-- dump date 20140619_063722 -- class Genbank::misc_feature -- table misc_feature_note -- id note 767817000001 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 767817000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 767817000003 DnaA N-terminal domain; Region: DnaA_N; pfam11638 767817000004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817000005 Walker A motif; other site 767817000006 ATP binding site [chemical binding]; other site 767817000007 Walker B motif; other site 767817000008 arginine finger; other site 767817000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 767817000010 DnaA box-binding interface [nucleotide binding]; other site 767817000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 767817000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 767817000013 putative DNA binding surface [nucleotide binding]; other site 767817000014 dimer interface [polypeptide binding]; other site 767817000015 beta-clamp/clamp loader binding surface; other site 767817000016 beta-clamp/translesion DNA polymerase binding surface; other site 767817000017 S4 domain; Region: S4_2; pfam13275 767817000018 recombination protein F; Reviewed; Region: recF; PRK00064 767817000019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817000020 Walker A/P-loop; other site 767817000021 ATP binding site [chemical binding]; other site 767817000022 Q-loop/lid; other site 767817000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817000024 ABC transporter signature motif; other site 767817000025 Walker B; other site 767817000026 D-loop; other site 767817000027 H-loop/switch region; other site 767817000028 Domain of unknown function (DUF370); Region: DUF370; cl00898 767817000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 767817000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817000031 Mg2+ binding site [ion binding]; other site 767817000032 G-X-G motif; other site 767817000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 767817000034 anchoring element; other site 767817000035 dimer interface [polypeptide binding]; other site 767817000036 ATP binding site [chemical binding]; other site 767817000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 767817000038 active site 767817000039 putative metal-binding site [ion binding]; other site 767817000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 767817000041 DNA gyrase subunit A; Validated; Region: PRK05560 767817000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 767817000043 CAP-like domain; other site 767817000044 active site 767817000045 primary dimer interface [polypeptide binding]; other site 767817000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767817000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767817000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767817000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767817000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767817000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767817000052 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 767817000053 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 767817000054 active site 767817000055 multimer interface [polypeptide binding]; other site 767817000056 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 767817000057 predicted active site [active] 767817000058 catalytic triad [active] 767817000059 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 767817000060 homodimer interface [polypeptide binding]; other site 767817000061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817000062 catalytic residue [active] 767817000063 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 767817000064 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 767817000065 ligand binding site [chemical binding]; other site 767817000066 NAD binding site [chemical binding]; other site 767817000067 dimerization interface [polypeptide binding]; other site 767817000068 catalytic site [active] 767817000069 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 767817000070 putative L-serine binding site [chemical binding]; other site 767817000071 seryl-tRNA synthetase; Provisional; Region: PRK05431 767817000072 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 767817000073 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 767817000074 dimer interface [polypeptide binding]; other site 767817000075 active site 767817000076 motif 1; other site 767817000077 motif 2; other site 767817000078 motif 3; other site 767817000079 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 767817000080 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 767817000081 Int/Topo IB signature motif; other site 767817000082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817000083 non-specific DNA binding site [nucleotide binding]; other site 767817000084 salt bridge; other site 767817000085 sequence-specific DNA binding site [nucleotide binding]; other site 767817000086 Helix-turn-helix domain; Region: HTH_17; pfam12728 767817000087 CHC2 zinc finger; Region: zf-CHC2; cl17510 767817000088 Virulence-associated protein E; Region: VirE; pfam05272 767817000089 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 767817000090 G3 box; other site 767817000091 Switch II region; other site 767817000092 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 767817000093 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 767817000094 Phage capsid family; Region: Phage_capsid; pfam05065 767817000095 Phage-related minor tail protein [Function unknown]; Region: COG5280 767817000096 Phage-related minor tail protein [Function unknown]; Region: COG5280 767817000097 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cd01901 767817000098 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 767817000099 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 767817000100 nucleoside/Zn binding site; other site 767817000101 dimer interface [polypeptide binding]; other site 767817000102 catalytic motif [active] 767817000103 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 767817000104 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 767817000105 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 767817000106 hypothetical protein; Provisional; Region: PRK08236 767817000107 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 767817000108 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 767817000109 DNA-binding site [nucleotide binding]; DNA binding site 767817000110 RNA-binding motif; other site 767817000111 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817000112 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 767817000113 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817000114 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 767817000115 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 767817000116 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 767817000117 DctM-like transporters; Region: DctM; pfam06808 767817000118 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 767817000119 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 767817000120 flavoprotein, HI0933 family; Region: TIGR00275 767817000121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767817000122 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 767817000123 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 767817000124 ATP binding site [chemical binding]; other site 767817000125 Mg++ binding site [ion binding]; other site 767817000126 motif III; other site 767817000127 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817000128 nucleotide binding region [chemical binding]; other site 767817000129 ATP-binding site [chemical binding]; other site 767817000130 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 767817000131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817000132 Walker A motif; other site 767817000133 ATP binding site [chemical binding]; other site 767817000134 Walker B motif; other site 767817000135 arginine finger; other site 767817000136 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 767817000137 hypothetical protein; Validated; Region: PRK00153 767817000138 recombination protein RecR; Reviewed; Region: recR; PRK00076 767817000139 RecR protein; Region: RecR; pfam02132 767817000140 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 767817000141 putative active site [active] 767817000142 putative metal-binding site [ion binding]; other site 767817000143 tetramer interface [polypeptide binding]; other site 767817000144 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 767817000145 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 767817000146 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 767817000147 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 767817000148 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 767817000149 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 767817000150 DctM-like transporters; Region: DctM; pfam06808 767817000151 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 767817000152 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 767817000153 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 767817000154 Iron-sulfur protein interface; other site 767817000155 proximal heme binding site [chemical binding]; other site 767817000156 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 767817000157 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817000158 catalytic loop [active] 767817000159 iron binding site [ion binding]; other site 767817000160 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 767817000161 L-aspartate oxidase; Provisional; Region: PRK06175 767817000162 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 767817000163 Transcriptional regulators [Transcription]; Region: FadR; COG2186 767817000164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767817000165 DNA-binding site [nucleotide binding]; DNA binding site 767817000166 FCD domain; Region: FCD; pfam07729 767817000167 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 767817000168 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 767817000169 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 767817000170 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 767817000171 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 767817000172 dimer interface [polypeptide binding]; other site 767817000173 PYR/PP interface [polypeptide binding]; other site 767817000174 TPP binding site [chemical binding]; other site 767817000175 substrate binding site [chemical binding]; other site 767817000176 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767817000177 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 767817000178 TPP-binding site [chemical binding]; other site 767817000179 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 767817000180 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817000181 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 767817000182 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 767817000183 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767817000184 catalytic residue [active] 767817000185 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 767817000186 thymidylate kinase; Validated; Region: tmk; PRK00698 767817000187 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 767817000188 TMP-binding site; other site 767817000189 ATP-binding site [chemical binding]; other site 767817000190 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 767817000191 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 767817000192 DNA polymerase III subunit delta'; Validated; Region: PRK08485 767817000193 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 767817000194 Protein of unknown function (DUF972); Region: DUF972; pfam06156 767817000195 Predicted methyltransferases [General function prediction only]; Region: COG0313 767817000196 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 767817000197 putative SAM binding site [chemical binding]; other site 767817000198 putative homodimer interface [polypeptide binding]; other site 767817000199 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 767817000200 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 767817000201 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 767817000202 active site 767817000203 HIGH motif; other site 767817000204 KMSKS motif; other site 767817000205 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 767817000206 tRNA binding surface [nucleotide binding]; other site 767817000207 anticodon binding site; other site 767817000208 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 767817000209 active site 767817000210 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 767817000211 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 767817000212 homodimer interface [polypeptide binding]; other site 767817000213 Walker A motif; other site 767817000214 ATP binding site [chemical binding]; other site 767817000215 hydroxycobalamin binding site [chemical binding]; other site 767817000216 Walker B motif; other site 767817000217 Domain of unknown function (DUF348); Region: DUF348; pfam03990 767817000218 G5 domain; Region: G5; pfam07501 767817000219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 767817000220 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 767817000221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817000222 S-adenosylmethionine binding site [chemical binding]; other site 767817000223 Protein of unknown function (DUF458); Region: DUF458; pfam04308 767817000224 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767817000225 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 767817000226 active site 767817000227 YabG peptidase U57; Region: Peptidase_U57; pfam05582 767817000228 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 767817000229 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 767817000230 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 767817000231 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 767817000232 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 767817000233 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 767817000234 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 767817000235 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 767817000236 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817000237 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 767817000238 Heavy-metal-associated domain; Region: HMA; pfam00403 767817000239 Protein of unknown function, DUF606; Region: DUF606; pfam04657 767817000240 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 767817000241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 767817000242 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767817000243 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817000244 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 767817000245 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 767817000246 Transcriptional regulators [Transcription]; Region: GntR; COG1802 767817000247 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767817000248 DNA-binding site [nucleotide binding]; DNA binding site 767817000249 FCD domain; Region: FCD; pfam07729 767817000250 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 767817000251 regulatory protein SpoVG; Reviewed; Region: PRK13259 767817000252 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 767817000253 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 767817000254 Substrate binding site; other site 767817000255 Mg++ binding site; other site 767817000256 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 767817000257 active site 767817000258 substrate binding site [chemical binding]; other site 767817000259 CoA binding site [chemical binding]; other site 767817000260 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 767817000261 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 767817000262 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767817000263 active site 767817000264 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 767817000265 PRC-barrel domain; Region: PRC; pfam05239 767817000266 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 767817000267 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 767817000268 5S rRNA interface [nucleotide binding]; other site 767817000269 CTC domain interface [polypeptide binding]; other site 767817000270 L16 interface [polypeptide binding]; other site 767817000271 Fic family protein [Function unknown]; Region: COG3177 767817000272 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 767817000273 Fic/DOC family; Region: Fic; pfam02661 767817000274 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 767817000275 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 767817000276 active site 767817000277 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 767817000278 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767817000279 active site 767817000280 metal binding site [ion binding]; metal-binding site 767817000281 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 767817000282 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 767817000283 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 767817000284 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 767817000285 putative active site [active] 767817000286 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253 767817000287 putative tRNAtyr binding site [nucleotide binding]; other site 767817000288 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 767817000289 putative active site [active] 767817000290 catalytic residue [active] 767817000291 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 767817000292 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 767817000293 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817000294 ATP binding site [chemical binding]; other site 767817000295 putative Mg++ binding site [ion binding]; other site 767817000296 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817000297 nucleotide binding region [chemical binding]; other site 767817000298 ATP-binding site [chemical binding]; other site 767817000299 TRCF domain; Region: TRCF; pfam03461 767817000300 SurA N-terminal domain; Region: SurA_N_3; cl07813 767817000301 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 767817000302 stage V sporulation protein T; Region: spore_V_T; TIGR02851 767817000303 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 767817000304 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 767817000305 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 767817000306 putative SAM binding site [chemical binding]; other site 767817000307 putative homodimer interface [polypeptide binding]; other site 767817000308 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 767817000309 homodimer interface [polypeptide binding]; other site 767817000310 metal binding site [ion binding]; metal-binding site 767817000311 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 767817000312 homodimer interface [polypeptide binding]; other site 767817000313 active site 767817000314 putative chemical substrate binding site [chemical binding]; other site 767817000315 metal binding site [ion binding]; metal-binding site 767817000316 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 767817000317 IHF - DNA interface [nucleotide binding]; other site 767817000318 IHF dimer interface [polypeptide binding]; other site 767817000319 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767817000320 RNA binding surface [nucleotide binding]; other site 767817000321 Stage II sporulation protein; Region: SpoIID; pfam08486 767817000322 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 767817000323 YabP family; Region: YabP; cl06766 767817000324 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578 767817000325 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 767817000326 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 767817000327 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 767817000328 Septum formation initiator; Region: DivIC; pfam04977 767817000329 hypothetical protein; Provisional; Region: PRK08582 767817000330 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 767817000331 RNA binding site [nucleotide binding]; other site 767817000332 exopolyphosphatase; Region: exo_poly_only; TIGR03706 767817000333 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767817000334 nucleotide binding site [chemical binding]; other site 767817000335 stage II sporulation protein E; Region: spore_II_E; TIGR02865 767817000336 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 767817000337 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 767817000338 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 767817000339 Ligand Binding Site [chemical binding]; other site 767817000340 TilS substrate C-terminal domain; Region: TilS_C; smart00977 767817000341 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 767817000342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817000343 Walker A motif; other site 767817000344 ATP binding site [chemical binding]; other site 767817000345 Walker B motif; other site 767817000346 arginine finger; other site 767817000347 Peptidase family M41; Region: Peptidase_M41; pfam01434 767817000348 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 767817000349 active site 767817000350 multimer interface [polypeptide binding]; other site 767817000351 Predicted thioesterase [General function prediction only]; Region: COG5496 767817000352 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 767817000353 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 767817000354 Potassium binding sites [ion binding]; other site 767817000355 Cesium cation binding sites [ion binding]; other site 767817000356 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 767817000357 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767817000358 DNA binding residues [nucleotide binding] 767817000359 HD domain; Region: HD; pfam01966 767817000360 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 767817000361 dihydropteroate synthase; Region: DHPS; TIGR01496 767817000362 substrate binding pocket [chemical binding]; other site 767817000363 dimer interface [polypeptide binding]; other site 767817000364 inhibitor binding site; inhibition site 767817000365 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 767817000366 homooctamer interface [polypeptide binding]; other site 767817000367 active site 767817000368 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 767817000369 catalytic center binding site [active] 767817000370 ATP binding site [chemical binding]; other site 767817000371 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 767817000372 dimer interface [polypeptide binding]; other site 767817000373 substrate binding site [chemical binding]; other site 767817000374 ATP binding site [chemical binding]; other site 767817000375 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767817000376 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 767817000377 YwpF-like protein; Region: YwpF; pfam14183 767817000378 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 767817000379 nucleotide binding site/active site [active] 767817000380 HIT family signature motif; other site 767817000381 catalytic residue [active] 767817000382 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 767817000383 active site 767817000384 8-oxo-dGMP binding site [chemical binding]; other site 767817000385 nudix motif; other site 767817000386 metal binding site [ion binding]; metal-binding site 767817000387 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 767817000388 active site 767817000389 SUMO-1 interface [polypeptide binding]; other site 767817000390 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 767817000391 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 767817000392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817000393 active site 767817000394 phosphorylation site [posttranslational modification] 767817000395 intermolecular recognition site; other site 767817000396 dimerization interface [polypeptide binding]; other site 767817000397 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 767817000398 DNA binding residues [nucleotide binding] 767817000399 dimerization interface [polypeptide binding]; other site 767817000400 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 767817000401 CHASE3 domain; Region: CHASE3; cl05000 767817000402 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 767817000403 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817000404 dimerization interface [polypeptide binding]; other site 767817000405 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 767817000406 dimer interface [polypeptide binding]; other site 767817000407 putative CheW interface [polypeptide binding]; other site 767817000408 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 767817000409 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817000410 dimerization interface [polypeptide binding]; other site 767817000411 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 767817000412 dimer interface [polypeptide binding]; other site 767817000413 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 767817000414 putative CheW interface [polypeptide binding]; other site 767817000415 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 767817000416 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817000417 active site 767817000418 DNA binding site [nucleotide binding] 767817000419 Int/Topo IB signature motif; other site 767817000420 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 767817000421 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 767817000422 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817000423 dimerization interface [polypeptide binding]; other site 767817000424 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 767817000425 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 767817000426 dimer interface [polypeptide binding]; other site 767817000427 putative CheW interface [polypeptide binding]; other site 767817000428 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 767817000429 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 767817000430 putative active site [active] 767817000431 homotetrameric interface [polypeptide binding]; other site 767817000432 metal binding site [ion binding]; metal-binding site 767817000433 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 767817000434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817000435 Coenzyme A binding pocket [chemical binding]; other site 767817000436 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 767817000437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817000438 FeS/SAM binding site; other site 767817000439 Methyltransferase domain; Region: Methyltransf_23; pfam13489 767817000440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817000441 S-adenosylmethionine binding site [chemical binding]; other site 767817000442 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 767817000443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817000444 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817000445 DNA binding residues [nucleotide binding] 767817000446 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 767817000447 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 767817000448 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 767817000449 putative active site [active] 767817000450 homotetrameric interface [polypeptide binding]; other site 767817000451 metal binding site [ion binding]; metal-binding site 767817000452 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767817000453 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767817000454 Walker A/P-loop; other site 767817000455 ATP binding site [chemical binding]; other site 767817000456 Q-loop/lid; other site 767817000457 ABC transporter signature motif; other site 767817000458 Walker B; other site 767817000459 D-loop; other site 767817000460 H-loop/switch region; other site 767817000461 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767817000462 FtsX-like permease family; Region: FtsX; pfam02687 767817000463 FtsX-like permease family; Region: FtsX; pfam02687 767817000464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817000465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817000466 active site 767817000467 phosphorylation site [posttranslational modification] 767817000468 intermolecular recognition site; other site 767817000469 dimerization interface [polypeptide binding]; other site 767817000470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817000471 DNA binding site [nucleotide binding] 767817000472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817000473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 767817000474 dimer interface [polypeptide binding]; other site 767817000475 phosphorylation site [posttranslational modification] 767817000476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817000477 ATP binding site [chemical binding]; other site 767817000478 Mg2+ binding site [ion binding]; other site 767817000479 G-X-G motif; other site 767817000480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817000481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817000482 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 767817000483 phosphoenolpyruvate synthase; Validated; Region: PRK06241 767817000484 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 767817000485 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 767817000486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767817000487 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767817000488 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 767817000489 Leucine carboxyl methyltransferase; Region: LCM; cl01306 767817000490 Methyltransferase domain; Region: Methyltransf_23; pfam13489 767817000491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817000492 S-adenosylmethionine binding site [chemical binding]; other site 767817000493 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 767817000494 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767817000495 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767817000496 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 767817000497 oligomeric interface; other site 767817000498 putative active site [active] 767817000499 homodimer interface [polypeptide binding]; other site 767817000500 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 767817000501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 767817000502 DNA binding residues [nucleotide binding] 767817000503 dimerization interface [polypeptide binding]; other site 767817000504 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767817000505 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767817000506 Walker A/P-loop; other site 767817000507 ATP binding site [chemical binding]; other site 767817000508 Q-loop/lid; other site 767817000509 ABC transporter signature motif; other site 767817000510 Walker B; other site 767817000511 D-loop; other site 767817000512 H-loop/switch region; other site 767817000513 Predicted transcriptional regulators [Transcription]; Region: COG1725 767817000514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767817000515 DNA-binding site [nucleotide binding]; DNA binding site 767817000516 AAA domain; Region: AAA_14; pfam13173 767817000517 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 767817000518 Transposase domain (DUF772); Region: DUF772; pfam05598 767817000519 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767817000520 Predicted transcriptional regulators [Transcription]; Region: COG1725 767817000521 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 767817000522 HsdM N-terminal domain; Region: HsdM_N; pfam12161 767817000523 Methyltransferase domain; Region: Methyltransf_26; pfam13659 767817000524 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767817000525 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 767817000526 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767817000527 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 767817000528 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 767817000529 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817000530 ATP binding site [chemical binding]; other site 767817000531 putative Mg++ binding site [ion binding]; other site 767817000532 Protein of unknown function DUF45; Region: DUF45; pfam01863 767817000533 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 767817000534 HEAT repeats; Region: HEAT_2; pfam13646 767817000535 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 767817000536 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 767817000537 Fic family protein [Function unknown]; Region: COG3177 767817000538 Fic/DOC family; Region: Fic; pfam02661 767817000539 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 767817000540 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 767817000541 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 767817000542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817000543 ATP binding site [chemical binding]; other site 767817000544 putative Mg++ binding site [ion binding]; other site 767817000545 HsdM N-terminal domain; Region: HsdM_N; pfam12161 767817000546 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 767817000547 Methyltransferase domain; Region: Methyltransf_26; pfam13659 767817000548 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 767817000549 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767817000550 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767817000551 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 767817000552 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817000553 FeS/SAM binding site; other site 767817000554 Methyltransferase domain; Region: Methyltransf_23; pfam13489 767817000555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817000556 S-adenosylmethionine binding site [chemical binding]; other site 767817000557 DNA topoisomerase III; Provisional; Region: PRK07726 767817000558 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 767817000559 active site 767817000560 putative interdomain interaction site [polypeptide binding]; other site 767817000561 putative metal-binding site [ion binding]; other site 767817000562 putative nucleotide binding site [chemical binding]; other site 767817000563 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 767817000564 domain I; other site 767817000565 DNA binding groove [nucleotide binding] 767817000566 phosphate binding site [ion binding]; other site 767817000567 domain II; other site 767817000568 domain III; other site 767817000569 nucleotide binding site [chemical binding]; other site 767817000570 catalytic site [active] 767817000571 domain IV; other site 767817000572 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 767817000573 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817000574 catalytic loop [active] 767817000575 iron binding site [ion binding]; other site 767817000576 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 767817000577 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 767817000578 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 767817000579 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 767817000580 