111 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 646529004112 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 646529004113 oligomerization interface [polypeptide binding]; other site 646529004114 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 646529004115 TIGR02147 family protein; Region: Fsuc_second 646529004116 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 646529004117 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 646529004118 Phage XkdN-like protein; Region: XkdN; pfam08890 646529004119 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 646529004120 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 646529004121 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 646529004122 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 646529004123 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 646529004124 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 646529004125 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 646529004126 amidase catalytic site [active] 646529004127 Zn binding residues [ion binding]; other site 646529004128 substrate binding site [chemical binding]; other site 646529004129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529004130 active site 646529004131 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 646529004132 phosphorylation site [posttranslational modification] 646529004133 intermolecular recognition site; other site 646529004134 Response regulator receiver domain; Region: Response_reg; pfam00072 646529004135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529004136 active site 646529004137 phosphorylation site [posttranslational modification] 646529004138 intermolecular recognition site; other site 646529004139 dimerization interface [polypeptide binding]; other site 646529004140 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529004141 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529004142 metal binding site [ion binding]; metal-binding site 646529004143 active site 646529004144 I-site; other site 646529004145 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08115 646529004146 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 646529004147 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529004148 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529004149 DNA binding residues [nucleotide binding] 646529004150 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 646529004151 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 646529004152 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 646529004153 putative active site [active] 646529004154 metal binding site [ion binding]; metal-binding site 646529004155 Predicted membrane protein [Function unknown]; Region: COG2259 646529004156 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 646529004157 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 646529004158 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 646529004159 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 646529004160 catalytic residues [active] 646529004161 catalytic nucleophile [active] 646529004162 Recombinase; Region: Recombinase; pfam07508 646529004163 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 646529004164 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 646529004165 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 646529004166 catalytic residues [active] 646529004167 catalytic nucleophile [active] 646529004168 Recombinase; Region: Recombinase; pfam07508 646529004169 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 646529004170 YmaF family; Region: YmaF; pfam12788 646529004171 Iron permease FTR1 family; Region: FTR1; cl00475 646529004172 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 646529004173 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 646529004174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529004175 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 646529004176 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529004177 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 646529004178 DinB family; Region: DinB; cl17821 646529004179 hypothetical protein; Provisional; Region: PRK02237 646529004180 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 646529004181 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 646529004182 Domain of unknown function DUF; Region: DUF204; pfam02659 646529004183 phage shock protein A; Region: phageshock_pspA; TIGR02977 646529004184 Tim44-like domain; Region: Tim44; cl09208 646529004185 Ion channel; Region: Ion_trans_2; pfam07885 646529004186 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 646529004187 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 646529004188 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 646529004189 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 646529004190 catalytic residues [active] 646529004191 catalytic nucleophile [active] 646529004192 Recombinase; Region: Recombinase; pfam07508 646529004193 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 646529004194 Domain of unknown function (DUF955); Region: DUF955; pfam06114 646529004195 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 646529004196 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529004197 non-specific DNA binding site [nucleotide binding]; other site 646529004198 salt bridge; other site 646529004199 sequence-specific DNA binding site [nucleotide binding]; other site 646529004200 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529004201 non-specific DNA binding site [nucleotide binding]; other site 646529004202 salt bridge; other site 646529004203 sequence-specific DNA binding site [nucleotide binding]; other site 646529004204 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529004205 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 646529004206 DNA binding residues [nucleotide binding] 646529004207 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 646529004208 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 646529004209 active site 646529004210 metal binding site 1 [ion binding]; metal-binding site 646529004211 putative 5' ssDNA interaction site; other site 646529004212 metal binding site 3; metal-binding site 646529004213 metal binding site 2 [ion binding]; metal-binding site 646529004214 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 646529004215 putative DNA binding site [nucleotide binding]; other site 646529004216 putative metal binding site [ion binding]; other site 646529004217 Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; Region: COG5219 646529004218 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 646529004219 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 646529004220 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 646529004221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529004222 non-specific DNA binding site [nucleotide binding]; other site 646529004223 salt bridge; other site 646529004224 sequence-specific DNA binding site [nucleotide binding]; other site 646529004225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 646529004226 binding surface 646529004227 TPR motif; other site 646529004228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529004229 binding surface 646529004230 Tetratricopeptide repeat; Region: TPR_12; pfam13424 646529004231 TPR motif; other site 646529004232 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 646529004233 B12 binding site [chemical binding]; other site 646529004234 Radical SAM superfamily; Region: Radical_SAM; pfam04055 646529004235 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 646529004236 putative DNA binding site [nucleotide binding]; other site 646529004237 dimerization interface [polypeptide binding]; other site 646529004238 putative Zn2+ binding site [ion binding]; other site 646529004239 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 646529004240 H+ Antiporter protein; Region: 2A0121; TIGR00900 646529004241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529004242 putative substrate translocation pore; other site 646529004243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 646529004244 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 646529004245 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 646529004246 active site 646529004247 DNA binding site [nucleotide binding] 646529004248 Int/Topo IB signature motif; other site 646529004249 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 646529004250 active site 646529004251 NTP binding site [chemical binding]; other site 646529004252 metal binding triad [ion binding]; metal-binding site 646529004253 antibiotic binding site [chemical binding]; other site 646529004254 Pleckstrin homology-like domain; Region: PH-like; cl17171 646529004255 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529004256 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 646529004257 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529004258 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529004259 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 646529004260 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 646529004261 catalytic residues [active] 646529004262 catalytic nucleophile [active] 646529004263 Recombinase; Region: Recombinase; pfam07508 646529004264 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 646529004265 Recombinase; Region: Recombinase; pfam07508 646529004266 Staygreen protein; Region: Staygreen; pfam12638 646529004267 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 646529004268 Uncharacterized conserved protein [Function unknown]; Region: COG2155 646529004269 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 646529004270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529004271 Coenzyme A binding pocket [chemical binding]; other site 646529004272 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 646529004273 DsrE/DsrF-like family; Region: DrsE; cl00672 646529004274 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 646529004275 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 646529004276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 646529004277 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529004278 Zn2+ binding site [ion binding]; other site 646529004279 Mg2+ binding site [ion binding]; other site 646529004280 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 646529004281 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 646529004282 DNA binding residues [nucleotide binding] 646529004283 dimer interface [polypeptide binding]; other site 646529004284 Probable zinc-binding domain; Region: zf-trcl; pfam13451 646529004285 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 646529004286 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 646529004287 sulfite oxidase; Provisional; Region: PLN00177 646529004288 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 646529004289 Moco binding site; other site 646529004290 metal coordination site [ion binding]; other site 646529004291 dimerization interface [polypeptide binding]; other site 646529004292 Response regulator receiver domain; Region: Response_reg; pfam00072 646529004293 AAA domain; Region: AAA_31; pfam13614 646529004294 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 646529004295 P-loop; other site 646529004296 Magnesium ion binding site [ion binding]; other site 646529004297 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 646529004298 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 646529004299 Walker A motif; other site 646529004300 ATP binding site [chemical binding]; other site 646529004301 Walker B motif; other site 646529004302 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 646529004303 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 646529004304 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 646529004305 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 646529004306 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 646529004307 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 646529004308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529004309 AAA-like domain; Region: AAA_10; pfam12846 646529004310 Walker A motif; other site 646529004311 ATP binding site [chemical binding]; other site 646529004312 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 646529004313 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 646529004314 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 646529004315 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 646529004316 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 646529004317 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 646529004318 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 646529004319 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 646529004320 nucleotide binding site [chemical binding]; other site 646529004321 TIR domain; Region: TIR_2; pfam13676 646529004322 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529004323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529004324 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529004325 Protein kinase domain; Region: Pkinase; pfam00069 646529004326 Catalytic domain of Protein Kinases; Region: PKc; cd00180 646529004327 active site 646529004328 ATP binding site [chemical binding]; other site 646529004329 substrate binding site [chemical binding]; other site 646529004330 activation loop (A-loop); other site 646529004331 LabA_like proteins; Region: LabA_like; cd06167 646529004332 putative metal binding site [ion binding]; other site 646529004333 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 646529004334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529004335 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 646529004336 Coenzyme A binding pocket [chemical binding]; other site 646529004337 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 646529004338 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 646529004339 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 646529004340 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 646529004341 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 646529004342 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 646529004343 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 646529004344 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 646529004345 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 646529004346 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 646529004347 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 646529004348 manganese transport transcriptional regulator; Provisional; Region: PRK03902 646529004349 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 646529004350 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 646529004351 ykoK leader 646529004352 PRC-barrel domain; Region: PRC; pfam05239 646529004353 MgtE intracellular N domain; Region: MgtE_N; smart00924 646529004354 FOG: CBS domain [General function prediction only]; Region: COG0517 646529004355 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 646529004356 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 646529004357 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 646529004358 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 646529004359 FMN binding site [chemical binding]; other site 646529004360 dimer interface [polypeptide binding]; other site 646529004361 TIGR03987 family protein; Region: TIGR03987 646529004362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529004363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529004364 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 646529004365 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 646529004366 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 646529004367 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 646529004368 dimer interface [polypeptide binding]; other site 646529004369 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 646529004370 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 646529004371 dimer interface [polypeptide binding]; other site 646529004372 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 646529004373 Protein of unknown function (DUF975); Region: DUF975; cl10504 646529004374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 646529004375 binding surface 646529004376 TPR motif; other site 646529004377 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 646529004378 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 646529004379 FAD binding domain; Region: FAD_binding_4; pfam01565 646529004380 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529004381 Cysteine-rich domain; Region: CCG; pfam02754 646529004382 Cysteine-rich domain; Region: CCG; pfam02754 646529004383 Predicted permease; Region: DUF318; cl17795 646529004384 PAS domain S-box; Region: sensory_box; TIGR00229 646529004385 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529004386 PAS fold; Region: PAS_3; pfam08447 646529004387 putative active site [active] 646529004388 heme pocket [chemical binding]; other site 646529004389 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 646529004390 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 646529004391 Protein of unknown function (DUF998); Region: DUF998; pfam06197 646529004392 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 646529004393 putative deacylase active site [active] 646529004394 Protein of unknown function (DUF328); Region: DUF328; pfam03883 646529004395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529004396 Coenzyme A binding pocket [chemical binding]; other site 646529004397 thymidine kinase; Provisional; Region: PRK04296 646529004398 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 646529004399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529004400 Coenzyme A binding pocket [chemical binding]; other site 646529004401 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 646529004402 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 646529004403 dimer interface [polypeptide binding]; other site 646529004404 PYR/PP interface [polypeptide binding]; other site 646529004405 TPP binding site [chemical binding]; other site 646529004406 substrate binding site [chemical binding]; other site 646529004407 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 646529004408 TPP-binding site; other site 646529004409 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 646529004410 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 646529004411 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 646529004412 L-lactate permease; Region: Lactate_perm; cl00701 646529004413 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 646529004414 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 646529004415 acyl-activating enzyme (AAE) consensus motif; other site 646529004416 AMP binding site [chemical binding]; other site 646529004417 active site 646529004418 CoA binding site [chemical binding]; other site 646529004419 Transcriptional regulators [Transcription]; Region: GntR; COG1802 646529004420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529004421 DNA-binding site [nucleotide binding]; DNA binding site 646529004422 FCD domain; Region: FCD; pfam07729 646529004423 mannonate dehydratase; Provisional; Region: PRK03906 646529004424 mannonate dehydratase; Region: uxuA; TIGR00695 646529004425 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 646529004426 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 646529004427 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 646529004428 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 646529004429 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 646529004430 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 646529004431 Amino acid permease; Region: AA_permease_2; pfam13520 646529004432 cobalt transport protein CbiM; Validated; Region: PRK08319 646529004433 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 646529004434 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 646529004435 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 646529004436 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 646529004437 Walker A/P-loop; other site 646529004438 ATP binding site [chemical binding]; other site 646529004439 Q-loop/lid; other site 646529004440 ABC transporter signature motif; other site 646529004441 Walker B; other site 646529004442 D-loop; other site 646529004443 H-loop/switch region; other site 646529004444 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529004445 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529004446 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529004447 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 646529004448 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529004449 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529004450 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529004451 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 646529004452 YibE/F-like protein; Region: YibE_F; pfam07907 646529004453 YibE/F-like protein; Region: YibE_F; pfam07907 646529004454 manganese transport protein MntH; Reviewed; Region: PRK00701 646529004455 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 646529004456 manganese transport transcriptional regulator; Provisional; Region: PRK03902 646529004457 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 646529004458 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 646529004459 Transcriptional regulator [Transcription]; Region: LytR; COG1316 646529004460 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 646529004461 Domain of unknown function DUF; Region: DUF204; pfam02659 646529004462 phage shock protein A; Region: phageshock_pspA; TIGR02977 646529004463 Tim44-like domain; Region: Tim44; cl09208 646529004464 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 646529004465 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 646529004466 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 646529004467 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 646529004468 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 646529004469 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 646529004470 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529004471 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529004472 metal binding site [ion binding]; metal-binding site 646529004473 active site 646529004474 I-site; other site 646529004475 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 646529004476 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 646529004477 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 646529004478 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 646529004479 DXD motif; other site 646529004480 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 646529004481 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 646529004482 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 646529004483 Interdomain contacts; other site 646529004484 Cytokine receptor motif; other site 646529004485 Cache domain; Region: Cache_1; pfam02743 646529004486 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529004487 dimerization interface [polypeptide binding]; other site 646529004488 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 646529004489 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529004490 dimer interface [polypeptide binding]; other site 646529004491 putative CheW interface [polypeptide binding]; other site 646529004492 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 646529004493 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 646529004494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529004495 active site 646529004496 phosphorylation site [posttranslational modification] 646529004497 intermolecular recognition site; other site 646529004498 dimerization interface [polypeptide binding]; other site 646529004499 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 646529004500 Flagellar protein YcgR; Region: YcgR_2; pfam12945 646529004501 PilZ domain; Region: PilZ; pfam07238 646529004502 Cache domain; Region: Cache_1; pfam02743 646529004503 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 646529004504 dimerization interface [polypeptide binding]; other site 646529004505 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529004506 dimer interface [polypeptide binding]; other site 646529004507 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 646529004508 putative CheW interface [polypeptide binding]; other site 646529004509 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 646529004510 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 646529004511 Hexamer interface [polypeptide binding]; other site 646529004512 Hexagonal pore residue; other site 646529004513 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 646529004514 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 646529004515 Hexamer interface [polypeptide binding]; other site 646529004516 Hexagonal pore residue; other site 646529004517 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 646529004518 putative catalytic cysteine [active] 646529004519 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 646529004520 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 646529004521 dimer interface [polypeptide binding]; other site 646529004522 active site 646529004523 glycine loop; other site 646529004524 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 646529004525 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 646529004526 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 646529004527 putative hexamer interface [polypeptide binding]; other site 646529004528 putative hexagonal pore; other site 646529004529 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 646529004530 G1 box; other site 646529004531 GTP/Mg2+ binding site [chemical binding]; other site 646529004532 G2 box; other site 646529004533 Switch I region; other site 646529004534 G3 box; other site 646529004535 Switch II region; other site 646529004536 G4 box; other site 646529004537 G5 box; other site 646529004538 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 646529004539 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 646529004540 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 646529004541 nucleotide binding site [chemical binding]; other site 646529004542 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 646529004543 nucleotide binding site [chemical binding]; other site 646529004544 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 646529004545 Hexamer interface [polypeptide binding]; other site 646529004546 Hexagonal pore residue; other site 646529004547 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 646529004548 Hexamer/Pentamer interface [polypeptide binding]; other site 646529004549 central pore; other site 646529004550 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 646529004551 SLBB domain; Region: SLBB; pfam10531 646529004552 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 646529004553 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 646529004554 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 646529004555 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 646529004556 putative hexamer interface [polypeptide binding]; other site 646529004557 putative hexagonal pore; other site 646529004558 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 646529004559 putative hexamer interface [polypeptide binding]; other site 646529004560 putative hexagonal pore; other site 646529004561 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 646529004562 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 646529004563 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 646529004564 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 646529004565 Hexamer interface [polypeptide binding]; other site 646529004566 Hexagonal pore residue; other site 646529004567 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 646529004568 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 646529004569 putative catalytic cysteine [active] 646529004570 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 646529004571 Propanediol utilisation protein PduL; Region: PduL; pfam06130 646529004572 Propanediol utilisation protein PduL; Region: PduL; pfam06130 646529004573 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 646529004574 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 646529004575 Hexamer interface [polypeptide binding]; other site 646529004576 Putative hexagonal pore residue; other site 646529004577 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 646529004578 EamA-like transporter family; Region: EamA; cl17759 646529004579 Transcriptional regulator [Transcription]; Region: LysR; COG0583 646529004580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 646529004581 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 646529004582 dimerization interface [polypeptide binding]; other site 646529004583 benzoate transport; Region: 2A0115; TIGR00895 646529004584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529004585 putative substrate translocation pore; other site 646529004586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529004587 Uncharacterized conserved protein [Function unknown]; Region: COG3379 646529004588 Uncharacterized conserved protein [Function unknown]; Region: COG3379 646529004589 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529004590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529004591 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529004592 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 646529004593 catalytic residues [active] 646529004594 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 646529004595 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 646529004596 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 646529004597 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 646529004598 H+ Antiporter protein; Region: 2A0121; TIGR00900 646529004599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529004600 putative substrate translocation pore; other site 646529004601 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529004602 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529004603 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529004604 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 646529004605 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 646529004606 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 646529004607 B12 binding site [chemical binding]; other site 646529004608 cobalt ligand [ion binding]; other site 646529004609 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 646529004610 Ligand Binding Site [chemical binding]; other site 646529004611 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 646529004612 active site 646529004613 putative catalytic site [active] 646529004614 DNA binding site [nucleotide binding] 646529004615 putative phosphate binding site [ion binding]; other site 646529004616 metal binding site A [ion binding]; metal-binding site 646529004617 AP binding site [nucleotide binding]; other site 646529004618 metal binding site B [ion binding]; metal-binding site 646529004619 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 646529004620 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 646529004621 DNA methylase; Region: N6_N4_Mtase; pfam01555 646529004622 DNA methylase; Region: N6_N4_Mtase; cl17433 646529004623 Restriction endonuclease [Defense mechanisms]; Region: COG3587 646529004624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 646529004625 ATP binding site [chemical binding]; other site 646529004626 putative Mg++ binding site [ion binding]; other site 646529004627 Predicted amidohydrolase [General function prediction only]; Region: COG0388 646529004628 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 646529004629 putative active site [active] 646529004630 catalytic triad [active] 646529004631 dimer interface [polypeptide binding]; other site 646529004632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529004633 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529004634 putative substrate translocation pore; other site 646529004635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529004636 DGC domain; Region: DGC; pfam08859 646529004637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 646529004638 putative DNA binding site [nucleotide binding]; other site 646529004639 dimerization interface [polypeptide binding]; other site 646529004640 putative Zn2+ binding site [ion binding]; other site 646529004641 DGC domain; Region: DGC; cl01742 646529004642 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 646529004643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529004644 putative substrate translocation pore; other site 646529004645 Predicted permeases [General function prediction only]; Region: COG0701 646529004646 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 646529004647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 646529004648 dimerization interface [polypeptide binding]; other site 646529004649 putative DNA binding site [nucleotide binding]; other site 646529004650 putative Zn2+ binding site [ion binding]; other site 646529004651 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 646529004652 putative DNA binding site [nucleotide binding]; other site 646529004653 dimerization interface [polypeptide binding]; other site 646529004654 putative Zn2+ binding site [ion binding]; other site 646529004655 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 646529004656 arsenical-resistance protein; Region: acr3; TIGR00832 646529004657 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 646529004658 Low molecular weight phosphatase family; Region: LMWPc; cl00105 646529004659 active site 646529004660 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 646529004661 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529004662 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529004663 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529004664 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 646529004665 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529004666 Integral membrane protein DUF92; Region: DUF92; pfam01940 646529004667 EDD domain protein, DegV family; Region: DegV; TIGR00762 646529004668 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 646529004669 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 646529004670 MarR family; Region: MarR_2; cl17246 646529004671 GH3 auxin-responsive promoter; Region: GH3; pfam03321 646529004672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529004673 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529004674 putative substrate translocation pore; other site 646529004675 DGC domain; Region: DGC; cl01742 646529004676 TIGR04076 family protein; Region: TIGR04076 646529004677 Probable zinc-binding domain; Region: zf-trcl; pfam13451 646529004678 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 646529004679 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 646529004680 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 646529004681 DNA binding residues [nucleotide binding] 646529004682 dimer interface [polypeptide binding]; other site 646529004683 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 646529004684 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 646529004685 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 646529004686 4Fe-4S binding domain; Region: Fer4; pfam00037 646529004687 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 646529004688 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 646529004689 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 646529004690 4Fe-4S binding domain; Region: Fer4; cl02805 646529004691 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529004692 Cysteine-rich domain; Region: CCG; pfam02754 646529004693 Cysteine-rich domain; Region: CCG; pfam02754 646529004694 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 646529004695 Ligand Binding Site [chemical binding]; other site 646529004696 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529004697 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529004698 metal binding site [ion binding]; metal-binding site 646529004699 active site 646529004700 I-site; other site 646529004701 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 646529004702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 646529004703 S-adenosylmethionine binding site [chemical binding]; other site 646529004704 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529004705 dimer interface [polypeptide binding]; other site 646529004706 putative CheW interface [polypeptide binding]; other site 646529004707 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 646529004708 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 646529004709 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 646529004710 acyl-activating enzyme (AAE) consensus motif; other site 646529004711 putative AMP binding site [chemical binding]; other site 646529004712 putative active site [active] 646529004713 putative CoA binding site [chemical binding]; other site 646529004714 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 646529004715 active site 646529004716 substrate binding pocket [chemical binding]; other site 646529004717 homodimer interaction site [polypeptide binding]; other site 646529004718 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 646529004719 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 646529004720 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 646529004721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529004722 Coenzyme A binding pocket [chemical binding]; other site 646529004723 TfoX N-terminal domain; Region: TfoX_N; pfam04993 646529004724 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 646529004725 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 646529004726 transmembrane helices; other site 646529004727 Predicted membrane protein [General function prediction only]; Region: COG4194 646529004728 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 646529004729 UbiA prenyltransferase family; Region: UbiA; pfam01040 646529004730 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 646529004731 PAS fold; Region: PAS; pfam00989 646529004732 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 646529004733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529004734 Walker A motif; other site 646529004735 ATP binding site [chemical binding]; other site 646529004736 Walker B motif; other site 646529004737 arginine finger; other site 646529004738 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 646529004739 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 646529004740 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 646529004741 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 646529004742 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 646529004743 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 646529004744 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529004745 non-specific DNA binding site [nucleotide binding]; other site 646529004746 salt bridge; other site 646529004747 sequence-specific DNA binding site [nucleotide binding]; other site 646529004748 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 646529004749 Nitrogen regulatory protein P-II; Region: P-II; smart00938 646529004750 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 646529004751 EamA-like transporter family; Region: EamA; pfam00892 646529004752 EamA-like transporter family; Region: EamA; pfam00892 646529004753 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 646529004754 putative FMN binding site [chemical binding]; other site 646529004755 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 646529004756 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 646529004757 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 646529004758 Response regulator receiver domain; Region: Response_reg; pfam00072 646529004759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529004760 active site 646529004761 phosphorylation site [posttranslational modification] 646529004762 intermolecular recognition site; other site 646529004763 dimerization interface [polypeptide binding]; other site 646529004764 PAS domain S-box; Region: sensory_box; TIGR00229 646529004765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529004766 putative active site [active] 646529004767 heme pocket [chemical binding]; other site 646529004768 PAS domain S-box; Region: sensory_box; TIGR00229 646529004769 PAS domain; Region: PAS; smart00091 646529004770 putative active site [active] 646529004771 heme pocket [chemical binding]; other site 646529004772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529004773 dimer interface [polypeptide binding]; other site 646529004774 phosphorylation site [posttranslational modification] 646529004775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529004776 ATP binding site [chemical binding]; other site 646529004777 Mg2+ binding site [ion binding]; other site 646529004778 G-X-G motif; other site 646529004779 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 646529004780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529004781 active site 646529004782 phosphorylation site [posttranslational modification] 646529004783 intermolecular recognition site; other site 646529004784 dimerization interface [polypeptide binding]; other site 646529004785 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 646529004786 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 646529004787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529004788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529004789 dimer interface [polypeptide binding]; other site 646529004790 phosphorylation site [posttranslational modification] 646529004791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529004792 ATP binding site [chemical binding]; other site 646529004793 Mg2+ binding site [ion binding]; other site 646529004794 G-X-G motif; other site 646529004795 Response regulator receiver domain; Region: Response_reg; pfam00072 646529004796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529004797 active site 646529004798 phosphorylation site [posttranslational modification] 646529004799 intermolecular recognition site; other site 646529004800 dimerization interface [polypeptide binding]; other site 646529004801 Hpt domain; Region: Hpt; pfam01627 646529004802 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 646529004803 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 646529004804 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529004805 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529004806 metal binding site [ion binding]; metal-binding site 646529004807 active site 646529004808 I-site; other site 646529004809 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 646529004810 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 646529004811 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529004812 dimerization interface [polypeptide binding]; other site 646529004813 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529004814 dimer interface [polypeptide binding]; other site 646529004815 putative CheW interface [polypeptide binding]; other site 646529004816 Protein of unknown function (DUF458); Region: DUF458; pfam04308 646529004817 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 646529004818 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 646529004819 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 646529004820 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529004821 Walker A/P-loop; other site 646529004822 ATP binding site [chemical binding]; other site 646529004823 Q-loop/lid; other site 646529004824 ABC transporter signature motif; other site 646529004825 Walker B; other site 646529004826 D-loop; other site 646529004827 H-loop/switch region; other site 646529004828 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 646529004829 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 646529004830 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 646529004831 Walker A/P-loop; other site 646529004832 ATP binding site [chemical binding]; other site 646529004833 Q-loop/lid; other site 646529004834 ABC transporter signature motif; other site 646529004835 Walker B; other site 646529004836 D-loop; other site 646529004837 H-loop/switch region; other site 646529004838 EamA-like transporter family; Region: EamA; pfam00892 646529004839 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 646529004840 EamA-like transporter family; Region: EamA; pfam00892 646529004841 GEMM cis-regulatory element 646529004842 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 646529004843 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529004844 putative CheW interface [polypeptide binding]; other site 646529004845 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 646529004846 Zn binding site [ion binding]; other site 646529004847 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 646529004848 active site 1 [active] 646529004849 dimer interface [polypeptide binding]; other site 646529004850 hexamer interface [polypeptide binding]; other site 646529004851 active site 2 [active] 646529004852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529004853 dimer interface [polypeptide binding]; other site 646529004854 phosphorylation site [posttranslational modification] 646529004855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529004856 ATP binding site [chemical binding]; other site 646529004857 Mg2+ binding site [ion binding]; other site 646529004858 G-X-G motif; other site 646529004859 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 646529004860 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 646529004861 G5 domain; Region: G5; pfam07501 646529004862 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 646529004863 NlpC/P60 family; Region: NLPC_P60; pfam00877 646529004864 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 646529004865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529004866 active site 646529004867 phosphorylation site [posttranslational modification] 646529004868 intermolecular recognition site; other site 646529004869 dimerization interface [polypeptide binding]; other site 646529004870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529004871 Walker A motif; other site 646529004872 ATP binding site [chemical binding]; other site 646529004873 Walker B motif; other site 646529004874 arginine finger; other site 646529004875 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529004876 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529004877 HAMP domain; Region: HAMP; pfam00672 646529004878 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529004879 dimer interface [polypeptide binding]; other site 646529004880 phosphorylation site [posttranslational modification] 646529004881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529004882 ATP binding site [chemical binding]; other site 646529004883 Mg2+ binding site [ion binding]; other site 646529004884 G-X-G motif; other site 646529004885 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 646529004886 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 646529004887 NlpC/P60 family; Region: NLPC_P60; pfam00877 646529004888 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 646529004889 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 646529004890 putative dimer interface [polypeptide binding]; other site 646529004891 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 646529004892 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 646529004893 putative acyl-acceptor binding pocket; other site 646529004894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529004895 PAS domain; Region: PAS_9; pfam13426 646529004896 putative active site [active] 646529004897 heme pocket [chemical binding]; other site 646529004898 PAS domain S-box; Region: sensory_box; TIGR00229 646529004899 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529004900 putative active site [active] 646529004901 heme pocket [chemical binding]; other site 646529004902 PAS domain S-box; Region: sensory_box; TIGR00229 646529004903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529004904 putative active site [active] 646529004905 heme pocket [chemical binding]; other site 646529004906 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529004907 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529004908 metal binding site [ion binding]; metal-binding site 646529004909 active site 646529004910 I-site; other site 646529004911 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 646529004912 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529004913 Zn2+ binding site [ion binding]; other site 646529004914 Mg2+ binding site [ion binding]; other site 646529004915 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 646529004916 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 646529004917 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 646529004918 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 646529004919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 646529004920 motif II; other site 646529004921 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 646529004922 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 646529004923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529004924 DNA-binding site [nucleotide binding]; DNA binding site 646529004925 UTRA domain; Region: UTRA; pfam07702 646529004926 phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293 646529004927 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 646529004928 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 646529004929 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 646529004930 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 646529004931 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 646529004932 Walker A/P-loop; other site 646529004933 ATP binding site [chemical binding]; other site 646529004934 Q-loop/lid; other site 646529004935 ABC transporter signature motif; other site 646529004936 Walker B; other site 646529004937 D-loop; other site 646529004938 H-loop/switch region; other site 646529004939 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 646529004940 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 646529004941 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 646529004942 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 646529004943 active site 646529004944 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 646529004945 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 646529004946 trimer interface [polypeptide binding]; other site 646529004947 active site 646529004948 substrate binding site [chemical binding]; other site 646529004949 CoA binding site [chemical binding]; other site 646529004950 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 646529004951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529004952 Walker A/P-loop; other site 646529004953 ATP binding site [chemical binding]; other site 646529004954 Q-loop/lid; other site 646529004955 ABC transporter signature motif; other site 646529004956 Walker B; other site 646529004957 D-loop; other site 646529004958 H-loop/switch region; other site 646529004959 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 646529004960 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 646529004961 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 646529004962 Walker A/P-loop; other site 646529004963 ATP binding site [chemical binding]; other site 646529004964 Q-loop/lid; other site 646529004965 ABC transporter signature motif; other site 646529004966 Walker B; other site 646529004967 D-loop; other site 646529004968 H-loop/switch region; other site 646529004969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529004970 dimer interface [polypeptide binding]; other site 646529004971 conserved gate region; other site 646529004972 ABC-ATPase subunit interface; other site 646529004973 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 646529004974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529004975 dimer interface [polypeptide binding]; other site 646529004976 conserved gate region; other site 646529004977 ABC-ATPase subunit interface; other site 646529004978 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 646529004979 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 646529004980 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 646529004981 active site 646529004982 putative acetyltransferase; Provisional; Region: PRK03624 646529004983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529004984 Coenzyme A binding pocket [chemical binding]; other site 646529004985 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 646529004986 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 646529004987 active site 646529004988 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 646529004989 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529004990 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529004991 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529004992 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 646529004993 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 646529004994 GIY-YIG motif/motif A; other site 646529004995 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 646529004996 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 646529004997 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 646529004998 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 646529004999 active site 646529005000 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 646529005001 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 646529005002 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 646529005003 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 646529005004 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 646529005005 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 646529005006 active site 646529005007 NTP binding site [chemical binding]; other site 646529005008 metal binding triad [ion binding]; metal-binding site 646529005009 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 646529005010 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 646529005011 Rubredoxin; Region: Rubredoxin; pfam00301 646529005012 iron binding site [ion binding]; other site 646529005013 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 646529005014 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 646529005015 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 646529005016 putative [4Fe-4S] binding site [ion binding]; other site 646529005017 putative molybdopterin cofactor binding site [chemical binding]; other site 646529005018 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 646529005019 molybdopterin cofactor binding site; other site 646529005020 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 646529005021 Rubredoxin; Region: Rubredoxin; pfam00301 646529005022 iron binding site [ion binding]; other site 646529005023 Rubrerythrin [Energy production and conversion]; Region: COG1592 646529005024 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 646529005025 diiron binding motif [ion binding]; other site 646529005026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529005027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529005028 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 646529005029 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 646529005030 putative NAD(P) binding site [chemical binding]; other site 646529005031 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 646529005032 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 646529005033 hypothetical protein; Validated; Region: PRK07682 646529005034 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 646529005035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529005036 homodimer interface [polypeptide binding]; other site 646529005037 catalytic residue [active] 646529005038 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 646529005039 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 646529005040 AsnC family; Region: AsnC_trans_reg; pfam01037 646529005041 aconitate hydratase; Validated; Region: PRK07229 646529005042 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 646529005043 substrate binding site [chemical binding]; other site 646529005044 ligand binding site [chemical binding]; other site 646529005045 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 646529005046 substrate binding site [chemical binding]; other site 646529005047 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 646529005048 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 646529005049 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 646529005050 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 646529005051 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 646529005052 Mg++ binding site [ion binding]; other site 646529005053 putative catalytic motif [active] 646529005054 substrate binding site [chemical binding]; other site 646529005055 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 646529005056 active site 646529005057 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 646529005058 metal-dependent hydrolase; Provisional; Region: PRK00685 646529005059 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 646529005060 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 646529005061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529005062 DNA-binding site [nucleotide binding]; DNA binding site 646529005063 DRTGG domain; Region: DRTGG; pfam07085 646529005064 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 646529005065 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 646529005066 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 646529005067 active site 646529005068 PHP Thumb interface [polypeptide binding]; other site 646529005069 metal binding site [ion binding]; metal-binding site 646529005070 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 646529005071 generic binding surface II; other site 646529005072 generic binding surface I; other site 646529005073 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 646529005074 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 646529005075 active site 646529005076 (T/H)XGH motif; other site 646529005077 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 646529005078 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 646529005079 RNA polymerase subunit 9; Region: RPOL9; smart00661 646529005080 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 646529005081 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 646529005082 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 646529005083 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529005084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529005085 active site 646529005086 phosphorylation site [posttranslational modification] 646529005087 intermolecular recognition site; other site 646529005088 dimerization interface [polypeptide binding]; other site 646529005089 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529005090 DNA binding site [nucleotide binding] 646529005091 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529005092 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529005093 dimerization interface [polypeptide binding]; other site 646529005094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529005095 dimer interface [polypeptide binding]; other site 646529005096 phosphorylation site [posttranslational modification] 646529005097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529005098 ATP binding site [chemical binding]; other site 646529005099 Mg2+ binding site [ion binding]; other site 646529005100 G-X-G motif; other site 646529005101 DNA polymerase I; Provisional; Region: PRK05755 646529005102 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 646529005103 active site 646529005104 metal binding site 1 [ion binding]; metal-binding site 646529005105 putative 5' ssDNA interaction site; other site 646529005106 metal binding site 3; metal-binding site 646529005107 metal binding site 2 [ion binding]; metal-binding site 646529005108 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 646529005109 putative DNA binding site [nucleotide binding]; other site 646529005110 putative metal binding site [ion binding]; other site 646529005111 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 646529005112 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 646529005113 active site 646529005114 DNA binding site [nucleotide binding] 646529005115 catalytic site [active] 646529005116 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 646529005117 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 646529005118 DNA binding site [nucleotide binding] 646529005119 catalytic residue [active] 646529005120 H2TH interface [polypeptide binding]; other site 646529005121 putative catalytic residues [active] 646529005122 turnover-facilitating residue; other site 646529005123 intercalation triad [nucleotide binding]; other site 646529005124 8OG recognition residue [nucleotide binding]; other site 646529005125 putative reading head residues; other site 646529005126 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 646529005127 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 646529005128 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 646529005129 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 646529005130 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 646529005131 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 646529005132 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 646529005133 NlpC/P60 family; Region: NLPC_P60; pfam00877 646529005134 EamA-like transporter family; Region: EamA; pfam00892 646529005135 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 646529005136 EamA-like transporter family; Region: EamA; pfam00892 646529005137 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 646529005138 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 646529005139 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 646529005140 Catalytic site [active] 646529005141 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 646529005142 putative active site [active] 646529005143 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 646529005144 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 646529005145 motif II; other site 646529005146 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 646529005147 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 646529005148 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 646529005149 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 646529005150 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 646529005151 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 646529005152 Ligand binding site; other site 646529005153 Putative Catalytic site; other site 646529005154 DXD motif; other site 646529005155 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 646529005156 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 646529005157 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 646529005158 RNA binding surface [nucleotide binding]; other site 646529005159 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 646529005160 active site 646529005161 L-lactate permease; Region: Lactate_perm; cl00701 646529005162 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 646529005163 FAD binding domain; Region: FAD_binding_4; pfam01565 646529005164 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 646529005165 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 646529005166 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529005167 Cysteine-rich domain; Region: CCG; pfam02754 646529005168 Cysteine-rich domain; Region: CCG; pfam02754 646529005169 Transcriptional regulators [Transcription]; Region: FadR; COG2186 646529005170 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529005171 DNA-binding site [nucleotide binding]; DNA binding site 646529005172 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 646529005173 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529005174 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529005175 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 646529005176 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 646529005177 active site 646529005178 CobD/Cbib protein; Region: CobD_Cbib; cl00561 646529005179 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 646529005180 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 646529005181 RNA binding site [nucleotide binding]; other site 646529005182 hexamer interface [polypeptide binding]; other site 646529005183 Histidine-zinc binding site [chemical binding]; other site 646529005184 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 646529005185 homotrimer interaction site [polypeptide binding]; other site 646529005186 active site 646529005187 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 646529005188 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 646529005189 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 646529005190 prephenate dehydrogenase; Validated; Region: PRK08507 646529005191 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 646529005192 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 646529005193 hinge; other site 646529005194 active site 646529005195 AzlC protein; Region: AzlC; pfam03591 646529005196 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 646529005197 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 646529005198 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 646529005199 CoenzymeA binding site [chemical binding]; other site 646529005200 subunit interaction site [polypeptide binding]; other site 646529005201 PHB binding site; other site 646529005202 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 646529005203 Eukaryotic phosphomannomutase; Region: PMM; cl17107 646529005204 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 646529005205 motif II; other site 646529005206 CAAX protease self-immunity; Region: Abi; pfam02517 646529005207 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 646529005208 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 646529005209 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 646529005210 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 646529005211 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 646529005212 cytidylate kinase; Provisional; Region: cmk; PRK00023 646529005213 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 646529005214 CMP-binding site; other site 646529005215 The sites determining sugar specificity; other site 646529005216 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 646529005217 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 646529005218 putative acyl-acceptor binding pocket; other site 646529005219 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 646529005220 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 646529005221 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 646529005222 RNA binding site [nucleotide binding]; other site 646529005223 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 646529005224 RNA binding site [nucleotide binding]; other site 646529005225 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 646529005226 RNA binding site [nucleotide binding]; other site 646529005227 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 646529005228 RNA binding site [nucleotide binding]; other site 646529005229 cell division protein FtsW; Region: ftsW; TIGR02614 646529005230 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 646529005231 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 646529005232 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 646529005233 Protein of unknown function (DUF512); Region: DUF512; pfam04459 646529005234 GTP-binding protein Der; Reviewed; Region: PRK00093 646529005235 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 646529005236 G1 box; other site 646529005237 GTP/Mg2+ binding site [chemical binding]; other site 646529005238 Switch I region; other site 646529005239 G2 box; other site 646529005240 Switch II region; other site 646529005241 G3 box; other site 646529005242 G4 box; other site 646529005243 G5 box; other site 646529005244 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 646529005245 G1 box; other site 646529005246 GTP/Mg2+ binding site [chemical binding]; other site 646529005247 Switch I region; other site 646529005248 G2 box; other site 646529005249 G3 box; other site 646529005250 Switch II