-- dump date 20140619_063642 -- class Genbank::misc_feature -- table misc_feature_note -- id note 868595000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 868595000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 868595000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000004 Walker A motif; other site 868595000005 ATP binding site [chemical binding]; other site 868595000006 Walker B motif; other site 868595000007 arginine finger; other site 868595000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 868595000009 DnaA box-binding interface [nucleotide binding]; other site 868595000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 868595000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 868595000012 putative DNA binding surface [nucleotide binding]; other site 868595000013 dimer interface [polypeptide binding]; other site 868595000014 beta-clamp/clamp loader binding surface; other site 868595000015 beta-clamp/translesion DNA polymerase binding surface; other site 868595000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595000017 RNA binding surface [nucleotide binding]; other site 868595000018 recombination protein F; Reviewed; Region: recF; PRK00064 868595000019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 868595000020 Walker A/P-loop; other site 868595000021 ATP binding site [chemical binding]; other site 868595000022 Q-loop/lid; other site 868595000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 868595000024 ABC transporter signature motif; other site 868595000025 Walker B; other site 868595000026 D-loop; other site 868595000027 H-loop/switch region; other site 868595000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 868595000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595000030 Mg2+ binding site [ion binding]; other site 868595000031 G-X-G motif; other site 868595000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 868595000033 anchoring element; other site 868595000034 dimer interface [polypeptide binding]; other site 868595000035 ATP binding site [chemical binding]; other site 868595000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 868595000037 active site 868595000038 putative metal-binding site [ion binding]; other site 868595000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 868595000040 Methyltransferase domain; Region: Methyltransf_23; pfam13489 868595000041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595000042 S-adenosylmethionine binding site [chemical binding]; other site 868595000043 DNA gyrase subunit A; Validated; Region: PRK05560 868595000044 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 868595000045 CAP-like domain; other site 868595000046 active site 868595000047 primary dimer interface [polypeptide binding]; other site 868595000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 868595000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 868595000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 868595000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 868595000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 868595000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 868595000054 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595000055 Zn2+ binding site [ion binding]; other site 868595000056 Mg2+ binding site [ion binding]; other site 868595000057 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 868595000058 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595000059 Zn2+ binding site [ion binding]; other site 868595000060 Mg2+ binding site [ion binding]; other site 868595000061 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 868595000062 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 868595000063 active site 868595000064 multimer interface [polypeptide binding]; other site 868595000065 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 868595000066 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 868595000067 predicted active site [active] 868595000068 catalytic triad [active] 868595000069 Accessory gene regulator B; Region: AgrB; pfam04647 868595000070 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 868595000071 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 868595000072 PAS domain; Region: PAS; smart00091 868595000073 putative active site [active] 868595000074 heme pocket [chemical binding]; other site 868595000075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595000076 dimer interface [polypeptide binding]; other site 868595000077 phosphorylation site [posttranslational modification] 868595000078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595000079 ATP binding site [chemical binding]; other site 868595000080 Mg2+ binding site [ion binding]; other site 868595000081 G-X-G motif; other site 868595000082 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 868595000083 homodimer interface [polypeptide binding]; other site 868595000084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595000085 catalytic residue [active] 868595000086 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 868595000087 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 868595000088 ligand binding site [chemical binding]; other site 868595000089 NAD binding site [chemical binding]; other site 868595000090 dimerization interface [polypeptide binding]; other site 868595000091 catalytic site [active] 868595000092 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 868595000093 putative L-serine binding site [chemical binding]; other site 868595000094 seryl-tRNA synthetase; Provisional; Region: PRK05431 868595000095 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 868595000096 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 868595000097 dimer interface [polypeptide binding]; other site 868595000098 active site 868595000099 motif 1; other site 868595000100 motif 2; other site 868595000101 motif 3; other site 868595000102 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 868595000103 nucleoside/Zn binding site; other site 868595000104 dimer interface [polypeptide binding]; other site 868595000105 catalytic motif [active] 868595000106 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595000107 Zn2+ binding site [ion binding]; other site 868595000108 Mg2+ binding site [ion binding]; other site 868595000109 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 868595000110 GIY-YIG motif/motif A; other site 868595000111 active site 868595000112 catalytic site [active] 868595000113 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 868595000114 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 868595000115 FMN binding site [chemical binding]; other site 868595000116 dimer interface [polypeptide binding]; other site 868595000117 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 868595000118 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 868595000119 Cl- selectivity filter; other site 868595000120 Cl- binding residues [ion binding]; other site 868595000121 pore gating glutamate residue; other site 868595000122 dimer interface [polypeptide binding]; other site 868595000123 H+/Cl- coupling transport residue; other site 868595000124 TrkA-C domain; Region: TrkA_C; pfam02080 868595000125 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 868595000126 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 868595000127 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 868595000128 active site 868595000129 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 868595000130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000131 Walker A motif; other site 868595000132 ATP binding site [chemical binding]; other site 868595000133 Walker B motif; other site 868595000134 arginine finger; other site 868595000135 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 868595000136 hypothetical protein; Validated; Region: PRK00153 868595000137 recombination protein RecR; Reviewed; Region: recR; PRK00076 868595000138 RecR protein; Region: RecR; pfam02132 868595000139 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 868595000140 putative active site [active] 868595000141 putative metal-binding site [ion binding]; other site 868595000142 tetramer interface [polypeptide binding]; other site 868595000143 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 868595000144 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 868595000145 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 868595000146 dimer interface [polypeptide binding]; other site 868595000147 PYR/PP interface [polypeptide binding]; other site 868595000148 TPP binding site [chemical binding]; other site 868595000149 substrate binding site [chemical binding]; other site 868595000150 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 868595000151 TPP-binding site [chemical binding]; other site 868595000152 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 868595000153 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 868595000154 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595000155 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 868595000156 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 868595000157 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 868595000158 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 868595000159 homodimer interface [polypeptide binding]; other site 868595000160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595000161 catalytic residue [active] 868595000162 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 868595000163 thymidylate kinase; Validated; Region: tmk; PRK00698 868595000164 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 868595000165 TMP-binding site; other site 868595000166 ATP-binding site [chemical binding]; other site 868595000167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000168 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 868595000169 Walker A motif; other site 868595000170 ATP binding site [chemical binding]; other site 868595000171 DNA polymerase III subunit delta'; Validated; Region: PRK08485 868595000172 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 868595000173 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 868595000174 Protein of unknown function (DUF972); Region: DUF972; pfam06156 868595000175 Predicted methyltransferases [General function prediction only]; Region: COG0313 868595000176 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 868595000177 putative SAM binding site [chemical binding]; other site 868595000178 putative homodimer interface [polypeptide binding]; other site 868595000179 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 868595000180 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 868595000181 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 868595000182 active site 868595000183 HIGH motif; other site 868595000184 KMSKS motif; other site 868595000185 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 868595000186 tRNA binding surface [nucleotide binding]; other site 868595000187 anticodon binding site; other site 868595000188 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 868595000189 active site 868595000190 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 868595000191 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 868595000192 homodimer interface [polypeptide binding]; other site 868595000193 Walker A motif; other site 868595000194 ATP binding site [chemical binding]; other site 868595000195 hydroxycobalamin binding site [chemical binding]; other site 868595000196 Walker B motif; other site 868595000197 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 868595000198 Domain of unknown function (DUF348); Region: DUF348; pfam03990 868595000199 G5 domain; Region: G5; pfam07501 868595000200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 868595000201 Domain of unknown function (DUF348); Region: DUF348; pfam03990 868595000202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 868595000203 biotin synthase; Region: bioB; TIGR00433 868595000204 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595000205 FeS/SAM binding site; other site 868595000206 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 868595000207 AAA domain; Region: AAA_26; pfam13500 868595000208 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 868595000209 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 868595000210 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 868595000211 substrate-cofactor binding pocket; other site 868595000212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595000213 catalytic residue [active] 868595000214 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 868595000215 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 868595000216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595000217 S-adenosylmethionine binding site [chemical binding]; other site 868595000218 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 868595000219 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 868595000220 inhibitor-cofactor binding pocket; inhibition site 868595000221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595000222 catalytic residue [active] 868595000223 intracellular protease, PfpI family; Region: PfpI; TIGR01382 868595000224 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 868595000225 proposed catalytic triad [active] 868595000226 conserved cys residue [active] 868595000227 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 868595000228 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 868595000229 Na binding site [ion binding]; other site 868595000230 thiazole synthase; Reviewed; Region: thiG; PRK00208 868595000231 phosphate binding site [ion binding]; other site 868595000232 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 868595000233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595000234 FeS/SAM binding site; other site 868595000235 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 868595000236 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 868595000237 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 868595000238 ATP binding site [chemical binding]; other site 868595000239 substrate interface [chemical binding]; other site 868595000240 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 868595000241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595000242 S-adenosylmethionine binding site [chemical binding]; other site 868595000243 Protein of unknown function (DUF458); Region: DUF458; pfam04308 868595000244 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 868595000245 YabG peptidase U57; Region: Peptidase_U57; pfam05582 868595000246 Peptidase family S64; Region: Peptidase_S64; pfam08192 868595000247 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 868595000248 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 868595000249 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 868595000250 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 868595000251 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 868595000252 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 868595000253 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 868595000254 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 868595000255 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 868595000256 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 868595000257 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 868595000258 Herpesvirus UL16/UL94 family; Region: Herpes_UL16; cl17477 868595000259 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 868595000260 active site 868595000261 catalytic residues [active] 868595000262 Heavy-metal-associated domain; Region: HMA; pfam00403 868595000263 Protein of unknown function, DUF606; Region: DUF606; pfam04657 868595000264 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 868595000265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 868595000266 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 868595000267 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 868595000268 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 868595000269 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 868595000270 Transcriptional regulators [Transcription]; Region: GntR; COG1802 868595000271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 868595000272 DNA-binding site [nucleotide binding]; DNA binding site 868595000273 FCD domain; Region: FCD; pfam07729 868595000274 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 868595000275 active site 868595000276 threonine dehydratase; Provisional; Region: PRK08198 868595000277 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 868595000278 tetramer interface [polypeptide binding]; other site 868595000279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595000280 catalytic residue [active] 868595000281 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 868595000282 regulatory protein SpoVG; Reviewed; Region: PRK13259 868595000283 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 868595000284 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 868595000285 Substrate binding site; other site 868595000286 Mg++ binding site; other site 868595000287 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 868595000288 active site 868595000289 substrate binding site [chemical binding]; other site 868595000290 CoA binding site [chemical binding]; other site 868595000291 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 868595000292 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 868595000293 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595000294 active site 868595000295 Domain of unknown function DUF39; Region: DUF39; pfam01837 868595000296 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 868595000297 4Fe-4S binding domain; Region: Fer4; cl02805 868595000298 hypothetical protein; Provisional; Region: PRK04334 868595000299 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 868595000300 diiron binding motif [ion binding]; other site 868595000301 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 868595000302 PRC-barrel domain; Region: PRC; pfam05239 868595000303 PRC-barrel domain; Region: PRC; pfam05239 868595000304 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 868595000305 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 868595000306 5S rRNA interface [nucleotide binding]; other site 868595000307 CTC domain interface [polypeptide binding]; other site 868595000308 L16 interface [polypeptide binding]; other site 868595000309 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 868595000310 putative active site [active] 868595000311 catalytic residue [active] 868595000312 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 868595000313 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 868595000314 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595000315 ATP binding site [chemical binding]; other site 868595000316 putative Mg++ binding site [ion binding]; other site 868595000317 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595000318 nucleotide binding region [chemical binding]; other site 868595000319 ATP-binding site [chemical binding]; other site 868595000320 TRCF domain; Region: TRCF; pfam03461 868595000321 SurA N-terminal domain; Region: SurA_N_3; cl07813 868595000322 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 868595000323 stage V sporulation protein T; Region: spore_V_T; TIGR02851 868595000324 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 868595000325 GAF domain; Region: GAF; pfam01590 868595000326 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 868595000327 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 868595000328 putative SAM binding site [chemical binding]; other site 868595000329 putative homodimer interface [polypeptide binding]; other site 868595000330 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 868595000331 homodimer interface [polypeptide binding]; other site 868595000332 metal binding site [ion binding]; metal-binding site 868595000333 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 868595000334 homodimer interface [polypeptide binding]; other site 868595000335 active site 868595000336 putative chemical substrate binding site [chemical binding]; other site 868595000337 metal binding site [ion binding]; metal-binding site 868595000338 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 868595000339 IHF dimer interface [polypeptide binding]; other site 868595000340 IHF - DNA interface [nucleotide binding]; other site 868595000341 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595000342 RNA binding surface [nucleotide binding]; other site 868595000343 Stage II sporulation protein; Region: SpoIID; pfam08486 868595000344 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 868595000345 YabP family; Region: YabP; cl06766 868595000346 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 868595000347 DNA binding residues [nucleotide binding] 868595000348 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 868595000349 Septum formation initiator; Region: DivIC; pfam04977 868595000350 hypothetical protein; Provisional; Region: PRK08582 868595000351 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 868595000352 RNA binding site [nucleotide binding]; other site 868595000353 exopolyphosphatase; Region: exo_poly_only; TIGR03706 868595000354 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 868595000355 stage II sporulation protein E; Region: spore_II_E; TIGR02865 868595000356 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 868595000357 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 868595000358 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 868595000359 TilS substrate C-terminal domain; Region: TilS_C; smart00977 868595000360 FtsH Extracellular; Region: FtsH_ext; pfam06480 868595000361 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 868595000362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000363 Walker A motif; other site 868595000364 ATP binding site [chemical binding]; other site 868595000365 Walker B motif; other site 868595000366 arginine finger; other site 868595000367 Peptidase family M41; Region: Peptidase_M41; pfam01434 868595000368 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595000369 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595000370 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 868595000371 active site 868595000372 multimer interface [polypeptide binding]; other site 868595000373 Predicted thioesterase [General function prediction only]; Region: COG5496 868595000374 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 868595000375 amphipathic channel; other site 868595000376 Asn-Pro-Ala signature motifs; other site 868595000377 glycerol kinase; Provisional; Region: glpK; PRK00047 868595000378 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 868595000379 N- and C-terminal domain interface [polypeptide binding]; other site 868595000380 active site 868595000381 MgATP binding site [chemical binding]; other site 868595000382 catalytic site [active] 868595000383 metal binding site [ion binding]; metal-binding site 868595000384 glycerol binding site [chemical binding]; other site 868595000385 homotetramer interface [polypeptide binding]; other site 868595000386 homodimer interface [polypeptide binding]; other site 868595000387 FBP binding site [chemical binding]; other site 868595000388 protein IIAGlc interface [polypeptide binding]; other site 868595000389 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 868595000390 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 868595000391 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 868595000392 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 868595000393 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 868595000394 Cysteine-rich domain; Region: CCG; pfam02754 868595000395 Cysteine-rich domain; Region: CCG; pfam02754 868595000396 pyruvate kinase; Provisional; Region: PRK06354 868595000397 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 868595000398 domain interfaces; other site 868595000399 active site 868595000400 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 868595000401 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 868595000402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 868595000403 DNA-binding site [nucleotide binding]; DNA binding site 868595000404 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 868595000405 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 868595000406 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 868595000407 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 868595000408 Phosphoglycerate kinase; Region: PGK; pfam00162 868595000409 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 868595000410 substrate binding site [chemical binding]; other site 868595000411 hinge regions; other site 868595000412 ADP binding site [chemical binding]; other site 868595000413 catalytic site [active] 868595000414 triosephosphate isomerase; Provisional; Region: PRK14565 868595000415 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 868595000416 substrate binding site [chemical binding]; other site 868595000417 dimer interface [polypeptide binding]; other site 868595000418 catalytic triad [active] 868595000419 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 868595000420 phosphoglyceromutase; Provisional; Region: PRK05434 868595000421 enolase; Provisional; Region: eno; PRK00077 868595000422 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 868595000423 dimer interface [polypeptide binding]; other site 868595000424 metal binding site [ion binding]; metal-binding site 868595000425 substrate binding pocket [chemical binding]; other site 868595000426 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 868595000427 Ferredoxin [Energy production and conversion]; Region: COG1146 868595000428 4Fe-4S binding domain; Region: Fer4; pfam00037 868595000429 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 868595000430 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 868595000431 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595000432 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 868595000433 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595000434 4Fe-4S binding domain; Region: Fer4; pfam00037 868595000435 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 868595000436 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 868595000437 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 868595000438 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 868595000439 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 868595000440 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 868595000441 FAD binding pocket [chemical binding]; other site 868595000442 FAD binding motif [chemical binding]; other site 868595000443 phosphate binding motif [ion binding]; other site 868595000444 beta-alpha-beta structure motif; other site 868595000445 NAD binding pocket [chemical binding]; other site 868595000446 Iron coordination center [ion binding]; other site 868595000447 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 868595000448 Cysteine-rich domain; Region: CCG; pfam02754 868595000449 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 868595000450 Ferredoxin [Energy production and conversion]; Region: COG1146 868595000451 4Fe-4S binding domain; Region: Fer4; pfam00037 868595000452 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 868595000453 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 868595000454 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595000455 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 868595000456 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595000457 4Fe-4S binding domain; Region: Fer4; pfam00037 868595000458 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 868595000459 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 868595000460 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 868595000461 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 868595000462 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 868595000463 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 868595000464 FAD binding pocket [chemical binding]; other site 868595000465 FAD binding motif [chemical binding]; other site 868595000466 phosphate binding motif [ion binding]; other site 868595000467 beta-alpha-beta structure motif; other site 868595000468 NAD binding pocket [chemical binding]; other site 868595000469 Iron coordination center [ion binding]; other site 868595000470 Transposase domain (DUF772); Region: DUF772; pfam05598 868595000471 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595000472 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 868595000473 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 868595000474 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 868595000475 CoenzymeA binding site [chemical binding]; other site 868595000476 subunit interaction site [polypeptide binding]; other site 868595000477 PHB binding site; other site 868595000478 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 868595000479 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 868595000480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595000481 putative active site [active] 868595000482 heme pocket [chemical binding]; other site 868595000483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000484 Walker A motif; other site 868595000485 ATP binding site [chemical binding]; other site 868595000486 Walker B motif; other site 868595000487 arginine finger; other site 868595000488 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 868595000489 Na binding site [ion binding]; other site 868595000490 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 868595000491 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 868595000492 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 868595000493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 868595000494 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 868595000495 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 868595000496 putative FMN binding site [chemical binding]; other site 868595000497 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 868595000498 dihydropteroate synthase; Region: DHPS; TIGR01496 868595000499 substrate binding pocket [chemical binding]; other site 868595000500 dimer interface [polypeptide binding]; other site 868595000501 inhibitor binding site; inhibition site 868595000502 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 868595000503 homooctamer interface [polypeptide binding]; other site 868595000504 active site 868595000505 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 868595000506 catalytic center binding site [active] 868595000507 ATP binding site [chemical binding]; other site 868595000508 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 868595000509 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 868595000510 active site 868595000511 NTP binding site [chemical binding]; other site 868595000512 metal binding triad [ion binding]; metal-binding site 868595000513 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 868595000514 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595000515 Zn2+ binding site [ion binding]; other site 868595000516 Mg2+ binding site [ion binding]; other site 868595000517 Uncharacterized conserved protein [Function unknown]; Region: COG5495 868595000518 Rossmann-like domain; Region: Rossmann-like; pfam10727 868595000519 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 868595000520 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 868595000521 oligomerization interface [polypeptide binding]; other site 868595000522 active site 868595000523 metal binding site [ion binding]; metal-binding site 868595000524 pantoate--beta-alanine ligase; Region: panC; TIGR00018 868595000525 Pantoate-beta-alanine ligase; Region: PanC; cd00560 868595000526 active site 868595000527 ATP-binding site [chemical binding]; other site 868595000528 pantoate-binding site; other site 868595000529 HXXH motif; other site 868595000530 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 868595000531 tetramerization interface [polypeptide binding]; other site 868595000532 active site 868595000533 Quinolinate synthetase A protein; Region: NadA; pfam02445 868595000534 L-aspartate oxidase; Provisional; Region: PRK06175 868595000535 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 868595000536 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 868595000537 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 868595000538 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 868595000539 dimerization interface [polypeptide binding]; other site 868595000540 active site 868595000541 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595000542 putative DNA binding site [nucleotide binding]; other site 868595000543 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 868595000544 putative Zn2+ binding site [ion binding]; other site 868595000545 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 868595000546 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 868595000547 BioY family; Region: BioY; pfam02632 868595000548 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 868595000549 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 868595000550 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595000551 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595000552 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 868595000553 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 868595000554 DNA binding residues [nucleotide binding] 868595000555 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 868595000556 catalytic residues [active] 868595000557 catalytic nucleophile [active] 868595000558 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 868595000559 nucleotide binding site [chemical binding]; other site 868595000560 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 868595000561 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 868595000562 FMN binding site [chemical binding]; other site 868595000563 active site 868595000564 catalytic residues [active] 868595000565 substrate binding site [chemical binding]; other site 868595000566 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 868595000567 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 868595000568 NAD(P) binding pocket [chemical binding]; other site 868595000569 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 868595000570 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 868595000571 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 868595000572 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 868595000573 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 868595000574 dimer interface [polypeptide binding]; other site 868595000575 putative anticodon binding site; other site 868595000576 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 868595000577 motif 1; other site 868595000578 active site 868595000579 motif 2; other site 868595000580 motif 3; other site 868595000581 Predicted membrane protein [Function unknown]; Region: COG2860 868595000582 UPF0126 domain; Region: UPF0126; pfam03458 868595000583 UPF0126 domain; Region: UPF0126; pfam03458 868595000584 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 868595000585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000586 Walker A motif; other site 868595000587 ATP binding site [chemical binding]; other site 868595000588 Walker B motif; other site 868595000589 arginine finger; other site 868595000590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000591 Walker A motif; other site 868595000592 ATP binding site [chemical binding]; other site 868595000593 Walker B motif; other site 868595000594 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 868595000595 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 868595000596 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 868595000597 UvrB/uvrC motif; Region: UVR; pfam02151 868595000598 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 868595000599 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 868595000600 ADP binding site [chemical binding]; other site 868595000601 phosphagen binding site; other site 868595000602 substrate specificity loop; other site 868595000603 Clp protease ATP binding subunit; Region: clpC; CHL00095 868595000604 Clp amino terminal domain; Region: Clp_N; pfam02861 868595000605 Clp amino terminal domain; Region: Clp_N; pfam02861 868595000606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000607 Walker A motif; other site 868595000608 ATP binding site [chemical binding]; other site 868595000609 Walker B motif; other site 868595000610 arginine finger; other site 868595000611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595000612 Walker A motif; other site 868595000613 ATP binding site [chemical binding]; other site 868595000614 Walker B motif; other site 868595000615 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 868595000616 DNA repair protein RadA; Provisional; Region: PRK11823 868595000617 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 868595000618 Walker A motif/ATP binding site; other site 868595000619 ATP binding site [chemical binding]; other site 868595000620 Walker B motif; other site 868595000621 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 868595000622 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 868595000623 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 868595000624 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 868595000625 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 868595000626 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 868595000627 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 868595000628 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 868595000629 putative active site [active] 868595000630 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 868595000631 substrate binding site; other site 868595000632 dimer interface; other site 868595000633 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 868595000634 homotrimer interaction site [polypeptide binding]; other site 868595000635 zinc binding site [ion binding]; other site 868595000636 CDP-binding sites; other site 868595000637 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 868595000638 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 868595000639 active site 868595000640 HIGH motif; other site 868595000641 nucleotide binding site [chemical binding]; other site 868595000642 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 868595000643 KMSKS motif; other site 868595000644 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 868595000645 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 868595000646 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 868595000647 HIGH motif; other site 868595000648 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 868595000649 active site 868595000650 KMSKS motif; other site 868595000651 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 868595000652 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 868595000653 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 868595000654 trimer interface [polypeptide binding]; other site 868595000655 active site 868595000656 substrate binding site [chemical binding]; other site 868595000657 CoA binding site [chemical binding]; other site 868595000658 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 868595000659 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 868595000660 active site 868595000661 HIGH motif; other site 868595000662 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 868595000663 KMSKS motif; other site 868595000664 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 868595000665 tRNA binding surface [nucleotide binding]; other site 868595000666 anticodon binding site; other site 868595000667 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 868595000668 active site 868595000669 metal binding site [ion binding]; metal-binding site 868595000670 dimerization interface [polypeptide binding]; other site 868595000671 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 868595000672 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 868595000673 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 868595000674 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 868595000675 YacP-like NYN domain; Region: NYN_YacP; pfam05991 868595000676 RNA polymerase factor sigma-70; Validated; Region: PRK08295 868595000677 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595000678 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 868595000679 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 868595000680 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 868595000681 putative active site [active] 868595000682 putative NTP binding site [chemical binding]; other site 868595000683 putative nucleic acid binding site [nucleotide binding]; other site 868595000684 elongation factor Tu; Reviewed; Region: PRK00049 868595000685 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 868595000686 G1 box; other site 868595000687 GEF interaction site [polypeptide binding]; other site 868595000688 GTP/Mg2+ binding site [chemical binding]; other site 868595000689 Switch I region; other site 868595000690 G2 box; other site 868595000691 G3 box; other site 868595000692 Switch II region; other site 868595000693 G4 box; other site 868595000694 G5 box; other site 868595000695 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 868595000696 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 868595000697 Antibiotic Binding Site [chemical binding]; other site 868595000698 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 868595000699 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 868595000700 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 868595000701 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 868595000702 putative homodimer interface [polypeptide binding]; other site 868595000703 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 868595000704 heterodimer interface [polypeptide binding]; other site 868595000705 homodimer interface [polypeptide binding]; other site 868595000706 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 868595000707 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 868595000708 23S rRNA interface [nucleotide binding]; other site 868595000709 L7/L12 interface [polypeptide binding]; other site 868595000710 putative thiostrepton binding site; other site 868595000711 L25 interface [polypeptide binding]; other site 868595000712 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 868595000713 mRNA/rRNA interface [nucleotide binding]; other site 868595000714 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 868595000715 23S rRNA interface [nucleotide binding]; other site 868595000716 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 868595000717 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 868595000718 peripheral dimer interface [polypeptide binding]; other site 868595000719 core dimer interface [polypeptide binding]; other site 868595000720 L10 interface [polypeptide binding]; other site 868595000721 L11 interface [polypeptide binding]; other site 868595000722 putative EF-Tu interaction site [polypeptide binding]; other site 868595000723 putative EF-G interaction site [polypeptide binding]; other site 868595000724 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 868595000725 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 868595000726 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 868595000727 RPB1 interaction site [polypeptide binding]; other site 868595000728 RPB10 interaction site [polypeptide binding]; other site 868595000729 RPB11 interaction site [polypeptide binding]; other site 868595000730 RPB3 interaction site [polypeptide binding]; other site 868595000731 RPB12 interaction site [polypeptide binding]; other site 868595000732 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 868595000733 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 868595000734 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 868595000735 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 868595000736 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 868595000737 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 868595000738 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 868595000739 G-loop; other site 868595000740 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 868595000741 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 868595000742 DNA binding site [nucleotide binding] 868595000743 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 868595000744 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 868595000745 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 868595000746 S17 interaction site [polypeptide binding]; other site 868595000747 S8 interaction site; other site 868595000748 16S rRNA interaction site [nucleotide binding]; other site 868595000749 streptomycin interaction site [chemical binding]; other site 868595000750 23S rRNA interaction site [nucleotide binding]; other site 868595000751 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 868595000752 30S ribosomal protein S7; Validated; Region: PRK05302 868595000753 elongation factor G; Reviewed; Region: PRK00007 868595000754 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 868595000755 G1 box; other site 868595000756 putative GEF interaction site [polypeptide binding]; other site 868595000757 GTP/Mg2+ binding site [chemical binding]; other site 868595000758 Switch I region; other site 868595000759 G2 box; other site 868595000760 G3 box; other site 868595000761 Switch II region; other site 868595000762 G4 box; other site 868595000763 G5 box; other site 868595000764 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 868595000765 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 868595000766 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 868595000767 elongation factor Tu; Reviewed; Region: PRK00049 868595000768 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 868595000769 G1 box; other site 868595000770 GEF interaction site [polypeptide binding]; other site 868595000771 GTP/Mg2+ binding site [chemical binding]; other site 868595000772 Switch I region; other site 868595000773 G2 box; other site 868595000774 G3 box; other site 868595000775 Switch II region; other site 868595000776 G4 box; other site 868595000777 G5 box; other site 868595000778 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 868595000779 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 868595000780 Antibiotic Binding Site [chemical binding]; other site 868595000781 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 868595000782 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 868595000783 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 868595000784 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 868595000785 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 868595000786 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 868595000787 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 868595000788 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 868595000789 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 868595000790 putative translocon binding site; other site 868595000791 protein-rRNA interface [nucleotide binding]; other site 868595000792 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 868595000793 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 868595000794 G-X-X-G motif; other site 868595000795 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 868595000796 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 868595000797 23S rRNA interface [nucleotide binding]; other site 868595000798 5S rRNA interface [nucleotide binding]; other site 868595000799 putative antibiotic binding site [chemical binding]; other site 868595000800 L25 interface [polypeptide binding]; other site 868595000801 L27 interface [polypeptide binding]; other site 868595000802 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 868595000803 23S rRNA interface [nucleotide binding]; other site 868595000804 putative translocon interaction site; other site 868595000805 signal recognition particle (SRP54) interaction site; other site 868595000806 L23 interface [polypeptide binding]; other site 868595000807 trigger factor interaction site; other site 868595000808 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 868595000809 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 868595000810 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 868595000811 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 868595000812 RNA binding site [nucleotide binding]; other site 868595000813 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 868595000814 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 868595000815 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 868595000816 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 868595000817 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 868595000818 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 868595000819 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 868595000820 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 868595000821 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 868595000822 23S rRNA interface [nucleotide binding]; other site 868595000823 5S rRNA interface [nucleotide binding]; other site 868595000824 L27 interface [polypeptide binding]; other site 868595000825 L5 interface [polypeptide binding]; other site 868595000826 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 868595000827 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 868595000828 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 868595000829 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 868595000830 23S rRNA binding site [nucleotide binding]; other site 868595000831 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 868595000832 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 868595000833 SecY translocase; Region: SecY; pfam00344 868595000834 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 868595000835 active site 868595000836 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 868595000837 RNA binding site [nucleotide binding]; other site 868595000838 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 868595000839 rRNA binding site [nucleotide binding]; other site 868595000840 predicted 30S ribosome binding site; other site 868595000841 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 868595000842 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 868595000843 30S ribosomal protein S13; Region: bact_S13; TIGR03631 868595000844 30S ribosomal protein S11; Validated; Region: PRK05309 868595000845 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 868595000846 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 868595000847 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595000848 RNA binding surface [nucleotide binding]; other site 868595000849 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 868595000850 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 868595000851 alphaNTD homodimer interface [polypeptide binding]; other site 868595000852 alphaNTD - beta interaction site [polypeptide binding]; other site 868595000853 alphaNTD - beta' interaction site [polypeptide binding]; other site 868595000854 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 868595000855 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 868595000856 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 868595000857 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 868595000858 Walker A/P-loop; other site 868595000859 ATP binding site [chemical binding]; other site 868595000860 Q-loop/lid; other site 868595000861 ABC transporter signature motif; other site 868595000862 Walker B; other site 868595000863 D-loop; other site 868595000864 H-loop/switch region; other site 868595000865 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 868595000866 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 868595000867 Walker A/P-loop; other site 868595000868 ATP binding site [chemical binding]; other site 868595000869 Q-loop/lid; other site 868595000870 ABC transporter signature motif; other site 868595000871 Walker B; other site 868595000872 D-loop; other site 868595000873 H-loop/switch region; other site 868595000874 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 868595000875 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 868595000876 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 868595000877 dimerization interface 3.5A [polypeptide binding]; other site 868595000878 active site 868595000879 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 868595000880 23S rRNA interface [nucleotide binding]; other site 868595000881 L3 interface [polypeptide binding]; other site 868595000882 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 868595000883 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 868595000884 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 868595000885 active site 868595000886 metal binding site [ion binding]; metal-binding site 868595000887 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 868595000888 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 868595000889 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 868595000890 catalytic residue [active] 868595000891 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 868595000892 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 868595000893 LysE type translocator; Region: LysE; cl00565 868595000894 hypothetical protein; Provisional; Region: PRK03881 868595000895 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 868595000896 AMMECR1; Region: AMMECR1; pfam01871 868595000897 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 868595000898 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595000899 FeS/SAM binding site; other site 868595000900 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 868595000901 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 868595000902 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 868595000903 heterotetramer interface [polypeptide binding]; other site 868595000904 active site pocket [active] 868595000905 cleavage site 868595000906 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 868595000907 feedback inhibition sensing region; other site 868595000908 homohexameric interface [polypeptide binding]; other site 868595000909 nucleotide binding site [chemical binding]; other site 868595000910 N-acetyl-L-glutamate binding site [chemical binding]; other site 868595000911 acetylornithine aminotransferase; Provisional; Region: PRK02627 868595000912 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 868595000913 inhibitor-cofactor binding pocket; inhibition site 868595000914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595000915 catalytic residue [active] 868595000916 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 868595000917 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 868595000918 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 868595000919 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 868595000920 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 868595000921 ATP-grasp domain; Region: ATP-grasp_4; cl17255 868595000922 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 868595000923 substrate binding site [chemical binding]; other site 868595000924 ornithine carbamoyltransferase; Provisional; Region: PRK00779 868595000925 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 868595000926 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 868595000927 argininosuccinate synthase; Provisional; Region: PRK13820 868595000928 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 868595000929 ANP binding site [chemical binding]; other site 868595000930 Substrate Binding Site II [chemical binding]; other site 868595000931 Substrate Binding Site I [chemical binding]; other site 868595000932 argininosuccinate lyase; Provisional; Region: PRK00855 868595000933 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 868595000934 active sites [active] 868595000935 tetramer interface [polypeptide binding]; other site 868595000936 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 868595000937 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 868595000938 DNA binding residues [nucleotide binding] 868595000939 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 868595000940 catalytic residues [active] 868595000941 catalytic nucleophile [active] 868595000942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 868595000943 Probable transposase; Region: OrfB_IS605; pfam01385 868595000944 SWIM zinc finger; Region: SWIM; pfam04434 868595000945 Flagellin N-methylase; Region: FliB; pfam03692 868595000946 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 868595000947 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 868595000948 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 868595000949 PYR/PP interface [polypeptide binding]; other site 868595000950 dimer interface [polypeptide binding]; other site 868595000951 TPP binding site [chemical binding]; other site 868595000952 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 868595000953 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 868595000954 TPP-binding site [chemical binding]; other site 868595000955 dimer interface [polypeptide binding]; other site 868595000956 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 868595000957 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 868595000958 putative valine binding site [chemical binding]; other site 868595000959 dimer interface [polypeptide binding]; other site 868595000960 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 868595000961 ketol-acid reductoisomerase; Provisional; Region: PRK05479 868595000962 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 868595000963 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 868595000964 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 868595000965 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 868595000966 PYR/PP interface [polypeptide binding]; other site 868595000967 dimer interface [polypeptide binding]; other site 868595000968 TPP binding site [chemical binding]; other site 868595000969 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 868595000970 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 868595000971 TPP-binding site [chemical binding]; other site 868595000972 dimer interface [polypeptide binding]; other site 868595000973 2-isopropylmalate synthase; Validated; Region: PRK00915 868595000974 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 868595000975 active site 868595000976 catalytic residues [active] 868595000977 metal binding site [ion binding]; metal-binding site 868595000978 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 868595000979 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 868595000980 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 868595000981 substrate binding site [chemical binding]; other site 868595000982 ligand binding site [chemical binding]; other site 868595000983 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 868595000984 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 868595000985 substrate binding site [chemical binding]; other site 868595000986 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 868595000987 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 868595000988 tartrate dehydrogenase; Region: TTC; TIGR02089 868595000989 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 868595000990 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 868595000991 active site 868595000992 catalytic residues [active] 868595000993 metal binding site [ion binding]; metal-binding site 868595000994 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 868595000995 Uncharacterized conserved protein [Function unknown]; Region: COG1624 868595000996 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 868595000997 YbbR-like protein; Region: YbbR; pfam07949 868595000998 YbbR-like protein; Region: YbbR; pfam07949 868595000999 YbbR-like protein; Region: YbbR; pfam07949 868595001000 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 868595001001 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 868595001002 active site 868595001003 substrate binding site [chemical binding]; other site 868595001004 metal binding site [ion binding]; metal-binding site 868595001005 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 868595001006 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 868595001007 glutaminase active site [active] 868595001008 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 868595001009 dimer interface [polypeptide binding]; other site 868595001010 active site 868595001011 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 868595001012 dimer interface [polypeptide binding]; other site 868595001013 active site 868595001014 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 868595001015 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 868595001016 Methyltransferase domain; Region: Methyltransf_26; pfam13659 868595001017 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 868595001018 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 868595001019 HAS barrel domain; Region: HAS-barrel; pfam09378 868595001020 Domain of unknown function DUF87; Region: DUF87; pfam01935 868595001021 AAA-like domain; Region: AAA_10; pfam12846 868595001022 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 868595001023 Catalytic domain of