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 767817000581 putative MPT binding site; other site 767817000582 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 767817000583 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817000584 catalytic loop [active] 767817000585 iron binding site [ion binding]; other site 767817000586 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 767817000587 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 767817000588 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 767817000589 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 767817000590 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767817000591 Cysteine-rich domain; Region: CCG; pfam02754 767817000592 Methyltransferase domain; Region: Methyltransf_23; pfam13489 767817000593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817000594 S-adenosylmethionine binding site [chemical binding]; other site 767817000595 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 767817000596 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817000597 Radical SAM superfamily; Region: Radical_SAM; pfam04055 767817000598 FeS/SAM binding site; other site 767817000599 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 767817000600 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817000601 acyl-activating enzyme (AAE) consensus motif; other site 767817000602 active site 767817000603 AMP binding site [chemical binding]; other site 767817000604 CoA binding site [chemical binding]; other site 767817000605 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 767817000606 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 767817000607 XdhC Rossmann domain; Region: XdhC_C; pfam13478 767817000608 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 767817000609 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 767817000610 Ligand binding site; other site 767817000611 metal-binding site 767817000612 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817000613 Zn2+ binding site [ion binding]; other site 767817000614 Mg2+ binding site [ion binding]; other site 767817000615 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767817000616 catalytic core [active] 767817000617 Domain of unknown function (DUF364); Region: DUF364; pfam04016 767817000618 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 767817000619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817000620 Walker A/P-loop; other site 767817000621 ATP binding site [chemical binding]; other site 767817000622 Q-loop/lid; other site 767817000623 ABC transporter signature motif; other site 767817000624 Walker B; other site 767817000625 D-loop; other site 767817000626 H-loop/switch region; other site 767817000627 TOBE-like domain; Region: TOBE_3; pfam12857 767817000628 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 767817000629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817000630 dimer interface [polypeptide binding]; other site 767817000631 conserved gate region; other site 767817000632 putative PBP binding loops; other site 767817000633 ABC-ATPase subunit interface; other site 767817000634 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 767817000635 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767817000636 substrate binding pocket [chemical binding]; other site 767817000637 membrane-bound complex binding site; other site 767817000638 hinge residues; other site 767817000639 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 767817000640 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767817000641 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 767817000642 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767817000643 active site 767817000644 pantoate--beta-alanine ligase; Region: panC; TIGR00018 767817000645 Pantoate-beta-alanine ligase; Region: PanC; cd00560 767817000646 active site 767817000647 ATP-binding site [chemical binding]; other site 767817000648 pantoate-binding site; other site 767817000649 HXXH motif; other site 767817000650 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 767817000651 tetramerization interface [polypeptide binding]; other site 767817000652 active site 767817000653 Quinolinate synthetase A protein; Region: NadA; pfam02445 767817000654 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 767817000655 L-aspartate oxidase; Provisional; Region: PRK06175 767817000656 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 767817000657 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 767817000658 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 767817000659 dimerization interface [polypeptide binding]; other site 767817000660 active site 767817000661 Biotin operon repressor [Transcription]; Region: BirA; COG1654 767817000662 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 767817000663 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 767817000664 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 767817000665 BioY family; Region: BioY; pfam02632 767817000666 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 767817000667 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767817000668 active site 767817000669 metal binding site [ion binding]; metal-binding site 767817000670 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 767817000671 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 767817000672 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 767817000673 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 767817000674 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 767817000675 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 767817000676 Fn3 associated; Region: Fn3_assoc; pfam13287 767817000677 S-layer homology domain; Region: SLH; pfam00395 767817000678 S-layer homology domain; Region: SLH; pfam00395 767817000679 S-layer homology domain; Region: SLH; pfam00395 767817000680 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 767817000681 Fn3 associated; Region: Fn3_assoc; pfam13287 767817000682 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 767817000683 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 767817000684 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 767817000685 Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919 767817000686 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 767817000687 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 767817000688 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817000689 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817000690 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 767817000691 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 767817000692 Fn3 associated; Region: Fn3_assoc; pfam13287 767817000693 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 767817000694 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 767817000695 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 767817000696 Moco binding site; other site 767817000697 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 767817000698 metal coordination site [ion binding]; other site 767817000699 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 767817000700 Moco binding site; other site 767817000701 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 767817000702 Interdomain contacts; other site 767817000703 Cytokine receptor motif; other site 767817000704 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817000705 Moco binding site; other site 767817000706 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 767817000707 metal coordination site [ion binding]; other site 767817000708 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 767817000709 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 767817000710 Moco binding site; other site 767817000711 metal coordination site [ion binding]; other site 767817000712 4Fe-4S binding domain; Region: Fer4_5; pfam12801 767817000713 4Fe-4S binding domain; Region: Fer4_5; pfam12801 767817000714 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 767817000715 FMN-binding domain; Region: FMN_bind; cl01081 767817000716 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 767817000717 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 767817000718 Moco binding site; other site 767817000719 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767817000720 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767817000721 Walker A/P-loop; other site 767817000722 ATP binding site [chemical binding]; other site 767817000723 Q-loop/lid; other site 767817000724 ABC transporter signature motif; other site 767817000725 Walker B; other site 767817000726 D-loop; other site 767817000727 H-loop/switch region; other site 767817000728 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767817000729 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767817000730 Walker A/P-loop; other site 767817000731 ATP binding site [chemical binding]; other site 767817000732 Q-loop/lid; other site 767817000733 ABC transporter signature motif; other site 767817000734 Walker B; other site 767817000735 D-loop; other site 767817000736 H-loop/switch region; other site 767817000737 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 767817000738 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 767817000739 trimer interface [polypeptide binding]; other site 767817000740 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 767817000741 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 767817000742 Walker A motif; other site 767817000743 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 767817000744 active site 767817000745 ATP binding site [chemical binding]; other site 767817000746 substrate binding site [chemical binding]; other site 767817000747 pantothenate kinase; Reviewed; Region: PRK13318 767817000748 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 767817000749 FMN binding site [chemical binding]; other site 767817000750 active site 767817000751 catalytic residues [active] 767817000752 substrate binding site [chemical binding]; other site 767817000753 putative transcriptional regulator; Provisional; Region: tfx; cl17550 767817000754 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 767817000755 NAD(P) binding pocket [chemical binding]; other site 767817000756 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 767817000757 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 767817000758 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 767817000759 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 767817000760 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 767817000761 dimer interface [polypeptide binding]; other site 767817000762 putative anticodon binding site; other site 767817000763 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 767817000764 motif 1; other site 767817000765 active site 767817000766 motif 2; other site 767817000767 motif 3; other site 767817000768 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 767817000769 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 767817000770 ApbE family; Region: ApbE; pfam02424 767817000771 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817000772 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 767817000773 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 767817000774 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 767817000775 UvrB/uvrC motif; Region: UVR; pfam02151 767817000776 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 767817000777 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 767817000778 ADP binding site [chemical binding]; other site 767817000779 phosphagen binding site; other site 767817000780 substrate specificity loop; other site 767817000781 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 767817000782 Clp amino terminal domain; Region: Clp_N; pfam02861 767817000783 Clp amino terminal domain; Region: Clp_N; pfam02861 767817000784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817000785 Walker A motif; other site 767817000786 ATP binding site [chemical binding]; other site 767817000787 Walker B motif; other site 767817000788 arginine finger; other site 767817000789 UvrB/uvrC motif; Region: UVR; pfam02151 767817000790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817000791 Walker A motif; other site 767817000792 ATP binding site [chemical binding]; other site 767817000793 Walker B motif; other site 767817000794 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 767817000795 DNA repair protein RadA; Provisional; Region: PRK11823 767817000796 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 767817000797 Walker A motif/ATP binding site; other site 767817000798 ATP binding site [chemical binding]; other site 767817000799 Walker B motif; other site 767817000800 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 767817000801 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 767817000802 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 767817000803 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 767817000804 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 767817000805 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 767817000806 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 767817000807 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 767817000808 putative active site [active] 767817000809 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 767817000810 substrate binding site; other site 767817000811 dimer interface; other site 767817000812 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 767817000813 homotrimer interaction site [polypeptide binding]; other site 767817000814 zinc binding site [ion binding]; other site 767817000815 CDP-binding sites; other site 767817000816 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 767817000817 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 767817000818 HIGH motif; other site 767817000819 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 767817000820 active site 767817000821 KMSKS motif; other site 767817000822 serine O-acetyltransferase; Region: cysE; TIGR01172 767817000823 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 767817000824 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 767817000825 trimer interface [polypeptide binding]; other site 767817000826 active site 767817000827 substrate binding site [chemical binding]; other site 767817000828 CoA binding site [chemical binding]; other site 767817000829 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 767817000830 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 767817000831 active site 767817000832 HIGH motif; other site 767817000833 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 767817000834 KMSKS motif; other site 767817000835 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 767817000836 tRNA binding surface [nucleotide binding]; other site 767817000837 anticodon binding site; other site 767817000838 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 767817000839 active site 767817000840 metal binding site [ion binding]; metal-binding site 767817000841 dimerization interface [polypeptide binding]; other site 767817000842 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 767817000843 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 767817000844 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 767817000845 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 767817000846 YacP-like NYN domain; Region: NYN_YacP; pfam05991 767817000847 RNA polymerase factor sigma-70; Validated; Region: PRK08295 767817000848 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817000849 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 767817000850 elongation factor Tu; Reviewed; Region: PRK00049 767817000851 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 767817000852 G1 box; other site 767817000853 GEF interaction site [polypeptide binding]; other site 767817000854 GTP/Mg2+ binding site [chemical binding]; other site 767817000855 Switch I region; other site 767817000856 G2 box; other site 767817000857 G3 box; other site 767817000858 Switch II region; other site 767817000859 G4 box; other site 767817000860 G5 box; other site 767817000861 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 767817000862 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 767817000863 Antibiotic Binding Site [chemical binding]; other site 767817000864 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 767817000865 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 767817000866 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 767817000867 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 767817000868 putative homodimer interface [polypeptide binding]; other site 767817000869 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 767817000870 heterodimer interface [polypeptide binding]; other site 767817000871 homodimer interface [polypeptide binding]; other site 767817000872 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 767817000873 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 767817000874 23S rRNA interface [nucleotide binding]; other site 767817000875 L7/L12 interface [polypeptide binding]; other site 767817000876 putative thiostrepton binding site; other site 767817000877 L25 interface [polypeptide binding]; other site 767817000878 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 767817000879 mRNA/rRNA interface [nucleotide binding]; other site 767817000880 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 767817000881 23S rRNA interface [nucleotide binding]; other site 767817000882 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 767817000883 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 767817000884 peripheral dimer interface [polypeptide binding]; other site 767817000885 core dimer interface [polypeptide binding]; other site 767817000886 L10 interface [polypeptide binding]; other site 767817000887 L11 interface [polypeptide binding]; other site 767817000888 putative EF-Tu interaction site [polypeptide binding]; other site 767817000889 putative EF-G interaction site [polypeptide binding]; other site 767817000890 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 767817000891 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 767817000892 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 767817000893 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 767817000894 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 767817000895 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 767817000896 RPB1 interaction site [polypeptide binding]; other site 767817000897 RPB10 interaction site [polypeptide binding]; other site 767817000898 RPB11 interaction site [polypeptide binding]; other site 767817000899 RPB3 interaction site [polypeptide binding]; other site 767817000900 RPB12 interaction site [polypeptide binding]; other site 767817000901 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 767817000902 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 767817000903 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 767817000904 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 767817000905 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 767817000906 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 767817000907 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 767817000908 G-loop; other site 767817000909 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 767817000910 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 767817000911 DNA binding site [nucleotide binding] 767817000912 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 767817000913 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 767817000914 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 767817000915 S17 interaction site [polypeptide binding]; other site 767817000916 S8 interaction site; other site 767817000917 16S rRNA interaction site [nucleotide binding]; other site 767817000918 streptomycin interaction site [chemical binding]; other site 767817000919 23S rRNA interaction site [nucleotide binding]; other site 767817000920 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 767817000921 30S ribosomal protein S7; Validated; Region: PRK05302 767817000922 elongation factor G; Reviewed; Region: PRK00007 767817000923 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 767817000924 G1 box; other site 767817000925 putative GEF interaction site [polypeptide binding]; other site 767817000926 GTP/Mg2+ binding site [chemical binding]; other site 767817000927 Switch I region; other site 767817000928 G2 box; other site 767817000929 G3 box; other site 767817000930 Switch II region; other site 767817000931 G4 box; other site 767817000932 G5 box; other site 767817000933 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 767817000934 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 767817000935 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 767817000936 elongation factor Tu; Reviewed; Region: PRK00049 767817000937 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 767817000938 G1 box; other site 767817000939 GEF interaction site [polypeptide binding]; other site 767817000940 GTP/Mg2+ binding site [chemical binding]; other site 767817000941 Switch I region; other site 767817000942 G2 box; other site 767817000943 G3 box; other site 767817000944 Switch II region; other site 767817000945 G4 box; other site 767817000946 G5 box; other site 767817000947 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 767817000948 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 767817000949 Antibiotic Binding Site [chemical binding]; other site 767817000950 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 767817000951 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 767817000952 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 767817000953 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 767817000954 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 767817000955 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 767817000956 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 767817000957 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 767817000958 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 767817000959 putative translocon binding site; other site 767817000960 protein-rRNA interface [nucleotide binding]; other site 767817000961 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 767817000962 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 767817000963 G-X-X-G motif; other site 767817000964 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 767817000965 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 767817000966 23S rRNA interface [nucleotide binding]; other site 767817000967 5S rRNA interface [nucleotide binding]; other site 767817000968 putative antibiotic binding site [chemical binding]; other site 767817000969 L25 interface [polypeptide binding]; other site 767817000970 L27 interface [polypeptide binding]; other site 767817000971 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 767817000972 23S rRNA interface [nucleotide binding]; other site 767817000973 putative translocon interaction site; other site 767817000974 signal recognition particle (SRP54) interaction site; other site 767817000975 L23 interface [polypeptide binding]; other site 767817000976 trigger factor interaction site; other site 767817000977 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 767817000978 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 767817000979 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 767817000980 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 767817000981 RNA binding site [nucleotide binding]; other site 767817000982 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 767817000983 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 767817000984 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 767817000985 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 767817000986 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 767817000987 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 767817000988 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 767817000989 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 767817000990 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 767817000991 5S rRNA interface [nucleotide binding]; other site 767817000992 L27 interface [polypeptide binding]; other site 767817000993 23S rRNA interface [nucleotide binding]; other site 767817000994 L5 interface [polypeptide binding]; other site 767817000995 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 767817000996 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 767817000997 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 767817000998 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 767817000999 23S rRNA binding site [nucleotide binding]; other site 767817001000 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 767817001001 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 767817001002 SecY translocase; Region: SecY; pfam00344 767817001003 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 767817001004 active site 767817001005 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 767817001006 RNA binding site [nucleotide binding]; other site 767817001007 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 767817001008 rRNA binding site [nucleotide binding]; other site 767817001009 predicted 30S ribosome binding site; other site 767817001010 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 767817001011 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 767817001012 30S ribosomal protein S13; Region: bact_S13; TIGR03631 767817001013 30S ribosomal protein S11; Validated; Region: PRK05309 767817001014 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 767817001015 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 767817001016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767817001017 RNA binding surface [nucleotide binding]; other site 767817001018 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 767817001019 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 767817001020 alphaNTD - beta interaction site [polypeptide binding]; other site 767817001021 alphaNTD homodimer interface [polypeptide binding]; other site 767817001022 alphaNTD - beta' interaction site [polypeptide binding]; other site 767817001023 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 767817001024 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 767817001025 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 767817001026 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767817001027 Walker A/P-loop; other site 767817001028 ATP binding site [chemical binding]; other site 767817001029 Q-loop/lid; other site 767817001030 ABC transporter signature motif; other site 767817001031 Walker B; other site 767817001032 D-loop; other site 767817001033 H-loop/switch region; other site 767817001034 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 767817001035 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767817001036 Walker A/P-loop; other site 767817001037 ATP binding site [chemical binding]; other site 767817001038 Q-loop/lid; other site 767817001039 ABC transporter signature motif; other site 767817001040 Walker B; other site 767817001041 D-loop; other site 767817001042 H-loop/switch region; other site 767817001043 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 767817001044 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 767817001045 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 767817001046 dimerization interface 3.5A [polypeptide binding]; other site 767817001047 active site 767817001048 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 767817001049 23S rRNA interface [nucleotide binding]; other site 767817001050 L3 interface [polypeptide binding]; other site 767817001051 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 767817001052 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 767817001053 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 767817001054 active site 767817001055 metal binding site [ion binding]; metal-binding site 767817001056 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767817001057 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 767817001058 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767817001059 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 767817001060 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767817001061 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 767817001062 Predicted membrane protein [Function unknown]; Region: COG1238 767817001063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817001064 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817001065 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 767817001066 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 767817001067 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767817001068 active site 767817001069 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 767817001070 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 767817001071 dimer interface [polypeptide binding]; other site 767817001072 active site 767817001073 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 767817001074 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 767817001075 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 767817001076 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 767817001077 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817001078 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 767817001079 substrate binding site [chemical binding]; other site 767817001080 oxyanion hole (OAH) forming residues; other site 767817001081 trimer interface [polypeptide binding]; other site 767817001082 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 767817001083 hypothetical protein; Provisional; Region: PRK03881 767817001084 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 767817001085 AMMECR1; Region: AMMECR1; pfam01871 767817001086 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 767817001087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817001088 FeS/SAM binding site; other site 767817001089 NAD-dependent deacetylase; Provisional; Region: PRK00481 767817001090 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 767817001091 Helix-turn-helix domain; Region: HTH_17; pfam12728 767817001092 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817001093 ATP binding site [chemical binding]; other site 767817001094 putative Mg++ binding site [ion binding]; other site 767817001095 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817001096 nucleotide binding region [chemical binding]; other site 767817001097 ATP-binding site [chemical binding]; other site 767817001098 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 767817001099 Protein of unknown function (DUF441); Region: DUF441; pfam04284 767817001100 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 767817001101 active site 767817001102 NTP binding site [chemical binding]; other site 767817001103 metal binding triad [ion binding]; metal-binding site 767817001104 antibiotic binding site [chemical binding]; other site 767817001105 Uncharacterized conserved protein [Function unknown]; Region: COG2445 767817001106 4-hydroxybenzoyl-CoA reductase, beta subunit; Region: 4hydrxCoA_B; TIGR03195 767817001107 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 767817001108 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 767817001109 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 767817001110 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 767817001111 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 767817001112 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817001113 catalytic loop [active] 767817001114 iron binding site [ion binding]; other site 767817001115 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 767817001116 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 767817001117 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 767817001118 putative ligand binding residues [chemical binding]; other site 767817001119 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 767817001120 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 767817001121 MPT binding site; other site 767817001122 PemK-like protein; Region: PemK; cl00995 767817001123 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 767817001124 Predicted transcriptional regulators [Transcription]; Region: COG1695 767817001125 Transcriptional regulator PadR-like family; Region: PadR; cl17335 767817001126 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 767817001127 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817001128 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767817001129 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817001130 DNA binding residues [nucleotide binding] 767817001131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 767817001132 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 767817001133 MULE transposase domain; Region: MULE; pfam10551 767817001134 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767817001135 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817001136 DNA binding residues [nucleotide binding] 767817001137 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767817001138 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817001139 DNA binding residues [nucleotide binding] 767817001140 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 767817001141 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767817001142 MarR family; Region: MarR; pfam01047 767817001143 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817001144 4Fe-4S binding domain; Region: Fer4; pfam00037 767817001145 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 767817001146 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 767817001147 active site 767817001148 dimerization interface [polypeptide binding]; other site 767817001149 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 767817001150 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767817001151 Beta-Casp domain; Region: Beta-Casp; smart01027 767817001152 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817001153 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 767817001154 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 767817001155 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 767817001156 heterotetramer interface [polypeptide binding]; other site 767817001157 active site pocket [active] 767817001158 cleavage site 767817001159 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 767817001160 feedback inhibition sensing region; other site 767817001161 homohexameric interface [polypeptide binding]; other site 767817001162 nucleotide binding site [chemical binding]; other site 767817001163 N-acetyl-L-glutamate binding site [chemical binding]; other site 767817001164 acetylornithine aminotransferase; Provisional; Region: PRK02627 767817001165 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 767817001166 inhibitor-cofactor binding pocket; inhibition site 767817001167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817001168 catalytic residue [active] 767817001169 ornithine carbamoyltransferase; Provisional; Region: PRK00779 767817001170 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 