region; other site 646529005251 G4 box; other site 646529005252 G5 box; other site 646529005253 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 646529005254 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 646529005255 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 646529005256 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 646529005257 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 646529005258 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 646529005259 G1 box; other site 646529005260 GTP/Mg2+ binding site [chemical binding]; other site 646529005261 G2 box; other site 646529005262 Switch I region; other site 646529005263 G3 box; other site 646529005264 Switch II region; other site 646529005265 G4 box; other site 646529005266 G5 box; other site 646529005267 enoyl-CoA hydratase; Provisional; Region: PRK09245 646529005268 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 646529005269 substrate binding site [chemical binding]; other site 646529005270 oxyanion hole (OAH) forming residues; other site 646529005271 trimer interface [polypeptide binding]; other site 646529005272 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 646529005273 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 646529005274 active site 646529005275 FOG: CBS domain [General function prediction only]; Region: COG0517 646529005276 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 646529005277 PAS domain; Region: PAS; smart00091 646529005278 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529005279 putative active site [active] 646529005280 heme pocket [chemical binding]; other site 646529005281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529005282 putative active site [active] 646529005283 heme pocket [chemical binding]; other site 646529005284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529005285 Walker A motif; other site 646529005286 ATP binding site [chemical binding]; other site 646529005287 Walker B motif; other site 646529005288 arginine finger; other site 646529005289 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 646529005290 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 646529005291 CoA binding domain; Region: CoA_binding_2; pfam13380 646529005292 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 646529005293 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 646529005294 hypothetical protein; Provisional; Region: PRK04435 646529005295 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 646529005296 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 646529005297 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 646529005298 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 646529005299 ATP binding site [chemical binding]; other site 646529005300 putative Mg++ binding site [ion binding]; other site 646529005301 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529005302 nucleotide binding region [chemical binding]; other site 646529005303 ATP-binding site [chemical binding]; other site 646529005304 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 646529005305 PLD-like domain; Region: PLDc_2; pfam13091 646529005306 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 646529005307 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 646529005308 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 646529005309 SWIM zinc finger; Region: SWIM; pfam04434 646529005310 hydrolase, hydrolyzing O-glycosyl compounds; Region: PLN02763 646529005311 Catalytic domain of Protein Kinases; Region: PKc; cd00180 646529005312 active site 646529005313 ATP binding site [chemical binding]; other site 646529005314 substrate binding site [chemical binding]; other site 646529005315 activation loop (A-loop); other site 646529005316 FemAB family; Region: FemAB; pfam02388 646529005317 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 646529005318 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 646529005319 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 646529005320 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 646529005321 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 646529005322 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 646529005323 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 646529005324 acyl-activating enzyme (AAE) consensus motif; other site 646529005325 putative AMP binding site [chemical binding]; other site 646529005326 putative active site [active] 646529005327 putative CoA binding site [chemical binding]; other site 646529005328 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 646529005329 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 646529005330 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 646529005331 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 646529005332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529005333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529005334 WHG domain; Region: WHG; pfam13305 646529005335 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 646529005336 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 646529005337 active site 2 [active] 646529005338 active site 1 [active] 646529005339 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 646529005340 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 646529005341 B12 binding site [chemical binding]; other site 646529005342 cobalt ligand [ion binding]; other site 646529005343 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 646529005344 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 646529005345 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 646529005346 NAD(P) binding site [chemical binding]; other site 646529005347 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 646529005348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529005349 FeS/SAM binding site; other site 646529005350 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 646529005351 PAS fold; Region: PAS_4; pfam08448 646529005352 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529005353 putative active site [active] 646529005354 heme pocket [chemical binding]; other site 646529005355 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 646529005356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529005357 Walker A motif; other site 646529005358 ATP binding site [chemical binding]; other site 646529005359 Walker B motif; other site 646529005360 arginine finger; other site 646529005361 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529005362 PAS fold; Region: PAS_4; pfam08448 646529005363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529005364 putative active site [active] 646529005365 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 646529005366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529005367 Walker A motif; other site 646529005368 ATP binding site [chemical binding]; other site 646529005369 Walker B motif; other site 646529005370 arginine finger; other site 646529005371 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529005372 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 646529005373 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 646529005374 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 646529005375 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 646529005376 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 646529005377 catalytic residue [active] 646529005378 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 646529005379 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 646529005380 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 646529005381 B12 binding site [chemical binding]; other site 646529005382 cobalt ligand [ion binding]; other site 646529005383 MutL protein; Region: MutL; pfam13941 646529005384 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 646529005385 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 646529005386 active site 646529005387 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 646529005388 dimer interface [polypeptide binding]; other site 646529005389 substrate binding site [chemical binding]; other site 646529005390 catalytic residue [active] 646529005391 Arginase family; Region: Arginase; cd09989 646529005392 agmatinase; Region: agmatinase; TIGR01230 646529005393 active site 646529005394 Mn binding site [ion binding]; other site 646529005395 oligomer interface [polypeptide binding]; other site 646529005396 amino acid transporter; Region: 2A0306; TIGR00909 646529005397 quinolinate synthetase; Provisional; Region: PRK09375 646529005398 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 646529005399 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 646529005400 dimerization interface [polypeptide binding]; other site 646529005401 active site 646529005402 L-aspartate oxidase; Provisional; Region: PRK06175 646529005403 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 646529005404 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 646529005405 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 646529005406 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 646529005407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529005408 Walker A/P-loop; other site 646529005409 ATP binding site [chemical binding]; other site 646529005410 Q-loop/lid; other site 646529005411 ABC transporter signature motif; other site 646529005412 Walker B; other site 646529005413 D-loop; other site 646529005414 H-loop/switch region; other site 646529005415 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 646529005416 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 646529005417 Uncharacterized conserved protein [Function unknown]; Region: COG1633 646529005418 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 646529005419 diiron binding motif [ion binding]; other site 646529005420 Propionate catabolism activator; Region: PrpR_N; pfam06506 646529005421 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529005422 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529005423 putative active site [active] 646529005424 heme pocket [chemical binding]; other site 646529005425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529005426 Walker A motif; other site 646529005427 ATP binding site [chemical binding]; other site 646529005428 Walker B motif; other site 646529005429 arginine finger; other site 646529005430 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529005431 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 646529005432 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 646529005433 CoA-ligase; Region: Ligase_CoA; pfam00549 646529005434 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 646529005435 CoA binding domain; Region: CoA_binding; smart00881 646529005436 CoA-ligase; Region: Ligase_CoA; pfam00549 646529005437 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 646529005438 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 646529005439 B12 binding site [chemical binding]; other site 646529005440 cobalt ligand [ion binding]; other site 646529005441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 646529005442 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 646529005443 dimer interface [polypeptide binding]; other site 646529005444 substrate binding site [chemical binding]; other site 646529005445 metal binding site [ion binding]; metal-binding site 646529005446 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 646529005447 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 646529005448 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 646529005449 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 646529005450 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 646529005451 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 646529005452 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 646529005453 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 646529005454 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 646529005455 carboxyltransferase (CT) interaction site; other site 646529005456 biotinylation site [posttranslational modification]; other site 646529005457 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; pfam01184 646529005458 acetyl-CoA synthetase; Provisional; Region: PRK00174 646529005459 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 646529005460 active site 646529005461 CoA binding site [chemical binding]; other site 646529005462 acyl-activating enzyme (AAE) consensus motif; other site 646529005463 AMP binding site [chemical binding]; other site 646529005464 acetate binding site [chemical binding]; other site 646529005465 Transcriptional regulator [Transcription]; Region: LysR; COG0583 646529005466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 646529005467 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 646529005468 putative dimerization interface [polypeptide binding]; other site 646529005469 Predicted membrane protein [Function unknown]; Region: COG2855 646529005470 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 646529005471 dihydrodipicolinate synthase; Region: dapA; TIGR00674 646529005472 dimer interface [polypeptide binding]; other site 646529005473 active site 646529005474 catalytic residue [active] 646529005475 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 646529005476 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 646529005477 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 646529005478 active site 646529005479 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 646529005480 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529005481 FeS/SAM binding site; other site 646529005482 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 646529005483 hydroxyglutarate oxidase; Provisional; Region: PRK11728 646529005484 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 646529005485 dinuclear metal binding motif [ion binding]; other site 646529005486 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 646529005487 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 646529005488 active site 646529005489 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 646529005490 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 646529005491 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 646529005492 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 646529005493 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 646529005494 putative metal binding site [ion binding]; other site 646529005495 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 646529005496 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 646529005497 putative metal binding site [ion binding]; other site 646529005498 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 646529005499 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 646529005500 putative metal binding site [ion binding]; other site 646529005501 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 646529005502 putative MPT binding site; other site 646529005503 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 646529005504 XdhC Rossmann domain; Region: XdhC_C; pfam13478 646529005505 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 646529005506 Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867 646529005507 substrate binding pocket [chemical binding]; other site 646529005508 substrate-Mg2+ binding site; other site 646529005509 aspartate-rich region 1; other site 646529005510 aspartate-rich region 2; other site 646529005511 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 646529005512 UbiA prenyltransferase family; Region: UbiA; pfam01040 646529005513 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 646529005514 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529005515 FeS/SAM binding site; other site 646529005516 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 646529005517 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529005518 FeS/SAM binding site; other site 646529005519 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 646529005520 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 646529005521 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 646529005522 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 646529005523 substrate binding pocket [chemical binding]; other site 646529005524 chain length determination region; other site 646529005525 substrate-Mg2+ binding site; other site 646529005526 catalytic residues [active] 646529005527 aspartate-rich region 1; other site 646529005528 active site lid residues [active] 646529005529 aspartate-rich region 2; other site 646529005530 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 646529005531 ResB-like family; Region: ResB; pfam05140 646529005532 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 646529005533 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 646529005534 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 646529005535 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 646529005536 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 646529005537 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 646529005538 tRNA; other site 646529005539 putative tRNA binding site [nucleotide binding]; other site 646529005540 putative NADP binding site [chemical binding]; other site 646529005541 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 646529005542 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 646529005543 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 646529005544 domain interfaces; other site 646529005545 active site 646529005546 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 646529005547 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 646529005548 active site 646529005549 SAM binding site [chemical binding]; other site 646529005550 homodimer interface [polypeptide binding]; other site 646529005551 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 646529005552 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 646529005553 active site 646529005554 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 646529005555 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529005556 FeS/SAM binding site; other site 646529005557 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 646529005558 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 646529005559 dimer interface [polypeptide binding]; other site 646529005560 active site 646529005561 Schiff base residues; other site 646529005562 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 646529005563 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 646529005564 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 646529005565 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 646529005566 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 646529005567 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 646529005568 inhibitor-cofactor binding pocket; inhibition site 646529005569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529005570 catalytic residue [active] 646529005571 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 646529005572 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 646529005573 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 646529005574 active site 646529005575 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 646529005576 Coat F domain; Region: Coat_F; pfam07875 646529005577 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 646529005578 dinuclear metal binding motif [ion binding]; other site 646529005579 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 646529005580 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 646529005581 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 646529005582 substrate binding pocket [chemical binding]; other site 646529005583 chain length determination region; other site 646529005584 substrate-Mg2+ binding site; other site 646529005585 catalytic residues [active] 646529005586 aspartate-rich region 1; other site 646529005587 active site lid residues [active] 646529005588 aspartate-rich region 2; other site 646529005589 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 646529005590 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 646529005591 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 646529005592 active site clefts [active] 646529005593 zinc binding site [ion binding]; other site 646529005594 dimer interface [polypeptide binding]; other site 646529005595 PhoH-like protein; Region: PhoH; cl17668 646529005596 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 646529005597 active site 646529005598 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 646529005599 homodimer interface [polypeptide binding]; other site 646529005600 chemical substrate binding site [chemical binding]; other site 646529005601 oligomer interface [polypeptide binding]; other site 646529005602 metal binding site [ion binding]; metal-binding site 646529005603 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 646529005604 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 646529005605 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 646529005606 Ligand Binding Site [chemical binding]; other site 646529005607 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 646529005608 GAF domain; Region: GAF_3; pfam13492 646529005609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529005610 dimer interface [polypeptide binding]; other site 646529005611 phosphorylation site [posttranslational modification] 646529005612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529005613 ATP binding site [chemical binding]; other site 646529005614 Mg2+ binding site [ion binding]; other site 646529005615 G-X-G motif; other site 646529005616 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 646529005617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529005618 active site 646529005619 phosphorylation site [posttranslational modification] 646529005620 intermolecular recognition site; other site 646529005621 dimerization interface [polypeptide binding]; other site 646529005622 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529005623 DNA binding site [nucleotide binding] 646529005624 Amino acid permease; Region: AA_permease_2; pfam13520 646529005625 K+ potassium transporter; Region: K_trans; cl15781 646529005626 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 646529005627 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 646529005628 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 646529005629 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 646529005630 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529005631 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529005632 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529005633 SdpI/YhfL protein family; Region: SdpI; pfam13630 646529005634 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 646529005635 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 646529005636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 646529005637 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 646529005638 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 646529005639 DinB superfamily; Region: DinB_2; pfam12867 646529005640 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 646529005641 CoenzymeA binding site [chemical binding]; other site 646529005642 subunit interaction site [polypeptide binding]; other site 646529005643 PHB binding site; other site 646529005644 Spore germination protein; Region: Spore_permease; cl17796 646529005645 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 646529005646 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 646529005647 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 646529005648 Int/Topo IB signature motif; other site 646529005649 Helix-turn-helix domain; Region: HTH_17; pfam12728 646529005650 SIR2-like domain; Region: SIR2_2; pfam13289 646529005651 AAA ATPase domain; Region: AAA_16; pfam13191 646529005652 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 646529005653 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 646529005654 AAA domain; Region: AAA_12; pfam13087 646529005655 multiple promoter invertase; Provisional; Region: mpi; PRK13413 646529005656 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 646529005657 catalytic residues [active] 646529005658 catalytic nucleophile [active] 646529005659 Presynaptic Site I dimer interface [polypeptide binding]; other site 646529005660 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 646529005661 Synaptic Flat tetramer interface [polypeptide binding]; other site 646529005662 Synaptic Site I dimer interface [polypeptide binding]; other site 646529005663 DNA binding site [nucleotide binding] 646529005664 Domain of unknown function (DUF927); Region: DUF927; cl12098 646529005665 HNH endonuclease; Region: HNH_5; pfam14279 646529005666 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 646529005667 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 646529005668 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 646529005669 active site 646529005670 dimerization interface [polypeptide binding]; other site 646529005671 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 646529005672 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 646529005673 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 646529005674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 646529005675 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 646529005676 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 646529005677 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 646529005678 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529005679 non-specific DNA binding site [nucleotide binding]; other site 646529005680 salt bridge; other site 646529005681 sequence-specific DNA binding site [nucleotide binding]; other site 646529005682 Helix-turn-helix domain; Region: HTH_17; pfam12728 646529005683 Helix-turn-helix domain; Region: HTH_17; cl17695 646529005684 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 646529005685 hypothetical protein; Provisional; Region: PRK00106 646529005686 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 646529005687 salt bridge; other site 646529005688 non-specific DNA binding site [nucleotide binding]; other site 646529005689 sequence-specific DNA binding site [nucleotide binding]; other site 646529005690 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 646529005691 ATP binding site [chemical binding]; other site 646529005692 putative Mg++ binding site [ion binding]; other site 646529005693 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529005694 nucleotide binding region [chemical binding]; other site 646529005695 ATP-binding site [chemical binding]; other site 646529005696 large terminase protein; Provisional; Region: 17; PHA02533 646529005697 Terminase-like family; Region: Terminase_6; pfam03237 646529005698 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 646529005699 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 646529005700 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 646529005701 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529005702 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529005703 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529005704 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 646529005705 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 646529005706 active site 646529005707 DNA binding site [nucleotide binding] 646529005708 Int/Topo IB signature motif; other site 646529005709 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 646529005710 EamA-like transporter family; Region: EamA; pfam00892 646529005711 EamA-like transporter family; Region: EamA; pfam00892 646529005712 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 646529005713 Flavoprotein; Region: Flavoprotein; pfam02441 646529005714 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 646529005715 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529005716 PAS domain; Region: PAS; smart00091 646529005717 putative active site [active] 646529005718 heme pocket [chemical binding]; other site 646529005719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529005720 Walker A motif; other site 646529005721 ATP binding site [chemical binding]; other site 646529005722 Walker B motif; other site 646529005723 arginine finger; other site 646529005724 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529005725 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 646529005726 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 646529005727 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 646529005728 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 646529005729 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 646529005730 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 646529005731 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 646529005732 catalytic loop [active] 646529005733 iron binding site [ion binding]; other site 646529005734 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 646529005735 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 646529005736 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 646529005737 xanthine permease; Region: pbuX; TIGR03173 646529005738 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 646529005739 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 646529005740 phosphate binding site [ion binding]; other site 646529005741 4Fe-4S binding domain; Region: Fer4; cl02805 646529005742 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 646529005743 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 646529005744 active site 646529005745 putative substrate binding pocket [chemical binding]; other site 646529005746 threonine synthase; Validated; Region: PRK06260 646529005747 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 646529005748 homodimer interface [polypeptide binding]; other site 646529005749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529005750 catalytic residue [active] 646529005751 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 646529005752 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 646529005753 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 646529005754 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 646529005755 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 646529005756 catalytic residue [active] 646529005757 GAF domain; Region: GAF; cl17456 646529005758 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529005759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529005760 Walker A motif; other site 646529005761 ATP binding site [chemical binding]; other site 646529005762 Walker B motif; other site 646529005763 arginine finger; other site 646529005764 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529005765 peptidase; Reviewed; Region: PRK13004 646529005766 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 646529005767 putative metal binding site [ion binding]; other site 646529005768 putative dimer interface [polypeptide binding]; other site 646529005769 probable carbamoyltransferase YgeW; Region: ygeW; TIGR03316 646529005770 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 646529005771 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 646529005772 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 646529005773 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 646529005774 putative substrate binding site [chemical binding]; other site 646529005775 nucleotide binding site [chemical binding]; other site 646529005776 nucleotide binding site [chemical binding]; other site 646529005777 homodimer interface [polypeptide binding]; other site 646529005778 phenylhydantoinase; Validated; Region: PRK08323 646529005779 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 646529005780 tetramer interface [polypeptide binding]; other site 646529005781 active site 646529005782 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 646529005783 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 646529005784 catalytic loop [active] 646529005785 iron binding site [ion binding]; other site 646529005786 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 646529005787 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 646529005788 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 646529005789 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 646529005790 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 646529005791 active site 646529005792 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 646529005793 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 646529005794 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 646529005795 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 646529005796 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 646529005797 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 646529005798 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 646529005799 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 646529005800 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 646529005801 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 646529005802 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 646529005803 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 646529005804 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 646529005805 active site 646529005806 putative substrate binding pocket [chemical binding]; other site 646529005807 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 646529005808 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 646529005809 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 646529005810 active site 646529005811 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 646529005812 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 646529005813 Na2 binding site [ion binding]; other site 646529005814 putative substrate binding site 1 [chemical binding]; other site 646529005815 Na binding site 1 [ion binding]; other site 646529005816 putative substrate binding site 2 [chemical binding]; other site 646529005817 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 646529005818 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529005819 Zn2+ binding site [ion binding]; other site 646529005820 Mg2+ binding site [ion binding]; other site 646529005821 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 646529005822 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 646529005823 catalytic residues [active] 646529005824 catalytic nucleophile [active] 646529005825 Recombinase; Region: Recombinase; pfam07508 646529005826 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 646529005827 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 646529005828 active site 646529005829 SUMO-1 interface [polypeptide binding]; other site 646529005830 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 646529005831 Ycf48-like protein; Provisional; Region: PRK13684 646529005832 BNR repeat-like domain; Region: BNR_2; pfam13088 646529005833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529005834 Coenzyme A binding pocket [chemical binding]; other site 646529005835 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 646529005836 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 646529005837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529005838 Coenzyme A binding pocket [chemical binding]; other site 646529005839 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 646529005840 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 646529005841 putative NAD(P) binding site [chemical binding]; other site 646529005842 putative active site [active] 646529005843 LysE type translocator; Region: LysE; cl00565 646529005844 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 646529005845 Methyltransferase domain; Region: Methyltransf_31; pfam13847 646529005846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529005847 S-adenosylmethionine binding site [chemical binding]; other site 646529005848 putative acetyltransferase; Provisional; Region: PRK03624 646529005849 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529005850 Coenzyme A binding pocket [chemical binding]; other site 646529005851 SurA N-terminal domain; Region: SurA_N_3; cl07813 646529005852 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 646529005853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529005854 Coenzyme A binding pocket [chemical binding]; other site 646529005855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529005856 Coenzyme A binding pocket [chemical binding]; other site 646529005857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529005858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529005859 hypothetical protein; Provisional; Region: PRK08296 646529005860 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 646529005861 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 646529005862 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 646529005863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529005864 Coenzyme A binding pocket [chemical binding]; other site 646529005865 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 646529005866 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 646529005867 FAD binding domain; Region: FAD_binding_4; pfam01565 646529005868 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 646529005869 Berberine and berberine like; Region: BBE; pfam08031 646529005870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 646529005871 NAD(P) binding site [chemical binding]; other site 646529005872 active site 646529005873 LysE type translocator; Region: LysE; cl00565 646529005874 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 646529005875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529005876 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 646529005877 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529005878 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 646529005879 dimer interaction site [polypeptide binding]; other site 646529005880 substrate-binding tunnel; other site 646529005881 active site 646529005882 catalytic site [active] 646529005883 substrate binding site [chemical binding]; other site 646529005884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529005885 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529005886 putative substrate translocation pore; other site 646529005887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529005888 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529005889 putative substrate translocation pore; other site 646529005890 Transcriptional regulator [Transcription]; Region: LysR; COG0583 646529005891 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 646529005892 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 646529005893 putative dimerization interface [polypeptide binding]; other site 646529005894 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 646529005895 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 646529005896 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 646529005897 Walker A/P-loop; other site 646529005898 ATP binding site [chemical binding]; other site 646529005899 Q-loop/lid; other site 646529005900 ABC transporter signature motif; other site 646529005901 Walker B; other site 646529005902 D-loop; other site 646529005903 H-loop/switch region; other site 646529005904 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 646529005905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529005906 dimer interface [polypeptide binding]; other site 646529005907 conserved gate region; other site 646529005908 putative PBP binding loops; other site 646529005909 ABC-ATPase subunit interface; other site 646529005910 NMT1-like family; Region: NMT1_2; pfam13379 646529005911 NMT1/THI5 like; Region: NMT1; pfam09084 646529005912 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 646529005913 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 646529005914 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529005915 DNA-binding site [nucleotide binding]; DNA binding site 646529005916 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 646529005917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529005918 homodimer interface [polypeptide binding]; other site 646529005919 catalytic residue [active] 646529005920 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 646529005921 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 646529005922 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529005923 dimer interface [polypeptide binding]; other site 646529005924 putative CheW interface [polypeptide binding]; other site 646529005925 ykoK leader 646529005926 MgtE intracellular N domain; Region: MgtE_N; smart00924 646529005927 FOG: CBS domain [General function prediction only]; Region: COG0517 646529005928 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 646529005929 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 646529005930 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 646529005931 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 646529005932 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 646529005933 active site 646529005934 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 646529005935 PAS domain S-box; Region: sensory_box; TIGR00229 646529005936 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529005937 putative active site [active] 646529005938 heme pocket [chemical binding]; other site 646529005939 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 646529005940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529005941 Walker A motif; other site 646529005942 ATP binding site [chemical binding]; other site 646529005943 Walker B motif; other site 646529005944 arginine finger; other site 646529005945 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529005946 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 646529005947 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 646529005948 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 646529005949 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 646529005950 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 646529005951 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529005952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529005953 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529005954 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 646529005955 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 646529005956 substrate binding site [chemical binding]; other site 646529005957 oxyanion hole (OAH) forming residues; other site 646529005958 trimer interface [polypeptide binding]; other site 646529005959 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 646529005960 carboxyltransferase (CT) interaction site; other site 646529005961 biotinylation site [posttranslational modification]; other site 646529005962 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 646529005963 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 646529005964 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 646529005965 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 646529005966 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 646529005967 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 646529005968 FAD binding site [chemical binding]; other site 646529005969 homotetramer interface [polypeptide binding]; other site 646529005970 substrate binding pocket [chemical binding]; other site 646529005971 catalytic base [active] 646529005972 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 646529005973 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 646529005974 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 646529005975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529005976 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529005977 putative substrate translocation pore; other site 646529005978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 646529005979 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 646529005980 phage shock protein A; Region: phageshock_pspA; TIGR02977 646529005981 Tim44-like domain; Region: Tim44; cl09208 646529005982 OPT oligopeptide transporter protein; Region: OPT; cl14607 646529005983 putative oligopeptide transporter, OPT family; Region: TIGR00733 646529005984 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 646529005985 dipeptidase PepV; Reviewed; Region: PRK07318 646529005986 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 646529005987 active site 646529005988 metal binding site [ion binding]; metal-binding site 646529005989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529005990 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529005991 putative substrate translocation pore; other site 646529005992 Predicted transcriptional regulators [Transcription]; Region: COG1695 646529005993 Transcriptional regulator PadR-like family; Region: PadR; cl17335 646529005994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529005995 non-specific DNA binding site [nucleotide binding]; other site 646529005996 salt bridge; other site 646529005997 sequence-specific DNA binding site [nucleotide binding]; other site 646529005998 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 646529005999 Esterase/lipase [General function prediction only]; Region: COG1647 646529006000 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 646529006001 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 646529006002 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 646529006003 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 646529006004 AsnC family; Region: AsnC_trans_reg; pfam01037 646529006005 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 646529006006 oligomerization interface [polypeptide binding]; other site 646529006007 active site 646529006008 metal binding site [ion binding]; metal-binding site 646529006009 pyruvate carboxylase; Reviewed; Region: PRK12999 646529006010 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 646529006011 ATP-grasp domain; Region: ATP-grasp_4; cl17255 646529006012 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 646529006013 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 646529006014 active site 646529006015 catalytic residues [active] 646529006016 metal binding site [ion binding]; metal-binding site 646529006017 homodimer binding site [polypeptide binding]; other site 646529006018 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 646529006019 carboxyltransferase (CT) interaction site; other site 646529006020 biotinylation site [posttranslational modification]; other site 646529006021 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 646529006022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529006023 non-specific DNA binding site [nucleotide binding]; other site 646529006024 salt bridge; other site 646529006025 sequence-specific DNA binding site [nucleotide binding]; other site 646529006026 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529006027 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529006028 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529006029 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 646529006030 VanW like protein; Region: VanW; pfam04294 646529006031 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 646529006032 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 646529006033 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 646529006034 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 646529006035 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 646529006036 catalytic residues [active] 646529006037 enterobactin exporter EntS; Provisional; Region: PRK10489 646529006038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529006039 putative substrate translocation pore; other site 646529006040 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 646529006041 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 646529006042 GIY-YIG motif/motif A; other site 646529006043 active site 646529006044 catalytic site [active] 646529006045 putative DNA binding site [nucleotide binding]; other site 646529006046 metal binding site [ion binding]; metal-binding site 646529006047 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 646529006048 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 646529006049 endonuclease III; Region: ENDO3c; smart00478 646529006050 minor groove reading motif; other site 646529006051 helix-hairpin-helix signature motif; other site 646529006052 substrate binding pocket [chemical binding]; other site 646529006053 active site 646529006054 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 646529006055 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 646529006056 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529006057 Coenzyme A binding pocket [chemical binding]; other site 646529006058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 646529006059 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 646529006060 Cation efflux family; Region: Cation_efflux; pfam01545 646529006061 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 646529006062 active site 646529006063 catalytic triad [active] 646529006064 oxyanion hole [active] 646529006065 Uncharacterized conserved protein [Function unknown]; Region: COG0398 646529006066 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 646529006067 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 646529006068 GAF domain; Region: GAF; pfam01590 646529006069 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529006070 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529006071 metal binding site [ion binding]; metal-binding site 646529006072 active site 646529006073 I-site; other site 646529006074 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 646529006075 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 646529006076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529006077 homodimer interface [polypeptide binding]; other site 646529006078 catalytic residue [active] 646529006079 cobalamin synthase; Reviewed; Region: cobS; PRK00235 646529006080 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 646529006081 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 646529006082 homotrimer interface [polypeptide binding]; other site 646529006083 Walker A motif; other site 646529006084 GTP binding site [chemical binding]; other site 646529006085 Walker B motif; other site 646529006086 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 646529006087 Domain of unknown function DUF21; Region: DUF21; pfam01595 646529006088 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 646529006089 Transporter associated domain; Region: CorC_HlyC; smart01091 646529006090 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 646529006091 active site 646529006092 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 646529006093 dimer interface [polypeptide binding]; other site 646529006094 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 646529006095 Ligand Binding Site [chemical binding]; other site 646529006096 Molecular Tunnel; other site 646529006097 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 646529006098 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 646529006099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529006100 homodimer interface [polypeptide binding]; other site 646529006101 catalytic residue [active] 646529006102 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 646529006103 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 646529006104 NAD(P) binding pocket [chemical binding]; other site 646529006105 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 646529006106 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 646529006107 dimer interface [polypeptide binding]; other site 646529006108 active site 646529006109 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 646529006110 catalytic residues [active] 646529006111 substrate binding site [chemical binding]; other site 646529006112 aspartate aminotransferase; Provisional; Region: PRK06836 646529006113 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 646529006114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529006115 homodimer interface [polypeptide binding]; other site 646529006116 catalytic residue [active] 646529006117 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 646529006118 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 646529006119 active site 646529006120 nucleophile elbow; other site 646529006121 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529006122 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529006123 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 646529006124 putative FMN binding site [chemical binding]; other site 646529006125 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 646529006126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529006127 dimerization interface [polypeptide binding]; other site 646529006128 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 646529006129 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529006130 dimer interface [polypeptide binding]; other site 646529006131 putative CheW interface [polypeptide binding]; other site 646529006132 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 646529006133 Protein of unknown function DUF45; Region: DUF45; pfam01863 646529006134 Transcriptional regulator [Transcription]; Region: LysR; COG0583 646529006135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 646529006136 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 646529006137 putative dimerization interface [polypeptide binding]; other site 646529006138 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 646529006139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529006140 active site 646529006141 phosphorylation site [posttranslational modification] 646529006142 intermolecular recognition site; other site 646529006143 dimerization interface [polypeptide binding]; other site 646529006144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529006145 Walker A motif; other site 646529006146 ATP binding site [chemical binding]; other site 646529006147 Walker B motif; other site 646529006148 arginine finger; other site 646529006149 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529006150 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 646529006151 NlpC/P60 family; Region: NLPC_P60; pfam00877 646529006152 Uncharacterized conserved protein [Function unknown]; Region: COG3937 646529006153 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 646529006154 ABC1 family; Region: ABC1; pfam03109 646529006155 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 646529006156 active site 646529006157 ATP binding site [chemical binding]; other site 646529006158 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 646529006159 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 646529006160 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 646529006161 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 646529006162 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 646529006163 4Fe-4S binding domain; Region: Fer4; pfam00037 646529006164 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 646529006165 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529006166 Cysteine-rich domain; Region: CCG; pfam02754 646529006167 Cysteine-rich domain; Region: CCG; pfam02754 646529006168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529006169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529006170 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 646529006171 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 646529006172 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 646529006173 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 646529006174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 646529006175 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 646529006176 substrate binding site [chemical binding]; other site 646529006177 oxyanion hole (OAH) forming residues; other site 646529006178 trimer interface [polypeptide binding]; other site 646529006179 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 646529006180 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 646529006181 dimer interface [polypeptide binding]; other site 646529006182 active site 646529006183 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 646529006184 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 646529006185 active site 646529006186 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529006187 dimerization interface [polypeptide binding]; other site 646529006188 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 646529006189 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529006190 dimer interface [polypeptide binding]; other site 646529006191 putative CheW interface [polypeptide binding]; other site 646529006192 Predicted membrane protein [Function unknown]; Region: COG3462 646529006193 Short C-terminal domain; Region: SHOCT; pfam09851 646529006194 Predicted membrane protein [Function unknown]; Region: COG3462 646529006195 Short C-terminal domain; Region: SHOCT; pfam09851 646529006196 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cl07944 646529006197 hexamer interface [polypeptide binding]; other site 646529006198 RNA binding site [nucleotide binding]; other site 646529006199 Histidine-zinc binding site [chemical binding]; other site 646529006200 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 646529006201 active sites [active] 646529006202 tetramer interface [polypeptide binding]; other site 646529006203 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 646529006204 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 646529006205 putative homodimer interface [polypeptide binding]; other site 646529006206 putative homotetramer interface [polypeptide binding]; other site 646529006207 allosteric switch controlling residues; other site 646529006208 putative metal binding site [ion binding]; other site 646529006209 putative homodimer-homodimer interface [polypeptide binding]; other site 646529006210 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 646529006211 metal-binding site [ion binding] 646529006212 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 646529006213 metal-binding site [ion binding] 646529006214 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 646529006215 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 646529006216 metal-binding site [ion binding] 646529006217 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 646529006218 Soluble P-type ATPase [General function prediction only]; Region: COG4087 646529006219 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 646529006220 metal-binding site [ion binding] 646529006221 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 646529006222 DNA polymerase IV; Reviewed; Region: PRK03103 646529006223 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 646529006224 active site 646529006225 DNA binding site [nucleotide binding] 646529006226 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 646529006227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529006228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 646529006229 Coenzyme A binding pocket [chemical binding]; other site 646529006230 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 646529006231 catalytic residues [active] 646529006232 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 646529006233 active site 646529006234 DNA polymerase IV; Validated; Region: PRK02406 646529006235 DNA binding site [nucleotide binding] 646529006236 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 646529006237 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 646529006238 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 646529006239 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 646529006240 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 646529006241 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 646529006242 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529006243 dimerization interface [polypeptide binding]; other site 646529006244 HTH domain; Region: HTH_11; pfam08279 646529006245 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 646529006246 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 646529006247 molybdopterin cofactor binding site; other site 646529006248 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 646529006249 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 646529006250 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 646529006251 molybdopterin cofactor binding site; other site 646529006252 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 646529006253 4Fe-4S binding domain; Region: Fer4; pfam00037 646529006254 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 646529006255 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 646529006256 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 646529006257 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 646529006258 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 646529006259 G1 box; other site 646529006260 putative GEF interaction site [polypeptide binding]; other site 646529006261 GTP/Mg2+ binding site [chemical binding]; other site 646529006262 Switch I region; other site 646529006263 G2 box; other site 646529006264 G3 box; other site 646529006265 Switch II region; other site 646529006266 G4 box; other site 646529006267 G5 box; other site 646529006268 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 646529006269 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 646529006270 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 646529006271 active site 646529006272 metal binding site [ion binding]; metal-binding site 646529006273 Sporulation and spore germination; Region: Germane; pfam10646 646529006274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 646529006275 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 646529006276 NlpC/P60 family; Region: NLPC_P60; pfam00877 646529006277 Methyltransferase domain; Region: Methyltransf_31; pfam13847 646529006278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529006279 S-adenosylmethionine binding site [chemical binding]; other site 646529006280 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 646529006281 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 646529006282 nucleotide binding site [chemical binding]; other site 646529006283 Acetokinase family; Region: Acetate_kinase; cl17229 646529006284 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 646529006285 short chain dehydrogenase; Provisional; Region: PRK06701 646529006286 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 646529006287 NAD binding site [chemical binding]; other site 646529006288 metal binding site [ion binding]; metal-binding site 646529006289 active site 646529006290 4Fe-4S binding domain; Region: Fer4_5; pfam12801 646529006291 4Fe-4S binding domain; Region: Fer4_5; pfam12801 646529006292 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 646529006293 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 646529006294 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 646529006295 FAD binding site [chemical binding]; other site 646529006296 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 646529006297 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 646529006298 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 646529006299 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 646529006300 PAS domain; Region: PAS; smart00091 646529006301 PAS fold; Region: PAS_4; pfam08448 646529006302 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 646529006303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529006304 Walker A motif; other site 646529006305 ATP binding site [chemical binding]; other site 646529006306 Walker B motif; other site 646529006307 arginine finger; other site 646529006308 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529006309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529006310 Response regulator receiver domain; Region: Response_reg; pfam00072 646529006311 active site 646529006312 phosphorylation site [posttranslational modification] 646529006313 intermolecular recognition site; other site 646529006314 dimerization interface [polypeptide binding]; other site 646529006315 YcbB domain; Region: YcbB; pfam08664 646529006316 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 646529006317 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 646529006318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529006319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529006320 ATP binding site [chemical binding]; other site 646529006321 Mg2+ binding site [ion binding]; other site 646529006322 G-X-G motif; other site 646529006323 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 646529006324 S1 domain; Region: S1_2; pfam13509 646529006325 S1 domain; Region: S1_2; pfam13509 646529006326 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 646529006327 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 646529006328 heat shock protein 90; Provisional; Region: PRK05218 646529006329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529006330 ATP binding site [chemical binding]; other site 646529006331 Mg2+ binding site [ion binding]; other site 646529006332 G-X-G motif; other site 646529006333 Protein of unknown function (DUF2288); Region: DUF2288; cl02399 646529006334 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 646529006335 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 646529006336 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529006337 Cysteine-rich domain; Region: CCG; pfam02754 646529006338 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 646529006339 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 646529006340 DsrC like protein; Region: DsrC; pfam04358 646529006341 HD domain; Region: HD_3; pfam13023 646529006342 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 646529006343 intersubunit interface [polypeptide binding]; other site 646529006344 active site 646529006345 Zn2+ binding site [ion binding]; other site 646529006346 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 646529006347 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 646529006348 homotetramer interface [polypeptide binding]; other site 646529006349 ligand binding site [chemical binding]; other site 646529006350 catalytic site [active] 646529006351 NAD binding site [chemical binding]; other site 646529006352 DNA topoisomerase III; Provisional; Region: PRK07726 646529006353 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 646529006354 active site 646529006355 putative interdomain interaction site [polypeptide binding]; other site 646529006356 putative metal-binding site [ion binding]; other site 646529006357 putative nucleotide binding site [chemical binding]; other site 646529006358 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 646529006359 domain I; other site 646529006360 DNA binding groove [nucleotide binding] 646529006361 phosphate binding site [ion binding]; other site 646529006362 domain II; other site 646529006363 domain III; other site 646529006364 nucleotide binding site [chemical binding]; other site 646529006365 catalytic site [active] 646529006366 domain IV; other site 646529006367 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 646529006368 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 646529006369 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 646529006370 ATP binding site [chemical binding]; other site 646529006371 Mg++ binding site [ion binding]; other site 646529006372 motif III; other site 646529006373 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529006374 nucleotide binding region [chemical binding]; other site 646529006375 ATP-binding site [chemical binding]; other site 646529006376 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 646529006377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 646529006378 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 646529006379 metal ion-dependent adhesion site (MIDAS); other site 646529006380 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 646529006381 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 646529006382 putative active site [active] 646529006383 catalytic site [active] 646529006384 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 646529006385 putative active site [active] 646529006386 catalytic site [active] 646529006387 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529006388 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529006389 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 646529006390 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 646529006391 dimer interface [polypeptide binding]; other