Protein Kinases; Region: PKc; cd00180 868595001024 active site 868595001025 ATP binding site [chemical binding]; other site 868595001026 substrate binding site [chemical binding]; other site 868595001027 activation loop (A-loop); other site 868595001028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595001029 TPR motif; other site 868595001030 Tetratricopeptide repeat; Region: TPR_16; pfam13432 868595001031 binding surface 868595001032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 868595001033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 868595001034 Integrase core domain; Region: rve; pfam00665 868595001035 transposase/IS protein; Provisional; Region: PRK09183 868595001036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595001037 Walker A motif; other site 868595001038 ATP binding site [chemical binding]; other site 868595001039 Walker B motif; other site 868595001040 Uncharacterized conserved protein [Function unknown]; Region: COG1479 868595001041 Protein of unknown function DUF262; Region: DUF262; pfam03235 868595001042 Uncharacterized conserved protein [Function unknown]; Region: COG3472 868595001043 Catalytic GIY-YIG domain of coliphage T4 non-specific endonuclease II, type II restriction endonuclease R.Hpy188I, and similar proteins; Region: GIY-YIG_EndoII_Hpy188I_like; cd10436 868595001044 GIY-YIG motif/motif A; other site 868595001045 DNA binding site [nucleotide binding] 868595001046 active site 868595001047 catalytic site [active] 868595001048 metal binding site [ion binding]; metal-binding site 868595001049 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 868595001050 Predicted transcriptional regulators [Transcription]; Region: COG1733 868595001051 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595001052 dimerization interface [polypeptide binding]; other site 868595001053 putative DNA binding site [nucleotide binding]; other site 868595001054 putative Zn2+ binding site [ion binding]; other site 868595001055 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 868595001056 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 868595001057 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 868595001058 active site 868595001059 metal binding site [ion binding]; metal-binding site 868595001060 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 868595001061 dimer interface [polypeptide binding]; other site 868595001062 Alkaline phosphatase homologues; Region: alkPPc; smart00098 868595001063 active site 868595001064 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595001065 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 868595001066 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 868595001067 trimerization site [polypeptide binding]; other site 868595001068 active site 868595001069 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 868595001070 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 868595001071 active site 868595001072 metal binding site [ion binding]; metal-binding site 868595001073 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 868595001074 NodB motif; other site 868595001075 putative active site [active] 868595001076 putative catalytic site [active] 868595001077 Zn binding site [ion binding]; other site 868595001078 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 868595001079 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 868595001080 NodB motif; other site 868595001081 active site 868595001082 catalytic site [active] 868595001083 metal binding site [ion binding]; metal-binding site 868595001084 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 868595001085 HlyD family secretion protein; Region: HlyD_3; pfam13437 868595001086 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 868595001087 Protein export membrane protein; Region: SecD_SecF; cl14618 868595001088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001089 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 868595001090 DNA binding site [nucleotide binding] 868595001091 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 868595001092 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595001093 dimerization interface [polypeptide binding]; other site 868595001094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595001095 dimer interface [polypeptide binding]; other site 868595001096 phosphorylation site [posttranslational modification] 868595001097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595001098 ATP binding site [chemical binding]; other site 868595001099 Mg2+ binding site [ion binding]; other site 868595001100 G-X-G motif; other site 868595001101 Predicted membrane protein [Function unknown]; Region: COG3462 868595001102 Short C-terminal domain; Region: SHOCT; pfam09851 868595001103 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 868595001104 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 868595001105 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 868595001106 Ligand Binding Site [chemical binding]; other site 868595001107 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 868595001108 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 868595001109 active site 868595001110 Predicted permease; Region: DUF318; cl17795 868595001111 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 868595001112 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 868595001113 Walker A/P-loop; other site 868595001114 ATP binding site [chemical binding]; other site 868595001115 Q-loop/lid; other site 868595001116 ABC transporter signature motif; other site 868595001117 Walker B; other site 868595001118 D-loop; other site 868595001119 H-loop/switch region; other site 868595001120 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 868595001121 cobalt transport protein CbiN; Provisional; Region: PRK02898 868595001122 cobalt transport protein CbiM; Validated; Region: PRK08319 868595001123 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 868595001124 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 868595001125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 868595001126 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 868595001127 putative dimerization interface [polypeptide binding]; other site 868595001128 Predicted membrane protein [Function unknown]; Region: COG2855 868595001129 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 868595001130 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 868595001131 ligand binding site [chemical binding]; other site 868595001132 flexible hinge region; other site 868595001133 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 868595001134 putative switch regulator; other site 868595001135 non-specific DNA interactions [nucleotide binding]; other site 868595001136 DNA binding site [nucleotide binding] 868595001137 sequence specific DNA binding site [nucleotide binding]; other site 868595001138 putative cAMP binding site [chemical binding]; other site 868595001139 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 868595001140 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 868595001141 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 868595001142 NADH dehydrogenase subunit M; Validated; Region: PRK08668 868595001143 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 868595001144 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 868595001145 NADH dehydrogenase; Region: NADHdh; cl00469 868595001146 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 868595001147 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 868595001148 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595001149 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 868595001150 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 868595001151 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 868595001152 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 868595001153 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 868595001154 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 868595001155 4Fe-4S binding domain; Region: Fer4; cl02805 868595001156 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 868595001157 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 868595001158 ACS interaction site; other site 868595001159 CODH interaction site; other site 868595001160 cubane metal cluster (B-cluster) [ion binding]; other site 868595001161 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 868595001162 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 868595001163 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 868595001164 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 868595001165 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 868595001166 Acylphosphatase; Region: Acylphosphatase; pfam00708 868595001167 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 868595001168 HypF finger; Region: zf-HYPF; pfam07503 868595001169 HypF finger; Region: zf-HYPF; pfam07503 868595001170 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 868595001171 HupF/HypC family; Region: HupF_HypC; pfam01455 868595001172 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 868595001173 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 868595001174 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 868595001175 dimerization interface [polypeptide binding]; other site 868595001176 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 868595001177 ATP binding site [chemical binding]; other site 868595001178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595001179 dimer interface [polypeptide binding]; other site 868595001180 phosphorylation site [posttranslational modification] 868595001181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595001182 ATP binding site [chemical binding]; other site 868595001183 Mg2+ binding site [ion binding]; other site 868595001184 G-X-G motif; other site 868595001185 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595001186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001187 active site 868595001188 phosphorylation site [posttranslational modification] 868595001189 intermolecular recognition site; other site 868595001190 dimerization interface [polypeptide binding]; other site 868595001191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595001192 DNA binding site [nucleotide binding] 868595001193 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 868595001194 active site 868595001195 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 868595001196 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 868595001197 active site 868595001198 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 868595001199 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 868595001200 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 868595001201 active site 868595001202 dimer interfaces [polypeptide binding]; other site 868595001203 catalytic residues [active] 868595001204 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 868595001205 PhoU domain; Region: PhoU; pfam01895 868595001206 PhoU domain; Region: PhoU; pfam01895 868595001207 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 868595001208 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 868595001209 Walker A/P-loop; other site 868595001210 ATP binding site [chemical binding]; other site 868595001211 Q-loop/lid; other site 868595001212 ABC transporter signature motif; other site 868595001213 Walker B; other site 868595001214 D-loop; other site 868595001215 H-loop/switch region; other site 868595001216 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 868595001217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595001218 dimer interface [polypeptide binding]; other site 868595001219 conserved gate region; other site 868595001220 putative PBP binding loops; other site 868595001221 ABC-ATPase subunit interface; other site 868595001222 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 868595001223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595001224 dimer interface [polypeptide binding]; other site 868595001225 conserved gate region; other site 868595001226 putative PBP binding loops; other site 868595001227 ABC-ATPase subunit interface; other site 868595001228 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595001229 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 868595001230 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 868595001231 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 868595001232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 868595001233 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 868595001234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 868595001235 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 868595001236 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 868595001237 G1 box; other site 868595001238 putative GEF interaction site [polypeptide binding]; other site 868595001239 GTP/Mg2+ binding site [chemical binding]; other site 868595001240 Switch I region; other site 868595001241 G2 box; other site 868595001242 G3 box; other site 868595001243 Switch II region; other site 868595001244 G4 box; other site 868595001245 G5 box; other site 868595001246 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 868595001247 Predicted membrane protein [Function unknown]; Region: COG4905 868595001248 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 868595001249 Ligand binding site [chemical binding]; other site 868595001250 Electron transfer flavoprotein domain; Region: ETF; pfam01012 868595001251 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 868595001252 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 868595001253 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 868595001254 oxidoreductase; Provisional; Region: PRK10015 868595001255 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 868595001256 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 868595001257 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 868595001258 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 868595001259 tetramer interface [polypeptide binding]; other site 868595001260 catalytic Zn binding site [ion binding]; other site 868595001261 NADP binding site [chemical binding]; other site 868595001262 DsrE/DsrF-like family; Region: DrsE; cl00672 868595001263 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 868595001264 EamA-like transporter family; Region: EamA; pfam00892 868595001265 EamA-like transporter family; Region: EamA; pfam00892 868595001266 Transglycosylase; Region: Transgly; pfam00912 868595001267 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 868595001268 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 868595001269 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 868595001270 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 868595001271 active site 868595001272 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 868595001273 putative deacylase active site [active] 868595001274 FOG: CBS domain [General function prediction only]; Region: COG0517 868595001275 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 868595001276 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 868595001277 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595001278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001279 active site 868595001280 phosphorylation site [posttranslational modification] 868595001281 intermolecular recognition site; other site 868595001282 dimerization interface [polypeptide binding]; other site 868595001283 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595001284 DNA binding site [nucleotide binding] 868595001285 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 868595001286 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595001287 dimerization interface [polypeptide binding]; other site 868595001288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595001289 dimer interface [polypeptide binding]; other site 868595001290 phosphorylation site [posttranslational modification] 868595001291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595001292 ATP binding site [chemical binding]; other site 868595001293 Mg2+ binding site [ion binding]; other site 868595001294 G-X-G motif; other site 868595001295 Domain of unknown function DUF302; Region: DUF302; pfam03625 868595001296 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 868595001297 metal-binding site [ion binding] 868595001298 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 868595001299 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 868595001300 metal-binding site [ion binding] 868595001301 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 868595001302 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 868595001303 metal-binding site [ion binding] 868595001304 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 868595001305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 868595001306 motif II; other site 868595001307 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 868595001308 putative homodimer interface [polypeptide binding]; other site 868595001309 putative homotetramer interface [polypeptide binding]; other site 868595001310 allosteric switch controlling residues; other site 868595001311 putative metal binding site [ion binding]; other site 868595001312 putative homodimer-homodimer interface [polypeptide binding]; other site 868595001313 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 868595001314 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 868595001315 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 868595001316 putative AMP binding site [chemical binding]; other site 868595001317 putative active site [active] 868595001318 acyl-activating enzyme (AAE) consensus motif; other site 868595001319 putative CoA binding site [chemical binding]; other site 868595001320 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 868595001321 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 868595001322 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 868595001323 Walker A/P-loop; other site 868595001324 ATP binding site [chemical binding]; other site 868595001325 Q-loop/lid; other site 868595001326 ABC transporter signature motif; other site 868595001327 Walker B; other site 868595001328 D-loop; other site 868595001329 H-loop/switch region; other site 868595001330 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 868595001331 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 868595001332 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 868595001333 Walker A/P-loop; other site 868595001334 ATP binding site [chemical binding]; other site 868595001335 Q-loop/lid; other site 868595001336 ABC transporter signature motif; other site 868595001337 Walker B; other site 868595001338 D-loop; other site 868595001339 H-loop/switch region; other site 868595001340 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 868595001341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 868595001342 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 868595001343 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 868595001344 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 868595001345 lipoyl synthase; Provisional; Region: PRK05481 868595001346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595001347 FeS/SAM binding site; other site 868595001348 hypothetical protein; Provisional; Region: PHA02695; cl17648 868595001349 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 868595001350 dimer interface [polypeptide binding]; other site 868595001351 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 868595001352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595001353 dimer interface [polypeptide binding]; other site 868595001354 conserved gate region; other site 868595001355 putative PBP binding loops; other site 868595001356 ABC-ATPase subunit interface; other site 868595001357 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 868595001358 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 868595001359 Walker A/P-loop; other site 868595001360 ATP binding site [chemical binding]; other site 868595001361 Q-loop/lid; other site 868595001362 ABC transporter signature motif; other site 868595001363 Walker B; other site 868595001364 D-loop; other site 868595001365 H-loop/switch region; other site 868595001366 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 868595001367 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 868595001368 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 868595001369 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 868595001370 Transcriptional regulator PadR-like family; Region: PadR; cl17335 868595001371 Predicted transcriptional regulators [Transcription]; Region: COG1695 868595001372 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 868595001373 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 868595001374 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 868595001375 putative active site [active] 868595001376 putative CoA binding site [chemical binding]; other site 868595001377 nudix motif; other site 868595001378 metal binding site [ion binding]; metal-binding site 868595001379 hybrid cluster protein; Provisional; Region: PRK05290 868595001380 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 868595001381 ACS interaction site; other site 868595001382 CODH interaction site; other site 868595001383 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 868595001384 hybrid metal cluster; other site 868595001385 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 868595001386 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 868595001387 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 868595001388 FAD binding pocket [chemical binding]; other site 868595001389 FAD binding motif [chemical binding]; other site 868595001390 phosphate binding motif [ion binding]; other site 868595001391 beta-alpha-beta structure motif; other site 868595001392 NAD binding pocket [chemical binding]; other site 868595001393 Iron coordination center [ion binding]; other site 868595001394 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 868595001395 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 868595001396 4Fe-4S binding domain; Region: Fer4; pfam00037 868595001397 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 868595001398 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 868595001399 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 868595001400 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 868595001401 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 868595001402 trimer interface [polypeptide binding]; other site 868595001403 putative Zn binding site [ion binding]; other site 868595001404 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 868595001405 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 868595001406 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 868595001407 HlyD family secretion protein; Region: HlyD_3; pfam13437 868595001408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 868595001409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 868595001410 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 868595001411 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 868595001412 Aspartase; Region: Aspartase; cd01357 868595001413 active sites [active] 868595001414 tetramer interface [polypeptide binding]; other site 868595001415 hydroxylamine reductase; Provisional; Region: PRK12310 868595001416 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 868595001417 cubane metal cluster [ion binding]; other site 868595001418 hybrid metal cluster; other site 868595001419 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 868595001420 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 868595001421 putative active site [active] 868595001422 metal binding site [ion binding]; metal-binding site 868595001423 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 868595001424 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 868595001425 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 868595001426 Walker A/P-loop; other site 868595001427 ATP binding site [chemical binding]; other site 868595001428 Q-loop/lid; other site 868595001429 ABC transporter signature motif; other site 868595001430 Walker B; other site 868595001431 D-loop; other site 868595001432 H-loop/switch region; other site 868595001433 Ferredoxin [Energy production and conversion]; Region: COG1146 868595001434 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595001435 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 868595001436 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 868595001437 DNA binding residues [nucleotide binding] 868595001438 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 868595001439 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 868595001440 TM-ABC transporter signature motif; other site 868595001441 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 868595001442 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 868595001443 TM-ABC transporter signature motif; other site 868595001444 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 868595001445 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 868595001446 Walker A/P-loop; other site 868595001447 ATP binding site [chemical binding]; other site 868595001448 Q-loop/lid; other site 868595001449 ABC transporter signature motif; other site 868595001450 Walker B; other site 868595001451 D-loop; other site 868595001452 H-loop/switch region; other site 868595001453 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 868595001454 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 868595001455 Walker A/P-loop; other site 868595001456 ATP binding site [chemical binding]; other site 868595001457 Q-loop/lid; other site 868595001458 ABC transporter signature motif; other site 868595001459 Walker B; other site 868595001460 D-loop; other site 868595001461 H-loop/switch region; other site 868595001462 ferric uptake regulator; Provisional; Region: fur; PRK09462 868595001463 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 868595001464 metal binding site 2 [ion binding]; metal-binding site 868595001465 putative DNA binding helix; other site 868595001466 metal binding site 1 [ion binding]; metal-binding site 868595001467 dimer interface [polypeptide binding]; other site 868595001468 structural Zn2+ binding site [ion binding]; other site 868595001469 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 868595001470 Rubredoxin; Region: Rubredoxin; pfam00301 868595001471 iron binding site [ion binding]; other site 868595001472 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 868595001473 Rubrerythrin [Energy production and conversion]; Region: COG1592 868595001474 diiron binding motif [ion binding]; other site 868595001475 Hemerythrin; Region: Hemerythrin; cd12107 868595001476 Fe binding site [ion binding]; other site 868595001477 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 868595001478 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 868595001479 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 868595001480 HEAT-like repeat; Region: HEAT_EZ; pfam13513 868595001481 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 868595001482 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 868595001483 EamA-like transporter family; Region: EamA; pfam00892 868595001484 EamA-like transporter family; Region: EamA; pfam00892 868595001485 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 868595001486 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 868595001487 DNA binding site [nucleotide binding] 868595001488 active site 868595001489 S-layer homology domain; Region: SLH; pfam00395 868595001490 S-layer homology domain; Region: SLH; pfam00395 868595001491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 868595001492 sequence-specific DNA binding site [nucleotide binding]; other site 868595001493 salt bridge; other site 868595001494 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 868595001495 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 868595001496 FMN binding site [chemical binding]; other site 868595001497 substrate binding site [chemical binding]; other site 868595001498 putative catalytic residue [active] 868595001499 Cation transport protein; Region: TrkH; cl17365 868595001500 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 868595001501 TrkA-N domain; Region: TrkA_N; pfam02254 868595001502 TrkA-C domain; Region: TrkA_C; pfam02080 868595001503 TrkA-N domain; Region: TrkA_N; pfam02254 868595001504 TrkA-C domain; Region: TrkA_C; pfam02080 868595001505 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 868595001506 dimanganese center [ion binding]; other site 868595001507 CotJB protein; Region: CotJB; pfam12652 868595001508 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 868595001509 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 868595001510 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 868595001511 active site 868595001512 dimer interface [polypeptide binding]; other site 868595001513 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 868595001514 dimer interface [polypeptide binding]; other site 868595001515 active site 868595001516 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 868595001517 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 868595001518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 868595001519 Coenzyme A binding pocket [chemical binding]; other site 868595001520 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 868595001521 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 868595001522 putative valine binding site [chemical binding]; other site 868595001523 dimer interface [polypeptide binding]; other site 868595001524 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 868595001525 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 868595001526 PemK-like protein; Region: PemK; pfam02452 868595001527 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 868595001528 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 868595001529 catalytic triad [active] 868595001530 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 868595001531 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 868595001532 active site 868595001533 Response regulator receiver domain; Region: Response_reg; pfam00072 868595001534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001535 active site 868595001536 phosphorylation site [posttranslational modification] 868595001537 intermolecular recognition site; other site 868595001538 dimerization interface [polypeptide binding]; other site 868595001539 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 868595001540 thiamine phosphate binding site [chemical binding]; other site 868595001541 active site 868595001542 pyrophosphate binding site [ion binding]; other site 868595001543 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 868595001544 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 868595001545 thiamine monophosphate kinase; Provisional; Region: PRK05731 868595001546 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 868595001547 ATP binding site [chemical binding]; other site 868595001548 dimerization interface [polypeptide binding]; other site 868595001549 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 868595001550 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 868595001551 Glycoprotease family; Region: Peptidase_M22; pfam00814 868595001552 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 868595001553 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 868595001554 Coenzyme A binding pocket [chemical binding]; other site 868595001555 UGMP family protein; Validated; Region: PRK09604 868595001556 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 868595001557 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595001558 Radical SAM superfamily; Region: Radical_SAM; pfam04055 868595001559 FeS/SAM binding site; other site 868595001560 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 868595001561 Protein of unknown function (DUF512); Region: DUF512; pfam04459 868595001562 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 868595001563 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 868595001564 acyl-activating enzyme (AAE) consensus motif; other site 868595001565 AMP binding site [chemical binding]; other site 868595001566 active site 868595001567 CoA binding site [chemical binding]; other site 868595001568 ACT domain-containing protein [General function prediction only]; Region: COG4747 868595001569 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 868595001570 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 868595001571 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 868595001572 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 868595001573 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 868595001574 Putative zinc-finger; Region: zf-HC2; pfam13490 868595001575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595001576 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 868595001577 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595001578 FeS/SAM binding site; other site 868595001579 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 868595001580 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 868595001581 dimer interface [polypeptide binding]; other site 868595001582 putative functional site; other site 868595001583 putative MPT binding site; other site 868595001584 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 868595001585 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 868595001586 dimer interface [polypeptide binding]; other site 868595001587 putative functional site; other site 868595001588 putative MPT binding site; other site 868595001589 PBP superfamily domain; Region: PBP_like; pfam12727 868595001590 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 868595001591 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 868595001592 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 868595001593 MPT binding site; other site 868595001594 trimer interface [polypeptide binding]; other site 868595001595 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 868595001596 oligomerisation interface [polypeptide binding]; other site 868595001597 mobile loop; other site 868595001598 roof hairpin; other site 868595001599 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 868595001600 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 868595001601 ring oligomerisation interface [polypeptide binding]; other site 868595001602 ATP/Mg binding site [chemical binding]; other site 868595001603 stacking interactions; other site 868595001604 hinge regions; other site 868595001605 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 868595001606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595001607 putative substrate translocation pore; other site 868595001608 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 868595001609 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 868595001610 dimer interface [polypeptide binding]; other site 868595001611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595001612 catalytic residue [active] 868595001613 acetyl-CoA synthetase; Provisional; Region: PRK00174 868595001614 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 868595001615 active site 868595001616 CoA binding site [chemical binding]; other site 868595001617 acyl-activating enzyme (AAE) consensus motif; other site 868595001618 AMP binding site [chemical binding]; other site 868595001619 acetate binding site [chemical binding]; other site 868595001620 GAF domain; Region: GAF; pfam01590 868595001621 Histidine kinase; Region: His_kinase; pfam06580 868595001622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595001623 ATP binding site [chemical binding]; other site 868595001624 Mg2+ binding site [ion binding]; other site 868595001625 G-X-G motif; other site 868595001626 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 868595001627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001628 active site 868595001629 phosphorylation site [posttranslational modification] 868595001630 intermolecular recognition site; other site 868595001631 dimerization interface [polypeptide binding]; other site 868595001632 LytTr DNA-binding domain; Region: LytTR; smart00850 868595001633 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 868595001634 Uncharacterized conserved protein [Function unknown]; Region: COG0062 868595001635 putative carbohydrate kinase; Provisional; Region: PRK10565 868595001636 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 868595001637 putative substrate binding site [chemical binding]; other site 868595001638 putative ATP binding site [chemical binding]; other site 868595001639 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 868595001640 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 868595001641 hexamer interface [polypeptide binding]; other site 868595001642 ligand binding site [chemical binding]; other site 868595001643 putative active site [active] 868595001644 NAD(P) binding site [chemical binding]; other site 868595001645 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 868595001646 alanine racemase; Reviewed; Region: alr; PRK00053 868595001647 active site 868595001648 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 868595001649 dimer interface [polypeptide binding]; other site 868595001650 substrate binding site [chemical binding]; other site 868595001651 catalytic residues [active] 868595001652 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 868595001653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001654 active site 868595001655 phosphorylation site [posttranslational modification] 868595001656 intermolecular recognition site; other site 868595001657 dimerization interface [polypeptide binding]; other site 868595001658 ANTAR domain; Region: ANTAR; pfam03861 868595001659 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 868595001660 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 868595001661 active site 868595001662 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 868595001663 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 868595001664 active site 868595001665 metal binding site [ion binding]; metal-binding site 868595001666 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 868595001667 CHASE3 domain; Region: CHASE3; cl05000 868595001668 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 868595001669 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595001670 dimerization interface [polypeptide binding]; other site 868595001671 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595001672 dimer interface [polypeptide binding]; other site 868595001673 putative CheW interface [polypeptide binding]; other site 868595001674 PAS domain; Region: PAS; smart00091 868595001675 PAS fold; Region: PAS_4; pfam08448 868595001676 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 868595001677 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595001678 Zn2+ binding site [ion binding]; other site 868595001679 Mg2+ binding site [ion binding]; other site 868595001680 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 868595001681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595001682 Walker A motif; other site 868595001683 ATP binding site [chemical binding]; other site 868595001684 Walker B motif; other site 868595001685 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 868595001686 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 868595001687 catalytic residues [active] 868595001688 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 868595001689 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 868595001690 dimer interface [polypeptide binding]; other site 868595001691 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 868595001692 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 868595001693 putative active site [active] 868595001694 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595001695 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595001696 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 868595001697 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 868595001698 transmembrane helices; other site 868595001699 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 868595001700 active site 868595001701 homotetramer interface [polypeptide binding]; other site 868595001702 homodimer interface [polypeptide binding]; other site 868595001703 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 868595001704 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 868595001705 active site 868595001706 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 868595001707 active site 2 [active] 868595001708 active site 1 [active] 868595001709 hypothetical protein; Provisional; Region: PRK06851 868595001710 hypothetical protein; Provisional; Region: PRK06761 868595001711 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 868595001712 Na binding site [ion binding]; other site 868595001713 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 868595001714 Ligand Binding Site [chemical binding]; other site 868595001715 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 868595001716 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595001717 dimer interface [polypeptide binding]; other site 868595001718 putative CheW interface [polypeptide binding]; other site 868595001719 Cache domain; Region: Cache_1; pfam02743 868595001720 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 868595001721 active site 868595001722 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 868595001723 dimer interface [polypeptide binding]; other site 868595001724 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 868595001725 Ligand Binding Site [chemical binding]; other site 868595001726 Molecular Tunnel; other site 868595001727 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 868595001728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001729 active site 868595001730 phosphorylation site [posttranslational modification] 868595001731 intermolecular recognition site; other site 868595001732 dimerization interface [polypeptide binding]; other site 868595001733 ANTAR domain; Region: ANTAR; pfam03861 868595001734 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 868595001735 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 868595001736 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 868595001737 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 868595001738 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 868595001739 active site 868595001740 FMN binding site [chemical binding]; other site 868595001741 substrate binding site [chemical binding]; other site 868595001742 3Fe-4S cluster binding site [ion binding]; other site 868595001743 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 868595001744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001745 active site 868595001746 phosphorylation site [posttranslational modification] 868595001747 intermolecular recognition site; other site 868595001748 dimerization interface [polypeptide binding]; other site 868595001749 ANTAR domain; Region: ANTAR; pfam03861 868595001750 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 868595001751 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 868595001752 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 868595001753 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 868595001754 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 868595001755 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 868595001756 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 868595001757 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 868595001758 active site 868595001759 dimer interface [polypeptide binding]; other site 868595001760 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 868595001761 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 868595001762 active site 868595001763 FMN binding site [chemical binding]; other site 868595001764 substrate binding site [chemical binding]; other site 868595001765 3Fe-4S cluster binding site [ion binding]; other site 868595001766 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 868595001767 domain interface; other site 868595001768 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 868595001769 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 868595001770 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 868595001771 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 868595001772 Nitrogen regulatory protein P-II; Region: P-II; smart00938 868595001773 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 868595001774 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 868595001775 G1 box; other site 868595001776 GTP/Mg2+ binding site [chemical binding]; other site 868595001777 Switch I region; other site 868595001778 G2 box; other site 868595001779 Switch II region; other site 868595001780 G3 box; other site 868595001781 G4 box; other site 868595001782 G5 box; other site 868595001783 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 868595001784 Aspartase; Region: Aspartase; cd01357 868595001785 active sites [active] 868595001786 tetramer interface [polypeptide binding]; other site 868595001787 NAD synthetase; Provisional; Region: PRK13981 868595001788 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 868595001789 multimer interface [polypeptide binding]; other site 868595001790 active site 868595001791 catalytic triad [active] 868595001792 protein interface 1 [polypeptide binding]; other site 868595001793 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 868595001794 Ligand Binding Site [chemical binding]; other site 868595001795 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 868595001796 putative catalytic site [active] 868595001797 putative metal binding site [ion binding]; other site 868595001798 putative phosphate binding site [ion binding]; other site 868595001799 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 868595001800 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 868595001801 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 868595001802 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 868595001803 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 868595001804 dimer interface [polypeptide binding]; other site 868595001805 NAD binding site [chemical binding]; other site 868595001806 substrate binding site [chemical binding]; other site 868595001807 tetramer (dimer of dimers) interface [polypeptide binding]; other site 868595001808 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 868595001809 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 868595001810 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 868595001811 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 868595001812 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 868595001813 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 868595001814 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 868595001815 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 868595001816 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 868595001817 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 868595001818 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595001819 Winged helix-turn helix; Region: HTH_29; pfam13551 868595001820 DNA binding residues [nucleotide binding] 868595001821 Integrase core domain; Region: rve; pfam00665 868595001822 transposase; Provisional; Region: PRK06526 868595001823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595001824 Walker A motif; other site 868595001825 ATP binding site [chemical binding]; other site 868595001826 Walker B motif; other site 868595001827 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 868595001828 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 868595001829 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 868595001830 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 868595001831 Cupin domain; Region: Cupin_2; pfam07883 868595001832 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 868595001833 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 868595001834 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 868595001835 active site 868595001836 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 868595001837 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 868595001838 Na binding site [ion binding]; other site 868595001839 Protein of unknown function (DUF502); Region: DUF502; cl01107 868595001840 FOG: CBS domain [General function prediction only]; Region: COG0517 868595001841 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 868595001842 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 868595001843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595001844 active site 868595001845 phosphorylation site [posttranslational modification] 868595001846 intermolecular recognition site; other site 868595001847 dimerization interface [polypeptide binding]; other site 868595001848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595001849 Walker A motif; other site 868595001850 ATP binding site [chemical binding]; other site 868595001851 Walker B motif; other site 868595001852 arginine finger; other site 868595001853 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 868595001854 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 868595001855 HAMP domain; Region: HAMP; pfam00672 868595001856 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595001857 dimer interface [polypeptide binding]; other site 868595001858 phosphorylation site [posttranslational modification] 868595001859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595001860 ATP binding site [chemical binding]; other site 868595001861 Mg2+ binding site [ion binding]; other site 868595001862 G-X-G motif; other site 868595001863 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 868595001864 FOG: CBS domain [General function prediction only]; Region: COG0517 868595001865 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 868595001866 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 868595001867 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 868595001868 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 868595001869 PhoU domain; Region: PhoU; pfam01895 868595001870 PhoU domain; Region: PhoU; pfam01895 868595001871 Protein of unknown function DUF45; Region: DUF45; pfam01863 868595001872 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 868595001873 Na2 binding site [ion binding]; other site 868595001874 putative substrate binding site 1 [chemical binding]; other site 868595001875 Na binding site 1 [ion binding]; other site 868595001876 putative substrate binding site 2 [chemical binding]; other site 868595001877 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 868595001878 Zn binding site [ion binding]; other site 868595001879 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 868595001880 NlpC/P60 family; Region: NLPC_P60; pfam00877 868595001881 S-layer homology domain; Region: SLH; pfam00395 868595001882 S-layer homology domain; Region: SLH; pfam00395 868595001883 Bacterial Ig-like domain; Region: Big_5; pfam13205 868595001884 Sporulation and spore germination; Region: Germane; pfam10646 868595001885 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 868595001886 active site 868595001887 SAM binding site [chemical binding]; other site 868595001888 homodimer interface [polypeptide binding]; other site 868595001889 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 868595001890 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 868595001891 active site 868595001892 C-terminal domain interface [polypeptide binding]; other site 868595001893 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 868595001894 active site 868595001895 N-terminal domain interface [polypeptide binding]; other site 868595001896 Uncharacterized conserved protein [Function unknown]; Region: COG1739 868595001897 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 868595001898 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 868595001899 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 868595001900 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 868595001901 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 868595001902 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 868595001903 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 868595001904 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 868595001905 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 868595001906 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 868595001907 putative dimer interface [polypeptide binding]; other site 868595001908 active site pocket [active] 868595001909 putative cataytic base [active] 868595001910 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 868595001911 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 868595001912 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 868595001913 catalytic triad [active] 868595001914 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 868595001915 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 868595001916 active site 868595001917 putative homodimer interface [polypeptide binding]; other site 868595001918 SAM binding site [chemical binding]; other site 868595001919 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 868595001920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595001921 S-adenosylmethionine binding site [chemical binding]; other site 868595001922 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 868595001923 active site 868595001924 SAM binding site [chemical binding]; other site 868595001925 homodimer interface [polypeptide binding]; other site 868595001926 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 868595001927 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 868595001928 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 868595001929 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 868595001930 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 868595001931 active site 868595001932 SAM binding site [chemical binding]; other site 868595001933 homodimer interface [polypeptide binding]; other site 868595001934 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 868595001935 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 868595001936 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 868595001937 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 868595001938 putative active site [active] 868595001939 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 868595001940 Precorrin-8X methylmutase; Region: CbiC; pfam02570 868595001941 cobyric acid synthase; Provisional; Region: PRK00784 868595001942 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 868595001943 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 868595001944 catalytic triad [active] 868595001945 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 868595001946 cobalamin synthase; Reviewed; Region: cobS; PRK00235 868595001947 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 868595001948 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 868595001949 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 868595001950 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595001951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595001952 homodimer interface [polypeptide binding]; other site 868595001953 catalytic residue [active] 868595001954 Helix-turn-helix domain; Region: HTH_17; pfam12728 868595001955 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595001956 ATP binding site [chemical binding]; other site 868595001957 putative Mg++ binding site [ion binding]; other site 868595001958 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595001959 nucleotide binding region [chemical binding]; other site 868595001960 ATP-binding site [chemical binding]; other site 868595001961 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 868595001962 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 868595001963 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 868595001964 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 868595001965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 868595001966 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 868595001967 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 868595001968 B12 binding site [chemical binding]; other site 868595001969 heterodimer interface [polypeptide binding]; other site 868595001970 cobalt ligand [ion binding]; other site 868595001971 MutL protein; Region: MutL; pfam13941 868595001972 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 868595001973 substrate binding site [chemical binding]; other site 868595001974 B12 cofactor binding site [chemical binding]; other site 868595001975 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 868595001976 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 868595001977 methylaspartate ammonia-lyase; Region: B_methylAsp_ase; TIGR01502 868595001978 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 868595001979 dimer interface [polypeptide binding]; other site 868595001980 active site 868595001981 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 868595001982 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 868595001983 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 868595001984 ribonuclease PH; Reviewed; Region: rph; PRK00173 868595001985 Ribonuclease PH; Region: RNase_PH_bact; cd11362 868595001986 hexamer interface [polypeptide binding]; other site 868595001987 active site 868595001988 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 868595001989 active site 868595001990 dimerization interface [polypeptide binding]; other site 868595001991 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 868595001992 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 868595001993 active site 868595001994 metal binding site [ion binding]; metal-binding site 868595001995 homotetramer interface [polypeptide binding]; other site 868595001996 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 868595001997 Part of AAA domain; Region: AAA_19; pfam13245 868595001998 Family description; Region: UvrD_C_2; pfam13538 868595001999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595002000 Major Facilitator Superfamily; Region: MFS_1; pfam07690 868595002001 putative substrate translocation pore; other site 868595002002 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 868595002003 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 868595002004 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 868595002005 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 868595002006 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 868595002007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595002008 dimer interface [polypeptide binding]; other site 868595002009 conserved gate region; other site 868595002010 putative PBP binding loops; other site 868595002011 ABC-ATPase subunit interface; other site 868595002012 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 868595002013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595002014 dimer interface [polypeptide binding]; other site 868595002015 conserved gate region; other site 868595002016 putative PBP binding loops; other site 868595002017 ABC-ATPase subunit interface; other site 868595002018 transposase; Provisional; Region: PRK06526 868595002019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002020 Walker A motif; other site 868595002021 ATP binding site [chemical binding]; other site 868595002022 Walker B motif; other site 868595002023 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595002024 Winged helix-turn helix; Region: HTH_29; pfam13551 868595002025 DNA binding residues [nucleotide binding] 868595002026 Integrase core domain; Region: rve; pfam00665 868595002027 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 868595002028 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 868595002029 Walker A/P-loop; other site 868595002030 ATP binding site [chemical binding]; other site 868595002031 Q-loop/lid; other site 868595002032 ABC transporter signature motif; other site 868595002033 Walker B; other site 868595002034 D-loop; other site 868595002035 H-loop/switch region; other site 868595002036 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 868595002037 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 868595002038 Protein of unknown function (DUF917); Region: DUF917; pfam06032 868595002039 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 868595002040 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 868595002041 Sodium Bile acid symporter family; Region: SBF; cl17470 868595002042 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 868595002043 Part of AAA domain; Region: AAA_19; pfam13245 868595002044 PhoH-like protein; Region: PhoH; cl17668 868595002045 Family description; Region: UvrD_C_2; pfam13538 868595002046 Transposase; Region: HTH_Tnp_1; cl17663 868595002047 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595002048 ATP binding site [chemical binding]; other site 868595002049 putative Mg++ binding site [ion binding]; other site 868595002050 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595002051 nucleotide binding region [chemical binding]; other site 868595002052 ATP-binding site [chemical binding]; other site 868595002053 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 868595002054 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 868595002055 Integrase core domain; Region: rve; pfam00665 868595002056 Integrase core domain; Region: rve_3; pfam13683 868595002057 