767817001171 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 767817001172 argininosuccinate synthase; Provisional; Region: PRK13820 767817001173 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 767817001174 ANP binding site [chemical binding]; other site 767817001175 Substrate Binding Site II [chemical binding]; other site 767817001176 Substrate Binding Site I [chemical binding]; other site 767817001177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817001178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817001179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817001180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817001181 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 767817001182 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767817001183 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 767817001184 active site 767817001185 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 767817001186 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 767817001187 NAD binding site [chemical binding]; other site 767817001188 homodimer interface [polypeptide binding]; other site 767817001189 homotetramer interface [polypeptide binding]; other site 767817001190 active site 767817001191 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 767817001192 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817001193 substrate binding site [chemical binding]; other site 767817001194 oxyanion hole (OAH) forming residues; other site 767817001195 trimer interface [polypeptide binding]; other site 767817001196 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 767817001197 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 767817001198 dimer interface [polypeptide binding]; other site 767817001199 active site 767817001200 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 767817001201 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 767817001202 acyl-activating enzyme (AAE) consensus motif; other site 767817001203 putative AMP binding site [chemical binding]; other site 767817001204 putative active site [active] 767817001205 putative CoA binding site [chemical binding]; other site 767817001206 hypothetical protein; Provisional; Region: PRK04262 767817001207 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 767817001208 dimer interface [polypeptide binding]; other site 767817001209 active site 767817001210 DUF35 OB-fold domain; Region: DUF35; pfam01796 767817001211 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 767817001212 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 767817001213 active site 767817001214 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767817001215 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 767817001216 active site 767817001217 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 767817001218 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 767817001219 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 767817001220 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 767817001221 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817001222 substrate binding site [chemical binding]; other site 767817001223 oxyanion hole (OAH) forming residues; other site 767817001224 trimer interface [polypeptide binding]; other site 767817001225 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 767817001226 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817001227 substrate binding site [chemical binding]; other site 767817001228 oxyanion hole (OAH) forming residues; other site 767817001229 trimer interface [polypeptide binding]; other site 767817001230 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 767817001231 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 767817001232 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 767817001233 enoyl-CoA hydratase; Provisional; Region: PRK06688 767817001234 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817001235 substrate binding site [chemical binding]; other site 767817001236 oxyanion hole (OAH) forming residues; other site 767817001237 trimer interface [polypeptide binding]; other site 767817001238 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 767817001239 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 767817001240 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 767817001241 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 767817001242 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 767817001243 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767817001244 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767817001245 Cysteine-rich domain; Region: CCG; pfam02754 767817001246 Cysteine-rich domain; Region: CCG; pfam02754 767817001247 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 767817001248 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817001249 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767817001250 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817001251 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817001252 4Fe-4S binding domain; Region: Fer4; pfam00037 767817001253 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817001254 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 767817001255 4Fe-4S binding domain; Region: Fer4; pfam00037 767817001256 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 767817001257 4Fe-4S binding domain; Region: Fer4; pfam00037 767817001258 Nitroreductase family; Region: Nitroreductase; pfam00881 767817001259 FMN binding site [chemical binding]; other site 767817001260 dimer interface [polypeptide binding]; other site 767817001261 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 767817001262 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 767817001263 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 767817001264 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 767817001265 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817001266 PAS domain; Region: PAS_9; pfam13426 767817001267 putative active site [active] 767817001268 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 767817001269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817001270 Walker A motif; other site 767817001271 ATP binding site [chemical binding]; other site 767817001272 Walker B motif; other site 767817001273 arginine finger; other site 767817001274 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 767817001275 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 767817001276 putative [Fe4-S4] binding site [ion binding]; other site 767817001277 putative molybdopterin cofactor binding site [chemical binding]; other site 767817001278 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 767817001279 putative molybdopterin cofactor binding site; other site 767817001280 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 767817001281 4Fe-4S binding domain; Region: Fer4; pfam00037 767817001282 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 767817001283 FeS/SAM binding site; other site 767817001284 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767817001285 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 767817001286 active site 767817001287 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 767817001288 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 767817001289 acyl-activating enzyme (AAE) consensus motif; other site 767817001290 putative AMP binding site [chemical binding]; other site 767817001291 putative active site [active] 767817001292 putative CoA binding site [chemical binding]; other site 767817001293 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 767817001294 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 767817001295 acyl-activating enzyme (AAE) consensus motif; other site 767817001296 active site 767817001297 AMP binding site [chemical binding]; other site 767817001298 substrate binding site [chemical binding]; other site 767817001299 Cytochrome B561, N terminal; Region: CytochromB561_N; pfam09786 767817001300 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 767817001301 Na binding site [ion binding]; other site 767817001302 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 767817001303 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 767817001304 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 767817001305 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 767817001306 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817001307 substrate binding site [chemical binding]; other site 767817001308 oxyanion hole (OAH) forming residues; other site 767817001309 trimer interface [polypeptide binding]; other site 767817001310 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 767817001311 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 767817001312 active site 767817001313 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 767817001314 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 767817001315 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 767817001316 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 767817001317 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 767817001318 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817001319 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 767817001320 acyl-activating enzyme (AAE) consensus motif; other site 767817001321 acyl-activating enzyme (AAE) consensus motif; other site 767817001322 putative AMP binding site [chemical binding]; other site 767817001323 putative active site [active] 767817001324 putative CoA binding site [chemical binding]; other site 767817001325 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767817001326 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767817001327 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767817001328 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 767817001329 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 767817001330 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 767817001331 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 767817001332 benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; TIGR03190 767817001333 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 767817001334 benzoyl-CoA reductase, bzd-type, O subunit; Region: benz_CoA_bzdO; TIGR03191 767817001335 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 767817001336 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767817001337 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 767817001338 active site 767817001339 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817001340 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 767817001341 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 767817001342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817001343 putative active site [active] 767817001344 heme pocket [chemical binding]; other site 767817001345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817001346 putative active site [active] 767817001347 heme pocket [chemical binding]; other site 767817001348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817001349 Walker A motif; other site 767817001350 ATP binding site [chemical binding]; other site 767817001351 Walker B motif; other site 767817001352 arginine finger; other site 767817001353 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 767817001354 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 767817001355 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 767817001356 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 767817001357 active site 767817001358 NAD binding site [chemical binding]; other site 767817001359 metal binding site [ion binding]; metal-binding site 767817001360 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 767817001361 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 767817001362 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 767817001363 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767817001364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817001365 non-specific DNA binding site [nucleotide binding]; other site 767817001366 salt bridge; other site 767817001367 sequence-specific DNA binding site [nucleotide binding]; other site 767817001368 Cupin domain; Region: Cupin_2; cl17218 767817001369 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 767817001370 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 767817001371 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 767817001372 ACS interaction site; other site 767817001373 CODH interaction site; other site 767817001374 cubane metal cluster (B-cluster) [ion binding]; other site 767817001375 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 767817001376 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 767817001377 Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH)...; Region: ACS_2; cd01917 767817001378 CODH interaction site; other site 767817001379 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 767817001380 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 767817001381 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767817001382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817001383 homodimer interface [polypeptide binding]; other site 767817001384 catalytic residue [active] 767817001385 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 767817001386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767817001387 DNA-binding site [nucleotide binding]; DNA binding site 767817001388 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767817001389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817001390 homodimer interface [polypeptide binding]; other site 767817001391 catalytic residue [active] 767817001392 Protein of unknown function (DUF3680); Region: DUF3680; pfam12441 767817001393 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 767817001394 Protein of unknown function (DUF497); Region: DUF497; cl01108 767817001395 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773 767817001396 DNA binding site [nucleotide binding] 767817001397 catalytic residue [active] 767817001398 H2TH interface [polypeptide binding]; other site 767817001399 putative catalytic residues [active] 767817001400 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 767817001401 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 767817001402 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 767817001403 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 767817001404 DNA binding residues [nucleotide binding] 767817001405 dimer interface [polypeptide binding]; other site 767817001406 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 767817001407 HicB family; Region: HicB; pfam05534 767817001408 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 767817001409 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 767817001410 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 767817001411 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 767817001412 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 767817001413 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 767817001414 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767817001415 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 767817001416 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 767817001417 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 767817001418 Winged helix-turn helix; Region: HTH_29; pfam13551 767817001419 Homeodomain-like domain; Region: HTH_32; pfam13565 767817001420 Integrase core domain; Region: rve; pfam00665 767817001421 Integrase core domain; Region: rve_3; pfam13683 767817001422 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 767817001423 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 767817001424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817001425 Walker A motif; other site 767817001426 ATP binding site [chemical binding]; other site 767817001427 Walker B motif; other site 767817001428 arginine finger; other site 767817001429 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 767817001430 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817001431 active site 767817001432 DNA binding site [nucleotide binding] 767817001433 Int/Topo IB signature motif; other site 767817001434 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 767817001435 Putative transposase; Region: Y2_Tnp; pfam04986 767817001436 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767817001437 MULE transposase domain; Region: MULE; pfam10551 767817001438 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 767817001439 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817001440 active site 767817001441 DNA binding site [nucleotide binding] 767817001442 Int/Topo IB signature motif; other site 767817001443 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817001444 active site 767817001445 DNA binding site [nucleotide binding] 767817001446 Int/Topo IB signature motif; other site 767817001447 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 767817001448 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 767817001449 Int/Topo IB signature motif; other site 767817001450 HTH-like domain; Region: HTH_21; pfam13276 767817001451 Integrase core domain; Region: rve; pfam00665 767817001452 DDE domain; Region: DDE_Tnp_IS240; pfam13610 767817001453 Integrase core domain; Region: rve_3; pfam13683 767817001454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767817001455 Transposase; Region: HTH_Tnp_1; pfam01527 767817001456 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767817001457 MarR family; Region: MarR; pfam01047 767817001458 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 767817001459 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 767817001460 P loop; other site 767817001461 Nucleotide binding site [chemical binding]; other site 767817001462 DTAP/Switch II; other site 767817001463 Switch I; other site 767817001464 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 767817001465 putative dimer interface [polypeptide binding]; other site 767817001466 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 767817001467 active site 767817001468 NTP binding site [chemical binding]; other site 767817001469 metal binding triad [ion binding]; metal-binding site 767817001470 antibiotic binding site [chemical binding]; other site 767817001471 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 767817001472 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817001473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817001474 active site 767817001475 phosphorylation site [posttranslational modification] 767817001476 intermolecular recognition site; other site 767817001477 dimerization interface [polypeptide binding]; other site 767817001478 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817001479 DNA binding site [nucleotide binding] 767817001480 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817001481 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817001482 dimerization interface [polypeptide binding]; other site 767817001483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817001484 dimer interface [polypeptide binding]; other site 767817001485 phosphorylation site [posttranslational modification] 767817001486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817001487 ATP binding site [chemical binding]; other site 767817001488 Mg2+ binding site [ion binding]; other site 767817001489 G-X-G motif; other site 767817001490 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817001491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817001492 active site 767817001493 phosphorylation site [posttranslational modification] 767817001494 intermolecular recognition site; other site 767817001495 dimerization interface [polypeptide binding]; other site 767817001496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817001497 DNA binding site [nucleotide binding] 767817001498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817001499 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817001500 dimerization interface [polypeptide binding]; other site 767817001501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817001502 dimer interface [polypeptide binding]; other site 767817001503 phosphorylation site [posttranslational modification] 767817001504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817001505 ATP binding site [chemical binding]; other site 767817001506 Mg2+ binding site [ion binding]; other site 767817001507 G-X-G motif; other site 767817001508 H+ Antiporter protein; Region: 2A0121; TIGR00900 767817001509 MSEP-CTERM protein; Region: MSEP-CTERM; TIGR04286 767817001510 exosortase K; Region: exosort_XrtK; TIGR04287 767817001511 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817001512 salt bridge; other site 767817001513 non-specific DNA binding site [nucleotide binding]; other site 767817001514 sequence-specific DNA binding site [nucleotide binding]; other site 767817001515 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 767817001516 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 767817001517 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 767817001518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 767817001519 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 767817001520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 767817001521 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 767817001522 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 767817001523 putative active site [active] 767817001524 argininosuccinate lyase; Provisional; Region: PRK00855 767817001525 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 767817001526 active sites [active] 767817001527 tetramer interface [polypeptide binding]; other site 767817001528 Protein of unknown function (DUF445); Region: DUF445; pfam04286 767817001529 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 767817001530 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 767817001531 homodimer interface [polypeptide binding]; other site 767817001532 substrate-cofactor binding pocket; other site 767817001533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817001534 catalytic residue [active] 767817001535 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 767817001536 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 767817001537 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 767817001538 PYR/PP interface [polypeptide binding]; other site 767817001539 dimer interface [polypeptide binding]; other site 767817001540 TPP binding site [chemical binding]; other site 767817001541 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 767817001542 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 767817001543 TPP-binding site [chemical binding]; other site 767817001544 dimer interface [polypeptide binding]; other site 767817001545 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 767817001546 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 767817001547 putative valine binding site [chemical binding]; other site 767817001548 dimer interface [polypeptide binding]; other site 767817001549 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 767817001550 ketol-acid reductoisomerase; Provisional; Region: PRK05479 767817001551 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 767817001552 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 767817001553 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 767817001554 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 767817001555 PYR/PP interface [polypeptide binding]; other site 767817001556 dimer interface [polypeptide binding]; other site 767817001557 TPP binding site [chemical binding]; other site 767817001558 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 767817001559 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 767817001560 TPP-binding site [chemical binding]; other site 767817001561 dimer interface [polypeptide binding]; other site 767817001562 2-isopropylmalate synthase; Validated; Region: PRK00915 767817001563 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 767817001564 active site 767817001565 catalytic residues [active] 767817001566 metal binding site [ion binding]; metal-binding site 767817001567 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 767817001568 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 767817001569 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 767817001570 substrate binding site [chemical binding]; other site 767817001571 ligand binding site [chemical binding]; other site 767817001572 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 767817001573 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 767817001574 substrate binding site [chemical binding]; other site 767817001575 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 767817001576 tartrate dehydrogenase; Region: TTC; TIGR02089 767817001577 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 767817001578 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 767817001579 active site 767817001580 catalytic residues [active] 767817001581 metal binding site [ion binding]; metal-binding site 767817001582 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 767817001583 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 767817001584 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 767817001585 Ligand Binding Site [chemical binding]; other site 767817001586 Uncharacterized conserved protein [Function unknown]; Region: COG1624 767817001587 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 767817001588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 767817001589 YbbR-like protein; Region: YbbR; pfam07949 767817001590 AAA domain; Region: AAA_31; pfam13614 767817001591 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 767817001592 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 767817001593 active site 767817001594 metal binding site [ion binding]; metal-binding site 767817001595 DNA binding site [nucleotide binding] 767817001596 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767817001597 AAA domain; Region: AAA_23; pfam13476 767817001598 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 767817001599 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 767817001600 active site 767817001601 substrate binding site [chemical binding]; other site 767817001602 metal binding site [ion binding]; metal-binding site 767817001603 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 767817001604 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 767817001605 glutaminase active site [active] 767817001606 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 767817001607 dimer interface [polypeptide binding]; other site 767817001608 active site 767817001609 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 767817001610 dimer interface [polypeptide binding]; other site 767817001611 active site 767817001612 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 767817001613 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 767817001614 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 767817001615 putative [Fe4-S4] binding site [ion binding]; other site 767817001616 putative molybdopterin cofactor binding site [chemical binding]; other site 767817001617 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 767817001618 putative molybdopterin cofactor binding site; other site 767817001619 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 767817001620 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 767817001621 putative [Fe4-S4] binding site [ion binding]; other site 767817001622 putative molybdopterin cofactor binding site [chemical binding]; other site 767817001623 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 767817001624 putative molybdopterin cofactor binding site; other site 767817001625 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 767817001626 GAF domain; Region: GAF; pfam01590 767817001627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817001628 putative active site [active] 767817001629 heme pocket [chemical binding]; other site 767817001630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817001631 Walker A motif; other site 767817001632 ATP binding site [chemical binding]; other site 767817001633 Walker B motif; other site 767817001634 arginine finger; other site 767817001635 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817001636 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767817001637 MULE transposase domain; Region: MULE; pfam10551 767817001638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817001639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817001640 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 767817001641 ABC1 family; Region: ABC1; cl17513 767817001642 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 767817001643 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 767817001644 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 767817001645 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 767817001646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817001647 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 767817001648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817001649 FeS/SAM binding site; other site 767817001650 EDD domain protein, DegV family; Region: DegV; TIGR00762 767817001651 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767817001652 Predicted membrane protein [Function unknown]; Region: COG4905 767817001653 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 767817001654 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 767817001655 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817001656 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 767817001657 putative active site [active] 767817001658 heme pocket [chemical binding]; other site 767817001659 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817001660 putative active site [active] 767817001661 heme pocket [chemical binding]; other site 767817001662 PAS domain; Region: PAS_9; pfam13426 767817001663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817001664 putative active site [active] 767817001665 heme pocket [chemical binding]; other site 767817001666 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 767817001667 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817001668 putative active site [active] 767817001669 heme pocket [chemical binding]; other site 767817001670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817001671 dimer interface [polypeptide binding]; other site 767817001672 phosphorylation site [posttranslational modification] 767817001673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817001674 ATP binding site [chemical binding]; other site 767817001675 Mg2+ binding site [ion binding]; other site 767817001676 G-X-G motif; other site 767817001677 GEMM cis-regulatory element; Desgi_0631; IMG reference gene:2508511596 767817001678 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 767817001679 GAF domain; Region: GAF_2; pfam13185 767817001680 GAF domain; Region: GAF_3; pfam13492 767817001681 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 767817001682 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 767817001683 metal binding site [ion binding]; metal-binding site 767817001684 active site 767817001685 I-site; other site 767817001686 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 767817001687 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 767817001688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817001689 ATP binding site [chemical binding]; other site 767817001690 Mg2+ binding site [ion binding]; other site 767817001691 G-X-G motif; other site 767817001692 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 767817001693 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 767817001694 Transposase [DNA replication, recombination, and repair]; Region: COG5421 767817001695 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 767817001696 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 767817001697 active site residue [active] 767817001698 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 767817001699 active site residue [active] 767817001700 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817001701 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 767817001702 putative active site [active] 767817001703 catalytic site [active] 767817001704 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 767817001705 PLD-like domain; Region: PLDc_2; pfam13091 767817001706 putative active site [active] 767817001707 catalytic site [active] 767817001708 Activator of aromatic catabolism; Region: XylR_N; pfam06505 767817001709 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 767817001710 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 767817001711 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 767817001712 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 767817001713 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 767817001714 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 767817001715 DUF35 OB-fold domain; Region: DUF35; pfam01796 767817001716 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 767817001717 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 767817001718 active site 767817001719 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 767817001720 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 767817001721 NAD(P) binding site [chemical binding]; other site 767817001722 homotetramer interface [polypeptide binding]; other site 767817001723 homodimer interface [polypeptide binding]; other site 767817001724 active site 767817001725 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 767817001726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767817001727 NAD(P) binding site [chemical binding]; other site 767817001728 active site 767817001729 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 767817001730 CoA-transferase family III; Region: CoA_transf_3; pfam02515 767817001731 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 767817001732 CoA-transferase family III; Region: CoA_transf_3; pfam02515 767817001733 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767817001734 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 767817001735 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 767817001736 active site 767817001737 enoyl-CoA hydratase; Provisional; Region: PRK06494 767817001738 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817001739 substrate binding site [chemical binding]; other site 767817001740 oxyanion hole (OAH) forming residues; other site 767817001741 trimer interface [polypeptide binding]; other site 767817001742 BssC/TutF protein; Region: BssC_TutF; pfam08201 767817001743 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 767817001744 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 767817001745 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 767817001746 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 767817001747 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 767817001748 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817001749 Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236 767817001750 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767817001751 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 767817001752 Walker A motif; other site 767817001753 ATP binding