site 646529006392 PYR/PP interface [polypeptide binding]; other site 646529006393 TPP binding site [chemical binding]; other site 646529006394 substrate binding site [chemical binding]; other site 646529006395 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 646529006396 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 646529006397 TPP-binding site [chemical binding]; other site 646529006398 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 646529006399 HEAT repeats; Region: HEAT_2; pfam13646 646529006400 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 646529006401 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 646529006402 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 646529006403 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 646529006404 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 646529006405 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 646529006406 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 646529006407 non-heme iron binding site [ion binding]; other site 646529006408 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 646529006409 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 646529006410 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529006411 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529006412 Cysteine-rich domain; Region: CCG; pfam02754 646529006413 Cysteine-rich domain; Region: CCG; pfam02754 646529006414 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 646529006415 Ligand binding site [chemical binding]; other site 646529006416 Electron transfer flavoprotein domain; Region: ETF; pfam01012 646529006417 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 646529006418 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 646529006419 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 646529006420 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 646529006421 4Fe-4S binding domain; Region: Fer4; cl02805 646529006422 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529006423 Cysteine-rich domain; Region: CCG; pfam02754 646529006424 Cysteine-rich domain; Region: CCG; pfam02754 646529006425 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 646529006426 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529006427 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 646529006428 Protein of unknown function (DUF964); Region: DUF964; pfam06133 646529006429 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529006430 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 646529006431 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 646529006432 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 646529006433 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529006434 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 646529006435 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 646529006436 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529006437 Cysteine-rich domain; Region: CCG; pfam02754 646529006438 Cysteine-rich domain; Region: CCG; pfam02754 646529006439 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 646529006440 ATP-sulfurylase; Region: ATPS; cd00517 646529006441 active site 646529006442 HXXH motif; other site 646529006443 flexible loop; other site 646529006444 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 646529006445 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529006446 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 646529006447 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 646529006448 L-aspartate oxidase; Provisional; Region: PRK06175 646529006449 Chromate transporter; Region: Chromate_transp; pfam02417 646529006450 Chromate transporter; Region: Chromate_transp; pfam02417 646529006451 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 646529006452 Ligand Binding Site [chemical binding]; other site 646529006453 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 646529006454 Ligand Binding Site [chemical binding]; other site 646529006455 Predicted permeases [General function prediction only]; Region: COG0730 646529006456 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 646529006457 Ligand Binding Site [chemical binding]; other site 646529006458 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 646529006459 Ligand Binding Site [chemical binding]; other site 646529006460 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 646529006461 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 646529006462 Sulfate transporter family; Region: Sulfate_transp; pfam00916 646529006463 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 646529006464 benzoate transport; Region: 2A0115; TIGR00895 646529006465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529006466 putative substrate translocation pore; other site 646529006467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529006468 Propionate catabolism activator; Region: PrpR_N; pfam06506 646529006469 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529006470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529006471 Walker A motif; other site 646529006472 ATP binding site [chemical binding]; other site 646529006473 Walker B motif; other site 646529006474 arginine finger; other site 646529006475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529006476 non-specific DNA binding site [nucleotide binding]; other site 646529006477 salt bridge; other site 646529006478 sequence-specific DNA binding site [nucleotide binding]; other site 646529006479 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 646529006480 CoA-transferase family III; Region: CoA_transf_3; pfam02515 646529006481 benzoate transport; Region: 2A0115; TIGR00895 646529006482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529006483 putative substrate translocation pore; other site 646529006484 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 646529006485 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 646529006486 active site 646529006487 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 646529006488 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 646529006489 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 646529006490 enoyl-CoA hydratase; Provisional; Region: PRK06688 646529006491 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 646529006492 substrate binding site [chemical binding]; other site 646529006493 oxyanion hole (OAH) forming residues; other site 646529006494 trimer interface [polypeptide binding]; other site 646529006495 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 646529006496 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 646529006497 dimer interface [polypeptide binding]; other site 646529006498 active site 646529006499 PAS domain; Region: PAS; smart00091 646529006500 PAS domain; Region: PAS_9; pfam13426 646529006501 putative active site [active] 646529006502 heme pocket [chemical binding]; other site 646529006503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529006504 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 646529006505 Walker A motif; other site 646529006506 ATP binding site [chemical binding]; other site 646529006507 Walker B motif; other site 646529006508 arginine finger; other site 646529006509 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529006510 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 646529006511 CoenzymeA binding site [chemical binding]; other site 646529006512 subunit interaction site [polypeptide binding]; other site 646529006513 PHB binding site; other site 646529006514 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 646529006515 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 646529006516 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 646529006517 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 646529006518 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 646529006519 putative metal binding site [ion binding]; other site 646529006520 tellurite resistance protein terB; Region: terB; cd07176 646529006521 putative metal binding site [ion binding]; other site 646529006522 conserved hypothetical protein; Region: TIGR02328 646529006523 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 646529006524 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 646529006525 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 646529006526 ArsC family; Region: ArsC; pfam03960 646529006527 catalytic residue [active] 646529006528 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 646529006529 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 646529006530 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 646529006531 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 646529006532 MarR family; Region: MarR_2; pfam12802 646529006533 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 646529006534 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 646529006535 active site 646529006536 FMN binding site [chemical binding]; other site 646529006537 substrate binding site [chemical binding]; other site 646529006538 putative catalytic residue [active] 646529006539 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 646529006540 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529006541 4Fe-4S binding domain; Region: Fer4; pfam00037 646529006542 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 646529006543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529006544 ATP binding site [chemical binding]; other site 646529006545 Mg2+ binding site [ion binding]; other site 646529006546 G-X-G motif; other site 646529006547 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 646529006548 anchoring element; other site 646529006549 dimer interface [polypeptide binding]; other site 646529006550 ATP binding site [chemical binding]; other site 646529006551 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 646529006552 active site 646529006553 putative metal-binding site [ion binding]; other site 646529006554 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 646529006555 DNA gyrase subunit A; Validated; Region: PRK05560 646529006556 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 646529006557 CAP-like domain; other site 646529006558 active site 646529006559 primary dimer interface [polypeptide binding]; other site 646529006560 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 646529006561 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 646529006562 Transposase domain (DUF772); Region: DUF772; pfam05598 646529006563 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 646529006564 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 646529006565 Sulfatase; Region: Sulfatase; pfam00884 646529006566 Transposase domain (DUF772); Region: DUF772; pfam05598 646529006567 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 646529006568 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 646529006569 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 646529006570 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 646529006571 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 646529006572 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 646529006573 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 646529006574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529006575 Walker A/P-loop; other site 646529006576 ATP binding site [chemical binding]; other site 646529006577 Q-loop/lid; other site 646529006578 ABC transporter signature motif; other site 646529006579 Walker B; other site 646529006580 D-loop; other site 646529006581 H-loop/switch region; other site 646529006582 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 646529006583 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 646529006584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529006585 Walker A/P-loop; other site 646529006586 ATP binding site [chemical binding]; other site 646529006587 Q-loop/lid; other site 646529006588 ABC transporter signature motif; other site 646529006589 Walker B; other site 646529006590 D-loop; other site 646529006591 H-loop/switch region; other site 646529006592 RmuC family; Region: RmuC; pfam02646 646529006593 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 646529006594 dimer interface [polypeptide binding]; other site 646529006595 substrate binding site [chemical binding]; other site 646529006596 ATP binding site [chemical binding]; other site 646529006597 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 646529006598 substrate binding site [chemical binding]; other site 646529006599 multimerization interface [polypeptide binding]; other site 646529006600 ATP binding site [chemical binding]; other site 646529006601 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 646529006602 thiamine phosphate binding site [chemical binding]; other site 646529006603 active site 646529006604 pyrophosphate binding site [ion binding]; other site 646529006605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 646529006606 NAD(P) binding site [chemical binding]; other site 646529006607 active site 646529006608 Transposase [DNA replication, recombination, and repair]; Region: COG5421 646529006609 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 646529006610 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 646529006611 Putative Fe-S cluster; Region: FeS; pfam04060 646529006612 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 646529006613 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 646529006614 MarR family; Region: MarR; pfam01047 646529006615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529006616 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529006617 putative substrate translocation pore; other site 646529006618 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529006619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529006620 active site 646529006621 phosphorylation site [posttranslational modification] 646529006622 intermolecular recognition site; other site 646529006623 dimerization interface [polypeptide binding]; other site 646529006624 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529006625 DNA binding site [nucleotide binding] 646529006626 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529006627 dimerization interface [polypeptide binding]; other site 646529006628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529006629 dimer interface [polypeptide binding]; other site 646529006630 phosphorylation site [posttranslational modification] 646529006631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529006632 ATP binding site [chemical binding]; other site 646529006633 Mg2+ binding site [ion binding]; other site 646529006634 G-X-G motif; other site 646529006635 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 646529006636 putative active site [active] 646529006637 putative metal binding site [ion binding]; other site 646529006638 Propionate catabolism activator; Region: PrpR_N; pfam06506 646529006639 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529006640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529006641 Walker A motif; other site 646529006642 ATP binding site [chemical binding]; other site 646529006643 Walker B motif; other site 646529006644 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529006645 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 646529006646 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 646529006647 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 646529006648 CoA binding domain; Region: CoA_binding; pfam02629 646529006649 CoA-ligase; Region: Ligase_CoA; pfam00549 646529006650 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 646529006651 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 646529006652 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 646529006653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529006654 homodimer interface [polypeptide binding]; other site 646529006655 catalytic residue [active] 646529006656 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 646529006657 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 646529006658 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 646529006659 dimerization interface [polypeptide binding]; other site 646529006660 ATP binding site [chemical binding]; other site 646529006661 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 646529006662 dimerization interface [polypeptide binding]; other site 646529006663 ATP binding site [chemical binding]; other site 646529006664 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 646529006665 putative active site [active] 646529006666 catalytic triad [active] 646529006667 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 646529006668 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 646529006669 active site clefts [active] 646529006670 zinc binding site [ion binding]; other site 646529006671 dimer interface [polypeptide binding]; other site 646529006672 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 646529006673 peptidase T-like protein; Region: PepT-like; TIGR01883 646529006674 metal binding site [ion binding]; metal-binding site 646529006675 putative dimer interface [polypeptide binding]; other site 646529006676 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 646529006677 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 646529006678 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 646529006679 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 646529006680 Walker A/P-loop; other site 646529006681 ATP binding site [chemical binding]; other site 646529006682 Q-loop/lid; other site 646529006683 ABC transporter signature motif; other site 646529006684 Walker B; other site 646529006685 D-loop; other site 646529006686 H-loop/switch region; other site 646529006687 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 646529006688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529006689 putative PBP binding loops; other site 646529006690 dimer interface [polypeptide binding]; other site 646529006691 ABC-ATPase subunit interface; other site 646529006692 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 646529006693 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 646529006694 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 646529006695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529006696 Walker A/P-loop; other site 646529006697 ATP binding site [chemical binding]; other site 646529006698 Q-loop/lid; other site 646529006699 ABC transporter signature motif; other site 646529006700 Walker B; other site 646529006701 D-loop; other site 646529006702 H-loop/switch region; other site 646529006703 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 646529006704 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 646529006705 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 646529006706 Walker A/P-loop; other site 646529006707 ATP binding site [chemical binding]; other site 646529006708 Q-loop/lid; other site 646529006709 ABC transporter signature motif; other site 646529006710 Walker B; other site 646529006711 D-loop; other site 646529006712 H-loop/switch region; other site 646529006713 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 646529006714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529006715 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529006716 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 646529006717 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 646529006718 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 646529006719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529006720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529006721 phosphoenolpyruvate synthase; Validated; Region: PRK06241 646529006722 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 646529006723 Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding...; Region: H2A; cl00074 646529006724 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 646529006725 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 646529006726 Acyltransferase family; Region: Acyl_transf_3; pfam01757 646529006727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529006728 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529006729 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 646529006730 NlpC/P60 family; Region: NLPC_P60; pfam00877 646529006731 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 646529006732 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529006733 DNA-binding site [nucleotide binding]; DNA binding site 646529006734 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 646529006735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529006736 homodimer interface [polypeptide binding]; other site 646529006737 catalytic residue [active] 646529006738 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 646529006739 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 646529006740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529006741 homodimer interface [polypeptide binding]; other site 646529006742 catalytic residue [active] 646529006743 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 646529006744 aspartate racemase; Region: asp_race; TIGR00035 646529006745 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 646529006746 Acyltransferase family; Region: Acyl_transf_3; pfam01757 646529006747 MarR family; Region: MarR; pfam01047 646529006748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529006749 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529006750 putative substrate translocation pore; other site 646529006751 CHASE4 domain; Region: CHASE4; pfam05228 646529006752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529006753 dimerization interface [polypeptide binding]; other site 646529006754 PAS domain S-box; Region: sensory_box; TIGR00229 646529006755 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 646529006756 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529006757 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529006758 metal binding site [ion binding]; metal-binding site 646529006759 active site 646529006760 I-site; other site 646529006761 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 646529006762 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529006763 Zn2+ binding site [ion binding]; other site 646529006764 Mg2+ binding site [ion binding]; other site 646529006765 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 646529006766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529006767 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529006768 putative substrate translocation pore; other site 646529006769 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 646529006770 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 646529006771 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 646529006772 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 646529006773 Walker A/P-loop; other site 646529006774 ATP binding site [chemical binding]; other site 646529006775 Q-loop/lid; other site 646529006776 ABC transporter signature motif; other site 646529006777 Walker B; other site 646529006778 D-loop; other site 646529006779 H-loop/switch region; other site 646529006780 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 646529006781 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 646529006782 Walker A/P-loop; other site 646529006783 ATP binding site [chemical binding]; other site 646529006784 Q-loop/lid; other site 646529006785 ABC transporter signature motif; other site 646529006786 Walker B; other site 646529006787 D-loop; other site 646529006788 H-loop/switch region; other site 646529006789 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 646529006790 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 646529006791 YtxH-like protein; Region: YtxH; pfam12732 646529006792 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 646529006793 active site 646529006794 putative homodimer interface [polypeptide binding]; other site 646529006795 SAM binding site [chemical binding]; other site 646529006796 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 646529006797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529006798 S-adenosylmethionine binding site [chemical binding]; other site 646529006799 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 646529006800 SAM binding site [chemical binding]; other site 646529006801 active site 646529006802 homodimer interface [polypeptide binding]; other site 646529006803 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 646529006804 active site 646529006805 SAM binding site [chemical binding]; other site 646529006806 homodimer interface [polypeptide binding]; other site 646529006807 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 646529006808 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 646529006809 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 646529006810 homodimer interface [polypeptide binding]; other site 646529006811 active site 646529006812 SAM binding site [chemical binding]; other site 646529006813 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 646529006814 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 646529006815 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 646529006816 putative active site [active] 646529006817 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 646529006818 Precorrin-8X methylmutase; Region: CbiC; pfam02570 646529006819 cobyric acid synthase; Provisional; Region: PRK00784 646529006820 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 646529006821 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 646529006822 catalytic triad [active] 646529006823 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 646529006824 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 646529006825 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 646529006826 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 646529006827 catalytic triad [active] 646529006828 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 646529006829 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 646529006830 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 646529006831 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 646529006832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529006833 homodimer interface [polypeptide binding]; other site 646529006834 catalytic residue [active] 646529006835 L-lactate permease; Region: Lactate_perm; cl00701 646529006836 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 646529006837 Uncharacterized conserved protein [Function unknown]; Region: COG1359 646529006838 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 646529006839 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 646529006840 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 646529006841 active site 646529006842 DNA binding site [nucleotide binding] 646529006843 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 646529006844 DNA binding site [nucleotide binding] 646529006845 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 646529006846 nucleotide binding site [chemical binding]; other site 646529006847 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 646529006848 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 646529006849 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 646529006850 Transposase domain (DUF772); Region: DUF772; pfam05598 646529006851 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 646529006852 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529006853 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 646529006854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 646529006855 Helix-turn-helix domain; Region: HTH_18; pfam12833 646529006856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 646529006857 dimerization interface [polypeptide binding]; other site 646529006858 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529006859 dimer interface [polypeptide binding]; other site 646529006860 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 646529006861 putative CheW interface [polypeptide binding]; other site 646529006862 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 646529006863 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 646529006864 active site 646529006865 catalytic residues [active] 646529006866 metal binding site [ion binding]; metal-binding site 646529006867 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 646529006868 CmuC_like. Proteins similar to the putative corrinoid methyltransferase CmuC. Its function has been inferred from sequence similarity to the methyltransferases CmuA and MtaA. Mutants of Methylobacterium sp. disrupted in cmuC and purU appear deficient in...; Region: CmuC_like; cd03309 646529006869 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 646529006870 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 646529006871 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 646529006872 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 646529006873 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 646529006874 active site 646529006875 FMN binding site [chemical binding]; other site 646529006876 substrate binding site [chemical binding]; other site 646529006877 3Fe-4S cluster binding site [ion binding]; other site 646529006878 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 646529006879 active site 646529006880 catalytic triad [active] 646529006881 oxyanion hole [active] 646529006882 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 646529006883 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 646529006884 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 646529006885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529006886 Walker A/P-loop; other site 646529006887 ATP binding site [chemical binding]; other site 646529006888 Q-loop/lid; other site 646529006889 ABC transporter signature motif; other site 646529006890 Walker B; other site 646529006891 D-loop; other site 646529006892 H-loop/switch region; other site 646529006893 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 646529006894 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 646529006895 DNA binding residues [nucleotide binding] 646529006896 putative dimer interface [polypeptide binding]; other site 646529006897 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 646529006898 myosin-cross-reactive antigen; Provisional; Region: PRK13977 646529006899 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 646529006900 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 646529006901 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 646529006902 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 646529006903 Transposase domain (DUF772); Region: DUF772; pfam05598 646529006904 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 646529006905 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529006906 A new structural DNA glycosylase; Region: AlkD_like; cd06561 646529006907 active site 646529006908 SnoaL-like domain; Region: SnoaL_3; pfam13474 646529006909 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 646529006910 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 646529006911 active site 646529006912 tetramer interface [polypeptide binding]; other site 646529006913 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 646529006914 active site 646529006915 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 646529006916 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 646529006917 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 646529006918 thiS-thiF/thiG interaction site; other site 646529006919 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 646529006920 ThiS interaction site; other site 646529006921 putative active site [active] 646529006922 tetramer interface [polypeptide binding]; other site 646529006923 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 646529006924 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529006925 FeS/SAM binding site; other site 646529006926 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 646529006927 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 646529006928 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 646529006929 ATP binding site [chemical binding]; other site 646529006930 substrate interface [chemical binding]; other site 646529006931 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 646529006932 thiamine phosphate binding site [chemical binding]; other site 646529006933 active site 646529006934 pyrophosphate binding site [ion binding]; other site 646529006935 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 646529006936 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 646529006937 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 646529006938 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 646529006939 DXD motif; other site 646529006940 PilZ domain; Region: PilZ; pfam07238 646529006941 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529006942 Zn2+ binding site [ion binding]; other site 646529006943 Mg2+ binding site [ion binding]; other site 646529006944 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 646529006945 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529006946 Zn2+ binding site [ion binding]; other site 646529006947 Mg2+ binding site [ion binding]; other site 646529006948 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 646529006949 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 646529006950 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 646529006951 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 646529006952 GEMM cis-regulatory element 646529006953 drug efflux system protein MdtG; Provisional; Region: PRK09874 646529006954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529006955 putative substrate translocation pore; other site 646529006956 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 646529006957 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 646529006958 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 646529006959 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 646529006960 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529006961 FeS/SAM binding site; other site 646529006962 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 646529006963 SEC-C motif; Region: SEC-C; pfam02810 646529006964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529006965 PAS fold; Region: PAS_3; pfam08447 646529006966 putative active site [active] 646529006967 heme pocket [chemical binding]; other site 646529006968 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529006969 putative active site [active] 646529006970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529006971 heme pocket [chemical binding]; other site 646529006972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529006973 dimer interface [polypeptide binding]; other site 646529006974 phosphorylation site [posttranslational modification] 646529006975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529006976 ATP binding site [chemical binding]; other site 646529006977 Mg2+ binding site [ion binding]; other site 646529006978 G-X-G motif; other site 646529006979 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 646529006980 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529006981 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529006982 metal binding site [ion binding]; metal-binding site 646529006983 active site 646529006984 I-site; other site 646529006985 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 646529006986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 646529006987 NADH(P)-binding; Region: NAD_binding_10; pfam13460 646529006988 NAD(P) binding site [chemical binding]; other site 646529006989 active site 646529006990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529006991 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 646529006992 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 646529006993 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 646529006994 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 646529006995 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 646529006996 Mga helix-turn-helix domain; Region: Mga; pfam05043 646529006997 HTH domain; Region: HTH_11; pfam08279 646529006998 PRD domain; Region: PRD; pfam00874 646529006999 PRD domain; Region: PRD; pfam00874 646529007000 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 646529007001 active site 646529007002 P-loop; other site 646529007003 phosphorylation site [posttranslational modification] 646529007004 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 646529007005 active site 646529007006 phosphorylation site [posttranslational modification] 646529007007 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 646529007008 active site 646529007009 P-loop; other site 646529007010 phosphorylation site [posttranslational modification] 646529007011 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 646529007012 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 646529007013 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 646529007014 methionine cluster; other site 646529007015 active site 646529007016 phosphorylation site [posttranslational modification] 646529007017 metal binding site [ion binding]; metal-binding site 646529007018 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 646529007019 dimerization domain swap beta strand [polypeptide binding]; other site 646529007020 regulatory protein interface [polypeptide binding]; other site 646529007021 active site 646529007022 regulatory phosphorylation site [posttranslational modification]; other site 646529007023 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 646529007024 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 646529007025 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 646529007026 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 646529007027 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 646529007028 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 646529007029 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 646529007030 Cysteine-rich domain; Region: CCG; pfam02754 646529007031 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 646529007032 Cysteine-rich domain; Region: CCG; pfam02754 646529007033 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 646529007034 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 646529007035 putative glutamate synthase subunit beta; Provisional; Region: PRK12770 646529007036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 646529007037 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 646529007038 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 646529007039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 646529007040 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 646529007041 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 646529007042 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 646529007043 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 646529007044 FAD binding site [chemical binding]; other site 646529007045 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 646529007046 Ligand Binding Site [chemical binding]; other site 646529007047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529007048 S-adenosylmethionine binding site [chemical binding]; other site 646529007049 Predicted transcriptional regulators [Transcription]; Region: COG1695 646529007050 Transcriptional regulator PadR-like family; Region: PadR; cl17335 646529007051 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 646529007052 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 646529007053 intracellular protease, PfpI family; Region: PfpI; TIGR01382 646529007054 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 646529007055 conserved cys residue [active] 646529007056 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 646529007057 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 646529007058 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 646529007059 Predicted membrane protein [Function unknown]; Region: COG3766 646529007060 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 646529007061 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 646529007062 Putative cyclase; Region: Cyclase; pfam04199 646529007063 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529007064 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 646529007065 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 646529007066 FtsX-like permease family; Region: FtsX; pfam02687 646529007067 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 646529007068 FtsX-like permease family; Region: FtsX; pfam02687 646529007069 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 646529007070 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 646529007071 Walker A/P-loop; other site 646529007072 ATP binding site [chemical binding]; other site 646529007073 Q-loop/lid; other site 646529007074 ABC transporter signature motif; other site 646529007075 Walker B; other site 646529007076 D-loop; other site 646529007077 H-loop/switch region; other site 646529007078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529007079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529007080 dimer interface [polypeptide binding]; other site 646529007081 phosphorylation site [posttranslational modification] 646529007082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529007083 ATP binding site [chemical binding]; other site 646529007084 Mg2+ binding site [ion binding]; other site 646529007085 G-X-G motif; other site 646529007086 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529007087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529007088 active site 646529007089 phosphorylation site [posttranslational modification] 646529007090 intermolecular recognition site; other site 646529007091 dimerization interface [polypeptide binding]; other site 646529007092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529007093 DNA binding site [nucleotide binding] 646529007094 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 646529007095 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 646529007096 conserved cys residue [active] 646529007097 Predicted transcriptional regulator [Transcription]; Region: COG2378 646529007098 HTH domain; Region: HTH_11; pfam08279 646529007099 WYL domain; Region: WYL; pfam13280 646529007100 Amidohydrolase; Region: Amidohydro_2; pfam04909 646529007101 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 646529007102 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 646529007103 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 646529007104 active site 646529007105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 646529007106 dimerization interface [polypeptide binding]; other site 646529007107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529007108 dimer interface [polypeptide binding]; other site 646529007109 phosphorylation site [posttranslational modification] 646529007110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529007111 ATP binding site [chemical binding]; other site 646529007112 Mg2+ binding site [ion binding]; other site 646529007113 G-X-G motif; other site 646529007114 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529007115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529007116 active site 646529007117 phosphorylation site [posttranslational modification] 646529007118 intermolecular recognition site; other site 646529007119 dimerization interface [polypeptide binding]; other site 646529007120 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529007121 DNA binding site [nucleotide binding] 646529007122 drug efflux system protein MdtG; Provisional; Region: PRK09874 646529007123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529007124 putative substrate translocation pore; other site 646529007125 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 646529007126 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 646529007127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529007128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529007129 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 646529007130 Chloramphenicol acetyltransferase; Region: CAT; smart01059 646529007131 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 646529007132 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 646529007133 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 646529007134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529007135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529007136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529007137 Coenzyme A binding pocket [chemical binding]; other site 646529007138 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 646529007139 active site 646529007140 catalytic triad [active] 646529007141 oxyanion hole [active] 646529007142 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 646529007143 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 646529007144 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 646529007145 TIGR04076 family protein; Region: TIGR04076 646529007146 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 646529007147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529007148 Coenzyme A binding pocket [chemical binding]; other site 646529007149 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 646529007150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529007151 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 646529007152 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529007153 transposase; Provisional; Region: PRK06526 646529007154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529007155 Walker A motif; other site 646529007156 ATP binding site [chemical binding]; other site 646529007157 Walker B motif; other site 646529007158 arginine finger; other site 646529007159 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 646529007160 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 646529007161 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 646529007162 Int/Topo IB signature motif; other site 646529007163 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 646529007164 active site 646529007165 DNA binding site [nucleotide binding] 646529007166 Int/Topo IB signature motif; other site 646529007167 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 646529007168 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 646529007169 active site 646529007170 DNA binding site [nucleotide binding] 646529007171 Int/Topo IB signature motif; other site 646529007172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 646529007173 Helix-turn-helix domain; Region: HTH_28; pfam13518 646529007174 Transposase; Region: HTH_Tnp_1; cl17663 646529007175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 646529007176 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 646529007177 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 646529007178 active site 646529007179 catalytic tetrad [active] 646529007180 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 646529007181 metal-dependent hydrolase; Provisional; Region: PRK13291 646529007182 DinB superfamily; Region: DinB_2; pfam12867 646529007183 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 646529007184 putative acyltransferase; Provisional; Region: PRK05790 646529007185 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 646529007186 dimer interface [polypeptide binding]; other site 646529007187 active site 646529007188 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 646529007189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 646529007190 NAD(P) binding site [chemical binding]; other site 646529007191 active site 646529007192 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 646529007193 Coenzyme A transferase; Region: CoA_trans; smart00882 646529007194 Coenzyme A transferase; Region: CoA_trans; cl17247 646529007195 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529007196 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529007197 putative active site [active] 646529007198 heme pocket [chemical binding]; other site 646529007199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529007200 Walker A motif; other site 646529007201 ATP binding site [chemical binding]; other site 646529007202 Walker B motif; other site 646529007203 arginine finger; other site 646529007204 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529007205 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 646529007206 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 646529007207 EamA-like transporter family; Region: EamA; pfam00892 646529007208 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 646529007209 EamA-like transporter family; Region: EamA; pfam00892 646529007210 Flavodoxin domain; Region: Flavodoxin_5; cl17428 646529007211 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 646529007212 4Fe-4S binding domain; Region: Fer4; cl02805 646529007213 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529007214 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 646529007215 active site 646529007216 metal binding site [ion binding]; metal-binding site 646529007217 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 646529007218 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 646529007219 active site 646529007220 DNA binding site [nucleotide binding] 646529007221 Int/Topo IB signature motif; other site 646529007222 methionine sulfoxide reductase A; Provisional; Region: PRK14054 646529007223 methionine sulfoxide reductase B; Provisional; Region: PRK00222 646529007224 SelR domain; Region: SelR; pfam01641 646529007225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529007226 S-adenosylmethionine binding site [chemical binding]; other site 646529007227 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 646529007228 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 646529007229 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 646529007230 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 646529007231 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529007232 Cysteine-rich domain; Region: CCG; pfam02754 646529007233 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 646529007234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 646529007235 catalytic residue [active] 646529007236 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529007237 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 646529007238 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 646529007239 FAD binding pocket [chemical binding]; other site 646529007240 FAD binding motif [chemical binding]; other site 646529007241 phosphate binding motif [ion binding]; other site 646529007242 beta-alpha-beta structure motif; other site 646529007243 NAD binding pocket [chemical binding]; other site 646529007244 Iron coordination center [ion binding]; other site 646529007245 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 646529007246 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 646529007247 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 646529007248 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 646529007249 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 646529007250 4Fe-4S binding domain; Region: Fer4; pfam00037 646529007251 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529007252 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 646529007253 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 646529007254 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 646529007255 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 646529007256 Part of AAA domain; Region: AAA_19; pfam13245 646529007257 Family description; Region: UvrD_C_2; pfam13538 646529007258 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 646529007259 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 646529007260 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 646529007261 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 646529007262 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 646529007263 NodB motif; other site 646529007264 active site 646529007265 catalytic site [active] 646529007266 metal binding site [ion binding]; metal-binding site 646529007267 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 646529007268 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 646529007269 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529007270 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529007271 metal binding site [ion binding]; metal-binding site 646529007272 active site 646529007273 I-site; other site 646529007274 Uncharacterized conserved protein [Function unknown]; Region: COG1284 646529007275 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 646529007276 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 646529007277 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 646529007278 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 646529007279 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 646529007280 putative active site [active] 646529007281 catalytic site [active] 646529007282 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 646529007283 putative active site [active] 646529007284 catalytic site [active] 646529007285 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 646529007286 EamA-like transporter family; Region: EamA; pfam00892 646529007287 EamA-like transporter family; Region: EamA; pfam00892 646529007288 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 646529007289 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 646529007290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529007291 active site 646529007292 phosphorylation site [posttranslational modification] 646529007293 intermolecular recognition site; other site 646529007294 dimerization interface [polypeptide binding]; other site 646529007295 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 646529007296 DNA binding residues [nucleotide binding] 646529007297 dimerization interface [polypeptide binding]; other site 646529007298 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 646529007299 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 646529007300 Histidine kinase; Region: HisKA_3; pfam07730 646529007301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529007302 ATP binding site [chemical binding]; other site 646529007303 Mg2+ binding site [ion binding]; other site 646529007304 G-X-G motif; other site 646529007305 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 646529007306 nucleoside/Zn binding site; other site 646529007307 dimer interface [polypeptide binding]; other site 646529007308 catalytic motif [active] 646529007309 Ion channel; Region: Ion_trans_2; pfam07885 646529007310 Sensory domain found in PocR; Region: PocR; pfam10114 646529007311 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 646529007312 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529007313 putative active site [active] 646529007314 heme pocket [chemical binding]; other site 646529007315 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529007316 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529007317 metal binding site [ion binding]; metal-binding site 646529007318 active site 646529007319 I-site; other site 646529007320 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 646529007321 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529007322 Zn2+ binding site [ion binding]; other site 646529007323 Mg2+ binding site [ion binding]; other site 646529007324 PAS domain S-box; Region: sensory_box; TIGR00229 646529007325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 646529007326 dimer interface [polypeptide binding]; other site 646529007327 phosphorylation site [posttranslational modification] 646529007328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529007329 ATP binding site [chemical binding]; other site 646529007330 Mg2+ binding site [ion binding]; other site 646529007331 G-X-G motif; other site 646529007332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529007333 Response regulator receiver domain; Region: Response_reg; pfam00072 646529007334 active site 646529007335 phosphorylation site [posttranslational modification] 646529007336 intermolecular recognition site; other site 646529007337 dimerization interface [polypeptide binding]; other site 646529007338 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 646529007339 PAS fold; Region: PAS_4; pfam08448 646529007340 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529007341 putative active site [active] 646529007342 heme pocket [chemical binding]; other site 646529007343 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 646529007344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529007345 putative active site [active] 646529007346 heme pocket [chemical binding]; other site 646529007347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529007348 dimer interface [polypeptide binding]; other site 646529007349 phosphorylation site [posttranslational modification] 646529007350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529007351 ATP binding site [chemical binding]; other site 646529007352 Mg2+ binding site [ion binding]; other site 646529007353 G-X-G motif; other site 646529007354 Response regulator receiver domain; Region: Response_reg; pfam00072 646529007355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529007356 active site 646529007357 phosphorylation site [posttranslational modification] 646529007358 intermolecular recognition site; other site 646529007359 dimerization interface [polypeptide binding]; other site 646529007360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 646529007361 Histidine kinase; Region: His_kinase; pfam06580 646529007362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529007363 ATP binding site [chemical binding]; other site 646529007364 Mg2+ binding site [ion binding]; other site 646529007365 G-X-G motif; other site 646529007366 H+ Antiporter protein; Region: 2A0121; TIGR00900 646529007367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529007368 putative substrate translocation pore; other site 646529007369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529007370 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 646529007371 putative substrate translocation pore; other site 646529007372 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 646529007373 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 646529007374 Sulfate transporter family; Region: Sulfate_transp; pfam00916 646529007375 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 646529007376 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 646529007377 Transposase domain (DUF772); Region: DUF772; pfam05598 646529007378 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 646529007379 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529007380 Response regulator receiver domain; Region: Response_reg; pfam00072 646529007381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529007382 active site 646529007383 phosphorylation site [posttranslational modification] 646529007384 intermolecular recognition site; other site 646529007385 dimerization interface [polypeptide binding]; other site 646529007386 Response regulator receiver domain; Region: Response_reg; pfam00072 646529007387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529007388 active site 646529007389 phosphorylation site [posttranslational modification] 646529007390 intermolecular recognition site; other site 646529007391 dimerization interface [polypeptide binding]; other site 646529007392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529007393 dimer interface [polypeptide binding]; other site 646529007394 phosphorylation site [posttranslational modification] 646529007395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529007396 ATP binding site [chemical binding]; other site 646529007397 Mg2+ binding site [ion binding]; other site 646529007398 G-X-G motif; other site 646529007399 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 646529007400 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 646529007401 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 646529007402 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 646529007403 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 646529007404 GAF domain; Region: GAF; cl17456 646529007405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529007406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529007407 dimer interface [polypeptide binding]; other site 646529007408 phosphorylation site [posttranslational modification] 646529007409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529007410 ATP binding site [chemical binding]; other site 646529007411 Mg2+ binding site [ion binding]; other site 646529007412 G-X-G motif; other site 646529007413 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 646529007414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529007415 active site 646529007416 phosphorylation site [posttranslational modification] 646529007417 intermolecular recognition site; other site 646529007418 dimerization interface [polypeptide binding]; other site 646529007419 Short C-terminal domain; Region: SHOCT; pfam09851 646529007420 Heavy-metal-associated domain; Region: HMA; pfam00403 646529007421 metal-binding site [ion binding] 646529007422 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 646529007423 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 646529007424 Soluble P-type ATPase [General function prediction only]; Region: COG4087 646529007425 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 646529007426 dimerization interface [polypeptide binding]; other site 646529007427 putative DNA binding site [nucleotide binding]; other site 646529007428 putative Zn2+ binding site [ion binding]; other site 646529007429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529007430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529007431 putative substrate translocation pore; other site 646529007432 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 646529007433 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 646529007434 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 646529007435 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 646529007436 active site 646529007437 NAD binding site [chemical binding]; other site 646529007438 metal binding site [ion binding]; metal-binding site 646529007439 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 646529007440 Rubrerythrin [Energy production and conversion]; Region: COG1592 646529007441 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 646529007442 binuclear metal center [ion binding]; other site 646529007443 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 646529007444 iron binding site [ion binding]; other site 646529007445 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 646529007446 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 646529007447 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 646529007448 Hemerythrin-like domain; Region: Hr-like; cd12108 646529007449 Fe binding site [ion binding]; other site 646529007450 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 646529007451 dinuclear metal binding motif [ion binding]; other site 646529007452 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 646529007453 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 646529007454 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 646529007455 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 646529007456 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 646529007457 catalytic loop [active] 646529007458 iron binding site [ion binding]; other site 646529007459 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 646529007460 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 646529007461 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 646529007462 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 646529007463 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529007464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529007465 putative active site [active] 646529007466 heme pocket [chemical binding]; other site 646529007467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529007468 Walker A motif; other site 646529007469 ATP binding site [chemical binding]; other site 646529007470 Walker B motif; other site 646529007471 arginine finger; other site 646529007472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529007473 phosphorylation site [posttranslational modification] 646529007474 intermolecular recognition site; other site 646529007475 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 646529007476 glutamate dehydrogenase; Provisional; Region: PRK09414 646529007477 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 646529007478 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 646529007479 tetramerization interface [polypeptide binding]; other site 646529007480 NAD(P) binding site [chemical binding]; other site 646529007481 catalytic residues [active] 646529007482 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 646529007483 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 646529007484 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 646529007485 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 646529007486 inhibitor-cofactor binding pocket; inhibition site 646529007487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529007488 catalytic residue [active] 646529007489 PAS domain; Region: PAS; smart00091 646529007490 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529007491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529007492 Walker A motif; other site 646529007493 ATP binding site [chemical binding]; other site 646529007494 Walker B motif; other site 646529007495 arginine finger; other site 646529007496 glutamate dehydrogenase; Provisional; Region: PRK09414 646529007497 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 646529007498 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 646529007499 NAD(P) binding site [chemical binding]; other site 646529007500 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 646529007501 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 646529007502 inhibitor-cofactor binding pocket; inhibition site 646529007503 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529007504 catalytic residue [active] 646529007505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4306 646529007506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 646529007507 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 646529007508 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 646529007509 metal ion-dependent adhesion site (MIDAS); other site 646529007510 Transposase domain (DUF772); Region: DUF772; pfam05598 646529007511 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 646529007512 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 646529007513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529007514 Walker A motif; other site 646529007515 ATP binding site [chemical binding]; other site 646529007516 Walker B motif; other site 646529007517 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 646529007518 putative alcohol dehydrogenase; Provisional; Region: PRK09860 646529007519 dimer interface [polypeptide binding]; other site 646529007520 active site 646529007521 metal binding site [ion binding]; metal-binding site 646529007522 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 646529007523 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 646529007524 XdhC Rossmann domain; Region: XdhC_C; pfam13478 646529007525 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 646529007526 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 646529007527 acyl-activating enzyme (AAE) consensus motif; other site 646529007528 active site 646529007529 AMP binding site [chemical binding]; other site 646529007530 CoA binding site [chemical binding]; other site 646529007531 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 646529007532 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529007533 FeS/SAM binding site; other site 646529007534 Methyltransferase domain; Region: Methyltransf_31; pfam13847 646529007535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529007536 S-adenosylmethionine binding site [chemical binding]; other site 646529007537 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 646529007538 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 646529007539 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529007540 Cysteine-rich domain; Region: CCG; pfam02754 646529007541 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 646529007542 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 646529007543 