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 868595002058 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 868595002059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002060 Walker A motif; other site 868595002061 ATP binding site [chemical binding]; other site 868595002062 Walker B motif; other site 868595002063 arginine finger; other site 868595002064 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595002065 ATP binding site [chemical binding]; other site 868595002066 putative Mg++ binding site [ion binding]; other site 868595002067 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 868595002068 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595002069 nucleotide binding region [chemical binding]; other site 868595002070 ATP-binding site [chemical binding]; other site 868595002071 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 868595002072 DNA methylase; Region: N6_N4_Mtase; cl17433 868595002073 DNA methylase; Region: N6_N4_Mtase; cl17433 868595002074 DEAD-like helicases superfamily; Region: DEXDc; smart00487 868595002075 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 868595002076 ATP binding site [chemical binding]; other site 868595002077 putative Mg++ binding site [ion binding]; other site 868595002078 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 868595002079 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 868595002080 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 868595002081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 868595002082 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 868595002083 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 868595002084 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 868595002085 HTH domain; Region: HTH_11; cl17392 868595002086 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 868595002087 putative active site pocket [active] 868595002088 dimerization interface [polypeptide binding]; other site 868595002089 putative catalytic residue [active] 868595002090 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 868595002091 putative active site pocket [active] 868595002092 dimerization interface [polypeptide binding]; other site 868595002093 putative catalytic residue [active] 868595002094 SWIM zinc finger; Region: SWIM; pfam04434 868595002095 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 868595002096 Uncharacterized conserved protein [Function unknown]; Region: COG1479 868595002097 Protein of unknown function DUF262; Region: DUF262; pfam03235 868595002098 Uncharacterized conserved protein [Function unknown]; Region: COG3472 868595002099 TIGR02300 family protein; Region: FYDLN_acid 868595002100 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 868595002101 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 868595002102 metal ion-dependent adhesion site (MIDAS); other site 868595002103 Predicted transcriptional regulator [Transcription]; Region: COG2378 868595002104 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 868595002105 WYL domain; Region: WYL; pfam13280 868595002106 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 868595002107 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 868595002108 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 868595002109 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 868595002110 zinc binding site [ion binding]; other site 868595002111 putative ligand binding site [chemical binding]; other site 868595002112 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 868595002113 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 868595002114 TM-ABC transporter signature motif; other site 868595002115 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 868595002116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 868595002117 Walker A/P-loop; other site 868595002118 ATP binding site [chemical binding]; other site 868595002119 Q-loop/lid; other site 868595002120 ABC transporter signature motif; other site 868595002121 Walker B; other site 868595002122 D-loop; other site 868595002123 H-loop/switch region; other site 868595002124 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 868595002125 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 868595002126 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 868595002127 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595002128 metal binding site [ion binding]; metal-binding site 868595002129 active site 868595002130 I-site; other site 868595002131 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 868595002132 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595002133 Zn2+ binding site [ion binding]; other site 868595002134 Mg2+ binding site [ion binding]; other site 868595002135 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 868595002136 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 868595002137 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 868595002138 active site 868595002139 metal binding site [ion binding]; metal-binding site 868595002140 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 868595002141 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 868595002142 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 868595002143 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 868595002144 Domain of unknown function (DUF378); Region: DUF378; pfam04070 868595002145 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 868595002146 SirA-like protein; Region: SirA; pfam01206 868595002147 CPxP motif; other site 868595002148 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 868595002149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 868595002150 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 868595002151 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 868595002152 active site residue [active] 868595002153 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595002154 dimerization interface [polypeptide binding]; other site 868595002155 putative DNA binding site [nucleotide binding]; other site 868595002156 putative Zn2+ binding site [ion binding]; other site 868595002157 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 868595002158 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 868595002159 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 868595002160 active site 868595002161 metal binding site [ion binding]; metal-binding site 868595002162 DNA binding site [nucleotide binding] 868595002163 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 868595002164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 868595002165 Walker A/P-loop; other site 868595002166 ATP binding site [chemical binding]; other site 868595002167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 868595002168 ABC transporter signature motif; other site 868595002169 Walker B; other site 868595002170 D-loop; other site 868595002171 H-loop/switch region; other site 868595002172 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 868595002173 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 868595002174 trigger factor; Provisional; Region: tig; PRK01490 868595002175 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 868595002176 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 868595002177 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 868595002178 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 868595002179 oligomer interface [polypeptide binding]; other site 868595002180 active site residues [active] 868595002181 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 868595002182 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 868595002183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002184 Walker A motif; other site 868595002185 ATP binding site [chemical binding]; other site 868595002186 Walker B motif; other site 868595002187 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 868595002188 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 868595002189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002190 Walker A motif; other site 868595002191 ATP binding site [chemical binding]; other site 868595002192 Walker B motif; other site 868595002193 arginine finger; other site 868595002194 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 868595002195 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 868595002196 Found in ATP-dependent protease La (LON); Region: LON; smart00464 868595002197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002198 Walker A motif; other site 868595002199 ATP binding site [chemical binding]; other site 868595002200 Walker B motif; other site 868595002201 arginine finger; other site 868595002202 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 868595002203 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 868595002204 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 868595002205 G1 box; other site 868595002206 GTP/Mg2+ binding site [chemical binding]; other site 868595002207 Switch I region; other site 868595002208 G2 box; other site 868595002209 G3 box; other site 868595002210 Switch II region; other site 868595002211 G4 box; other site 868595002212 G5 box; other site 868595002213 Spore germination protein; Region: Spore_permease; cl17796 868595002214 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 868595002215 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 868595002216 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 868595002217 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 868595002218 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 868595002219 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 868595002220 Spore germination protein; Region: Spore_permease; cl17796 868595002221 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 868595002222 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 868595002223 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 868595002224 NMT1/THI5 like; Region: NMT1; pfam09084 868595002225 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 868595002226 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 868595002227 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 868595002228 HIGH motif; other site 868595002229 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 868595002230 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 868595002231 active site 868595002232 KMSKS motif; other site 868595002233 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 868595002234 tRNA binding surface [nucleotide binding]; other site 868595002235 anticodon binding site; other site 868595002236 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 868595002237 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 868595002238 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 868595002239 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 868595002240 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 868595002241 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 868595002242 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 868595002243 CoA binding domain; Region: CoA_binding; smart00881 868595002244 Maf-like protein; Reviewed; Region: PRK00078 868595002245 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 868595002246 active site 868595002247 dimer interface [polypeptide binding]; other site 868595002248 hypothetical protein; Reviewed; Region: PRK00024 868595002249 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 868595002250 helix-hairpin-helix signature motif; other site 868595002251 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 868595002252 MPN+ (JAMM) motif; other site 868595002253 Zinc-binding site [ion binding]; other site 868595002254 rod shape-determining protein MreB; Provisional; Region: PRK13927 868595002255 MreB and similar proteins; Region: MreB_like; cd10225 868595002256 nucleotide binding site [chemical binding]; other site 868595002257 Mg binding site [ion binding]; other site 868595002258 putative protofilament interaction site [polypeptide binding]; other site 868595002259 RodZ interaction site [polypeptide binding]; other site 868595002260 rod shape-determining protein MreC; Provisional; Region: PRK13922 868595002261 rod shape-determining protein MreC; Region: MreC; pfam04085 868595002262 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 868595002263 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 868595002264 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 868595002265 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 868595002266 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 868595002267 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 868595002268 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 868595002269 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 868595002270 Switch I; other site 868595002271 Switch II; other site 868595002272 Septum formation topological specificity factor MinE; Region: MinE; cl00538 868595002273 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 868595002274 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 868595002275 Peptidase family M23; Region: Peptidase_M23; pfam01551 868595002276 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 868595002277 active site 868595002278 putative substrate binding region [chemical binding]; other site 868595002279 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 868595002280 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595002281 FeS/SAM binding site; other site 868595002282 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 868595002283 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 868595002284 ribonuclease G; Provisional; Region: PRK11712 868595002285 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 868595002286 homodimer interface [polypeptide binding]; other site 868595002287 oligonucleotide binding site [chemical binding]; other site 868595002288 TRAM domain; Region: TRAM; cl01282 868595002289 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 868595002290 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 868595002291 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 868595002292 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 868595002293 GTPase CgtA; Reviewed; Region: obgE; PRK12297 868595002294 GTP1/OBG; Region: GTP1_OBG; pfam01018 868595002295 Obg GTPase; Region: Obg; cd01898 868595002296 G1 box; other site 868595002297 GTP/Mg2+ binding site [chemical binding]; other site 868595002298 Switch I region; other site 868595002299 G2 box; other site 868595002300 G3 box; other site 868595002301 Switch II region; other site 868595002302 G4 box; other site 868595002303 G5 box; other site 868595002304 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 868595002305 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 868595002306 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 868595002307 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 868595002308 Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040 868595002309 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 868595002310 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 868595002311 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 868595002312 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 868595002313 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 868595002314 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 868595002315 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 868595002316 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 868595002317 CRISPR-associated protein Cas4; Region: cas4; TIGR00372 868595002318 Archaeal protein of unknown function (DUF911); Region: DUF911; pfam06023 868595002319 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A; cl17680 868595002320 transposase/IS protein; Provisional; Region: PRK09183 868595002321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002322 Walker A motif; other site 868595002323 ATP binding site [chemical binding]; other site 868595002324 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 868595002325 Integrase core domain; Region: rve; pfam00665 868595002326 Helix-turn-helix domain; Region: HTH_28; pfam13518 868595002327 Winged helix-turn helix; Region: HTH_29; pfam13551 868595002328 Homeodomain-like domain; Region: HTH_32; pfam13565 868595002329 Integrase core domain; Region: rve; pfam00665 868595002330 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 868595002331 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 868595002332 putative ligand binding site [chemical binding]; other site 868595002333 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 868595002334 TM-ABC transporter signature motif; other site 868595002335 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 868595002336 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 868595002337 TM-ABC transporter signature motif; other site 868595002338 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 868595002339 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 868595002340 Walker A/P-loop; other site 868595002341 ATP binding site [chemical binding]; other site 868595002342 Q-loop/lid; other site 868595002343 ABC transporter signature motif; other site 868595002344 Walker B; other site 868595002345 D-loop; other site 868595002346 H-loop/switch region; other site 868595002347 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 868595002348 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 868595002349 Walker A/P-loop; other site 868595002350 ATP binding site [chemical binding]; other site 868595002351 Q-loop/lid; other site 868595002352 ABC transporter signature motif; other site 868595002353 Walker B; other site 868595002354 D-loop; other site 868595002355 H-loop/switch region; other site 868595002356 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 868595002357 alpha-gamma subunit interface [polypeptide binding]; other site 868595002358 beta-gamma subunit interface [polypeptide binding]; other site 868595002359 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 868595002360 gamma-beta subunit interface [polypeptide binding]; other site 868595002361 alpha-beta subunit interface [polypeptide binding]; other site 868595002362 urease subunit alpha; Reviewed; Region: ureC; PRK13207 868595002363 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 868595002364 subunit interactions [polypeptide binding]; other site 868595002365 active site 868595002366 flap region; other site 868595002367 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 868595002368 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 868595002369 dimer interface [polypeptide binding]; other site 868595002370 catalytic residues [active] 868595002371 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 868595002372 UreF; Region: UreF; pfam01730 868595002373 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 868595002374 UreD urease accessory protein; Region: UreD; cl00530 868595002375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 868595002376 Transposase; Region: DEDD_Tnp_IS110; pfam01548 868595002377 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 868595002378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 868595002379 Transposase; Region: HTH_Tnp_1; cl17663 868595002380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 868595002381 Integrase core domain; Region: rve; pfam00665 868595002382 Integrase core domain; Region: rve_3; pfam13683 868595002383 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 868595002384 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 868595002385 Transposase; Region: HTH_Tnp_1; pfam01527 868595002386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 868595002387 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 868595002388 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 868595002389 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 868595002390 fructuronate transporter; Provisional; Region: PRK10034; cl15264 868595002391 GntP family permease; Region: GntP_permease; pfam02447 868595002392 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 868595002393 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 868595002394 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 868595002395 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 868595002396 NAD binding site [chemical binding]; other site 868595002397 homodimer interface [polypeptide binding]; other site 868595002398 active site 868595002399 substrate binding site [chemical binding]; other site 868595002400 Predicted membrane protein [Function unknown]; Region: COG2246 868595002401 GtrA-like protein; Region: GtrA; pfam04138 868595002402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595002403 dimerization interface [polypeptide binding]; other site 868595002404 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595002405 dimer interface [polypeptide binding]; other site 868595002406 phosphorylation site [posttranslational modification] 868595002407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595002408 ATP binding site [chemical binding]; other site 868595002409 Mg2+ binding site [ion binding]; other site 868595002410 G-X-G motif; other site 868595002411 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595002412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595002413 active site 868595002414 phosphorylation site [posttranslational modification] 868595002415 intermolecular recognition site; other site 868595002416 dimerization interface [polypeptide binding]; other site 868595002417 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595002418 DNA binding site [nucleotide binding] 868595002419 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 868595002420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595002421 putative active site [active] 868595002422 heme pocket [chemical binding]; other site 868595002423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002424 Walker A motif; other site 868595002425 ATP binding site [chemical binding]; other site 868595002426 Walker B motif; other site 868595002427 arginine finger; other site 868595002428 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 868595002429 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 868595002430 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 868595002431 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 868595002432 tetramer interface [polypeptide binding]; other site 868595002433 TPP-binding site [chemical binding]; other site 868595002434 heterodimer interface [polypeptide binding]; other site 868595002435 phosphorylation loop region [posttranslational modification] 868595002436 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 868595002437 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 868595002438 alpha subunit interface [polypeptide binding]; other site 868595002439 TPP binding site [chemical binding]; other site 868595002440 heterodimer interface [polypeptide binding]; other site 868595002441 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 868595002442 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 868595002443 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 868595002444 lipoyl synthase; Provisional; Region: PRK05481 868595002445 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595002446 FeS/SAM binding site; other site 868595002447 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 868595002448 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 868595002449 E3 interaction surface; other site 868595002450 lipoyl attachment site [posttranslational modification]; other site 868595002451 e3 binding domain; Region: E3_binding; pfam02817 868595002452 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 868595002453 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 868595002454 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 868595002455 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 868595002456 dimer interface [polypeptide binding]; other site 868595002457 active site 868595002458 metal binding site [ion binding]; metal-binding site 868595002459 glutathione binding site [chemical binding]; other site 868595002460 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 868595002461 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595002462 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 868595002463 intersubunit interface [polypeptide binding]; other site 868595002464 active site 868595002465 catalytic residue [active] 868595002466 H+ Antiporter protein; Region: 2A0121; TIGR00900 868595002467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595002468 putative substrate translocation pore; other site 868595002469 heat shock protein HtpX; Provisional; Region: PRK03982 868595002470 Protein of unknown function (DUF503); Region: DUF503; pfam04456 868595002471 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 868595002472 Uncharacterized conserved protein [Function unknown]; Region: COG2006 868595002473 4Fe-4S binding domain; Region: Fer4; cl02805 868595002474 4Fe-4S binding domain; Region: Fer4; pfam00037 868595002475 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 868595002476 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 868595002477 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 868595002478 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 868595002479 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 868595002480 putative dimer interface [polypeptide binding]; other site 868595002481 putative anticodon binding site; other site 868595002482 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 868595002483 homodimer interface [polypeptide binding]; other site 868595002484 motif 1; other site 868595002485 motif 2; other site 868595002486 active site 868595002487 motif 3; other site 868595002488 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 868595002489 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 868595002490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595002491 FeS/SAM binding site; other site 868595002492 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 868595002493 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 868595002494 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 868595002495 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 868595002496 Cation efflux family; Region: Cation_efflux; pfam01545 868595002497 BON domain; Region: BON; pfam04972 868595002498 BON domain; Region: BON; pfam04972 868595002499 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 868595002500 metal binding site 2 [ion binding]; metal-binding site 868595002501 putative DNA binding helix; other site 868595002502 metal binding site 1 [ion binding]; metal-binding site 868595002503 dimer interface [polypeptide binding]; other site 868595002504 structural Zn2+ binding site [ion binding]; other site 868595002505 sensory histidine kinase AtoS; Provisional; Region: PRK11360 868595002506 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595002507 putative active site [active] 868595002508 heme pocket [chemical binding]; other site 868595002509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595002510 dimer interface [polypeptide binding]; other site 868595002511 phosphorylation site [posttranslational modification] 868595002512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595002513 ATP binding site [chemical binding]; other site 868595002514 Mg2+ binding site [ion binding]; other site 868595002515 G-X-G motif; other site 868595002516 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 868595002517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595002518 active site 868595002519 phosphorylation site [posttranslational modification] 868595002520 intermolecular recognition site; other site 868595002521 dimerization interface [polypeptide binding]; other site 868595002522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002523 Walker A motif; other site 868595002524 ATP binding site [chemical binding]; other site 868595002525 Walker B motif; other site 868595002526 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 868595002527 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 868595002528 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 868595002529 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 868595002530 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 868595002531 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 868595002532 uracil transporter; Provisional; Region: PRK10720 868595002533 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595002534 active site 868595002535 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 868595002536 catalytic residues [active] 868595002537 Protein of unknown function (DUF552); Region: DUF552; pfam04472 868595002538 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 868595002539 TIGR00269 family protein; Region: TIGR00269 868595002540 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 868595002541 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 868595002542 substrate binding site [chemical binding]; other site 868595002543 multimerization interface [polypeptide binding]; other site 868595002544 ATP binding site [chemical binding]; other site 868595002545 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 868595002546 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 868595002547 Cysteine-rich domain; Region: CCG; pfam02754 868595002548 Cysteine-rich domain; Region: CCG; pfam02754 868595002549 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595002550 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 868595002551 4Fe-4S binding domain; Region: Fer4; cl02805 868595002552 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 868595002553 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 868595002554 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 868595002555 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595002556 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595002557 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 868595002558 4Fe-4S binding domain; Region: Fer4; pfam00037 868595002559 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 868595002560 FAD dependent oxidoreductase; Region: DAO; pfam01266 868595002561 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 868595002562 4Fe-4S binding domain; Region: Fer4; pfam00037 868595002563 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 868595002564 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595002565 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 868595002566 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 868595002567 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 868595002568 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 868595002569 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 868595002570 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 868595002571 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 868595002572 Chromate transporter; Region: Chromate_transp; pfam02417 868595002573 Transcriptional regulators [Transcription]; Region: GntR; COG1802 868595002574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 868595002575 DNA-binding site [nucleotide binding]; DNA binding site 868595002576 FCD domain; Region: FCD; pfam07729 868595002577 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 868595002578 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 868595002579 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 868595002580 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 868595002581 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 868595002582 Walker A motif; other site 868595002583 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 868595002584 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 868595002585 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 868595002586 P loop nucleotide binding; other site 868595002587 switch II; other site 868595002588 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 868595002589 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 868595002590 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 868595002591 switch II; other site 868595002592 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 868595002593 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 868595002594 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 868595002595 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 868595002596 dimerization interface [polypeptide binding]; other site 868595002597 domain crossover interface; other site 868595002598 redox-dependent activation switch; other site 868595002599 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 868595002600 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 868595002601 putative [4Fe-4S] binding site [ion binding]; other site 868595002602 putative molybdopterin cofactor binding site [chemical binding]; other site 868595002603 Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568 868595002604 molybdopterin cofactor binding site; other site 868595002605 hypothetical protein; Provisional; Region: PRK03636 868595002606 UPF0302 domain; Region: UPF0302; pfam08864 868595002607 A short protein domain of unknown function; Region: IDEAL; smart00914 868595002608 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 868595002609 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 868595002610 RNA binding surface [nucleotide binding]; other site 868595002611 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 868595002612 active site 868595002613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595002614 Major Facilitator Superfamily; Region: MFS_1; pfam07690 868595002615 putative substrate translocation pore; other site 868595002616 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 868595002617 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 868595002618 putative active site [active] 868595002619 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 868595002620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595002621 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595002622 DNA binding residues [nucleotide binding] 868595002623 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 868595002624 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 868595002625 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 868595002626 Walker A/P-loop; other site 868595002627 ATP binding site [chemical binding]; other site 868595002628 Q-loop/lid; other site 868595002629 ABC transporter signature motif; other site 868595002630 Walker B; other site 868595002631 D-loop; other site 868595002632 H-loop/switch region; other site 868595002633 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595002634 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595002635 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 868595002636 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 868595002637 AAA domain; Region: AAA_32; pfam13654 868595002638 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 868595002639 ATP-dependent protease Lon; Provisional; Region: PRK13765 868595002640 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 868595002641 Uncharacterized conserved protein [Function unknown]; Region: COG1284 868595002642 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 868595002643 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 868595002644 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 868595002645 Transposase domain (DUF772); Region: DUF772; pfam05598 868595002646 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595002647 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 868595002648 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 868595002649 TIGR04076 family protein; Region: TIGR04076 868595002650 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 868595002651 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595002652 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 868595002653 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 868595002654 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 868595002655 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 868595002656 VanW like protein; Region: VanW; pfam04294 868595002657 G5 domain; Region: G5; pfam07501 868595002658 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 868595002659 PRC-barrel domain; Region: PRC; pfam05239 868595002660 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 868595002661 putative homodimer interface [polypeptide binding]; other site 868595002662 putative active site pocket [active] 868595002663 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 868595002664 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 868595002665 Cell division protein FtsA; Region: FtsA; smart00842 868595002666 Cell division protein FtsA; Region: FtsA; pfam14450 868595002667 Ubiquitin-like proteins; Region: UBQ; cl00155 868595002668 charged pocket; other site 868595002669 hydrophobic patch; other site 868595002670 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 868595002671 PBP superfamily domain; Region: PBP_like_2; pfam12849 868595002672 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 868595002673 Transposase domain (DUF772); Region: DUF772; pfam05598 868595002674 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595002675 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 868595002676 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 868595002677 FAD binding domain; Region: FAD_binding_4; pfam01565 868595002678 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 868595002679 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 868595002680 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 868595002681 Cysteine-rich domain; Region: CCG; pfam02754 868595002682 Cysteine-rich domain; Region: CCG; pfam02754 868595002683 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595002684 dimerization interface [polypeptide binding]; other site 868595002685 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 868595002686 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595002687 dimer interface [polypeptide binding]; other site 868595002688 putative CheW interface [polypeptide binding]; other site 868595002689 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595002690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595002691 active site 868595002692 phosphorylation site [posttranslational modification] 868595002693 intermolecular recognition site; other site 868595002694 dimerization interface [polypeptide binding]; other site 868595002695 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595002696 DNA binding site [nucleotide binding] 868595002697 PBP superfamily domain; Region: PBP_like_2; cl17296 868595002698 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 868595002699 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 868595002700 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 868595002701 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 868595002702 Walker A/P-loop; other site 868595002703 ATP binding site [chemical binding]; other site 868595002704 Q-loop/lid; other site 868595002705 ABC transporter signature motif; other site 868595002706 Walker B; other site 868595002707 D-loop; other site 868595002708 H-loop/switch region; other site 868595002709 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 868595002710 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 868595002711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595002712 dimer interface [polypeptide binding]; other site 868595002713 conserved gate region; other site 868595002714 putative PBP binding loops; other site 868595002715 ABC-ATPase subunit interface; other site 868595002716 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 868595002717 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 868595002718 substrate binding pocket [chemical binding]; other site 868595002719 membrane-bound complex binding site; other site 868595002720 hinge residues; other site 868595002721 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 868595002722 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 868595002723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595002724 catalytic residue [active] 868595002725 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 868595002726 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 868595002727 active site 868595002728 Methyltransferase domain; Region: Methyltransf_23; pfam13489 868595002729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595002730 S-adenosylmethionine binding site [chemical binding]; other site 868595002731 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 868595002732 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 868595002733 Probable Catalytic site; other site 868595002734 metal-binding site 868595002735 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 868595002736 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 868595002737 substrate binding site; other site 868595002738 metal-binding site 868595002739 Oligomer interface; other site 868595002740 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 868595002741 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 868595002742 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 868595002743 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 868595002744 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 868595002745 Probable Catalytic site; other site 868595002746 metal-binding site 868595002747 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 868595002748 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 868595002749 Probable Catalytic site; other site 868595002750 metal-binding site 868595002751 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 868595002752 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 868595002753 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 868595002754 NADP binding site [chemical binding]; other site 868595002755 active site 868595002756 putative substrate binding site [chemical binding]; other site 868595002757 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 868595002758 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 868595002759 NAD binding site [chemical binding]; other site 868595002760 substrate binding site [chemical binding]; other site 868595002761 homodimer interface [polypeptide binding]; other site 868595002762 active site 868595002763 Methyltransferase domain; Region: Methyltransf_23; pfam13489 868595002764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595002765 S-adenosylmethionine binding site [chemical binding]; other site 868595002766 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 868595002767 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 868595002768 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 868595002769 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 868595002770 Probable Catalytic site; other site 868595002771 metal-binding site 868595002772 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 868595002773 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 868595002774 putative metal binding site; other site 868595002775 Tetratricopeptide repeat; Region: TPR_12; pfam13424 868595002776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595002777 binding surface 868595002778 TPR motif; other site 868595002779 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 868595002780 putative metal binding site; other site 868595002781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595002782 binding surface 868595002783 TPR motif; other site 868595002784 Tetratricopeptide repeat; Region: TPR_12; pfam13424 868595002785 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 868595002786 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 868595002787 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 868595002788 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 868595002789 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 868595002790 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 868595002791 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 868595002792 active site 868595002793 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 868595002794 putative metal binding site; other site 868595002795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595002796 TPR motif; other site 868595002797 binding surface 868595002798 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 868595002799 putative metal binding site; other site 868595002800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595002801 binding surface 868595002802 TPR motif; other site 868595002803 Tetratricopeptide repeat; Region: TPR_12; pfam13424 868595002804 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 868595002805 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 868595002806 putative metal binding site; other site 868595002807 Tetratricopeptide repeat; Region: TPR_12; pfam13424 868595002808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595002809 binding surface 868595002810 TPR motif; other site 868595002811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 868595002812 binding surface 868595002813 TPR motif; other site 868595002814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595002815 TPR motif; other site 868595002816 binding surface 868595002817 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 868595002818 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 868595002819 YmaF family; Region: YmaF; pfam12788 868595002820 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 868595002821 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 868595002822 homodimer interface [polypeptide binding]; other site 868595002823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595002824 catalytic residue [active] 868595002825 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 868595002826 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 868595002827 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 868595002828 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 868595002829 Family description; Region: UvrD_C_2; pfam13538 868595002830 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 868595002831 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 868595002832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002833 Walker A motif; other site 868595002834 ATP binding site [chemical binding]; other site 868595002835 Walker B motif; other site 868595002836 arginine finger; other site 868595002837 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 868595002838 metal ion-dependent adhesion site (MIDAS); other site 868595002839 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595002840 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 868595002841 recombination factor protein RarA; Reviewed; Region: PRK13342 868595002842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595002843 Walker A motif; other site 868595002844 ATP binding site [chemical binding]; other site 868595002845 Walker B motif; other site 868595002846 arginine finger; other site 868595002847 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 868595002848 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 868595002849 heme-binding site [chemical binding]; other site 868595002850 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595002851 dimer interface [polypeptide binding]; other site 868595002852 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 868595002853 putative CheW interface [polypeptide binding]; other site 868595002854 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 868595002855 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 868595002856 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 868595002857 ABC transporter; Region: ABC_tran_2; pfam12848 868595002858 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 868595002859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595002860 S-adenosylmethionine binding site [chemical binding]; other site 868595002861 Ion channel; Region: Ion_trans_2; pfam07885 868595002862 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 868595002863 TrkA-N domain; Region: TrkA_N; pfam02254 868595002864 TrkA-C domain; Region: TrkA_C; pfam02080 868595002865 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 868595002866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595002867 dimerization interface [polypeptide binding]; other site 868595002868 putative DNA binding site [nucleotide binding]; other site 868595002869 putative Zn2+ binding site [ion binding]; other site 868595002870 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 868595002871 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 868595002872 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 868595002873 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 868595002874 Probable Catalytic site; other site 868595002875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 868595002876 Probable transposase; Region: OrfB_IS605; pfam01385 868595002877 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 868595002878 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 868595002879 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595002880 FeS/SAM binding site; other site 868595002881 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 868595002882 Uncharacterized conserved protein [Function unknown]; Region: COG0398 868595002883 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 868595002884 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 868595002885 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 868595002886 active site residue [active] 868595002887 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 868595002888 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 868595002889 GIY-YIG motif/motif A; other site 868595002890 putative active site [active] 868595002891 putative metal binding site [ion binding]; other site 868595002892 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 868595002893 flavoprotein, HI0933 family; Region: TIGR00275 868595002894 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 868595002895 Predicted membrane protein [Function unknown]; Region: COG4129 868595002896 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 868595002897 4Fe-4S binding domain; Region: Fer4; cl02805 868595002898 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595002899 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 868595002900 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 868595002901 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 868595002902 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595002903 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595002904 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595002905 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 868595002906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 868595002907 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 868595002908 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 868595002909 putative dimerization interface [polypeptide binding]; other site 868595002910 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 868595002911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595002912 S-adenosylmethionine binding site [chemical binding]; other site 868595002913 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 868595002914 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 868595002915 Cysteine-rich domain; Region: CCG; pfam02754 868595002916 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 868595002917 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 868595002918 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 868595002919 catalytic residue [active] 868595002920 putative FPP diphosphate binding site; other site 868595002921 putative FPP binding hydrophobic cleft; other site 868595002922 dimer interface [polypeptide binding]; other site 868595002923 putative IPP diphosphate binding site; other site 868595002924 glycogen branching enzyme; Provisional; Region: PRK12313 868595002925 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 868595002926 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 868595002927 active site 868595002928 catalytic site [active] 868595002929 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 868595002930 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 868595002931 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 868595002932 ligand binding site; other site 868595002933 oligomer interface; other site 868595002934 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 868595002935 N-terminal domain interface [polypeptide binding]; other site 868595002936 sulfate 1 binding site; other site 868595002937 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 868595002938 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 868595002939 ligand binding site; other site 868595002940 oligomer interface; other site 868595002941 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 868595002942 dimer interface [polypeptide binding]; other site 868595002943 N-terminal domain interface [polypeptide binding]; other site 868595002944 sulfate 1 binding site; other site 868595002945 glycogen synthase; Provisional; Region: glgA; PRK00654 868595002946 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 868595002947 ADP-binding pocket [chemical binding]; other site 868595002948 homodimer interface [polypeptide binding]; other site 868595002949 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 868595002950 homodimer interface [polypeptide binding]; other site 868595002951 maltodextrin glucosidase; Provisional; Region: PRK10785 868595002952 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 868595002953 active site 868595002954 homodimer interface [polypeptide binding]; other site 868595002955 catalytic site [active] 868595002956 4-alpha-glucanotransferase; Provisional; Region: PRK14508 868595002957 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 868595002958 benzoate transport; Region: 2A0115; TIGR00895 868595002959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595002960 putative substrate translocation pore; other site 868595002961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595002962 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 868595002963 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 868595002964 prephenate dehydratase; Provisional; Region: PRK11898 868595002965 Prephenate dehydratase; Region: PDT; pfam00800 868595002966 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 868595002967 putative L-Phe binding site [chemical binding]; other site 868595002968 Chorismate mutase type II; Region: CM_2; smart00830 868595002969 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 868595002970 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 868595002971 stage V sporulation protein AD; Provisional; Region: PRK12404 868595002972 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 868595002973 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 868595002974 Predicted membrane protein [Function unknown]; Region: COG2323 868595002975 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 868595002976 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 868595002977 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 868595002978 Predicted membrane protein [Function unknown]; Region: COG2323 868595002979 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 868595002980 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 868595002981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595002982 active site 868595002983 phosphorylation site [posttranslational modification] 868595002984 intermolecular recognition site; other site 868595002985 dimerization interface [polypeptide binding]; other site 868595002986 LytTr DNA-binding domain; Region: LytTR; pfam04397 868595002987 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 868595002988 Carbon starvation protein CstA; Region: CstA; pfam02554 868595002989 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 868595002990 heat shock protein 90; Provisional; Region: PRK05218 868595002991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595002992 ATP binding site [chemical binding]; other site 868595002993 Mg2+ binding site [ion binding]; other site 868595002994 G-X-G motif; other site 868595002995 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 868595002996 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 868595002997 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 868595002998 ligand binding site [chemical binding]; other site 868595002999 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 868595003000 putative ADP-ribose binding site [chemical binding]; other site 868595003001 putative active site [active] 868595003002 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 868595003003 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 868595003004 DRTGG domain; Region: DRTGG; pfam07085 868595003005 DHH family; Region: DHH; pfam01368 868595003006 DHHA2 domain; Region: DHHA2; pfam02833 868595003007 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 868595003008 thiosulfate reductase PhsA; Provisional; Region: PRK15488 868595003009 putative [Fe4-S4] binding site [ion binding]; other site 868595003010 putative molybdopterin cofactor binding site [chemical binding]; other site 868595003011 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 868595003012 putative molybdopterin cofactor binding site; other site 868595003013 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 868595003014 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 868595003015 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 868595003016 hydrogenase 4 subunit H; Validated; Region: PRK08222 868595003017 4Fe-4S binding domain; Region: Fer4; pfam00037 868595003018 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 868595003019 transaminase; Validated; Region: PRK07324 868595003020 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595003021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595003022 homodimer interface [polypeptide binding]; other site 868595003023 catalytic residue [active] 868595003024 YkyB-like protein; Region: YkyB; pfam14177 868595003025 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 868595003026 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 868595003027 dimerization interface 3.5A [polypeptide binding]; other site 868595003028 active site 868595003029 NAD-dependent deacetylase; Provisional; Region: PRK00481 868595003030 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 868595003031 YwiC-like protein; Region: YwiC; pfam14256 868595003032 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 868595003033 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 868595003034 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 868595003035 active site 868595003036 FMN binding site [chemical binding]; other site 868595003037 substrate binding site [chemical binding]; other site 868595003038 homotetramer interface [polypeptide binding]; other site 868595003039 catalytic residue [active] 868595003040 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595003041 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595003042 dimerization interface [polypeptide binding]; other site 868595003043 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 868595003044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595003045 dimer interface [polypeptide binding]; other site 868595003046 phosphorylation site [posttranslational modification] 868595003047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595003048 ATP binding site [chemical binding]; other site 868595003049 Mg2+ binding site [ion binding]; other site 868595003050 G-X-G motif; other site 868595003051 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 868595003052 butyrate kinase; Provisional; Region: PRK03011 868595003053 FIST N domain; Region: FIST; pfam08495 868595003054 FIST C domain; Region: FIST_C; pfam10442 868595003055 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595003056 Winged helix-turn helix; Region: HTH_29; pfam13551 868595003057 DNA binding residues [nucleotide binding] 868595003058 Integrase core domain; Region: rve; pfam00665 868595003059 transposase; Provisional; Region: PRK06526 868595003060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595003061 Walker A motif; other site 868595003062 ATP binding site [chemical binding]; other site 868595003063 Walker B motif; other site 868595003064 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 868595003065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 868595003066 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 868595003067 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 868595003068 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 868595003069 Predicted permeases [General function prediction only]; Region: COG0701 868595003070 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 868595003071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595003072 FeS/SAM binding site; other site 868595003073 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 868595003074 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 868595003075 arsenical-resistance protein; Region: acr3; TIGR00832 868595003076 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595003077 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595003078 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595003079 putative DNA binding site [nucleotide binding]; other site 868595003080 dimerization interface [polypeptide binding]; other site 868595003081 putative Zn2+ binding site [ion binding]; other site 868595003082 