site [chemical binding]; other site 767817001754 Walker B motif; other site 767817001755 arginine finger; other site 767817001756 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 767817001757 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 767817001758 metal ion-dependent adhesion site (MIDAS); other site 767817001759 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 767817001760 Propionate catabolism activator; Region: PrpR_N; pfam06506 767817001761 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 767817001762 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817001763 putative active site [active] 767817001764 heme pocket [chemical binding]; other site 767817001765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817001766 Walker A motif; other site 767817001767 ATP binding site [chemical binding]; other site 767817001768 Walker B motif; other site 767817001769 arginine finger; other site 767817001770 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817001771 BssC/TutF protein; Region: BssC_TutF; pfam08201 767817001772 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 767817001773 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 767817001774 dimer interface [polypeptide binding]; other site 767817001775 active site 767817001776 glycine loop; other site 767817001777 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 767817001778 Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236 767817001779 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 767817001780 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 767817001781 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 767817001782 metal ion-dependent adhesion site (MIDAS); other site 767817001783 [benzylsuccinate synthase]-activating enzyme; Region: rSAM_BssD; TIGR04003 767817001784 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 767817001785 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817001786 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817001787 FeS/SAM binding site; other site 767817001788 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 767817001789 DUF35 OB-fold domain; Region: DUF35; pfam01796 767817001790 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 767817001791 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 767817001792 active site 767817001793 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 767817001794 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 767817001795 NAD(P) binding site [chemical binding]; other site 767817001796 homotetramer interface [polypeptide binding]; other site 767817001797 homodimer interface [polypeptide binding]; other site 767817001798 active site 767817001799 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 767817001800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767817001801 NAD(P) binding site [chemical binding]; other site 767817001802 active site 767817001803 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 767817001804 CoA-transferase family III; Region: CoA_transf_3; pfam02515 767817001805 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 767817001806 CoA-transferase family III; Region: CoA_transf_3; pfam02515 767817001807 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767817001808 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 767817001809 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 767817001810 active site 767817001811 enoyl-CoA hydratase; Provisional; Region: PRK06494 767817001812 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817001813 substrate binding site [chemical binding]; other site 767817001814 oxyanion hole (OAH) forming residues; other site 767817001815 trimer interface [polypeptide binding]; other site 767817001816 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 767817001817 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817001818 putative active site [active] 767817001819 heme pocket [chemical binding]; other site 767817001820 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817001821 putative active site [active] 767817001822 heme pocket [chemical binding]; other site 767817001823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817001824 Walker A motif; other site 767817001825 ATP binding site [chemical binding]; other site 767817001826 Walker B motif; other site 767817001827 arginine finger; other site 767817001828 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817001829 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 767817001830 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 767817001831 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 767817001832 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 767817001833 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 767817001834 substrate binding pocket [chemical binding]; other site 767817001835 dimer interface [polypeptide binding]; other site 767817001836 inhibitor binding site; inhibition site 767817001837 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 767817001838 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 767817001839 B12 binding site [chemical binding]; other site 767817001840 CmuA_CmuC_like: uncharacterized protein family similar to uroporphyrinogen decarboxylase (URO-D) and the methyltransferases CmuA and CmuC; Region: CmuA_CmuC_like; cd03308 767817001841 CmuA_CmuC_like: uncharacterized protein family similar to uroporphyrinogen decarboxylase (URO-D) and the methyltransferases CmuA and CmuC; Region: CmuA_CmuC_like; cd03308 767817001842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767817001843 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767817001844 putative substrate translocation pore; other site 767817001845 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 767817001846 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 767817001847 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 767817001848 B12 binding site [chemical binding]; other site 767817001849 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767817001850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767817001851 DNA-binding site [nucleotide binding]; DNA binding site 767817001852 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 767817001853 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817001854 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 767817001855 catalytic loop [active] 767817001856 iron binding site [ion binding]; other site 767817001857 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 767817001858 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767817001859 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 767817001860 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 767817001861 intersubunit interface [polypeptide binding]; other site 767817001862 S-layer homology domain; Region: SLH; pfam00395 767817001863 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 767817001864 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 767817001865 active site 767817001866 C-terminal domain interface [polypeptide binding]; other site 767817001867 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 767817001868 active site 767817001869 N-terminal domain interface [polypeptide binding]; other site 767817001870 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 767817001871 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 767817001872 Walker A/P-loop; other site 767817001873 ATP binding site [chemical binding]; other site 767817001874 Q-loop/lid; other site 767817001875 ABC transporter signature motif; other site 767817001876 Walker B; other site 767817001877 D-loop; other site 767817001878 H-loop/switch region; other site 767817001879 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 767817001880 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 767817001881 ABC-ATPase subunit interface; other site 767817001882 dimer interface [polypeptide binding]; other site 767817001883 putative PBP binding regions; other site 767817001884 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 767817001885 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 767817001886 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 767817001887 DctM-like transporters; Region: DctM; pfam06808 767817001888 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 767817001889 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 767817001890 Transcriptional regulators [Transcription]; Region: GntR; COG1802 767817001891 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767817001892 DNA-binding site [nucleotide binding]; DNA binding site 767817001893 FCD domain; Region: FCD; pfam07729 767817001894 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 767817001895 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 767817001896 active site 767817001897 NAD binding site [chemical binding]; other site 767817001898 metal binding site [ion binding]; metal-binding site 767817001899 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 767817001900 MgtE intracellular N domain; Region: MgtE_N; pfam03448 767817001901 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 767817001902 Divalent cation transporter; Region: MgtE; pfam01769 767817001903 Domain of unknown function (DUF955); Region: DUF955; cl01076 767817001904 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817001905 non-specific DNA binding site [nucleotide binding]; other site 767817001906 salt bridge; other site 767817001907 sequence-specific DNA binding site [nucleotide binding]; other site 767817001908 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767817001909 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 767817001910 DNA binding residues [nucleotide binding] 767817001911 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 767817001912 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 767817001913 YvrJ protein family; Region: YvrJ; pfam12841 767817001914 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 767817001915 amidase catalytic site [active] 767817001916 Zn binding residues [ion binding]; other site 767817001917 substrate binding site [chemical binding]; other site 767817001918 Sporulation related domain; Region: SPOR; pfam05036 767817001919 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 767817001920 active site 767817001921 catalytic triad [active] 767817001922 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 767817001923 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 767817001924 Catalytic site [active] 767817001925 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 767817001926 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 767817001927 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767817001928 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767817001929 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 767817001930 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767817001931 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767817001932 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 767817001933 IMP binding site; other site 767817001934 dimer interface [polypeptide binding]; other site 767817001935 partial ornithine binding site; other site 767817001936 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 767817001937 Uncharacterized conserved protein [Function unknown]; Region: COG2128 767817001938 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817001939 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 767817001940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817001941 dimer interface [polypeptide binding]; other site 767817001942 phosphorylation site [posttranslational modification] 767817001943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817001944 ATP binding site [chemical binding]; other site 767817001945 Mg2+ binding site [ion binding]; other site 767817001946 G-X-G motif; other site 767817001947 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 767817001948 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 767817001949 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 767817001950 Walker A motif; other site 767817001951 ATP binding site [chemical binding]; other site 767817001952 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 767817001953 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 767817001954 Walker A motif; other site 767817001955 Walker A motif; other site 767817001956 ATP binding site [chemical binding]; other site 767817001957 Walker B motif; other site 767817001958 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 767817001959 Walker A motif; other site 767817001960 ATP binding site [chemical binding]; other site 767817001961 Walker B motif; other site 767817001962 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 767817001963 dinuclear metal binding motif [ion binding]; other site 767817001964 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 767817001965 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 767817001966 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 767817001967 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 767817001968 Multicopper oxidase; Region: Cu-oxidase; pfam00394 767817001969 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 767817001970 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 767817001971 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 767817001972 Multicopper oxidase; Region: Cu-oxidase; pfam00394 767817001973 Protein of unknown function DUF89; Region: DUF89; cl15397 767817001974 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817001975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817001976 active site 767817001977 phosphorylation site [posttranslational modification] 767817001978 intermolecular recognition site; other site 767817001979 dimerization interface [polypeptide binding]; other site 767817001980 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817001981 DNA binding site [nucleotide binding] 767817001982 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817001983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817001984 dimer interface [polypeptide binding]; other site 767817001985 phosphorylation site [posttranslational modification] 767817001986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817001987 ATP binding site [chemical binding]; other site 767817001988 Mg2+ binding site [ion binding]; other site 767817001989 G-X-G motif; other site 767817001990 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 767817001991 septation ring formation regulator EzrA; Provisional; Region: PRK04778 767817001992 cobalt transport protein CbiM; Validated; Region: PRK06265 767817001993 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 767817001994 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 767817001995 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767817001996 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767817001997 Walker A/P-loop; other site 767817001998 ATP binding site [chemical binding]; other site 767817001999 Q-loop/lid; other site 767817002000 ABC transporter signature motif; other site 767817002001 Walker B; other site 767817002002 D-loop; other site 767817002003 H-loop/switch region; other site 767817002004 2-isopropylmalate synthase; Validated; Region: PRK00915 767817002005 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 767817002006 active site 767817002007 catalytic residues [active] 767817002008 metal binding site [ion binding]; metal-binding site 767817002009 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 767817002010 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 767817002011 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 767817002012 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 767817002013 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817002014 acyl-activating enzyme (AAE) consensus motif; other site 767817002015 AMP binding site [chemical binding]; other site 767817002016 active site 767817002017 CoA binding site [chemical binding]; other site 767817002018 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 767817002019 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 767817002020 tetramer interface [polypeptide binding]; other site 767817002021 TPP-binding site [chemical binding]; other site 767817002022 heterodimer interface [polypeptide binding]; other site 767817002023 phosphorylation loop region [posttranslational modification] 767817002024 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 767817002025 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 767817002026 alpha subunit interface [polypeptide binding]; other site 767817002027 TPP binding site [chemical binding]; other site 767817002028 heterodimer interface [polypeptide binding]; other site 767817002029 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767817002030 competence damage-inducible protein A; Provisional; Region: PRK00549 767817002031 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 767817002032 putative MPT binding site; other site 767817002033 Competence-damaged protein; Region: CinA; cl00666 767817002034 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767817002035 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767817002036 Probable transposase; Region: OrfB_IS605; pfam01385 767817002037 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 767817002038 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 767817002039 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 767817002040 putative dimer interface [polypeptide binding]; other site 767817002041 putative anticodon binding site; other site 767817002042 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 767817002043 homodimer interface [polypeptide binding]; other site 767817002044 motif 1; other site 767817002045 motif 2; other site 767817002046 active site 767817002047 motif 3; other site 767817002048 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 767817002049 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 767817002050 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 767817002051 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 767817002052 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 767817002053 dimer interface [polypeptide binding]; other site 767817002054 PYR/PP interface [polypeptide binding]; other site 767817002055 TPP binding site [chemical binding]; other site 767817002056 substrate binding site [chemical binding]; other site 767817002057 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 767817002058 TPP-binding site [chemical binding]; other site 767817002059 4Fe-4S binding domain; Region: Fer4; pfam00037 767817002060 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 767817002061 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 767817002062 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 767817002063 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 767817002064 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 767817002065 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 767817002066 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 767817002067 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817002068 catalytic loop [active] 767817002069 iron binding site [ion binding]; other site 767817002070 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 767817002071 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 767817002072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817002073 Walker A motif; other site 767817002074 ATP binding site [chemical binding]; other site 767817002075 Walker B motif; other site 767817002076 arginine finger; other site 767817002077 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 767817002078 metal ion-dependent adhesion site (MIDAS); other site 767817002079 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 767817002080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 767817002081 Walker A motif; other site 767817002082 ATP binding site [chemical binding]; other site 767817002083 Walker B motif; other site 767817002084 arginine finger; other site 767817002085 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767817002086 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 767817002087 MOSC domain; Region: MOSC; pfam03473 767817002088 macrolide transporter subunit MacA; Provisional; Region: PRK11578 767817002089 PBP superfamily domain; Region: PBP_like_2; pfam12849 767817002090 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 767817002091 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 767817002092 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 767817002093 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 767817002094 flavoprotein, HI0933 family; Region: TIGR00275 767817002095 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767817002096 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 767817002097 4Fe-4S binding domain; Region: Fer4; cl02805 767817002098 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 767817002099 CAAX protease self-immunity; Region: Abi; pfam02517 767817002100 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817002101 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 767817002102 active site 767817002103 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 767817002104 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817002105 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 767817002106 DNA-binding site [nucleotide binding]; DNA binding site 767817002107 RNA-binding motif; other site 767817002108 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 767817002109 putative active site pocket [active] 767817002110 dimerization interface [polypeptide binding]; other site 767817002111 putative catalytic residue [active] 767817002112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767817002113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767817002114 putative substrate translocation pore; other site 767817002115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767817002116 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 767817002117 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 767817002118 HPP family; Region: HPP; pfam04982 767817002119 Cupin domain; Region: Cupin_2; pfam07883 767817002120 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 767817002121 putative homodimer interface [polypeptide binding]; other site 767817002122 putative homotetramer interface [polypeptide binding]; other site 767817002123 putative allosteric switch controlling residues; other site 767817002124 putative metal binding site [ion binding]; other site 767817002125 putative homodimer-homodimer interface [polypeptide binding]; other site 767817002126 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 767817002127 CPxP motif; other site 767817002128 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 767817002129 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817002130 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 767817002131 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 767817002132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817002133 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817002134 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817002135 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 767817002136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817002137 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817002138 4Fe-4S binding domain; Region: Fer4; pfam00037 767817002139 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 767817002140 putative Zn2+ binding site [ion binding]; other site 767817002141 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 767817002142 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767817002143 Cysteine-rich domain; Region: CCG; pfam02754 767817002144 Cysteine-rich domain; Region: CCG; pfam02754 767817002145 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 767817002146 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 767817002147 intersubunit interface [polypeptide binding]; other site 767817002148 active site 767817002149 catalytic residue [active] 767817002150 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 767817002151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767817002152 motif II; other site 767817002153 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 767817002154 putative deacylase active site [active] 767817002155 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 767817002156 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 767817002157 metal-binding site [ion binding] 767817002158 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 767817002159 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 767817002160 metal-binding site [ion binding] 767817002161 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767817002162 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767817002163 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 767817002164 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 767817002165 CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881 767817002166 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 767817002167 Family of unknown function (DUF694); Region: DUF694; pfam05107 767817002168 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 767817002169 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 767817002170 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767817002171 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 767817002172 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 767817002173 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 767817002174 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 767817002175 Predicted transporter (DUF2162); Region: DUF2162; cl01990 767817002176 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 767817002177 Uncharacterized conserved protein (DUF2149); Region: DUF2149; cl01960 767817002178 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 767817002179 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]; Region: CobN; COG1429 767817002180 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 767817002181 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767817002182 MULE transposase domain; Region: MULE; pfam10551 767817002183 Transposase [DNA replication, recombination, and repair]; Region: COG5421 767817002184 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 767817002185 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 767817002186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817002187 S-adenosylmethionine binding site [chemical binding]; other site 767817002188 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 767817002189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817002190 dimer interface [polypeptide binding]; other site 767817002191 conserved gate region; other site 767817002192 putative PBP binding loops; other site 767817002193 ABC-ATPase subunit interface; other site 767817002194 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 767817002195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817002196 dimer interface [polypeptide binding]; other site 767817002197 conserved gate region; other site 767817002198 putative PBP binding loops; other site 767817002199 ABC-ATPase subunit interface; other site 767817002200 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 767817002201 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 767817002202 Walker A/P-loop; other site 767817002203 ATP binding site [chemical binding]; other site 767817002204 Q-loop/lid; other site 767817002205 ABC transporter signature motif; other site 767817002206 Walker B; other site 767817002207 D-loop; other site 767817002208 H-loop/switch region; other site 767817002209 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 767817002210 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 767817002211 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 767817002212 Walker A/P-loop; other site 767817002213 ATP binding site [chemical binding]; other site 767817002214 Q-loop/lid; other site 767817002215 ABC transporter signature motif; other site 767817002216 Walker B; other site 767817002217 D-loop; other site 767817002218 H-loop/switch region; other site 767817002219 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 767817002220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817002221 S-adenosylmethionine binding site [chemical binding]; other site 767817002222 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 767817002223 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 767817002224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817002225 S-adenosylmethionine binding site [chemical binding]; other site 767817002226 RelB antitoxin; Region: RelB; cl01171 767817002227 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 767817002228 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 767817002229 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 767817002230 P-loop; other site 767817002231 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 767817002232 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 767817002233 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 767817002234 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 767817002235 putative active site [active] 767817002236 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 767817002237 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 767817002238 RNA polymerase factor sigma-70; Validated; Region: PRK06811 767817002239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817002240 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 767817002241 S-layer homology domain; Region: SLH; pfam00395 767817002242 MarR family; Region: MarR_2; cl17246 767817002243 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 767817002244 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767817002245 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 767817002246 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 767817002247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817002248 Walker A/P-loop; other site 767817002249 ATP binding site [chemical binding]; other site 767817002250 Q-loop/lid; other site 767817002251 ABC transporter signature motif; other site 767817002252 Walker B; other site 767817002253 D-loop; other site 767817002254 H-loop/switch region; other site 767817002255 TOBE domain; Region: TOBE_2; pfam08402 767817002256 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 767817002257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817002258 dimer interface [polypeptide binding]; other site 767817002259 conserved gate region; other site 767817002260 putative PBP binding loops; other site 767817002261 ABC-ATPase subunit interface; other site 767817002262 molybdate ABC transporter periplasmic substrate-binding protein; Provisional; Region: PRK04168 767817002263 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 767817002264 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 767817002265 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 767817002266 Walker A/P-loop; other site 767817002267 ATP binding site [chemical binding]; other site 767817002268 Q-loop/lid; other site 767817002269 ABC transporter signature motif; other site 767817002270 Walker B; other site 767817002271 D-loop; other site 767817002272 H-loop/switch region; other site 767817002273 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 767817002274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817002275 dimer interface [polypeptide binding]; other site 767817002276 conserved gate region; other site 767817002277 putative PBP binding loops; other site 767817002278 ABC-ATPase subunit interface; other site 767817002279 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 767817002280 NMT1-like family; Region: NMT1_2; pfam13379 767817002281 Domain of unknown function (DUF364); Region: DUF364; pfam04016 767817002282 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 767817002283 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 767817002284 Nitrogen regulatory protein P-II; Region: P-II; smart00938 767817002285 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 767817002286 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 767817002287 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 767817002288 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 767817002289 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 767817002290 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767817002291 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 767817002292 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817002293 ATP binding site [chemical binding]; other site 767817002294 putative Mg++ binding site [ion binding]; other site 767817002295 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817002296 nucleotide binding region [chemical binding]; other site 767817002297 ATP-binding site [chemical binding]; other site 767817002298 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 767817002299 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 767817002300 thiS-thiF/thiG interaction site; other site 767817002301 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 767817002302 ThiS interaction site; other site 767817002303 putative active site [active] 767817002304 tetramer interface [polypeptide binding]; other site 767817002305 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 767817002306 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817002307 FeS/SAM binding site; other site 767817002308 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 767817002309 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 767817002310 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 767817002311 ATP binding site [chemical binding]; other site 767817002312 substrate interface [chemical binding]; other site 767817002313 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 767817002314 thiamine phosphate binding site [chemical binding]; other site 767817002315 active site 767817002316 pyrophosphate binding site [ion binding]; other site 767817002317 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 767817002318 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 767817002319 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 767817002320 HicB family; Region: HicB; pfam05534 767817002321 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767817002322 active site 767817002323 uracil transporter; Provisional; Region: PRK10720 767817002324 Peptidase family M48; Region: Peptidase_M48; pfam01435 767817002325 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 767817002326 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 767817002327 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576 767817002328 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 767817002329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767817002330 NAD(P) binding site [chemical binding]; other site 767817002331 active site 767817002332 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 767817002333 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 767817002334 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 767817002335 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 767817002336 HlyD family secretion protein; Region: HlyD_3; pfam13437 767817002337 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767817002338 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767817002339 Walker A/P-loop; other site 767817002340 ATP binding site [chemical binding]; other site 767817002341 Q-loop/lid; other site 767817002342 ABC transporter signature motif; other site 767817002343 Walker B; other site 767817002344 D-loop; other site 767817002345 H-loop/switch region; other site 767817002346 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 767817002347 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767817002348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817002349 Walker A/P-loop; other site 767817002350 ATP binding site [chemical binding]; other site 767817002351 Q-loop/lid; other site 767817002352 ABC transporter signature motif; other site 767817002353 Walker B; other site 767817002354 D-loop; other site 767817002355 H-loop/switch region; other site 767817002356 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 767817002357 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 767817002358 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 767817002359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817002360 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817002361 Coat F domain; Region: Coat_F; pfam07875 767817002362 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767817002363 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 767817002364 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 767817002365 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 767817002366 Glyco_18 domain; Region: Glyco_18; smart00636 767817002367 active site 767817002368 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 767817002369 AIR carboxylase; Region: AIRC; smart01001 767817002370 XcyI restriction endonuclease; Region: RE_XcyI; pfam09571 767817002371 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 767817002372 DNA methylase; Region: N6_N4_Mtase; pfam01555 767817002373 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 767817002374 Mechanosensitive ion channel; Region: MS_channel; pfam00924 767817002375 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 767817002376 BON domain; Region: BON; pfam04972 767817002377 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 767817002378 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 767817002379 putative catalytic cysteine [active] 767817002380 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 767817002381 putative active site [active] 767817002382 metal binding site [ion binding]; metal-binding site 767817002383 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767817002384 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 767817002385 diiron binding motif [ion binding]; other site 767817002386 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 767817002387 metal-binding site [ion binding] 767817002388 FOG: CBS domain [General function prediction only]; Region: COG0517 767817002389 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 767817002390 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 767817002391 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817002392 putative active site [active] 767817002393 heme pocket [chemical binding]; other site 767817002394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817002395 putative active site [active] 767817002396 heme pocket [chemical binding]; other site 767817002397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817002398 Walker A motif; other site 767817002399 ATP binding site [chemical binding]; other site 767817002400 Walker B motif; other site 767817002401 arginine finger; other site 767817002402 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 767817002403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817002404 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 767817002405 putative active site [active] 767817002406 heme pocket [chemical binding]; other site 767817002407 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 767817002408 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817002409 putative active site [active] 767817002410 heme pocket [chemical binding]; other site 767817002411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817002412 dimer interface [polypeptide binding]; other site 767817002413 phosphorylation site [posttranslational modification] 767817002414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817002415 ATP binding site [chemical binding]; other site 767817002416 Mg2+ binding site [ion binding]; other site 767817002417 G-X-G motif; other site 767817002418 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 767817002419 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 767817002420 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 767817002421 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 767817002422 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 767817002423 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 767817002424 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 767817002425 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 767817002426 homodimer interaction site [polypeptide binding]; other site 767817002427 cofactor binding site; other site 767817002428 Protein containing a metal-binding domain shared with formylmethanofuran dehydrogenase subunit E [General function prediction only]; Region: COG5643 767817002429 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 767817002430 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_21; cd08520 767817002431 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 767817002432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817002433 dimer interface [polypeptide binding]; other site 767817002434 conserved gate region; other site 767817002435 putative PBP binding loops; other site 767817002436 ABC-ATPase subunit interface; other site 767817002437 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 767817002438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817002439 ABC-ATPase subunit interface; other site 767817002440 putative PBP binding loops; other site 767817002441 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 767817002442 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 767817002443 Walker A/P-loop; other site 767817002444 ATP binding site [chemical binding]; other site 767817002445 Q-loop/lid; other site 767817002446 ABC transporter signature motif; other site 767817002447 Walker B; other site 767817002448 D-loop; other site 767817002449 H-loop/switch region; other site 767817002450 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 767817002451 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 767817002452 Walker A/P-loop; other site 767817002453 ATP binding site [chemical binding]; other site 767817002454 Q-loop/lid; other site 767817002455 ABC transporter signature motif; other site 767817002456 Walker B; other site 767817002457 D-loop; other site 767817002458 H-loop/switch region; other site 767817002459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817002460 H-loop/switch region; other site 767817002461 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 767817002462 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 767817002463 biotin synthase; Provisional; Region: PRK07094 767817002464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817002465 FeS/SAM binding site; other site 767817002466 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 767817002467 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 767817002468 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 767817002469 G1 box; other site 767817002470 GTP/Mg2+ binding site [chemical binding]; other site 767817002471 Switch I region; other site 767817002472 G2 box; other site 767817002473 Switch II region; other site 767817002474 G3 box; other site 767817002475 G4 box; other site 767817002476 G5 box; other site 767817002477 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 767817002478 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 767817002479 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 767817002480 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 767817002481 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 767817002482 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 767817002483 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 767817002484 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 767817002485 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767817002486 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 767817002487 transmembrane helices; other site 767817002488 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767817002489 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 767817002490 carboxyltransferase (CT) interaction site; other site 767817002491 biotinylation site [posttranslational modification]; other site 767817002492 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 767817002493 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 767817002494 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 767817002495 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 767817002496 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767817002497 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 767817002498 putative dimerization interface [polypeptide binding]; other site 767817002499 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 767817002500 4Fe-4S binding domain; Region: Fer4; pfam00037 767817002501 4Fe-4S binding domain; Region: Fer4; pfam00037 767817002502 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 767817002503 Putative Fe-S cluster; Region: FeS; cl17515 767817002504 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 767817002505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817002506 ATP binding site [chemical binding]; other site 767817002507 Mg2+ binding site [ion binding]; other site 767817002508 G-X-G motif; other site 767817002509 DRTGG domain; Region: DRTGG; pfam07085 767817002510 hypothetical protein; Provisional; Region: PRK10410 767817002511 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817002512 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 767817002513 putative active site [active] 767817002514 heme pocket [chemical binding]; other site 767817002515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817002516 dimer interface [polypeptide binding]; other site 767817002517 phosphorylation site [posttranslational modification] 767817002518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817002519 ATP binding site [chemical binding]; other site 767817002520 Mg2+ binding site [ion binding]; other site 767817002521 G-X-G motif; other site 767817002522 Staphylococcal AgrD protein; Region: AgrD; cl05477 767817002523 Accessory gene regulator B; Region: AgrB; pfam04647 767817002524 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 767817002525 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 767817002526 putative metal binding site [ion binding]; other site 767817002527 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 767817002528 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 767817002529 putative metal binding site [ion binding]; other site 767817002530 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 767817002531 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 767817002532 putative metal binding site [ion binding]; other site 767817002533 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 767817002534 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 767817002535 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 767817002536 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 767817002537 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767817002538 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 767817002539 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 767817002540 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 767817002541 putative metal binding site [ion binding]; other site 767817002542 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 767817002543 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 767817002544 putative metal binding site [ion binding]; other site 767817002545 heat shock protein 90; Provisional; Region: PRK05218 767817002546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817002547 ATP binding site [chemical binding]; other site 767817002548 Mg2+ binding site [ion binding]; other site 767817002549 G-X-G motif; other site 767817002550 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 767817002551 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 767817002552 catalytic residue [active] 767817002553 putative FPP diphosphate binding site; other site 767817002554 putative FPP binding hydrophobic cleft; other site 767817002555 dimer interface [polypeptide binding]; other site 767817002556 putative IPP diphosphate binding site; other site 767817002557 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 767817002558 dimer interface [polypeptide binding]; other site 767817002559 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 767817002560 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 767817002561 transmembrane helices; other site 767817002562 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817002563 AMIN domain; Region: AMIN; pfam11741 767817002564 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 767817002565 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 767817002566 active site 767817002567 metal binding site [ion binding]; metal-binding site 767817002568 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 767817002569 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 767817002570 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 767817002571 TIGR02679 family protein; Region: TIGR02679 767817002572 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 767817002573 TIGR02680 family protein; Region: TIGR02680 767817002574 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 767817002575 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 767817002576 TIGR02677 family protein; Region: TIGR02677 767817002577 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 767817002578 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 767817002579 active site 767817002580 NTP binding site [chemical binding]; other site 767817002581 metal binding triad [ion binding]; metal-binding site 767817002582 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 767817002583 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 767817002584 Fic family protein [Function unknown]; Region: COG3177 767817002585 Fic/DOC family; Region: Fic; pfam02661 767817002586 HEPN domain; Region: HEPN; cl00824 767817002587 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 767817002588 Predicted nucleotidyltransferases [General function prediction only]; Region: COG1708 767817002589 active site 767817002590 NTP binding site [chemical binding]; other site 767817002591 metal binding triad [ion binding]; metal-binding site 767817002592 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 767817002593 putative metal binding residues [ion binding]; other site 767817002594 signature motif; other site 767817002595 dimer interface [polypeptide binding]; other site 767817002596 active site 767817002597 polyP binding site; other site 767817002598 substrate binding site [chemical binding]; other site 767817002599 acceptor-phosphate pocket; other site 767817002600 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 767817002601 CotH protein; Region: CotH; pfam08757 767817002602 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817002603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817002604 active site 767817002605 phosphorylation site [posttranslational modification] 767817002606 intermolecular recognition site; other site 767817002607 dimerization interface [polypeptide binding]; other site 767817002608 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817002609 DNA binding site [nucleotide binding] 767817002610 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817002611 dimerization interface [polypeptide binding]; other site 767817002612 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 767817002613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817002614 dimer interface [polypeptide binding]; other site 767817002615 phosphorylation site [posttranslational modification] 767817002616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817002617 ATP binding site [chemical binding]; other site 767817002618 Mg2+ binding site [ion binding]; other site 767817002619 G-X-G motif; other site 767817002620 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 767817002621 putative active site pocket [active] 767817002622 cleavage site 767817002623 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 767817002624 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 767817002625 Nitrogen regulatory protein P-II; Region: P-II; smart00938 767817002626 Uncharacterized conserved protein [Function unknown]; Region: COG2968 767817002627 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 767817002628 Protein of unknown function (DUF867); Region: DUF867; pfam05908 767817002629 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 767817002630 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 767817002631 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767817002632 motif II; other site 767817002633 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767817002634 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817002635 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 767817002636 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 767817002637 putative active site [active] 767817002638 metal binding site [ion binding]; metal-binding site 767817002639 PAS domain S-box; Region: sensory_box; TIGR00229 767817002640 PAS domain; Region: PAS; smart00091 767817002641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817002642 putative active site [active] 767817002643 heme pocket [chemical binding]; other site 767817002644 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817002645 dimer interface [polypeptide binding]; other site 767817002646 phosphorylation site [posttranslational modification] 767817002647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817002648 ATP binding site [chemical binding]; other site 767817002649 Mg2+ binding site [ion binding]; other site 767817002650 G-X-G motif; other site 767817002651 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 767817002652 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 767817002653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817002654 ATP binding site [chemical binding]; other site 767817002655 putative Mg++ binding site [ion binding]; other site 767817002656 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 767817002657 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 767817002658 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767817002659 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767817002660 KilA-N domain; Region: KilA-N; pfam04383 767817002661 HsdM N-terminal domain; Region: HsdM_N; pfam12161 767817002662 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 767817002663 Methyltransferase domain; Region: Methyltransf_26; pfam13659 767817002664 A new structural DNA glycosylase; Region: AlkD_like; cd06561 767817002665 active site 767817002666 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 767817002667 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817002668 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817002669 DNA binding residues [nucleotide binding] 767817002670 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 767817002671 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 767817002672 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 767817002673 TAP-like protein; Region: Abhydrolase_4; pfam08386 767817002674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817002675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817002676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817002677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817002678 phosphoenolpyruvate synthase; Validated; Region: PRK06241 767817002679 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 767817002680 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 767817002681 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767817002682 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767817002683 Probable transposase; Region: OrfB_IS605; pfam01385 767817002684 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 767817002685 catalytic motif [active] 767817002686 Catalytic residue [active] 767817002687 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 767817002688 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 767817002689 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 767817002690 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 767817002691 Catalytic dyad [active] 767817002692 Methyltransferase domain; Region: Methyltransf_31; pfam13847 767817002693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817002694 S-adenosylmethionine binding site [chemical binding]; other site 767817002695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767817002696 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767817002697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767817002698 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 767817002699 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 767817002700 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 767817002701 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 767817002702 active site 767817002703 PHP Thumb interface [polypeptide binding]; other site 767817002704 metal binding site [ion binding]; metal-binding site 767817002705 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 767817002706 generic binding surface II; other site 767817002707 generic binding surface I; other site 767817002708 Protein of unknown function DUF72; Region: DUF72; pfam01904 767817002709 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 767817002710 Fe-S cluster binding site [ion binding]; other site 767817002711 active site 767817002712 translocation protein TolB; Provisional; Region: tolB; PRK01742 767817002713 translocation protein TolB; Provisional; Region: tolB; PRK05137 767817002714 translocation protein TolB; Provisional; Region: tolB; PRK04922 767817002715 Helix-turn-helix domain; Region: HTH_17; pfam12728 767817002716 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817002717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817002718 active site 767817002719 phosphorylation site [posttranslational modification] 767817002720 intermolecular recognition site; other site 767817002721 dimerization interface [polypeptide binding]; other site 767817002722 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817002723 DNA binding site [nucleotide binding] 767817002724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817002725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817002726 dimer interface [polypeptide binding]; other site 767817002727 phosphorylation site [posttranslational modification] 767817002728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817002729 ATP binding site [chemical binding]; other site 767817002730 Mg2+ binding site [ion binding]; other site 767817002731 G-X-G motif; other site 767817002732 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767817002733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817002734 Walker A/P-loop; other site 767817002735 ATP binding site [chemical binding]; other site 767817002736 Q-loop/lid; other site 767817002737 ABC transporter signature motif; other site 767817002738 Walker B; other site 767817002739 D-loop; other site 767817002740 H-loop/switch region; other site 767817002741 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 767817002742 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 767817002743 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 767817002744 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 767817002745 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 767817002746 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 767817002747 putative active site [active] 767817002748 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 767817002749 biotin synthase; Region: bioB; TIGR00433 767817002750 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817002751 FeS/SAM binding site; other site 767817002752 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 767817002753 AAA domain; Region: AAA_26; pfam13500 767817002754 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 767817002755 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 767817002756 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 767817002757 inhibitor-cofactor binding pocket; inhibition site 767817002758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817002759 catalytic residue [active] 767817002760 SnoaL-like domain; Region: SnoaL_3; pfam13474 767817002761 Transposase domain (DUF772); Region: DUF772; pfam05598 767817002762 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767817002763 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 767817002764 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767817002765 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 767817002766 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 767817002767 phosphoenolpyruvate synthase; Validated; Region: PRK06241 767817002768 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 767817002769 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 767817002770 phosphoenolpyruvate synthase; Validated; Region: PRK06241 767817002771 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 767817002772 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 767817002773 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 767817002774 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 767817002775 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 767817002776 oligomer interface [polypeptide binding]; other site 767817002777 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 767817002778 Double zinc ribbon; Region: DZR; pfam12773 767817002779 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 767817002780 Catalytic domain of Protein Kinases; Region: PKc; cd00180 767817002781 active site 767817002782 ATP binding site [chemical binding]; other site 767817002783 substrate binding site [chemical binding]; other site 767817002784 activation loop (A-loop); other site 767817002785 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 767817002786 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 767817002787 HlyD family secretion protein; Region: HlyD_3; pfam13437 767817002788 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 767817002789 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817002790 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817002791 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 767817002792 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 767817002793 B12 binding site [chemical binding]; other site 767817002794 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 767817002795 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817002796 FeS/SAM binding site; other site 767817002797 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 767817002798 Radical SAM superfamily; Region: Radical_SAM; pfam04055 767817002799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817002800 FeS/SAM binding site; other site 767817002801 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817002802 Coenzyme A binding pocket [chemical binding]; other site 767817002803 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 767817002804 putative active site [active] 767817002805 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 767817002806 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 767817002807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767817002808 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767817002809 putative substrate translocation pore; other site 767817002810 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 767817002811 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 767817002812 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 767817002813 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 767817002814 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 767817002815 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 767817002816 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 767817002817 putative active site [active] 767817002818 Helix-turn-helix domain; Region: HTH_17; pfam12728 767817002819 Cache domain; Region: Cache_1; pfam02743 767817002820 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817002821 dimerization interface [polypeptide binding]; other site 767817002822 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 767817002823 dimer interface [polypeptide binding]; other site 767817002824 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 767817002825 putative CheW interface [polypeptide binding]; other site 767817002826 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 767817002827 VanW like protein; Region: VanW; pfam04294 767817002828 G5 domain; Region: G5; pfam07501 767817002829 4Fe-4S binding domain; Region: Fer4_5; pfam12801 767817002830 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 767817002831 4Fe-4S binding domain; Region: Fer4; cl02805 767817002832 FMN reductase; Validated; Region: fre; PRK08051 767817002833 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 767817002834 FAD binding pocket [chemical binding]; other site 767817002835 conserved FAD binding motif [chemical binding]; other site 767817002836 phosphate binding motif [ion binding]; other site 767817002837 beta-alpha-beta structure motif; other site 767817002838 NAD binding pocket [chemical binding]; other site 767817002839 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 767817002840 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 767817002841 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 767817002842 dimer interface [polypeptide binding]; other site 767817002843 substrate binding site [chemical binding]; other site 767817002844 metal binding site [ion binding]; metal-binding site 767817002845 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 767817002846 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 767817002847 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 767817002848 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 767817002849 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767817002850 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767817002851 Cysteine-rich domain; Region: CCG; pfam02754 767817002852 Cysteine-rich domain; Region: CCG; pfam02754 767817002853 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817002854 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 767817002855 4Fe-4S binding domain; Region: Fer4; pfam00037 767817002856 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817002857 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817002858 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 767817002859 4Fe-4S binding domain; Region: Fer4_6; pfam12837 767817002860 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817002861 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 767817002862 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767817002863 putative DNA binding site [nucleotide binding]; other site 767817002864 putative Zn2+ binding site [ion binding]; other site 767817002865 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 767817002866 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 767817002867 putative dimer interface [polypeptide binding]; other site 767817002868 [2Fe-2S] cluster binding site [ion binding]; other site 767817002869 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 767817002870 dimer interface [polypeptide binding]; other site 767817002871 [2Fe-2S] cluster binding site [ion binding]; other site 767817002872 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 767817002873 SLBB domain; Region: SLBB; pfam10531 767817002874 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 767817002875 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817002876 catalytic loop [active] 767817002877 iron binding site [ion binding]; other site 767817002878 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767817002879 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817002880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817002881 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 767817002882 putative active site [active] 767817002883 heme pocket [chemical binding]; other site 767817002884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817002885 Walker A motif; other site 767817002886 ATP binding site [chemical binding]; other site 767817002887 Walker B motif; other site 767817002888 arginine finger; other site 767817002889 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 767817002890 PAS domain; Region: PAS_10; pfam13596 767817002891 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817002892 putative active site [active] 767817002893 heme pocket [chemical binding]; other site 767817002894 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 767817002895 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 767817002896 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 767817002897 4Fe-4S binding domain; Region: Fer4; cl02805 767817002898 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 767817002899 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 767817002900 molybdopterin cofactor binding site; other site 767817002901 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 767817002902 molybdopterin cofactor binding site; other site 767817002903 phenylhydantoinase; Validated; Region: PRK08323 767817002904 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767817002905 active site 767817002906 PAS domain S-box; Region: sensory_box; TIGR00229 767817002907 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817002908 putative active site [active] 767817002909 heme pocket [chemical binding]; other site 767817002910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817002911 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 767817002912 Walker A motif; other site 767817002913 ATP binding site [chemical binding]; other site 767817002914 Walker B motif; other site 767817002915 arginine finger; other site 767817002916 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 767817002917 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 767817002918 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817002919 4Fe-4S binding domain; Region: Fer4; pfam00037 767817002920 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 767817002921 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 767817002922 dimer interface [polypeptide binding]; other site 767817002923 PYR/PP interface [polypeptide binding]; other site 767817002924 TPP binding site [chemical binding]; other site 767817002925 substrate