catalytic loop [active] 646529007544 iron binding site [ion binding]; other site 646529007545 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 646529007546 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 646529007547 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 646529007548 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 646529007549 putative MPT binding site; other site 646529007550 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 646529007551 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529007552 putative active site [active] 646529007553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529007554 Walker A motif; other site 646529007555 ATP binding site [chemical binding]; other site 646529007556 Walker B motif; other site 646529007557 arginine finger; other site 646529007558 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529007559 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 646529007560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 646529007561 NAD(P) binding site [chemical binding]; other site 646529007562 active site 646529007563 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 646529007564 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 646529007565 Walker A/P-loop; other site 646529007566 ATP binding site [chemical binding]; other site 646529007567 Q-loop/lid; other site 646529007568 ABC transporter signature motif; other site 646529007569 Walker B; other site 646529007570 D-loop; other site 646529007571 H-loop/switch region; other site 646529007572 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 646529007573 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 646529007574 TM-ABC transporter signature motif; other site 646529007575 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 646529007576 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 646529007577 Walker A/P-loop; other site 646529007578 ATP binding site [chemical binding]; other site 646529007579 Q-loop/lid; other site 646529007580 ABC transporter signature motif; other site 646529007581 Walker B; other site 646529007582 D-loop; other site 646529007583 H-loop/switch region; other site 646529007584 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 646529007585 TM-ABC transporter signature motif; other site 646529007586 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 646529007587 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 646529007588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529007589 PAS domain; Region: PAS_9; pfam13426 646529007590 putative active site [active] 646529007591 heme pocket [chemical binding]; other site 646529007592 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 646529007593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529007594 Walker A motif; other site 646529007595 ATP binding site [chemical binding]; other site 646529007596 Walker B motif; other site 646529007597 arginine finger; other site 646529007598 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529007599 putative acyltransferase; Provisional; Region: PRK05790 646529007600 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 646529007601 dimer interface [polypeptide binding]; other site 646529007602 active site 646529007603 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 646529007604 dimer interaction site [polypeptide binding]; other site 646529007605 substrate-binding tunnel; other site 646529007606 active site 646529007607 catalytic site [active] 646529007608 substrate binding site [chemical binding]; other site 646529007609 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 646529007610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 646529007611 NAD(P) binding site [chemical binding]; other site 646529007612 active site 646529007613 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 646529007614 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 646529007615 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 646529007616 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 646529007617 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 646529007618 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 646529007619 dimer interface [polypeptide binding]; other site 646529007620 active site 646529007621 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 646529007622 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 646529007623 G1 box; other site 646529007624 putative GEF interaction site [polypeptide binding]; other site 646529007625 GTP/Mg2+ binding site [chemical binding]; other site 646529007626 Switch I region; other site 646529007627 G2 box; other site 646529007628 G3 box; other site 646529007629 Switch II region; other site 646529007630 G4 box; other site 646529007631 G5 box; other site 646529007632 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 646529007633 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 646529007634 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 646529007635 YacP-like NYN domain; Region: NYN_YacP; pfam05991 646529007636 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529007637 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529007638 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529007639 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 646529007640 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 646529007641 4Fe-4S binding domain; Region: Fer4; cl02805 646529007642 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529007643 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 646529007644 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 646529007645 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 646529007646 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 646529007647 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 646529007648 Beta-Casp domain; Region: Beta-Casp; smart01027 646529007649 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 646529007650 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 646529007651 Ligand Binding Site [chemical binding]; other site 646529007652 Chromate transporter; Region: Chromate_transp; pfam02417 646529007653 Chromate transporter; Region: Chromate_transp; pfam02417 646529007654 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 646529007655 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 646529007656 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 646529007657 Penicillinase repressor; Region: Pencillinase_R; pfam03965 646529007658 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 646529007659 Protein of unknown function, DUF606; Region: DUF606; pfam04657 646529007660 Protein of unknown function, DUF606; Region: DUF606; pfam04657 646529007661 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 646529007662 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 646529007663 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 646529007664 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 646529007665 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 646529007666 peptide binding site [polypeptide binding]; other site 646529007667 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 646529007668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529007669 dimer interface [polypeptide binding]; other site 646529007670 conserved gate region; other site 646529007671 putative PBP binding loops; other site 646529007672 ABC-ATPase subunit interface; other site 646529007673 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 646529007674 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 646529007675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529007676 dimer interface [polypeptide binding]; other site 646529007677 conserved gate region; other site 646529007678 putative PBP binding loops; other site 646529007679 ABC-ATPase subunit interface; other site 646529007680 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 646529007681 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 646529007682 Walker A/P-loop; other site 646529007683 ATP binding site [chemical binding]; other site 646529007684 Q-loop/lid; other site 646529007685 ABC transporter signature motif; other site 646529007686 Walker B; other site 646529007687 D-loop; other site 646529007688 H-loop/switch region; other site 646529007689 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 646529007690 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 646529007691 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 646529007692 Walker A/P-loop; other site 646529007693 ATP binding site [chemical binding]; other site 646529007694 Q-loop/lid; other site 646529007695 ABC transporter signature motif; other site 646529007696 Walker B; other site 646529007697 D-loop; other site 646529007698 H-loop/switch region; other site 646529007699 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 646529007700 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 646529007701 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 646529007702 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 646529007703 classical (c) SDRs; Region: SDR_c; cd05233 646529007704 NAD(P) binding site [chemical binding]; other site 646529007705 active site 646529007706 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 646529007707 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 646529007708 intersubunit interface [polypeptide binding]; other site 646529007709 active site 646529007710 zinc binding site [ion binding]; other site 646529007711 Na+ binding site [ion binding]; other site 646529007712 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 646529007713 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 646529007714 substrate-cofactor binding pocket; other site 646529007715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529007716 catalytic residue [active] 646529007717 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 646529007718 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 646529007719 NAD binding site [chemical binding]; other site 646529007720 homodimer interface [polypeptide binding]; other site 646529007721 active site 646529007722 putative substrate binding site [chemical binding]; other site 646529007723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529007724 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529007725 putative substrate translocation pore; other site 646529007726 Transcriptional regulator [Transcription]; Region: LysR; COG0583 646529007727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 646529007728 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 646529007729 putative dimerization interface [polypeptide binding]; other site 646529007730 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 646529007731 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 646529007732 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529007733 dimer interface [polypeptide binding]; other site 646529007734 putative CheW interface [polypeptide binding]; other site 646529007735 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529007736 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529007737 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 646529007738 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 646529007739 Penicillinase repressor; Region: Pencillinase_R; pfam03965 646529007740 Transglycosylase; Region: Transgly; pfam00912 646529007741 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 646529007742 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 646529007743 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 646529007744 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 646529007745 Sulfate transporter family; Region: Sulfate_transp; pfam00916 646529007746 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 646529007747 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 646529007748 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 646529007749 substrate binding site [chemical binding]; other site 646529007750 dimer interface [polypeptide binding]; other site 646529007751 ATP binding site [chemical binding]; other site 646529007752 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 646529007753 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 646529007754 ligand binding site [chemical binding]; other site 646529007755 dimerization interface [polypeptide binding]; other site 646529007756 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 646529007757 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 646529007758 TM-ABC transporter signature motif; other site 646529007759 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 646529007760 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 646529007761 Walker A/P-loop; other site 646529007762 ATP binding site [chemical binding]; other site 646529007763 Q-loop/lid; other site 646529007764 ABC transporter signature motif; other site 646529007765 Walker B; other site 646529007766 D-loop; other site 646529007767 H-loop/switch region; other site 646529007768 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 646529007769 D-ribose pyranase; Provisional; Region: PRK11797 646529007770 Transcriptional regulators [Transcription]; Region: PurR; COG1609 646529007771 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 646529007772 DNA binding site [nucleotide binding] 646529007773 domain linker motif; other site 646529007774 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 646529007775 dimerization interface [polypeptide binding]; other site 646529007776 ligand binding site [chemical binding]; other site 646529007777 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 646529007778 VanW like protein; Region: VanW; pfam04294 646529007779 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529007780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529007781 active site 646529007782 phosphorylation site [posttranslational modification] 646529007783 intermolecular recognition site; other site 646529007784 dimerization interface [polypeptide binding]; other site 646529007785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529007786 DNA binding site [nucleotide binding] 646529007787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529007788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529007789 dimerization interface [polypeptide binding]; other site 646529007790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529007791 dimer interface [polypeptide binding]; other site 646529007792 phosphorylation site [posttranslational modification] 646529007793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529007794 ATP binding site [chemical binding]; other site 646529007795 Mg2+ binding site [ion binding]; other site 646529007796 G-X-G motif; other site 646529007797 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 646529007798 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 646529007799 FAD binding domain; Region: FAD_binding_4; pfam01565 646529007800 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529007801 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 646529007802 diiron binding motif [ion binding]; other site 646529007803 Uncharacterized conserved protein [Function unknown]; Region: COG1416 646529007804 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 646529007805 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 646529007806 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 646529007807 substrate binding pocket [chemical binding]; other site 646529007808 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 646529007809 B12 binding site [chemical binding]; other site 646529007810 cobalt ligand [ion binding]; other site 646529007811 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 646529007812 Transcriptional regulator [Transcription]; Region: LysR; COG0583 646529007813 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 646529007814 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 646529007815 dimerization interface [polypeptide binding]; other site 646529007816 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 646529007817 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 646529007818 Potassium binding sites [ion binding]; other site 646529007819 Cesium cation binding sites [ion binding]; other site 646529007820 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 646529007821 CmuC_like. Proteins similar to the putative corrinoid methyltransferase CmuC. Its function has been inferred from sequence similarity to the methyltransferases CmuA and MtaA. Mutants of Methylobacterium sp. disrupted in cmuC and purU appear deficient in...; Region: CmuC_like; cd03309 646529007822 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 646529007823 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 646529007824 B12 binding site [chemical binding]; other site 646529007825 cobalt ligand [ion binding]; other site 646529007826 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 646529007827 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 646529007828 substrate binding pocket [chemical binding]; other site 646529007829 dimer interface [polypeptide binding]; other site 646529007830 inhibitor binding site; inhibition site 646529007831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529007832 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529007833 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529007834 amino acid transporter; Region: 2A0306; TIGR00909 646529007835 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 646529007836 Flagellin N-methylase; Region: FliB; pfam03692 646529007837 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 646529007838 NlpC/P60 family; Region: NLPC_P60; pfam00877 646529007839 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 646529007840 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529007841 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529007842 metal binding site [ion binding]; metal-binding site 646529007843 active site 646529007844 I-site; other site 646529007845 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 646529007846 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 646529007847 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 646529007848 Predicted membrane protein [Function unknown]; Region: COG2246 646529007849 GtrA-like protein; Region: GtrA; pfam04138 646529007850 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 646529007851 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 646529007852 NAD binding site [chemical binding]; other site 646529007853 substrate binding site [chemical binding]; other site 646529007854 active site 646529007855 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 646529007856 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 646529007857 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 646529007858 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 646529007859 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 646529007860 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 646529007861 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 646529007862 dimer interface [polypeptide binding]; other site 646529007863 active site 646529007864 metal binding site [ion binding]; metal-binding site 646529007865 glutathione binding site [chemical binding]; other site 646529007866 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 646529007867 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 646529007868 intersubunit interface [polypeptide binding]; other site 646529007869 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 646529007870 B12 binding site [chemical binding]; other site 646529007871 cobalt ligand [ion binding]; other site 646529007872 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 646529007873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529007874 ArgK protein; Region: ArgK; pfam03308 646529007875 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 646529007876 Walker A; other site 646529007877 Walker A/P-loop; other site 646529007878 ATP binding site [chemical binding]; other site 646529007879 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 646529007880 G4 box; other site 646529007881 G5 box; other site 646529007882 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 646529007883 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 646529007884 Walker A motif; other site 646529007885 homodimer interface [polypeptide binding]; other site 646529007886 ATP binding site [chemical binding]; other site 646529007887 hydroxycobalamin binding site [chemical binding]; other site 646529007888 Walker B motif; other site 646529007889 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529007890 dimer interface [polypeptide binding]; other site 646529007891 putative CheW interface [polypeptide binding]; other site 646529007892 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 646529007893 MFS/sugar transport protein; Region: MFS_2; pfam13347 646529007894 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 646529007895 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 646529007896 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 646529007897 B12 binding site [chemical binding]; other site 646529007898 cobalt ligand [ion binding]; other site 646529007899 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 646529007900 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 646529007901 substrate binding pocket [chemical binding]; other site 646529007902 dimer interface [polypeptide binding]; other site 646529007903 inhibitor binding site; inhibition site 646529007904 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529007905 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 646529007906 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529007907 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 646529007908 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 646529007909 catalytic loop [active] 646529007910 iron binding site [ion binding]; other site 646529007911 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 646529007912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529007913 DNA-binding site [nucleotide binding]; DNA binding site 646529007914 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 646529007915 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 646529007916 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 646529007917 B12 binding site [chemical binding]; other site 646529007918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529007919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529007920 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 646529007921 putative active site [active] 646529007922 heme pocket [chemical binding]; other site 646529007923 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529007924 putative active site [active] 646529007925 heme pocket [chemical binding]; other site 646529007926 PAS domain; Region: PAS; smart00091 646529007927 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 646529007928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529007929 dimer interface [polypeptide binding]; other site 646529007930 phosphorylation site [posttranslational modification] 646529007931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529007932 ATP binding site [chemical binding]; other site 646529007933 Mg2+ binding site [ion binding]; other site 646529007934 G-X-G motif; other site 646529007935 Methyltransferase domain; Region: Methyltransf_23; pfam13489 646529007936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529007937 S-adenosylmethionine binding site [chemical binding]; other site 646529007938 Predicted membrane protein [Function unknown]; Region: COG3462 646529007939 Short C-terminal domain; Region: SHOCT; pfam09851 646529007940 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 646529007941 Protein export membrane protein; Region: SecD_SecF; cl14618 646529007942 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 646529007943 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 646529007944 HlyD family secretion protein; Region: HlyD_3; pfam13437 646529007945 putative membrane fusion protein; Region: TIGR02828 646529007946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529007947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529007948 benzoate transporter; Region: benE; TIGR00843 646529007949 xanthine permease; Region: pbuX; TIGR03173 646529007950 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 646529007951 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 646529007952 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529007953 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529007954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529007955 active site 646529007956 phosphorylation site [posttranslational modification] 646529007957 intermolecular recognition site; other site 646529007958 dimerization interface [polypeptide binding]; other site 646529007959 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529007960 DNA binding site [nucleotide binding] 646529007961 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 646529007962 NlpC/P60 family; Region: NLPC_P60; pfam00877 646529007963 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529007964 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529007965 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529007966 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 646529007967 Predicted integral membrane protein [Function unknown]; Region: COG5542 646529007968 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 646529007969 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 646529007970 active site 646529007971 tetramer interface; other site 646529007972 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529007973 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529007974 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529007975 Predicted membrane protein [Function unknown]; Region: COG2246 646529007976 GtrA-like protein; Region: GtrA; pfam04138 646529007977 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 646529007978 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 646529007979 Ligand binding site; other site 646529007980 Putative Catalytic site; other site 646529007981 DXD motif; other site 646529007982 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 646529007983 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 646529007984 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 646529007985 NodB motif; other site 646529007986 putative active site [active] 646529007987 putative catalytic site [active] 646529007988 Zn binding site [ion binding]; other site 646529007989 Spore germination protein; Region: Spore_permease; cl17796 646529007990 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 646529007991 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529007992 Zn2+ binding site [ion binding]; other site 646529007993 Mg2+ binding site [ion binding]; other site 646529007994 GEMM cis-regulatory element 646529007995 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 646529007996 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 646529007997 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 646529007998 FOG: CBS domain [General function prediction only]; Region: COG0517 646529007999 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 646529008000 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 646529008001 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 646529008002 Peptidase family M28; Region: Peptidase_M28; pfam04389 646529008003 metal binding site [ion binding]; metal-binding site 646529008004 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 646529008005 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 646529008006 putative substrate-binding site; other site 646529008007 nickel binding site [ion binding]; other site 646529008008 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 646529008009 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529008010 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 646529008011 Coenzyme A binding pocket [chemical binding]; other site 646529008012 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 646529008013 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 646529008014 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 646529008015 B12 binding site [chemical binding]; other site 646529008016 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529008017 FeS/SAM binding site; other site 646529008018 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 646529008019 Propionate catabolism activator; Region: PrpR_N; pfam06506 646529008020 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529008021 putative CheW interface [polypeptide binding]; other site 646529008022 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 646529008023 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 646529008024 Spore germination protein; Region: Spore_permease; cl17796 646529008025 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 646529008026 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 646529008027 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 646529008028 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 646529008029 Glyco_18 domain; Region: Glyco_18; smart00636 646529008030 active site 646529008031 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 646529008032 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 646529008033 NodB motif; other site 646529008034 active site 646529008035 catalytic site [active] 646529008036 metal binding site [ion binding]; metal-binding site 646529008037 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 646529008038 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 646529008039 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 646529008040 active site 646529008041 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 646529008042 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 646529008043 active site 646529008044 metal binding site [ion binding]; metal-binding site 646529008045 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 646529008046 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 646529008047 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 646529008048 active site 646529008049 metal binding site [ion binding]; metal-binding site 646529008050 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 646529008051 Bacterial SH3 domain; Region: SH3_3; pfam08239 646529008052 Bacterial SH3 domain; Region: SH3_3; cl17532 646529008053 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 646529008054 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 646529008055 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 646529008056 putative active site [active] 646529008057 putative metal binding site [ion binding]; other site 646529008058 hypothetical protein; Provisional; Region: PRK04164 646529008059 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 646529008060 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 646529008061 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 646529008062 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 646529008063 Peptidase family M23; Region: Peptidase_M23; pfam01551 646529008064 LexA repressor; Validated; Region: PRK00215 646529008065 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 646529008066 putative DNA binding site [nucleotide binding]; other site 646529008067 putative Zn2+ binding site [ion binding]; other site 646529008068 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 646529008069 Catalytic site [active] 646529008070 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 646529008071 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 646529008072 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 646529008073 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 646529008074 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 646529008075 Catalytic site [active] 646529008076 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 646529008077 Aluminium resistance protein; Region: Alum_res; pfam06838 646529008078 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 646529008079 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 646529008080 HflX GTPase family; Region: HflX; cd01878 646529008081 G1 box; other site 646529008082 GTP/Mg2+ binding site [chemical binding]; other site 646529008083 Switch I region; other site 646529008084 G2 box; other site 646529008085 G3 box; other site 646529008086 Switch II region; other site 646529008087 G4 box; other site 646529008088 G5 box; other site 646529008089 stage V sporulation protein K; Region: spore_V_K; TIGR02881 646529008090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529008091 Walker A motif; other site 646529008092 ATP binding site [chemical binding]; other site 646529008093 Walker B motif; other site 646529008094 arginine finger; other site 646529008095 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 646529008096 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 646529008097 G1 box; other site 646529008098 putative GEF interaction site [polypeptide binding]; other site 646529008099 GTP/Mg2+ binding site [chemical binding]; other site 646529008100 Switch I region; other site 646529008101 G2 box; other site 646529008102 G3 box; other site 646529008103 Switch II region; other site 646529008104 G4 box; other site 646529008105 G5 box; other site 646529008106 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 646529008107 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 646529008108 bacterial Hfq-like; Region: Hfq; cd01716 646529008109 hexamer interface [polypeptide binding]; other site 646529008110 Sm1 motif; other site 646529008111 RNA binding site [nucleotide binding]; other site 646529008112 Sm2 motif; other site 646529008113 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 646529008114 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 646529008115 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 646529008116 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 646529008117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529008118 ATP binding site [chemical binding]; other site 646529008119 Mg2+ binding site [ion binding]; other site 646529008120 G-X-G motif; other site 646529008121 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 646529008122 ATP binding site [chemical binding]; other site 646529008123 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 646529008124 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 646529008125 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 646529008126 active site 646529008127 Zn binding site [ion binding]; other site 646529008128 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 646529008129 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 646529008130 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 646529008131 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 646529008132 MutS domain I; Region: MutS_I; pfam01624 646529008133 MutS domain II; Region: MutS_II; pfam05188 646529008134 MutS domain III; Region: MutS_III; pfam05192 646529008135 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 646529008136 Walker A/P-loop; other site 646529008137 ATP binding site [chemical binding]; other site 646529008138 Q-loop/lid; other site 646529008139 ABC transporter signature motif; other site 646529008140 Walker B; other site 646529008141 D-loop; other site 646529008142 H-loop/switch region; other site 646529008143 Protein of unknown function (DUF964); Region: DUF964; pfam06133 646529008144 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 646529008145 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 646529008146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529008147 FeS/SAM binding site; other site 646529008148 TRAM domain; Region: TRAM; pfam01938 646529008149 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 646529008150 Domain of unknown function DUF20; Region: UPF0118; pfam01594 646529008151 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 646529008152 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 646529008153 EDD domain protein, DegV family; Region: DegV; TIGR00762 646529008154 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 646529008155 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 646529008156 active site 646529008157 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 646529008158 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 646529008159 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 646529008160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529008161 DNA-binding site [nucleotide binding]; DNA binding site 646529008162 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 646529008163 pyruvate kinase; Provisional; Region: PRK06354 646529008164 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 646529008165 domain interfaces; other site 646529008166 active site 646529008167 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 646529008168 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 646529008169 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 646529008170 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 646529008171 putative acyltransferase; Provisional; Region: PRK05790 646529008172 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 646529008173 dimer interface [polypeptide binding]; other site 646529008174 active site 646529008175 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 646529008176 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 646529008177 FAD binding site [chemical binding]; other site 646529008178 homotetramer interface [polypeptide binding]; other site 646529008179 substrate binding pocket [chemical binding]; other site 646529008180 catalytic base [active] 646529008181 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 646529008182 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 646529008183 substrate binding site [chemical binding]; other site 646529008184 oxyanion hole (OAH) forming residues; other site 646529008185 trimer interface [polypeptide binding]; other site 646529008186 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 646529008187 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 646529008188 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 646529008189 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529008190 PAS domain; Region: PAS; smart00091 646529008191 putative active site [active] 646529008192 heme pocket [chemical binding]; other site 646529008193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529008194 putative active site [active] 646529008195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529008196 Walker A motif; other site 646529008197 ATP binding site [chemical binding]; other site 646529008198 Walker B motif; other site 646529008199 arginine finger; other site 646529008200 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529008201 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 646529008202 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 646529008203 ligand binding site [chemical binding]; other site 646529008204 flexible hinge region; other site 646529008205 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 646529008206 putative switch regulator; other site 646529008207 non-specific DNA interactions [nucleotide binding]; other site 646529008208 DNA binding site [nucleotide binding] 646529008209 sequence specific DNA binding site [nucleotide binding]; other site 646529008210 putative cAMP binding site [chemical binding]; other site 646529008211 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529008212 4Fe-4S binding domain; Region: Fer4_6; pfam12837 646529008213 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 646529008214 PhoU domain; Region: PhoU; pfam01895 646529008215 PhoU domain; Region: PhoU; pfam01895 646529008216 FOG: CBS domain [General function prediction only]; Region: COG0517 646529008217 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 646529008218 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529008219 Cysteine-rich domain; Region: CCG; pfam02754 646529008220 Cysteine-rich domain; Region: CCG; pfam02754 646529008221 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 646529008222 Predicted flavoprotein [General function prediction only]; Region: COG0431 646529008223 dipeptidase PepV; Reviewed; Region: PRK07318 646529008224 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 646529008225 active site 646529008226 metal binding site [ion binding]; metal-binding site 646529008227 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 646529008228 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 646529008229 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 646529008230 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 646529008231 Rhomboid family; Region: Rhomboid; pfam01694 646529008232 Protein of unknown function DUF111; Region: DUF111; cl03398 646529008233 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 646529008234 AIR carboxylase; Region: AIRC; smart01001 646529008235 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 646529008236 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 646529008237 Ligand Binding Site [chemical binding]; other site 646529008238 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 646529008239 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 646529008240 putative oxidoreductase FixC; Provisional; Region: PRK10157 646529008241 Ferredoxin [Energy production and conversion]; Region: COG1146 646529008242 4Fe-4S binding domain; Region: Fer4; pfam00037 646529008243 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 646529008244 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 646529008245 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 646529008246 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 646529008247 Ligand binding site [chemical binding]; other site 646529008248 Electron transfer flavoprotein domain; Region: ETF; pfam01012 646529008249 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 646529008250 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 646529008251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 646529008252 Uncharacterized conserved protein [Function unknown]; Region: COG1615 646529008253 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 646529008254 Predicted periplasmic protein [Function unknown]; Region: COG3698 646529008255 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 646529008256 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 646529008257 Response regulator receiver domain; Region: Response_reg; pfam00072 646529008258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529008259 active site 646529008260 phosphorylation site [posttranslational modification] 646529008261 intermolecular recognition site; other site 646529008262 dimerization interface [polypeptide binding]; other site 646529008263 ANTAR domain; Region: ANTAR; pfam03861 646529008264 putative hydrolase; Validated; Region: PRK09248 646529008265 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 646529008266 active site 646529008267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529008268 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 646529008269 Walker A motif; other site 646529008270 ATP binding site [chemical binding]; other site 646529008271 Walker B motif; other site 646529008272 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 646529008273 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 646529008274 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529008275 Zn2+ binding site [ion binding]; other site 646529008276 Mg2+ binding site [ion binding]; other site 646529008277 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 646529008278 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 646529008279 Beta-Casp domain; Region: Beta-Casp; smart01027 646529008280 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 646529008281 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 646529008282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529008283 active site 646529008284 phosphorylation site [posttranslational modification] 646529008285 intermolecular recognition site; other site 646529008286 dimerization interface [polypeptide binding]; other site 646529008287 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 646529008288 DNA binding residues [nucleotide binding] 646529008289 dimerization interface [polypeptide binding]; other site 646529008290 Sensor protein DegS; Region: DegS; pfam05384 646529008291 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 646529008292 Histidine kinase; Region: HisKA_3; pfam07730 646529008293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529008294 ATP binding site [chemical binding]; other site 646529008295 Mg2+ binding site [ion binding]; other site 646529008296 G-X-G motif; other site 646529008297 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 646529008298 substrate binding pocket [chemical binding]; other site 646529008299 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 646529008300 dimer interface [polypeptide binding]; other site 646529008301 inhibitor binding site; inhibition site 646529008302 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 646529008303 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 646529008304 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 646529008305 P-loop; other site 646529008306 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 646529008307 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 646529008308 catalytic loop [active] 646529008309 iron binding site [ion binding]; other site 646529008310 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 646529008311 Putative Fe-S cluster; Region: FeS; pfam04060 646529008312 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 646529008313 Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH)...; Region: ACS_2; cd01917 646529008314 CODH interaction site; other site 646529008315 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 646529008316 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 646529008317 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 646529008318 ACS interaction site; other site 646529008319 CODH interaction site; other site 646529008320 cubane metal cluster (B-cluster) [ion binding]; other site 646529008321 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 646529008322 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 646529008323 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 646529008324 P-loop; other site 646529008325 EDD domain protein, DegV family; Region: DegV; TIGR00762 646529008326 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 646529008327 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 646529008328 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 646529008329 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 646529008330 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 646529008331 catalytic motif [active] 646529008332 Zn binding site [ion binding]; other site 646529008333 RibD C-terminal domain; Region: RibD_C; cl17279 646529008334 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 646529008335 Lumazine binding domain; Region: Lum_binding; pfam00677 646529008336 Lumazine binding domain; Region: Lum_binding; pfam00677 646529008337 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 646529008338 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 646529008339 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 646529008340 dimerization interface [polypeptide binding]; other site 646529008341 active site 646529008342 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 646529008343 homopentamer interface [polypeptide binding]; other site 646529008344 active site 646529008345 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 646529008346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529008347 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 646529008348 Coat F domain; Region: Coat_F; cl17715 646529008349 DivIVA protein; Region: DivIVA; pfam05103 646529008350 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 646529008351 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 646529008352 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 646529008353 Clp amino terminal domain; Region: Clp_N; pfam02861 646529008354 Clp amino terminal domain; Region: Clp_N; pfam02861 646529008355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529008356 Walker A motif; other site 646529008357 ATP binding site [chemical binding]; other site 646529008358 Walker B motif; other site 646529008359 arginine finger; other site 646529008360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529008361 Walker A motif; other site 646529008362 ATP binding site [chemical binding]; other site 646529008363 Walker B motif; other site 646529008364 arginine finger; other site 646529008365 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 646529008366 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 646529008367 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 646529008368 HSP70 interaction site [polypeptide binding]; other site 646529008369 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 646529008370 substrate binding site [polypeptide binding]; other site 646529008371 dimer interface [polypeptide binding]; other site 646529008372 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 646529008373 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 646529008374 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 646529008375 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 646529008376 active site 646529008377 substrate binding site [chemical binding]; other site 646529008378 metal binding site [ion binding]; metal-binding site 646529008379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529008380 Coenzyme A binding pocket [chemical binding]; other site 646529008381 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 646529008382 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 646529008383 active site 646529008384 metal binding site [ion binding]; metal-binding site 646529008385 Probable zinc-binding domain; Region: zf-trcl; pfam13451 646529008386 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 646529008387 Predicted amidohydrolase [General function prediction only]; Region: COG0388 646529008388 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 646529008389 active site 646529008390 catalytic triad [active] 646529008391 dimer interface [polypeptide binding]; other site 646529008392 Transcriptional regulator [Transcription]; Region: LysR; COG0583 646529008393 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 646529008394 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 646529008395 putative dimerization interface [polypeptide binding]; other site 646529008396 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 646529008397 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 646529008398 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 646529008399 catalytic triad [active] 646529008400 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 646529008401 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 646529008402 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 646529008403 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 646529008404 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529008405 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529008406 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529008407 Cysteine-rich domain; Region: CCG; pfam02754 646529008408 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 646529008409 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 646529008410 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 646529008411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 646529008412 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 646529008413 peptidase T; Region: peptidase-T; TIGR01882 646529008414 metal binding site [ion binding]; metal-binding site 646529008415 dimer interface [polypeptide binding]; other site 646529008416 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 646529008417 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 646529008418 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 646529008419 catalytic residue [active] 646529008420 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 646529008421 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 646529008422 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 646529008423 RNA/DNA hybrid binding site [nucleotide binding]; other site 646529008424 active site 646529008425 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 646529008426 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 646529008427 Methyltransferase domain; Region: Methyltransf_31; pfam13847 646529008428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529008429 S-adenosylmethionine binding site [chemical binding]; other site 646529008430 Putative glucoamylase; Region: Glycoamylase; pfam10091 646529008431 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 646529008432 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 646529008433 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 646529008434 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 646529008435 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 646529008436 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 646529008437 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 646529008438 BON domain; Region: BON; pfam04972 646529008439 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 646529008440 BON domain; Region: BON; pfam04972 646529008441 BON domain; Region: BON; pfam04972 646529008442 BON domain; Region: BON; pfam04972 646529008443 Ion channel; Region: Ion_trans_2; pfam07885 646529008444 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 646529008445 TrkA-N domain; Region: TrkA_N; pfam02254 646529008446 TrkA-C domain; Region: TrkA_C; pfam02080 646529008447 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 646529008448 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 646529008449 active site 646529008450 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 646529008451 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 646529008452 non-specific DNA binding site [nucleotide binding]; other site 646529008453 salt bridge; other site 646529008454 sequence-specific DNA binding site [nucleotide binding]; other site 646529008455 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 646529008456 YcfA-like protein; Region: YcfA; pfam07927 646529008457 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 646529008458 membrane protein P6; Region: PHA01399 646529008459 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 646529008460 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 646529008461 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529008462 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 646529008463 DNA binding residues [nucleotide binding] 646529008464 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 646529008465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529008466 Walker A motif; other site 646529008467 ATP binding site [chemical binding]; other site 646529008468 Walker B motif; other site 646529008469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 646529008470 DNA-binding site [nucleotide binding]; DNA binding site 646529008471 Helix-turn-helix domain; Region: HTH_17; cl17695 646529008472 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 646529008473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529008474 salt bridge; other site 646529008475 non-specific DNA binding site [nucleotide binding]; other site 646529008476 sequence-specific DNA binding site [nucleotide binding]; other site 646529008477 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 646529008478 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529008479 sequence-specific DNA binding site [nucleotide binding]; other site 646529008480 salt bridge; other site 646529008481 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529008482 salt bridge; other site 646529008483 non-specific DNA binding site [nucleotide binding]; other site 646529008484 sequence-specific DNA binding site [nucleotide binding]; other site 646529008485 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 646529008486 Int/Topo IB signature motif; other site 646529008487 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 646529008488 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 646529008489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529008490 DNA-binding site [nucleotide binding]; DNA binding site 646529008491 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 646529008492 PLD-like domain; Region: PLDc_2; pfam13091 646529008493 putative active site [active] 646529008494 catalytic site [active] 646529008495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529008496 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529008497 putative substrate translocation pore; other site 646529008498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529008499 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 646529008500 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529008501 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 646529008502 elongation factor G; Reviewed; Region: PRK12740 646529008503 G1 box; other site 646529008504 putative GEF interaction site [polypeptide binding]; other site 646529008505 GTP/Mg2+ binding site [chemical binding]; other site 646529008506 Switch I region; other site 646529008507 G2 box; other site 646529008508 G3 box; other site 646529008509 Switch II region; other site 646529008510 G4 box; other site 646529008511 G5 box; other site 646529008512 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 646529008513 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 646529008514 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 646529008515 isoaspartyl dipeptidase; Provisional; Region: PRK10657 646529008516 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 646529008517 active site 646529008518 stage V sporulation protein B; Region: spore_V_B; TIGR02900 646529008519 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 646529008520 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 646529008521 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 646529008522 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 646529008523 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 646529008524 homodecamer interface [polypeptide binding]; other site 646529008525 GTP cyclohydrolase I; Provisional; Region: PLN03044 646529008526 active site 646529008527 putative catalytic site residues [active] 646529008528 zinc binding site [ion binding]; other site 646529008529 GTP-CH-I/GFRP interaction surface; other site 646529008530 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 646529008531 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529008532 FeS/SAM binding site; other site 646529008533 Domain of unknown function (DUF366); Region: DUF366; pfam04017 646529008534 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 646529008535 Ligand Binding Site [chemical binding]; other site 646529008536 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 646529008537 active site 646529008538 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 646529008539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529008540 TPR motif; other site 646529008541 binding surface 646529008542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529008543 TPR motif; other site 646529008544 binding surface 646529008545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529008546 binding surface 646529008547 TPR motif; other site 646529008548 TPR repeat; Region: TPR_11; pfam13414 646529008549 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 646529008550 metal binding site 2 [ion binding]; metal-binding site 646529008551 putative DNA binding helix; other site 646529008552 metal binding site 1 [ion binding]; metal-binding site 646529008553 dimer interface [polypeptide binding]; other site 646529008554 structural Zn2+ binding site [ion binding]; other site 646529008555 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 646529008556 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 646529008557 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 646529008558 putative RNA binding site [nucleotide binding]; other site 646529008559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529008560 S-adenosylmethionine binding site [chemical binding]; other site 646529008561 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 646529008562 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 646529008563 Peptidase family M28; Region: Peptidase_M28; pfam04389 646529008564 metal binding site [ion binding]; metal-binding site 646529008565 PLD-like domain; Region: PLDc_2; pfam13091 646529008566 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 646529008567 putative active site [active] 646529008568 catalytic site [active] 646529008569 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 646529008570 PLD-like domain; Region: PLDc_2; pfam13091 646529008571 putative active site [active] 646529008572 catalytic site [active] 646529008573 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 646529008574 catalytic core [active] 646529008575 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 646529008576 oligomerization interface [polypeptide binding]; other site 646529008577 active site 646529008578 metal binding site [ion binding]; metal-binding site 646529008579 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 646529008580 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 646529008581 cell division protein FtsA; Region: ftsA; TIGR01174 646529008582 Cell division protein FtsA; Region: FtsA; smart00842 646529008583 Cell division protein FtsA; Region: FtsA; pfam14450 646529008584 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 646529008585 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 646529008586 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 646529008587 active site 646529008588 dimer interface [polypeptide binding]; other site 646529008589 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 646529008590 dimer interface [polypeptide binding]; other site 646529008591 active site 646529008592 6-phosphofructokinase; Provisional; Region: PRK03202 646529008593 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 646529008594 active site 646529008595 ADP/pyrophosphate binding site [chemical binding]; other site 646529008596 dimerization interface [polypeptide binding]; other site 646529008597 allosteric effector site; other site 646529008598 fructose-1,6-bisphosphate binding site; other site 646529008599 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529008600 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529008601 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529008602 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 646529008603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 646529008604 Walker A motif; other site 646529008605 ATP binding site [chemical binding]; other site 646529008606 Walker B motif; other site 646529008607 arginine finger; other site 646529008608 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 646529008609 DnaA box-binding interface [nucleotide binding]; other site 646529008610 Transcriptional regulator [Transcription]; Region: LysR; COG0583 646529008611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 646529008612 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 646529008613 putative dimerization interface [polypeptide binding]; other site 646529008614 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 646529008615 active site 646529008616 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 646529008617 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 646529008618 intersubunit interface [polypeptide binding]; other site 646529008619 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 646529008620 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 646529008621 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 646529008622 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 646529008623 ABC-ATPase subunit interface; other site 646529008624 dimer interface [polypeptide binding]; other site 646529008625 putative PBP binding regions; other site 646529008626 ferric uptake regulator; Provisional; Region: fur; PRK09462 646529008627 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 646529008628 metal binding site 2 [ion binding]; metal-binding site 646529008629 putative DNA binding helix; other site 646529008630 metal binding site 1 [ion binding]; metal-binding site 646529008631 dimer interface [polypeptide binding]; other site 646529008632 structural Zn2+ binding site [ion binding]; other site 646529008633 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 646529008634 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 646529008635 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 646529008636 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 646529008637 SpoVR like protein; Region: SpoVR; pfam04293 646529008638 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 646529008639 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 646529008640 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 646529008641 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 646529008642 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 646529008643 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 646529008644 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 646529008645 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 646529008646 homodimer interface [polypeptide binding]; other site 646529008647 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 646529008648 Walker A motif; other site 646529008649 ATP binding site [chemical binding]; other site 646529008650 hydroxycobalamin binding site [chemical binding]; other site 646529008651 Walker B motif; other site 646529008652 Tetratricopeptide repeat; Region: TPR_12; pfam13424 646529008653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529008654 TPR motif; other site 646529008655 binding surface 646529008656 Tetratricopeptide repeat; Region: TPR_12; pfam13424 646529008657 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 646529008658 Uncharacterized conserved protein [Function unknown]; Region: COG1284 646529008659 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 646529008660 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 646529008661 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 646529008662 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 646529008663 thymidylate kinase; Provisional; Region: PRK13975; cl17243 646529008664 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 646529008665 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 646529008666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529008667 active site 646529008668 phosphorylation site [posttranslational modification] 646529008669 intermolecular recognition site; other site 646529008670 dimerization interface [polypeptide binding]; other site 646529008671 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 646529008672 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 646529008673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529008674 Coenzyme A binding pocket [chemical binding]; other site 646529008675 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 646529008676 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 646529008677 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 646529008678 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 646529008679 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 646529008680 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 646529008681 peptide binding site [polypeptide binding]; other site 646529008682 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 646529008683 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 646529008684 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 646529008685 active site 646529008686 catalytic site [active] 646529008687 substrate binding site [chemical binding]; other site 646529008688 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 646529008689 DEAD/DEAH box helicase; Region: DEAD; pfam00270 646529008690 ATP binding site [chemical binding]; other site 646529008691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529008692 nucleotide binding