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 868595003083 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 868595003084 active site 868595003085 metal binding site [ion binding]; metal-binding site 868595003086 homotetramer interface [polypeptide binding]; other site 868595003087 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595003088 dimerization interface [polypeptide binding]; other site 868595003089 putative DNA binding site [nucleotide binding]; other site 868595003090 putative Zn2+ binding site [ion binding]; other site 868595003091 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595003092 dimerization interface [polypeptide binding]; other site 868595003093 putative DNA binding site [nucleotide binding]; other site 868595003094 putative Zn2+ binding site [ion binding]; other site 868595003095 Methyltransferase domain; Region: Methyltransf_31; pfam13847 868595003096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595003097 S-adenosylmethionine binding site [chemical binding]; other site 868595003098 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 868595003099 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 868595003100 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 868595003101 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 868595003102 catalytic loop [active] 868595003103 iron binding site [ion binding]; other site 868595003104 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 868595003105 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595003106 4Fe-4S binding domain; Region: Fer4; pfam00037 868595003107 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595003108 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 868595003109 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 868595003110 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 868595003111 catalytic loop [active] 868595003112 iron binding site [ion binding]; other site 868595003113 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 868595003114 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 868595003115 [4Fe-4S] binding site [ion binding]; other site 868595003116 molybdopterin cofactor binding site; other site 868595003117 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 868595003118 molybdopterin cofactor binding site; other site 868595003119 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 868595003120 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 868595003121 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595003122 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595003123 Putative Fe-S cluster; Region: FeS; cl17515 868595003124 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595003125 PAS domain; Region: PAS_9; pfam13426 868595003126 putative active site [active] 868595003127 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 868595003128 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 868595003129 N-acetyl-D-glucosamine binding site [chemical binding]; other site 868595003130 catalytic residue [active] 868595003131 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 868595003132 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 868595003133 CoA-binding site [chemical binding]; other site 868595003134 ATP-binding [chemical binding]; other site 868595003135 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 868595003136 Domain of unknown function DUF; Region: DUF204; pfam02659 868595003137 Domain of unknown function DUF; Region: DUF204; pfam02659 868595003138 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 868595003139 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 868595003140 DNA binding site [nucleotide binding] 868595003141 catalytic residue [active] 868595003142 H2TH interface [polypeptide binding]; other site 868595003143 putative catalytic residues [active] 868595003144 turnover-facilitating residue; other site 868595003145 intercalation triad [nucleotide binding]; other site 868595003146 8OG recognition residue [nucleotide binding]; other site 868595003147 putative reading head residues; other site 868595003148 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 868595003149 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 868595003150 DNA polymerase I; Provisional; Region: PRK05755 868595003151 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 868595003152 active site 868595003153 metal binding site 1 [ion binding]; metal-binding site 868595003154 putative 5' ssDNA interaction site; other site 868595003155 metal binding site 3; metal-binding site 868595003156 metal binding site 2 [ion binding]; metal-binding site 868595003157 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 868595003158 putative DNA binding site [nucleotide binding]; other site 868595003159 putative metal binding site [ion binding]; other site 868595003160 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 868595003161 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 868595003162 active site 868595003163 DNA binding site [nucleotide binding] 868595003164 catalytic site [active] 868595003165 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 868595003166 C-terminal peptidase (prc); Region: prc; TIGR00225 868595003167 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 868595003168 protein binding site [polypeptide binding]; other site 868595003169 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 868595003170 Catalytic dyad [active] 868595003171 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595003172 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 868595003173 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 868595003174 Uncharacterized conserved protein [Function unknown]; Region: COG0398 868595003175 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 868595003176 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 868595003177 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 868595003178 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 868595003179 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 868595003180 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595003181 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595003182 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 868595003183 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 868595003184 DNA binding residues [nucleotide binding] 868595003185 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 868595003186 catalytic residues [active] 868595003187 catalytic nucleophile [active] 868595003188 YtxC-like family; Region: YtxC; pfam08812 868595003189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 868595003190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 868595003191 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 868595003192 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 868595003193 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 868595003194 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 868595003195 active site 868595003196 dimer interface [polypeptide binding]; other site 868595003197 motif 1; other site 868595003198 motif 2; other site 868595003199 motif 3; other site 868595003200 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 868595003201 anticodon binding site; other site 868595003202 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 868595003203 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 868595003204 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 868595003205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595003206 dimer interface [polypeptide binding]; other site 868595003207 conserved gate region; other site 868595003208 putative PBP binding loops; other site 868595003209 ABC-ATPase subunit interface; other site 868595003210 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 868595003211 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 868595003212 Walker A/P-loop; other site 868595003213 ATP binding site [chemical binding]; other site 868595003214 Q-loop/lid; other site 868595003215 ABC transporter signature motif; other site 868595003216 Walker B; other site 868595003217 D-loop; other site 868595003218 H-loop/switch region; other site 868595003219 agmatinase; Region: agmatinase; TIGR01230 868595003220 Agmatinase-like family; Region: Agmatinase-like; cd09990 868595003221 active site 868595003222 oligomer interface [polypeptide binding]; other site 868595003223 Mn binding site [ion binding]; other site 868595003224 High-affinity nickel-transport protein; Region: NicO; cl00964 868595003225 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 868595003226 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 868595003227 substrate binding pocket [chemical binding]; other site 868595003228 membrane-bound complex binding site; other site 868595003229 hinge residues; other site 868595003230 Isochorismatase family; Region: Isochorismatase; pfam00857 868595003231 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 868595003232 catalytic triad [active] 868595003233 conserved cis-peptide bond; other site 868595003234 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 868595003235 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 868595003236 agmatinase; Region: agmatinase; TIGR01230 868595003237 Agmatinase-like family; Region: Agmatinase-like; cd09990 868595003238 active site 868595003239 oligomer interface [polypeptide binding]; other site 868595003240 Mn binding site [ion binding]; other site 868595003241 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 868595003242 Transposase domain (DUF772); Region: DUF772; pfam05598 868595003243 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595003244 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 868595003245 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 868595003246 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 868595003247 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 868595003248 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 868595003249 23S rRNA binding site [nucleotide binding]; other site 868595003250 L21 binding site [polypeptide binding]; other site 868595003251 L13 binding site [polypeptide binding]; other site 868595003252 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 868595003253 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 868595003254 Propanediol utilisation protein PduL; Region: PduL; pfam06130 868595003255 Propanediol utilisation protein PduL; Region: PduL; pfam06130 868595003256 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 868595003257 propionate/acetate kinase; Provisional; Region: PRK12379 868595003258 Predicted membrane protein [Function unknown]; Region: COG2119 868595003259 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 868595003260 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 868595003261 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 868595003262 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 868595003263 metal-binding site [ion binding] 868595003264 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 868595003265 Soluble P-type ATPase [General function prediction only]; Region: COG4087 868595003266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595003267 dimerization interface [polypeptide binding]; other site 868595003268 putative DNA binding site [nucleotide binding]; other site 868595003269 putative Zn2+ binding site [ion binding]; other site 868595003270 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 868595003271 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 868595003272 catalytic motif [active] 868595003273 Zn binding site [ion binding]; other site 868595003274 RibD C-terminal domain; Region: RibD_C; cl17279 868595003275 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 868595003276 Lumazine binding domain; Region: Lum_binding; pfam00677 868595003277 Lumazine binding domain; Region: Lum_binding; pfam00677 868595003278 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 868595003279 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 868595003280 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 868595003281 dimerization interface [polypeptide binding]; other site 868595003282 active site 868595003283 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 868595003284 homopentamer interface [polypeptide binding]; other site 868595003285 active site 868595003286 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 868595003287 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 868595003288 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 868595003289 generic binding surface II; other site 868595003290 ssDNA binding site; other site 868595003291 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595003292 ATP binding site [chemical binding]; other site 868595003293 putative Mg++ binding site [ion binding]; other site 868595003294 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 868595003295 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595003296 nucleotide binding region [chemical binding]; other site 868595003297 ATP-binding site [chemical binding]; other site 868595003298 germination protease; Provisional; Region: PRK12362 868595003299 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 868595003300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595003301 S-adenosylmethionine binding site [chemical binding]; other site 868595003302 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 868595003303 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 868595003304 active site 868595003305 (T/H)XGH motif; other site 868595003306 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 868595003307 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 868595003308 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 868595003309 DRTGG domain; Region: DRTGG; pfam07085 868595003310 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 868595003311 CoA binding domain; Region: CoA_binding_2; pfam13380 868595003312 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 868595003313 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 868595003314 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 868595003315 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 868595003316 Nucleoside recognition; Region: Gate; pfam07670 868595003317 Nucleoside recognition; Region: Gate; pfam07670 868595003318 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 868595003319 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 868595003320 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 868595003321 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 868595003322 active site 2 [active] 868595003323 putative phosphate acyltransferase; Provisional; Region: PRK05331 868595003324 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 868595003325 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 868595003326 dimer interface [polypeptide binding]; other site 868595003327 active site 868595003328 CoA binding pocket [chemical binding]; other site 868595003329 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 868595003330 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 868595003331 FMN binding site [chemical binding]; other site 868595003332 substrate binding site [chemical binding]; other site 868595003333 putative catalytic residue [active] 868595003334 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 868595003335 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 868595003336 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 868595003337 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 868595003338 NAD(P) binding site [chemical binding]; other site 868595003339 homotetramer interface [polypeptide binding]; other site 868595003340 homodimer interface [polypeptide binding]; other site 868595003341 active site 868595003342 acyl carrier protein; Provisional; Region: acpP; PRK00982 868595003343 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 868595003344 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 868595003345 dimer interface [polypeptide binding]; other site 868595003346 active site 868595003347 ribonuclease III; Reviewed; Region: rnc; PRK00102 868595003348 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 868595003349 dimerization interface [polypeptide binding]; other site 868595003350 active site 868595003351 metal binding site [ion binding]; metal-binding site 868595003352 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 868595003353 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 868595003354 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 868595003355 Walker A/P-loop; other site 868595003356 ATP binding site [chemical binding]; other site 868595003357 Q-loop/lid; other site 868595003358 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 868595003359 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 868595003360 ABC transporter signature motif; other site 868595003361 Walker B; other site 868595003362 D-loop; other site 868595003363 H-loop/switch region; other site 868595003364 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 868595003365 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 868595003366 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 868595003367 P loop; other site 868595003368 GTP binding site [chemical binding]; other site 868595003369 5'-methylthioadenosine phosphorylase; Validated; Region: PRK08666 868595003370 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 868595003371 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 868595003372 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 868595003373 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 868595003374 homotetramer interface [polypeptide binding]; other site 868595003375 ligand binding site [chemical binding]; other site 868595003376 catalytic site [active] 868595003377 NAD binding site [chemical binding]; other site 868595003378 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 868595003379 intersubunit interface [polypeptide binding]; other site 868595003380 active site 868595003381 Zn2+ binding site [ion binding]; other site 868595003382 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 868595003383 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 868595003384 active site 868595003385 putative substrate binding pocket [chemical binding]; other site 868595003386 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 868595003387 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 868595003388 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 868595003389 putative RNA binding site [nucleotide binding]; other site 868595003390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595003391 S-adenosylmethionine binding site [chemical binding]; other site 868595003392 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 868595003393 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 868595003394 inhibitor-cofactor binding pocket; inhibition site 868595003395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595003396 catalytic residue [active] 868595003397 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595003398 DNA binding residues [nucleotide binding] 868595003399 signal recognition particle protein; Provisional; Region: PRK10867 868595003400 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 868595003401 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 868595003402 P loop; other site 868595003403 GTP binding site [chemical binding]; other site 868595003404 Signal peptide binding domain; Region: SRP_SPB; pfam02978 868595003405 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 868595003406 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 868595003407 hypothetical protein; Provisional; Region: PRK00468 868595003408 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 868595003409 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 868595003410 RimM N-terminal domain; Region: RimM; pfam01782 868595003411 PRC-barrel domain; Region: PRC; pfam05239 868595003412 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 868595003413 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 868595003414 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 868595003415 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 868595003416 Catalytic site [active] 868595003417 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 868595003418 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 868595003419 GTP/Mg2+ binding site [chemical binding]; other site 868595003420 G4 box; other site 868595003421 G5 box; other site 868595003422 G1 box; other site 868595003423 Switch I region; other site 868595003424 G2 box; other site 868595003425 G3 box; other site 868595003426 Switch II region; other site 868595003427 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 868595003428 RNA/DNA hybrid binding site [nucleotide binding]; other site 868595003429 active site 868595003430 NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838 868595003431 NADH dehydrogenase subunit B; Validated; Region: PRK06411 868595003432 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 868595003433 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 868595003434 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 868595003435 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 868595003436 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 868595003437 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 868595003438 4Fe-4S binding domain; Region: Fer4; pfam00037 868595003439 4Fe-4S binding domain; Region: Fer4; cl02805 868595003440 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 868595003441 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 868595003442 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 868595003443 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 868595003444 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 868595003445 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 868595003446 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 868595003447 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 868595003448 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 868595003449 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 868595003450 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 868595003451 hypothetical protein; Reviewed; Region: PRK12497 868595003452 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 868595003453 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 868595003454 Transposase, Mutator family; Region: Transposase_mut; pfam00872 868595003455 MULE transposase domain; Region: MULE; pfam10551 868595003456 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595003457 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 868595003458 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 868595003459 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 868595003460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595003461 Walker A motif; other site 868595003462 ATP binding site [chemical binding]; other site 868595003463 Walker B motif; other site 868595003464 arginine finger; other site 868595003465 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 868595003466 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 868595003467 Helix-turn-helix domain; Region: HTH_36; pfam13730 868595003468 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 868595003469 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 868595003470 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 868595003471 Nucleotide-binding sites [chemical binding]; other site 868595003472 Walker A motif; other site 868595003473 Switch I region of nucleotide binding site; other site 868595003474 Fe4S4 binding sites [ion binding]; other site 868595003475 Switch II region of nucleotide binding site; other site 868595003476 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 868595003477 Nitrogen regulatory protein P-II; Region: P-II; smart00938 868595003478 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 868595003479 Nitrogen regulatory protein P-II; Region: P-II; smart00938 868595003480 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 868595003481 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 868595003482 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 868595003483 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 868595003484 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 868595003485 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 868595003486 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 868595003487 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 868595003488 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595003489 Radical SAM superfamily; Region: Radical_SAM; pfam04055 868595003490 FeS/SAM binding site; other site 868595003491 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; pfam09582 868595003492 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 868595003493 active site 868595003494 catalytic residues [active] 868595003495 metal binding site [ion binding]; metal-binding site 868595003496 Uncharacterized conserved protein [Function unknown]; Region: COG1683 868595003497 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 868595003498 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 868595003499 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 868595003500 P-loop; other site 868595003501 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 868595003502 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 868595003503 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 868595003504 ACS interaction site; other site 868595003505 CODH interaction site; other site 868595003506 cubane metal cluster (B-cluster) [ion binding]; other site 868595003507 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 868595003508 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 868595003509 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 868595003510 ligand binding site [chemical binding]; other site 868595003511 flexible hinge region; other site 868595003512 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 868595003513 putative switch regulator; other site 868595003514 non-specific DNA interactions [nucleotide binding]; other site 868595003515 DNA binding site [nucleotide binding] 868595003516 sequence specific DNA binding site [nucleotide binding]; other site 868595003517 putative cAMP binding site [chemical binding]; other site 868595003518 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 868595003519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595003520 Walker A motif; other site 868595003521 ATP binding site [chemical binding]; other site 868595003522 Walker B motif; other site 868595003523 arginine finger; other site 868595003524 Transposase, Mutator family; Region: Transposase_mut; pfam00872 868595003525 MULE transposase domain; Region: MULE; pfam10551 868595003526 Protein of unknown function (DUF456); Region: DUF456; pfam04306 868595003527 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 868595003528 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 868595003529 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 868595003530 catalytic triad [active] 868595003531 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 868595003532 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 868595003533 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 868595003534 SpoVR like protein; Region: SpoVR; pfam04293 868595003535 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 868595003536 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 868595003537 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 868595003538 putative DNA binding site [nucleotide binding]; other site 868595003539 putative homodimer interface [polypeptide binding]; other site 868595003540 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 868595003541 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 868595003542 active site 868595003543 DNA binding site [nucleotide binding] 868595003544 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 868595003545 DNA binding site [nucleotide binding] 868595003546 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 868595003547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595003548 active site 868595003549 phosphorylation site [posttranslational modification] 868595003550 intermolecular recognition site; other site 868595003551 dimerization interface [polypeptide binding]; other site 868595003552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595003553 Walker A motif; other site 868595003554 ATP binding site [chemical binding]; other site 868595003555 Walker B motif; other site 868595003556 arginine finger; other site 868595003557 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 868595003558 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 868595003559 HAMP domain; Region: HAMP; pfam00672 868595003560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595003561 dimer interface [polypeptide binding]; other site 868595003562 phosphorylation site [posttranslational modification] 868595003563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595003564 ATP binding site [chemical binding]; other site 868595003565 Mg2+ binding site [ion binding]; other site 868595003566 G-X-G motif; other site 868595003567 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 868595003568 HTH domain; Region: HTH_11; cl17392 868595003569 WYL domain; Region: WYL; pfam13280 868595003570 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 868595003571 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 868595003572 Sulfate transporter family; Region: Sulfate_transp; pfam00916 868595003573 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 868595003574 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 868595003575 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 868595003576 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 868595003577 transmembrane helices; other site 868595003578 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 868595003579 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 868595003580 transmembrane helices; other site 868595003581 HTH domain; Region: HTH_11; cl17392 868595003582 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 868595003583 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 868595003584 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 868595003585 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 868595003586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595003587 dimerization interface [polypeptide binding]; other site 868595003588 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 868595003589 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 868595003590 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 868595003591 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 868595003592 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 868595003593 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 868595003594 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 868595003595 ATP binding site [chemical binding]; other site 868595003596 Walker A motif; other site 868595003597 hexamer interface [polypeptide binding]; other site 868595003598 Walker B motif; other site 868595003599 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 868595003600 TadE-like protein; Region: TadE; pfam07811 868595003601 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 868595003602 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 868595003603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595003604 active site 868595003605 phosphorylation site [posttranslational modification] 868595003606 intermolecular recognition site; other site 868595003607 dimerization interface [polypeptide binding]; other site 868595003608 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 868595003609 DNA binding residues [nucleotide binding] 868595003610 dimerization interface [polypeptide binding]; other site 868595003611 Sensor protein DegS; Region: DegS; pfam05384 868595003612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 868595003613 Histidine kinase; Region: HisKA_3; pfam07730 868595003614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595003615 ATP binding site [chemical binding]; other site 868595003616 Mg2+ binding site [ion binding]; other site 868595003617 G-X-G motif; other site 868595003618 histidinol-phosphatase; Provisional; Region: PRK07328 868595003619 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 868595003620 active site 868595003621 dimer interface [polypeptide binding]; other site 868595003622 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 868595003623 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 868595003624 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 868595003625 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 868595003626 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 868595003627 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 868595003628 Transglycosylase; Region: Transgly; pfam00912 868595003629 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 868595003630 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 868595003631 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 868595003632 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 868595003633 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 868595003634 TrkA-N domain; Region: TrkA_N; pfam02254 868595003635 TrkA-C domain; Region: TrkA_C; pfam02080 868595003636 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 868595003637 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 868595003638 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 868595003639 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 868595003640 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 868595003641 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 868595003642 dimer interface [polypeptide binding]; other site 868595003643 motif 1; other site 868595003644 active site 868595003645 motif 2; other site 868595003646 motif 3; other site 868595003647 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 868595003648 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 868595003649 putative tRNA-binding site [nucleotide binding]; other site 868595003650 B3/4 domain; Region: B3_4; pfam03483 868595003651 tRNA synthetase B5 domain; Region: B5; smart00874 868595003652 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 868595003653 dimer interface [polypeptide binding]; other site 868595003654 motif 1; other site 868595003655 motif 3; other site 868595003656 motif 2; other site 868595003657 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 868595003658 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 868595003659 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 868595003660 thiamine phosphate binding site [chemical binding]; other site 868595003661 active site 868595003662 pyrophosphate binding site [ion binding]; other site 868595003663 Cell division protein ZapA; Region: ZapA; cl01146 868595003664 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 868595003665 hypothetical protein; Provisional; Region: PRK08609 868595003666 active site 868595003667 primer binding site [nucleotide binding]; other site 868595003668 NTP binding site [chemical binding]; other site 868595003669 metal binding triad [ion binding]; metal-binding site 868595003670 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 868595003671 active site 868595003672 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 868595003673 active site 868595003674 DNA binding site [nucleotide binding] 868595003675 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 868595003676 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 868595003677 Peptidase family U32; Region: Peptidase_U32; pfam01136 868595003678 Collagenase; Region: DUF3656; pfam12392 868595003679 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 868595003680 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 868595003681 Peptidase family U32; Region: Peptidase_U32; pfam01136 868595003682 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 868595003683 MutS domain III; Region: MutS_III; pfam05192 868595003684 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 868595003685 Walker A/P-loop; other site 868595003686 ATP binding site [chemical binding]; other site 868595003687 Q-loop/lid; other site 868595003688 ABC transporter signature motif; other site 868595003689 Walker B; other site 868595003690 D-loop; other site 868595003691 H-loop/switch region; other site 868595003692 Smr domain; Region: Smr; pfam01713 868595003693 Peptidase family M48; Region: Peptidase_M48; pfam01435 868595003694 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 868595003695 E-class dimer interface [polypeptide binding]; other site 868595003696 P-class dimer interface [polypeptide binding]; other site 868595003697 active site 868595003698 Cu2+ binding site [ion binding]; other site 868595003699 Zn2+ binding site [ion binding]; other site 868595003700 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 868595003701 amino acid carrier protein; Region: agcS; TIGR00835 868595003702 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 868595003703 Family description; Region: VCBS; pfam13517 868595003704 Transglycosylase; Region: Transgly; pfam00912 868595003705 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 868595003706 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 868595003707 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 868595003708 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 868595003709 active site 868595003710 HIGH motif; other site 868595003711 dimer interface [polypeptide binding]; other site 868595003712 KMSKS motif; other site 868595003713 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595003714 RNA binding surface [nucleotide binding]; other site 868595003715 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 868595003716 Flagellin N-methylase; Region: FliB; pfam03692 868595003717 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 868595003718 catalytic loop [active] 868595003719 iron binding site [ion binding]; other site 868595003720 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 868595003721 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595003722 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595003723 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 868595003724 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 868595003725 dimer interface [polypeptide binding]; other site 868595003726 [2Fe-2S] cluster binding site [ion binding]; other site 868595003727 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 868595003728 SLBB domain; Region: SLBB; pfam10531 868595003729 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 868595003730 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 868595003731 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 868595003732 putative dimer interface [polypeptide binding]; other site 868595003733 [2Fe-2S] cluster binding site [ion binding]; other site 868595003734 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 868595003735 Helix-turn-helix domain; Region: HTH_38; pfam13936 868595003736 Integrase core domain; Region: rve; pfam00665 868595003737 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 868595003738 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 868595003739 catalytic loop [active] 868595003740 iron binding site [ion binding]; other site 868595003741 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 868595003742 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595003743 4Fe-4S binding domain; Region: Fer4; pfam00037 868595003744 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595003745 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 868595003746 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 868595003747 dimer interface [polypeptide binding]; other site 868595003748 [2Fe-2S] cluster binding site [ion binding]; other site 868595003749 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 868595003750 SLBB domain; Region: SLBB; pfam10531 868595003751 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 868595003752 4Fe-4S binding domain; Region: Fer4; pfam00037 868595003753 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 868595003754 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 868595003755 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 868595003756 putative dimer interface [polypeptide binding]; other site 868595003757 [2Fe-2S] cluster binding site [ion binding]; other site 868595003758 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595003759 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 868595003760 NAD synthetase; Provisional; Region: PRK13980 868595003761 homodimer interface [polypeptide binding]; other site 868595003762 NAD binding pocket [chemical binding]; other site 868595003763 ATP binding pocket [chemical binding]; other site 868595003764 Mg binding site [ion binding]; other site 868595003765 active-site loop [active] 868595003766 hypothetical protein; Validated; Region: PRK00110 868595003767 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 868595003768 active site 868595003769 putative DNA-binding cleft [nucleotide binding]; other site 868595003770 dimer interface [polypeptide binding]; other site 868595003771 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 868595003772 RuvA N terminal domain; Region: RuvA_N; pfam01330 868595003773 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 868595003774 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 868595003775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595003776 Walker A motif; other site 868595003777 ATP binding site [chemical binding]; other site 868595003778 Walker B motif; other site 868595003779 arginine finger; other site 868595003780 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 868595003781 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595003782 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 868595003783 Ligand Binding Site [chemical binding]; other site 868595003784 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 868595003785 Stage II sporulation protein; Region: SpoIID; pfam08486 868595003786 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 868595003787 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 868595003788 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 868595003789 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 868595003790 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 868595003791 Preprotein translocase subunit; Region: YajC; pfam02699 868595003792 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595003793 Zn2+ binding site [ion binding]; other site 868595003794 Mg2+ binding site [ion binding]; other site 868595003795 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 868595003796 protein-export membrane protein SecD; Region: secD; TIGR01129 868595003797 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 868595003798 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 868595003799 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 868595003800 Protein export membrane protein; Region: SecD_SecF; pfam02355 868595003801 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 868595003802 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 868595003803 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 868595003804 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595003805 RNA binding surface [nucleotide binding]; other site 868595003806 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 868595003807 active site 868595003808 Protein of unknown function (DUF441); Region: DUF441; pfam04284 868595003809 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 868595003810 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 868595003811 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 868595003812 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 868595003813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595003814 Major Facilitator Superfamily; Region: MFS_1; pfam07690 868595003815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595003816 Major Facilitator Superfamily; Region: MFS_1; pfam07690 868595003817 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 868595003818 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 868595003819 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595003820 active site 868595003821 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 868595003822 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 868595003823 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 868595003824 dihydroorotase; Validated; Region: pyrC; PRK09357 868595003825 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 868595003826 active site 868595003827 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 868595003828 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 868595003829 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 868595003830 catalytic site [active] 868595003831 subunit interface [polypeptide binding]; other site 868595003832 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 868595003833 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 868595003834 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 868595003835 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 868595003836 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 868595003837 ATP-grasp domain; Region: ATP-grasp_4; cl17255 868595003838 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 868595003839 IMP binding site; other site 868595003840 dimer interface [polypeptide binding]; other site 868595003841 interdomain contacts; other site 868595003842 partial ornithine binding site; other site 868595003843 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 868595003844 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 868595003845 FAD binding pocket [chemical binding]; other site 868595003846 FAD binding motif [chemical binding]; other site 868595003847 phosphate binding motif [ion binding]; other site 868595003848 beta-alpha-beta structure motif; other site 868595003849 NAD binding pocket [chemical binding]; other site 868595003850 Iron coordination center [ion binding]; other site 868595003851 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 868595003852 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 868595003853 heterodimer interface [polypeptide binding]; other site 868595003854 active site 868595003855 FMN binding site [chemical binding]; other site 868595003856 homodimer interface [polypeptide binding]; other site 868595003857 substrate binding site [chemical binding]; other site 868595003858 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 868595003859 active site 868595003860 dimer interface [polypeptide binding]; other site 868595003861 lipoprotein signal peptidase; Provisional; Region: PRK14787 868595003862 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 868595003863 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595003864 active site 868595003865 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 868595003866 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 868595003867 Domain of unknown function (DUF814); Region: DUF814; pfam05670 868595003868 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 868595003869 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 868595003870 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 868595003871 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 868595003872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 868595003873 motif II; other site 868595003874 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 868595003875 CHASE3 domain; Region: CHASE3; cl05000 868595003876 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 868595003877 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595003878 dimerization interface [polypeptide binding]; other site 868595003879 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595003880 dimer interface [polypeptide binding]; other site 868595003881 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 868595003882 putative CheW interface [polypeptide binding]; other site 868595003883 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 868595003884 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 868595003885 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 868595003886 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 868595003887 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595003888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595003889 homodimer interface [polypeptide binding]; other site 868595003890 catalytic residue [active] 868595003891 aspartate aminotransferase; Provisional; Region: PRK05764 868595003892 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595003893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595003894 homodimer interface [polypeptide binding]; other site 868595003895 catalytic residue [active] 868595003896 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 868595003897 hypothetical protein; Provisional; Region: PRK11820 868595003898 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 868595003899 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 868595003900 hypothetical protein; Provisional; Region: PRK04323 868595003901 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 868595003902 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 868595003903 catalytic site [active] 868595003904 G-X2-G-X-G-K; other site 868595003905 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 868595003906 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 868595003907 Flavoprotein; Region: Flavoprotein; pfam02441 868595003908 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 868595003909 primosome assembly protein PriA; Validated; Region: PRK05580 868595003910 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595003911 ATP binding site [chemical binding]; other site 868595003912 putative Mg++ binding site [ion binding]; other site 868595003913 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595003914 ATP-binding site [chemical binding]; other site 868595003915 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 868595003916 active site 868595003917 catalytic residues [active] 868595003918 metal binding site [ion binding]; metal-binding site 868595003919 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 868595003920 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 868595003921 putative active site [active] 868595003922 substrate binding site [chemical binding]; other site 868595003923 putative cosubstrate binding site; other site 868595003924 catalytic site [active] 868595003925 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 868595003926 substrate binding site [chemical binding]; other site 868595003927 Protein of unknown function DUF116; Region: DUF116; pfam01976 868595003928 16S rRNA methyltransferase B; Provisional; Region: PRK14902 868595003929 NusB family; Region: NusB; pfam01029 868595003930 putative RNA binding site [nucleotide binding]; other site 868595003931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595003932 S-adenosylmethionine binding site [chemical binding]; other site 868595003933 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 868595003934 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595003935 FeS/SAM binding site; other site 868595003936 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 868595003937 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 868595003938 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 868595003939 phosphopeptide binding site; other site 868595003940 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 868595003941 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 868595003942 phosphopeptide binding site; other site 868595003943 Protein phosphatase 2C; Region: PP2C; pfam00481 868595003944 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 868595003945 active site 868595003946 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 868595003947 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 868595003948 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 868595003949 Catalytic domain of Protein Kinases; Region: PKc; cd00180 868595003950 active site 868595003951 ATP binding site [chemical binding]; other site 868595003952 substrate binding site [chemical binding]; other site 868595003953 activation loop (A-loop); other site 868595003954 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 868595003955 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 868595003956 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 868595003957 GTPase RsgA; Reviewed; Region: PRK00098 868595003958 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 868595003959 RNA binding site [nucleotide binding]; other site 868595003960 homodimer interface [polypeptide binding]; other site 868595003961 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 868595003962 GTPase/Zn-binding domain interface [polypeptide binding]; other site 868595003963 GTP/Mg2+ binding site [chemical binding]; other site 868595003964 G4 box; other site 868595003965 G5 box; other site 868595003966 G1 box; other site 868595003967 Switch I region; other site 868595003968 G2 box; other site 868595003969 G3 box; other site 868595003970 Switch II region; other site 868595003971 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 868595003972 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 868595003973 substrate binding site [chemical binding]; other site 868595003974 hexamer interface [polypeptide binding]; other site 868595003975 metal binding site [ion binding]; metal-binding site 868595003976 ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Region: COG2401 868595003977 adenylate kinase; Reviewed; Region: adk; PRK00279 868595003978 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 868595003979 AMP-binding site [chemical binding]; other site 868595003980 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 868595003981 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 868595003982 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 868595003983 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 868595003984 putative ligand binding site [chemical binding]; other site 868595003985 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 868595003986 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 868595003987 TM-ABC transporter signature motif; other site 868595003988 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 868595003989 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 868595003990 TM-ABC transporter signature motif; other site 868595003991 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 868595003992 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 868595003993 Walker A/P-loop; other site 868595003994 ATP binding site [chemical binding]; other site 868595003995 Q-loop/lid; other site 868595003996 ABC transporter signature motif; other site 868595003997 Walker B; other site 868595003998 D-loop; other site 868595003999 H-loop/switch region; other site 868595004000 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 868595004001 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 868595004002 Walker A/P-loop; other site 868595004003 ATP binding site [chemical binding]; other site 868595004004 Q-loop/lid; other site 868595004005 ABC transporter signature motif; other site 868595004006 Walker B; other site 868595004007 D-loop; other site 868595004008 H-loop/switch region; other site 868595004009 PAS domain; Region: PAS_9; pfam13426 868595004010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595004011 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 868595004012 Walker A motif; other site 868595004013 ATP binding site [chemical binding]; other site 868595004014 Walker B motif; other site 868595004015 arginine finger; other site 868595004016 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 868595004017 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 868595004018 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 868595004019 putative ligand binding site [chemical binding]; other site 868595004020 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 868595004021 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 868595004022 TM-ABC transporter signature motif; other site 868595004023 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 868595004024 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 868595004025 TM-ABC transporter signature motif; other site 868595004026 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 868595004027 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 868595004028 Walker A/P-loop; other site 868595004029 ATP binding site [chemical binding]; other site 868595004030 Q-loop/lid; other site 868595004031 ABC transporter signature motif; other site 868595004032 Walker B; other site 868595004033 D-loop; other site 868595004034 H-loop/switch region; other site 868595004035 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 868595004036 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 868595004037 Walker A/P-loop; other site 868595004038 ATP binding site [chemical binding]; other site 868595004039 Q-loop/lid; other site 868595004040 ABC transporter signature motif; other site 868595004041 Walker B; other site 868595004042 D-loop; other site 868595004043 H-loop/switch region; other site 868595004044 FOG: CBS domain [General function prediction only]; Region: COG0517 868595004045 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 868595004046 PAS domain S-box; Region: sensory_box; TIGR00229 868595004047 PAS domain; Region: PAS; smart00091 868595004048 putative active site [active] 868595004049 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 868595004050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595004051 Walker A motif; other site 868595004052 ATP binding site [chemical binding]; other site 868595004053 Walker B motif; other site 868595004054 arginine finger; other site 868595004055 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 868595004056 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 868595004057 catalytic loop [active] 868595004058 iron binding site [ion binding]; other site 868595004059 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 868595004060 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 868595004061 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 868595004062 4Fe-4S binding domain; Region: Fer4; pfam00037 868595004063 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 868595004064 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 868595004065 hydroxyglutarate oxidase; Provisional; Region: PRK11728 868595004066 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595004067 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 868595004068 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595004069 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 868595004070 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 868595004071 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 868595004072 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 868595004073 Ubiquitin-like proteins; Region: UBQ; cl00155 868595004074 charged pocket; other site 868595004075 hydrophobic patch; other site 868595004076 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 868595004077 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595004078 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 868595004079 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 868595004080 dimer interface [polypeptide binding]; other site 868595004081 PYR/PP interface [polypeptide binding]; other site 868595004082 TPP binding site [chemical binding]; other site 868595004083 substrate binding site [chemical binding]; other site 868595004084 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 868595004085 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 868595004086 TPP-binding site [chemical binding]; other site 868595004087 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 868595004088 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 868595004089 Spore germination protein; Region: Spore_permease; cl17796 868595004090 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 868595004091 RQC domain; Region: RQC; cl09632 868595004092 HEAT repeats; Region: HEAT_2; pfam13646 868595004093 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 868595004094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 868595004095 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 868595004096 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 868595004097 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 868595004098 CoA-ligase; Region: Ligase_CoA; pfam00549 868595004099 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 868595004100 CoA binding domain; Region: CoA_binding; pfam02629 868595004101 CoA-ligase; Region: Ligase_CoA; pfam00549 868595004102 metal-dependent hydrolase; Provisional; Region: PRK00685 868595004103 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 868595004104 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 868595004105 active site 868595004106 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 868595004107 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 868595004108 active site 868595004109 catalytic site [active] 868595004110 substrate binding site [chemical binding]; other site 868595004111 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 