binding site [chemical binding]; other site 767817002926 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767817002927 2-ketoisovalerate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11864 767817002928 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 767817002929 TPP-binding site [chemical binding]; other site 767817002930 putative dimer interface [polypeptide binding]; other site 767817002931 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 767817002932 Histidine kinase; Region: HisKA_3; pfam07730 767817002933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817002934 ATP binding site [chemical binding]; other site 767817002935 Mg2+ binding site [ion binding]; other site 767817002936 G-X-G motif; other site 767817002937 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 767817002938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817002939 active site 767817002940 phosphorylation site [posttranslational modification] 767817002941 intermolecular recognition site; other site 767817002942 dimerization interface [polypeptide binding]; other site 767817002943 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 767817002944 DNA binding residues [nucleotide binding] 767817002945 dimerization interface [polypeptide binding]; other site 767817002946 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 767817002947 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 767817002948 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 767817002949 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 767817002950 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 767817002951 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 767817002952 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817002953 acyl-activating enzyme (AAE) consensus motif; other site 767817002954 AMP binding site [chemical binding]; other site 767817002955 active site 767817002956 CoA binding site [chemical binding]; other site 767817002957 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 767817002958 active site 2 [active] 767817002959 active site 1 [active] 767817002960 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 767817002961 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 767817002962 active site 767817002963 FMN binding site [chemical binding]; other site 767817002964 substrate binding site [chemical binding]; other site 767817002965 putative catalytic residue [active] 767817002966 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 767817002967 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817002968 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767817002969 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 767817002970 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 767817002971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817002972 Walker A motif; other site 767817002973 ATP binding site [chemical binding]; other site 767817002974 Walker B motif; other site 767817002975 arginine finger; other site 767817002976 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817002977 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 767817002978 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 767817002979 B12 binding site [chemical binding]; other site 767817002980 cobalt ligand [ion binding]; other site 767817002981 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 767817002982 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817002983 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 767817002984 acyl-activating enzyme (AAE) consensus motif; other site 767817002985 acyl-activating enzyme (AAE) consensus motif; other site 767817002986 putative AMP binding site [chemical binding]; other site 767817002987 putative active site [active] 767817002988 putative CoA binding site [chemical binding]; other site 767817002989 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 767817002990 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 767817002991 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 767817002992 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 767817002993 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 767817002994 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 767817002995 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 767817002996 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 767817002997 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 767817002998 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 767817002999 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 767817003000 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 767817003001 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 767817003002 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 767817003003 active site 2 [active] 767817003004 active site 1 [active] 767817003005 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 767817003006 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 767817003007 NAD(P) binding site [chemical binding]; other site 767817003008 homotetramer interface [polypeptide binding]; other site 767817003009 homodimer interface [polypeptide binding]; other site 767817003010 active site 767817003011 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 767817003012 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 767817003013 active site 767817003014 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 767817003015 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 767817003016 DUF35 OB-fold domain; Region: DUF35; pfam01796 767817003017 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767817003018 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 767817003019 active site 767817003020 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 767817003021 Nucleoside recognition; Region: Gate; pfam07670 767817003022 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 767817003023 Nucleoside recognition; Region: Gate; pfam07670 767817003024 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 767817003025 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 767817003026 G1 box; other site 767817003027 GTP/Mg2+ binding site [chemical binding]; other site 767817003028 Switch I region; other site 767817003029 G2 box; other site 767817003030 G3 box; other site 767817003031 Switch II region; other site 767817003032 G4 box; other site 767817003033 G5 box; other site 767817003034 FeoA domain; Region: FeoA; pfam04023 767817003035 manganese transport transcriptional regulator; Provisional; Region: PRK03902 767817003036 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 767817003037 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 767817003038 Response regulator receiver domain; Region: Response_reg; pfam00072 767817003039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817003040 active site 767817003041 phosphorylation site [posttranslational modification] 767817003042 intermolecular recognition site; other site 767817003043 dimerization interface [polypeptide binding]; other site 767817003044 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817003045 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817003046 DNA binding site [nucleotide binding] 767817003047 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817003048 dimerization interface [polypeptide binding]; other site 767817003049 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817003050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817003051 dimer interface [polypeptide binding]; other site 767817003052 phosphorylation site [posttranslational modification] 767817003053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817003054 ATP binding site [chemical binding]; other site 767817003055 Mg2+ binding site [ion binding]; other site 767817003056 G-X-G motif; other site 767817003057 FOG: CBS domain [General function prediction only]; Region: COG0517 767817003058 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 767817003059 Sporulation and spore germination; Region: Germane; pfam10646 767817003060 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 767817003061 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817003062 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817003063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767817003064 4Fe-4S binding domain; Region: Fer4; pfam00037 767817003065 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817003066 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 767817003067 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 767817003068 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 767817003069 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 767817003070 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 767817003071 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 767817003072 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 767817003073 nickel binding site [ion binding]; other site 767817003074 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 767817003075 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 767817003076 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 767817003077 HupF/HypC family; Region: HupF_HypC; pfam01455 767817003078 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 767817003079 Hydrogenase formation hypA family; Region: HypD; cl12072 767817003080 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 767817003081 dimerization interface [polypeptide binding]; other site 767817003082 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 767817003083 ATP binding site [chemical binding]; other site 767817003084 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817003085 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 767817003086 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 767817003087 FOG: CBS domain [General function prediction only]; Region: COG0517 767817003088 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 767817003089 Acylphosphatase; Region: Acylphosphatase; pfam00708 767817003090 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 767817003091 HypF finger; Region: zf-HYPF; pfam07503 767817003092 HypF finger; Region: zf-HYPF; pfam07503 767817003093 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 767817003094 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 767817003095 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 767817003096 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 767817003097 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767817003098 catalytic residues [active] 767817003099 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 767817003100 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 767817003101 Malic enzyme, N-terminal domain; Region: malic; pfam00390 767817003102 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 767817003103 putative NAD(P) binding site [chemical binding]; other site 767817003104 CGGC domain; Region: CGGC; pfam08821 767817003105 Predicted metal-binding protein [Function unknown]; Region: COG5561 767817003106 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 767817003107 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 767817003108 ACS interaction site; other site 767817003109 CODH interaction site; other site 767817003110 cubane metal cluster (B-cluster) [ion binding]; other site 767817003111 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 767817003112 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 767817003113 Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH)...; Region: ACS_2; cd01917 767817003114 CODH interaction site; other site 767817003115 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 767817003116 Protein of unknown function (DUF503); Region: DUF503; pfam04456 767817003117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817003118 Coenzyme A binding pocket [chemical binding]; other site 767817003119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817003120 Coenzyme A binding pocket [chemical binding]; other site 767817003121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767817003122 putative substrate translocation pore; other site 767817003123 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767817003124 Flagellin N-methylase; Region: FliB; pfam03692 767817003125 Ubiquitin-like proteins; Region: UBQ; cl00155 767817003126 charged pocket; other site 767817003127 hydrophobic patch; other site 767817003128 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 767817003129 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 767817003130 dimer interface [polypeptide binding]; other site 767817003131 putative functional site; other site 767817003132 putative MPT binding site; other site 767817003133 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 767817003134 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 767817003135 dimer interface [polypeptide binding]; other site 767817003136 putative functional site; other site 767817003137 putative MPT binding site; other site 767817003138 PBP superfamily domain; Region: PBP_like; pfam12727 767817003139 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 767817003140 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 767817003141 MPT binding site; other site 767817003142 trimer interface [polypeptide binding]; other site 767817003143 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 767817003144 oligomerisation interface [polypeptide binding]; other site 767817003145 mobile loop; other site 767817003146 roof hairpin; other site 767817003147 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 767817003148 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 767817003149 ring oligomerisation interface [polypeptide binding]; other site 767817003150 ATP/Mg binding site [chemical binding]; other site 767817003151 stacking interactions; other site 767817003152 hinge regions; other site 767817003153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817003154 non-specific DNA binding site [nucleotide binding]; other site 767817003155 salt bridge; other site 767817003156 sequence-specific DNA binding site [nucleotide binding]; other site 767817003157 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 767817003158 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 767817003159 Methyltransferase domain; Region: Methyltransf_26; pfam13659 767817003160 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 767817003161 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 767817003162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 767817003163 TIGR02687 family protein; Region: TIGR02687 767817003164 PglZ domain; Region: PglZ; pfam08665 767817003165 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 767817003166 toxin interface [polypeptide binding]; other site 767817003167 Zn binding site [ion binding]; other site 767817003168 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 767817003169 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 767817003170 dimer interface [polypeptide binding]; other site 767817003171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817003172 catalytic residue [active] 767817003173 EamA-like transporter family; Region: EamA; pfam00892 767817003174 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 767817003175 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 767817003176 DNA binding site [nucleotide binding] 767817003177 active site 767817003178 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 767817003179 MviN-like protein; Region: MVIN; pfam03023 767817003180 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767817003181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817003182 Walker A/P-loop; other site 767817003183 ATP binding site [chemical binding]; other site 767817003184 Q-loop/lid; other site 767817003185 ABC transporter signature motif; other site 767817003186 Walker B; other site 767817003187 D-loop; other site 767817003188 H-loop/switch region; other site 767817003189 ABC transporter; Region: ABC_tran_2; pfam12848 767817003190 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767817003191 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 767817003192 UbiA prenyltransferase family; Region: UbiA; pfam01040 767817003193 Family description; Region: VCBS; pfam13517 767817003194 Family description; Region: VCBS; pfam13517 767817003195 Family description; Region: VCBS; pfam13517 767817003196 Family description; Region: VCBS; pfam13517 767817003197 Family description; Region: VCBS; pfam13517 767817003198 Family description; Region: VCBS; pfam13517 767817003199 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 767817003200 methionine sulfoxide reductase B; Provisional; Region: PRK00222 767817003201 SelR domain; Region: SelR; pfam01641 767817003202 Transposase domain (DUF772); Region: DUF772; pfam05598 767817003203 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767817003204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817003205 non-specific DNA binding site [nucleotide binding]; other site 767817003206 salt bridge; other site 767817003207 sequence-specific DNA binding site [nucleotide binding]; other site 767817003208 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 767817003209 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 767817003210 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 767817003211 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 767817003212 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 767817003213 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 767817003214 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 767817003215 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 767817003216 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 767817003217 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 767817003218 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 767817003219 DNA binding residues [nucleotide binding] 767817003220 Peptidase family M48; Region: Peptidase_M48; cl12018 767817003221 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 767817003222 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 767817003223 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 767817003224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817003225 S-adenosylmethionine binding site [chemical binding]; other site 767817003226 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767817003227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767817003228 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767817003229 dimerization interface [polypeptide binding]; other site 767817003230 Transcriptional regulator [Transcription]; Region: LytR; COG1316 767817003231 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 767817003232 Penicillinase repressor; Region: Pencillinase_R; pfam03965 767817003233 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 767817003234 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 767817003235 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 767817003236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817003237 Coenzyme A binding pocket [chemical binding]; other site 767817003238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817003239 Coenzyme A binding pocket [chemical binding]; other site 767817003240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817003241 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 767817003242 Coenzyme A binding pocket [chemical binding]; other site 767817003243 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 767817003244 active site 767817003245 NTP binding site [chemical binding]; other site 767817003246 metal binding triad [ion binding]; metal-binding site 767817003247 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 767817003248 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 767817003249 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 767817003250 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 767817003251 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817003252 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817003253 DNA binding residues [nucleotide binding] 767817003254 Putative zinc-finger; Region: zf-HC2; pfam13490 767817003255 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 767817003256 Predicted amidohydrolase [General function prediction only]; Region: COG0388 767817003257 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 767817003258 putative active site [active] 767817003259 catalytic triad [active] 767817003260 dimer interface [polypeptide binding]; other site 767817003261 GTP-binding protein YchF; Reviewed; Region: PRK09601 767817003262 YchF GTPase; Region: YchF; cd01900 767817003263 G1 box; other site 767817003264 GTP/Mg2+ binding site [chemical binding]; other site 767817003265 Switch I region; other site 767817003266 G2 box; other site 767817003267 Switch II region; other site 767817003268 G3 box; other site 767817003269 G4 box; other site 767817003270 G5 box; other site 767817003271 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 767817003272 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767817003273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 767817003274 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817003275 Coat F domain; Region: Coat_F; pfam07875 767817003276 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 767817003277 hydroxyglutarate oxidase; Provisional; Region: PRK11728 767817003278 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 767817003279 DAK2 domain; Region: Dak2; pfam02734 767817003280 EDD domain protein, DegV family; Region: DegV; TIGR00762 767817003281 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767817003282 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767817003283 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767817003284 ABC transporter; Region: ABC_tran_2; pfam12848 767817003285 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767817003286 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 767817003287 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 767817003288 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 767817003289 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767817003290 putative active site [active] 767817003291 putative metal binding site [ion binding]; other site 767817003292 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767817003293 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767817003294 substrate binding pocket [chemical binding]; other site 767817003295 membrane-bound complex binding site; other site 767817003296 hinge residues; other site 767817003297 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 767817003298 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 767817003299 FMN binding site [chemical binding]; other site 767817003300 substrate binding site [chemical binding]; other site 767817003301 putative catalytic residue [active] 767817003302 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 767817003303 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 767817003304 trimer interface [polypeptide binding]; other site 767817003305 putative metal binding site [ion binding]; other site 767817003306 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 767817003307 UbiA prenyltransferase family; Region: UbiA; pfam01040 767817003308 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767817003309 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767817003310 ligand binding site [chemical binding]; other site 767817003311 flexible hinge region; other site 767817003312 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 767817003313 non-specific DNA interactions [nucleotide binding]; other site 767817003314 DNA binding site [nucleotide binding] 767817003315 sequence specific DNA binding site [nucleotide binding]; other site 767817003316 putative cAMP binding site [chemical binding]; other site 767817003317 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767817003318 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 767817003319 ligand binding site [chemical binding]; other site 767817003320 flexible hinge region; other site 767817003321 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 767817003322 putative switch regulator; other site 767817003323 non-specific DNA interactions [nucleotide binding]; other site 767817003324 DNA binding site [nucleotide binding] 767817003325 sequence specific DNA binding site [nucleotide binding]; other site 767817003326 putative cAMP binding site [chemical binding]; other site 767817003327 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 767817003328 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767817003329 Ligand Binding Site [chemical binding]; other site 767817003330 CrcB-like protein; Region: CRCB; pfam02537 767817003331 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 767817003332 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 767817003333 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 767817003334 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 767817003335 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 767817003336 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 767817003337 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 767817003338 CPxP motif; other site 767817003339 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 767817003340 SLBB domain; Region: SLBB; pfam10531 767817003341 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 767817003342 Helix-hairpin-helix motif; Region: HHH; pfam00633 767817003343 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 767817003344 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 767817003345 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 767817003346 Competence protein; Region: Competence; pfam03772 767817003347 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 767817003348 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 767817003349 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 767817003350 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 767817003351 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 767817003352 Protein of unknown function DUF111; Region: DUF111; pfam01969 767817003353 GEMM cis-regulatory element; Desgi_1305; IMG reference gene:2508512270 767817003354 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 767817003355 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 767817003356 transmembrane helices; other site 767817003357 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767817003358 Ubiquitin-like proteins; Region: UBQ; cl00155 767817003359 charged pocket; other site 767817003360 hydrophobic patch; other site 767817003361 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 767817003362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 767817003363 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 767817003364 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817003365 FeS/SAM binding site; other site 767817003366 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 767817003367 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 767817003368 trimer interface [polypeptide binding]; other site 767817003369 dimer interface [polypeptide binding]; other site 767817003370 putative active site [active] 767817003371 MOSC domain; Region: MOSC; pfam03473 767817003372 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 767817003373 Walker A motif; other site 767817003374 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 767817003375 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 767817003376 ATP binding site [chemical binding]; other site 767817003377 substrate interface [chemical binding]; other site 767817003378 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 767817003379 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 767817003380 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 767817003381 Membrane protein of unknown function; Region: DUF360; pfam04020 767817003382 Minimal MMP-like domain found in Thermus thermophilus TTHA0227, Acidothermus cellulolyticus ACEL2062 and similar proteins; Region: MMP_TTHA0227_like; cl01577 767817003383 stage II sporulation protein P; Region: spore_II_P; TIGR02867 767817003384 Putative Fe-S cluster; Region: FeS; cl17515 767817003385 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 767817003386 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 767817003387 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 767817003388 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767817003389 GTP-binding protein LepA; Provisional; Region: PRK05433 767817003390 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 767817003391 G1 box; other site 767817003392 putative GEF interaction site [polypeptide binding]; other site 767817003393 GTP/Mg2+ binding site [chemical binding]; other site 767817003394 Switch I region; other site 767817003395 G2 box; other site 767817003396 G3 box; other site 767817003397 Switch II region; other site 767817003398 G4 box; other site 767817003399 G5 box; other site 767817003400 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 767817003401 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 767817003402 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 767817003403 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 767817003404 HemN C-terminal domain; Region: HemN_C; pfam06969 767817003405 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 767817003406 HTH domain; Region: HTH_11; cl17392 767817003407 GrpE; Region: GrpE; pfam01025 767817003408 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 767817003409 dimer interface [polypeptide binding]; other site 767817003410 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 767817003411 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 767817003412 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 767817003413 nucleotide binding site [chemical binding]; other site 767817003414 NEF interaction site [polypeptide binding]; other site 767817003415 SBD interface [polypeptide binding]; other site 767817003416 chaperone protein DnaJ; Provisional; Region: PRK10767 767817003417 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 767817003418 HSP70 interaction site [polypeptide binding]; other site 767817003419 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 767817003420 substrate binding site [polypeptide binding]; other site 767817003421 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 767817003422 Zn binding sites [ion binding]; other site 767817003423 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 767817003424 dimer interface [polypeptide binding]; other site 767817003425 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 767817003426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817003427 S-adenosylmethionine binding site [chemical binding]; other site 767817003428 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 767817003429 RNA methyltransferase, RsmE family; Region: TIGR00046 767817003430 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 767817003431 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 767817003432 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 767817003433 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 767817003434 nucleotide binding site/active site [active] 767817003435 HIT family signature motif; other site 767817003436 catalytic residue [active] 767817003437 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 767817003438 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 767817003439 hypothetical protein; Provisional; Region: PRK13665 767817003440 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 767817003441 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 767817003442 transmembrane helices; other site 767817003443 Coenzyme A transferase; Region: CoA_trans; cl17247 767817003444 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 767817003445 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 767817003446 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 767817003447 CPxP motif; other site 767817003448 DsrE/DsrF-like family; Region: DrsE; pfam02635 767817003449 selenophosphate synthetase; Provisional; Region: PRK00943 767817003450 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 767817003451 dimerization interface [polypeptide binding]; other site 767817003452 putative ATP binding site [chemical binding]; other site 767817003453 YabP family; Region: YabP; cl06766 767817003454 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 767817003455 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 767817003456 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 767817003457 PhoH-like protein; Region: PhoH; pfam02562 767817003458 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 767817003459 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 767817003460 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817003461 Zn2+ binding site [ion binding]; other site 767817003462 Mg2+ binding site [ion binding]; other site 767817003463 metal-binding heat shock protein; Provisional; Region: PRK00016 767817003464 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 767817003465 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 767817003466 active site 767817003467 catalytic motif [active] 767817003468 Zn binding site [ion binding]; other site 767817003469 GTPase Era; Reviewed; Region: era; PRK00089 767817003470 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 767817003471 G1 box; other site 767817003472 GTP/Mg2+ binding site [chemical binding]; other site 767817003473 Switch I region; other site 767817003474 G2 box; other site 767817003475 Switch II region; other site 767817003476 G3 box; other site 767817003477 G4 box; other site 767817003478 G5 box; other site 767817003479 KH domain; Region: KH_2; pfam07650 767817003480 ykoK leader; Desgi_1353; IMG reference gene:2508512318 767817003481 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 767817003482 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 767817003483 oligomer interface [polypeptide binding]; other site 767817003484 metal binding site [ion binding]; metal-binding site 767817003485 metal binding site [ion binding]; metal-binding site 767817003486 putative Cl binding site [ion binding]; other site 767817003487 aspartate ring; other site 767817003488 basic sphincter; other site 767817003489 hydrophobic gate; other site 767817003490 periplasmic entrance; other site 767817003491 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817003492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817003493 active site 767817003494 phosphorylation site [posttranslational modification] 767817003495 intermolecular recognition site; other site 767817003496 dimerization interface [polypeptide binding]; other site 767817003497 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817003498 DNA binding site [nucleotide binding] 767817003499 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 767817003500 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817003501 dimerization interface [polypeptide binding]; other site 767817003502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817003503 dimer interface [polypeptide binding]; other site 767817003504 phosphorylation site [posttranslational modification] 767817003505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817003506 