region [chemical binding]; other site 646529008693 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 646529008694 Ferritin-like domain; Region: Ferritin; pfam00210 646529008695 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 646529008696 dinuclear metal binding motif [ion binding]; other site 646529008697 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 646529008698 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 646529008699 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 646529008700 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 646529008701 active site 646529008702 metal binding site [ion binding]; metal-binding site 646529008703 homotetramer interface [polypeptide binding]; other site 646529008704 Protein of unknown function, DUF606; Region: DUF606; pfam04657 646529008705 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 646529008706 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 646529008707 GIY-YIG motif/motif A; other site 646529008708 active site 646529008709 catalytic site [active] 646529008710 putative DNA binding site [nucleotide binding]; other site 646529008711 metal binding site [ion binding]; metal-binding site 646529008712 UvrB/uvrC motif; Region: UVR; pfam02151 646529008713 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 646529008714 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 646529008715 NlpC/P60 family; Region: NLPC_P60; pfam00877 646529008716 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 646529008717 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 646529008718 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 646529008719 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 646529008720 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529008721 Zn2+ binding site [ion binding]; other site 646529008722 Mg2+ binding site [ion binding]; other site 646529008723 TPR repeat; Region: TPR_11; pfam13414 646529008724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529008725 binding surface 646529008726 TPR motif; other site 646529008727 TPR repeat; Region: TPR_11; pfam13414 646529008728 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 646529008729 oligoendopeptidase F; Region: pepF; TIGR00181 646529008730 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 646529008731 active site 646529008732 Zn binding site [ion binding]; other site 646529008733 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 646529008734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529008735 DNA-binding site [nucleotide binding]; DNA binding site 646529008736 UTRA domain; Region: UTRA; pfam07702 646529008737 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 646529008738 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 646529008739 TM-ABC transporter signature motif; other site 646529008740 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 646529008741 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 646529008742 TM-ABC transporter signature motif; other site 646529008743 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 646529008744 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 646529008745 Walker A/P-loop; other site 646529008746 ATP binding site [chemical binding]; other site 646529008747 Q-loop/lid; other site 646529008748 ABC transporter signature motif; other site 646529008749 Walker B; other site 646529008750 D-loop; other site 646529008751 H-loop/switch region; other site 646529008752 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 646529008753 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 646529008754 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 646529008755 ligand binding site [chemical binding]; other site 646529008756 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 646529008757 putative active site; other site 646529008758 putative metal binding residues [ion binding]; other site 646529008759 signature motif; other site 646529008760 putative triphosphate binding site [ion binding]; other site 646529008761 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 646529008762 Prephenate dehydratase; Region: PDT; pfam00800 646529008763 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 646529008764 putative L-Phe binding site [chemical binding]; other site 646529008765 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 646529008766 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 646529008767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529008768 catalytic residue [active] 646529008769 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 646529008770 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 646529008771 active site 646529008772 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 646529008773 active site 646529008774 dimer interfaces [polypeptide binding]; other site 646529008775 catalytic residues [active] 646529008776 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 646529008777 GIY-YIG motif/motif A; other site 646529008778 putative active site [active] 646529008779 putative metal binding site [ion binding]; other site 646529008780 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 646529008781 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 646529008782 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 646529008783 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 646529008784 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 646529008785 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 646529008786 minor groove reading motif; other site 646529008787 helix-hairpin-helix signature motif; other site 646529008788 substrate binding pocket [chemical binding]; other site 646529008789 active site 646529008790 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 646529008791 hypothetical protein; Provisional; Region: PRK10621 646529008792 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 646529008793 VanW like protein; Region: VanW; pfam04294 646529008794 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 646529008795 PRC-barrel domain; Region: PRC; pfam05239 646529008796 Uncharacterized conserved protein [Function unknown]; Region: COG1739 646529008797 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 646529008798 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 646529008799 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 646529008800 subunit interaction site [polypeptide binding]; other site 646529008801 PHB binding site; other site 646529008802 CoenzymeA binding site [chemical binding]; other site 646529008803 FOG: CBS domain [General function prediction only]; Region: COG0517 646529008804 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 646529008805 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 646529008806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529008807 S-adenosylmethionine binding site [chemical binding]; other site 646529008808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529008809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529008810 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 646529008811 FeoC like transcriptional regulator; Region: FeoC; cl17677 646529008812 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 646529008813 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 646529008814 G1 box; other site 646529008815 GTP/Mg2+ binding site [chemical binding]; other site 646529008816 Switch I region; other site 646529008817 G2 box; other site 646529008818 G3 box; other site 646529008819 Switch II region; other site 646529008820 G4 box; other site 646529008821 G5 box; other site 646529008822 Nucleoside recognition; Region: Gate; pfam07670 646529008823 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 646529008824 Nucleoside recognition; Region: Gate; pfam07670 646529008825 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 646529008826 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 646529008827 active site 646529008828 homotetramer interface [polypeptide binding]; other site 646529008829 homodimer interface [polypeptide binding]; other site 646529008830 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 646529008831 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 646529008832 active site 646529008833 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 646529008834 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 646529008835 ligand binding site [chemical binding]; other site 646529008836 flexible hinge region; other site 646529008837 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 646529008838 putative switch regulator; other site 646529008839 non-specific DNA interactions [nucleotide binding]; other site 646529008840 DNA binding site [nucleotide binding] 646529008841 sequence specific DNA binding site [nucleotide binding]; other site 646529008842 putative cAMP binding site [chemical binding]; other site 646529008843 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 646529008844 ATP binding site [chemical binding]; other site 646529008845 putative Mg++ binding site [ion binding]; other site 646529008846 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529008847 nucleotide binding region [chemical binding]; other site 646529008848 ATP-binding site [chemical binding]; other site 646529008849 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 646529008850 Rubredoxin [Energy production and conversion]; Region: COG1773 646529008851 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 646529008852 iron binding site [ion binding]; other site 646529008853 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 646529008854 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 646529008855 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529008856 Cysteine-rich domain; Region: CCG; pfam02754 646529008857 Cysteine-rich domain; Region: CCG; pfam02754 646529008858 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 646529008859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529008860 D-galactonate transporter; Region: 2A0114; TIGR00893 646529008861 putative substrate translocation pore; other site 646529008862 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 646529008863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529008864 active site 646529008865 phosphorylation site [posttranslational modification] 646529008866 intermolecular recognition site; other site 646529008867 dimerization interface [polypeptide binding]; other site 646529008868 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 646529008869 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529008870 putative active site [active] 646529008871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529008872 ATP binding site [chemical binding]; other site 646529008873 Mg2+ binding site [ion binding]; other site 646529008874 G-X-G motif; other site 646529008875 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 646529008876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529008877 Coenzyme A binding pocket [chemical binding]; other site 646529008878 PAS domain; Region: PAS_9; pfam13426 646529008879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529008880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529008881 dimer interface [polypeptide binding]; other site 646529008882 phosphorylation site [posttranslational modification] 646529008883 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529008884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529008885 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529008886 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 646529008887 homodimer interface [polypeptide binding]; other site 646529008888 homotetramer interface [polypeptide binding]; other site 646529008889 active site pocket [active] 646529008890 cleavage site 646529008891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529008892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529008893 glycerate kinase; Region: TIGR00045 646529008894 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 646529008895 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 646529008896 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 646529008897 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 646529008898 active site 646529008899 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 646529008900 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 646529008901 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 646529008902 active site 646529008903 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 646529008904 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 646529008905 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 646529008906 active site 646529008907 dimer interface [polypeptide binding]; other site 646529008908 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529008909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529008910 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529008911 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 646529008912 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 646529008913 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 646529008914 putative active site [active] 646529008915 metal binding site [ion binding]; metal-binding site 646529008916 homodimer binding site [polypeptide binding]; other site 646529008917 phosphodiesterase; Provisional; Region: PRK12704 646529008918 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529008919 Zn2+ binding site [ion binding]; other site 646529008920 Mg2+ binding site [ion binding]; other site 646529008921 recombination regulator RecX; Reviewed; Region: recX; PRK00117 646529008922 recombinase A; Provisional; Region: recA; PRK09354 646529008923 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 646529008924 hexamer interface [polypeptide binding]; other site 646529008925 Walker A motif; other site 646529008926 ATP binding site [chemical binding]; other site 646529008927 Walker B motif; other site 646529008928 helicase 45; Provisional; Region: PTZ00424 646529008929 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 646529008930 ATP binding site [chemical binding]; other site 646529008931 Mg++ binding site [ion binding]; other site 646529008932 motif III; other site 646529008933 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529008934 nucleotide binding region [chemical binding]; other site 646529008935 ATP-binding site [chemical binding]; other site 646529008936 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 646529008937 RNA binding site [nucleotide binding]; other site 646529008938 competence damage-inducible protein A; Provisional; Region: PRK00549 646529008939 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 646529008940 putative MPT binding site; other site 646529008941 Competence-damaged protein; Region: CinA; pfam02464 646529008942 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 646529008943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529008944 Walker A motif; other site 646529008945 ATP binding site [chemical binding]; other site 646529008946 Walker B motif; other site 646529008947 arginine finger; other site 646529008948 Peptidase family M41; Region: Peptidase_M41; pfam01434 646529008949 DNA polymerase; Provisional; Region: 43; PHA02528 646529008950 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 646529008951 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 646529008952 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 646529008953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529008954 FeS/SAM binding site; other site 646529008955 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 646529008956 PhoU domain; Region: PhoU; pfam01895 646529008957 PhoU domain; Region: PhoU; pfam01895 646529008958 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 646529008959 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 646529008960 Walker A/P-loop; other site 646529008961 ATP binding site [chemical binding]; other site 646529008962 Q-loop/lid; other site 646529008963 ABC transporter signature motif; other site 646529008964 Walker B; other site 646529008965 D-loop; other site 646529008966 H-loop/switch region; other site 646529008967 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 646529008968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529008969 ABC-ATPase subunit interface; other site 646529008970 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 646529008971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529008972 dimer interface [polypeptide binding]; other site 646529008973 conserved gate region; other site 646529008974 putative PBP binding loops; other site 646529008975 ABC-ATPase subunit interface; other site 646529008976 PBP superfamily domain; Region: PBP_like_2; cl17296 646529008977 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 646529008978 hypothetical protein; Provisional; Region: PRK00955 646529008979 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 646529008980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 646529008981 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 646529008982 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 646529008983 Helix-turn-helix domain; Region: HTH_25; pfam13413 646529008984 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 646529008985 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 646529008986 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 646529008987 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 646529008988 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 646529008989 active site residue [active] 646529008990 AAA domain; Region: AAA_17; pfam13207 646529008991 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 646529008992 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 646529008993 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 646529008994 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 646529008995 active site 646529008996 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 646529008997 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 646529008998 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 646529008999 DNA binding residues [nucleotide binding] 646529009000 dimer interface [polypeptide binding]; other site 646529009001 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 646529009002 O-Antigen ligase; Region: Wzy_C; pfam04932 646529009003 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 646529009004 FMN binding site [chemical binding]; other site 646529009005 dimer interface [polypeptide binding]; other site 646529009006 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 646529009007 dimer interface [polypeptide binding]; other site 646529009008 Amidohydrolase; Region: Amidohydro_4; pfam13147 646529009009 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 646529009010 active site 646529009011 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 646529009012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529009013 putative substrate translocation pore; other site 646529009014 HlyD family secretion protein; Region: HlyD_3; pfam13437 646529009015 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 646529009016 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 646529009017 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 646529009018 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 646529009019 putative catalytic cysteine [active] 646529009020 gamma-glutamyl kinase; Provisional; Region: PRK05429 646529009021 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 646529009022 nucleotide binding site [chemical binding]; other site 646529009023 homotetrameric interface [polypeptide binding]; other site 646529009024 putative phosphate binding site [ion binding]; other site 646529009025 putative allosteric binding site; other site 646529009026 PUA domain; Region: PUA; pfam01472 646529009027 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 646529009028 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 646529009029 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 646529009030 tartrate dehydrogenase; Region: TTC; TIGR02089 646529009031 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 646529009032 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 646529009033 substrate binding site [chemical binding]; other site 646529009034 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 646529009035 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 646529009036 substrate binding site [chemical binding]; other site 646529009037 ligand binding site [chemical binding]; other site 646529009038 ketol-acid reductoisomerase; Provisional; Region: PRK05479 646529009039 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 646529009040 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 646529009041 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 646529009042 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 646529009043 putative valine binding site [chemical binding]; other site 646529009044 dimer interface [polypeptide binding]; other site 646529009045 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 646529009046 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 646529009047 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 646529009048 PYR/PP interface [polypeptide binding]; other site 646529009049 dimer interface [polypeptide binding]; other site 646529009050 TPP binding site [chemical binding]; other site 646529009051 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 646529009052 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 646529009053 TPP-binding site [chemical binding]; other site 646529009054 dimer interface [polypeptide binding]; other site 646529009055 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 646529009056 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 646529009057 homodimer interface [polypeptide binding]; other site 646529009058 substrate-cofactor binding pocket; other site 646529009059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529009060 catalytic residue [active] 646529009061 homoserine dehydrogenase; Provisional; Region: PRK06349 646529009062 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 646529009063 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 646529009064 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 646529009065 homoserine kinase; Provisional; Region: PRK01212 646529009066 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 646529009067 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 646529009068 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 646529009069 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 646529009070 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 646529009071 active site 646529009072 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 646529009073 Domain of unknown function DUF302; Region: DUF302; pfam03625 646529009074 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 646529009075 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 646529009076 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 646529009077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 646529009078 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 646529009079 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 646529009080 heme bH binding site [chemical binding]; other site 646529009081 intrachain domain interface; other site 646529009082 Qi binding site; other site 646529009083 heme bL binding site [chemical binding]; other site 646529009084 interchain domain interface [polypeptide binding]; other site 646529009085 Qo binding site; other site 646529009086 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 646529009087 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 646529009088 iron-sulfur cluster [ion binding]; other site 646529009089 [2Fe-2S] cluster binding site [ion binding]; other site 646529009090 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 646529009091 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 646529009092 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 646529009093 thiosulfate reductase PhsA; Provisional; Region: PRK15488 646529009094 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 646529009095 putative [Fe4-S4] binding site [ion binding]; other site 646529009096 putative molybdopterin cofactor binding site [chemical binding]; other site 646529009097 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 646529009098 putative molybdopterin cofactor binding site; other site 646529009099 putative inner membrane protein; Provisional; Region: PRK11099 646529009100 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 646529009101 heme-binding residues [chemical binding]; other site 646529009102 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 646529009103 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 646529009104 DNA binding residues [nucleotide binding] 646529009105 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 646529009106 trimerization site [polypeptide binding]; other site 646529009107 active site 646529009108 Soluble P-type ATPase [General function prediction only]; Region: COG4087 646529009109 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 646529009110 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 646529009111 Walker A motif; other site 646529009112 Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579 646529009113 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 646529009114 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 646529009115 putative homodimer interface [polypeptide binding]; other site 646529009116 putative homotetramer interface [polypeptide binding]; other site 646529009117 putative allosteric switch controlling residues; other site 646529009118 putative metal binding site [ion binding]; other site 646529009119 putative homodimer-homodimer interface [polypeptide binding]; other site 646529009120 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 646529009121 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 646529009122 N-acetyl-D-glucosamine binding site [chemical binding]; other site 646529009123 catalytic residue [active] 646529009124 dephospho-CoA kinase; Region: TIGR00152 646529009125 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 646529009126 CoA-binding site [chemical binding]; other site 646529009127 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 646529009128 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 646529009129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529009130 Walker A/P-loop; other site 646529009131 ATP binding site [chemical binding]; other site 646529009132 Q-loop/lid; other site 646529009133 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 646529009134 ABC transporter signature motif; other site 646529009135 Walker B; other site 646529009136 D-loop; other site 646529009137 ABC transporter; Region: ABC_tran_2; pfam12848 646529009138 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 646529009139 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 646529009140 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 646529009141 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 646529009142 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 646529009143 ScpA/B protein; Region: ScpA_ScpB; cl00598 646529009144 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 646529009145 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 646529009146 active site 646529009147 HIGH motif; other site 646529009148 dimer interface [polypeptide binding]; other site 646529009149 KMSKS motif; other site 646529009150 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 646529009151 Peptidase family M50; Region: Peptidase_M50; pfam02163 646529009152 active site 646529009153 putative substrate binding region [chemical binding]; other site 646529009154 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 646529009155 DHH family; Region: DHH; pfam01368 646529009156 DHHA1 domain; Region: DHHA1; pfam02272 646529009157 FOG: CBS domain [General function prediction only]; Region: COG0517 646529009158 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 646529009159 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 646529009160 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 646529009161 active site 646529009162 NTP binding site [chemical binding]; other site 646529009163 metal binding triad [ion binding]; metal-binding site 646529009164 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 646529009165 Transcriptional regulator [Transcription]; Region: LytR; COG1316 646529009166 diaminopimelate decarboxylase; Region: lysA; TIGR01048 646529009167 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 646529009168 active site 646529009169 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 646529009170 substrate binding site [chemical binding]; other site 646529009171 catalytic residues [active] 646529009172 dimer interface [polypeptide binding]; other site 646529009173 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 646529009174 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 646529009175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 646529009176 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 646529009177 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 646529009178 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 646529009179 stage V sporulation protein AD; Validated; Region: PRK08304 646529009180 stage V sporulation protein AD; Provisional; Region: PRK12404 646529009181 SpoVA protein; Region: SpoVA; cl04298 646529009182 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 646529009183 anti sigma factor interaction site; other site 646529009184 regulatory phosphorylation site [posttranslational modification]; other site 646529009185 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 646529009186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529009187 ATP binding site [chemical binding]; other site 646529009188 Mg2+ binding site [ion binding]; other site 646529009189 G-X-G motif; other site 646529009190 sporulation sigma factor SigF; Validated; Region: PRK05572 646529009191 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529009192 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 646529009193 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529009194 DNA binding residues [nucleotide binding] 646529009195 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 646529009196 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 646529009197 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 646529009198 CoA binding domain; Region: CoA_binding_2; pfam13380 646529009199 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 646529009200 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 646529009201 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 646529009202 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 646529009203 phosphopentomutase; Provisional; Region: PRK05362 646529009204 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 646529009205 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 646529009206 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 646529009207 active site 646529009208 Int/Topo IB signature motif; other site 646529009209 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 646529009210 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 646529009211 hexamer interface [polypeptide binding]; other site 646529009212 ligand binding site [chemical binding]; other site 646529009213 putative active site [active] 646529009214 NAD(P) binding site [chemical binding]; other site 646529009215 Integral membrane protein DUF95; Region: DUF95; cl00572 646529009216 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 646529009217 PHP-associated; Region: PHP_C; pfam13263 646529009218 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 646529009219 dimer interface [polypeptide binding]; other site 646529009220 ADP-ribose binding site [chemical binding]; other site 646529009221 active site 646529009222 nudix motif; other site 646529009223 metal binding site [ion binding]; metal-binding site 646529009224 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 646529009225 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 646529009226 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 646529009227 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 646529009228 TPP-binding site [chemical binding]; other site 646529009229 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 646529009230 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 646529009231 dimer interface [polypeptide binding]; other site 646529009232 PYR/PP interface [polypeptide binding]; other site 646529009233 TPP binding site [chemical binding]; other site 646529009234 substrate binding site [chemical binding]; other site 646529009235 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 646529009236 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529009237 Ferredoxin [Energy production and conversion]; Region: COG1146 646529009238 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 646529009239 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 646529009240 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 646529009241 NAD binding site [chemical binding]; other site 646529009242 Phe binding site; other site 646529009243 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529009244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529009245 putative active site [active] 646529009246 heme pocket [chemical binding]; other site 646529009247 PAS domain; Region: PAS; smart00091 646529009248 putative active site [active] 646529009249 heme pocket [chemical binding]; other site 646529009250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529009251 Walker A motif; other site 646529009252 ATP binding site [chemical binding]; other site 646529009253 Walker B motif; other site 646529009254 arginine finger; other site 646529009255 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529009256 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 646529009257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529009258 active site 646529009259 phosphorylation site [posttranslational modification] 646529009260 intermolecular recognition site; other site 646529009261 dimerization interface [polypeptide binding]; other site 646529009262 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 646529009263 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 646529009264 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 646529009265 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 646529009266 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 646529009267 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 646529009268 Walker A/P-loop; other site 646529009269 ATP binding site [chemical binding]; other site 646529009270 Q-loop/lid; other site 646529009271 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 646529009272 ABC transporter signature motif; other site 646529009273 Walker B; other site 646529009274 D-loop; other site 646529009275 H-loop/switch region; other site 646529009276 arginine repressor; Provisional; Region: PRK04280 646529009277 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 646529009278 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 646529009279 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 646529009280 ATP-NAD kinase; Region: NAD_kinase; pfam01513 646529009281 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 646529009282 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 646529009283 RNA binding surface [nucleotide binding]; other site 646529009284 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 646529009285 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 646529009286 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 646529009287 TPP-binding site; other site 646529009288 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 646529009289 PYR/PP interface [polypeptide binding]; other site 646529009290 dimer interface [polypeptide binding]; other site 646529009291 TPP binding site [chemical binding]; other site 646529009292 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 646529009293 Divergent PAP2 family; Region: DUF212; pfam02681 646529009294 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 646529009295 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 646529009296 substrate binding pocket [chemical binding]; other site 646529009297 chain length determination region; other site 646529009298 substrate-Mg2+ binding site; other site 646529009299 catalytic residues [active] 646529009300 aspartate-rich region 1; other site 646529009301 active site lid residues [active] 646529009302 aspartate-rich region 2; other site 646529009303 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 646529009304 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 646529009305 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 646529009306 generic binding surface II; other site 646529009307 generic binding surface I; other site 646529009308 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 646529009309 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 646529009310 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 646529009311 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 646529009312 homodimer interface [polypeptide binding]; other site 646529009313 NADP binding site [chemical binding]; other site 646529009314 substrate binding site [chemical binding]; other site 646529009315 putative oxidoreductase; Provisional; Region: PRK12831 646529009316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 646529009317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 646529009318 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 646529009319 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 646529009320 FAD binding pocket [chemical binding]; other site 646529009321 FAD binding motif [chemical binding]; other site 646529009322 phosphate binding motif [ion binding]; other site 646529009323 beta-alpha-beta structure motif; other site 646529009324 NAD binding pocket [chemical binding]; other site 646529009325 Iron coordination center [ion binding]; other site 646529009326 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 646529009327 putative RNA binding site [nucleotide binding]; other site 646529009328 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 646529009329 Asp23 family; Region: Asp23; pfam03780 646529009330 Asp23 family; Region: Asp23; pfam03780 646529009331 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 646529009332 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 646529009333 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 646529009334 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 646529009335 pyruvate carboxylase subunit B; Validated; Region: PRK09282 646529009336 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 646529009337 active site 646529009338 catalytic residues [active] 646529009339 metal binding site [ion binding]; metal-binding site 646529009340 homodimer binding site [polypeptide binding]; other site 646529009341 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 646529009342 carboxyltransferase (CT) interaction site; other site 646529009343 biotinylation site [posttranslational modification]; other site 646529009344 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 646529009345 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 646529009346 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 646529009347 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 646529009348 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 646529009349 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 646529009350 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 646529009351 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 646529009352 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 646529009353 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 646529009354 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 646529009355 elongation factor P; Validated; Region: PRK00529 646529009356 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 646529009357 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 646529009358 RNA binding site [nucleotide binding]; other site 646529009359 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 646529009360 RNA binding site [nucleotide binding]; other site 646529009361 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 646529009362 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 646529009363 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 646529009364 active site 646529009365 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 646529009366 Dehydroquinase class II; Region: DHquinase_II; pfam01220 646529009367 trimer interface [polypeptide binding]; other site 646529009368 active site 646529009369 dimer interface [polypeptide binding]; other site 646529009370 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 646529009371 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 646529009372 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 646529009373 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 646529009374 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 646529009375 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 646529009376 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 646529009377 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 646529009378 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 646529009379 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 646529009380 Walker A motif; other site 646529009381 ATP binding site [chemical binding]; other site 646529009382 Walker B motif; other site 646529009383 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 646529009384 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 646529009385 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 646529009386 Walker A motif; other site 646529009387 ATP binding site [chemical binding]; other site 646529009388 Walker B motif; other site 646529009389 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 646529009390 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 646529009391 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 646529009392 active site 646529009393 dimer interface [polypeptide binding]; other site 646529009394 metal binding site [ion binding]; metal-binding site 646529009395 shikimate kinase; Provisional; Region: PRK13947 646529009396 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 646529009397 ADP binding site [chemical binding]; other site 646529009398 magnesium binding site [ion binding]; other site 646529009399 putative shikimate binding site; other site 646529009400 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 646529009401 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 646529009402 Tetramer interface [polypeptide binding]; other site 646529009403 active site 646529009404 FMN-binding site [chemical binding]; other site 646529009405 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 646529009406 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 646529009407 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 646529009408 shikimate binding site; other site 646529009409 NAD(P) binding site [chemical binding]; other site 646529009410 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 646529009411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 646529009412 active site 646529009413 motif I; other site 646529009414 motif II; other site 646529009415 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 646529009416 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 646529009417 DltD N-terminal region; Region: DltD_N; pfam04915 646529009418 DltD central region; Region: DltD_M; pfam04918 646529009419 DltD C-terminal region; Region: DltD_C; pfam04914 646529009420 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 646529009421 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 646529009422 acyl-activating enzyme (AAE) consensus motif; other site 646529009423 AMP binding site [chemical binding]; other site 646529009424 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 646529009425 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 646529009426 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 646529009427 HlyD family secretion protein; Region: HlyD_3; pfam13437 646529009428 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 646529009429 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529009430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529009431 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 646529009432 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 646529009433 Walker A/P-loop; other site 646529009434 ATP binding site [chemical binding]; other site 646529009435 Q-loop/lid; other site 646529009436 ABC transporter signature motif; other site 646529009437 Walker B; other site 646529009438 D-loop; other site 646529009439 H-loop/switch region; other site 646529009440 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 646529009441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 646529009442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 646529009443 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 646529009444 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 646529009445 catalytic residues [active] 646529009446 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 646529009447 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 646529009448 RAVE protein 1 C terminal; Region: Rav1p_C; pfam12234 646529009449 benzoate transport; Region: 2A0115; TIGR00895 646529009450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529009451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529009452 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 646529009453 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 646529009454 ligand binding site [chemical binding]; other site 646529009455 flexible hinge region; other site 646529009456 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 646529009457 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 646529009458 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 646529009459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 646529009460 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 646529009461 Predicted membrane protein [Function unknown]; Region: COG2860 646529009462 UPF0126 domain; Region: UPF0126; pfam03458 646529009463 UPF0126 domain; Region: UPF0126; pfam03458 646529009464 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 646529009465 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 646529009466 metal binding site [ion binding]; metal-binding site 646529009467 dimer interface [polypeptide binding]; other site 646529009468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529009469 putative transporter; Provisional; Region: PRK10504 646529009470 putative substrate translocation pore; other site 646529009471 HEAT repeats; Region: HEAT_2; pfam13646 646529009472 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 646529009473 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 646529009474 DXD motif; other site 646529009475 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 646529009476 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 646529009477 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 646529009478 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529009479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529009480 metal binding site [ion binding]; metal-binding site 646529009481 active site 646529009482 I-site; other site 646529009483 Response regulator receiver domain; Region: Response_reg; pfam00072 646529009484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529009485 active site 646529009486 phosphorylation site [posttranslational modification] 646529009487 intermolecular recognition site; other site 646529009488 dimerization interface [polypeptide binding]; other site 646529009489 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 646529009490 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 646529009491 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 646529009492 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 646529009493 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 646529009494 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 646529009495 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 646529009496 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 646529009497 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 646529009498 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 646529009499 Walker A/P-loop; other site 646529009500 ATP binding site [chemical binding]; other site 646529009501 Q-loop/lid; other site 646529009502 ABC transporter signature motif; other site 646529009503 Walker B; other site 646529009504 D-loop; other site 646529009505 H-loop/switch region; other site 646529009506 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 646529009507 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 646529009508 Walker A/P-loop; other site 646529009509 ATP binding site [chemical binding]; other site 646529009510 Q-loop/lid; other site 646529009511 ABC transporter signature motif; other site 646529009512 Walker B; other site 646529009513 D-loop; other site 646529009514 H-loop/switch region; other site 646529009515 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 646529009516 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 646529009517 putative dimer interface [polypeptide binding]; other site 646529009518 active site pocket [active] 646529009519 putative cataytic base [active] 646529009520 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529009521 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 646529009522 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529009523 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529009524 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 646529009525 ATP binding site [chemical binding]; other site 646529009526 Mg2+ binding site [ion binding]; other site 646529009527 G-X-G motif; other site 646529009528 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 646529009529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529009530 active site 646529009531 phosphorylation site [posttranslational modification] 646529009532 intermolecular recognition site; other site 646529009533 dimerization interface [polypeptide binding]; other site 646529009534 LytTr DNA-binding domain; Region: LytTR; pfam04397 646529009535 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 646529009536 Transposase domain (DUF772); Region: DUF772; pfam05598 646529009537 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 646529009538 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 646529009539 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 646529009540 PAS fold; Region: PAS_4; pfam08448 646529009541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 646529009542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529009543 dimer interface [polypeptide binding]; other site 646529009544 phosphorylation site [posttranslational modification] 646529009545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529009546 ATP binding site [chemical binding]; other site 646529009547 Mg2+ binding site [ion binding]; other site 646529009548 G-X-G motif; other site 646529009549 Staphylococcal AgrD protein; Region: AgrD; cl05477 646529009550 Accessory gene regulator B; Region: AgrB; pfam04647 646529009551 H+ Antiporter protein; Region: 2A0121; TIGR00900 646529009552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529009553 putative substrate translocation pore; other site 646529009554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 646529009555 putative DNA binding site [nucleotide binding]; other site 646529009556 dimerization interface [polypeptide binding]; other site 646529009557 putative Zn2+ binding site [ion binding]; other site 646529009558 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 646529009559 sporulation sigma factor SigK; Reviewed; Region: PRK05803 646529009560 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529009561 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529009562 DNA binding residues [nucleotide binding] 646529009563 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 646529009564 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 646529009565 PilX N-terminal; Region: PilX_N; pfam14341 646529009566 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 646529009567 aromatic chitin/cellulose binding site residues [chemical binding]; other site 646529009568 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 646529009569 aromatic chitin/cellulose binding site residues [chemical binding]; other site 646529009570 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 646529009571 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 646529009572 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 646529009573 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 646529009574 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 646529009575 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 646529009576 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 646529009577 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 646529009578 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 646529009579 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 646529009580 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 646529009581 Walker A motif; other site 646529009582 ATP binding site [chemical binding]; other site 646529009583 Walker B motif; other site 646529009584 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 646529009585 O-Antigen ligase; Region: Wzy_C; pfam04932 646529009586 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 646529009587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529009588 TPR motif; other site 646529009589 binding surface 646529009590 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529009591 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529009592 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529009593 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 646529009594 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 646529009595 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 646529009596 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 646529009597 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 646529009598 Peptidase family U32; Region: Peptidase_U32; pfam01136 646529009599 YceG-like family; Region: YceG; pfam02618 646529009600 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 646529009601 dimerization interface [polypeptide binding]; other site 646529009602 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 646529009603 VanW like protein; Region: VanW; pfam04294 646529009604 G5 domain; Region: G5; pfam07501 646529009605 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 646529009606 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 646529009607 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 646529009608 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 646529009609 active site 646529009610 catalytic tetrad [active] 646529009611 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529009612 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529009613 hypothetical protein; Provisional; Region: PRK05473 646529009614 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 646529009615 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 646529009616 motif 1; other site 646529009617 active site 646529009618 motif 2; other site 646529009619 motif 3; other site 646529009620 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 646529009621 DHHA1 domain; Region: DHHA1; pfam02272 646529009622 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 646529009623 Domain of unknown function DUF20; Region: UPF0118; pfam01594 646529009624 PRC-barrel domain; Region: PRC; pfam05239 646529009625 PRC-barrel domain; Region: PRC; pfam05239 646529009626 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 646529009627 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 646529009628 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 646529009629 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 646529009630 trimerization site [polypeptide binding]; other site 646529009631 active site 646529009632 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 646529009633 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 646529009634 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 646529009635 catalytic residue [active] 646529009636 Predicted transcriptional regulator [Transcription]; Region: COG1959 646529009637 Transcriptional regulator; Region: Rrf2; cl17282 646529009638 recombination factor protein RarA; Reviewed; Region: PRK13342 646529009639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529009640 Walker A motif; other site 646529009641 ATP binding site [chemical binding]; other site 646529009642 Walker B motif; other site 646529009643 arginine finger; other site 646529009644 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 646529009645 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 646529009646 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 646529009647 catalytic residues [active] 646529009648 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 646529009649 putative homodimer interface [polypeptide binding]; other site 646529009650 putative homotetramer interface [polypeptide binding]; other site 646529009651 putative allosteric switch controlling residues; other site 646529009652 putative metal binding site [ion binding]; other site 646529009653 putative homodimer-homodimer interface [polypeptide binding]; other site 646529009654 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 646529009655 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 646529009656 dimer interface [polypeptide binding]; other site 646529009657 anticodon binding site; other site 646529009658 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 646529009659 homodimer interface [polypeptide binding]; other site 646529009660 motif 1; other site 646529009661 active site 646529009662 motif 2; other site 646529009663 GAD domain; Region: GAD; pfam02938 646529009664 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 646529009665 motif 3; other site 646529009666 histidyl-tRNA synthetase; Region: hisS; TIGR00442 646529009667 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 646529009668 dimer interface [polypeptide binding]; other site 646529009669 motif 1; other site 646529009670 active site 646529009671 motif 2; other site 646529009672 motif 3; other site 646529009673 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 646529009674 anticodon binding site; other site 646529009675 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 646529009676 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 646529009677 putative active site [active] 646529009678 dimerization interface [polypeptide binding]; other site 646529009679 putative tRNAtyr binding site [nucleotide binding]; other site 646529009680 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 646529009681 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529009682 Zn2+ binding site [ion binding]; other site 646529009683 Mg2+ binding site [ion binding]; other site 646529009684 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 646529009685 synthetase active site [active] 646529009686 NTP binding site [chemical binding]; other site 646529009687 metal binding site [ion binding]; metal-binding site 646529009688 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 646529009689 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 646529009690 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 646529009691 active site 646529009692 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 646529009693 DHH family; Region: DHH; pfam01368 646529009694 DHHA1 domain; Region: DHHA1; pfam02272 646529009695 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 646529009696 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 646529009697 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 646529009698 putative active site [active] 646529009699 putative metal binding site [ion binding]; other site 646529009700 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 646529009701 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 646529009702 Protein export membrane protein; Region: SecD_SecF; pfam02355 646529009703 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 646529009704 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 646529009705 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529009706 Zn2+ binding site [ion binding]; other site 646529009707 Mg2+ binding site [ion binding]; other site 646529009708 Preprotein translocase subunit; Region: YajC; pfam02699 646529009709 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 646529009710 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 646529009711 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 646529009712 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 646529009713 Stage II sporulation protein; Region: SpoIID; pfam08486 646529009714 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 646529009715 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 646529009716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529009717 Walker A motif; other site 646529009718 ATP binding site [chemical binding]; other site 646529009719 Walker B motif; other site 646529009720 arginine finger; other site 646529009721 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 646529009722 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 646529009723 RuvA N terminal domain; Region: RuvA_N; pfam01330 646529009724 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 646529009725 DNA binding site [nucleotide binding] 646529009726 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 646529009727 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 646529009728 active site 646529009729 putative DNA-binding cleft [nucleotide binding]; other site 646529009730 dimer interface [polypeptide binding]; other site 646529009731 hypothetical protein; Validated; Region: PRK00110 646529009732 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 646529009733 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 646529009734 dimer interface [polypeptide binding]; other site 646529009735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529009736 catalytic residue [active] 646529009737 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 646529009738 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 646529009739 dimerization interface [polypeptide binding]; other site 646529009740 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 646529009741 ATP binding site [chemical binding]; other site 646529009742 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 646529009743 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 646529009744 HupF/HypC family; Region: HupF_HypC; pfam01455 646529009745 Acylphosphatase; Region: Acylphosphatase; pfam00708 646529009746 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 646529009747 HypF finger; Region: zf-HYPF; pfam07503 646529009748 HypF finger; Region: zf-HYPF; pfam07503 646529009749 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 646529009750 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 646529009751 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 646529009752 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 646529009753 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 646529009754 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 646529009755 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 646529009756 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 646529009757 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 646529009758 putative substrate-binding site; other site 646529009759 nickel binding site [ion binding]; other site 646529009760 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 646529009761 G1 box; other site 646529009762 GTP/Mg2+ binding site [chemical binding]; other site 646529009763 G2 box; other site 646529009764 Switch I region; other site 646529009765 G3 box; other site 646529009766 Switch II region; other site 646529009767 G4 box; other site 646529009768 G5 box; other site 646529009769 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK03824 646529009770 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 646529009771 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 646529009772 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 646529009773 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 646529009774 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529009775 putative CheW interface [polypeptide binding]; other site 646529009776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529009777 D-galactonate transporter; Region: 2A0114; TIGR00893 646529009778 putative substrate translocation pore; other site 646529009779 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 646529009780 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 646529009781 ATP binding site [chemical binding]; other site 646529009782 putative Mg++ binding site [ion binding]; other site 646529009783 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529009784 nucleotide binding region [chemical binding]; other site 646529009785 ATP-binding site [chemical binding]; other site 646529009786 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 646529009787 HRDC domain; Region: HRDC; pfam00570 646529009788 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 646529009789 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 646529009790 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529009791 FeS/SAM binding site; other site 646529009792 putative transporter; Provisional; Region: PRK11021 646529009793 Transcriptional regulator [Transcription]; Region: LysR; COG0583 646529009794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 646529009795 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 646529009796 dimerization interface [polypeptide binding]; other site 646529009797 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 646529009798 EamA-like transporter family; Region: EamA; pfam00892 646529009799 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 646529009800 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 646529009801 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 646529009802 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 646529009803 dihydrodipicolinate synthase; Region: dapA; TIGR00674 646529009804 dimer interface [polypeptide binding]; other site 646529009805 active site 646529009806 catalytic residue [active] 646529009807 aspartate kinase I; Reviewed; Region: PRK08210 646529009808 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 646529009809 putative catalytic residues [active] 646529009810 putative nucleotide binding site [chemical binding]; other site 646529009811 putative aspartate binding site [chemical binding]; other site 646529009812 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 646529009813 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 646529009814 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 646529009815 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 646529009816 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 646529009817 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 646529009818 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 646529009819 dihydrodipicolinate reductase; Provisional; Region: PRK00048 646529009820 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 646529009821 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 646529009822 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 646529009823 Uncharacterized conserved protein (DUF2036); Region: DUF2036; pfam09724 646529009824 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 646529009825 trimer interface [polypeptide binding]; other site 646529009826 active site 646529009827 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 646529009828 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 646529009829 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 646529009830 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 646529009831 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 646529009832 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 646529009833 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 646529009834 NodB motif; other