868595004112 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595004113 nucleotide binding region [chemical binding]; other site 868595004114 ATP-binding site [chemical binding]; other site 868595004115 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 868595004116 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 868595004117 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 868595004118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595004119 dimer interface [polypeptide binding]; other site 868595004120 phosphorylation site [posttranslational modification] 868595004121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595004122 ATP binding site [chemical binding]; other site 868595004123 Mg2+ binding site [ion binding]; other site 868595004124 G-X-G motif; other site 868595004125 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 868595004126 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 868595004127 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004128 FeS/SAM binding site; other site 868595004129 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 868595004130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 868595004131 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 868595004132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 868595004133 Coenzyme A binding pocket [chemical binding]; other site 868595004134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 868595004135 binding surface 868595004136 TPR motif; other site 868595004137 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595004138 binding surface 868595004139 Tetratricopeptide repeat; Region: TPR_12; pfam13424 868595004140 TPR motif; other site 868595004141 TPR repeat; Region: TPR_11; pfam13414 868595004142 TPR repeat; Region: TPR_11; pfam13414 868595004143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595004144 binding surface 868595004145 TPR motif; other site 868595004146 TPR repeat; Region: TPR_11; pfam13414 868595004147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595004148 binding surface 868595004149 TPR motif; other site 868595004150 Tetratricopeptide repeat; Region: TPR_16; pfam13432 868595004151 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 868595004152 active site 868595004153 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 868595004154 Ligand Binding Site [chemical binding]; other site 868595004155 Domain of unknown function (DUF366); Region: DUF366; pfam04017 868595004156 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 868595004157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004158 FeS/SAM binding site; other site 868595004159 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 868595004160 homodecamer interface [polypeptide binding]; other site 868595004161 GTP cyclohydrolase I; Provisional; Region: PLN03044 868595004162 active site 868595004163 putative catalytic site residues [active] 868595004164 zinc binding site [ion binding]; other site 868595004165 GTP-CH-I/GFRP interaction surface; other site 868595004166 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 868595004167 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 868595004168 oxidase reductase; Provisional; Region: PTZ00273 868595004169 stage V sporulation protein B; Region: spore_V_B; TIGR02900 868595004170 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 868595004171 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 868595004172 elongation factor G; Reviewed; Region: PRK12740 868595004173 G1 box; other site 868595004174 putative GEF interaction site [polypeptide binding]; other site 868595004175 GTP/Mg2+ binding site [chemical binding]; other site 868595004176 Switch I region; other site 868595004177 G2 box; other site 868595004178 G3 box; other site 868595004179 Switch II region; other site 868595004180 G4 box; other site 868595004181 G5 box; other site 868595004182 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 868595004183 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 868595004184 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 868595004185 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 868595004186 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 868595004187 4Fe-4S binding domain; Region: Fer4; pfam00037 868595004188 4Fe-4S binding domain; Region: Fer4; pfam00037 868595004189 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595004190 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 868595004191 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 868595004192 ATP-grasp domain; Region: ATP-grasp_4; cl17255 868595004193 Uncharacterized conserved protein [Function unknown]; Region: COG1615 868595004194 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 868595004195 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 868595004196 phosphofructokinase; Region: PFK_mixed; TIGR02483 868595004197 active site 868595004198 ADP/pyrophosphate binding site [chemical binding]; other site 868595004199 dimerization interface [polypeptide binding]; other site 868595004200 allosteric effector site; other site 868595004201 fructose-1,6-bisphosphate binding site; other site 868595004202 Late competence development protein ComFB; Region: ComFB; pfam10719 868595004203 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 868595004204 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 868595004205 putative ADP-binding pocket [chemical binding]; other site 868595004206 Yqey-like protein; Region: YqeY; pfam09424 868595004207 Protein of unknown function DUF89; Region: DUF89; cl15397 868595004208 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 868595004209 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 868595004210 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 868595004211 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 868595004212 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 868595004213 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 868595004214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595004215 Walker A motif; other site 868595004216 ATP binding site [chemical binding]; other site 868595004217 Walker B motif; other site 868595004218 arginine finger; other site 868595004219 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 868595004220 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 868595004221 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 868595004222 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 868595004223 catalytic residue [active] 868595004224 Predicted integral membrane protein [Function unknown]; Region: COG5652 868595004225 FOG: CBS domain [General function prediction only]; Region: COG0517 868595004226 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 868595004227 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 868595004228 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 868595004229 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 868595004230 Carbon starvation protein CstA; Region: CstA; pfam02554 868595004231 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 868595004232 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 868595004233 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 868595004234 Potassium binding sites [ion binding]; other site 868595004235 Cesium cation binding sites [ion binding]; other site 868595004236 Radical SAM superfamily; Region: Radical_SAM; pfam04055 868595004237 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004238 FeS/SAM binding site; other site 868595004239 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 868595004240 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595004241 Zn2+ binding site [ion binding]; other site 868595004242 Mg2+ binding site [ion binding]; other site 868595004243 Protein of unknown function (DUF342); Region: DUF342; pfam03961 868595004244 Transposase, Mutator family; Region: Transposase_mut; pfam00872 868595004245 MULE transposase domain; Region: MULE; pfam10551 868595004246 malate dehydrogenase; Reviewed; Region: PRK06223 868595004247 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 868595004248 NAD(P) binding site [chemical binding]; other site 868595004249 dimer interface [polypeptide binding]; other site 868595004250 tetramer (dimer of dimers) interface [polypeptide binding]; other site 868595004251 substrate binding site [chemical binding]; other site 868595004252 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 868595004253 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 868595004254 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 868595004255 L-aspartate oxidase; Provisional; Region: PRK06175 868595004256 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 868595004257 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 868595004258 Iron-sulfur protein interface; other site 868595004259 proximal heme binding site [chemical binding]; other site 868595004260 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 868595004261 Fumarase C-terminus; Region: Fumerase_C; cl00795 868595004262 fumarate hydratase; Provisional; Region: PRK06246 868595004263 PAS domain; Region: PAS_8; pfam13188 868595004264 PAS fold; Region: PAS_4; pfam08448 868595004265 putative active site [active] 868595004266 heme pocket [chemical binding]; other site 868595004267 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 868595004268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595004269 ATP binding site [chemical binding]; other site 868595004270 Walker B motif; other site 868595004271 arginine finger; other site 868595004272 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 868595004273 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 868595004274 Transposase; Region: DEDD_Tnp_IS110; pfam01548 868595004275 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 868595004276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 868595004277 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 868595004278 LexA repressor; Validated; Region: PRK00215 868595004279 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 868595004280 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 868595004281 Catalytic site [active] 868595004282 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 868595004283 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 868595004284 DNA binding residues [nucleotide binding] 868595004285 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 868595004286 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 868595004287 DctM-like transporters; Region: DctM; pfam06808 868595004288 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 868595004289 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 868595004290 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 868595004291 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 868595004292 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 868595004293 Aluminium resistance protein; Region: Alum_res; pfam06838 868595004294 stage V sporulation protein K; Region: spore_V_K; TIGR02881 868595004295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595004296 Walker A motif; other site 868595004297 ATP binding site [chemical binding]; other site 868595004298 Walker B motif; other site 868595004299 arginine finger; other site 868595004300 bacterial Hfq-like; Region: Hfq; cd01716 868595004301 hexamer interface [polypeptide binding]; other site 868595004302 Sm1 motif; other site 868595004303 RNA binding site [nucleotide binding]; other site 868595004304 Sm2 motif; other site 868595004305 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 868595004306 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 868595004307 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 868595004308 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 868595004309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595004310 ATP binding site [chemical binding]; other site 868595004311 Mg2+ binding site [ion binding]; other site 868595004312 G-X-G motif; other site 868595004313 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 868595004314 ATP binding site [chemical binding]; other site 868595004315 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 868595004316 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 868595004317 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 868595004318 active site 868595004319 Zn binding site [ion binding]; other site 868595004320 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 868595004321 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 868595004322 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 868595004323 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 868595004324 MutS domain I; Region: MutS_I; pfam01624 868595004325 MutS domain II; Region: MutS_II; pfam05188 868595004326 MutS domain III; Region: MutS_III; pfam05192 868595004327 MutS domain V; Region: MutS_V; pfam00488 868595004328 Walker A/P-loop; other site 868595004329 ATP binding site [chemical binding]; other site 868595004330 Q-loop/lid; other site 868595004331 ABC transporter signature motif; other site 868595004332 Walker B; other site 868595004333 D-loop; other site 868595004334 H-loop/switch region; other site 868595004335 Protein of unknown function (DUF964); Region: DUF964; pfam06133 868595004336 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 868595004337 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 868595004338 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004339 FeS/SAM binding site; other site 868595004340 TRAM domain; Region: TRAM; cl01282 868595004341 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 868595004342 PAS domain; Region: PAS; smart00091 868595004343 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 868595004344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595004345 active site 868595004346 phosphorylation site [posttranslational modification] 868595004347 intermolecular recognition site; other site 868595004348 dimerization interface [polypeptide binding]; other site 868595004349 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 868595004350 DNA binding residues [nucleotide binding] 868595004351 dimerization interface [polypeptide binding]; other site 868595004352 PAS domain; Region: PAS; smart00091 868595004353 PAS fold; Region: PAS; pfam00989 868595004354 putative active site [active] 868595004355 heme pocket [chemical binding]; other site 868595004356 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 868595004357 Histidine kinase; Region: HisKA_3; pfam07730 868595004358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595004359 ATP binding site [chemical binding]; other site 868595004360 Mg2+ binding site [ion binding]; other site 868595004361 G-X-G motif; other site 868595004362 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 868595004363 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 868595004364 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 868595004365 active site 868595004366 acyl-activating enzyme (AAE) consensus motif; other site 868595004367 putative CoA binding site [chemical binding]; other site 868595004368 AMP binding site [chemical binding]; other site 868595004369 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 868595004370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595004371 NAD(P) binding site [chemical binding]; other site 868595004372 active site 868595004373 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 868595004374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595004375 NAD(P) binding site [chemical binding]; other site 868595004376 active site 868595004377 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 868595004378 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 868595004379 substrate binding site; other site 868595004380 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 868595004381 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 868595004382 Ligand binding site; other site 868595004383 Putative Catalytic site; other site 868595004384 DXD motif; other site 868595004385 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 868595004386 septum formation inhibitor; Reviewed; Region: minC; PRK00513 868595004387 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 868595004388 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 868595004389 ADP-ribose binding site [chemical binding]; other site 868595004390 dimer interface [polypeptide binding]; other site 868595004391 active site 868595004392 nudix motif; other site 868595004393 metal binding site [ion binding]; metal-binding site 868595004394 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 868595004395 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595004396 dimerization interface [polypeptide binding]; other site 868595004397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595004398 dimer interface [polypeptide binding]; other site 868595004399 phosphorylation site [posttranslational modification] 868595004400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595004401 ATP binding site [chemical binding]; other site 868595004402 Mg2+ binding site [ion binding]; other site 868595004403 G-X-G motif; other site 868595004404 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595004405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595004406 active site 868595004407 phosphorylation site [posttranslational modification] 868595004408 intermolecular recognition site; other site 868595004409 dimerization interface [polypeptide binding]; other site 868595004410 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595004411 DNA binding site [nucleotide binding] 868595004412 Transposase, Mutator family; Region: Transposase_mut; pfam00872 868595004413 MULE transposase domain; Region: MULE; pfam10551 868595004414 AAA domain; Region: AAA_31; pfam13614 868595004415 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 868595004416 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 868595004417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 868595004418 Coenzyme A binding pocket [chemical binding]; other site 868595004419 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 868595004420 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 868595004421 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 868595004422 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 868595004423 active site 868595004424 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 868595004425 catalytic core [active] 868595004426 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 868595004427 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 868595004428 homotrimer interface [polypeptide binding]; other site 868595004429 Walker A motif; other site 868595004430 GTP binding site [chemical binding]; other site 868595004431 Walker B motif; other site 868595004432 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595004433 Zn2+ binding site [ion binding]; other site 868595004434 Mg2+ binding site [ion binding]; other site 868595004435 Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253 868595004436 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 868595004437 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595004438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595004439 homodimer interface [polypeptide binding]; other site 868595004440 catalytic residue [active] 868595004441 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 868595004442 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 868595004443 active site 868595004444 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 868595004445 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 868595004446 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 868595004447 active site 868595004448 dimer interface [polypeptide binding]; other site 868595004449 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 868595004450 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 868595004451 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 868595004452 putative active site [active] 868595004453 metal binding site [ion binding]; metal-binding site 868595004454 homodimer binding site [polypeptide binding]; other site 868595004455 phosphodiesterase; Provisional; Region: PRK12704 868595004456 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595004457 Zn2+ binding site [ion binding]; other site 868595004458 Mg2+ binding site [ion binding]; other site 868595004459 recombinase A; Provisional; Region: recA; PRK09354 868595004460 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 868595004461 hexamer interface [polypeptide binding]; other site 868595004462 Walker A motif; other site 868595004463 ATP binding site [chemical binding]; other site 868595004464 Walker B motif; other site 868595004465 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 868595004466 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 868595004467 ATP binding site [chemical binding]; other site 868595004468 Mg++ binding site [ion binding]; other site 868595004469 motif III; other site 868595004470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595004471 nucleotide binding region [chemical binding]; other site 868595004472 ATP-binding site [chemical binding]; other site 868595004473 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 868595004474 RNA binding site [nucleotide binding]; other site 868595004475 competence damage-inducible protein A; Provisional; Region: PRK00549 868595004476 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 868595004477 putative MPT binding site; other site 868595004478 Competence-damaged protein; Region: CinA; pfam02464 868595004479 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 868595004480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595004481 Walker A motif; other site 868595004482 ATP binding site [chemical binding]; other site 868595004483 Walker B motif; other site 868595004484 arginine finger; other site 868595004485 Peptidase family M41; Region: Peptidase_M41; pfam01434 868595004486 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 868595004487 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 868595004488 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 868595004489 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004490 FeS/SAM binding site; other site 868595004491 TRAM domain; Region: TRAM; cl01282 868595004492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 868595004493 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 868595004494 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 868595004495 DNA protecting protein DprA; Region: dprA; TIGR00732 868595004496 anaerobic ribonucleoside-triphosphate reductase; Region: RNR_anaer_Bdell; TIGR02827 868595004497 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 868595004498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 868595004499 non-specific DNA binding site [nucleotide binding]; other site 868595004500 salt bridge; other site 868595004501 sequence-specific DNA binding site [nucleotide binding]; other site 868595004502 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 868595004503 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 868595004504 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 868595004505 active site residue [active] 868595004506 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 868595004507 active site 868595004508 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 868595004509 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 868595004510 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 868595004511 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 868595004512 Coat F domain; Region: Coat_F; pfam07875 868595004513 YlzJ-like protein; Region: YlzJ; pfam14035 868595004514 Clp protease; Region: CLP_protease; pfam00574 868595004515 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 868595004516 active site 868595004517 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 868595004518 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 868595004519 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 868595004520 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 868595004521 dihydrodipicolinate synthase; Region: dapA; TIGR00674 868595004522 dimer interface [polypeptide binding]; other site 868595004523 active site 868595004524 catalytic residue [active] 868595004525 aspartate kinase I; Reviewed; Region: PRK08210 868595004526 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 868595004527 putative catalytic residues [active] 868595004528 putative nucleotide binding site [chemical binding]; other site 868595004529 putative aspartate binding site [chemical binding]; other site 868595004530 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 868595004531 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 868595004532 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 868595004533 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 868595004534 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 868595004535 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 868595004536 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 868595004537 NAD binding site [chemical binding]; other site 868595004538 dihydrodipicolinate reductase; Provisional; Region: PRK00048 868595004539 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 868595004540 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 868595004541 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 868595004542 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 868595004543 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 868595004544 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 868595004545 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 868595004546 NodB motif; other site 868595004547 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 868595004548 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 868595004549 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 868595004550 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 868595004551 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 868595004552 RNase E interface [polypeptide binding]; other site 868595004553 trimer interface [polypeptide binding]; other site 868595004554 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 868595004555 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 868595004556 RNase E interface [polypeptide binding]; other site 868595004557 trimer interface [polypeptide binding]; other site 868595004558 active site 868595004559 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 868595004560 putative nucleic acid binding region [nucleotide binding]; other site 868595004561 G-X-X-G motif; other site 868595004562 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 868595004563 RNA binding site [nucleotide binding]; other site 868595004564 domain interface; other site 868595004565 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 868595004566 16S/18S rRNA binding site [nucleotide binding]; other site 868595004567 S13e-L30e interaction site [polypeptide binding]; other site 868595004568 25S rRNA binding site [nucleotide binding]; other site 868595004569 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 868595004570 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 868595004571 active site 868595004572 Riboflavin kinase; Region: Flavokinase; smart00904 868595004573 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 868595004574 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 868595004575 RNA binding site [nucleotide binding]; other site 868595004576 active site 868595004577 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 868595004578 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 868595004579 DHH family; Region: DHH; pfam01368 868595004580 DHHA1 domain; Region: DHHA1; pfam02272 868595004581 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 868595004582 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 868595004583 translation initiation factor IF-2; Region: IF-2; TIGR00487 868595004584 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 868595004585 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 868595004586 G1 box; other site 868595004587 putative GEF interaction site [polypeptide binding]; other site 868595004588 GTP/Mg2+ binding site [chemical binding]; other site 868595004589 Switch I region; other site 868595004590 G2 box; other site 868595004591 G3 box; other site 868595004592 Switch II region; other site 868595004593 G4 box; other site 868595004594 G5 box; other site 868595004595 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 868595004596 Translation-initiation factor 2; Region: IF-2; pfam11987 868595004597 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 868595004598 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 868595004599 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 868595004600 putative RNA binding cleft [nucleotide binding]; other site 868595004601 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 868595004602 NusA N-terminal domain; Region: NusA_N; pfam08529 868595004603 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 868595004604 RNA binding site [nucleotide binding]; other site 868595004605 homodimer interface [polypeptide binding]; other site 868595004606 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 868595004607 G-X-X-G motif; other site 868595004608 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 868595004609 G-X-X-G motif; other site 868595004610 ribosome maturation protein RimP; Reviewed; Region: PRK00092 868595004611 Sm and related proteins; Region: Sm_like; cl00259 868595004612 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 868595004613 putative oligomer interface [polypeptide binding]; other site 868595004614 putative RNA binding site [nucleotide binding]; other site 868595004615 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 868595004616 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 868595004617 NodB motif; other site 868595004618 active site 868595004619 catalytic site [active] 868595004620 Cd binding site [ion binding]; other site 868595004621 Bacterial Ig-like domain; Region: Big_5; pfam13205 868595004622 DNA polymerase III PolC; Validated; Region: polC; PRK00448 868595004623 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 868595004624 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 868595004625 generic binding surface II; other site 868595004626 generic binding surface I; other site 868595004627 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 868595004628 active site 868595004629 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 868595004630 active site 868595004631 catalytic site [active] 868595004632 substrate binding site [chemical binding]; other site 868595004633 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 868595004634 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 868595004635 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 868595004636 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 868595004637 prolyl-tRNA synthetase; Provisional; Region: PRK09194 868595004638 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 868595004639 dimer interface [polypeptide binding]; other site 868595004640 motif 1; other site 868595004641 active site 868595004642 motif 2; other site 868595004643 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 868595004644 putative deacylase active site [active] 868595004645 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 868595004646 active site 868595004647 motif 3; other site 868595004648 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 868595004649 anticodon binding site; other site 868595004650 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 868595004651 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 868595004652 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 868595004653 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 868595004654 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 868595004655 active site 868595004656 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 868595004657 protein binding site [polypeptide binding]; other site 868595004658 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 868595004659 putative substrate binding region [chemical binding]; other site 868595004660 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 868595004661 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 868595004662 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 868595004663 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 868595004664 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 868595004665 Domain of unknown function DUF20; Region: UPF0118; pfam01594 868595004666 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 868595004667 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 868595004668 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 868595004669 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 868595004670 catalytic residue [active] 868595004671 putative FPP diphosphate binding site; other site 868595004672 putative FPP binding hydrophobic cleft; other site 868595004673 dimer interface [polypeptide binding]; other site 868595004674 putative IPP diphosphate binding site; other site 868595004675 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595004676 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 868595004677 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 868595004678 ribosome recycling factor; Reviewed; Region: frr; PRK00083 868595004679 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 868595004680 hinge region; other site 868595004681 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 868595004682 putative nucleotide binding site [chemical binding]; other site 868595004683 uridine monophosphate binding site [chemical binding]; other site 868595004684 homohexameric interface [polypeptide binding]; other site 868595004685 elongation factor Ts; Reviewed; Region: tsf; PRK12332 868595004686 UBA/TS-N domain; Region: UBA; pfam00627 868595004687 Elongation factor TS; Region: EF_TS; pfam00889 868595004688 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 868595004689 rRNA interaction site [nucleotide binding]; other site 868595004690 S8 interaction site; other site 868595004691 putative laminin-1 binding site; other site 868595004692 transcriptional repressor CodY; Validated; Region: PRK04158 868595004693 CodY GAF-like domain; Region: CodY; pfam06018 868595004694 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 868595004695 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 868595004696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595004697 Walker A motif; other site 868595004698 ATP binding site [chemical binding]; other site 868595004699 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 868595004700 Walker B motif; other site 868595004701 arginine finger; other site 868595004702 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 868595004703 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 868595004704 active site 868595004705 HslU subunit interaction site [polypeptide binding]; other site 868595004706 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 868595004707 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 868595004708 active site 868595004709 Int/Topo IB signature motif; other site 868595004710 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 868595004711 Glucose inhibited division protein A; Region: GIDA; pfam01134 868595004712 DNA topoisomerase I; Validated; Region: PRK05582 868595004713 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 868595004714 active site 868595004715 interdomain interaction site; other site 868595004716 putative metal-binding site [ion binding]; other site 868595004717 nucleotide binding site [chemical binding]; other site 868595004718 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 868595004719 domain I; other site 868595004720 DNA binding groove [nucleotide binding] 868595004721 phosphate binding site [ion binding]; other site 868595004722 domain II; other site 868595004723 domain III; other site 868595004724 nucleotide binding site [chemical binding]; other site 868595004725 catalytic site [active] 868595004726 domain IV; other site 868595004727 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 868595004728 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 868595004729 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 868595004730 DNA protecting protein DprA; Region: dprA; TIGR00732 868595004731 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 868595004732 nucleotide binding site [chemical binding]; other site 868595004733 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 868595004734 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 868595004735 homodimer interface [polypeptide binding]; other site 868595004736 substrate-cofactor binding pocket; other site 868595004737 catalytic residue [active] 868595004738 PAS fold; Region: PAS_4; pfam08448 868595004739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595004740 putative active site [active] 868595004741 heme pocket [chemical binding]; other site 868595004742 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 868595004743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595004744 putative active site [active] 868595004745 heme pocket [chemical binding]; other site 868595004746 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 868595004747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595004748 putative active site [active] 868595004749 heme pocket [chemical binding]; other site 868595004750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595004751 dimer interface [polypeptide binding]; other site 868595004752 phosphorylation site [posttranslational modification] 868595004753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595004754 ATP binding site [chemical binding]; other site 868595004755 Mg2+ binding site [ion binding]; other site 868595004756 G-X-G motif; other site 868595004757 Response regulator receiver domain; Region: Response_reg; pfam00072 868595004758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595004759 active site 868595004760 phosphorylation site [posttranslational modification] 868595004761 intermolecular recognition site; other site 868595004762 dimerization interface [polypeptide binding]; other site 868595004763 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 868595004764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595004765 active site 868595004766 phosphorylation site [posttranslational modification] 868595004767 intermolecular recognition site; other site 868595004768 dimerization interface [polypeptide binding]; other site 868595004769 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 868595004770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595004771 active site 868595004772 phosphorylation site [posttranslational modification] 868595004773 intermolecular recognition site; other site 868595004774 dimerization interface [polypeptide binding]; other site 868595004775 Hpt domain; Region: Hpt; pfam01627 868595004776 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 868595004777 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004778 FeS/SAM binding site; other site 868595004779 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 868595004780 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 868595004781 DNA-binding site [nucleotide binding]; DNA binding site 868595004782 TrkA-C domain; Region: TrkA_C; pfam02080 868595004783 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 868595004784 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004785 FeS/SAM binding site; other site 868595004786 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 868595004787 biotin synthase; Provisional; Region: PRK07094 868595004788 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004789 FeS/SAM binding site; other site 868595004790 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 868595004791 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 868595004792 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 868595004793 putative CheA interaction surface; other site 868595004794 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 868595004795 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 868595004796 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 868595004797 inhibitor-cofactor binding pocket; inhibition site 868595004798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595004799 catalytic residue [active] 868595004800 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 868595004801 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 868595004802 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 868595004803 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 868595004804 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 868595004805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004806 FeS/SAM binding site; other site 868595004807 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 868595004808 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 868595004809 dimer interface [polypeptide binding]; other site 868595004810 active site 868595004811 Schiff base residues; other site 868595004812 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 868595004813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004814 FeS/SAM binding site; other site 868595004815 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 868595004816 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 868595004817 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 868595004818 active site 868595004819 SAM binding site [chemical binding]; other site 868595004820 homodimer interface [polypeptide binding]; other site 868595004821 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 868595004822 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 868595004823 active site 868595004824 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 868595004825 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 868595004826 domain interfaces; other site 868595004827 active site 868595004828 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 868595004829 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 868595004830 tRNA; other site 868595004831 putative tRNA binding site [nucleotide binding]; other site 868595004832 putative NADP binding site [chemical binding]; other site 868595004833 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 868595004834 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 868595004835 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 868595004836 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 868595004837 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 868595004838 substrate binding pocket [chemical binding]; other site 868595004839 chain length determination region; other site 868595004840 substrate-Mg2+ binding site; other site 868595004841 catalytic residues [active] 868595004842 aspartate-rich region 1; other site 868595004843 active site lid residues [active] 868595004844 aspartate-rich region 2; other site 868595004845 Flagellin N-methylase; Region: FliB; cl00497 868595004846 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 868595004847 Ligand Binding Site [chemical binding]; other site 868595004848 S-layer homology domain; Region: SLH; pfam00395 868595004849 PrcB C-terminal; Region: PrcB_C; pfam14343 868595004850 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 868595004851 DNA-binding site [nucleotide binding]; DNA binding site 868595004852 RNA-binding motif; other site 868595004853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 868595004854 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 868595004855 Walker A/P-loop; other site 868595004856 ATP binding site [chemical binding]; other site 868595004857 Q-loop/lid; other site 868595004858 ABC transporter signature motif; other site 868595004859 Walker B; other site 868595004860 D-loop; other site 868595004861 H-loop/switch region; other site 868595004862 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 868595004863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595004864 dimer interface [polypeptide binding]; other site 868595004865 conserved gate region; other site 868595004866 putative PBP binding loops; other site 868595004867 ABC-ATPase subunit interface; other site 868595004868 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 868595004869 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 868595004870 Helix-turn-helix domain; Region: HTH_17; pfam12728 868595004871 PBP superfamily domain; Region: PBP_like; pfam12727 868595004872 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 868595004873 catalytic core [active] 868595004874 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 868595004875 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 868595004876 Ligand binding site; other site 868595004877 metal-binding site 868595004878 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595004879 Zn2+ binding site [ion binding]; other site 868595004880 Mg2+ binding site [ion binding]; other site 868595004881 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 868595004882 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 868595004883 XdhC Rossmann domain; Region: XdhC_C; pfam13478 868595004884 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 868595004885 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 868595004886 acyl-activating enzyme (AAE) consensus motif; other site 868595004887 AMP binding site [chemical binding]; other site 868595004888 active site 868595004889 CoA binding site [chemical binding]; other site 868595004890 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004891 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 868595004892 FeS/SAM binding site; other site 868595004893 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 868595004894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595004895 S-adenosylmethionine binding site [chemical binding]; other site 868595004896 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 868595004897 Cysteine-rich domain; Region: CCG; pfam02754 868595004898 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 868595004899 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 868595004900 catalytic loop [active] 868595004901 iron binding site [ion binding]; other site 868595004902 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 868595004903 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 868595004904 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 868595004905 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 868595004906 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 868595004907 putative MPT binding site; other site 868595004908 Nucleoside recognition; Region: Gate; pfam07670 868595004909 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 868595004910 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 868595004911 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 868595004912 G1 box; other site 868595004913 putative GEF interaction site [polypeptide binding]; other site 868595004914 GTP/Mg2+ binding site [chemical binding]; other site 868595004915 Switch I region; other site 868595004916 G2 box; other site 868595004917 G3 box; other site 868595004918 Switch II region; other site 868595004919 G4 box; other site 868595004920 G5 box; other site 868595004921 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 868595004922 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 868595004923 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 868595004924 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 868595004925 selenocysteine synthase; Provisional; Region: PRK04311 868595004926 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 868595004927 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 868595004928 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 868595004929 catalytic residue [active] 868595004930 Transcriptional regulators [Transcription]; Region: FadR; COG2186 868595004931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 868595004932 DNA-binding site [nucleotide binding]; DNA binding site 868595004933 FCD domain; Region: FCD; pfam07729 868595004934 L-lactate permease; Region: Lactate_perm; cl00701 868595004935 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 868595004936 Predicted amidohydrolase [General function prediction only]; Region: COG0388 868595004937 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 868595004938 putative active site [active] 868595004939 catalytic triad [active] 868595004940 putative dimer interface [polypeptide binding]; other site 868595004941 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 868595004942 FAD binding site [chemical binding]; other site 868595004943 Rubrerythrin [Energy production and conversion]; Region: COG1592 868595004944 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 868595004945 binuclear metal center [ion binding]; other site 868595004946 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 868595004947 iron binding site [ion binding]; other site 868595004948 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 868595004949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004950 FeS/SAM binding site; other site 868595004951 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 868595004952 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 868595004953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595004954 FeS/SAM binding site; other site 868595004955 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 868595004956 UbiA prenyltransferase family; Region: UbiA; pfam01040 868595004957 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 868595004958 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 868595004959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595004960 S-adenosylmethionine binding site [chemical binding]; other site 868595004961 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 868595004962 substrate binding pocket [chemical binding]; other site 868595004963 aspartate-rich region 1; other site 868595004964 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 868595004965 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 868595004966 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 868595004967 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 868595004968 putative ADP-binding pocket [chemical binding]; other site 868595004969 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 868595004970 Ferredoxin [Energy production and conversion]; Region: COG1146 868595004971 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595004972 Transposase domain (DUF772); Region: DUF772; pfam05598 868595004973 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595004974 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 868595004975 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 868595004976 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 868595004977 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 868595004978 catalytic loop [active] 868595004979 iron binding site [ion binding]; other site 868595004980 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 868595004981 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 868595004982 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 868595004983 substrate binding pocket [chemical binding]; other site 868595004984 inhibitor binding site; inhibition site 868595004985 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 868595004986 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 868595004987 B12 binding site [chemical binding]; other site 868595004988 cobalt ligand [ion binding]; other site 868595004989 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 868595004990 flavoprotein, HI0933 family; Region: TIGR00275 868595004991 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 868595004992 GTP-binding protein YchF; Reviewed; Region: PRK09601 868595004993 YchF GTPase; Region: YchF; cd01900 868595004994 G1 box; other site 868595004995 GTP/Mg2+ binding site [chemical binding]; other site 868595004996 Switch I region; other site 868595004997 G2 box; other site 868595004998 Switch II region; other site 868595004999 G3 box; other site 868595005000 G4 box; other site 868595005001 G5 box; other site 868595005002 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 868595005003 Rubrerythrin [Energy production and conversion]; Region: COG1592 868595005004 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 868595005005 binuclear metal center [ion binding]; other site 868595005006 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 868595005007 iron binding site [ion binding]; other site 868595005008 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 868595005009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 868595005010 non-specific DNA binding site [nucleotide binding]; other site 868595005011 salt bridge; other site 868595005012 sequence-specific DNA binding site [nucleotide binding]; other site 868595005013 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 868595005014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595005015 active site 868595005016 phosphorylation site [posttranslational modification] 868595005017 intermolecular recognition site; other site 868595005018 dimerization interface [polypeptide binding]; other site 868595005019 PAS domain S-box; Region: sensory_box; TIGR00229 868595005020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595005021 putative active site [active] 868595005022 heme pocket [chemical binding]; other site 868595005023 PAS domain S-box; Region: sensory_box; TIGR00229 868595005024 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595005025 putative active site [active] 868595005026 heme pocket [chemical binding]; other site 868595005027 PAS domain S-box; Region: sensory_box; TIGR00229 868595005028 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595005029 putative active site [active] 868595005030 heme pocket [chemical binding]; other site 868595005031 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 868595005032 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595005033 metal binding site [ion binding]; metal-binding site 868595005034 active site 868595005035 I-site; other site 868595005036 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 868595005037 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 868595005038 DXD motif; other site 868595005039 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595005040 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 868595005041 PIN domain; Region: PIN_3; cl17397 868595005042 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 868595005043 SWIM zinc finger; Region: SWIM; pfam04434 868595005044 Transposase, Mutator family; Region: Transposase_mut; pfam00872 868595005045 MULE transposase domain; Region: MULE; pfam10551 868595005046 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 868595005047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595005048 Walker A motif; other site 868595005049 ATP binding site [chemical binding]; other site 868595005050 Walker B motif; other site 868595005051 arginine finger; other site 868595005052 Homeodomain-like domain; Region: HTH_32; pfam13565 868595005053 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 868595005054 Integrase core domain; Region: rve; pfam00665 868595005055 Integrase core domain; Region: rve_3; pfam13683 868595005056 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 868595005057 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 868595005058 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 868595005059 active site 868595005060 NTP binding site [chemical binding]; other site 868595005061 metal binding triad [ion binding]; metal-binding site 868595005062 CHASE3 domain; Region: CHASE3; cl05000 868595005063 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595005064 dimerization interface [polypeptide binding]; other site 868595005065 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 868595005066 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595005067 dimer interface [polypeptide binding]; other site 868595005068 putative CheW interface [polypeptide binding]; other site 868595005069 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 868595005070 metal-binding site [ion binding] 868595005071 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 868595005072 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 868595005073 metal-binding site [ion binding] 868595005074 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 868595005075 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 868595005076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 868595005077 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595005078 dimerization interface [polypeptide binding]; other site 868595005079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595005080 dimer interface [polypeptide binding]; other site 868595005081 phosphorylation site [posttranslational modification] 868595005082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595005083 ATP binding site [chemical binding]; other site 868595005084 Mg2+ binding site [ion binding]; other site 868595005085 G-X-G motif; other site 868595005086 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595005087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595005088 active site 868595005089 phosphorylation site [posttranslational modification] 868595005090 intermolecular recognition site; other site 868595005091 dimerization interface [polypeptide binding]; other site 868595005092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595005093 DNA binding site [nucleotide binding] 868595005094 Peptidase M15; Region: Peptidase_M15_3; cl01194 868595005095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 868595005096 YvrJ protein family; Region: YvrJ; pfam12841 868595005097 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 868595005098 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 868595005099 SWIM zinc finger; Region: SWIM; pfam04434 868595005100 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 868595005101 hypothetical protein; Validated; Region: PRK08116 868595005102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595005103 ATP binding site [chemical binding]; other site 868595005104 Walker A motif; other site 868595005105 Walker B motif; other site 868595005106 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 868595005107 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 868595005108 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 868595005109 EamA-like transporter family; Region: EamA; pfam00892 868595005110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595005111 Major Facilitator Superfamily; Region: MFS_1; pfam07690 868595005112 putative substrate translocation pore; other site 868595005113 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 868595005114 Walker A motif; other site 868595005115 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 868595005116 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 868595005117 ATP binding site [chemical binding]; other site 868595005118 substrate interface [chemical binding]; other site 868595005119 MOSC domain; Region: MOSC; pfam03473 868595005120 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 868595005121 trimer interface [polypeptide binding]; other site 868595005122 dimer interface [polypeptide binding]; other site 868595005123 putative active site [active] 868595005124 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 868595005125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595005126 FeS/SAM binding site; other site 868595005127 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 868595005128 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 868595005129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 868595005130 Walker A/P-loop; other site 868595005131 ATP binding site [chemical binding]; other site 868595005132 Q-loop/lid; other site 868595005133 ABC transporter signature motif; other site 868595005134 Walker B; other site 868595005135 D-loop; other site 868595005136 H-loop/switch region; other site 868595005137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595005138 dimer interface [polypeptide binding]; other site 868595005139 conserved gate region; other site 868595005140 putative PBP binding loops; other site 868595005141 ABC-ATPase subunit interface; other site 868595005142 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 868595005143 MoaE interaction surface [polypeptide binding]; other site 868595005144 thiocarboxylated glycine; other site 868595005145 ThiS family; Region: ThiS; pfam02597 868595005146 charged pocket; other site 868595005147 hydrophobic patch; other site 868595005148 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 868595005149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595005150 active site 868595005151 phosphorylation site [posttranslational modification] 868595005152 intermolecular recognition site; other site 868595005153 dimerization interface [polypeptide binding]; other site 868595005154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595005155 Walker A motif; other site 868595005156 ATP binding site [chemical binding]; other site 868595005157 Walker B motif; other site 868595005158 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 868595005159 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 868595005160 GAF domain; Region: GAF_3; pfam13492 868595005161 PAS fold; Region: PAS_4; pfam08448 868595005162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595005163 dimer interface [polypeptide binding]; other site 868595005164 phosphorylation site [posttranslational modification] 868595005165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595005166 ATP binding site [chemical binding]; other site 868595005167 G-X-G motif; other site 868595005168 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 868595005169 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 868595005170 putative active site [active] 868595005171 metal binding site [ion binding]; metal-binding site 868595005172 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 868595005173 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 868595005174 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 868595005175 putative active site [active] 868595005176 putative NTP binding site [chemical binding]; other site 868595005177 putative nucleic acid binding site [nucleotide binding]; other site 868595005178 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 868595005179 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 868595005180 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 868595005181 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 868595005182 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 868595005183 dimer interface [polypeptide binding]; other site 868595005184 active site 868595005185 metal binding site [ion binding]; metal-binding site 868595005186 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 868595005187 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595005188 metal binding site [ion binding]; metal-binding site 868595005189 active site 868595005190 I-site; other site 868595005191 Predicted amidohydrolase [General function prediction only]; Region: COG0388 868595005192 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 868595005193 putative active site [active] 868595005194 catalytic triad [active] 868595005195 dimer interface [polypeptide binding]; other site 868595005196 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 868595005197 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 868595005198 active site 868595005199 metal binding site [ion binding]; metal-binding site 868595005200 Transcriptional regulator [Transcription]; Region: LysR; COG0583 868595005201 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 868595005202 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 868595005203 putative dimerization interface [polypeptide binding]; other site 868595005204 Putative zinc-finger; Region: zf-HC2; pfam13490 868595005205 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 868595005206 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 868595005207 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595005208 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595005209 DNA binding residues [nucleotide binding] 868595005210 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595005211 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595005212 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595005213 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 868595005214 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 868595005215 oligomer interface [polypeptide binding]; other site 868595005216 metal binding site [ion binding]; metal-binding site 868595005217 metal binding site [ion binding]; metal-binding site 868595005218 putative Cl binding site [ion binding]; other site 868595005219 aspartate ring; other site 868595005220 basic sphincter; other site 868595005221 hydrophobic gate; other site 868595005222 periplasmic entrance; other site 868595005223 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 868595005224 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595005225 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 868595005226 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 868595005227 substrate binding site [chemical binding]; other site 868595005228 active site 868595005229 catalytic residues [active] 868595005230 heterodimer interface [polypeptide binding]; other site 868595005231 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 868595005232 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 868595005233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595005234 catalytic residue [active] 868595005235 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 868595005236 active site 868595005237 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 868595005238 active site 868595005239 ribulose/triose binding site [chemical binding]; other site 868595005240 phosphate binding site [ion binding]; other site 868595005241 substrate (anthranilate) binding pocket [chemical binding]; other site 868595005242 product (indole) binding pocket [chemical binding]; other site 868595005243 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 868595005244 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 868595005245 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 868595005246 Glutamine amidotransferase class-I; Region: GATase; pfam00117 868595005247 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 868595005248 glutamine binding [chemical binding]; other site 868595005249 catalytic triad [active] 868595005250 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 868595005251 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 868595005252 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 868595005253 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 868595005254 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 868595005255 active site 868595005256 catalytic triad [active] 868595005257 oxyanion hole [active] 868595005258 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 868595005259 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 868595005260 pyruvate kinase; Provisional; Region: PRK06354 868595005261 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 868595005262 domain interfaces; other site 868595005263 active site 868595005264 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 868595005265 6-phosphofructokinase; Provisional; Region: PRK03202 868595005266 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 868595005267 active site 868595005268 ADP/pyrophosphate binding site [chemical binding]; other site 868595005269 dimerization interface [polypeptide binding]; other site 868595005270 allosteric effector site; other site 868595005271 fructose-1,6-bisphosphate binding site; other site 868595005272 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 868595005273 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 868595005274 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 868595005275 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 868595005276 transcription attenuation protein MtrB; Provisional; Region: PRK13251 868595005277 Cation transport protein; Region: TrkH; cl17365 868595005278 TrkA-C domain; Region: TrkA_C; pfam02080 868595005279 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 868595005280 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 868595005281 active site 868595005282 PHP Thumb interface [polypeptide binding]; other site 868595005283 metal binding site [ion binding]; metal-binding site 868595005284 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 868595005285 generic binding surface II; other site 868595005286 generic binding surface I; other site 868595005287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 868595005288 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 868595005289 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 868595005290 NlpC/P60 family; Region: NLPC_P60; pfam00877 868595005291 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 868595005292 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595005293 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595005294 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 868595005295 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 868595005296 DNA binding residues [nucleotide binding] 868595005297 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 868595005298 catalytic residues [active] 868595005299 catalytic nucleophile [active] 868595005300 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 868595005301 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 868595005302 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 868595005303 Uncharacterized conserved protein [Function unknown]; Region: COG1543 868595005304 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 868595005305 active site 868595005306 substrate binding site [chemical binding]; other site 868595005307 catalytic site [active] 868595005308 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 868595005309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 868595005310 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 868595005311 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 868595005312 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 868595005313 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 868595005314 minor groove reading motif; other site 868595005315 helix-hairpin-helix signature motif; other site 868595005316 substrate binding pocket [chemical binding]; other site 868595005317 active site 868595005318 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 868595005319 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 868595005320 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 868595005321 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 868595005322 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 868595005323 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 868595005324 active site 868595005325 Substrate binding site; other site 868595005326 Mg++ binding site; other site 868595005327 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 868595005328 putative CoA binding site [chemical binding]; other site 868595005329 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 868595005330 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 868595005331 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 868595005332 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 868595005333 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 868595005334 Carbohydrate binding domain; Region: CBM_25; smart01066 868595005335 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 868595005336 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 868595005337 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 868595005338 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 868595005339 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 868595005340 tartrate dehydrogenase; Region: TTC; TIGR02089 868595005341 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 868595005342 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 868595005343 substrate binding site [chemical binding]; other site 868595005344 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 868595005345 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 868595005346 substrate binding site [chemical binding]; other site 868595005347 ligand binding site [chemical binding]; other site 868595005348 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 868595005349 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 868595005350 active site 868595005351 catalytic residues [active] 868595005352 metal binding site [ion binding]; metal-binding site 868595005353 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 868595005354 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 868595005355 GatB domain; Region: GatB_Yqey; smart00845 868595005356 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 868595005357 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 868595005358 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 868595005359 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 868595005360 homotrimer interaction site [polypeptide binding]; other site 868595005361 putative active site [active] 868595005362 S-layer homology domain; Region: SLH; pfam00395 868595005363 S-layer homology domain; Region: SLH; pfam00395 868595005364 PQQ-like domain; Region: PQQ_2; pfam13360 868595005365 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 868595005366 active site 868595005367 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 868595005368 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 868595005369 nucleotide binding pocket [chemical binding]; other site 868595005370 K-X-D-G motif; other site 868595005371 catalytic site [active] 868595005372 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 868595005373 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 868595005374 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 868595005375 Dimer interface [polypeptide binding]; other site 868595005376 BRCT sequence motif; other site 868595005377 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 868595005378 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 868595005379 Part of AAA domain; Region: AAA_19; pfam13245 868595005380 Family description; Region: UvrD_C_2; pfam13538 868595005381 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 868595005382 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 868595005383 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 868595005384 metal binding site [ion binding]; metal-binding site 868595005385 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 868595005386 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 868595005387 substrate binding site [chemical binding]; other site 868595005388 glutamase interaction surface [polypeptide binding]; other site 868595005389 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 868595005390 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 868595005391 catalytic residues [active] 868595005392 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 868595005393 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 868595005394 putative active site [active] 868595005395 oxyanion strand; other site 868595005396 catalytic triad [active] 868595005397 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 868595005398 putative active site pocket [active] 868595005399 4-fold oligomerization interface [polypeptide binding]; other site 868595005400 metal binding residues [ion binding]; metal-binding site 868595005401 3-fold/trimer interface [polypeptide binding]; other site 868595005402 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595005403 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595005404 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 868595005405 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595005406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595005407 homodimer interface [polypeptide binding]; other site 868595005408 catalytic residue [active] 868595005409 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 868595005410 histidinol dehydrogenase; Region: hisD; TIGR00069 868595005411 NAD binding site [chemical binding]; other site 868595005412 dimerization interface [polypeptide binding]; other site 868595005413 product binding site; other site 868595005414 substrate binding site [chemical binding]; other site 868595005415 zinc binding site [ion binding]; other site 868595005416 catalytic residues [active] 868595005417 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 868595005418 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 868595005419 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 868595005420 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 868595005421 dimer interface [polypeptide binding]; other site 868595005422 motif 1; other site 868595005423 active site 868595005424 motif 2; other site 868595005425 motif 3; other site 868595005426 Trp repressor protein; Region: Trp_repressor; cl17266 868595005427 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 868595005428 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 868595005429 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 868595005430 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 868595005431 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 868595005432 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 868595005433 purine monophosphate binding site [chemical binding]; other site 868595005434 dimer interface [polypeptide binding]; other site 868595005435 putative catalytic residues [active] 868595005436 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 868595005437 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 868595005438 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 868595005439 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 868595005440 active site 868595005441 substrate binding site [chemical binding]; other site 868595005442 cosubstrate binding site; other site 868595005443 catalytic site [active] 868595005444 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 868595005445 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 868595005446 dimerization interface [polypeptide binding]; other site 868595005447 putative ATP binding site [chemical binding]; other site 868595005448 amidophosphoribosyltransferase; Provisional; Region: PRK05793 868595005449 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 868595005450 active site 868595005451 tetramer interface [polypeptide binding]; other site 868595005452 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595005453 active site 868595005454 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 868595005455 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 868595005456 dimerization interface [polypeptide binding]; other site 868595005457 ATP binding site [chemical binding]; other site 868595005458 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 868595005459 dimerization interface [polypeptide binding]; other site 868595005460 ATP binding site [chemical binding]; other site 868595005461 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 868595005462 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 868595005463 putative active site [active] 868595005464 catalytic triad [active] 868595005465 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 868595005466 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 868595005467 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 868595005468 ATP binding site [chemical binding]; other site 868595005469 active site 868595005470 substrate binding site [chemical binding]; other site 868595005471 adenylosuccinate lyase; Provisional; Region: PRK07492 868595005472 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 868595005473 tetramer interface [polypeptide binding]; other site 868595005474 active site 868595005475 AIR carboxylase; Region: AIRC; pfam00731 868595005476 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 868595005477 GMP synthase; Reviewed; Region: guaA; PRK00074 868595005478 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 868595005479 AMP/PPi binding site [chemical binding]; other site 868595005480 candidate oxyanion hole; other site 868595005481 catalytic triad [active] 868595005482 potential glutamine specificity residues [chemical binding]; other site 868595005483 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 868595005484 ATP Binding subdomain [chemical binding]; other site 868595005485 Ligand Binding sites [chemical binding]; other site 868595005486 Dimerization subdomain; other site 868595005487 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 868595005488 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595005489 active site 868595005490 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 868595005491 homodimer interface [polypeptide binding]; other site 868595005492 metal binding site [ion binding]; metal-binding site 868595005493 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 868595005494 CheC-like family; Region: CheC; pfam04509 868595005495 CheC-like family; Region: CheC; pfam04509 868595005496 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 868595005497 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 868595005498 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 868595005499 Response regulator receiver domain; Region: Response_reg; pfam00072 868595005500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595005501 active site 868595005502 phosphorylation site [posttranslational modification] 868595005503 intermolecular recognition site; other site 868595005504 dimerization interface [polypeptide binding]; other site 868595005505 Transposase domain (DUF772); Region: DUF772; pfam05598 868595005506 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595005507 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 868595005508 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 868595005509 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 868595005510 CheC-like family; Region: CheC; pfam04509 868595005511 CheC-like family; Region: CheC; pfam04509 868595005512 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 868595005513 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 868595005514 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 868595005515 CheD chemotactic sensory transduction; Region: CheD; cl00810 868595005516 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 868595005517 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 868595005518 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 868595005519 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 868595005520 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 868595005521 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595005522 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 868595005523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595005524 DNA binding residues [nucleotide binding] 868595005525 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 868595005526 Flagellar protein YcgR; Region: YcgR_2; pfam12945 868595005527 PilZ domain; Region: PilZ; pfam07238 868595005528 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 868595005529 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 868595005530 P-loop; other site 868595005531 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 868595005532 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 868595005533 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 868595005534 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 868595005535 FHIPEP family; Region: FHIPEP; pfam00771 868595005536 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 868595005537 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 868595005538 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 868595005539 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 868595005540 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 868595005541 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 868595005542 flagellar motor switch protein FliN; Region: fliN; TIGR02480 868595005543 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 868595005544 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 868595005545 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 868595005546 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 868595005547 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 868595005548 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 868595005549 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 868595005550 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 868595005551 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 868595005552 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 868595005553 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 868595005554 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 868595005555 Walker A motif/ATP binding site; other site 868595005556 Walker B motif; other site 868595005557 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 868595005558 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 868595005559 Flagellar assembly protein FliH; Region: FliH; pfam02108 868595005560 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 868595005561 FliG C-terminal domain; Region: FliG_C; pfam01706 868595005562 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 868595005563 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 868595005564 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 868595005565 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 868595005566 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 868595005567 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 868595005568 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 868595005569 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 868595005570 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 868595005571 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 868595005572 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 868595005573 inhibitor-cofactor binding pocket; inhibition site 868595005574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595005575 catalytic residue [active] 868595005576 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 868595005577 active site 868595005578 NTP binding site [chemical binding]; other site 868595005579 metal binding triad [ion binding]; metal-binding site 868595005580 antibiotic binding site [chemical binding]; other site 868595005581 Protein of unknown function DUF86; Region: DUF86; pfam01934 868595005582 FlaG protein; Region: FlaG; pfam03646 868595005583 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 868595005584 FliW protein; Region: FliW; pfam02623 868595005585 Global regulator protein family; Region: CsrA; pfam02599 868595005586 flagellar capping protein; Validated; Region: fliD; PRK07737 868595005587 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 868595005588 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 868595005589 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 868595005590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 868595005591 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 868595005592 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 868595005593 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 868595005594 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595005595 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595005596 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 868595005597 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 868595005598 DNA binding residues [nucleotide binding] 868595005599 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 868595005600 catalytic residues [active] 868595005601 catalytic nucleophile [active] 868595005602 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 868595005603 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 868595005604 Putative motility protein; Region: YjfB_motility; pfam14070 868595005605 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 868595005606 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 868595005607 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 868595005608 FlaG protein; Region: FlaG; cl00591 868595005609 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 868595005610 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 868595005611 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 868595005612 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 868595005613 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 868595005614 FlgN protein; Region: FlgN; pfam05130 868595005615 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 868595005616 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 868595005617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595005618 active site 868595005619 phosphorylation site [posttranslational modification] 868595005620 intermolecular recognition site; other site 868595005621 dimerization interface [polypeptide binding]; other site 868595005622 CheB methylesterase; Region: CheB_methylest; pfam01339 868595005623 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 868595005624 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 868595005625 putative binding surface; other site 868595005626 active site 868595005627 P2 response regulator binding domain; Region: P2; pfam07194 868595005628 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 868595005629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595005630 ATP binding site [chemical binding]; other site 868595005631 Mg2+ binding site [ion binding]; other site 868595005632 G-X-G motif; other site 868595005633 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 868595005634 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 868595005635 putative CheA interaction surface; other site 868595005636 flagellar motor protein MotD; Reviewed; Region: PRK09038 868595005637 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 868595005638 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 868595005639 ligand binding site [chemical binding]; other site 868595005640 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 868595005641 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 868595005642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 868595005643 Transposase; Region: DEDD_Tnp_IS110; pfam01548 868595005644 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 868595005645 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 868595005646 helix-hairpin-helix signature motif; other site 868595005647 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 868595005648 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 868595005649 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 868595005650 active site 868595005651 8-oxo-dGMP binding site [chemical binding]; other site 868595005652 nudix motif; other site 868595005653 metal binding site [ion binding]; metal-binding site 868595005654 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 868595005655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 868595005656 motif II; other site 868595005657 Transposase domain (DUF772); Region: DUF772; pfam05598 868595005658 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595005659 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 868595005660 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 868595005661 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 868595005662 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 868595005663 RNA/DNA hybrid binding site [nucleotide binding]; other site 868595005664 active site 868595005665 oligoendopeptidase F; Region: pepF; TIGR00181 868595005666 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 868595005667 active site 868595005668 Zn binding site [ion binding]; other site 868595005669 Uncharacterized conserved protein [Function unknown]; Region: COG0327 868595005670 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 868595005671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 868595005672 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 868595005673 Uncharacterized conserved protein [Function unknown]; Region: COG0327 868595005674 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 868595005675 Family of unknown function (DUF633); Region: DUF633; pfam04816 868595005676 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 868595005677 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595005678 dimerization interface [polypeptide binding]; other site 868595005679 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595005680 dimer interface [polypeptide binding]; other site 868595005681 putative CheW interface [polypeptide binding]; other site 868595005682 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 868595005683 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 868595005684 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 868595005685 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595005686 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 868595005687 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595005688 DNA binding residues [nucleotide binding] 868595005689 DNA primase; Validated; Region: dnaG; PRK05667 868595005690 CHC2 zinc finger; Region: zf-CHC2; pfam01807 868595005691 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 868595005692 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 868595005693 active site 868595005694 metal binding site [ion binding]; metal-binding site 868595005695 interdomain interaction site; other site 868595005696 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 868595005697 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 868595005698 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595005699 Zn2+ binding site [ion binding]; other site 868595005700 Mg2+ binding site [ion binding]; other site 868595005701 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 868595005702 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 868595005703 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 868595005704 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 868595005705 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 868595005706 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 868595005707 pyruvate phosphate dikinase; Provisional; Region: PRK09279 868595005708 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 868595005709 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 868595005710 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 868595005711 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 868595005712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595005713 dimerization interface [polypeptide binding]; other site 868595005714 putative Zn2+ binding site [ion binding]; other site 868595005715 putative DNA binding site [nucleotide binding]; other site 868595005716 FOG: CBS domain [General function prediction only]; Region: COG0517 868595005717 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 868595005718 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 868595005719 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 868595005720 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 868595005721 dimer interface [polypeptide binding]; other site 868595005722 motif 1; other site 868595005723 active site 868595005724 motif 2; other site 868595005725 motif 3; other site 868595005726 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 868595005727 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 868595005728 Recombination protein O N terminal; Region: RecO_N; pfam11967 868595005729 Recombination protein O C terminal; Region: RecO_C; pfam02565 868595005730 Rubrerythrin [Energy production and conversion]; Region: COG1592 868595005731 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 868595005732 diiron binding motif [ion binding]; other site 868595005733 S-layer homology domain; Region: SLH; pfam00395 868595005734 S-layer homology domain; Region: SLH; pfam00395 868595005735 GTPase Era; Reviewed; Region: era; PRK00089 868595005736 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 868595005737 G1 box; other site 868595005738 GTP/Mg2+ binding site [chemical binding]; other site 868595005739 Switch I region; other site 868595005740 G2 box; other site 868595005741 Switch II region; other site 868595005742 G3 box; other site 868595005743 G4 box; other site 868595005744 G5 box; other site 868595005745 KH domain; Region: KH_2; pfam07650 868595005746 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 868595005747 active site 868595005748 catalytic motif [active] 868595005749 Zn binding site [ion binding]; other site 868595005750 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 868595005751 metal-binding heat shock protein; Provisional; Region: PRK00016 868595005752 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 868595005753 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 868595005754 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595005755 Zn2+ binding site [ion binding]; other site 868595005756 Mg2+ binding site [ion binding]; other site 868595005757 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 868595005758 PhoH-like protein; Region: PhoH; pfam02562 868595005759 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 868595005760 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 868595005761 YabP family; Region: YabP; cl06766 868595005762 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 868595005763 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 868595005764 nucleotide binding site/active site [active] 868595005765 HIT family signature motif; other site 868595005766 catalytic residue [active] 868595005767 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 868595005768 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 868595005769 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595005770 FeS/SAM binding site; other site 868595005771 TRAM domain; Region: TRAM; cl01282 868595005772 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 868595005773 RNA methyltransferase, RsmE family; Region: TIGR00046 868595005774 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 868595005775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595005776 S-adenosylmethionine binding site [chemical binding]; other site 868595005777 chaperone protein DnaJ; Provisional; Region: PRK10767 868595005778 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 868595005779 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 868595005780 substrate binding site [polypeptide binding]; other site 868595005781 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 868595005782 Zn binding sites [ion binding]; other site 868595005783 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 868595005784 dimer interface [polypeptide binding]; other site 868595005785 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 868595005786 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 868595005787 nucleotide binding site [chemical binding]; other site 868595005788 NEF interaction site [polypeptide binding]; other site 868595005789 SBD interface [polypeptide binding]; other site 868595005790 GrpE; Region: GrpE; pfam01025 868595005791 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 868595005792 dimer interface [polypeptide binding]; other site 868595005793 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 868595005794 chaperonin families, type I and type II. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The...; Region: chaperonin_type_I_II; cd00309 868595005795 thermosome, various subunits, archaeal; Region: thermosome_arch; TIGR02339 868595005796 ATP/Mg binding site [chemical binding]; other site 868595005797 ring oligomerisation interface [polypeptide binding]; other site 868595005798 hinge regions; other site 868595005799 stacking interactions; other site 868595005800 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 868595005801 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 868595005802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595005803 FeS/SAM binding site; other site 868595005804 HemN C-terminal domain; Region: HemN_C; pfam06969 868595005805 GTP-binding protein LepA; Provisional; Region: PRK05433 868595005806 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 868595005807 G1 box; other site 868595005808 putative GEF interaction site [polypeptide binding]; other site 868595005809 GTP/Mg2+ binding site [chemical binding]; other site 868595005810 Switch I region; other site 868595005811 G2 box; other site 868595005812 G3 box; other site 868595005813 Switch II region; other site 868595005814 G4 box; other site 868595005815 G5 box; other site 868595005816 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 868595005817 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 868595005818 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 868595005819 stage II sporulation protein P; Region: spore_II_P; TIGR02867 868595005820 Membrane protein of unknown function; Region: DUF360; cl00850 868595005821 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 868595005822 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 868595005823 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 868595005824 Domain of unknown function DUF77; Region: DUF77; pfam01910 868595005825 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595005826 AMIN domain; Region: AMIN; pfam11741 868595005827 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 868595005828 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 868595005829 active site 868595005830 metal binding site [ion binding]; metal-binding site 868595005831 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 868595005832 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 868595005833 Competence protein; Region: Competence; pfam03772 868595005834 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 868595005835 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 868595005836 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 868595005837 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 868595005838 N-acetyl-D-glucosamine binding site [chemical binding]; other site 868595005839 catalytic residue [active] 868595005840 SLBB domain; Region: SLBB; pfam10531 868595005841 Helix-hairpin-helix motif; Region: HHH; pfam00633 868595005842 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 868595005843 Predicted membrane protein [Function unknown]; Region: COG2323 868595005844 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 868595005845 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 868595005846 HIGH motif; other site 868595005847 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 868595005848 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 868595005849 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 868595005850 active site 868595005851 KMSKS motif; other site 868595005852 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 868595005853 tRNA binding surface [nucleotide binding]; other site 868595005854 AMP-binding domain protein; Validated; Region: PRK08315 868595005855 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 868595005856 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 868595005857 acyl-activating enzyme (AAE) consensus motif; other site 868595005858 putative AMP binding site [chemical binding]; other site 868595005859 putative active site [active] 868595005860 putative CoA binding site [chemical binding]; other site 868595005861 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 868595005862 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595005863 Zn2+ binding site [ion binding]; other site 868595005864 Mg2+ binding site [ion binding]; other site 868595005865 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 868595005866 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 868595005867 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 868595005868 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 868595005869 active site 868595005870 (T/H)XGH motif; other site 868595005871 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 868595005872 nucleotide binding site/active site [active] 868595005873 HIT family signature motif; other site 868595005874 catalytic residue [active] 868595005875 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 868595005876 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 868595005877 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 868595005878 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 868595005879 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 868595005880 ligand binding site [chemical binding]; other site 868595005881 dimerization interface [polypeptide binding]; other site 868595005882 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 868595005883 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 868595005884 TM-ABC transporter signature motif; other site 868595005885 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 868595005886 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 868595005887 Walker A/P-loop; other site 868595005888 ATP binding site [chemical binding]; other site 868595005889 Q-loop/lid; other site 868595005890 ABC transporter signature motif; other site 868595005891 Walker B; other site 868595005892 D-loop; other site 868595005893 H-loop/switch region; other site 868595005894 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 868595005895 D-ribose pyranase; Provisional; Region: PRK11797 868595005896 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 868595005897 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 868595005898 substrate binding site [chemical binding]; other site 868595005899 dimer interface [polypeptide binding]; other site 868595005900 ATP binding site [chemical binding]; other site 868595005901 Transcriptional regulators [Transcription]; Region: PurR; COG1609 868595005902 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 868595005903 DNA binding site [nucleotide binding] 868595005904 domain linker motif; other site 868595005905 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 868595005906 dimerization interface [polypeptide binding]; other site 868595005907 ligand binding site [chemical binding]; other site 868595005908 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 868595005909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 868595005910 Integrase core domain; Region: rve; pfam00665 868595005911 transposase/IS protein; Provisional; Region: PRK09183 868595005912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595005913 Walker A motif; other site 868595005914 ATP binding site [chemical binding]; other site 868595005915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595005916 putative substrate translocation pore; other site 868595005917 Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133 868595005918 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 868595005919 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 868595005920 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 868595005921 Walker A/P-loop; other site 868595005922 ATP binding site [chemical binding]; other site 868595005923 Q-loop/lid; other site 868595005924 ABC transporter signature motif; other site 868595005925 Walker B; other site 868595005926 D-loop; other site 868595005927 H-loop/switch region; other site 868595005928 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 868595005929 cobalt transport protein CbiM; Validated; Region: PRK06265 868595005930 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 868595005931 PDGLE domain; Region: PDGLE; pfam13190 868595005932 benzoate transporter; Region: benE; TIGR00843 868595005933 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 868595005934 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 868595005935 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 868595005936 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 868595005937 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 868595005938 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 868595005939 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 868595005940 active site 868595005941 catalytic residues [active] 868595005942 metal binding site [ion binding]; metal-binding site 868595005943 DmpG-like communication domain; Region: DmpG_comm; pfam07836 868595005944 acetaldehyde dehydrogenase; Validated; Region: PRK08300 868595005945 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 868595005946 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 868595005947 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 868595005948 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 868595005949 Probable molybdopterin binding domain; Region: MoCF_biosynth; pfam00994 868595005950 MPT binding site; other site 868595005951 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05848 868595005952 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 868595005953 active site 868595005954 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 868595005955 Transcriptional regulator [Transcription]; Region: IclR; COG1414 868595005956 Bacterial transcriptional regulator; Region: IclR; pfam01614 868595005957 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 868595005958 Flavoprotein; Region: Flavoprotein; pfam02441 868595005959 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 868595005960 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 868595005961 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 868595005962 active site 868595005963 hypothetical protein; Provisional; Region: PRK04194 868595005964 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 868595005965 AIR carboxylase; Region: AIRC; smart01001 868595005966 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 868595005967 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 868595005968 Ligand Binding Site [chemical binding]; other site 868595005969 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595005970 dimer interface [polypeptide binding]; other site 868595005971 putative CheW interface [polypeptide binding]; other site 868595005972 ThiS family; Region: ThiS; pfam02597 868595005973 charged pocket; other site 868595005974 hydrophobic patch; other site 868595005975 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 868595005976 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 868595005977 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 868595005978 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 868595005979 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595005980 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 868595005981 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 868595005982 active site 868595005983 metal binding site [ion binding]; metal-binding site 868595005984 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 868595005985 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 868595005986 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 868595005987 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 868595005988 ligand binding site [chemical binding]; other site 868595005989 flexible hinge region; other site 868595005990 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 868595005991 putative switch regulator; other site 868595005992 non-specific DNA interactions [nucleotide binding]; other site 868595005993 DNA binding site [nucleotide binding] 868595005994 sequence specific DNA binding site [nucleotide binding]; other site 868595005995 putative cAMP binding site [chemical binding]; other site 868595005996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 868595005997 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 868595005998 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595005999 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 868595006000 active site 868595006001 substrate binding site [chemical binding]; other site 868595006002 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 868595006003 FMN binding site [chemical binding]; other site 868595006004 putative catalytic residues [active] 868595006005 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 868595006006 FOG: CBS domain [General function prediction only]; Region: COG0517 868595006007 FOG: CBS domain [General function prediction only]; Region: COG0517 868595006008 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 868595006009 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 868595006010 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 868595006011 dimer interface [polypeptide binding]; other site 868595006012 substrate binding site [chemical binding]; other site 868595006013 ATP binding site [chemical binding]; other site 868595006014 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 868595006015 MarR family; Region: MarR_2; pfam12802 868595006016 Methyltransferase domain; Region: Methyltransf_23; pfam13489 868595006017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595006018 S-adenosylmethionine binding site [chemical binding]; other site 868595006019 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 868595006020 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 868595006021 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 868595006022 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 868595006023 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 868595006024 putative L-serine binding site [chemical binding]; other site 868595006025 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 868595006026 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595006027 dimerization interface [polypeptide binding]; other site 868595006028 putative Zn2+ binding site [ion binding]; other site 868595006029 putative DNA binding site [nucleotide binding]; other site 868595006030 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 868595006031 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 868595006032 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 868595006033 acyl-activating enzyme (AAE) consensus motif; other site 868595006034 AMP binding site [chemical binding]; other site 868595006035 active site 868595006036 CoA binding site [chemical binding]; other site 868595006037 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 868595006038 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 868595006039 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 868595006040 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 868595006041 dimer interface [polypeptide binding]; other site 868595006042 PYR/PP interface [polypeptide binding]; other site 868595006043 TPP binding site [chemical binding]; other site 868595006044 substrate binding site [chemical binding]; other site 868595006045 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 868595006046 TPP-binding site; other site 868595006047 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 868595006048 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 868595006049 CPxP motif; other site 868595006050 selenophosphate synthetase; Provisional; Region: PRK00943 868595006051 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 868595006052 dimerization interface [polypeptide binding]; other site 868595006053 putative ATP binding site [chemical binding]; other site 868595006054 glutamate racemase; Provisional; Region: PRK00865 868595006055 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 868595006056 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 868595006057 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 868595006058 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 868595006059 ABC1 family; Region: ABC1; cl17513 868595006060 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 868595006061 oligomeric interface; other site 868595006062 putative active site [active] 868595006063 homodimer interface [polypeptide binding]; other site 868595006064 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 868595006065 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 868595006066 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 868595006067 putative catalytic site [active] 868595006068 putative phosphate binding site [ion binding]; other site 868595006069 active site 868595006070 metal binding site A [ion binding]; metal-binding site 868595006071 DNA binding site [nucleotide binding] 868595006072 putative AP binding site [nucleotide binding]; other site 868595006073 putative metal binding site B [ion binding]; other site 868595006074 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 868595006075 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 868595006076 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595006077 Zn2+ binding site [ion binding]; other site 868595006078 Mg2+ binding site [ion binding]; other site 868595006079 Uncharacterized conserved protein [Function unknown]; Region: COG1751 868595006080 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 868595006081 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595006082 dimer interface [polypeptide binding]; other site 868595006083 putative CheW interface [polypeptide binding]; other site 868595006084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 868595006085 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 868595006086 Ion channel; Region: Ion_trans_2; pfam07885 868595006087 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 868595006088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595006089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 868595006090 Coenzyme A binding pocket [chemical binding]; other site 868595006091 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 868595006092 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 868595006093 ACS interaction site; other site 868595006094 CODH interaction site; other site 868595006095 cubane metal cluster (B-cluster) [ion binding]; other site 868595006096 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 868595006097 gamma-glutamyl kinase; Provisional; Region: PRK05429 868595006098 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 868595006099 nucleotide binding site [chemical binding]; other site 868595006100 homotetrameric interface [polypeptide binding]; other site 868595006101 putative phosphate binding site [ion binding]; other site 868595006102 putative allosteric binding site; other site 868595006103 PUA domain; Region: PUA; pfam01472 868595006104 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 868595006105 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 868595006106 putative catalytic cysteine [active] 868595006107 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 868595006108 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 868595006109 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 868595006110 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 868595006111 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595006112 metal binding site [ion binding]; metal-binding site 868595006113 active site 868595006114 I-site; other site 868595006115 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 868595006116 dimer interface [polypeptide binding]; other site 868595006117 [2Fe-2S] cluster binding site [ion binding]; other site 868595006118 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 868595006119 SLBB domain; Region: SLBB; pfam10531 868595006120 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 868595006121 4Fe-4S binding domain; Region: Fer4; pfam00037 868595006122 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 868595006123 4Fe-4S binding domain; Region: Fer4; pfam00037 868595006124 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 868595006125 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 868595006126 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595006127 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595006128 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 868595006129 aspartate kinase; Reviewed; Region: PRK06635 868595006130 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 868595006131 putative nucleotide binding site [chemical binding]; other site 868595006132 putative catalytic residues [active] 868595006133 putative Mg ion binding site [ion binding]; other site 868595006134 putative aspartate binding site [chemical binding]; other site 868595006135 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 868595006136 putative allosteric regulatory site; other site 868595006137 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 868595006138 putative allosteric regulatory residue; other site 868595006139 homoserine kinase; Provisional; Region: PRK01212 868595006140 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 868595006141 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 868595006142 homoserine dehydrogenase; Provisional; Region: PRK06349 868595006143 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 868595006144 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 868595006145 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 868595006146 hypothetical protein; Provisional; Region: PRK04435 868595006147 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 868595006148 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 868595006149 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 868595006150 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 868595006151 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 868595006152 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 868595006153 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 868595006154 GTP-binding protein Der; Reviewed; Region: PRK00093 868595006155 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 868595006156 G1 box; other site 868595006157 GTP/Mg2+ binding site [chemical binding]; other site 868595006158 Switch I region; other site 868595006159 G2 box; other site 868595006160 Switch II region; other site 868595006161 G3 box; other site 868595006162 G4 box; other site 868595006163 G5 box; other site 868595006164 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 868595006165 G1 box; other site 868595006166 GTP/Mg2+ binding site [chemical binding]; other site 868595006167 Switch I region; other site 868595006168 G2 box; other site 868595006169 G3 box; other site 868595006170 Switch II region; other site 868595006171 G4 box; other site 868595006172 G5 box; other site 868595006173 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 868595006174 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 868595006175 Protein of unknown function (DUF512); Region: DUF512; pfam04459 868595006176 YIEGIA protein; Region: YIEGIA; pfam14045 868595006177 