ATP binding site [chemical binding]; other site 767817003507 Mg2+ binding site [ion binding]; other site 767817003508 G-X-G motif; other site 767817003509 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 767817003510 HlyD family secretion protein; Region: HlyD_3; pfam13437 767817003511 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767817003512 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767817003513 Walker A/P-loop; other site 767817003514 ATP binding site [chemical binding]; other site 767817003515 Q-loop/lid; other site 767817003516 ABC transporter signature motif; other site 767817003517 Walker B; other site 767817003518 D-loop; other site 767817003519 H-loop/switch region; other site 767817003520 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767817003521 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767817003522 FtsX-like permease family; Region: FtsX; pfam02687 767817003523 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 767817003524 Recombination protein O N terminal; Region: RecO_N; pfam11967 767817003525 Recombination protein O C terminal; Region: RecO_C; pfam02565 767817003526 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 767817003527 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 767817003528 dimer interface [polypeptide binding]; other site 767817003529 motif 1; other site 767817003530 active site 767817003531 motif 2; other site 767817003532 motif 3; other site 767817003533 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 767817003534 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767817003535 dimerization interface [polypeptide binding]; other site 767817003536 putative DNA binding site [nucleotide binding]; other site 767817003537 putative Zn2+ binding site [ion binding]; other site 767817003538 FOG: CBS domain [General function prediction only]; Region: COG0517 767817003539 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 767817003540 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 767817003541 pyruvate phosphate dikinase; Provisional; Region: PRK09279 767817003542 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 767817003543 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 767817003544 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 767817003545 ykkC-yxkD leader; Desgi_1369; IMG reference gene:2508512334 767817003546 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 767817003547 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 767817003548 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817003549 non-specific DNA binding site [nucleotide binding]; other site 767817003550 salt bridge; other site 767817003551 sequence-specific DNA binding site [nucleotide binding]; other site 767817003552 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 767817003553 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 767817003554 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 767817003555 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 767817003556 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767817003557 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 767817003558 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817003559 Zn2+ binding site [ion binding]; other site 767817003560 Mg2+ binding site [ion binding]; other site 767817003561 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 767817003562 DNA primase; Validated; Region: dnaG; PRK05667 767817003563 CHC2 zinc finger; Region: zf-CHC2; pfam01807 767817003564 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 767817003565 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 767817003566 active site 767817003567 metal binding site [ion binding]; metal-binding site 767817003568 interdomain interaction site; other site 767817003569 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 767817003570 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 767817003571 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 767817003572 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817003573 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 767817003574 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817003575 DNA binding residues [nucleotide binding] 767817003576 Predicted membrane protein [Function unknown]; Region: COG2323 767817003577 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 767817003578 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 767817003579 Predicted membrane protein [Function unknown]; Region: COG2323 767817003580 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 767817003581 SpoVA protein; Region: SpoVA; cl04298 767817003582 stage V sporulation protein AD; Provisional; Region: PRK12404 767817003583 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 767817003584 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 767817003585 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 767817003586 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 767817003587 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767817003588 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 767817003589 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 767817003590 Spore germination protein; Region: Spore_permease; cl17796 767817003591 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 767817003592 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 767817003593 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 767817003594 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 767817003595 YKOF-related Family; Region: Ykof; pfam07615 767817003596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 767817003597 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767817003598 Ferritin-like domain; Region: Ferritin; pfam00210 767817003599 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 767817003600 dinuclear metal binding motif [ion binding]; other site 767817003601 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 767817003602 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 767817003603 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 767817003604 nickel binding site [ion binding]; other site 767817003605 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767817003606 Ligand Binding Site [chemical binding]; other site 767817003607 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 767817003608 Family of unknown function (DUF633); Region: DUF633; pfam04816 767817003609 Uncharacterized conserved protein [Function unknown]; Region: COG0327 767817003610 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 767817003611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 767817003612 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 767817003613 Uncharacterized conserved protein [Function unknown]; Region: COG0327 767817003614 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 767817003615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817003616 active site 767817003617 phosphorylation site [posttranslational modification] 767817003618 intermolecular recognition site; other site 767817003619 dimerization interface [polypeptide binding]; other site 767817003620 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 767817003621 DNA binding residues [nucleotide binding] 767817003622 dimerization interface [polypeptide binding]; other site 767817003623 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 767817003624 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 767817003625 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 767817003626 Histidine kinase; Region: HisKA_3; pfam07730 767817003627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817003628 ATP binding site [chemical binding]; other site 767817003629 Mg2+ binding site [ion binding]; other site 767817003630 G-X-G motif; other site 767817003631 Activator of aromatic catabolism; Region: XylR_N; pfam06505 767817003632 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 767817003633 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 767817003634 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 767817003635 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 767817003636 NAD binding site [chemical binding]; other site 767817003637 ligand binding site [chemical binding]; other site 767817003638 catalytic site [active] 767817003639 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 767817003640 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 767817003641 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 767817003642 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 767817003643 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 767817003644 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 767817003645 dimer interface [polypeptide binding]; other site 767817003646 PYR/PP interface [polypeptide binding]; other site 767817003647 TPP binding site [chemical binding]; other site 767817003648 substrate binding site [chemical binding]; other site 767817003649 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 767817003650 TPP-binding site; other site 767817003651 4Fe-4S binding domain; Region: Fer4; pfam00037 767817003652 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 767817003653 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817003654 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 767817003655 acyl-activating enzyme (AAE) consensus motif; other site 767817003656 AMP binding site [chemical binding]; other site 767817003657 active site 767817003658 CoA binding site [chemical binding]; other site 767817003659 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 767817003660 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 767817003661 Na binding site [ion binding]; other site 767817003662 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 767817003663 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817003664 acyl-activating enzyme (AAE) consensus motif; other site 767817003665 AMP binding site [chemical binding]; other site 767817003666 active site 767817003667 CoA binding site [chemical binding]; other site 767817003668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817003669 Coenzyme A binding pocket [chemical binding]; other site 767817003670 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 767817003671 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 767817003672 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 767817003673 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 767817003674 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817003675 substrate binding site [chemical binding]; other site 767817003676 oxyanion hole (OAH) forming residues; other site 767817003677 trimer interface [polypeptide binding]; other site 767817003678 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 767817003679 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 767817003680 Metallopeptidase family M24; Region: Peptidase_M24; pfam00557 767817003681 active site 767817003682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767817003683 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 767817003684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767817003685 Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxy acid dehydrogenase family; Region: formate_dh_like; cd05198 767817003686 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767817003687 ligand binding site [chemical binding]; other site 767817003688 NAD binding site [chemical binding]; other site 767817003689 dimerization interface [polypeptide binding]; other site 767817003690 catalytic site [active] 767817003691 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817003692 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 767817003693 acyl-activating enzyme (AAE) consensus motif; other site 767817003694 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 767817003695 acyl-activating enzyme (AAE) consensus motif; other site 767817003696 putative AMP binding site [chemical binding]; other site 767817003697 putative active site [active] 767817003698 putative CoA binding site [chemical binding]; other site 767817003699 Ubiquitin-like proteins; Region: UBQ; cl00155 767817003700 charged pocket; other site 767817003701 hydrophobic patch; other site 767817003702 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 767817003703 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 767817003704 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 767817003705 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767817003706 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767817003707 active site 767817003708 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 767817003709 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 767817003710 Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959 767817003711 dimer interface [polypeptide binding]; other site 767817003712 acyl-activating enzyme (AAE) consensus motif; other site 767817003713 putative active site [active] 767817003714 putative AMP binding site [chemical binding]; other site 767817003715 putative CoA binding site [chemical binding]; other site 767817003716 chemical substrate binding site [chemical binding]; other site 767817003717 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817003718 PAS domain; Region: PAS_9; pfam13426 767817003719 putative active site [active] 767817003720 heme pocket [chemical binding]; other site 767817003721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817003722 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 767817003723 Walker A motif; other site 767817003724 ATP binding site [chemical binding]; other site 767817003725 Walker B motif; other site 767817003726 arginine finger; other site 767817003727 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 767817003728 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767817003729 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767817003730 active site 767817003731 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 767817003732 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767817003733 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 767817003734 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 767817003735 putative active site [active] 767817003736 putative CoA binding site [chemical binding]; other site 767817003737 nudix motif; other site 767817003738 metal binding site [ion binding]; metal-binding site 767817003739 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767817003740 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767817003741 ligand binding site [chemical binding]; other site 767817003742 flexible hinge region; other site 767817003743 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 767817003744 putative switch regulator; other site 767817003745 non-specific DNA interactions [nucleotide binding]; other site 767817003746 DNA binding site [nucleotide binding] 767817003747 sequence specific DNA binding site [nucleotide binding]; other site 767817003748 putative cAMP binding site [chemical binding]; other site 767817003749 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767817003750 Cysteine-rich domain; Region: CCG; pfam02754 767817003751 Cysteine-rich domain; Region: CCG; pfam02754 767817003752 AAA domain; Region: AAA_28; pfam13521 767817003753 AAA domain; Region: AAA_17; pfam13207 767817003754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817003755 Coenzyme A binding pocket [chemical binding]; other site 767817003756 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 767817003757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817003758 active site 767817003759 phosphorylation site [posttranslational modification] 767817003760 intermolecular recognition site; other site 767817003761 dimerization interface [polypeptide binding]; other site 767817003762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817003763 Walker A motif; other site 767817003764 ATP binding site [chemical binding]; other site 767817003765 Walker B motif; other site 767817003766 arginine finger; other site 767817003767 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817003768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817003769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 767817003770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817003771 dimer interface [polypeptide binding]; other site 767817003772 phosphorylation site [posttranslational modification] 767817003773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817003774 ATP binding site [chemical binding]; other site 767817003775 Mg2+ binding site [ion binding]; other site 767817003776 G-X-G motif; other site 767817003777 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 767817003778 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 767817003779 FOG: CBS domain [General function prediction only]; Region: COG0517 767817003780 Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739 767817003781 Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918 767817003782 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 767817003783 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 767817003784 homotetramer interface [polypeptide binding]; other site 767817003785 FMN binding site [chemical binding]; other site 767817003786 homodimer contacts [polypeptide binding]; other site 767817003787 putative active site [active] 767817003788 putative substrate binding site [chemical binding]; other site 767817003789 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 767817003790 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 767817003791 putative dimer interface [polypeptide binding]; other site 767817003792 active site pocket [active] 767817003793 putative cataytic base [active] 767817003794 Uncharacterized conserved protein [Function unknown]; Region: COG1751 767817003795 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 767817003796 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 767817003797 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 767817003798 EcsC protein family; Region: EcsC; pfam12787 767817003799 glutamate racemase; Provisional; Region: PRK00865 767817003800 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 767817003801 domain II; other site 767817003802 domain III; other site 767817003803 nucleotide binding site [chemical binding]; other site 767817003804 DNA binding groove [nucleotide binding] 767817003805 catalytic site [active] 767817003806 domain IV; other site 767817003807 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 767817003808 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 767817003809 Fic family protein [Function unknown]; Region: COG3177 767817003810 Fic/DOC family; Region: Fic; pfam02661 767817003811 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 767817003812 putative DNA binding helix; other site 767817003813 hypothetical protein; Reviewed; Region: PRK00024 767817003814 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 767817003815 MPN+ (JAMM) motif; other site 767817003816 Zinc-binding site [ion binding]; other site 767817003817 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 767817003818 putative active site [active] 767817003819 catalytic site [active] 767817003820 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767817003821 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817003822 ATP binding site [chemical binding]; other site 767817003823 putative Mg++ binding site [ion binding]; other site 767817003824 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817003825 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 767817003826 nucleotide binding region [chemical binding]; other site 767817003827 ATP-binding site [chemical binding]; other site 767817003828 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 767817003829 Transposase domain (DUF772); Region: DUF772; pfam05598 767817003830 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767817003831 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 767817003832 DNA methylase; Region: N6_N4_Mtase; pfam01555 767817003833 DNA methylase; Region: N6_N4_Mtase; cl17433 767817003834 Restriction endonuclease [Defense mechanisms]; Region: COG3587 767817003835 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817003836 ATP binding site [chemical binding]; other site 767817003837 putative Mg++ binding site [ion binding]; other site 767817003838 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 767817003839 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 767817003840 generic binding surface I; other site 767817003841 generic binding surface II; other site 767817003842 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817003843 Zn2+ binding site [ion binding]; other site 767817003844 Mg2+ binding site [ion binding]; other site 767817003845 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 767817003846 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 767817003847 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 767817003848 putative active site [active] 767817003849 putative metal-binding site [ion binding]; other site 767817003850 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 767817003851 Part of AAA domain; Region: AAA_19; pfam13245 767817003852 AAA domain; Region: AAA_14; pfam13173 767817003853 Family description; Region: UvrD_C_2; pfam13538 767817003854 Domain of unknown function DUF87; Region: DUF87; pfam01935 767817003855 AAA-like domain; Region: AAA_10; pfam12846 767817003856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817003857 Walker A motif; other site 767817003858 ATP binding site [chemical binding]; other site 767817003859 Walker B motif; other site 767817003860 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 767817003861 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 767817003862 DNA-binding interface [nucleotide binding]; DNA binding site 767817003863 Integrase core domain; Region: rve; pfam00665 767817003864 SIR2-like domain; Region: SIR2_2; pfam13289 767817003865 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 767817003866 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 767817003867 Phage integrase family; Region: Phage_integrase; pfam00589 767817003868 active site 767817003869 DNA binding site [nucleotide binding] 767817003870 Int/Topo IB signature motif; other site 767817003871 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 767817003872 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 767817003873 active site 767817003874 NAD binding site [chemical binding]; other site 767817003875 metal binding site [ion binding]; metal-binding site 767817003876 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 767817003877 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 767817003878 Spore germination protein; Region: Spore_permease; cl17796 767817003879 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 767817003880 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 767817003881 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 767817003882 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 767817003883 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 767817003884 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 767817003885 putative active site [active] 767817003886 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 767817003887 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767817003888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817003889 homodimer interface [polypeptide binding]; other site 767817003890 catalytic residue [active] 767817003891 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 767817003892 Transcriptional regulators [Transcription]; Region: FadR; COG2186 767817003893 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767817003894 DNA-binding site [nucleotide binding]; DNA binding site 767817003895 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 767817003896 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 767817003897 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767817003898 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 767817003899 TrkA-N domain; Region: TrkA_N; pfam02254 767817003900 TrkA-C domain; Region: TrkA_C; pfam02080 767817003901 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767817003902 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767817003903 ligand binding site [chemical binding]; other site 767817003904 flexible hinge region; other site 767817003905 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 767817003906 non-specific DNA interactions [nucleotide binding]; other site 767817003907 DNA binding site [nucleotide binding] 767817003908 sequence specific DNA binding site [nucleotide binding]; other site 767817003909 putative cAMP binding site [chemical binding]; other site 767817003910 transmembrane helices; other site 767817003911 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767817003912 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767817003913 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 767817003914 L-aspartate oxidase; Provisional; Region: PRK06175 767817003915 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 767817003916 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817003917 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 767817003918 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 767817003919 homotrimer interaction site [polypeptide binding]; other site 767817003920 putative active site [active] 767817003921 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 767817003922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817003923 ATP binding site [chemical binding]; other site 767817003924 Mg2+ binding site [ion binding]; other site 767817003925 G-X-G motif; other site 767817003926 Accessory gene regulator B; Region: AgrB; pfam04647 767817003927 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 767817003928 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817003929 dimerization interface [polypeptide binding]; other site 767817003930 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 767817003931 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 767817003932 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 767817003933 molybdopterin cofactor binding site; other site 767817003934 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 767817003935 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 767817003936 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 767817003937 molybdopterin cofactor binding site; other site 767817003938 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 767817003939 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 767817003940 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 767817003941 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 767817003942 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 767817003943 PAS domain S-box; Region: sensory_box; TIGR00229 767817003944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817003945 putative active site [active] 767817003946 heme pocket [chemical binding]; other site 767817003947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817003948 dimer interface [polypeptide binding]; other site 767817003949 phosphorylation site [posttranslational modification] 767817003950 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 767817003951 Na2 binding site [ion binding]; other site 767817003952 putative substrate binding site 1 [chemical binding]; other site 767817003953 Na binding site 1 [ion binding]; other site 767817003954 putative substrate binding site 2 [chemical binding]; other site 767817003955 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 767817003956 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 767817003957 Protein of unknown function (DUF1616); Region: DUF1616; pfam07760 767817003958 CAAX protease self-immunity; Region: Abi; pfam02517 767817003959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817003960 ATP binding site [chemical binding]; other site 767817003961 Mg2+ binding site [ion binding]; other site 767817003962 G-X-G motif; other site 767817003963 Accessory gene regulator B; Region: AgrB; pfam04647 767817003964 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 767817003965 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 767817003966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817003967 active site 767817003968 phosphorylation site [posttranslational modification] 767817003969 intermolecular recognition site; other site 767817003970 dimerization interface [polypeptide binding]; other site 767817003971 LytTr DNA-binding domain; Region: LytTR; smart00850 767817003972 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 767817003973 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817003974 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 767817003975 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 767817003976 Ligand binding site; other site 767817003977 Putative Catalytic site; other site 767817003978 DXD motif; other site 767817003979 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817003980 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767817003981 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767817003982 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817003983 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 767817003984 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817003985 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767817003986 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 767817003987 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767817003988 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 767817003989 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 767817003990 ligand-binding site [chemical binding]; other site 767817003991 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 767817003992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767817003993 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 767817003994 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 767817003995 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 767817003996 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 767817003997 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 767817003998 active site 767817003999 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 767817004000 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 767817004001 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 767817004002 Substrate binding site; other site 767817004003 Cupin domain; Region: Cupin_2; cl17218 767817004004 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 767817004005 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 767817004006 Substrate binding site; other site 767817004007 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 767817004008 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 767817004009 active site 767817004010 substrate binding site [chemical binding]; other site 767817004011 metal binding site [ion binding]; metal-binding site 767817004012 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767817004013 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767817004014 FtsX-like permease family; Region: FtsX; pfam02687 767817004015 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767817004016 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767817004017 Walker A/P-loop; other site 767817004018 ATP binding site [chemical binding]; other site 767817004019 Q-loop/lid; other site 767817004020 ABC transporter signature motif; other site 767817004021 Walker B; other site 767817004022 D-loop; other site 767817004023 H-loop/switch region; other site 767817004024 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 767817004025 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 767817004026 active site 767817004027 tetramer interface; other site 767817004028 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817004029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817004030 active site 767817004031 phosphorylation site [posttranslational modification] 767817004032 intermolecular recognition site; other site 767817004033 dimerization interface [polypeptide binding]; other site 767817004034 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817004035 DNA binding site [nucleotide binding] 767817004036 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817004037 dimerization interface [polypeptide binding]; other site 767817004038 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 767817004039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817004040 putative active site [active] 767817004041 heme pocket [chemical binding]; other site 767817004042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817004043 dimer interface [polypeptide binding]; other site 767817004044 phosphorylation site [posttranslational modification] 767817004045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817004046 ATP binding site [chemical binding]; other site 767817004047 Mg2+ binding site [ion binding]; other site 767817004048 G-X-G motif; other site 767817004049 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 767817004050 PhoU domain; Region: PhoU; pfam01895 767817004051 PhoU domain; Region: PhoU; pfam01895 767817004052 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 767817004053 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 767817004054 Walker A/P-loop; other site 767817004055 ATP binding site [chemical binding]; other site 767817004056 Q-loop/lid; other site 767817004057 ABC transporter signature motif; other site 767817004058 Walker B; other site 767817004059 D-loop; other site 767817004060 H-loop/switch region; other site 767817004061 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 767817004062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817004063 dimer interface [polypeptide binding]; other site 767817004064 conserved gate region; other site 767817004065 putative PBP binding loops; other site 767817004066 ABC-ATPase subunit interface; other site 767817004067 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 767817004068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817004069 dimer interface [polypeptide binding]; other site 767817004070 conserved gate region; other site 767817004071 putative PBP binding loops; other site 767817004072 ABC-ATPase subunit interface; other site 767817004073 PBP superfamily domain; Region: PBP_like_2; cl17296 767817004074 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 767817004075 stage V sporulation protein T; Region: spore_V_T; TIGR02851 767817004076 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 767817004077 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 767817004078 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 767817004079 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 767817004080 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 767817004081 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 767817004082 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 767817004083 aconitate hydratase; Validated; Region: PRK07229 767817004084 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 767817004085 substrate binding site [chemical binding]; other site 767817004086 ligand binding site [chemical binding]; other site 