site 646529009835 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 646529009836 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 646529009837 RNase E interface [polypeptide binding]; other site 646529009838 trimer interface [polypeptide binding]; other site 646529009839 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 646529009840 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 646529009841 RNase E interface [polypeptide binding]; other site 646529009842 trimer interface [polypeptide binding]; other site 646529009843 active site 646529009844 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 646529009845 putative nucleic acid binding region [nucleotide binding]; other site 646529009846 G-X-X-G motif; other site 646529009847 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 646529009848 RNA binding site [nucleotide binding]; other site 646529009849 domain interface; other site 646529009850 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 646529009851 16S/18S rRNA binding site [nucleotide binding]; other site 646529009852 S13e-L30e interaction site [polypeptide binding]; other site 646529009853 25S rRNA binding site [nucleotide binding]; other site 646529009854 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 646529009855 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 646529009856 active site 646529009857 Riboflavin kinase; Region: Flavokinase; pfam01687 646529009858 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 646529009859 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 646529009860 RNA binding site [nucleotide binding]; other site 646529009861 active site 646529009862 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 646529009863 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 646529009864 DHH family; Region: DHH; pfam01368 646529009865 DHHA1 domain; Region: DHHA1; pfam02272 646529009866 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 646529009867 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 646529009868 translation initiation factor IF-2; Region: IF-2; TIGR00487 646529009869 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 646529009870 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 646529009871 G1 box; other site 646529009872 putative GEF interaction site [polypeptide binding]; other site 646529009873 GTP/Mg2+ binding site [chemical binding]; other site 646529009874 Switch I region; other site 646529009875 G2 box; other site 646529009876 G3 box; other site 646529009877 Switch II region; other site 646529009878 G4 box; other site 646529009879 G5 box; other site 646529009880 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 646529009881 Translation-initiation factor 2; Region: IF-2; pfam11987 646529009882 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 646529009883 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 646529009884 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 646529009885 putative RNA binding cleft [nucleotide binding]; other site 646529009886 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 646529009887 NusA N-terminal domain; Region: NusA_N; pfam08529 646529009888 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 646529009889 RNA binding site [nucleotide binding]; other site 646529009890 homodimer interface [polypeptide binding]; other site 646529009891 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 646529009892 G-X-X-G motif; other site 646529009893 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 646529009894 G-X-X-G motif; other site 646529009895 ribosome maturation protein RimP; Reviewed; Region: PRK00092 646529009896 Sm and related proteins; Region: Sm_like; cl00259 646529009897 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 646529009898 putative oligomer interface [polypeptide binding]; other site 646529009899 putative RNA binding site [nucleotide binding]; other site 646529009900 prolyl-tRNA synthetase; Provisional; Region: PRK09194 646529009901 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 646529009902 dimer interface [polypeptide binding]; other site 646529009903 motif 1; other site 646529009904 active site 646529009905 motif 2; other site 646529009906 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 646529009907 putative deacylase active site [active] 646529009908 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 646529009909 active site 646529009910 motif 3; other site 646529009911 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 646529009912 anticodon binding site; other site 646529009913 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 646529009914 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 646529009915 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 646529009916 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 646529009917 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 646529009918 active site 646529009919 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 646529009920 protein binding site [polypeptide binding]; other site 646529009921 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 646529009922 putative substrate binding region [chemical binding]; other site 646529009923 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 646529009924 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 646529009925 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 646529009926 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 646529009927 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 646529009928 Domain of unknown function DUF20; Region: UPF0118; pfam01594 646529009929 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 646529009930 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 646529009931 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 646529009932 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 646529009933 catalytic residue [active] 646529009934 putative FPP diphosphate binding site; other site 646529009935 putative FPP binding hydrophobic cleft; other site 646529009936 dimer interface [polypeptide binding]; other site 646529009937 putative IPP diphosphate binding site; other site 646529009938 ribosome recycling factor; Reviewed; Region: frr; PRK00083 646529009939 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 646529009940 hinge region; other site 646529009941 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 646529009942 putative nucleotide binding site [chemical binding]; other site 646529009943 uridine monophosphate binding site [chemical binding]; other site 646529009944 homohexameric interface [polypeptide binding]; other site 646529009945 elongation factor Ts; Reviewed; Region: tsf; PRK12332 646529009946 UBA/TS-N domain; Region: UBA; pfam00627 646529009947 Elongation factor TS; Region: EF_TS; pfam00889 646529009948 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 646529009949 rRNA interaction site [nucleotide binding]; other site 646529009950 S8 interaction site; other site 646529009951 putative laminin-1 binding site; other site 646529009952 transcriptional repressor CodY; Validated; Region: PRK04158 646529009953 CodY GAF-like domain; Region: CodY; pfam06018 646529009954 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 646529009955 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 646529009956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529009957 Walker A motif; other site 646529009958 ATP binding site [chemical binding]; other site 646529009959 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 646529009960 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 646529009961 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 646529009962 active site 646529009963 HslU subunit interaction site [polypeptide binding]; other site 646529009964 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 646529009965 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 646529009966 active site 646529009967 Int/Topo IB signature motif; other site 646529009968 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 646529009969 Glucose inhibited division protein A; Region: GIDA; pfam01134 646529009970 DNA topoisomerase I; Validated; Region: PRK05582 646529009971 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 646529009972 active site 646529009973 interdomain interaction site; other site 646529009974 putative metal-binding site [ion binding]; other site 646529009975 nucleotide binding site [chemical binding]; other site 646529009976 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 646529009977 domain I; other site 646529009978 DNA binding groove [nucleotide binding] 646529009979 phosphate binding site [ion binding]; other site 646529009980 domain II; other site 646529009981 domain III; other site 646529009982 nucleotide binding site [chemical binding]; other site 646529009983 catalytic site [active] 646529009984 domain IV; other site 646529009985 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 646529009986 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 646529009987 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 646529009988 DNA protecting protein DprA; Region: dprA; TIGR00732 646529009989 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 646529009990 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 646529009991 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 646529009992 putative DNA binding site [nucleotide binding]; other site 646529009993 putative homodimer interface [polypeptide binding]; other site 646529009994 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 646529009995 PemK-like protein; Region: PemK; cl00995 646529009996 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 646529009997 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 646529009998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529009999 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529010000 dimerization interface [polypeptide binding]; other site 646529010001 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529010002 dimer interface [polypeptide binding]; other site 646529010003 phosphorylation site [posttranslational modification] 646529010004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529010005 ATP binding site [chemical binding]; other site 646529010006 G-X-G motif; other site 646529010007 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529010008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529010009 active site 646529010010 phosphorylation site [posttranslational modification] 646529010011 intermolecular recognition site; other site 646529010012 dimerization interface [polypeptide binding]; other site 646529010013 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529010014 DNA binding site [nucleotide binding] 646529010015 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 646529010016 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 646529010017 TM-ABC transporter signature motif; other site 646529010018 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 646529010019 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 646529010020 TM-ABC transporter signature motif; other site 646529010021 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 646529010022 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 646529010023 Walker A/P-loop; other site 646529010024 ATP binding site [chemical binding]; other site 646529010025 Q-loop/lid; other site 646529010026 ABC transporter signature motif; other site 646529010027 Walker B; other site 646529010028 D-loop; other site 646529010029 H-loop/switch region; other site 646529010030 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 646529010031 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 646529010032 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 646529010033 putative ligand binding site [chemical binding]; other site 646529010034 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 646529010035 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 646529010036 trimer interface I [polypeptide binding]; other site 646529010037 putative substrate binding pocket [chemical binding]; other site 646529010038 trimer interface II [polypeptide binding]; other site 646529010039 ribonuclease Z; Reviewed; Region: PRK00055 646529010040 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 646529010041 Uncharacterized conserved protein [Function unknown]; Region: COG2006 646529010042 4Fe-4S binding domain; Region: Fer4; cl02805 646529010043 4Fe-4S binding domain; Region: Fer4; pfam00037 646529010044 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 646529010045 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 646529010046 DNA binding residues [nucleotide binding] 646529010047 putative dimer interface [polypeptide binding]; other site 646529010048 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 646529010049 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 646529010050 NodB motif; other site 646529010051 active site 646529010052 catalytic site [active] 646529010053 metal binding site [ion binding]; metal-binding site 646529010054 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 646529010055 polypeptide substrate binding site [polypeptide binding]; other site 646529010056 active site 646529010057 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 646529010058 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 646529010059 NAD(P) binding site [chemical binding]; other site 646529010060 catalytic residues [active] 646529010061 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 646529010062 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 646529010063 putative active site [active] 646529010064 metal binding site [ion binding]; metal-binding site 646529010065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529010066 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529010067 putative substrate translocation pore; other site 646529010068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529010069 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 646529010070 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 646529010071 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 646529010072 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 646529010073 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 646529010074 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 646529010075 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 646529010076 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 646529010077 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529010078 Walker A/P-loop; other site 646529010079 ATP binding site [chemical binding]; other site 646529010080 Q-loop/lid; other site 646529010081 ABC transporter signature motif; other site 646529010082 Walker B; other site 646529010083 D-loop; other site 646529010084 H-loop/switch region; other site 646529010085 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 646529010086 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 646529010087 HlyD family secretion protein; Region: HlyD_3; pfam13437 646529010088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529010089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529010090 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 646529010091 amino acid transporter; Region: 2A0306; TIGR00909 646529010092 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529010093 dimerization interface [polypeptide binding]; other site 646529010094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 646529010095 Histidine kinase; Region: HisKA_3; pfam07730 646529010096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529010097 ATP binding site [chemical binding]; other site 646529010098 Mg2+ binding site [ion binding]; other site 646529010099 G-X-G motif; other site 646529010100 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 646529010101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529010102 active site 646529010103 phosphorylation site [posttranslational modification] 646529010104 intermolecular recognition site; other site 646529010105 dimerization interface [polypeptide binding]; other site 646529010106 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 646529010107 DNA binding residues [nucleotide binding] 646529010108 dimerization interface [polypeptide binding]; other site 646529010109 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 646529010110 Ligand Binding Site [chemical binding]; other site 646529010111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529010112 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529010113 putative substrate translocation pore; other site 646529010114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529010115 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 646529010116 Ligand Binding Site [chemical binding]; other site 646529010117 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 646529010118 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 646529010119 substrate binding pocket [chemical binding]; other site 646529010120 membrane-bound complex binding site; other site 646529010121 hinge residues; other site 646529010122 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529010123 dimer interface [polypeptide binding]; other site 646529010124 putative CheW interface [polypeptide binding]; other site 646529010125 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 646529010126 Coenzyme A transferase; Region: CoA_trans; cl17247 646529010127 Coenzyme A transferase; Region: CoA_trans; smart00882 646529010128 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 646529010129 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 646529010130 FAD binding site [chemical binding]; other site 646529010131 homotetramer interface [polypeptide binding]; other site 646529010132 substrate binding pocket [chemical binding]; other site 646529010133 catalytic base [active] 646529010134 putative acyltransferase; Provisional; Region: PRK05790 646529010135 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 646529010136 dimer interface [polypeptide binding]; other site 646529010137 active site 646529010138 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 646529010139 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 646529010140 substrate binding site [chemical binding]; other site 646529010141 oxyanion hole (OAH) forming residues; other site 646529010142 trimer interface [polypeptide binding]; other site 646529010143 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 646529010144 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 646529010145 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 646529010146 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 646529010147 FOG: CBS domain [General function prediction only]; Region: COG0517 646529010148 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 646529010149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529010150 putative active site [active] 646529010151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529010152 Walker A motif; other site 646529010153 ATP binding site [chemical binding]; other site 646529010154 Walker B motif; other site 646529010155 arginine finger; other site 646529010156 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529010157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529010158 Coenzyme A binding pocket [chemical binding]; other site 646529010159 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 646529010160 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 646529010161 active site 646529010162 dimer interface [polypeptide binding]; other site 646529010163 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 646529010164 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 646529010165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529010166 Walker A motif; other site 646529010167 ATP binding site [chemical binding]; other site 646529010168 Walker B motif; other site 646529010169 arginine finger; other site 646529010170 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 646529010171 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 646529010172 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529010173 dimerization interface [polypeptide binding]; other site 646529010174 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 646529010175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529010176 dimer interface [polypeptide binding]; other site 646529010177 phosphorylation site [posttranslational modification] 646529010178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529010179 ATP binding site [chemical binding]; other site 646529010180 Mg2+ binding site [ion binding]; other site 646529010181 G-X-G motif; other site 646529010182 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529010183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529010184 active site 646529010185 phosphorylation site [posttranslational modification] 646529010186 intermolecular recognition site; other site 646529010187 dimerization interface [polypeptide binding]; other site 646529010188 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529010189 DNA binding site [nucleotide binding] 646529010190 hypothetical protein; Reviewed; Region: PRK12497 646529010191 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 646529010192 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 646529010193 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 646529010194 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 646529010195 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 646529010196 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 646529010197 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 646529010198 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 646529010199 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 646529010200 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 646529010201 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 646529010202 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 646529010203 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529010204 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 646529010205 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 646529010206 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 646529010207 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 646529010208 NADH dehydrogenase subunit B; Validated; Region: PRK06411 646529010209 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 646529010210 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 646529010211 RNA/DNA hybrid binding site [nucleotide binding]; other site 646529010212 active site 646529010213 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 646529010214 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 646529010215 GTP/Mg2+ binding site [chemical binding]; other site 646529010216 G4 box; other site 646529010217 G5 box; other site 646529010218 G1 box; other site 646529010219 Switch I region; other site 646529010220 G2 box; other site 646529010221 G3 box; other site 646529010222 Switch II region; other site 646529010223 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 646529010224 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 646529010225 Catalytic site [active] 646529010226 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 646529010227 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 646529010228 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 646529010229 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 646529010230 RimM N-terminal domain; Region: RimM; pfam01782 646529010231 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 646529010232 hypothetical protein; Provisional; Region: PRK00468 646529010233 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 646529010234 signal recognition particle protein; Provisional; Region: PRK10867 646529010235 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 646529010236 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 646529010237 P loop; other site 646529010238 GTP binding site [chemical binding]; other site 646529010239 Signal peptide binding domain; Region: SRP_SPB; pfam02978 646529010240 putative DNA-binding protein; Validated; Region: PRK00118 646529010241 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 646529010242 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 646529010243 active site 646529010244 putative substrate binding pocket [chemical binding]; other site 646529010245 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 646529010246 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 646529010247 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 646529010248 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 646529010249 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 646529010250 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 646529010251 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 646529010252 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 646529010253 Walker A/P-loop; other site 646529010254 ATP binding site [chemical binding]; other site 646529010255 Q-loop/lid; other site 646529010256 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 646529010257 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 646529010258 ABC transporter signature motif; other site 646529010259 Walker B; other site 646529010260 D-loop; other site 646529010261 H-loop/switch region; other site 646529010262 ribonuclease III; Reviewed; Region: rnc; PRK00102 646529010263 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 646529010264 dimerization interface [polypeptide binding]; other site 646529010265 active site 646529010266 metal binding site [ion binding]; metal-binding site 646529010267 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 646529010268 dsRNA binding site [nucleotide binding]; other site 646529010269 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 646529010270 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 646529010271 dimer interface [polypeptide binding]; other site 646529010272 active site 646529010273 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 646529010274 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 646529010275 FMN binding site [chemical binding]; other site 646529010276 substrate binding site [chemical binding]; other site 646529010277 putative catalytic residue [active] 646529010278 acyl carrier protein; Provisional; Region: acpP; PRK00982 646529010279 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 646529010280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 646529010281 NAD(P) binding site [chemical binding]; other site 646529010282 active site 646529010283 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 646529010284 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 646529010285 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 646529010286 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 646529010287 FMN binding site [chemical binding]; other site 646529010288 substrate binding site [chemical binding]; other site 646529010289 putative catalytic residue [active] 646529010290 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 646529010291 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 646529010292 dimer interface [polypeptide binding]; other site 646529010293 active site 646529010294 CoA binding pocket [chemical binding]; other site 646529010295 putative phosphate acyltransferase; Provisional; Region: PRK05331 646529010296 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 646529010297 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 646529010298 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 646529010299 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 646529010300 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 646529010301 propionate/acetate kinase; Provisional; Region: PRK12379 646529010302 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 646529010303 Nucleoside recognition; Region: Gate; pfam07670 646529010304 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 646529010305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529010306 S-adenosylmethionine binding site [chemical binding]; other site 646529010307 germination protease; Provisional; Region: PRK12362 646529010308 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 646529010309 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 646529010310 generic binding surface II; other site 646529010311 ssDNA binding site; other site 646529010312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 646529010313 ATP binding site [chemical binding]; other site 646529010314 putative Mg++ binding site [ion binding]; other site 646529010315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529010316 nucleotide binding region [chemical binding]; other site 646529010317 ATP-binding site [chemical binding]; other site 646529010318 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 646529010319 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 646529010320 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 646529010321 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 646529010322 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 646529010323 putative L-serine binding site [chemical binding]; other site 646529010324 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 646529010325 DAK2 domain; Region: Dak2; pfam02734 646529010326 Asp23 family; Region: Asp23; pfam03780 646529010327 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 646529010328 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 646529010329 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 646529010330 dimerization interface [polypeptide binding]; other site 646529010331 domain crossover interface; other site 646529010332 redox-dependent activation switch; other site 646529010333 Thiamine pyrophosphokinase; Region: TPK; cd07995 646529010334 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 646529010335 active site 646529010336 dimerization interface [polypeptide binding]; other site 646529010337 thiamine binding site [chemical binding]; other site 646529010338 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 646529010339 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 646529010340 substrate binding site [chemical binding]; other site 646529010341 hexamer interface [polypeptide binding]; other site 646529010342 metal binding site [ion binding]; metal-binding site 646529010343 GTPase RsgA; Reviewed; Region: PRK00098 646529010344 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 646529010345 RNA binding site [nucleotide binding]; other site 646529010346 homodimer interface [polypeptide binding]; other site 646529010347 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 646529010348 GTPase/Zn-binding domain interface [polypeptide binding]; other site 646529010349 GTP/Mg2+ binding site [chemical binding]; other site 646529010350 G4 box; other site 646529010351 G5 box; other site 646529010352 G1 box; other site 646529010353 Switch I region; other site 646529010354 G2 box; other site 646529010355 G3 box; other site 646529010356 Switch II region; other site 646529010357 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 646529010358 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 646529010359 active site 646529010360 ATP binding site [chemical binding]; other site 646529010361 substrate binding site [chemical binding]; other site 646529010362 activation loop (A-loop); other site 646529010363 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 646529010364 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 646529010365 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 646529010366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 646529010367 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 646529010368 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 646529010369 active site 646529010370 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 646529010371 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 646529010372 phosphopeptide binding site; other site 646529010373 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 646529010374 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 646529010375 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 646529010376 phosphopeptide binding site; other site 646529010377 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 646529010378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529010379 FeS/SAM binding site; other site 646529010380 16S rRNA methyltransferase B; Provisional; Region: PRK14902 646529010381 NusB family; Region: NusB; pfam01029 646529010382 putative RNA binding site [nucleotide binding]; other site 646529010383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529010384 S-adenosylmethionine binding site [chemical binding]; other site 646529010385 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 646529010386 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 646529010387 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 646529010388 putative active site [active] 646529010389 substrate binding site [chemical binding]; other site 646529010390 putative cosubstrate binding site; other site 646529010391 catalytic site [active] 646529010392 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 646529010393 substrate binding site [chemical binding]; other site 646529010394 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 646529010395 active site 646529010396 catalytic residues [active] 646529010397 metal binding site [ion binding]; metal-binding site 646529010398 primosome assembly protein PriA; Validated; Region: PRK05580 646529010399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 646529010400 ATP binding site [chemical binding]; other site 646529010401 putative Mg++ binding site [ion binding]; other site 646529010402 helicase superfamily c-terminal domain; Region: HELICc; smart00490 646529010403 ATP-binding site [chemical binding]; other site 646529010404 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 646529010405 ACT domain-containing protein [General function prediction only]; Region: COG4747 646529010406 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 646529010407 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 646529010408 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 646529010409 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 646529010410 acyl-activating enzyme (AAE) consensus motif; other site 646529010411 AMP binding site [chemical binding]; other site 646529010412 active site 646529010413 CoA binding site [chemical binding]; other site 646529010414 S-adenosylmethionine synthetase; Validated; Region: PRK05250 646529010415 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 646529010416 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 646529010417 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 646529010418 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 646529010419 Flavoprotein; Region: Flavoprotein; pfam02441 646529010420 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 646529010421 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 646529010422 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 646529010423 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 646529010424 catalytic site [active] 646529010425 G-X2-G-X-G-K; other site 646529010426 hypothetical protein; Provisional; Region: PRK04323 646529010427 hypothetical protein; Provisional; Region: PRK11820 646529010428 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 646529010429 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 646529010430 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 646529010431 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 646529010432 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 646529010433 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 646529010434 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 646529010435 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 646529010436 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 646529010437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 646529010438 motif II; other site 646529010439 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 646529010440 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 646529010441 Domain of unknown function (DUF814); Region: DUF814; pfam05670 646529010442 Methyltransferase domain; Region: Methyltransf_31; pfam13847 646529010443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529010444 S-adenosylmethionine binding site [chemical binding]; other site 646529010445 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 646529010446 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 646529010447 active site 646529010448 catalytic tetrad [active] 646529010449 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 646529010450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529010451 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529010452 putative substrate translocation pore; other site 646529010453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 646529010454 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 646529010455 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 646529010456 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 646529010457 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 646529010458 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 646529010459 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 646529010460 amidase catalytic site [active] 646529010461 Zn binding residues [ion binding]; other site 646529010462 substrate binding site [chemical binding]; other site 646529010463 Uncharacterized conserved protein [Function unknown]; Region: COG3379 646529010464 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 646529010465 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 646529010466 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 646529010467 active site 646529010468 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 646529010469 active site 646529010470 dimer interface [polypeptide binding]; other site 646529010471 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 646529010472 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 646529010473 heterodimer interface [polypeptide binding]; other site 646529010474 active site 646529010475 FMN binding site [chemical binding]; other site 646529010476 homodimer interface [polypeptide binding]; other site 646529010477 substrate binding site [chemical binding]; other site 646529010478 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 646529010479 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 646529010480 FAD binding pocket [chemical binding]; other site 646529010481 FAD binding motif [chemical binding]; other site 646529010482 phosphate binding motif [ion binding]; other site 646529010483 beta-alpha-beta structure motif; other site 646529010484 NAD binding pocket [chemical binding]; other site 646529010485 Iron coordination center [ion binding]; other site 646529010486 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 646529010487 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 646529010488 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 646529010489 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 646529010490 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 646529010491 ATP-grasp domain; Region: ATP-grasp_4; cl17255 646529010492 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 646529010493 IMP binding site; other site 646529010494 dimer interface [polypeptide binding]; other site 646529010495 interdomain contacts; other site 646529010496 partial ornithine binding site; other site 646529010497 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 646529010498 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 646529010499 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 646529010500 catalytic site [active] 646529010501 subunit interface [polypeptide binding]; other site 646529010502 dihydroorotase; Validated; Region: pyrC; PRK09357 646529010503 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 646529010504 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 646529010505 active site 646529010506 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 646529010507 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 646529010508 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 646529010509 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 646529010510 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 646529010511 active site 646529010512 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 646529010513 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 646529010514 RNA binding surface [nucleotide binding]; other site 646529010515 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 646529010516 active site 646529010517 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 646529010518 lipoprotein signal peptidase; Provisional; Region: PRK14787 646529010519 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 646529010520 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 646529010521 Transposase domain (DUF772); Region: DUF772; pfam05598 646529010522 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 646529010523 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529010524 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 646529010525 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 646529010526 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 646529010527 Propanediol utilisation protein PduL; Region: PduL; pfam06130 646529010528 Propanediol utilisation protein PduL; Region: PduL; pfam06130 646529010529 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 646529010530 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 646529010531 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529010532 FeS/SAM binding site; other site 646529010533 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 646529010534 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529010535 FeS/SAM binding site; other site 646529010536 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 646529010537 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 646529010538 tetramer interface [polypeptide binding]; other site 646529010539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529010540 catalytic residue [active] 646529010541 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 646529010542 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 646529010543 tetramer interface [polypeptide binding]; other site 646529010544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529010545 catalytic residue [active] 646529010546 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 646529010547 lipoyl attachment site [posttranslational modification]; other site 646529010548 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 646529010549 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 646529010550 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 646529010551 DivIVA protein; Region: DivIVA; pfam05103 646529010552 DivIVA domain; Region: DivI1A_domain; TIGR03544 646529010553 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 646529010554 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 646529010555 RNA binding surface [nucleotide binding]; other site 646529010556 YGGT family; Region: YGGT; pfam02325 646529010557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 646529010558 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 646529010559 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 646529010560 catalytic residue [active] 646529010561 HlyD family secretion protein; Region: HlyD_2; pfam12700 646529010562 putative membrane fusion protein; Region: TIGR02828 646529010563 HAMP domain; Region: HAMP; pfam00672 646529010564 dimerization interface [polypeptide binding]; other site 646529010565 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 646529010566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529010567 dimer interface [polypeptide binding]; other site 646529010568 phosphorylation site [posttranslational modification] 646529010569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529010570 ATP binding site [chemical binding]; other site 646529010571 Mg2+ binding site [ion binding]; other site 646529010572 G-X-G motif; other site 646529010573 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529010574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529010575 active site 646529010576 phosphorylation site [posttranslational modification] 646529010577 intermolecular recognition site; other site 646529010578 dimerization interface [polypeptide binding]; other site 646529010579 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529010580 DNA binding site [nucleotide binding] 646529010581 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 646529010582 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 646529010583 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 646529010584 sporulation sigma factor SigG; Reviewed; Region: PRK08215 646529010585 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529010586 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 646529010587 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529010588 DNA binding residues [nucleotide binding] 646529010589 sporulation sigma factor SigE; Reviewed; Region: PRK08301 646529010590 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529010591 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529010592 DNA binding residues [nucleotide binding] 646529010593 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 646529010594 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 646529010595 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529010596 dimer interface [polypeptide binding]; other site 646529010597 putative CheW interface [polypeptide binding]; other site 646529010598 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 646529010599 cell division protein FtsZ; Validated; Region: PRK09330 646529010600 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 646529010601 nucleotide binding site [chemical binding]; other site 646529010602 SulA interaction site; other site 646529010603 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 646529010604 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 646529010605 Cell division protein FtsQ; Region: FtsQ; pfam03799 646529010606 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 646529010607 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 646529010608 hinge; other site 646529010609 active site 646529010610 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 646529010611 FAD binding domain; Region: FAD_binding_4; pfam01565 646529010612 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 646529010613 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 646529010614 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 646529010615 active site 646529010616 homodimer interface [polypeptide binding]; other site 646529010617 cell division protein FtsW; Region: ftsW; TIGR02614 646529010618 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 646529010619 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 646529010620 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 646529010621 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 646529010622 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 646529010623 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 646529010624 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 646529010625 Mg++ binding site [ion binding]; other site 646529010626 putative catalytic motif [active] 646529010627 putative substrate binding site [chemical binding]; other site 646529010628 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 646529010629 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 646529010630 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 646529010631 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 646529010632 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 646529010633 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 646529010634 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 646529010635 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 646529010636 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 646529010637 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 646529010638 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 646529010639 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 646529010640 MraW methylase family; Region: Methyltransf_5; pfam01795 646529010641 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 646529010642 cell division protein MraZ; Reviewed; Region: PRK00326 646529010643 MraZ protein; Region: MraZ; pfam02381 646529010644 MraZ protein; Region: MraZ; pfam02381 646529010645 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 646529010646 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 646529010647 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 646529010648 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 646529010649 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 646529010650 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 646529010651 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 646529010652 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 646529010653 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 646529010654 ferric uptake regulator; Provisional; Region: fur; PRK09462 646529010655 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 646529010656 metal binding site 2 [ion binding]; metal-binding site 646529010657 putative DNA binding helix; other site 646529010658 metal binding site 1 [ion binding]; metal-binding site 646529010659 dimer interface [polypeptide binding]; other site 646529010660 structural Zn2+ binding site [ion binding]; other site 646529010661 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 646529010662 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529010663 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 646529010664 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 646529010665 metal ion-dependent adhesion site (MIDAS); other site 646529010666 MoxR-like ATPases [General function prediction only]; Region: COG0714 646529010667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529010668 Walker A motif; other site 646529010669 ATP binding site [chemical binding]; other site 646529010670 Walker B motif; other site 646529010671 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 646529010672 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 646529010673 Protein of unknown function (DUF964); Region: DUF964; pfam06133 646529010674 histidinol-phosphatase; Provisional; Region: PRK07328 646529010675 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 646529010676 active site 646529010677 dimer interface [polypeptide binding]; other site 646529010678 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 646529010679 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 646529010680 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 646529010681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529010682 Coenzyme A binding pocket [chemical binding]; other site 646529010683 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 646529010684 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 646529010685 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 646529010686 Walker A motif; other site 646529010687 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 646529010688 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 646529010689 dimer interface [polypeptide binding]; other site 646529010690 putative functional site; other site 646529010691 putative MPT binding site; other site 646529010692 Protein of unknown function (DUF342); Region: DUF342; pfam03961 646529010693 Transcriptional regulator [Transcription]; Region: LytR; COG1316 646529010694 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 646529010695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 646529010696 selenophosphate synthetase; Provisional; Region: PRK00943 646529010697 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 646529010698 dimerization interface [polypeptide binding]; other site 646529010699 putative ATP binding site [chemical binding]; other site 646529010700 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 646529010701 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 646529010702 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 646529010703 catalytic residue [active] 646529010704 Negative regulator of genetic competence (MecA); Region: MecA; pfam05389 646529010705 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 646529010706 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 646529010707 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 646529010708 N-acetyl-D-glucosamine binding site [chemical binding]; other site 646529010709 catalytic residue [active] 646529010710 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 646529010711 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 646529010712 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 646529010713 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 646529010714 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 646529010715 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 646529010716 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 646529010717 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 646529010718 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 646529010719 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 646529010720 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 646529010721 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 646529010722 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 646529010723 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 646529010724 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 646529010725 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 646529010726 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529010727 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 646529010728 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529010729 DNA binding residues [nucleotide binding] 646529010730 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 646529010731 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 646529010732 CheC-like family; Region: CheC; pfam04509 646529010733 CheC-like family; Region: CheC; pfam04509 646529010734 Flagellar protein YcgR; Region: YcgR_2; pfam12945 646529010735 PilZ domain; Region: PilZ; pfam07238 646529010736 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 646529010737 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 646529010738 P-loop; other site 646529010739 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 646529010740 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 646529010741 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 646529010742 FHIPEP family; Region: FHIPEP; pfam00771 646529010743 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 646529010744 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 646529010745 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 646529010746 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 646529010747 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 646529010748 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 646529010749 Response regulator receiver domain; Region: Response_reg; pfam00072 646529010750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529010751 active site 646529010752 phosphorylation site [posttranslational modification] 646529010753 intermolecular recognition site; other site 646529010754 dimerization interface [polypeptide binding]; other site 646529010755 flagellar motor switch protein; Validated; Region: PRK08119 646529010756 CheC-like family; Region: CheC; pfam04509 646529010757 flagellar motor switch protein FliN; Region: fliN; TIGR02480 646529010758 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 646529010759 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 646529010760 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 646529010761 Flagellar protein (FlbD); Region: FlbD; pfam06289 646529010762 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 646529010763 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 646529010764 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 646529010765 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 646529010766 Walker A motif/ATP binding site; other site 646529010767 Walker B motif; other site 646529010768 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 646529010769 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 646529010770 Flagellar assembly protein FliH; Region: FliH; pfam02108 646529010771 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 646529010772 MgtE intracellular N domain; Region: MgtE_N; cl15244 646529010773 FliG C-terminal domain; Region: FliG_C; pfam01706 646529010774 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 646529010775 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 646529010776 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 646529010777 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 646529010778 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 646529010779 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 646529010780 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 646529010781 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 646529010782 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 646529010783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529010784 active site 646529010785 phosphorylation site [posttranslational modification] 646529010786 intermolecular recognition site; other site 646529010787 dimerization interface [polypeptide binding]; other site 646529010788 CheB methylesterase; Region: CheB_methylest; pfam01339 646529010789 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 646529010790 putative CheA interaction surface; other site 646529010791 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 646529010792 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 646529010793 putative binding surface; other site 646529010794 active site 646529010795 P2 response regulator binding domain; Region: P2; pfam07194 646529010796 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 646529010797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529010798 ATP binding site [chemical binding]; other site 646529010799 Mg2+ binding site [ion binding]; other site 646529010800 G-X-G motif; other site 646529010801 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 646529010802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 646529010803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 646529010804 Flagellar protein FliS; Region: FliS; cl00654 646529010805 pseudaminic acid synthase; Region: PseI; TIGR03586 646529010806 NeuB family; Region: NeuB; pfam03102 646529010807 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 646529010808 NeuB binding interface [polypeptide binding]; other site 646529010809 putative substrate binding site [chemical binding]; other site 646529010810 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 646529010811 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 646529010812 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 646529010813 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 646529010814 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 646529010815 ligand binding site; other site 646529010816 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 646529010817 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 646529010818 inhibitor-cofactor binding pocket; inhibition site 646529010819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529010820 catalytic residue [active] 646529010821 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 646529010822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 646529010823 NAD(P) binding site [chemical binding]; other site 646529010824 active site 646529010825 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 646529010826 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 646529010827 NAD(P) binding site [chemical binding]; other site 646529010828 homodimer interface [polypeptide binding]; other site 646529010829 substrate binding site [chemical binding]; other site 646529010830 active site 646529010831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 646529010832 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 646529010833 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 646529010834 FlaG protein; Region: FlaG; pfam03646 646529010835 flagellin; Provisional; Region: PRK12804 646529010836 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 646529010837 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 646529010838 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 646529010839 putative metal binding site; other site 646529010840 carbon storage regulator; Provisional; Region: PRK01712 646529010841 FliW protein; Region: FliW; cl00740 646529010842 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 646529010843 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 646529010844 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 646529010845 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 646529010846 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 646529010847 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 646529010848 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 646529010849 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 646529010850 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 646529010851 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 646529010852 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 646529010853 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 646529010854 ligand binding site [chemical binding]; other site 646529010855 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 646529010856 Peptidase family M28; Region: Peptidase_M28; pfam04389 646529010857 metal binding site [ion binding]; metal-binding site 646529010858 Protein of unknown function (DUF327); Region: DUF327; pfam03885 646529010859 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 646529010860 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 646529010861 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 646529010862 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 646529010863 NAD binding site [chemical binding]; other site 646529010864 Uncharacterized conserved protein [Function unknown]; Region: COG0327 646529010865 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 646529010866 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 646529010867 Family of unknown function (DUF633); Region: DUF633; pfam04816 646529010868 Uncharacterized conserved protein (DUF2290); Region: DUF2290; cl02396 646529010869 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 646529010870 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 646529010871 ATP binding site [chemical binding]; other site 646529010872 putative Mg++ binding site [ion binding]; other site 646529010873 Family description; Region: UvrD_C_2; pfam13538 646529010874 Superfamily II helicase [General function prediction only]; Region: COG1204 646529010875 DEAD/DEAH box helicase; Region: DEAD; pfam00270 646529010876 ATP binding site [chemical binding]; other site 646529010877 putative Mg++ binding site [ion binding]; other site 646529010878 nucleotide binding region [chemical binding]; other site 646529010879 helicase superfamily c-terminal domain; Region: HELICc; smart00490 646529010880 ATP-binding site [chemical binding]; other site 646529010881 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 646529010882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529010883 non-specific DNA binding site [nucleotide binding]; other site 646529010884 salt bridge; other site 646529010885 sequence-specific DNA binding site [nucleotide binding]; other site 646529010886 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 646529010887 Part of AAA domain; Region: AAA_19; pfam13245 646529010888 Family description; Region: UvrD_C_2; pfam13538 646529010889 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 646529010890 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 646529010891 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 646529010892 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 646529010893 active site 646529010894 metal binding site [ion binding]; metal-binding site 646529010895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529010896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529010897 dimer interface [polypeptide binding]; other site 646529010898 phosphorylation site [posttranslational modification] 646529010899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529010900 ATP binding site [chemical binding]; other site 646529010901 Mg2+ binding site [ion binding]; other site 646529010902 G-X-G motif; other site 646529010903 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 646529010904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529010905 active site 646529010906 phosphorylation site [posttranslational modification] 646529010907 intermolecular recognition site; other site 646529010908 dimerization interface [polypeptide binding]; other site 646529010909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529010910 Walker A motif; other site 646529010911 ATP binding site [chemical binding]; other site 646529010912 Walker B motif; other site 646529010913 arginine finger; other site 646529010914 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 646529010915 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 646529010916 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 646529010917 ResB-like family; Region: ResB; pfam05140 646529010918 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 646529010919 rusticyanin; Region: rusti_cyanin; TIGR03095 646529010920 Tetratricopeptide repeat; Region: TPR_12; pfam13424 646529010921 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529010922 TPR motif; other site 646529010923 binding surface 646529010924 TPR repeat; Region: TPR_11; pfam13414 646529010925 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 646529010926 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529010927 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 646529010928 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529010929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529010930 active site 646529010931 phosphorylation site [posttranslational modification] 646529010932 intermolecular recognition site; other site 646529010933 dimerization interface [polypeptide binding]; other site 646529010934 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529010935 DNA binding site [nucleotide binding] 646529010936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529010937 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529010938 dimerization interface [polypeptide binding]; other site 646529010939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529010940 dimer interface [polypeptide binding]; other site 646529010941 phosphorylation site [posttranslational modification] 646529010942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529010943 ATP binding site [chemical binding]; other site 646529010944 Mg2+ binding site [ion binding]; other site 646529010945 G-X-G motif; other site 646529010946 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529010947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529010948 metal binding site [ion binding]; metal-binding site 646529010949 active site 646529010950 I-site; other site 646529010951 Cache domain; Region: Cache_1; pfam02743 646529010952 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529010953 Zn2+ binding site [ion binding]; other site 646529010954 Mg2+ binding site [ion binding]; other site 646529010955 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 646529010956 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529010957 dimerization interface [polypeptide binding]; other site 646529010958 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 646529010959 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529010960 dimer interface [polypeptide binding]; other site 646529010961 putative CheW interface [polypeptide binding]; other site 646529010962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529010963 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 