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 868595006178 stage II sporulation protein P; Region: spore_II_P; TIGR02867 868595006179 Protein of unknown function (DUF1614); Region: DUF1614; cl15407 868595006180 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 868595006181 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 868595006182 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 868595006183 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 868595006184 RNA binding site [nucleotide binding]; other site 868595006185 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 868595006186 RNA binding site [nucleotide binding]; other site 868595006187 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 868595006188 RNA binding site [nucleotide binding]; other site 868595006189 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 868595006190 RNA binding site [nucleotide binding]; other site 868595006191 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 868595006192 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 868595006193 putative acyl-acceptor binding pocket; other site 868595006194 cytidylate kinase; Provisional; Region: cmk; PRK00023 868595006195 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 868595006196 CMP-binding site; other site 868595006197 The sites determining sugar specificity; other site 868595006198 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 868595006199 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 868595006200 hinge; other site 868595006201 active site 868595006202 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 868595006203 prephenate dehydrogenase; Validated; Region: PRK08507 868595006204 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 868595006205 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 868595006206 aspartate aminotransferase; Provisional; Region: PRK06836 868595006207 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595006208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595006209 homodimer interface [polypeptide binding]; other site 868595006210 catalytic residue [active] 868595006211 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 868595006212 homotrimer interaction site [polypeptide binding]; other site 868595006213 active site 868595006214 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 868595006215 hexamer interface [polypeptide binding]; other site 868595006216 RNA binding site [nucleotide binding]; other site 868595006217 Histidine-zinc binding site [chemical binding]; other site 868595006218 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 868595006219 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595006220 RNA binding surface [nucleotide binding]; other site 868595006221 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 868595006222 active site 868595006223 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 868595006224 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 868595006225 Peptidase family U32; Region: Peptidase_U32; cl03113 868595006226 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 868595006227 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595006228 putative active site [active] 868595006229 heme pocket [chemical binding]; other site 868595006230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595006231 dimer interface [polypeptide binding]; other site 868595006232 phosphorylation site [posttranslational modification] 868595006233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595006234 ATP binding site [chemical binding]; other site 868595006235 G-X-G motif; other site 868595006236 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 868595006237 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 868595006238 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 868595006239 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 868595006240 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 868595006241 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 868595006242 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 868595006243 active site 868595006244 HIGH motif; other site 868595006245 dimer interface [polypeptide binding]; other site 868595006246 KMSKS motif; other site 868595006247 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 868595006248 Peptidase family M50; Region: Peptidase_M50; pfam02163 868595006249 active site 868595006250 putative substrate binding region [chemical binding]; other site 868595006251 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 868595006252 DHH family; Region: DHH; pfam01368 868595006253 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 868595006254 FOG: CBS domain [General function prediction only]; Region: COG0517 868595006255 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 868595006256 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 868595006257 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 868595006258 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 868595006259 active site 868595006260 NTP binding site [chemical binding]; other site 868595006261 metal binding triad [ion binding]; metal-binding site 868595006262 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 868595006263 diaminopimelate decarboxylase; Region: lysA; TIGR01048 868595006264 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 868595006265 active site 868595006266 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 868595006267 substrate binding site [chemical binding]; other site 868595006268 catalytic residues [active] 868595006269 dimer interface [polypeptide binding]; other site 868595006270 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 868595006271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 868595006272 non-specific DNA binding site [nucleotide binding]; other site 868595006273 salt bridge; other site 868595006274 sequence-specific DNA binding site [nucleotide binding]; other site 868595006275 Domain of unknown function (DUF955); Region: DUF955; cl01076 868595006276 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 868595006277 EamA-like transporter family; Region: EamA; pfam00892 868595006278 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 868595006279 EamA-like transporter family; Region: EamA; pfam00892 868595006280 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 868595006281 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 868595006282 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 868595006283 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 868595006284 RNA binding site [nucleotide binding]; other site 868595006285 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 868595006286 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 868595006287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 868595006288 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 868595006289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 868595006290 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 868595006291 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 868595006292 catalytic loop [active] 868595006293 iron binding site [ion binding]; other site 868595006294 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 868595006295 4Fe-4S binding domain; Region: Fer4_6; pfam12837 868595006296 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 868595006297 [4Fe-4S] binding site [ion binding]; other site 868595006298 molybdopterin cofactor binding site; other site 868595006299 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 868595006300 molybdopterin cofactor binding site; other site 868595006301 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 868595006302 dimer interface [polypeptide binding]; other site 868595006303 [2Fe-2S] cluster binding site [ion binding]; other site 868595006304 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 868595006305 SLBB domain; Region: SLBB; pfam10531 868595006306 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 868595006307 4Fe-4S binding domain; Region: Fer4; pfam00037 868595006308 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 868595006309 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 868595006310 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 868595006311 putative dimer interface [polypeptide binding]; other site 868595006312 [2Fe-2S] cluster binding site [ion binding]; other site 868595006313 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 868595006314 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 868595006315 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 868595006316 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 868595006317 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 868595006318 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 868595006319 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 868595006320 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 868595006321 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 868595006322 molybdopterin cofactor binding site; other site 868595006323 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 868595006324 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 868595006325 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 868595006326 molybdopterin cofactor binding site; other site 868595006327 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 868595006328 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 868595006329 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 868595006330 GTP binding site; other site 868595006331 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 868595006332 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 868595006333 sporulation sigma factor SigF; Validated; Region: PRK05572 868595006334 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595006335 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 868595006336 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595006337 DNA binding residues [nucleotide binding] 868595006338 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 868595006339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595006340 ATP binding site [chemical binding]; other site 868595006341 Mg2+ binding site [ion binding]; other site 868595006342 G-X-G motif; other site 868595006343 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 868595006344 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 868595006345 anti sigma factor interaction site; other site 868595006346 regulatory phosphorylation site [posttranslational modification]; other site 868595006347 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 868595006348 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 868595006349 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 868595006350 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 868595006351 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 868595006352 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 868595006353 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 868595006354 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 868595006355 phosphopentomutase; Provisional; Region: PRK05362 868595006356 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 868595006357 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 868595006358 active site 868595006359 Int/Topo IB signature motif; other site 868595006360 Protein of unknown function (DUF441); Region: DUF441; pfam04284 868595006361 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 868595006362 Integral membrane protein DUF95; Region: DUF95; cl00572 868595006363 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 868595006364 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 868595006365 peptidase T-like protein; Region: PepT-like; TIGR01883 868595006366 metal binding site [ion binding]; metal-binding site 868595006367 putative dimer interface [polypeptide binding]; other site 868595006368 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 868595006369 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 868595006370 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 868595006371 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 868595006372 TPP-binding site [chemical binding]; other site 868595006373 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 868595006374 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 868595006375 dimer interface [polypeptide binding]; other site 868595006376 PYR/PP interface [polypeptide binding]; other site 868595006377 TPP binding site [chemical binding]; other site 868595006378 substrate binding site [chemical binding]; other site 868595006379 Ferredoxin [Energy production and conversion]; Region: COG1146 868595006380 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595006381 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 868595006382 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 868595006383 putative catalytic motif [active] 868595006384 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 868595006385 Ligand binding site; other site 868595006386 Putative Catalytic site; other site 868595006387 DXD motif; other site 868595006388 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 868595006389 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 868595006390 Thiamine pyrophosphokinase; Region: TPK; cl08415 868595006391 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 868595006392 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 868595006393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595006394 active site 868595006395 phosphorylation site [posttranslational modification] 868595006396 intermolecular recognition site; other site 868595006397 dimerization interface [polypeptide binding]; other site 868595006398 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 868595006399 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 868595006400 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 868595006401 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 868595006402 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 868595006403 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 868595006404 Walker A/P-loop; other site 868595006405 ATP binding site [chemical binding]; other site 868595006406 Q-loop/lid; other site 868595006407 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 868595006408 ABC transporter signature motif; other site 868595006409 Walker B; other site 868595006410 D-loop; other site 868595006411 H-loop/switch region; other site 868595006412 Arginine repressor [Transcription]; Region: ArgR; COG1438 868595006413 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 868595006414 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 868595006415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 868595006416 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 868595006417 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 868595006418 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 868595006419 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 868595006420 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 868595006421 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595006422 RNA binding surface [nucleotide binding]; other site 868595006423 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 868595006424 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 868595006425 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 868595006426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 868595006427 Walker A/P-loop; other site 868595006428 ATP binding site [chemical binding]; other site 868595006429 Q-loop/lid; other site 868595006430 ABC transporter signature motif; other site 868595006431 Walker B; other site 868595006432 D-loop; other site 868595006433 H-loop/switch region; other site 868595006434 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 868595006435 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 868595006436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 868595006437 Walker A/P-loop; other site 868595006438 ATP binding site [chemical binding]; other site 868595006439 Q-loop/lid; other site 868595006440 ABC transporter signature motif; other site 868595006441 Walker B; other site 868595006442 D-loop; other site 868595006443 H-loop/switch region; other site 868595006444 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 868595006445 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 868595006446 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 868595006447 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 868595006448 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 868595006449 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 868595006450 TPP-binding site; other site 868595006451 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 868595006452 PYR/PP interface [polypeptide binding]; other site 868595006453 dimer interface [polypeptide binding]; other site 868595006454 TPP binding site [chemical binding]; other site 868595006455 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 868595006456 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 868595006457 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 868595006458 substrate binding pocket [chemical binding]; other site 868595006459 chain length determination region; other site 868595006460 substrate-Mg2+ binding site; other site 868595006461 catalytic residues [active] 868595006462 aspartate-rich region 1; other site 868595006463 active site lid residues [active] 868595006464 aspartate-rich region 2; other site 868595006465 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 868595006466 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 868595006467 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 868595006468 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 868595006469 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 868595006470 homodimer interface [polypeptide binding]; other site 868595006471 NADP binding site [chemical binding]; other site 868595006472 substrate binding site [chemical binding]; other site 868595006473 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 868595006474 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 868595006475 generic binding surface II; other site 868595006476 generic binding surface I; other site 868595006477 putative oxidoreductase; Provisional; Region: PRK12831 868595006478 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 868595006479 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 868595006480 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 868595006481 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 868595006482 FAD binding pocket [chemical binding]; other site 868595006483 FAD binding motif [chemical binding]; other site 868595006484 phosphate binding motif [ion binding]; other site 868595006485 beta-alpha-beta structure motif; other site 868595006486 NAD binding pocket [chemical binding]; other site 868595006487 Iron coordination center [ion binding]; other site 868595006488 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 868595006489 putative RNA binding site [nucleotide binding]; other site 868595006490 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 868595006491 Asp23 family; Region: Asp23; pfam03780 868595006492 Asp23 family; Region: Asp23; pfam03780 868595006493 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 868595006494 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 868595006495 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 868595006496 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 868595006497 pyruvate carboxylase subunit B; Validated; Region: PRK09282 868595006498 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 868595006499 active site 868595006500 catalytic residues [active] 868595006501 metal binding site [ion binding]; metal-binding site 868595006502 homodimer binding site [polypeptide binding]; other site 868595006503 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 868595006504 carboxyltransferase (CT) interaction site; other site 868595006505 biotinylation site [posttranslational modification]; other site 868595006506 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 868595006507 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 868595006508 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 868595006509 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 868595006510 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 868595006511 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 868595006512 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 868595006513 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 868595006514 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 868595006515 Walker A motif; other site 868595006516 ATP binding site [chemical binding]; other site 868595006517 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595006518 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 868595006519 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 868595006520 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 868595006521 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 868595006522 active site residue [active] 868595006523 elongation factor P; Validated; Region: PRK00529 868595006524 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 868595006525 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 868595006526 RNA binding site [nucleotide binding]; other site 868595006527 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 868595006528 RNA binding site [nucleotide binding]; other site 868595006529 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 868595006530 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 868595006531 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 868595006532 active site 868595006533 Dehydroquinase class II; Region: DHquinase_II; pfam01220 868595006534 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 868595006535 trimer interface [polypeptide binding]; other site 868595006536 active site 868595006537 dimer interface [polypeptide binding]; other site 868595006538 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 868595006539 LrgB-like family; Region: LrgB; cl00596 868595006540 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 868595006541 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 868595006542 putative active site [active] 868595006543 putative metal binding site [ion binding]; other site 868595006544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595006545 Major Facilitator Superfamily; Region: MFS_1; pfam07690 868595006546 putative substrate translocation pore; other site 868595006547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595006548 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 868595006549 MarR family; Region: MarR; pfam01047 868595006550 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 868595006551 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 868595006552 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 868595006553 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 868595006554 hexamer interface [polypeptide binding]; other site 868595006555 ligand binding site [chemical binding]; other site 868595006556 putative active site [active] 868595006557 NAD(P) binding site [chemical binding]; other site 868595006558 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 868595006559 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 868595006560 Walker A/P-loop; other site 868595006561 ATP binding site [chemical binding]; other site 868595006562 Q-loop/lid; other site 868595006563 ABC transporter signature motif; other site 868595006564 Walker B; other site 868595006565 D-loop; other site 868595006566 H-loop/switch region; other site 868595006567 NIL domain; Region: NIL; pfam09383 868595006568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595006569 dimer interface [polypeptide binding]; other site 868595006570 conserved gate region; other site 868595006571 ABC-ATPase subunit interface; other site 868595006572 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 868595006573 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 868595006574 sporulation sigma factor SigK; Reviewed; Region: PRK05803 868595006575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595006576 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595006577 DNA binding residues [nucleotide binding] 868595006578 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 868595006579 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 868595006580 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 868595006581 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 868595006582 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 868595006583 Transcriptional regulators [Transcription]; Region: MarR; COG1846 868595006584 MarR family; Region: MarR; pfam01047 868595006585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595006586 Major Facilitator Superfamily; Region: MFS_1; pfam07690 868595006587 putative substrate translocation pore; other site 868595006588 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 868595006589 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595006590 Zn2+ binding site [ion binding]; other site 868595006591 Mg2+ binding site [ion binding]; other site 868595006592 Predicted permeases [General function prediction only]; Region: RarD; COG2962 868595006593 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 868595006594 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 868595006595 Transposase, Mutator family; Region: Transposase_mut; pfam00872 868595006596 MULE transposase domain; Region: MULE; pfam10551 868595006597 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 868595006598 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 868595006599 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 868595006600 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 868595006601 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 868595006602 5S rRNA interface [nucleotide binding]; other site 868595006603 CTC domain interface [polypeptide binding]; other site 868595006604 L16 interface [polypeptide binding]; other site 868595006605 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 868595006606 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 868595006607 active site 868595006608 substrate binding site [chemical binding]; other site 868595006609 metal binding site [ion binding]; metal-binding site 868595006610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 868595006611 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 868595006612 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 868595006613 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 868595006614 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 868595006615 active site 868595006616 Substrate binding site; other site 868595006617 Mg++ binding site; other site 868595006618 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 868595006619 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 868595006620 Domain of unknown function (DUF377); Region: DUF377; pfam04041 868595006621 active site 868595006622 DNA polymerase IV; Reviewed; Region: PRK03103 868595006623 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 868595006624 active site 868595006625 DNA binding site [nucleotide binding] 868595006626 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 868595006627 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 868595006628 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 868595006629 putative dimer interface [polypeptide binding]; other site 868595006630 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 868595006631 YabG peptidase U57; Region: Peptidase_U57; cl05250 868595006632 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 868595006633 Pilus assembly protein, PilO; Region: PilO; cl01234 868595006634 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 868595006635 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 868595006636 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 868595006637 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 868595006638 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 868595006639 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 868595006640 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 868595006641 type II secretion system protein I; Region: gspI; TIGR01707 868595006642 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 868595006643 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 868595006644 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 868595006645 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 868595006646 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 868595006647 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 868595006648 Walker A motif; other site 868595006649 ATP binding site [chemical binding]; other site 868595006650 Walker B motif; other site 868595006651 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 868595006652 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 868595006653 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 868595006654 Walker A motif; other site 868595006655 ATP binding site [chemical binding]; other site 868595006656 Walker B motif; other site 868595006657 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 868595006658 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 868595006659 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 868595006660 active site 868595006661 dimer interface [polypeptide binding]; other site 868595006662 metal binding site [ion binding]; metal-binding site 868595006663 shikimate kinase; Provisional; Region: PRK13947 868595006664 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 868595006665 ADP binding site [chemical binding]; other site 868595006666 magnesium binding site [ion binding]; other site 868595006667 putative shikimate binding site; other site 868595006668 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 868595006669 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 868595006670 Tetramer interface [polypeptide binding]; other site 868595006671 active site 868595006672 FMN-binding site [chemical binding]; other site 868595006673 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 868595006674 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 868595006675 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 868595006676 shikimate binding site; other site 868595006677 NAD(P) binding site [chemical binding]; other site 868595006678 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 868595006679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 868595006680 active site 868595006681 motif I; other site 868595006682 motif II; other site 868595006683 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595006684 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 868595006685 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 868595006686 catalytic residues [active] 868595006687 catalytic nucleophile [active] 868595006688 Recombinase; Region: Recombinase; pfam07508 868595006689 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 868595006690 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 868595006691 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595006692 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 868595006693 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 868595006694 IHF dimer interface [polypeptide binding]; other site 868595006695 IHF - DNA interface [nucleotide binding]; other site 868595006696 HEPN domain; Region: HEPN; pfam05168 868595006697 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 868595006698 active site 868595006699 NTP binding site [chemical binding]; other site 868595006700 metal binding triad [ion binding]; metal-binding site 868595006701 antibiotic binding site [chemical binding]; other site 868595006702 Replication-relaxation; Region: Replic_Relax; pfam13814 868595006703 Replication-relaxation; Region: Replic_Relax; pfam13814 868595006704 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 868595006705 AAA-like domain; Region: AAA_10; pfam12846 868595006706 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 868595006707 Helix-turn-helix domain; Region: HTH_36; pfam13730 868595006708 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 868595006709 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 868595006710 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595006711 metal binding site [ion binding]; metal-binding site 868595006712 active site 868595006713 I-site; other site 868595006714 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 868595006715 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595006716 Zn2+ binding site [ion binding]; other site 868595006717 Mg2+ binding site [ion binding]; other site 868595006718 Accessory gene regulator B; Region: AgrB; pfam04647 868595006719 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 868595006720 Helix-turn-helix domain; Region: HTH_38; pfam13936 868595006721 Integrase core domain; Region: rve; pfam00665 868595006722 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 868595006723 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 868595006724 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 868595006725 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 868595006726 catalytic residues [active] 868595006727 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 868595006728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 868595006729 non-specific DNA binding site [nucleotide binding]; other site 868595006730 salt bridge; other site 868595006731 sequence-specific DNA binding site [nucleotide binding]; other site 868595006732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 868595006733 non-specific DNA binding site [nucleotide binding]; other site 868595006734 salt bridge; other site 868595006735 sequence-specific DNA binding site [nucleotide binding]; other site 868595006736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 868595006737 non-specific DNA binding site [nucleotide binding]; other site 868595006738 salt bridge; other site 868595006739 sequence-specific DNA binding site [nucleotide binding]; other site 868595006740 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 868595006741 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 868595006742 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 868595006743 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 868595006744 Peptidase family U32; Region: Peptidase_U32; pfam01136 868595006745 YceG-like family; Region: YceG; pfam02618 868595006746 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 868595006747 dimerization interface [polypeptide binding]; other site 868595006748 Rrf2 family protein; Region: rrf2_super; TIGR00738 868595006749 Transcriptional regulator; Region: Rrf2; pfam02082 868595006750 FAD binding domain; Region: FAD_binding_4; pfam01565 868595006751 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 868595006752 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 868595006753 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 868595006754 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 868595006755 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 868595006756 Ligand binding site [chemical binding]; other site 868595006757 Electron transfer flavoprotein domain; Region: ETF; pfam01012 868595006758 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 868595006759 VanW like protein; Region: VanW; pfam04294 868595006760 G5 domain; Region: G5; pfam07501 868595006761 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 868595006762 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 868595006763 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 868595006764 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 868595006765 active site 868595006766 catalytic tetrad [active] 868595006767 hypothetical protein; Provisional; Region: PRK05473 868595006768 intracellular protease, PfpI family; Region: PfpI; TIGR01382 868595006769 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 868595006770 conserved cys residue [active] 868595006771 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 868595006772 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 868595006773 motif 1; other site 868595006774 active site 868595006775 motif 2; other site 868595006776 motif 3; other site 868595006777 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 868595006778 DHHA1 domain; Region: DHHA1; pfam02272 868595006779 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 868595006780 Domain of unknown function DUF20; Region: UPF0118; pfam01594 868595006781 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 868595006782 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 868595006783 Ligand Binding Site [chemical binding]; other site 868595006784 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 868595006785 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 868595006786 trimerization site [polypeptide binding]; other site 868595006787 active site 868595006788 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 868595006789 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 868595006790 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 868595006791 catalytic residue [active] 868595006792 Transcriptional regulator; Region: Rrf2; cl17282 868595006793 Rrf2 family protein; Region: rrf2_super; TIGR00738 868595006794 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 868595006795 catalytic residues [active] 868595006796 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 868595006797 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 868595006798 putative ATP binding site [chemical binding]; other site 868595006799 putative substrate interface [chemical binding]; other site 868595006800 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 868595006801 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595006802 dimerization interface [polypeptide binding]; other site 868595006803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595006804 dimer interface [polypeptide binding]; other site 868595006805 phosphorylation site [posttranslational modification] 868595006806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595006807 ATP binding site [chemical binding]; other site 868595006808 Mg2+ binding site [ion binding]; other site 868595006809 G-X-G motif; other site 868595006810 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595006811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595006812 active site 868595006813 phosphorylation site [posttranslational modification] 868595006814 intermolecular recognition site; other site 868595006815 dimerization interface [polypeptide binding]; other site 868595006816 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595006817 DNA binding site [nucleotide binding] 868595006818 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 868595006819 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 868595006820 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 868595006821 protein binding site [polypeptide binding]; other site 868595006822 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 868595006823 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 868595006824 dimer interface [polypeptide binding]; other site 868595006825 anticodon binding site; other site 868595006826 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 868595006827 homodimer interface [polypeptide binding]; other site 868595006828 motif 1; other site 868595006829 active site 868595006830 motif 2; other site 868595006831 GAD domain; Region: GAD; pfam02938 868595006832 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 868595006833 motif 3; other site 868595006834 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 868595006835 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 868595006836 dimer interface [polypeptide binding]; other site 868595006837 motif 1; other site 868595006838 active site 868595006839 motif 2; other site 868595006840 motif 3; other site 868595006841 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 868595006842 anticodon binding site; other site 868595006843 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 868595006844 GAF domain; Region: GAF_3; pfam13492 868595006845 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 868595006846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595006847 metal binding site [ion binding]; metal-binding site 868595006848 active site 868595006849 I-site; other site 868595006850 Sensory domain found in PocR; Region: PocR; pfam10114 868595006851 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 868595006852 Walker B motif; other site 868595006853 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 868595006854 KaiC; Region: KaiC; pfam06745 868595006855 ATP binding site [chemical binding]; other site 868595006856 Walker B motif; other site 868595006857 D-allose kinase; Provisional; Region: PRK09698 868595006858 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595006859 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595006860 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595006861 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 868595006862 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 868595006863 GAF domain; Region: GAF; cl17456 868595006864 Histidine kinase; Region: His_kinase; pfam06580 868595006865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595006866 ATP binding site [chemical binding]; other site 868595006867 Mg2+ binding site [ion binding]; other site 868595006868 G-X-G motif; other site 868595006869 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 868595006870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595006871 NAD(P) binding site [chemical binding]; other site 868595006872 active site 868595006873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 868595006874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 868595006875 Predicted membrane protein [Function unknown]; Region: COG1511 868595006876 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 868595006877 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 868595006878 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 868595006879 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 868595006880 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 868595006881 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 868595006882 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 868595006883 active site 868595006884 metal binding site [ion binding]; metal-binding site 868595006885 homotetramer interface [polypeptide binding]; other site 868595006886 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 868595006887 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 868595006888 putative active site [active] 868595006889 dimerization interface [polypeptide binding]; other site 868595006890 putative tRNAtyr binding site [nucleotide binding]; other site 868595006891 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595006892 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595006893 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 868595006894 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 868595006895 DNA binding residues [nucleotide binding] 868595006896 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 868595006897 catalytic residues [active] 868595006898 catalytic nucleophile [active] 868595006899 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 868595006900 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595006901 Zn2+ binding site [ion binding]; other site 868595006902 Mg2+ binding site [ion binding]; other site 868595006903 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 868595006904 synthetase active site [active] 868595006905 NTP binding site [chemical binding]; other site 868595006906 metal binding site [ion binding]; metal-binding site 868595006907 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 868595006908 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 868595006909 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595006910 active site 868595006911 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 868595006912 DHH family; Region: DHH; pfam01368 868595006913 DHHA1 domain; Region: DHHA1; pfam02272 868595006914 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 868595006915 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 868595006916 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 868595006917 Walker A/P-loop; other site 868595006918 ATP binding site [chemical binding]; other site 868595006919 Q-loop/lid; other site 868595006920 ABC transporter signature motif; other site 868595006921 Walker B; other site 868595006922 D-loop; other site 868595006923 H-loop/switch region; other site 868595006924 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 868595006925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 868595006926 dimer interface [polypeptide binding]; other site 868595006927 conserved gate region; other site 868595006928 putative PBP binding loops; other site 868595006929 ABC-ATPase subunit interface; other site 868595006930 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 868595006931 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 868595006932 substrate binding pocket [chemical binding]; other site 868595006933 membrane-bound complex binding site; other site 868595006934 hinge residues; other site 868595006935 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 868595006936 EamA-like transporter family; Region: EamA; pfam00892 868595006937 EamA-like transporter family; Region: EamA; pfam00892 868595006938 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 868595006939 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 868595006940 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 868595006941 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 868595006942 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 868595006943 tetramer interface [polypeptide binding]; other site 868595006944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595006945 catalytic residue [active] 868595006946 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 868595006947 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 868595006948 tetramer interface [polypeptide binding]; other site 868595006949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595006950 catalytic residue [active] 868595006951 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 868595006952 lipoyl attachment site [posttranslational modification]; other site 868595006953 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 868595006954 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 868595006955 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 868595006956 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 868595006957 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 868595006958 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 868595006959 HIGH motif; other site 868595006960 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 868595006961 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 868595006962 active site 868595006963 KMSKS motif; other site 868595006964 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 868595006965 tRNA binding surface [nucleotide binding]; other site 868595006966 anticodon binding site; other site 868595006967 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 868595006968 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 868595006969 DivIVA protein; Region: DivIVA; pfam05103 868595006970 DivIVA domain; Region: DivI1A_domain; TIGR03544 868595006971 V-type ATP synthase subunit E; Provisional; Region: PRK01558 868595006972 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 868595006973 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 868595006974 RNA binding surface [nucleotide binding]; other site 868595006975 YGGT family; Region: YGGT; pfam02325 868595006976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 868595006977 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 868595006978 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 868595006979 catalytic residue [active] 868595006980 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 868595006981 lipoyl-biotinyl attachment site [posttranslational modification]; other site 868595006982 HlyD family secretion protein; Region: HlyD_2; pfam12700 868595006983 putative membrane fusion protein; Region: TIGR02828 868595006984 Recombinase; Region: Recombinase; pfam07508 868595006985 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 868595006986 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 868595006987 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 868595006988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 868595006989 Integrase core domain; Region: rve; pfam00665 868595006990 Integrase core domain; Region: rve_3; pfam13683 868595006991 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 868595006992 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 868595006993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595006994 Walker A motif; other site 868595006995 ATP binding site [chemical binding]; other site 868595006996 Walker B motif; other site 868595006997 arginine finger; other site 868595006998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 868595006999 non-specific DNA binding site [nucleotide binding]; other site 868595007000 salt bridge; other site 868595007001 sequence-specific DNA binding site [nucleotide binding]; other site 868595007002 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 868595007003 HsdM N-terminal domain; Region: HsdM_N; pfam12161 868595007004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595007005 S-adenosylmethionine binding site [chemical binding]; other site 868595007006 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 868595007007 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 868595007008 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 868595007009 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 868595007010 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 868595007011 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595007012 ATP binding site [chemical binding]; other site 868595007013 putative Mg++ binding site [ion binding]; other site 868595007014 Abortive infection C-terminus; Region: Abi_C; pfam14355 868595007015 HAMP domain; Region: HAMP; pfam00672 868595007016 dimerization interface [polypeptide binding]; other site 868595007017 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 868595007018 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595007019 putative active site [active] 868595007020 heme pocket [chemical binding]; other site 868595007021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 868595007022 dimer interface [polypeptide binding]; other site 868595007023 phosphorylation site [posttranslational modification] 868595007024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595007025 ATP binding site [chemical binding]; other site 868595007026 Mg2+ binding site [ion binding]; other site 868595007027 G-X-G motif; other site 868595007028 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595007029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595007030 active site 868595007031 phosphorylation site [posttranslational modification] 868595007032 intermolecular recognition site; other site 868595007033 dimerization interface [polypeptide binding]; other site 868595007034 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595007035 DNA binding site [nucleotide binding] 868595007036 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 868595007037 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 868595007038 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 868595007039 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 868595007040 Beta-Casp domain; Region: Beta-Casp; smart01027 868595007041 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 868595007042 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 868595007043 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 868595007044 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 868595007045 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 868595007046 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 868595007047 ResB-like family; Region: ResB; pfam05140 868595007048 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 868595007049 Cytochrome c552; Region: Cytochrom_C552; pfam02335 868595007050 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 868595007051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595007052 S-adenosylmethionine binding site [chemical binding]; other site 868595007053 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 868595007054 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 868595007055 ligand binding site [chemical binding]; other site 868595007056 flexible hinge region; other site 868595007057 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 868595007058 putative switch regulator; other site 868595007059 non-specific DNA interactions [nucleotide binding]; other site 868595007060 DNA binding site [nucleotide binding] 868595007061 sequence specific DNA binding site [nucleotide binding]; other site 868595007062 putative cAMP binding site [chemical binding]; other site 868595007063 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 868595007064 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 868595007065 Predicted integral membrane protein [Function unknown]; Region: COG5615 868595007066 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 868595007067 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 868595007068 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595007069 FeS/SAM binding site; other site 868595007070 ATP cone domain; Region: ATP-cone; pfam03477 868595007071 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 868595007072 Class III ribonucleotide reductase; Region: RNR_III; cd01675 868595007073 effector binding site; other site 868595007074 active site 868595007075 Zn binding site [ion binding]; other site 868595007076 glycine loop; other site 868595007077 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 868595007078 ATP cone domain; Region: ATP-cone; pfam03477 868595007079 spore photoproduct lyase; Region: photo_TT_lyase; TIGR04070 868595007080 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 868595007081 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 868595007082 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 868595007083 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 868595007084 Cysteine-rich domain; Region: CCG; pfam02754 868595007085 Cysteine-rich domain; Region: CCG; pfam02754 868595007086 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 868595007087 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 868595007088 sporulation sigma factor SigG; Reviewed; Region: PRK08215 868595007089 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595007090 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 868595007091 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595007092 DNA binding residues [nucleotide binding] 868595007093 sporulation sigma factor SigE; Reviewed; Region: PRK08301 868595007094 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595007095 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595007096 DNA binding residues [nucleotide binding] 868595007097 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 868595007098 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 868595007099 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 868595007100 cell division protein FtsZ; Validated; Region: PRK09330 868595007101 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 868595007102 nucleotide binding site [chemical binding]; other site 868595007103 SulA interaction site; other site 868595007104 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 868595007105 nucleotide binding site [chemical binding]; other site 868595007106 Cell division protein FtsA; Region: FtsA; pfam14450 868595007107 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 868595007108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 868595007109 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 868595007110 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 868595007111 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 868595007112 Cell division protein FtsQ; Region: FtsQ; pfam03799 868595007113 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 868595007114 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 868595007115 hinge; other site 868595007116 active site 868595007117 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 868595007118 FAD binding domain; Region: FAD_binding_4; pfam01565 868595007119 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 868595007120 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 868595007121 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 868595007122 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 868595007123 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 868595007124 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 868595007125 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 868595007126 active site 868595007127 homodimer interface [polypeptide binding]; other site 868595007128 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 868595007129 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 868595007130 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 868595007131 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 868595007132 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 868595007133 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 868595007134 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 868595007135 Mg++ binding site [ion binding]; other site 868595007136 putative catalytic motif [active] 868595007137 putative substrate binding site [chemical binding]; other site 868595007138 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 868595007139 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 868595007140 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 868595007141 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 868595007142 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 868595007143 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 868595007144 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 868595007145 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 868595007146 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 868595007147 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 868595007148 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 868595007149 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 868595007150 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 868595007151 Cell division protein FtsL; Region: FtsL; cl11433 868595007152 MraW methylase family; Region: Methyltransf_5; pfam01795 868595007153 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 868595007154 cell division protein MraZ; Reviewed; Region: PRK00326 868595007155 MraZ protein; Region: MraZ; pfam02381 868595007156 MraZ protein; Region: MraZ; pfam02381 868595007157 histidinol-phosphatase; Provisional; Region: PRK07328 868595007158 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 868595007159 active site 868595007160 dimer interface [polypeptide binding]; other site 868595007161 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 868595007162 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 868595007163 active site 868595007164 nucleophile elbow; other site 868595007165 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 868595007166 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 868595007167 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 868595007168 putative active site [active] 868595007169 heme pocket [chemical binding]; other site 868595007170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595007171 Walker A motif; other site 868595007172 ATP binding site [chemical binding]; other site 868595007173 Walker B motif; other site 868595007174 arginine finger; other site 868595007175 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 868595007176 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 868595007177 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 868595007178 G1 box; other site 868595007179 GTP/Mg2+ binding site [chemical binding]; other site 868595007180 Switch I region; other site 868595007181 G2 box; other site 868595007182 G3 box; other site 868595007183 Switch II region; other site 868595007184 G4 box; other site 868595007185 G5 box; other site 868595007186 Nucleoside recognition; Region: Gate; pfam07670 868595007187 Nucleoside recognition; Region: Gate; pfam07670 868595007188 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 868595007189 metal binding site 2 [ion binding]; metal-binding site 868595007190 putative DNA binding helix; other site 868595007191 metal binding site 1 [ion binding]; metal-binding site 868595007192 dimer interface [polypeptide binding]; other site 868595007193 structural Zn2+ binding site [ion binding]; other site 868595007194 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 868595007195 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 868595007196 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 868595007197 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 868595007198 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 868595007199 G1 box; other site 868595007200 GTP/Mg2+ binding site [chemical binding]; other site 868595007201 Switch I region; other site 868595007202 G2 box; other site 868595007203 G3 box; other site 868595007204 Switch II region; other site 868595007205 G4 box; other site 868595007206 G5 box; other site 868595007207 Nucleoside recognition; Region: Gate; pfam07670 868595007208 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 868595007209 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 868595007210 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 868595007211 active site 868595007212 Divergent PAP2 family; Region: DUF212; pfam02681 868595007213 Major Facilitator Superfamily; Region: MFS_1; pfam07690 868595007214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595007215 putative substrate translocation pore; other site 868595007216 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 868595007217 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 868595007218 NodB motif; other site 868595007219 putative active site [active] 868595007220 putative catalytic site [active] 868595007221 putative Zn binding site [ion binding]; other site 868595007222 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 868595007223 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 868595007224 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 868595007225 protein binding site [polypeptide binding]; other site 868595007226 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 868595007227 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 868595007228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 868595007229 Transposase; Region: DEDD_Tnp_IS110; pfam01548 868595007230 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 868595007231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 868595007232 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 868595007233 helix-hairpin-helix signature motif; other site 868595007234 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 868595007235 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 868595007236 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595007237 Zn2+ binding site [ion binding]; other site 868595007238 Mg2+ binding site [ion binding]; other site 868595007239 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 868595007240 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 868595007241 NodB motif; other site 868595007242 active site 868595007243 catalytic site [active] 868595007244 metal binding site [ion binding]; metal-binding site 868595007245 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 868595007246 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 868595007247 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 868595007248 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 868595007249 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 868595007250 4Fe-4S binding domain; Region: Fer4; cl02805 868595007251 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 868595007252 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 868595007253 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 868595007254 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595007255 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 868595007256 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 868595007257 ATP-sulfurylase; Region: ATPS; cd00517 868595007258 active site 868595007259 HXXH motif; other site 868595007260 flexible loop; other site 868595007261 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 868595007262 Cysteine-rich domain; Region: CCG; pfam02754 868595007263 Cysteine-rich domain; Region: CCG; pfam02754 868595007264 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 868595007265 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 868595007266 Flagellin N-methylase; Region: FliB; pfam03692 868595007267 Protein of unknown function (DUF964); Region: DUF964; pfam06133 868595007268 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595007269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595007270 active site 868595007271 phosphorylation site [posttranslational modification] 868595007272 intermolecular recognition site; other site 868595007273 dimerization interface [polypeptide binding]; other site 868595007274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595007275 DNA binding site [nucleotide binding] 868595007276 EamA-like transporter family; Region: EamA; cl17759 868595007277 PilZ domain; Region: PilZ; pfam07238 868595007278 VanW like protein; Region: VanW; pfam04294 868595007279 G5 domain; Region: G5; pfam07501 868595007280 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 868595007281 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 868595007282 putative FMN binding site [chemical binding]; other site 868595007283 DEAD-like helicases superfamily; Region: DEXDc; smart00487 868595007284 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595007285 ATP binding site [chemical binding]; other site 868595007286 putative Mg++ binding site [ion binding]; other site 868595007287 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595007288 ATP-binding site [chemical binding]; other site 868595007289 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 868595007290 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 868595007291 S-layer homology domain; Region: SLH; pfam00395 868595007292 S-layer homology domain; Region: SLH; pfam00395 868595007293 Predicted permease; Region: DUF318; cl17795 868595007294 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 868595007295 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 868595007296 catalytic residues [active] 868595007297 4Fe-4S binding domain; Region: Fer4_5; pfam12801 868595007298 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 868595007299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595007300 S-adenosylmethionine binding site [chemical binding]; other site 868595007301 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 868595007302 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 868595007303 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 868595007304 Predicted membrane protein [Function unknown]; Region: COG3462 868595007305 Short C-terminal domain; Region: SHOCT; pfam09851 868595007306 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 868595007307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595007308 active site 868595007309 phosphorylation site [posttranslational modification] 868595007310 intermolecular recognition site; other site 868595007311 dimerization interface [polypeptide binding]; other site 868595007312 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 868595007313 DNA binding site [nucleotide binding] 868595007314 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 868595007315 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 868595007316 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595007317 metal binding site [ion binding]; metal-binding site 868595007318 active site 868595007319 I-site; other site 868595007320 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 868595007321 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 868595007322 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 868595007323 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 868595007324 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 868595007325 S-layer homology domain; Region: SLH; pfam00395 868595007326 S-layer homology domain; Region: SLH; pfam00395 868595007327 S-layer homology domain; Region: SLH; pfam00395 868595007328 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 868595007329 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 868595007330 trimer interface [polypeptide binding]; other site 868595007331 active site 868595007332 4Fe-4S binding domain; Region: Fer4_5; pfam12801 868595007333 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 868595007334 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 868595007335 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595007336 agmatinase; Region: agmatinase; TIGR01230 868595007337 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 868595007338 putative active site [active] 868595007339 Mn binding site [ion binding]; other site 868595007340 spermidine synthase; Provisional; Region: PRK00811 868595007341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595007342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595007343 S-adenosylmethionine binding site [chemical binding]; other site 868595007344 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 868595007345 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 868595007346 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 868595007347 Metal-binding active site; metal-binding site 868595007348 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 868595007349 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 868595007350 peptide binding site [polypeptide binding]; other site 868595007351 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 868595007352 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 868595007353 trimer interface [polypeptide binding]; other site 868595007354 putative metal binding site [ion binding]; other site 868595007355 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 868595007356 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 868595007357 homotetramer interface [polypeptide binding]; other site 868595007358 FMN binding site [chemical binding]; other site 868595007359 homodimer contacts [polypeptide binding]; other site 868595007360 putative active site [active] 868595007361 putative substrate binding site [chemical binding]; other site 868595007362 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 868595007363 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 868595007364 G1 box; other site 868595007365 putative GEF interaction site [polypeptide binding]; other site 868595007366 GTP/Mg2+ binding site [chemical binding]; other site 868595007367 Switch I region; other site 868595007368 G2 box; other site 868595007369 G3 box; other site 868595007370 Switch II region; other site 868595007371 G4 box; other site 868595007372 G5 box; other site 868595007373 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 868595007374 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 868595007375 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 868595007376 amino acid carrier protein; Region: agcS; TIGR00835 868595007377 Inner membrane protein import complex subunit Tim54; Region: Tim54; pfam11711 868595007378 Predicted membrane protein [Function unknown]; Region: COG1950 868595007379 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 868595007380 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 868595007381 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 868595007382 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 868595007383 transposase; Provisional; Region: PRK06526 868595007384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595007385 Walker A motif; other site 868595007386 ATP binding site [chemical binding]; other site 868595007387 Walker B motif; other site 868595007388 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 868595007389 Winged helix-turn helix; Region: HTH_29; pfam13551 868595007390 DNA binding residues [nucleotide binding] 868595007391 Integrase core domain; Region: rve; pfam00665 868595007392 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595007393 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 868595007394 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 868595007395 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 868595007396 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 868595007397 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 868595007398 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 868595007399 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 868595007400 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 868595007401 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 868595007402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595007403 putative substrate translocation pore; other site 868595007404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595007405 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 868595007406 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 868595007407 HlyD family secretion protein; Region: HlyD_3; pfam13437 868595007408 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 868595007409 HlyD family secretion protein; Region: HlyD_3; pfam13437 868595007410 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595007411 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 868595007412 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 868595007413 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 868595007414 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 868595007415 metal binding site [ion binding]; metal-binding site 868595007416 RDD family; Region: RDD; pfam06271 868595007417 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 868595007418 Cysteine-rich domain; Region: CCG; pfam02754 868595007419 Cysteine-rich domain; Region: CCG; pfam02754 868595007420 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 868595007421 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 868595007422 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 868595007423 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 868595007424 Protein of unknown function (DUF327); Region: DUF327; pfam03885 868595007425 Transposase, Mutator family; Region: Transposase_mut; pfam00872 868595007426 MULE transposase domain; Region: MULE; pfam10551 868595007427 Carbonic anhydrase; Region: Pro_CA; smart00947 868595007428 active site clefts [active] 868595007429 zinc binding site [ion binding]; other site 868595007430 dimer interface [polypeptide binding]; other site 868595007431 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 868595007432 FOG: CBS domain [General function prediction only]; Region: COG0517 868595007433 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 868595007434 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 868595007435 amino acid transporter; Region: 2A0306; TIGR00909 868595007436 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 868595007437 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 868595007438 putative homodimer interface [polypeptide binding]; other site 868595007439 putative active site pocket [active] 868595007440 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 868595007441 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 868595007442 EamA-like transporter family; Region: EamA; pfam00892 868595007443 EamA-like transporter family; Region: EamA; pfam00892 868595007444 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 868595007445 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595007446 ATP binding site [chemical binding]; other site 868595007447 putative Mg++ binding site [ion binding]; other site 868595007448 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595007449 nucleotide binding region [chemical binding]; other site 868595007450 ATP-binding site [chemical binding]; other site 868595007451 RQC domain; Region: RQC; pfam09382 868595007452 HRDC domain; Region: HRDC; pfam00570 868595007453 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 868595007454 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 868595007455 dimerization interface [polypeptide binding]; other site 868595007456 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 868595007457 dimer interface [polypeptide binding]; other site 868595007458 putative CheW interface [polypeptide binding]; other site 868595007459 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 868595007460 dinuclear metal binding motif [ion binding]; other site 868595007461 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 868595007462 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 868595007463 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 868595007464 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 868595007465 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 868595007466 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 868595007467 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 868595007468 active site 868595007469 multimer interface [polypeptide binding]; other site 868595007470 threonine synthase; Validated; Region: PRK08197 868595007471 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 868595007472 homodimer interface [polypeptide binding]; other site 868595007473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595007474 catalytic residue [active] 868595007475 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 868595007476 homotrimer interaction site [polypeptide binding]; other site 868595007477 putative active site [active] 868595007478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 868595007479 YheO-like PAS domain; Region: PAS_6; pfam08348 868595007480 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 868595007481 DNA-binding interface [nucleotide binding]; DNA binding site 868595007482 TIGR02677 family protein; Region: TIGR02677 868595007483 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 868595007484 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 868595007485 TIGR02680 family protein; Region: TIGR02680 868595007486 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 868595007487 TIGR02679 family protein; Region: TIGR02679 868595007488 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 868595007489 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 868595007490 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 868595007491 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 868595007492 Uncharacterized conserved protein [Function unknown]; Region: COG3535 868595007493 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 868595007494 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 868595007495 Na binding site [ion binding]; other site 868595007496 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 868595007497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595007498 Walker A motif; other site 868595007499 ATP binding site [chemical binding]; other site 868595007500 Walker B motif; other site 868595007501 arginine finger; other site 868595007502 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 868595007503 Protein of unknown function (DUF917); Region: DUF917; pfam06032 868595007504 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 868595007505 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 868595007506 SmpB-tmRNA interface; other site 868595007507 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595007508 Zn2+ binding site [ion binding]; other site 868595007509 Mg2+ binding site [ion binding]; other site 868595007510 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 868595007511 CoenzymeA binding site [chemical binding]; other site 868595007512 subunit interaction site [polypeptide binding]; other site 868595007513 PHB binding site; other site 868595007514 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 868595007515 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 868595007516 enolase; Provisional; Region: eno; PRK00077 868595007517 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 868595007518 dimer interface [polypeptide binding]; other site 868595007519 metal binding site [ion binding]; metal-binding site 868595007520 substrate binding pocket [chemical binding]; other site 868595007521 phosphoglyceromutase; Provisional; Region: PRK05434 868595007522 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 868595007523 triosephosphate isomerase; Provisional; Region: PRK14565 868595007524 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 868595007525 substrate binding site [chemical binding]; other site 868595007526 dimer interface [polypeptide binding]; other site 868595007527 catalytic triad [active] 868595007528 Phosphoglycerate kinase; Region: PGK; pfam00162 868595007529 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 868595007530 substrate binding site [chemical binding]; other site 868595007531 hinge regions; other site 868595007532 ADP binding site [chemical binding]; other site 868595007533 catalytic site [active] 868595007534 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 868595007535 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 868595007536 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 868595007537 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 868595007538 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 868595007539 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 868595007540 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 868595007541 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 868595007542 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 868595007543 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 868595007544 trimer interface [polypeptide binding]; other site 868595007545 CoA binding site [chemical binding]; other site 868595007546 active site 868595007547 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 868595007548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 868595007549 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 868595007550 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 868595007551 putative active site [active] 868595007552 putative metal binding site [ion binding]; other site 868595007553 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 868595007554 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 868595007555 phosphate binding site [ion binding]; other site 868595007556 putative substrate binding pocket [chemical binding]; other site 868595007557 dimer interface [polypeptide binding]; other site 868595007558 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 868595007559 AAA domain; Region: AAA_33; pfam13671 868595007560 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 868595007561 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 868595007562 nucleotide binding site [chemical binding]; other site 868595007563 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 868595007564 regulatory protein interface [polypeptide binding]; other site 868595007565 regulatory phosphorylation site [posttranslational modification]; other site 868595007566 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 868595007567 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 868595007568 motif II; other site 868595007569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 868595007570 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 868595007571 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 868595007572 GIY-YIG motif/motif A; other site 868595007573 active site 868595007574 catalytic site [active] 868595007575 putative DNA binding site [nucleotide binding]; other site 868595007576 metal binding site [ion binding]; metal-binding site 868595007577 UvrB/uvrC motif; Region: UVR; pfam02151 868595007578 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 868595007579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 868595007580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 868595007581 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 868595007582 HlyD family secretion protein; Region: HlyD_3; pfam13437 868595007583 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 868595007584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 868595007585 Walker A/P-loop; other site 868595007586 ATP binding site [chemical binding]; other site 868595007587 Q-loop/lid; other site 868595007588 ABC transporter signature motif; other site 868595007589 Walker B; other site 868595007590 D-loop; other site 868595007591 H-loop/switch region; other site 868595007592 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 868595007593 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 868595007594 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 868595007595 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 868595007596 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 868595007597 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 868595007598 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 868595007599 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 868595007600 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 868595007601 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 868595007602 excinuclease ABC subunit B; Provisional; Region: PRK05298 868595007603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 868595007604 ATP binding site [chemical binding]; other site 868595007605 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 868595007606 nucleotide binding region [chemical binding]; other site 868595007607 ATP-binding site [chemical binding]; other site 868595007608 Ultra-violet resistance protein B; Region: UvrB; pfam12344 868595007609 UvrB/uvrC motif; Region: UVR; pfam02151 868595007610 Rubredoxin [Energy production and conversion]; Region: COG1773 868595007611 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 868595007612 iron binding site [ion binding]; other site 868595007613 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 868595007614 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 868595007615 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 868595007616 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 868595007617 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 868595007618 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 868595007619 Fe-S cluster binding site [ion binding]; other site 868595007620 active site 868595007621 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 868595007622 Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133 868595007623 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 868595007624 protein binding site [polypeptide binding]; other site 868595007625 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 868595007626 C-terminal peptidase (prc); Region: prc; TIGR00225 868595007627 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 868595007628 protein binding site [polypeptide binding]; other site 868595007629 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 868595007630 Catalytic dyad [active] 868595007631 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 868595007632 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 868595007633 Peptidase family M23; Region: Peptidase_M23; pfam01551 868595007634 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 868595007635 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 868595007636 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 868595007637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 868595007638 Walker A/P-loop; other site 868595007639 ATP binding site [chemical binding]; other site 868595007640 Q-loop/lid; other site 868595007641 ABC transporter signature motif; other site 868595007642 Walker B; other site 868595007643 D-loop; other site 868595007644 H-loop/switch region; other site 868595007645 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 868595007646 Acyltransferase family; Region: Acyl_transf_3; pfam01757 868595007647 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 868595007648 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 868595007649 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 868595007650 PYR/PP interface [polypeptide binding]; other site 868595007651 dimer interface [polypeptide binding]; other site 868595007652 TPP binding site [chemical binding]; other site 868595007653 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 868595007654 transketolase; Reviewed; Region: PRK05899 868595007655 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 868595007656 TPP-binding site [chemical binding]; other site 868595007657 dimer interface [polypeptide binding]; other site 868595007658 Uncharacterized conserved protein [Function unknown]; Region: COG1284 868595007659 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 868595007660 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 868595007661 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 868595007662 peptide chain release factor 2; Validated; Region: prfB; PRK00578 868595007663 This domain is found in peptide chain release factors; Region: PCRF; smart00937 868595007664 RF-1 domain; Region: RF-1; pfam00472 868595007665 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 868595007666 DEAD/DEAH box helicase; Region: DEAD; pfam00270 868595007667 ATP binding site [chemical binding]; other site 868595007668 putative Mg++ binding site [ion binding]; other site 868595007669 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 868595007670 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 868595007671 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 868595007672 tetramer interface [polypeptide binding]; other site 868595007673 catalytic Zn binding site [ion binding]; other site 868595007674 NADP binding site [chemical binding]; other site 868595007675 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 868595007676 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 868595007677 catalytic loop [active] 868595007678 iron binding site [ion binding]; other site 868595007679 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 868595007680 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 868595007681 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 868595007682 active site 868595007683 NAD binding site [chemical binding]; other site 868595007684 metal binding site [ion binding]; metal-binding site 868595007685 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 868595007686 30S subunit binding site; other site 868595007687 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 868595007688 DNA-binding site [nucleotide binding]; DNA binding site 868595007689 RNA-binding motif; other site 868595007690 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 868595007691 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595007692 active site 868595007693 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 868595007694 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 868595007695 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 868595007696 GAF domain; Region: GAF_3; pfam13492 868595007697 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 868595007698 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 868595007699 metal binding site [ion binding]; metal-binding site 868595007700 active site 868595007701 I-site; other site 868595007702 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 868595007703 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 868595007704 S-adenosylmethionine synthetase; Validated; Region: PRK05250 868595007705 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 868595007706 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 868595007707 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 868595007708 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 868595007709 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 868595007710 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 868595007711 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 868595007712 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 868595007713 active site 868595007714 catalytic triad [active] 868595007715 S-layer homology domain; Region: SLH; pfam00395 868595007716 S-layer homology domain; Region: SLH; pfam00395 868595007717 S-layer homology domain; Region: SLH; pfam00395 868595007718 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 868595007719 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 868595007720 active site 868595007721 substrate binding site [chemical binding]; other site 868595007722 metal binding site [ion binding]; metal-binding site 868595007723 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 868595007724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 868595007725 NAD(P) binding site [chemical binding]; other site 868595007726 active site 868595007727 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 868595007728 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 868595007729 active site 868595007730 tetramer interface; other site 868595007731 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 868595007732 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 868595007733 Mg++ binding site [ion binding]; other site 868595007734 putative catalytic motif [active] 868595007735 substrate binding site [chemical binding]; other site 868595007736 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 868595007737 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 868595007738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 868595007739 Walker A/P-loop; other site 868595007740 ATP binding site [chemical binding]; other site 868595007741 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 868595007742 Q-loop/lid; other site 868595007743 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595007744 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 868595007745 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 868595007746 Transcriptional regulator [Transcription]; Region: LytR; COG1316 868595007747 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 868595007748 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 868595007749 Uncharacterized conserved protein [Function unknown]; Region: COG5464 868595007750 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 868595007751 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 868595007752 putative active site [active] 868595007753 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 868595007754 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 868595007755 DNA binding residues [nucleotide binding] 868595007756 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 868595007757 catalytic residues [active] 868595007758 catalytic nucleophile [active] 868595007759 Nitrogen regulatory protein P-II; Region: P-II; cl00412 868595007760 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 868595007761 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 868595007762 catalytic triad [active] 868595007763 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595007764 Transposase domain (DUF772); Region: DUF772; pfam05598 868595007765 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 868595007766 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 868595007767 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 868595007768 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 868595007769 active site 868595007770 NTP binding site [chemical binding]; other site 868595007771 metal binding triad [ion binding]; metal-binding site 868595007772 antibiotic binding site [chemical binding]; other site 868595007773 Protein of unknown function DUF86; Region: DUF86; cl01031 868595007774 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 868595007775 active site 868595007776 catalytic triad [active] 868595007777 oxyanion hole [active] 868595007778 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595007779 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 868595007780 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 868595007781 active site 868595007782 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 868595007783 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 868595007784 putative homodimer interface [polypeptide binding]; other site 868595007785 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 868595007786 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 868595007787 Methyltransferase domain; Region: Methyltransf_31; pfam13847 868595007788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595007789 S-adenosylmethionine binding site [chemical binding]; other site 868595007790 TraB family; Region: TraB; cl12050 868595007791 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 868595007792 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 868595007793 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 868595007794 Walker A/P-loop; other site 868595007795 ATP binding site [chemical binding]; other site 868595007796 Q-loop/lid; other site 868595007797 ABC transporter signature motif; other site 868595007798 Walker B; other site 868595007799 D-loop; other site 868595007800 H-loop/switch region; other site 868595007801 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 868595007802 putative carbohydrate binding site [chemical binding]; other site 868595007803 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 868595007804 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 868595007805 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 868595007806 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 868595007807 NAD binding site [chemical binding]; other site 868595007808 substrate binding site [chemical binding]; other site 868595007809 homodimer interface [polypeptide binding]; other site 868595007810 active site 868595007811 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 868595007812 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 868595007813 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 868595007814 substrate binding site; other site 868595007815 tetramer interface; other site 868595007816 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 868595007817 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 868595007818 NADP binding site [chemical binding]; other site 868595007819 active site 868595007820 putative substrate binding site [chemical binding]; other site 868595007821 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 868595007822 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 868595007823 active site 868595007824 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 868595007825 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 868595007826 Bacterial sugar transferase; Region: Bac_transf; pfam02397 868595007827 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 868595007828 O-Antigen ligase; Region: Wzy_C; pfam04932 868595007829 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595007830 binding surface 868595007831 Tetratricopeptide repeat; Region: TPR_16; pfam13432 868595007832 TPR motif; other site 868595007833 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 868595007834 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595007835 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 868595007836 PQQ-like domain; Region: PQQ_2; pfam13360 868595007837 rod shape-determining protein Mbl; Provisional; Region: PRK13928 868595007838 MreB and similar proteins; Region: MreB_like; cd10225 868595007839 nucleotide binding site [chemical binding]; other site 868595007840 Mg binding site [ion binding]; other site 868595007841 putative protofilament interaction site [polypeptide binding]; other site 868595007842 RodZ interaction site [polypeptide binding]; other site 868595007843 Stage III sporulation protein D; Region: SpoIIID; pfam12116 868595007844 Peptidase family M23; Region: Peptidase_M23; pfam01551 868595007845 Stage II sporulation protein; Region: SpoIID; pfam08486 868595007846 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 868595007847 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 868595007848 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 868595007849 hinge; other site 868595007850 active site 868595007851 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 868595007852 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 868595007853 gamma subunit interface [polypeptide binding]; other site 868595007854 epsilon subunit interface [polypeptide binding]; other site 868595007855 LBP interface [polypeptide binding]; other site 868595007856 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 868595007857 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 868595007858 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 868595007859 alpha subunit interaction interface [polypeptide binding]; other site 868595007860 Walker A motif; other site 868595007861 ATP binding site [chemical binding]; other site 868595007862 Walker B motif; other site 868595007863 inhibitor binding site; inhibition site 868595007864 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 868595007865 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 868595007866 core domain interface [polypeptide binding]; other site 868595007867 delta subunit interface [polypeptide binding]; other site 868595007868 epsilon subunit interface [polypeptide binding]; other site 868595007869 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 868595007870 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 868595007871 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 868595007872 beta subunit interaction interface [polypeptide binding]; other site 868595007873 Walker A motif; other site 868595007874 ATP binding site [chemical binding]; other site 868595007875 Walker B motif; other site 868595007876 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 868595007877 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 868595007878 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 868595007879 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 868595007880 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 868595007881 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 868595007882 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 868595007883 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 868595007884 ATP synthase I chain; Region: ATP_synt_I; pfam03899 868595007885 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 868595007886 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 868595007887 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 868595007888 active site 868595007889 homodimer interface [polypeptide binding]; other site 868595007890 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 868595007891 four helix bundle protein; Region: TIGR02436 868595007892 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 868595007893 homodimer interface [polypeptide binding]; other site 868595007894 metal binding site [ion binding]; metal-binding site 868595007895 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 868595007896 catalytic motif [active] 868595007897 Zn binding site [ion binding]; other site 868595007898 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 868595007899 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 868595007900 dimer interface [polypeptide binding]; other site 868595007901 active site 868595007902 glycine-pyridoxal phosphate binding site [chemical binding]; other site 868595007903 folate binding site [chemical binding]; other site 868595007904 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 868595007905 Low molecular weight phosphatase family; Region: LMWPc; cd00115 868595007906 active site 868595007907 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 868595007908 Domain of unknown function DUF; Region: DUF204; pfam02659 868595007909 Domain of unknown function DUF; Region: DUF204; pfam02659 868595007910 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 868595007911 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 868595007912 High-affinity nickel-transport protein; Region: NicO; cl00964 868595007913 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 868595007914 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 868595007915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595007916 S-adenosylmethionine binding site [chemical binding]; other site 868595007917 peptide chain release factor 1; Validated; Region: prfA; PRK00591 868595007918 This domain is found in peptide chain release factors; Region: PCRF; smart00937 868595007919 RF-1 domain; Region: RF-1; pfam00472 868595007920 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 868595007921 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 868595007922 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 868595007923 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 868595007924 Peptidase family M23; Region: Peptidase_M23; pfam01551 868595007925 transcription termination factor Rho; Provisional; Region: rho; PRK09376 868595007926 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 868595007927 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 868595007928 RNA binding site [nucleotide binding]; other site 868595007929 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 868595007930 multimer interface [polypeptide binding]; other site 868595007931 Walker A motif; other site 868595007932 ATP binding site [chemical binding]; other site 868595007933 Walker B motif; other site 868595007934 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 868595007935 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 868595007936 active site 868595007937 intersubunit interactions; other site 868595007938 catalytic residue [active] 868595007939 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 868595007940 intersubunit interface [polypeptide binding]; other site 868595007941 active site 868595007942 zinc binding site [ion binding]; other site 868595007943 Na+ binding site [ion binding]; other site 868595007944 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 868595007945 Response regulator receiver domain; Region: Response_reg; pfam00072 868595007946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 868595007947 active site 868595007948 phosphorylation site [posttranslational modification] 868595007949 intermolecular recognition site; other site 868595007950 dimerization interface [polypeptide binding]; other site 868595007951 Yip1 domain; Region: Yip1; pfam04893 868595007952 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 868595007953 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 868595007954 tandem repeat interface [polypeptide binding]; other site 868595007955 oligomer interface [polypeptide binding]; other site 868595007956 active site residues [active] 868595007957 CTP synthetase; Validated; Region: pyrG; PRK05380 868595007958 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 868595007959 Catalytic site [active] 868595007960 active site 868595007961 UTP binding site [chemical binding]; other site 868595007962 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 868595007963 active site 868595007964 putative oxyanion hole; other site 868595007965 catalytic triad [active] 868595007966 XapX domain; Region: XapX; TIGR03510 868595007967 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 868595007968 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 868595007969 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 868595007970 active site 868595007971 HIGH motif; other site 868595007972 KMSK motif region; other site 868595007973 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 868595007974 tRNA binding surface [nucleotide binding]; other site 868595007975 anticodon binding site; other site 868595007976 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 868595007977 Adenosine deaminase z-alpha domain; Region: z-alpha; cl02659 868595007978 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 868595007979 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 868595007980 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 868595007981 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 868595007982 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 868595007983 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 868595007984 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 868595007985 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 868595007986 dimer interface [polypeptide binding]; other site 868595007987 PYR/PP interface [polypeptide binding]; other site 868595007988 TPP binding site [chemical binding]; other site 868595007989 substrate binding site [chemical binding]; other site 868595007990 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 868595007991 TPP-binding site; other site 868595007992 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 868595007993 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 868595007994 acyl-activating enzyme (AAE) consensus motif; other site 868595007995 AMP binding site [chemical binding]; other site 868595007996 active site 868595007997 CoA binding site [chemical binding]; other site 868595007998 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 868595007999 Na binding site [ion binding]; other site 868595008000 hypothetical protein; Validated; Region: PRK07682 868595008001 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 868595008002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 868595008003 homodimer interface [polypeptide binding]; other site 868595008004 catalytic residue [active] 868595008005 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 868595008006 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 868595008007 AsnC family; Region: AsnC_trans_reg; pfam01037 868595008008 germination protein YpeB; Region: spore_YpeB; TIGR02889 868595008009 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 868595008010 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 868595008011 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 868595008012 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 868595008013 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 868595008014 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 868595008015 catalytic triad [active] 868595008016 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 868595008017 DsrC like protein; Region: DsrC; pfam04358 868595008018 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 868595008019 Cysteine-rich domain; Region: CCG; pfam02754 868595008020 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 868595008021 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 868595008022 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 868595008023 Protein of unknown function (DUF964); Region: DUF964; pfam06133 868595008024 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 868595008025 DctM-like transporters; Region: DctM; pfam06808 868595008026 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 868595008027 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 868595008028 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 868595008029 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 868595008030 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 868595008031 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 868595008032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595008033 S-adenosylmethionine binding site [chemical binding]; other site 868595008034 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 868595008035 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 868595008036 amino acid carrier protein; Region: agcS; TIGR00835 868595008037 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 868595008038 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 868595008039 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 868595008040 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 868595008041 putative NADH binding site [chemical binding]; other site 868595008042 putative active site [active] 868595008043 nudix motif; other site 868595008044 putative metal binding site [ion binding]; other site 868595008045 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 868595008046 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 868595008047 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 868595008048 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 868595008049 Zn2+ binding site [ion binding]; other site 868595008050 Mg2+ binding site [ion binding]; other site 868595008051 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 868595008052 anti sigma factor interaction site; other site 868595008053 regulatory phosphorylation site [posttranslational modification]; other site 868595008054 Protein of unknown function (DUF342); Region: DUF342; pfam03961 868595008055 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 868595008056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 868595008057 ATP binding site [chemical binding]; other site 868595008058 Mg2+ binding site [ion binding]; other site 868595008059 G-X-G motif; other site 868595008060 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 868595008061 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 868595008062 amino acid carrier protein; Region: agcS; TIGR00835 868595008063 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 868595008064 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 868595008065 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 868595008066 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 868595008067 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 868595008068 dimerization domain swap beta strand [polypeptide binding]; other site 868595008069 regulatory protein interface [polypeptide binding]; other site 868595008070 active site 868595008071 regulatory phosphorylation site [posttranslational modification]; other site 868595008072 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 868595008073 active site 868595008074 phosphorylation site [posttranslational modification] 868595008075 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 868595008076 active site 868595008077 P-loop; other site 868595008078 phosphorylation site [posttranslational modification] 868595008079 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 868595008080 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 868595008081 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 868595008082 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 868595008083 putative substrate binding site [chemical binding]; other site 868595008084 putative ATP binding site [chemical binding]; other site 868595008085 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 868595008086 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 868595008087 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 868595008088 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 868595008089 Membrane transport protein; Region: Mem_trans; cl09117 868595008090 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 868595008091 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 868595008092 catalytic triad [active] 868595008093 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 868595008094 FMN binding site [chemical binding]; other site 868595008095 dimer interface [polypeptide binding]; other site 868595008096 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 868595008097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595008098 FeS/SAM binding site; other site 868595008099 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 868595008100 dimerization interface [polypeptide binding]; other site 868595008101 putative DNA binding site [nucleotide binding]; other site 868595008102 putative Zn2+ binding site [ion binding]; other site 868595008103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 868595008104 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 868595008105 active site 868595008106 motif I; other site 868595008107 motif II; other site 868595008108 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 868595008109 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 868595008110 nudix motif; other site 868595008111 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 868595008112 putative deacylase active site [active] 868595008113 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 868595008114 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 868595008115 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 868595008116 hinge; other site 868595008117 active site 868595008118 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 868595008119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 868595008120 binding surface 868595008121 TPR motif; other site 868595008122 TPR repeat; Region: TPR_11; pfam13414 868595008123 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 868595008124 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 868595008125 G5 domain; Region: G5; pfam07501 868595008126 Peptidase family M23; Region: Peptidase_M23; pfam01551 868595008127 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 868595008128 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 868595008129 FeS/SAM binding site; other site 868595008130 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 868595008131 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 868595008132 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 868595008133 GDP-binding site [chemical binding]; other site 868595008134 ACT binding site; other site 868595008135 IMP binding site; other site 868595008136 replicative DNA helicase; Region: DnaB; TIGR00665 868595008137 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 868595008138 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 868595008139 Walker A motif; other site 868595008140 ATP binding site [chemical binding]; other site 868595008141 Walker B motif; other site 868595008142 DNA binding loops [nucleotide binding] 868595008143 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 868595008144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 868595008145 Walker A motif; other site 868595008146 ATP binding site [chemical binding]; other site 868595008147 Walker B motif; other site 868595008148 arginine finger; other site 868595008149 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 868595008150 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 868595008151 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 868595008152 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 868595008153 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 868595008154 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 868595008155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 868595008156 putative substrate translocation pore; other site 868595008157 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 868595008158 MarR family; Region: MarR; pfam01047 868595008159 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 868595008160 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 868595008161 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 868595008162 dimer interface [polypeptide binding]; other site 868595008163 ssDNA binding site [nucleotide binding]; other site 868595008164 tetramer (dimer of dimers) interface [polypeptide binding]; other site 868595008165 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 868595008166 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 868595008167 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 868595008168 Mechanosensitive ion channel; Region: MS_channel; pfam00924 868595008169 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 868595008170 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 868595008171 oligomer interface [polypeptide binding]; other site 868595008172 putative active site [active] 868595008173 metal binding site [ion binding]; metal-binding site 868595008174 Colicin V production protein; Region: Colicin_V; pfam02674 868595008175 Colicin V production protein; Region: Colicin_V; pfam02674 868595008176 Uncharacterized membrane protein [Function unknown]; Region: COG3949 868595008177 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 868595008178 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 868595008179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 868595008180 active site 868595008181 Protein of unknown function DUF111; Region: DUF111; pfam01969 868595008182 Protein of unknown function (DUF554); Region: DUF554; pfam04474 868595008183 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 868595008184 ParB-like nuclease domain; Region: ParB; smart00470 868595008185 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 868595008186 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 868595008187 P-loop; other site 868595008188 Magnesium ion binding site [ion binding]; other site 868595008189 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 868595008190 Magnesium ion binding site [ion binding]; other site 868595008191 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 868595008192 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 868595008193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 868595008194 S-adenosylmethionine binding site [chemical binding]; other site 868595008195 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 868595008196 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 868595008197 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 868595008198 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 868595008199 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 868595008200 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 868595008201 trmE is a tRNA modification GTPase; Region: trmE; cd04164 868595008202 G1 box; other site 868595008203 GTP/Mg2+ binding site [chemical binding]; other site 868595008204 Switch I region; other site 868595008205 G2 box; other site 868595008206 Switch II region; other site 868595008207 G3 box; other site 868595008208 G4 box; other site 868595008209 G5 box; other site 868595008210 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 868595008211 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 868595008212 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 868595008213 ribonuclease P; Reviewed; Region: rnpA; PRK00499