646529010964 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 646529010965 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 646529010966 dimerization interface [polypeptide binding]; other site 646529010967 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 646529010968 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 646529010969 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529010970 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529010971 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529010972 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 646529010973 metal-binding site [ion binding] 646529010974 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 646529010975 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 646529010976 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 646529010977 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 646529010978 AAA domain; Region: AAA_14; pfam13173 646529010979 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 646529010980 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 646529010981 active site 646529010982 metal binding site [ion binding]; metal-binding site 646529010983 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 646529010984 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 646529010985 active site 646529010986 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 646529010987 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 646529010988 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 646529010989 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529010990 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529010991 DNA binding residues [nucleotide binding] 646529010992 Putative zinc-finger; Region: zf-HC2; pfam13490 646529010993 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 646529010994 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 646529010995 Divergent PAP2 family; Region: DUF212; pfam02681 646529010996 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 646529010997 putative homodimer interface [polypeptide binding]; other site 646529010998 putative homotetramer interface [polypeptide binding]; other site 646529010999 allosteric switch controlling residues; other site 646529011000 putative metal binding site [ion binding]; other site 646529011001 putative homodimer-homodimer interface [polypeptide binding]; other site 646529011002 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 646529011003 metal-binding site [ion binding] 646529011004 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 646529011005 metal-binding site [ion binding] 646529011006 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 646529011007 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 646529011008 metal-binding site [ion binding] 646529011009 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 646529011010 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 646529011011 motif II; other site 646529011012 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 646529011013 metal-binding site [ion binding] 646529011014 Short C-terminal domain; Region: SHOCT; pfam09851 646529011015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529011016 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529011017 dimerization interface [polypeptide binding]; other site 646529011018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529011019 dimer interface [polypeptide binding]; other site 646529011020 phosphorylation site [posttranslational modification] 646529011021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529011022 ATP binding site [chemical binding]; other site 646529011023 Mg2+ binding site [ion binding]; other site 646529011024 G-X-G motif; other site 646529011025 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529011026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529011027 active site 646529011028 phosphorylation site [posttranslational modification] 646529011029 intermolecular recognition site; other site 646529011030 dimerization interface [polypeptide binding]; other site 646529011031 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529011032 DNA binding site [nucleotide binding] 646529011033 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 646529011034 dimerization interface [polypeptide binding]; other site 646529011035 putative DNA binding site [nucleotide binding]; other site 646529011036 putative Zn2+ binding site [ion binding]; other site 646529011037 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 646529011038 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 646529011039 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 646529011040 Short C-terminal domain; Region: SHOCT; pfam09851 646529011041 Predicted membrane protein [Function unknown]; Region: COG3462 646529011042 Short C-terminal domain; Region: SHOCT; pfam09851 646529011043 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 646529011044 active site residue [active] 646529011045 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 646529011046 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 646529011047 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 646529011048 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 646529011049 DNA binding residues [nucleotide binding] 646529011050 dimer interface [polypeptide binding]; other site 646529011051 Iron permease FTR1 family; Region: FTR1; cl00475 646529011052 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 646529011053 MarR family; Region: MarR_2; cl17246 646529011054 MarR family; Region: MarR_2; cl17246 646529011055 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 646529011056 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 646529011057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 646529011058 motif II; other site 646529011059 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 646529011060 Helix-turn-helix domain; Region: HTH_17; pfam12728 646529011061 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 646529011062 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 646529011063 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 646529011064 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529011065 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 646529011066 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529011067 DNA binding residues [nucleotide binding] 646529011068 DNA primase; Validated; Region: dnaG; PRK05667 646529011069 CHC2 zinc finger; Region: zf-CHC2; pfam01807 646529011070 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 646529011071 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 646529011072 active site 646529011073 metal binding site [ion binding]; metal-binding site 646529011074 interdomain interaction site; other site 646529011075 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 646529011076 Sporulation and spore germination; Region: Germane; pfam10646 646529011077 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 646529011078 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529011079 Zn2+ binding site [ion binding]; other site 646529011080 Mg2+ binding site [ion binding]; other site 646529011081 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 646529011082 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529011083 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529011084 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529011085 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 646529011086 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 646529011087 active site 646529011088 multimer interface [polypeptide binding]; other site 646529011089 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 646529011090 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 646529011091 substrate binding site [chemical binding]; other site 646529011092 tetramer interface [polypeptide binding]; other site 646529011093 catalytic residue [active] 646529011094 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 646529011095 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 646529011096 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 646529011097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529011098 putative active site [active] 646529011099 heme pocket [chemical binding]; other site 646529011100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529011101 Walker A motif; other site 646529011102 ATP binding site [chemical binding]; other site 646529011103 Walker B motif; other site 646529011104 arginine finger; other site 646529011105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529011106 dimerization interface [polypeptide binding]; other site 646529011107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529011108 dimer interface [polypeptide binding]; other site 646529011109 phosphorylation site [posttranslational modification] 646529011110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529011111 ATP binding site [chemical binding]; other site 646529011112 Mg2+ binding site [ion binding]; other site 646529011113 G-X-G motif; other site 646529011114 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529011115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529011116 active site 646529011117 phosphorylation site [posttranslational modification] 646529011118 intermolecular recognition site; other site 646529011119 dimerization interface [polypeptide binding]; other site 646529011120 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529011121 DNA binding site [nucleotide binding] 646529011122 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 646529011123 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 646529011124 catalytic residues [active] 646529011125 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 646529011126 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 646529011127 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 646529011128 sensory histidine kinase DcuS; Provisional; Region: PRK11086 646529011129 PAS domain; Region: PAS; smart00091 646529011130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529011131 ATP binding site [chemical binding]; other site 646529011132 Mg2+ binding site [ion binding]; other site 646529011133 G-X-G motif; other site 646529011134 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 646529011135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529011136 active site 646529011137 phosphorylation site [posttranslational modification] 646529011138 intermolecular recognition site; other site 646529011139 dimerization interface [polypeptide binding]; other site 646529011140 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 646529011141 Malic enzyme, N-terminal domain; Region: malic; pfam00390 646529011142 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 646529011143 putative NAD(P) binding site [chemical binding]; other site 646529011144 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 646529011145 pyruvate phosphate dikinase; Provisional; Region: PRK09279 646529011146 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 646529011147 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 646529011148 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 646529011149 PEP synthetase regulatory protein; Provisional; Region: PRK05339 646529011150 HTH domain; Region: HTH_11; pfam08279 646529011151 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 646529011152 FOG: CBS domain [General function prediction only]; Region: COG0517 646529011153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529011154 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 646529011155 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529011156 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 646529011157 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 646529011158 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 646529011159 dimer interface [polypeptide binding]; other site 646529011160 motif 1; other site 646529011161 active site 646529011162 motif 2; other site 646529011163 motif 3; other site 646529011164 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 646529011165 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 646529011166 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 646529011167 Recombination protein O N terminal; Region: RecO_N; pfam11967 646529011168 Recombination protein O C terminal; Region: RecO_C; pfam02565 646529011169 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 646529011170 intersubunit interface [polypeptide binding]; other site 646529011171 active site 646529011172 catalytic residue [active] 646529011173 GTPase Era; Reviewed; Region: era; PRK00089 646529011174 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 646529011175 G1 box; other site 646529011176 GTP/Mg2+ binding site [chemical binding]; other site 646529011177 Switch I region; other site 646529011178 G2 box; other site 646529011179 Switch II region; other site 646529011180 G3 box; other site 646529011181 G4 box; other site 646529011182 G5 box; other site 646529011183 KH domain; Region: KH_2; pfam07650 646529011184 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 646529011185 active site 646529011186 catalytic motif [active] 646529011187 Zn binding site [ion binding]; other site 646529011188 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 646529011189 metal-binding heat shock protein; Provisional; Region: PRK00016 646529011190 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 646529011191 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 646529011192 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529011193 Zn2+ binding site [ion binding]; other site 646529011194 Mg2+ binding site [ion binding]; other site 646529011195 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 646529011196 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 646529011197 YabP family; Region: YabP; cl06766 646529011198 Yqey-like protein; Region: YqeY; pfam09424 646529011199 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 646529011200 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 646529011201 nucleotide binding site/active site [active] 646529011202 HIT family signature motif; other site 646529011203 catalytic residue [active] 646529011204 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 646529011205 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 646529011206 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529011207 FeS/SAM binding site; other site 646529011208 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 646529011209 RNA methyltransferase, RsmE family; Region: TIGR00046 646529011210 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 646529011211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 646529011212 chaperone protein DnaJ; Provisional; Region: PRK10767 646529011213 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 646529011214 HSP70 interaction site [polypeptide binding]; other site 646529011215 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 646529011216 substrate binding site [polypeptide binding]; other site 646529011217 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 646529011218 Zn binding sites [ion binding]; other site 646529011219 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 646529011220 dimer interface [polypeptide binding]; other site 646529011221 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 646529011222 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 646529011223 nucleotide binding site [chemical binding]; other site 646529011224 NEF interaction site [polypeptide binding]; other site 646529011225 SBD interface [polypeptide binding]; other site 646529011226 GrpE; Region: GrpE; pfam01025 646529011227 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 646529011228 dimer interface [polypeptide binding]; other site 646529011229 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 646529011230 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 646529011231 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 646529011232 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 646529011233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529011234 FeS/SAM binding site; other site 646529011235 HemN C-terminal domain; Region: HemN_C; pfam06969 646529011236 GTP-binding protein LepA; Provisional; Region: PRK05433 646529011237 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 646529011238 G1 box; other site 646529011239 putative GEF interaction site [polypeptide binding]; other site 646529011240 GTP/Mg2+ binding site [chemical binding]; other site 646529011241 Switch I region; other site 646529011242 G2 box; other site 646529011243 G3 box; other site 646529011244 Switch II region; other site 646529011245 G4 box; other site 646529011246 G5 box; other site 646529011247 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 646529011248 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 646529011249 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 646529011250 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 646529011251 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 646529011252 catalytic loop [active] 646529011253 iron binding site [ion binding]; other site 646529011254 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 646529011255 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529011256 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529011257 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 646529011258 molybdenum transport protein ModD; Provisional; Region: PRK06096 646529011259 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 646529011260 dimerization interface [polypeptide binding]; other site 646529011261 active site 646529011262 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 646529011263 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 646529011264 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 646529011265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529011266 Walker A/P-loop; other site 646529011267 ATP binding site [chemical binding]; other site 646529011268 Q-loop/lid; other site 646529011269 ABC transporter signature motif; other site 646529011270 Walker B; other site 646529011271 D-loop; other site 646529011272 H-loop/switch region; other site 646529011273 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 646529011274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529011275 dimer interface [polypeptide binding]; other site 646529011276 conserved gate region; other site 646529011277 putative PBP binding loops; other site 646529011278 ABC-ATPase subunit interface; other site 646529011279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529011280 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 646529011281 Walker A/P-loop; other site 646529011282 ATP binding site [chemical binding]; other site 646529011283 Q-loop/lid; other site 646529011284 ABC transporter signature motif; other site 646529011285 Walker B; other site 646529011286 D-loop; other site 646529011287 H-loop/switch region; other site 646529011288 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 646529011289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529011290 dimer interface [polypeptide binding]; other site 646529011291 conserved gate region; other site 646529011292 putative PBP binding loops; other site 646529011293 ABC-ATPase subunit interface; other site 646529011294 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 646529011295 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 646529011296 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 646529011297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 646529011298 Coenzyme A binding pocket [chemical binding]; other site 646529011299 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 646529011300 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 646529011301 active site 646529011302 catalytic residues [active] 646529011303 metal binding site [ion binding]; metal-binding site 646529011304 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529011305 Radical SAM superfamily; Region: Radical_SAM; pfam04055 646529011306 FeS/SAM binding site; other site 646529011307 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 646529011308 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 646529011309 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 646529011310 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 646529011311 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 646529011312 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 646529011313 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 646529011314 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 646529011315 MoFe protein beta/alpha subunit interactions; other site 646529011316 Beta subunit P cluster binding residues; other site 646529011317 MoFe protein beta subunit/Fe protein contacts; other site 646529011318 MoFe protein dimer/ dimer interactions; other site 646529011319 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 646529011320 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 646529011321 MoFe protein alpha/beta subunit interactions; other site 646529011322 Alpha subunit P cluster binding residues; other site 646529011323 FeMoco binding residues [chemical binding]; other site 646529011324 MoFe protein alpha subunit/Fe protein contacts; other site 646529011325 MoFe protein dimer/ dimer interactions; other site 646529011326 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 646529011327 nitrogenase iron protein; Region: nifH; TIGR01287 646529011328 Nucleotide-binding sites [chemical binding]; other site 646529011329 Walker A motif; other site 646529011330 Switch I region of nucleotide binding site; other site 646529011331 Fe4S4 binding sites [ion binding]; other site 646529011332 Switch II region of nucleotide binding site; other site 646529011333 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 646529011334 Nitrogen regulatory protein P-II; Region: P-II; smart00938 646529011335 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 646529011336 Nitrogen regulatory protein P-II; Region: P-II; smart00938 646529011337 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 646529011338 hexamer interface [polypeptide binding]; other site 646529011339 RNA binding site [nucleotide binding]; other site 646529011340 Histidine-zinc binding site [chemical binding]; other site 646529011341 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 646529011342 MviN-like protein; Region: MVIN; pfam03023 646529011343 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 646529011344 stage II sporulation protein P; Region: spore_II_P; TIGR02867 646529011345 Membrane protein of unknown function; Region: DUF360; pfam04020 646529011346 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 646529011347 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 646529011348 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 646529011349 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 646529011350 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 646529011351 Competence protein; Region: Competence; pfam03772 646529011352 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 646529011353 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 646529011354 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 646529011355 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 646529011356 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 646529011357 putative active site [active] 646529011358 PhoH-like protein; Region: PhoH; pfam02562 646529011359 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 646529011360 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 646529011361 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 646529011362 HIGH motif; other site 646529011363 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 646529011364 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 646529011365 active site 646529011366 KMSKS motif; other site 646529011367 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 646529011368 tRNA binding surface [nucleotide binding]; other site 646529011369 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 646529011370 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529011371 Zn2+ binding site [ion binding]; other site 646529011372 Mg2+ binding site [ion binding]; other site 646529011373 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 646529011374 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 646529011375 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 646529011376 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 646529011377 active site 646529011378 (T/H)XGH motif; other site 646529011379 multiple promoter invertase; Provisional; Region: mpi; PRK13413 646529011380 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 646529011381 catalytic residues [active] 646529011382 catalytic nucleophile [active] 646529011383 Presynaptic Site I dimer interface [polypeptide binding]; other site 646529011384 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 646529011385 Synaptic Flat tetramer interface [polypeptide binding]; other site 646529011386 Synaptic Site I dimer interface [polypeptide binding]; other site 646529011387 DNA binding site [nucleotide binding] 646529011388 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 646529011389 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529011390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529011391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529011392 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529011393 Orotate phosphoribosyltransferase homologs [Nucleotide transport and metabolism]; Region: COG0856 646529011394 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 646529011395 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 646529011396 Domain of unknown function DUF87; Region: DUF87; pfam01935 646529011397 AAA-like domain; Region: AAA_10; pfam12846 646529011398 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 646529011399 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 646529011400 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529011401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529011402 metal binding site [ion binding]; metal-binding site 646529011403 active site 646529011404 I-site; other site 646529011405 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 646529011406 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 646529011407 Ligand binding site; other site 646529011408 Putative Catalytic site; other site 646529011409 DXD motif; other site 646529011410 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 646529011411 Walker B motif; other site 646529011412 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 646529011413 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 646529011414 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 646529011415 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 646529011416 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 646529011417 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 646529011418 active site 646529011419 DNA binding site [nucleotide binding] 646529011420 Int/Topo IB signature motif; other site 646529011421 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 646529011422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529011423 non-specific DNA binding site [nucleotide binding]; other site 646529011424 salt bridge; other site 646529011425 sequence-specific DNA binding site [nucleotide binding]; other site 646529011426 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 646529011427 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 646529011428 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 646529011429 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 646529011430 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 646529011431 Walker A motif; other site 646529011432 ATP binding site [chemical binding]; other site 646529011433 Walker B motif; other site 646529011434 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 646529011435 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 646529011436 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529011437 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529011438 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529011439 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 646529011440 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 646529011441 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 646529011442 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 646529011443 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 646529011444 putative active site [active] 646529011445 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 646529011446 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 646529011447 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 646529011448 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 646529011449 active site 646529011450 DNA binding site [nucleotide binding] 646529011451 Int/Topo IB signature motif; other site 646529011452 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 646529011453 bacterial Hfq-like; Region: Hfq; cd01716 646529011454 hexamer interface [polypeptide binding]; other site 646529011455 Sm1 motif; other site 646529011456 RNA binding site [nucleotide binding]; other site 646529011457 Sm2 motif; other site 646529011458 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 646529011459 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 646529011460 alphaNTD - beta interaction site [polypeptide binding]; other site 646529011461 alphaNTD homodimer interface [polypeptide binding]; other site 646529011462 alphaNTD - beta' interaction site [polypeptide binding]; other site 646529011463 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 646529011464 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 646529011465 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 646529011466 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 646529011467 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 646529011468 5'-3' exonuclease; Region: 53EXOc; smart00475 646529011469 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 646529011470 active site 646529011471 metal binding site 1 [ion binding]; metal-binding site 646529011472 putative 5' ssDNA interaction site; other site 646529011473 metal binding site 3; metal-binding site 646529011474 metal binding site 2 [ion binding]; metal-binding site 646529011475 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 646529011476 putative DNA binding site [nucleotide binding]; other site 646529011477 putative metal binding site [ion binding]; other site 646529011478 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 646529011479 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529011480 DNA binding residues [nucleotide binding] 646529011481 plasmid segregation protein ParM; Provisional; Region: PRK13917 646529011482 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 646529011483 Mg binding site [ion binding]; other site 646529011484 nucleotide binding site [chemical binding]; other site 646529011485 putative protofilament interface [polypeptide binding]; other site 646529011486 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 646529011487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529011488 non-specific DNA binding site [nucleotide binding]; other site 646529011489 salt bridge; other site 646529011490 sequence-specific DNA binding site [nucleotide binding]; other site 646529011491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529011492 sequence-specific DNA binding site [nucleotide binding]; other site 646529011493 salt bridge; other site 646529011494 Domain of unknown function (DUF955); Region: DUF955; pfam06114 646529011495 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 646529011496 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 646529011497 catalytic residues [active] 646529011498 catalytic nucleophile [active] 646529011499 Recombinase; Region: Recombinase; pfam07508 646529011500 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 646529011501 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 646529011502 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 646529011503 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 646529011504 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 646529011505 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 646529011506 dimerization domain swap beta strand [polypeptide binding]; other site 646529011507 regulatory protein interface [polypeptide binding]; other site 646529011508 active site 646529011509 regulatory phosphorylation site [posttranslational modification]; other site 646529011510 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 646529011511 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 646529011512 active site 646529011513 P-loop; other site 646529011514 phosphorylation site [posttranslational modification] 646529011515 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 646529011516 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 646529011517 active site 646529011518 phosphorylation site [posttranslational modification] 646529011519 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 646529011520 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 646529011521 putative substrate binding site [chemical binding]; other site 646529011522 putative ATP binding site [chemical binding]; other site 646529011523 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 646529011524 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 646529011525 putative DNA binding site [nucleotide binding]; other site 646529011526 putative Zn2+ binding site [ion binding]; other site 646529011527 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 646529011528 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 646529011529 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 646529011530 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 646529011531 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 646529011532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 646529011533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 646529011534 Isochorismatase family; Region: Isochorismatase; pfam00857 646529011535 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 646529011536 catalytic triad [active] 646529011537 conserved cis-peptide bond; other site 646529011538 drug efflux system protein MdtG; Provisional; Region: PRK09874 646529011539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529011540 putative substrate translocation pore; other site 646529011541 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 646529011542 Transglycosylase; Region: Transgly; pfam00912 646529011543 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 646529011544 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 646529011545 UDP-galactopyranose mutase; Region: GLF; pfam03275 646529011546 putative glycosyl transferase; Provisional; Region: PRK10073 646529011547 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 646529011548 active site 646529011549 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 646529011550 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 646529011551 active site 646529011552 Predicted membrane protein [Function unknown]; Region: COG4280 646529011553 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 646529011554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529011555 Walker A/P-loop; other site 646529011556 ATP binding site [chemical binding]; other site 646529011557 Q-loop/lid; other site 646529011558 ABC transporter signature motif; other site 646529011559 Walker B; other site 646529011560 D-loop; other site 646529011561 H-loop/switch region; other site 646529011562 TOBE domain; Region: TOBE_2; pfam08402 646529011563 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 646529011564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529011565 dimer interface [polypeptide binding]; other site 646529011566 conserved gate region; other site 646529011567 putative PBP binding loops; other site 646529011568 ABC-ATPase subunit interface; other site 646529011569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529011570 dimer interface [polypeptide binding]; other site 646529011571 conserved gate region; other site 646529011572 putative PBP binding loops; other site 646529011573 ABC-ATPase subunit interface; other site 646529011574 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 646529011575 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 646529011576 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529011577 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529011578 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529011579 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 646529011580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529011581 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529011582 putative substrate translocation pore; other site 646529011583 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529011584 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 646529011585 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 646529011586 active site 646529011587 dimer interface [polypeptide binding]; other site 646529011588 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 646529011589 Ligand Binding Site [chemical binding]; other site 646529011590 Molecular Tunnel; other site 646529011591 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 646529011592 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 646529011593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529011594 S-adenosylmethionine binding site [chemical binding]; other site 646529011595 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 646529011596 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 646529011597 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 646529011598 active site 646529011599 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 646529011600 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 646529011601 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 646529011602 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 646529011603 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 646529011604 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 646529011605 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 646529011606 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 646529011607 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 646529011608 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 646529011609 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 646529011610 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 646529011611 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 646529011612 FAD binding domain; Region: FAD_binding_4; pfam01565 646529011613 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 646529011614 short chain dehydrogenase; Provisional; Region: PRK07102 646529011615 NAD(P) binding site [chemical binding]; other site 646529011616 active site 646529011617 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 646529011618 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 646529011619 HlyD family secretion protein; Region: HlyD_3; pfam13437 646529011620 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 646529011621 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 646529011622 Walker A/P-loop; other site 646529011623 ATP binding site [chemical binding]; other site 646529011624 Q-loop/lid; other site 646529011625 ABC transporter signature motif; other site 646529011626 Walker B; other site 646529011627 D-loop; other site 646529011628 H-loop/switch region; other site 646529011629 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 646529011630 FtsX-like permease family; Region: FtsX; pfam02687 646529011631 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 646529011632 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 646529011633 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 646529011634 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 646529011635 Walker A/P-loop; other site 646529011636 ATP binding site [chemical binding]; other site 646529011637 Q-loop/lid; other site 646529011638 ABC transporter signature motif; other site 646529011639 Walker B; other site 646529011640 D-loop; other site 646529011641 H-loop/switch region; other site 646529011642 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 646529011643 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 646529011644 Walker A/P-loop; other site 646529011645 ATP binding site [chemical binding]; other site 646529011646 Q-loop/lid; other site 646529011647 ABC transporter signature motif; other site 646529011648 Walker B; other site 646529011649 D-loop; other site 646529011650 H-loop/switch region; other site 646529011651 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529011652 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529011653 dimerization interface [polypeptide binding]; other site 646529011654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529011655 dimer interface [polypeptide binding]; other site 646529011656 phosphorylation site [posttranslational modification] 646529011657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529011658 ATP binding site [chemical binding]; other site 646529011659 Mg2+ binding site [ion binding]; other site 646529011660 G-X-G motif; other site 646529011661 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529011662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529011663 active site 646529011664 phosphorylation site [posttranslational modification] 646529011665 intermolecular recognition site; other site 646529011666 dimerization interface [polypeptide binding]; other site 646529011667 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529011668 DNA binding site [nucleotide binding] 646529011669 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 646529011670 Predicted periplasmic protein [Function unknown]; Region: COG3698 646529011671 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 646529011672 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 646529011673 FtsX-like permease family; Region: FtsX; pfam02687 646529011674 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 646529011675 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 646529011676 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 646529011677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529011678 Walker A/P-loop; other site 646529011679 ATP binding site [chemical binding]; other site 646529011680 Q-loop/lid; other site 646529011681 ABC transporter signature motif; other site 646529011682 Walker B; other site 646529011683 D-loop; other site 646529011684 H-loop/switch region; other site 646529011685 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 646529011686 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 646529011687 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 646529011688 active site 646529011689 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 646529011690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529011691 dimerization interface [polypeptide binding]; other site 646529011692 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 646529011693 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529011694 dimer interface [polypeptide binding]; other site 646529011695 putative CheW interface [polypeptide binding]; other site 646529011696 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529011697 dimerization interface [polypeptide binding]; other site 646529011698 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 646529011699 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529011700 dimer interface [polypeptide binding]; other site 646529011701 putative CheW interface [polypeptide binding]; other site 646529011702 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 646529011703 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 646529011704 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 646529011705 ABC transporter; Region: ABC_tran_2; pfam12848 646529011706 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 646529011707 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 646529011708 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529011709 Walker A/P-loop; other site 646529011710 ATP binding site [chemical binding]; other site 646529011711 Q-loop/lid; other site 646529011712 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 646529011713 ABC transporter signature motif; other site 646529011714 Walker B; other site 646529011715 ABC transporter; Region: ABC_tran_2; pfam12848 646529011716 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 646529011717 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 646529011718 GEMM cis-regulatory element 646529011719 Putative motility protein; Region: YjfB_motility; pfam14070 646529011720 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 646529011721 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 646529011722 active site 646529011723 metal binding site [ion binding]; metal-binding site 646529011724 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 646529011725 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 646529011726 putative active site [active] 646529011727 putative metal binding site [ion binding]; other site 646529011728 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 646529011729 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 646529011730 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 646529011731 Probable zinc-binding domain; Region: zf-trcl; pfam13451 646529011732 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 646529011733 imidazolonepropionase; Validated; Region: PRK09356 646529011734 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 646529011735 active site 646529011736 glutamate formiminotransferase; Region: FtcD; TIGR02024 646529011737 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 646529011738 Formiminotransferase domain; Region: FTCD; pfam02971 646529011739 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 646529011740 urocanate hydratase; Provisional; Region: PRK05414 646529011741 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 646529011742 active site 646529011743 catalytic triad [active] 646529011744 oxyanion hole [active] 646529011745 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 646529011746 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 646529011747 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 646529011748 FtsX-like permease family; Region: FtsX; pfam02687 646529011749 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 646529011750 GTPase CgtA; Reviewed; Region: obgE; PRK12297 646529011751 GTP1/OBG; Region: GTP1_OBG; pfam01018 646529011752 Obg GTPase; Region: Obg; cd01898 646529011753 G1 box; other site 646529011754 GTP/Mg2+ binding site [chemical binding]; other site 646529011755 Switch I region; other site 646529011756 G2 box; other site 646529011757 G3 box; other site 646529011758 Switch II region; other site 646529011759 G4 box; other site 646529011760 G5 box; other site 646529011761 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 646529011762 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 646529011763 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 646529011764 Protein of unknown function (DUF464); Region: DUF464; pfam04327 646529011765 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 646529011766 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 646529011767 Transcriptional regulators [Transcription]; Region: MarR; COG1846 646529011768 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 646529011769 putative Zn2+ binding site [ion binding]; other site 646529011770 putative DNA binding site [nucleotide binding]; other site 646529011771 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 646529011772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529011773 putative substrate translocation pore; other site 646529011774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529011775 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 646529011776 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 646529011777 HlyD family secretion protein; Region: HlyD_3; pfam13437 646529011778 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 646529011779 HlyD family secretion protein; Region: HlyD_3; pfam13437 646529011780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529011781 non-specific DNA binding site [nucleotide binding]; other site 646529011782 salt bridge; other site 646529011783 sequence-specific DNA binding site [nucleotide binding]; other site 646529011784 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 646529011785 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 646529011786 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 646529011787 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 646529011788 DNA binding residues [nucleotide binding] 646529011789 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 646529011790 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 646529011791 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 646529011792 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 646529011793 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 646529011794 active site residue [active] 646529011795 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 646529011796 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 646529011797 active site 646529011798 NTP binding site [chemical binding]; other site 646529011799 metal binding triad [ion binding]; metal-binding site 646529011800 antibiotic binding site [chemical binding]; other site 646529011801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529011802 non-specific DNA binding site [nucleotide binding]; other site 646529011803 salt bridge; other site 646529011804 sequence-specific DNA binding site [nucleotide binding]; other site 646529011805 GEMM cis-regulatory element 646529011806 Protein of unknown function DUF86; Region: DUF86; pfam01934 646529011807 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 646529011808 active site 646529011809 NTP binding site [chemical binding]; other site 646529011810 metal binding triad [ion binding]; metal-binding site 646529011811 antibiotic binding site [chemical binding]; other site 646529011812 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 646529011813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529011814 non-specific DNA binding site [nucleotide binding]; other site 646529011815 salt bridge; other site 646529011816 sequence-specific DNA binding site [nucleotide binding]; other site 646529011817 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 646529011818 DNA protecting protein DprA; Region: dprA; TIGR00732 646529011819 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 646529011820 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 646529011821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529011822 Walker A motif; other site 646529011823 ATP binding site [chemical binding]; other site 646529011824 Walker B motif; other site 646529011825 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 646529011826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 646529011827 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 646529011828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 646529011829 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 646529011830 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 646529011831 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 646529011832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 646529011833 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 646529011834 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 646529011835 G1 box; other site 646529011836 GTP/Mg2+ binding site [chemical binding]; other site 646529011837 G2 box; other site 646529011838 Switch I region; other site 646529011839 G3 box; other site 646529011840 Switch II region; other site 646529011841 G4 box; other site 646529011842 G5 box; other site 646529011843 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 646529011844 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 646529011845 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 646529011846 ligand-binding site [chemical binding]; other site 646529011847 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 646529011848 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 646529011849 active site 646529011850 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 646529011851 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 646529011852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 646529011853 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 646529011854 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 646529011855 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 646529011856 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 646529011857 active site 646529011858 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 646529011859 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 646529011860 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 646529011861 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 646529011862 Probable Catalytic site; other site 646529011863 metal-binding site 646529011864 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 646529011865 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 646529011866 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 646529011867 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 646529011868 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 646529011869 NADP binding site [chemical binding]; other site 646529011870 active site 646529011871 putative substrate binding site [chemical binding]; other site 646529011872 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 646529011873 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 646529011874 NAD binding site [chemical binding]; other site 646529011875 substrate binding site [chemical binding]; other site 646529011876 homodimer interface [polypeptide binding]; other site 646529011877 active site 646529011878 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 646529011879 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 646529011880 substrate binding site; other site 646529011881 tetramer interface; other site 646529011882 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 646529011883 Bacterial sugar transferase; Region: Bac_transf; pfam02397 646529011884 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 646529011885 active site 646529011886 Bacterial sugar transferase; Region: Bac_transf; cl00939 646529011887 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 646529011888 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 646529011889 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 646529011890 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 646529011891 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 646529011892 Chain length determinant protein; Region: Wzz; cl15801 646529011893 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529011894 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529011895 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529011896 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529011897 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529011898 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529011899 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 646529011900 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 646529011901 homodimer interface [polypeptide binding]; other site 646529011902 oligonucleotide binding site [chemical binding]; other site 646529011903 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 646529011904 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 646529011905 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 646529011906 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 646529011907 B12 binding site [chemical binding]; other site 646529011908 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529011909 FeS/SAM binding site; other site 646529011910 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 646529011911 Peptidase family M50; Region: Peptidase_M50; pfam02163 646529011912 active site 646529011913 putative substrate binding region [chemical binding]; other site 646529011914 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 646529011915 Peptidase family M23; Region: Peptidase_M23; pfam01551 646529011916 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 646529011917 Septum formation topological specificity factor MinE; Region: MinE; cl00538 646529011918 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 646529011919 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 646529011920 Switch I; other site 646529011921 Switch II; other site 646529011922 septum formation inhibitor; Reviewed; Region: minC; PRK00513 646529011923 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 646529011924 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 646529011925 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 646529011926 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 646529011927 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 646529011928 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 646529011929 rod shape-determining protein MreC; Provisional; Region: PRK13922 646529011930 rod shape-determining protein MreC; Region: MreC; pfam04085 646529011931 rod shape-determining protein MreB; Provisional; Region: PRK13927 646529011932 MreB and similar proteins; Region: MreB_like; cd10225 646529011933 nucleotide binding site [chemical binding]; other site 646529011934 Mg binding site [ion binding]; other site 646529011935 putative protofilament interaction site [polypeptide binding]; other site 646529011936 RodZ interaction site [polypeptide binding]; other site 646529011937 DNA repair protein radc; Region: radc; TIGR00608 646529011938 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 646529011939 MPN+ (JAMM) motif; other site 646529011940 Zinc-binding site [ion binding]; other site 646529011941 Maf-like protein; Region: Maf; pfam02545 646529011942 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 646529011943 active site 646529011944 dimer interface [polypeptide binding]; other site 646529011945 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 646529011946 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 646529011947 Aspartase; Region: Aspartase; cd01357 646529011948 active sites [active] 646529011949 tetramer interface [polypeptide binding]; other site 646529011950 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 646529011951 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 646529011952 active site 1 [active] 646529011953 dimer interface [polypeptide binding]; other site 646529011954 hexamer interface [polypeptide binding]; other site 646529011955 active site 2 [active] 646529011956 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 646529011957 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 646529011958 active site 646529011959 catalytic residues [active] 646529011960 metal binding site [ion binding]; metal-binding site 646529011961 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 646529011962 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 646529011963 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 646529011964 CoA binding domain; Region: CoA_binding; smart00881 646529011965 Sporulation related domain; Region: SPOR; pfam05036 646529011966 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 646529011967 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 646529011968 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 646529011969 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 646529011970 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 646529011971 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 646529011972 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 646529011973 HIGH motif; other site 646529011974 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 646529011975 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 646529011976 active site 646529011977 KMSKS motif; other site 646529011978 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 646529011979 tRNA binding surface [nucleotide binding]; other site 646529011980 anticodon binding site; other site 646529011981 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 646529011982 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 646529011983 active site 646529011984 FMN binding site [chemical binding]; other site 646529011985 substrate binding site [chemical binding]; other site 646529011986 3Fe-4S cluster binding site [ion binding]; other site 646529011987 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 646529011988 putative FMN binding site [chemical binding]; other site 646529011989 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 646529011990 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 646529011991 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 646529011992 Uncharacterized conserved protein [Function unknown]; Region: COG1633 646529011993 dinuclear metal binding motif [ion binding]; other site 646529011994 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 646529011995 EamA-like transporter family; Region: EamA; pfam00892 646529011996 EamA-like transporter family; Region: EamA; pfam00892 646529011997 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 646529011998 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 646529011999 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 646529012000 G1 box; other site 646529012001 GTP/Mg2+ binding site [chemical binding]; other site 646529012002 Switch I region; other site 646529012003 G2 box; other site 646529012004 G3 box; other site 646529012005 Switch II region; other site 646529012006 G4 box; other site 646529012007 G5 box; other site 646529012008 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 646529012009 Found in ATP-dependent protease La (LON); Region: LON; smart00464 646529012010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529012011 Walker A motif; other site 646529012012 ATP binding site [chemical binding]; other site 646529012013 Walker B motif; other site 646529012014 arginine finger; other site 646529012015 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 646529012016 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 646529012017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529012018 Walker A motif; other site 646529012019 ATP binding site [chemical binding]; other site 646529012020 Walker B motif; other site 646529012021 arginine finger; other site 646529012022 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 646529012023 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 646529012024 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 646529012025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529012026 Walker A motif; other site 646529012027 ATP binding site [chemical binding]; other site 646529012028 Walker B motif; other site 646529012029 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 646529012030 trigger factor; Provisional; Region: tig; PRK01490 646529012031 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 646529012032 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 646529012033 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 646529012034 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 646529012035 NodB motif; other site 646529012036 putative active site [active] 646529012037 putative catalytic site [active] 646529012038 putative Zn binding site [ion binding]; other site 646529012039 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 646529012040 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 646529012041 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 646529012042 Predicted membrane protein [Function unknown]; Region: COG2323 646529012043 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 646529012044 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 646529012045 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 646529012046 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 646529012047 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 646529012048 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 646529012049 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 646529012050 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 646529012051 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 646529012052 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 646529012053 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 646529012054 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 646529012055 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 646529012056 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 646529012057 GEMM cis-regulatory element 646529012058 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 646529012059 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 646529012060 Predicted membrane protein [Function unknown]; Region: COG1511 646529012061 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 646529012062 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 646529012063 Predicted membrane protein [Function unknown]; Region: COG1511 646529012064 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 646529012065 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 646529012066 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 646529012067 active site 646529012068 dimerization interface [polypeptide binding]; other site 646529012069 ribonuclease PH; Reviewed; Region: rph; PRK00173 646529012070 Ribonuclease PH; Region: RNase_PH_bact; cd11362 646529012071 hexamer interface [polypeptide binding]; other site 646529012072 active site 646529012073 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 646529012074 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 646529012075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529012076 S-adenosylmethionine binding site [chemical binding]; other site 646529012077 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529012078 Zn2+ binding site [ion binding]; other site 646529012079 Mg2+ binding site [ion binding]; other site 646529012080 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 646529012081 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529012082 Zn2+ binding site [ion binding]; other site 646529012083 Mg2+ binding site [ion binding]; other site 646529012084 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 646529012085 heme-binding site [chemical binding]; other site 646529012086 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529012087 dimer interface [polypeptide binding]; other site 646529012088 putative CheW interface [polypeptide binding]; other site 646529012089 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529012090 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529012091 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529012092 Ribosomal protein L37AE/L43A [Translation, ribosomal structure and biogenesis]; Region: RPL43A; COG1997 646529012093 Fumarase C-terminus; Region: Fumerase_C; cl00795 646529012094 fumarate hydratase; Provisional; Region: PRK06246 646529012095 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 646529012096 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 646529012097 Interdomain contacts; other site 646529012098 Cytokine receptor motif; other site 646529012099 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 646529012100 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 646529012101 Interdomain contacts; other site 646529012102 Cytokine receptor motif; other site 646529012103 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 646529012104 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 646529012105 Interdomain contacts; other site 646529012106 Cytokine receptor motif; other site 646529012107 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 646529012108 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012109 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012110 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012111 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 646529012112 Interdomain contacts; other site 646529012113 Cytokine receptor motif; other site 646529012114 Transposase [DNA replication, recombination, and repair]; Region: COG5421 646529012115 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 646529012116 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 646529012117 methylaspartate ammonia-lyase; Region: B_methylAsp_ase; TIGR01502 646529012118 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 646529012119 dimer interface [polypeptide binding]; other site 646529012120 active site 646529012121 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 646529012122 substrate binding site [chemical binding]; other site 646529012123 B12 cofactor binding site [chemical binding]; other site 646529012124 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 646529012125 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 646529012126 MutL protein; Region: MutL; pfam13941 646529012127 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 646529012128 B12 binding site [chemical binding]; other site 646529012129 heterodimer interface [polypeptide binding]; other site 646529012130 cobalt ligand [ion binding]; other site 646529012131 glutamate racemase; Provisional; Region: PRK00865 646529012132 Predicted transcriptional regulators [Transcription]; Region: COG1725 646529012133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529012134 DNA-binding site [nucleotide binding]; DNA binding site 646529012135 Transthyretin-like family; Region: DUF290; pfam01060 646529012136 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 646529012137 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012138 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012139 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 646529012140 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 646529012141 FtsX-like permease family; Region: FtsX; pfam02687 646529012142 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 646529012143 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 646529012144 Walker A/P-loop; other site 646529012145 ATP binding site [chemical binding]; other site 646529012146 Q-loop/lid; other site 646529012147 ABC transporter signature motif; other site 646529012148 Walker B; other site 646529012149 D-loop; other site 646529012150 H-loop/switch region; other site 646529012151 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 646529012152 HlyD family secretion protein; Region: HlyD_3; pfam13437 646529012153 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 646529012154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529012155 dimerization interface [polypeptide binding]; other site 646529012156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529012157 dimer interface [polypeptide binding]; other site 646529012158 phosphorylation site [posttranslational modification] 646529012159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529012160 ATP binding site [chemical binding]; other site 646529012161 Mg2+ binding site [ion binding]; other site 646529012162 G-X-G motif; other site 646529012163 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 646529012164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529012165 active site 646529012166 phosphorylation site [posttranslational modification] 646529012167 intermolecular recognition site; other site 646529012168 dimerization interface [polypeptide binding]; other site 646529012169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 646529012170 DNA binding site [nucleotide binding] 646529012171 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 646529012172 MarR family; Region: MarR; pfam01047 646529012173 Sporulation and spore germination; Region: Germane; pfam10646 646529012174 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 646529012175 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 646529012176 active site 646529012177 catalytic triad [active] 646529012178 oxyanion hole [active] 646529012179 Protein of unknown function (DUF964); Region: DUF964; pfam06133 646529012180 polyadenylate binding protein, human types 1, 2, 3, 4 family; Region: PABP-1234; TIGR01628 646529012181 phosphodiesterase YaeI; Provisional; Region: PRK11340 646529012182 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 646529012183 putative active site [active] 646529012184 putative metal binding site [ion binding]; other site 646529012185 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 646529012186 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 646529012187 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 646529012188 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 646529012189 C-terminal peptidase (prc); Region: prc; TIGR00225 646529012190 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 646529012191 protein binding site [polypeptide binding]; other site 646529012192 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 646529012193 Catalytic dyad [active] 646529012194 Bacterial Ig-like domain; Region: Big_5; pfam13205 646529012195 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 646529012196 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 646529012197 ATP binding site [chemical binding]; other site 646529012198 Mg++ binding site [ion binding]; other site 646529012199 motif III; other site 646529012200 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529012201 nucleotide binding region [chemical binding]; other site 646529012202 ATP-binding site [chemical binding]; other site 646529012203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529012204 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 646529012205 Walker A/P-loop; other site 646529012206 ligand-binding site [chemical binding]; other site 646529012207 ATP binding site [chemical binding]; other site 646529012208 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 646529012209 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 646529012210 active site 646529012211 Cupin domain; Region: Cupin_2; cl17218 646529012212 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 646529012213 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 646529012214 putative ADP-binding pocket [chemical binding]; other site 646529012215 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 646529012216 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 646529012217 putative carbohydrate binding site [chemical binding]; other site 646529012218 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 646529012219 trimer interface [polypeptide binding]; other site 646529012220 active site 646529012221 substrate binding site [chemical binding]; other site 646529012222 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 646529012223 CoA binding site [chemical binding]; other site 646529012224 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 646529012225 Acyltransferase family; Region: Acyl_transf_3; pfam01757 646529012226 Predicted membrane protein [Function unknown]; Region: COG2246 646529012227 GtrA-like protein; Region: GtrA; pfam04138 646529012228 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 646529012229 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 646529012230 Ligand binding site; other site 646529012231 Putative Catalytic site; other site 646529012232 DXD motif; other site 646529012233 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 646529012234 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 646529012235 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 646529012236 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 646529012237 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 646529012238 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 646529012239 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 646529012240 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 646529012241 Methyltransferase domain; Region: Methyltransf_23; pfam13489 646529012242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529012243 S-adenosylmethionine binding site [chemical binding]; other site 646529012244 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 646529012245 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 646529012246 Walker A/P-loop; other site 646529012247 ATP binding site [chemical binding]; other site 646529012248 Q-loop/lid; other site 646529012249 ABC transporter signature motif; other site 646529012250 Walker B; other site 646529012251 D-loop; other site 646529012252 H-loop/switch region; other site 646529012253 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 646529012254 putative carbohydrate binding site [chemical binding]; other site 646529012255 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 646529012256 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 646529012257 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 646529012258 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 646529012259 NADP-binding site; other site 646529012260 homotetramer interface [polypeptide binding]; other site 646529012261 substrate binding site [chemical binding]; other site 646529012262 homodimer interface [polypeptide binding]; other site 646529012263 active site 646529012264 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 646529012265 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 646529012266 NADP-binding site; other site 646529012267 homotetramer interface [polypeptide binding]; other site 646529012268 substrate binding site [chemical binding]; other site 646529012269 homodimer interface [polypeptide binding]; other site 646529012270 active site 646529012271 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 646529012272 Bacterial sugar transferase; Region: Bac_transf; pfam02397 646529012273 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012274 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012275 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012276 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012277 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012278 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012279 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 646529012280 Interdomain contacts; other site 646529012281 Cytokine receptor motif; other site 646529012282 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 646529012283 Interdomain contacts; other site 646529012284 Cytokine receptor motif; other site 646529012285 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012286 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012287 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012288 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012289 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 646529012290 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012291 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012292 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 646529012293 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 646529012294 active site 646529012295 metal binding site [ion binding]; metal-binding site 646529012296 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 646529012297 active site 646529012298 catalytic triad [active] 646529012299 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012300 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012301 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012302 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012303 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012304 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012305 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 646529012306 active site 646529012307 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 646529012308 Ligand binding site; other site 646529012309 Putative Catalytic site; other site 646529012310 DXD motif; other site 646529012311 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 646529012312 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 646529012313 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 646529012314 N-acetyl-D-glucosamine binding site [chemical binding]; other site 646529012315 catalytic residue [active] 646529012316 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012317 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012318 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012319 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 646529012320 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 646529012321 Coenzyme A binding pocket [chemical binding]; other site 646529012322 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 646529012323 Bacterial sugar transferase; Region: Bac_transf; pfam02397 646529012324 putative glycosyl transferase; Provisional; Region: PRK10307 646529012325 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 646529012326 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 646529012327 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 646529012328 putative active site [active] 646529012329 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 646529012330 active site 646529012331 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 646529012332 homodimer interface [polypeptide binding]; other site 646529012333 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 646529012334 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 646529012335 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 646529012336 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 646529012337 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 646529012338 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 646529012339 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 646529012340 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 646529012341 putative trimer interface [polypeptide binding]; other site 646529012342 putative CoA binding site [chemical binding]; other site 646529012343 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 646529012344 putative trimer interface [polypeptide binding]; other site 646529012345 putative active site [active] 646529012346 putative substrate binding site [chemical binding]; other site 646529012347 putative CoA binding site [chemical binding]; other site 646529012348 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 646529012349 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 646529012350 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 646529012351 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 646529012352 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 646529012353 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 646529012354 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 646529012355 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 646529012356 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 646529012357 NAD(P) binding site [chemical binding]; other site 646529012358 homodimer interface [polypeptide binding]; other site 646529012359 substrate binding site [chemical binding]; other site 646529012360 active site 646529012361 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 646529012362 Acyltransferase family; Region: Acyl_transf_3; pfam01757 646529012363 Acyltransferase family; Region: Acyl_transf_3; pfam01757 646529012364 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 646529012365 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 646529012366 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 646529012367 active site 646529012368 tetramer interface; other site 646529012369 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 646529012370 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 646529012371 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 646529012372 HAMP domain; Region: HAMP; pfam00672 646529012373 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529012374 dimer interface [polypeptide binding]; other site 646529012375 putative CheW interface [polypeptide binding]; other site 646529012376 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529012377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529012378 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529012379 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 646529012380 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 646529012381 oligomer interface [polypeptide binding]; other site 646529012382 active site residues [active] 646529012383 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 646529012384 Nitrogen regulatory protein P-II; Region: P-II; smart00938 646529012385 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 646529012386 Protein of unknown function (DUF445); Region: DUF445; pfam04286 646529012387 Protein of unknown function (DUF445); Region: DUF445; pfam04286 646529012388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 646529012389 Major Facilitator Superfamily; Region: MFS_1; pfam07690 646529012390 putative substrate translocation pore; other site 646529012391 MarR family; Region: MarR; pfam01047 646529012392 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 646529012393 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 646529012394 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 646529012395 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 646529012396 active site 646529012397 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 646529012398 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 646529012399 putative dimer interface [polypeptide binding]; other site 646529012400 [2Fe-2S] cluster binding site [ion binding]; other site 646529012401 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 646529012402 dimer interface [polypeptide binding]; other site 646529012403 [2Fe-2S] cluster binding site [ion binding]; other site 646529012404 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 646529012405 SLBB domain; Region: SLBB; pfam10531 646529012406 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 646529012407 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529012408 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 646529012409 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 646529012410 catalytic loop [active] 646529012411 iron binding site [ion binding]; other site 646529012412 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 646529012413 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 646529012414 4Fe-4S binding domain; Region: Fer4; pfam00037 646529012415 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 646529012416 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 646529012417 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 646529012418 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 646529012419 putative ATP binding site [chemical binding]; other site 646529012420 putative substrate interface [chemical binding]; other site 646529012421 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 646529012422 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529012423 Zn2+ binding site [ion binding]; other site 646529012424 Mg2+ binding site [ion binding]; other site 646529012425 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 646529012426 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 646529012427 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 646529012428 trimer interface [polypeptide binding]; other site 646529012429 putative metal binding site [ion binding]; other site 646529012430 hybrid cluster protein; Provisional; Region: PRK05290 646529012431 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 646529012432 ACS interaction site; other site 646529012433 CODH interaction site; other site 646529012434 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 646529012435 hybrid metal cluster; other site 646529012436 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 646529012437 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 646529012438 Walker A/P-loop; other site 646529012439 ATP binding site [chemical binding]; other site 646529012440 Q-loop/lid; other site 646529012441 ABC transporter signature motif; other site 646529012442 Walker B; other site 646529012443 D-loop; other site 646529012444 H-loop/switch region; other site 646529012445 Predicted transcriptional regulators [Transcription]; Region: COG1725 646529012446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529012447 DNA-binding site [nucleotide binding]; DNA binding site 646529012448 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 646529012449 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 646529012450 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 646529012451 Walker A/P-loop; other site 646529012452 ATP binding site [chemical binding]; other site 646529012453 Q-loop/lid; other site 646529012454 ABC transporter signature motif; other site 646529012455 Walker B; other site 646529012456 D-loop; other site 646529012457 H-loop/switch region; other site 646529012458 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 646529012459 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 646529012460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529012461 Walker A/P-loop; other site 646529012462 ATP binding site [chemical binding]; other site 646529012463 Q-loop/lid; other site 646529012464 ABC transporter signature motif; other site 646529012465 Walker B; other site 646529012466 D-loop; other site 646529012467 H-loop/switch region; other site 646529012468 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 646529012469 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 646529012470 HlyD family secretion protein; Region: HlyD_3; pfam13437 646529012471 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 646529012472 Protein export membrane protein; Region: SecD_SecF; cl14618 646529012473 Predicted transcriptional regulators [Transcription]; Region: COG1695 646529012474 Transcriptional regulator PadR-like family; Region: PadR; cl17335 646529012475 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 646529012476 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 646529012477 Walker A/P-loop; other site 646529012478 ATP binding site [chemical binding]; other site 646529012479 Q-loop/lid; other site 646529012480 ABC transporter signature motif; other site 646529012481 Walker B; other site 646529012482 D-loop; other site 646529012483 H-loop/switch region; other site 646529012484 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 646529012485 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 646529012486 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 646529012487 Walker A/P-loop; other site 646529012488 ATP binding site [chemical binding]; other site 646529012489 Q-loop/lid; other site 646529012490 ABC transporter signature motif; other site 646529012491 Walker B; other site 646529012492 D-loop; other site 646529012493 H-loop/switch region; other site 646529012494 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 646529012495 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 646529012496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529012497 dimer interface [polypeptide binding]; other site 646529012498 conserved gate region; other site 646529012499 putative PBP binding loops; other site 646529012500 ABC-ATPase subunit interface; other site 646529012501 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 646529012502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529012503 dimer interface [polypeptide binding]; other site 646529012504 conserved gate region; other site 646529012505 putative PBP binding loops; other site 646529012506 ABC-ATPase subunit interface; other site 646529012507 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 646529012508 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 646529012509 peptide binding site [polypeptide binding]; other site 646529012510 Response regulator receiver domain; Region: Response_reg; pfam00072 646529012511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529012512 active site 646529012513 phosphorylation site [posttranslational modification] 646529012514 intermolecular recognition site; other site 646529012515 dimerization interface [polypeptide binding]; other site 646529012516 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 646529012517 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529012518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 646529012519 dimer interface [polypeptide binding]; other site 646529012520 phosphorylation site [posttranslational modification] 646529012521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529012522 ATP binding site [chemical binding]; other site 646529012523 Mg2+ binding site [ion binding]; other site 646529012524 G-X-G motif; other site 646529012525 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 646529012526 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529012527 Zn2+ binding site [ion binding]; other site 646529012528 Mg2+ binding site [ion binding]; other site 646529012529 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 646529012530 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 646529012531 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 646529012532 DNA binding residues [nucleotide binding] 646529012533 Uncharacterized conserved protein [Function unknown]; Region: COG2968 646529012534 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 646529012535 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 646529012536 Interdomain contacts; other site 646529012537 Cytokine receptor motif; other site 646529012538 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 646529012539 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 646529012540 oxyanion hole [active] 646529012541 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012542 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 646529012543 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012544 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012545 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 646529012546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529012547 active site 646529012548 phosphorylation site [posttranslational modification] 646529012549 intermolecular recognition site; other site 646529012550 dimerization interface [polypeptide binding]; other site 646529012551 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 646529012552 Histidine kinase; Region: His_kinase; pfam06580 646529012553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529012554 ATP binding site [chemical binding]; other site 646529012555 Mg2+ binding site [ion binding]; other site 646529012556 G-X-G motif; other site 646529012557 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 646529012558 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 646529012559 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 646529012560 Peptidase family M48; Region: Peptidase_M48; pfam01435 646529012561 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 646529012562 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 646529012563 Walker A/P-loop; other site 646529012564 ATP binding site [chemical binding]; other site 646529012565 Q-loop/lid; other site 646529012566 ABC transporter signature motif; other site 646529012567 Walker B; other site 646529012568 D-loop; other site 646529012569 H-loop/switch region; other site 646529012570 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 646529012571 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 646529012572 Walker A/P-loop; other site 646529012573 ATP binding site [chemical binding]; other site 646529012574 Q-loop/lid; other site 646529012575 ABC transporter signature motif; other site 646529012576 Walker B; other site 646529012577 D-loop; other site 646529012578 H-loop/switch region; other site 646529012579 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 646529012580 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 646529012581 TM-ABC transporter signature motif; other site 646529012582 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 646529012583 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 646529012584 TM-ABC transporter signature motif; other site 646529012585 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 646529012586 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 646529012587 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 646529012588 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 646529012589 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 646529012590 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 646529012591 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 646529012592 Cysteine-rich domain; Region: CCG; pfam02754 646529012593 Cysteine-rich domain; Region: CCG; pfam02754 646529012594 Uncharacterized conserved protein [Function unknown]; Region: COG4198 646529012595 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 646529012596 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 646529012597 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 646529012598 putative ligand binding site [chemical binding]; other site 646529012599 putative NAD binding site [chemical binding]; other site 646529012600 putative catalytic site [active] 646529012601 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 646529012602 L-serine binding site [chemical binding]; other site 646529012603 ACT domain interface; other site 646529012604 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 646529012605 homodimer interface [polypeptide binding]; other site 646529012606 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 646529012607 substrate-cofactor binding pocket; other site 646529012608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 646529012609 catalytic residue [active] 646529012610 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 646529012611 Carbon starvation protein CstA; Region: CstA; pfam02554 646529012612 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 646529012613 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 646529012614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529012615 active site 646529012616 phosphorylation site [posttranslational modification] 646529012617 intermolecular recognition site; other site 646529012618 dimerization interface [polypeptide binding]; other site 646529012619 LytTr DNA-binding domain; Region: LytTR; pfam04397 646529012620 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 646529012621 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 646529012622 GAF domain; Region: GAF; cl17456 646529012623 Histidine kinase; Region: His_kinase; pfam06580 646529012624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529012625 ATP binding site [chemical binding]; other site 646529012626 Mg2+ binding site [ion binding]; other site 646529012627 G-X-G motif; other site 646529012628 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 646529012629 Transcriptional regulator [Transcription]; Region: LysR; COG0583 646529012630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 646529012631 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 646529012632 dimerization interface [polypeptide binding]; other site 646529012633 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 646529012634 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 646529012635 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 646529012636 metal binding site [ion binding]; metal-binding site 646529012637 active site 646529012638 I-site; other site 646529012639 GEMM cis-regulatory element 646529012640 Response regulator receiver domain; Region: Response_reg; pfam00072 646529012641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529012642 active site 646529012643 phosphorylation site [posttranslational modification] 646529012644 intermolecular recognition site; other site 646529012645 dimerization interface [polypeptide binding]; other site 646529012646 Late competence development protein ComFB; Region: ComFB; pfam10719 646529012647 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 646529012648 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 646529012649 putative active site [active] 646529012650 metal binding site [ion binding]; metal-binding site 646529012651 Sensory domain found in PocR; Region: PocR; pfam10114 646529012652 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 646529012653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 646529012654 Histidine kinase; Region: His_kinase; pfam06580 646529012655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529012656 ATP binding site [chemical binding]; other site 646529012657 Mg2+ binding site [ion binding]; other site 646529012658 G-X-G motif; other site 646529012659 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 646529012660 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 646529012661 hexamer interface [polypeptide binding]; other site 646529012662 ligand binding site [chemical binding]; other site 646529012663 putative active site [active] 646529012664 NAD(P) binding site [chemical binding]; other site 646529012665 Transposase domain (DUF772); Region: DUF772; pfam05598 646529012666 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 646529012667 Response regulator receiver domain; Region: Response_reg; pfam00072 646529012668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529012669 active site 646529012670 phosphorylation site [posttranslational modification] 646529012671 intermolecular recognition site; other site 646529012672 dimerization interface [polypeptide binding]; other site 646529012673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 646529012674 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 646529012675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 646529012676 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 646529012677 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 646529012678 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 646529012679 NAD binding site [chemical binding]; other site 646529012680 Phe binding site; other site 646529012681 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 646529012682 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 646529012683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 646529012684 putative active site [active] 646529012685 heme pocket [chemical binding]; other site 646529012686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529012687 Walker A motif; other site 646529012688 ATP binding site [chemical binding]; other site 646529012689 Walker B motif; other site 646529012690 arginine finger; other site 646529012691 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 646529012692 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 646529012693 CoA-transferase family III; Region: CoA_transf_3; pfam02515 646529012694 GH3 auxin-responsive promoter; Region: GH3; pfam03321 646529012695 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 646529012696 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 646529012697 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012698 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 646529012699 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012700 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 646529012701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 646529012702 intermolecular recognition site; other site 646529012703 active site 646529012704 dimerization interface [polypeptide binding]; other site 646529012705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529012706 Response regulator receiver domain; Region: Response_reg; pfam00072 646529012707 active site 646529012708 phosphorylation site [posttranslational modification] 646529012709 intermolecular recognition site; other site 646529012710 dimerization interface [polypeptide binding]; other site 646529012711 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 646529012712 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 646529012713 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 646529012714 Histidine kinase; Region: His_kinase; pfam06580 646529012715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 646529012716 ATP binding site [chemical binding]; other site 646529012717 Mg2+ binding site [ion binding]; other site 646529012718 G-X-G motif; other site 646529012719 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 646529012720 active site 646529012721 AAA domain; Region: AAA_21; pfam13304 646529012722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529012723 Walker A/P-loop; other site 646529012724 ATP binding site [chemical binding]; other site 646529012725 Part of AAA domain; Region: AAA_19; pfam13245 646529012726 AAA domain; Region: AAA_18; pfam13238 646529012727 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 646529012728 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 646529012729 PLD-like domain; Region: PLDc_2; pfam13091 646529012730 putative active site [active] 646529012731 catalytic site [active] 646529012732 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 646529012733 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 646529012734 DNA binding residues [nucleotide binding] 646529012735 putative dimer interface [polypeptide binding]; other site 646529012736 Transposase; Region: DEDD_Tnp_IS110; pfam01548 646529012737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 646529012738 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 646529012739 oxidoreductase; Provisional; Region: PRK06196 646529012740 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 646529012741 putative NAD(P) binding site [chemical binding]; other site 646529012742 active site 646529012743 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 646529012744 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 646529012745 catalytic residues [active] 646529012746 catalytic nucleophile [active] 646529012747 Recombinase; Region: Recombinase; pfam07508 646529012748 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 646529012749 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 646529012750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 646529012751 sequence-specific DNA binding site [nucleotide binding]; other site 646529012752 salt bridge; other site 646529012753 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 646529012754 Replication initiation factor; Region: Rep_trans; pfam02486 646529012755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 646529012756 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 646529012757 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 646529012758 Protein of unknown function DUF262; Region: DUF262; pfam03235 646529012759 DNA methylase; Region: N6_N4_Mtase; cl17433 646529012760 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 646529012761 SmpB-tmRNA interface; other site 646529012762 Esterase/lipase [General function prediction only]; Region: COG1647 646529012763 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 646529012764 enolase; Provisional; Region: eno; PRK00077 646529012765 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 646529012766 dimer interface [polypeptide binding]; other site 646529012767 metal binding site [ion binding]; metal-binding site 646529012768 substrate binding pocket [chemical binding]; other site 646529012769 phosphoglyceromutase; Provisional; Region: PRK05434 646529012770 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 646529012771 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 646529012772 triosephosphate isomerase; Provisional; Region: PRK14565 646529012773 substrate binding site [chemical binding]; other site 646529012774 dimer interface [polypeptide binding]; other site 646529012775 catalytic triad [active] 646529012776 Phosphoglycerate kinase; Region: PGK; pfam00162 646529012777 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 646529012778 substrate binding site [chemical binding]; other site 646529012779 hinge regions; other site 646529012780 ADP binding site [chemical binding]; other site 646529012781 catalytic site [active] 646529012782 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 646529012783 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 646529012784 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 646529012785 Cysteine-rich domain; Region: CCG; pfam02754 646529012786 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 646529012787 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 646529012788 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 646529012789 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 646529012790 glycerol kinase; Provisional; Region: glpK; PRK00047 646529012791 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 646529012792 N- and C-terminal domain interface [polypeptide binding]; other site 646529012793 active site 646529012794 MgATP binding site [chemical binding]; other site 646529012795 catalytic site [active] 646529012796 metal binding site [ion binding]; metal-binding site 646529012797 glycerol binding site [chemical binding]; other site 646529012798 homotetramer interface [polypeptide binding]; other site 646529012799 homodimer interface [polypeptide binding]; other site 646529012800 FBP binding site [chemical binding]; other site 646529012801 protein IIAGlc interface [polypeptide binding]; other site 646529012802 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 646529012803 amphipathic channel; other site 646529012804 Asn-Pro-Ala signature motifs; other site 646529012805 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 646529012806 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 646529012807 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 646529012808 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 646529012809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 646529012810 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 646529012811 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 646529012812 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 646529012813 phosphate binding site [ion binding]; other site 646529012814 putative substrate binding pocket [chemical binding]; other site 646529012815 dimer interface [polypeptide binding]; other site 646529012816 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 646529012817 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 646529012818 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 646529012819 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 646529012820 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529012821 FeS/SAM binding site; other site 646529012822 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 646529012823 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 646529012824 active site 646529012825 substrate binding site [chemical binding]; other site 646529012826 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 646529012827 FMN binding site [chemical binding]; other site 646529012828 putative catalytic residues [active] 646529012829 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 646529012830 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 646529012831 motif II; other site 646529012832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 646529012833 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 646529012834 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 646529012835 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 646529012836 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 646529012837 excinuclease ABC subunit B; Provisional; Region: PRK05298 646529012838 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 646529012839 ATP binding site [chemical binding]; other site 646529012840 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529012841 nucleotide binding region [chemical binding]; other site 646529012842 ATP-binding site [chemical binding]; other site 646529012843 Ultra-violet resistance protein B; Region: UvrB; pfam12344 646529012844 UvrB/uvrC motif; Region: UVR; pfam02151 646529012845 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 646529012846 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 646529012847 ligand binding site [chemical binding]; other site 646529012848 HDOD domain; Region: HDOD; pfam08668 646529012849 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 646529012850 hypothetical protein; Provisional; Region: PRK06851 646529012851 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 646529012852 C-terminal peptidase (prc); Region: prc; TIGR00225 646529012853 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 646529012854 protein binding site [polypeptide binding]; other site 646529012855 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 646529012856 Catalytic dyad [active] 646529012857 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 646529012858 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 646529012859 Peptidase family M23; Region: Peptidase_M23; pfam01551 646529012860 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 646529012861 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 646529012862 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 646529012863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 646529012864 Walker A/P-loop; other site 646529012865 ATP binding site [chemical binding]; other site 646529012866 Q-loop/lid; other site 646529012867 ABC transporter signature motif; other site 646529012868 Walker B; other site 646529012869 D-loop; other site 646529012870 H-loop/switch region; other site 646529012871 Predicted transcriptional regulators [Transcription]; Region: COG1725 646529012872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 646529012873 DNA-binding site [nucleotide binding]; DNA binding site 646529012874 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 646529012875 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 646529012876 Walker A/P-loop; other site 646529012877 ATP binding site [chemical binding]; other site 646529012878 Q-loop/lid; other site 646529012879 ABC transporter signature motif; other site 646529012880 Walker B; other site 646529012881 D-loop; other site 646529012882 H-loop/switch region; other site 646529012883 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 646529012884 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 646529012885 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 646529012886 PYR/PP interface [polypeptide binding]; other site 646529012887 dimer interface [polypeptide binding]; other site 646529012888 TPP binding site [chemical binding]; other site 646529012889 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 646529012890 transketolase; Reviewed; Region: PRK05899 646529012891 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 646529012892 TPP-binding site [chemical binding]; other site 646529012893 dimer interface [polypeptide binding]; other site 646529012894 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 646529012895 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 646529012896 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 646529012897 nucleotide binding region [chemical binding]; other site 646529012898 ATP-binding site [chemical binding]; other site 646529012899 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 646529012900 30S subunit binding site; other site 646529012901 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 646529012902 DNA-binding site [nucleotide binding]; DNA binding site 646529012903 RNA-binding motif; other site 646529012904 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 646529012905 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 646529012906 Walker A/P-loop; other site 646529012907 ATP binding site [chemical binding]; other site 646529012908 Q-loop/lid; other site 646529012909 ABC transporter signature motif; other site 646529012910 Walker B; other site 646529012911 D-loop; other site 646529012912 H-loop/switch region; other site 646529012913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 646529012914 dimer interface [polypeptide binding]; other site 646529012915 conserved gate region; other site 646529012916 putative PBP binding loops; other site 646529012917 ABC-ATPase subunit interface; other site 646529012918 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 646529012919 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 646529012920 substrate binding pocket [chemical binding]; other site 646529012921 membrane-bound complex binding site; other site 646529012922 hinge residues; other site 646529012923 Probable zinc-binding domain; Region: zf-trcl; pfam13451 646529012924 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 646529012925 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 646529012926 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 646529012927 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 646529012928 ATP binding site [chemical binding]; other site 646529012929 putative Mg++ binding site [ion binding]; other site 646529012930 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 646529012931 nucleotide binding region [chemical binding]; other site 646529012932 ATP-binding site [chemical binding]; other site 646529012933 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 646529012934 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 646529012935 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 646529012936 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 646529012937 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 646529012938 rod shape-determining protein Mbl; Provisional; Region: PRK13928 646529012939 MreB and similar proteins; Region: MreB_like; cd10225 646529012940 nucleotide binding site [chemical binding]; other site 646529012941 Mg binding site [ion binding]; other site 646529012942 putative protofilament interaction site [polypeptide binding]; other site 646529012943 RodZ interaction site [polypeptide binding]; other site 646529012944 Stage III sporulation protein D; Region: SpoIIID; pfam12116 646529012945 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 646529012946 Peptidase family M23; Region: Peptidase_M23; pfam01551 646529012947 Stage II sporulation protein; Region: SpoIID; pfam08486 646529012948 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 646529012949 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 646529012950 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 646529012951 hinge; other site 646529012952 active site 646529012953 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 646529012954 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 646529012955 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 646529012956 gamma subunit interface [polypeptide binding]; other site 646529012957 epsilon subunit interface [polypeptide binding]; other site 646529012958 LBP interface [polypeptide binding]; other site 646529012959 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 646529012960 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 646529012961 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 646529012962 alpha subunit interaction interface [polypeptide binding]; other site 646529012963 Walker A motif; other site 646529012964 ATP binding site [chemical binding]; other site 646529012965 Walker B motif; other site 646529012966 inhibitor binding site; inhibition site 646529012967 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 646529012968 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 646529012969 core domain interface [polypeptide binding]; other site 646529012970 delta subunit interface [polypeptide binding]; other site 646529012971 epsilon subunit interface [polypeptide binding]; other site 646529012972 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 646529012973 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 646529012974 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 646529012975 beta subunit interaction interface [polypeptide binding]; other site 646529012976 Walker A motif; other site 646529012977 ATP binding site [chemical binding]; other site 646529012978 Walker B motif; other site 646529012979 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 646529012980 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 646529012981 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 646529012982 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 646529012983 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 646529012984 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 646529012985 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 646529012986 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 646529012987 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 646529012988 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 646529012989 active site 646529012990 homodimer interface [polypeptide binding]; other site 646529012991 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 646529012992 catalytic motif [active] 646529012993 Zn binding site [ion binding]; other site 646529012994 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 646529012995 active site 646529012996 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 646529012997 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 646529012998 dimer interface [polypeptide binding]; other site 646529012999 active site 646529013000 glycine-pyridoxal phosphate binding site [chemical binding]; other site 646529013001 folate binding site [chemical binding]; other site 646529013002 hypothetical protein; Provisional; Region: PRK13690 646529013003 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 646529013004 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 646529013005 Low molecular weight phosphatase family; Region: LMWPc; cd00115 646529013006 active site 646529013007 Predicted membrane protein [Function unknown]; Region: COG1971 646529013008 Domain of unknown function DUF; Region: DUF204; pfam02659 646529013009 Domain of unknown function DUF; Region: DUF204; pfam02659 646529013010 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 646529013011 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 646529013012 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 646529013013 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 646529013014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 646529013015 S-adenosylmethionine binding site [chemical binding]; other site 646529013016 peptide chain release factor 1; Validated; Region: prfA; PRK00591 646529013017 This domain is found in peptide chain release factors; Region: PCRF; smart00937 646529013018 RF-1 domain; Region: RF-1; pfam00472 646529013019 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 646529013020 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 646529013021 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 646529013022 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 646529013023 putative active site [active] 646529013024 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 646529013025 active site 646529013026 intersubunit interactions; other site 646529013027 catalytic residue [active] 646529013028 Fumarase C C-terminus; Region: FumaraseC_C; pfam10415 646529013029 Response regulator receiver domain; Region: Response_reg; pfam00072 646529013030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 646529013031 active site 646529013032 phosphorylation site [posttranslational modification] 646529013033 intermolecular recognition site; other site 646529013034 dimerization interface [polypeptide binding]; other site 646529013035 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 646529013036 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 646529013037 active site 646529013038 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 646529013039 dimer interface [polypeptide binding]; other site 646529013040 substrate binding site [chemical binding]; other site 646529013041 catalytic residues [active] 646529013042 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 646529013043 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 646529013044 CTP synthetase; Validated; Region: pyrG; PRK05380 646529013045 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 646529013046 Catalytic site [active] 646529013047 active site 646529013048 UTP binding site [chemical binding]; other site 646529013049 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 646529013050 active site 646529013051 putative oxyanion hole; other site 646529013052 catalytic triad [active] 646529013053 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 646529013054 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 646529013055 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 646529013056 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 646529013057 active site 646529013058 HIGH motif; other site 646529013059 KMSK motif region; other site 646529013060 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 646529013061 tRNA binding surface [nucleotide binding]; other site 646529013062 anticodon binding site; other site 646529013063 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 646529013064 germination protein YpeB; Region: spore_YpeB; TIGR02889 646529013065 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 646529013066 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 646529013067 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 646529013068 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 646529013069 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529013070 FeS/SAM binding site; other site 646529013071 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 646529013072 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 646529013073 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 646529013074 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 646529013075 putative deacylase active site [active] 646529013076 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 646529013077 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 646529013078 active site 646529013079 HIGH motif; other site 646529013080 nucleotide binding site [chemical binding]; other site 646529013081 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 646529013082 KMSKS motif; other site 646529013083 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 646529013084 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 646529013085 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 646529013086 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 646529013087 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 646529013088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 646529013089 TPR motif; other site 646529013090 binding surface 646529013091 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 646529013092 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 646529013093 putative [4Fe-4S] binding site [ion binding]; other site 646529013094 putative molybdopterin cofactor binding site [chemical binding]; other site 646529013095 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 646529013096 molybdopterin cofactor binding site; other site 646529013097 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 646529013098 PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353 646529013099 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 646529013100 FeS/SAM binding site; other site 646529013101 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 646529013102 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 646529013103 ykoK leader 646529013104 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 646529013105 MgtE intracellular N domain; Region: MgtE_N; smart00924 646529013106 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 646529013107 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 646529013108 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 646529013109 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 646529013110 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 646529013111 active site 646529013112 metal binding site [ion binding]; metal-binding site 646529013113 GEMM cis-regulatory element 646529013114 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 646529013115 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 646529013116 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 646529013117 Zn2+ binding site [ion binding]; other site 646529013118 Mg2+ binding site [ion binding]; other site 646529013119 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 646529013120 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 646529013121 dimerization interface [polypeptide binding]; other site 646529013122 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 646529013123 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 646529013124 dimer interface [polypeptide binding]; other site 646529013125 putative CheW interface [polypeptide binding]; other site 646529013126 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 646529013127 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 646529013128 GDP-binding site [chemical binding]; other site 646529013129 ACT binding site; other site 646529013130 IMP binding site; other site 646529013131 adenylosuccinate lyase; Provisional; Region: PRK07380 646529013132 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 646529013133 tetramer interface [polypeptide binding]; other site 646529013134 active site 646529013135 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 646529013136 L-aspartate oxidase; Provisional; Region: PRK06175 646529013137 replicative DNA helicase; Region: DnaB; TIGR00665 646529013138 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 646529013139 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 646529013140 Walker A motif; other site 646529013141 ATP binding site [chemical binding]; other site 646529013142 Walker B motif; other site 646529013143 DNA binding loops [nucleotide binding] 646529013144 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 646529013145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 646529013146 Walker A motif; other site 646529013147 ATP binding site [chemical binding]; other site 646529013148 Walker B motif; other site 646529013149 arginine finger; other site 646529013150 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 646529013151 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 646529013152 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 646529013153 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 646529013154 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 646529013155 MazG-like family; Region: MazG-like; pfam12643 646529013156 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 646529013157 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 646529013158 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 646529013159 dimer interface [polypeptide binding]; other site 646529013160 ssDNA binding site [nucleotide binding]; other site 646529013161 tetramer (dimer of dimers) interface [polypeptide binding]; other site 646529013162 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 646529013163 GTP-binding protein YchF; Reviewed; Region: PRK09601 646529013164 YchF GTPase; Region: YchF; cd01900 646529013165 G1 box; other site 646529013166 GTP/Mg2+ binding site [chemical binding]; other site 646529013167 Switch I region; other site 646529013168 G2 box; other site 646529013169 Switch II region; other site 646529013170 G3 box; other site 646529013171 G4 box; other site 646529013172 G5 box; other site 646529013173 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 646529013174 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 646529013175 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 646529013176 Mechanosensitive ion channel; Region: MS_channel; pfam00924 646529013177 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 646529013178 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 646529013179 oligomer interface [polypeptide binding]; other site 646529013180 putative active site [active] 646529013181 metal binding site [ion binding]; metal-binding site 646529013182 FOG: CBS domain [General function prediction only]; Region: COG0517 646529013183 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 646529013184 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 646529013185 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 646529013186 Walker A/P-loop; other site 646529013187 ATP binding site [chemical binding]; other site 646529013188 Q-loop/lid; other site 646529013189 ABC transporter signature motif; other site 646529013190 Walker B; other site 646529013191 D-loop; other site 646529013192 H-loop/switch region; other site 646529013193 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 646529013194 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 646529013195 Walker A/P-loop; other site 646529013196 ATP binding site [chemical binding]; other site 646529013197 Q-loop/lid; other site 646529013198 ABC transporter signature motif; other site 646529013199 Walker B; other site 646529013200 D-loop; other site 646529013201 H-loop/switch region; other site 646529013202 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 646529013203 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 646529013204 TM-ABC transporter signature motif; other site 646529013205 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 646529013206 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 646529013207 TM-ABC transporter signature motif; other site 646529013208 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 646529013209 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 646529013210 putative ligand binding site [chemical binding]; other site 646529013211 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 646529013212 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 646529013213 putative ligand binding site [chemical binding]; other site 646529013214 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 646529013215 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 646529013216 G1 box; other site 646529013217 putative GEF interaction site [polypeptide binding]; other site 646529013218 GTP/Mg2+ binding site [chemical binding]; other site 646529013219 Switch I region; other site 646529013220 G2 box; other site 646529013221 G3 box; other site 646529013222 Switch II region; other site 646529013223 G4 box; other site 646529013224 G5 box; other site 646529013225 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 646529013226 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 646529013227 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 646529013228 Uncharacterized membrane protein [Function unknown]; Region: COG3949 646529013229 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 646529013230 Protein of unknown function (DUF554); Region: DUF554; pfam04474 646529013231 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 646529013232 ParB-like nuclease domain; Region: ParB; smart00470 646529013233 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 646529013234 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 646529013235 P-loop; other site 646529013236 Magnesium ion binding site [ion binding]; other site 646529013237 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 646529013238 Magnesium ion binding site [ion binding]; other site 646529013239 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 646529013240 VanW like protein; Region: VanW; pfam04294 646529013241 G5 domain; Region: G5; pfam07501 646529013242 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 646529013243 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 646529013244 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 646529013245 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 646529013246 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 646529013247 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 646529013248 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 646529013249 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 646529013250 trmE is a tRNA modification GTPase; Region: trmE; cd04164 646529013251 G1 box; other site 646529013252 GTP/Mg2+ binding site [chemical binding]; other site 646529013253 Switch I region; other site 646529013254 G2 box; other site 646529013255 Switch II region; other site 646529013256 G3 box; other site 646529013257 G4 box; other site 646529013258 G5 box; other site 646529013259 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 646529013260 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 646529013261 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 646529013262 G-X-X-G motif; other site 646529013263 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 646529013264 RxxxH motif; other site 646529013265 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 646529013266 Haemolytic domain; Region: Haemolytic; pfam01809 646529013267 ribonuclease P; Reviewed; Region: rnpA; PRK00499