767817004087 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 767817004088 substrate binding site [chemical binding]; other site 767817004089 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 767817004090 Ferritin-like domain; Region: Ferritin; pfam00210 767817004091 dimanganese center [ion binding]; other site 767817004092 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 767817004093 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 767817004094 Na binding site [ion binding]; other site 767817004095 SWIM zinc finger; Region: SWIM; pfam04434 767817004096 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 767817004097 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 767817004098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817004099 ATP binding site [chemical binding]; other site 767817004100 putative Mg++ binding site [ion binding]; other site 767817004101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817004102 nucleotide binding region [chemical binding]; other site 767817004103 ATP-binding site [chemical binding]; other site 767817004104 Uncharacterized conserved protein [Function unknown]; Region: COG5495 767817004105 Rossmann-like domain; Region: Rossmann-like; pfam10727 767817004106 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 767817004107 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 767817004108 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 767817004109 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 767817004110 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 767817004111 PAS domain; Region: PAS; smart00091 767817004112 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 767817004113 PAS domain; Region: PAS; smart00091 767817004114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817004115 Walker A motif; other site 767817004116 ATP binding site [chemical binding]; other site 767817004117 Walker B motif; other site 767817004118 arginine finger; other site 767817004119 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817004120 hypothetical protein; Provisional; Region: PRK02237 767817004121 hypothetical protein; Provisional; Region: PRK02237 767817004122 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 767817004123 active site 767817004124 FMN binding site [chemical binding]; other site 767817004125 substrate binding site [chemical binding]; other site 767817004126 3Fe-4S cluster binding site [ion binding]; other site 767817004127 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 767817004128 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 767817004129 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 767817004130 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 767817004131 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817004132 catalytic loop [active] 767817004133 iron binding site [ion binding]; other site 767817004134 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 767817004135 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 767817004136 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 767817004137 Uncharacterized conserved protein [Function unknown]; Region: COG2461 767817004138 Family of unknown function (DUF438); Region: DUF438; pfam04282 767817004139 Hemerythrin-like domain; Region: Hr-like; cd12108 767817004140 Radical SAM superfamily; Region: Radical_SAM; pfam04055 767817004141 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 767817004142 FeS/SAM binding site; other site 767817004143 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767817004144 active site 767817004145 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 767817004146 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767817004147 MarR family; Region: MarR; pfam01047 767817004148 MarR family; Region: MarR_2; cl17246 767817004149 Potato inhibitor I family; Region: potato_inhibit; pfam00280 767817004150 MYM-type Zinc finger with FCS sequence motif; Region: zf-FCS; pfam06467 767817004151 Beta propeller domain; Region: Beta_propel; pfam09826 767817004152 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817004153 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 767817004154 putative active site [active] 767817004155 heme pocket [chemical binding]; other site 767817004156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817004157 putative active site [active] 767817004158 heme pocket [chemical binding]; other site 767817004159 PAS domain S-box; Region: sensory_box; TIGR00229 767817004160 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817004161 putative active site [active] 767817004162 heme pocket [chemical binding]; other site 767817004163 PAS domain S-box; Region: sensory_box; TIGR00229 767817004164 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817004165 putative active site [active] 767817004166 heme pocket [chemical binding]; other site 767817004167 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817004168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817004169 dimer interface [polypeptide binding]; other site 767817004170 phosphorylation site [posttranslational modification] 767817004171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817004172 ATP binding site [chemical binding]; other site 767817004173 Mg2+ binding site [ion binding]; other site 767817004174 G-X-G motif; other site 767817004175 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 767817004176 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 767817004177 Cysteine-rich domain; Region: CCG; pfam02754 767817004178 Cysteine-rich domain; Region: CCG; pfam02754 767817004179 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817004180 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817004181 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767817004182 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767817004183 ligand binding site [chemical binding]; other site 767817004184 flexible hinge region; other site 767817004185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817004186 Walker A motif; other site 767817004187 ATP binding site [chemical binding]; other site 767817004188 Walker B motif; other site 767817004189 arginine finger; other site 767817004190 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 767817004191 4Fe-4S binding domain; Region: Fer4_5; pfam12801 767817004192 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 767817004193 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 767817004194 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 767817004195 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 767817004196 putative NADH binding site [chemical binding]; other site 767817004197 putative active site [active] 767817004198 nudix motif; other site 767817004199 putative metal binding site [ion binding]; other site 767817004200 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 767817004201 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 767817004202 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 767817004203 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 767817004204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817004205 dimer interface [polypeptide binding]; other site 767817004206 conserved gate region; other site 767817004207 putative PBP binding loops; other site 767817004208 ABC-ATPase subunit interface; other site 767817004209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817004210 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 767817004211 Walker A/P-loop; other site 767817004212 ATP binding site [chemical binding]; other site 767817004213 Q-loop/lid; other site 767817004214 ABC transporter signature motif; other site 767817004215 Walker B; other site 767817004216 D-loop; other site 767817004217 H-loop/switch region; other site 767817004218 Uncharacterized conserved protein [Function unknown]; Region: COG2014 767817004219 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 767817004220 Domain of unknown function (DUF364); Region: DUF364; pfam04016 767817004221 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 767817004222 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 767817004223 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 767817004224 active site 767817004225 FMN binding site [chemical binding]; other site 767817004226 substrate binding site [chemical binding]; other site 767817004227 putative catalytic residue [active] 767817004228 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 767817004229 active site 767817004230 catalytic site [active] 767817004231 substrate binding site [chemical binding]; other site 767817004232 Nuclease-related domain; Region: NERD; pfam08378 767817004233 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 767817004234 pentamer interface [polypeptide binding]; other site 767817004235 dodecaamer interface [polypeptide binding]; other site 767817004236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 767817004237 PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301 767817004238 nucleic acid-binding interface [nucleotide binding]; other site 767817004239 transposase/IS protein; Provisional; Region: PRK09183 767817004240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817004241 Walker A motif; other site 767817004242 ATP binding site [chemical binding]; other site 767817004243 Walker B motif; other site 767817004244 arginine finger; other site 767817004245 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 767817004246 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 767817004247 N-acetyl-D-glucosamine binding site [chemical binding]; other site 767817004248 catalytic residue [active] 767817004249 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 767817004250 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 767817004251 CoA-binding site [chemical binding]; other site 767817004252 ATP-binding [chemical binding]; other site 767817004253 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 767817004254 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 767817004255 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 767817004256 DNA binding site [nucleotide binding] 767817004257 catalytic residue [active] 767817004258 H2TH interface [polypeptide binding]; other site 767817004259 putative catalytic residues [active] 767817004260 turnover-facilitating residue; other site 767817004261 intercalation triad [nucleotide binding]; other site 767817004262 8OG recognition residue [nucleotide binding]; other site 767817004263 putative reading head residues; other site 767817004264 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 767817004265 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 767817004266 DNA polymerase I; Provisional; Region: PRK05755 767817004267 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 767817004268 active site 767817004269 metal binding site 1 [ion binding]; metal-binding site 767817004270 putative 5' ssDNA interaction site; other site 767817004271 metal binding site 3; metal-binding site 767817004272 metal binding site 2 [ion binding]; metal-binding site 767817004273 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 767817004274 putative DNA binding site [nucleotide binding]; other site 767817004275 putative metal binding site [ion binding]; other site 767817004276 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 767817004277 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 767817004278 active site 767817004279 DNA binding site [nucleotide binding] 767817004280 catalytic site [active] 767817004281 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 767817004282 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 767817004283 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 767817004284 protein binding site [polypeptide binding]; other site 767817004285 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 767817004286 Catalytic dyad [active] 767817004287 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 767817004288 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 767817004289 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 767817004290 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 767817004291 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 767817004292 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 767817004293 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 767817004294 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 767817004295 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767817004296 active site 767817004297 catalytic tetrad [active] 767817004298 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767817004299 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 767817004300 AAA-like domain; Region: AAA_10; pfam12846 767817004301 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 767817004302 Replication-relaxation; Region: Replic_Relax; pfam13814 767817004303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817004304 sequence-specific DNA binding site [nucleotide binding]; other site 767817004305 salt bridge; other site 767817004306 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817004307 non-specific DNA binding site [nucleotide binding]; other site 767817004308 sequence-specific DNA binding site [nucleotide binding]; other site 767817004309 salt bridge; other site 767817004310 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 767817004311 DNA binding residues [nucleotide binding] 767817004312 Domain of unknown function (DUF955); Region: DUF955; pfam06114 767817004313 Protein of unknown function (DUF3782); Region: DUF3782; pfam12644 767817004314 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817004315 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817004316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817004317 non-specific DNA binding site [nucleotide binding]; other site 767817004318 salt bridge; other site 767817004319 sequence-specific DNA binding site [nucleotide binding]; other site 767817004320 Helix-turn-helix domain; Region: HTH_17; pfam12728 767817004321 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 767817004322 Helix-turn-helix domain; Region: HTH_17; pfam12728 767817004323 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 767817004324 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 767817004325 Int/Topo IB signature motif; other site 767817004326 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 767817004327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817004328 Walker A motif; other site 767817004329 ATP binding site [chemical binding]; other site 767817004330 Walker B motif; other site 767817004331 arginine finger; other site 767817004332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 767817004333 Integrase core domain; Region: rve; pfam00665 767817004334 Integrase core domain; Region: rve_3; cl15866 767817004335 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 767817004336 Homeodomain-like domain; Region: HTH_23; cl17451 767817004337 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 767817004338 dimerization interface [polypeptide binding]; other site 767817004339 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767817004340 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767817004341 Probable transposase; Region: OrfB_IS605; pfam01385 767817004342 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767817004343 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767817004344 LexA repressor; Validated; Region: PRK00215 767817004345 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 767817004346 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 767817004347 Catalytic site [active] 767817004348 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767817004349 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767817004350 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 767817004351 putative dimerization interface [polypeptide binding]; other site 767817004352 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 767817004353 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 767817004354 4Fe-4S binding domain; Region: Fer4; pfam00037 767817004355 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 767817004356 thiosulfate reductase PhsA; Provisional; Region: PRK15488 767817004357 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 767817004358 putative [Fe4-S4] binding site [ion binding]; other site 767817004359 putative molybdopterin cofactor binding site [chemical binding]; other site 767817004360 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 767817004361 putative molybdopterin cofactor binding site; other site 767817004362 YtxC-like family; Region: YtxC; pfam08812 767817004363 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 767817004364 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 767817004365 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 767817004366 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 767817004367 active site 767817004368 dimer interface [polypeptide binding]; other site 767817004369 motif 1; other site 767817004370 motif 2; other site 767817004371 motif 3; other site 767817004372 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 767817004373 anticodon binding site; other site 767817004374 translation initiation factor IF-3; Region: infC; TIGR00168 767817004375 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 767817004376 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 767817004377 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 767817004378 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 767817004379 23S rRNA binding site [nucleotide binding]; other site 767817004380 L21 binding site [polypeptide binding]; other site 767817004381 L13 binding site [polypeptide binding]; other site 767817004382 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 767817004383 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 767817004384 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 767817004385 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 767817004386 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 767817004387 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 767817004388 dimer interface [polypeptide binding]; other site 767817004389 motif 1; other site 767817004390 active site 767817004391 motif 2; other site 767817004392 motif 3; other site 767817004393 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 767817004394 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 767817004395 putative tRNA-binding site [nucleotide binding]; other site 767817004396 B3/4 domain; Region: B3_4; pfam03483 767817004397 tRNA synthetase B5 domain; Region: B5; smart00874 767817004398 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 767817004399 dimer interface [polypeptide binding]; other site 767817004400 motif 1; other site 767817004401 motif 3; other site 767817004402 motif 2; other site 767817004403 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 767817004404 Cell division protein ZapA; Region: ZapA; pfam05164 767817004405 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 767817004406 hypothetical protein; Provisional; Region: PRK08609 767817004407 active site 767817004408 primer binding site [nucleotide binding]; other site 767817004409 NTP binding site [chemical binding]; other site 767817004410 metal binding triad [ion binding]; metal-binding site 767817004411 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 767817004412 active site 767817004413 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 767817004414 active site 767817004415 DNA binding site [nucleotide binding] 767817004416 Uncharacterized conserved protein [Function unknown]; Region: COG0327 767817004417 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 767817004418 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 767817004419 Peptidase family U32; Region: Peptidase_U32; pfam01136 767817004420 Collagenase; Region: DUF3656; pfam12392 767817004421 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 767817004422 Peptidase family U32; Region: Peptidase_U32; pfam01136 767817004423 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 767817004424 MutS domain III; Region: MutS_III; pfam05192 767817004425 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 767817004426 Walker A/P-loop; other site 767817004427 ATP binding site [chemical binding]; other site 767817004428 Q-loop/lid; other site 767817004429 ABC transporter signature motif; other site 767817004430 Walker B; other site 767817004431 D-loop; other site 767817004432 H-loop/switch region; other site 767817004433 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 767817004434 Smr domain; Region: Smr; pfam01713 767817004435 Transglycosylase; Region: Transgly; pfam00912 767817004436 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 767817004437 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767817004438 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 767817004439 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 767817004440 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 767817004441 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817004442 FeS/SAM binding site; other site 767817004443 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 767817004444 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 767817004445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817004446 Coenzyme A binding pocket [chemical binding]; other site 767817004447 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 767817004448 carbohydrate binding site [chemical binding]; other site 767817004449 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 767817004450 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 767817004451 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 767817004452 active site 767817004453 catalytic site [active] 767817004454 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 767817004455 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 767817004456 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 767817004457 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 767817004458 catalytic site [active] 767817004459 active site 767817004460 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817004461 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 767817004462 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 767817004463 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 767817004464 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 767817004465 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 767817004466 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 767817004467 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 767817004468 active site residues [active] 767817004469 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 767817004470 active site 767817004471 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817004472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817004473 active site 767817004474 phosphorylation site [posttranslational modification] 767817004475 intermolecular recognition site; other site 767817004476 dimerization interface [polypeptide binding]; other site 767817004477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817004478 DNA binding site [nucleotide binding] 767817004479 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817004480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817004481 dimer interface [polypeptide binding]; other site 767817004482 phosphorylation site [posttranslational modification] 767817004483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817004484 ATP binding site [chemical binding]; other site 767817004485 Mg2+ binding site [ion binding]; other site 767817004486 G-X-G motif; other site 767817004487 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 767817004488 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 767817004489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817004490 dimer interface [polypeptide binding]; other site 767817004491 conserved gate region; other site 767817004492 ABC-ATPase subunit interface; other site 767817004493 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 767817004494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817004495 dimer interface [polypeptide binding]; other site 767817004496 conserved gate region; other site 767817004497 putative PBP binding loops; other site 767817004498 ABC-ATPase subunit interface; other site 767817004499 HlyD family secretion protein; Region: HlyD_2; pfam12700 767817004500 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 767817004501 HlyD family secretion protein; Region: HlyD_3; pfam13437 767817004502 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767817004503 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 767817004504 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 767817004505 Walker A/P-loop; other site 767817004506 ATP binding site [chemical binding]; other site 767817004507 Q-loop/lid; other site 767817004508 ABC transporter signature motif; other site 767817004509 Walker B; other site 767817004510 D-loop; other site 767817004511 H-loop/switch region; other site 767817004512 TOBE domain; Region: TOBE_2; pfam08402 767817004513 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 767817004514 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 767817004515 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817004516 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 767817004517 Putative transposase; Region: Y2_Tnp; pfam04986 767817004518 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 767817004519 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 767817004520 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 767817004521 Acyltransferase family; Region: Acyl_transf_3; pfam01757 767817004522 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 767817004523 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 767817004524 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767817004525 catalytic residue [active] 767817004526 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767817004527 MULE transposase domain; Region: MULE; pfam10551 767817004528 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 767817004529 4Fe-4S binding domain; Region: Fer4; pfam00037 767817004530 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 767817004531 4Fe-4S binding domain; Region: Fer4; pfam00037 767817004532 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817004533 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 767817004534 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817004535 4Fe-4S binding domain; Region: Fer4; pfam00037 767817004536 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817004537 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 767817004538 putative active site [active] 767817004539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817004540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817004541 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 767817004542 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 767817004543 Predicted membrane protein [Function unknown]; Region: COG2311 767817004544 Protein of unknown function (DUF418); Region: DUF418; pfam04235 767817004545 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 767817004546 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 767817004547 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 767817004548 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 767817004549 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 767817004550 DNA binding residues [nucleotide binding] 767817004551 dimer interface [polypeptide binding]; other site 767817004552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817004553 S-adenosylmethionine binding site [chemical binding]; other site 767817004554 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817004555 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817004556 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767817004557 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767817004558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767817004559 Probable transposase; Region: OrfB_IS605; pfam01385 767817004560 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767817004561 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 767817004562 Na2 binding site [ion binding]; other site 767817004563 putative substrate binding site 1 [chemical binding]; other site 767817004564 Na binding site 1 [ion binding]; other site 767817004565 putative substrate binding site 2 [chemical binding]; other site 767817004566 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 767817004567 FOG: CBS domain [General function prediction only]; Region: COG0517 767817004568 PAS domain; Region: PAS; smart00091 767817004569 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 767817004570 PAS domain; Region: PAS; smart00091 767817004571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817004572 Walker A motif; other site 767817004573 ATP binding site [chemical binding]; other site 767817004574 Walker B motif; other site 767817004575 arginine finger; other site 767817004576 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817004577 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767817004578 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 767817004579 FAD binding site [chemical binding]; other site 767817004580 homotetramer interface [polypeptide binding]; other site 767817004581 substrate binding pocket [chemical binding]; other site 767817004582 catalytic base [active] 767817004583 AMP-binding domain protein; Validated; Region: PRK08315 767817004584 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817004585 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 767817004586 acyl-activating enzyme (AAE) consensus motif; other site 767817004587 putative AMP binding site [chemical binding]; other site 767817004588 putative active site [active] 767817004589 putative CoA binding site [chemical binding]; other site 767817004590 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 767817004591 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 767817004592 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 767817004593 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817004594 enoyl-CoA hydratase; Provisional; Region: PRK07657 767817004595 substrate binding site [chemical binding]; other site 767817004596 oxyanion hole (OAH) forming residues; other site 767817004597 trimer interface [polypeptide binding]; other site 767817004598 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 767817004599 active site 767817004600 catalytic residues [active] 767817004601 metal binding site [ion binding]; metal-binding site 767817004602 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 767817004603 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 767817004604 acyl-activating enzyme (AAE) consensus motif; other site 767817004605 putative AMP binding site [chemical binding]; other site 767817004606 putative active site [active] 767817004607 putative CoA binding site [chemical binding]; other site 767817004608 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 767817004609 homodimer interface [polypeptide binding]; other site 767817004610 NAD synthetase; Provisional; Region: PRK13980 767817004611 NAD binding pocket [chemical binding]; other site 767817004612 ATP binding pocket [chemical binding]; other site 767817004613 Mg binding site [ion binding]; other site 767817004614 active-site loop [active] 767817004615 hypothetical protein; Validated; Region: PRK00110 767817004616 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 767817004617 active site 767817004618 putative DNA-binding cleft [nucleotide binding]; other site 767817004619 dimer interface [polypeptide binding]; other site 767817004620 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 767817004621 RuvA N terminal domain; Region: RuvA_N; pfam01330 767817004622 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 767817004623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817004624 Walker A motif; other site 767817004625 ATP binding site [chemical binding]; other site 767817004626 Walker B motif; other site 767817004627 arginine finger; other site 767817004628 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 767817004629 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 767817004630 Ligand Binding Site [chemical binding]; other site 767817004631 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 767817004632 Stage II sporulation protein; Region: SpoIID; pfam08486 767817004633 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 767817004634 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 767817004635 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 767817004636 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 767817004637 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 767817004638 Preprotein translocase subunit; Region: YajC; pfam02699 767817004639 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817004640 Zn2+ binding site [ion binding]; other site 767817004641 Mg2+ binding site [ion binding]; other site 767817004642 protein-export membrane protein SecD; Region: secD; TIGR01129 767817004643 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 767817004644 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 767817004645 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 767817004646 Protein export membrane protein; Region: SecD_SecF; pfam02355 767817004647 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 767817004648 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 767817004649 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 767817004650 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 767817004651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817004652 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 767817004653 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 767817004654 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 767817004655 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 767817004656 catalytic residues [active] 767817004657 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 767817004658 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767817004659 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767817004660 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 767817004661 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 767817004662 catalytic triad [active] 767817004663 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 767817004664 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 767817004665 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 767817004666 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 767817004667 SpoVR like protein; Region: SpoVR; pfam04293 767817004668 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767817004669 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767817004670 substrate binding pocket [chemical binding]; other site 767817004671 membrane-bound complex binding site; other site 767817004672 hinge residues; other site 767817004673 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767817004674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817004675 dimer interface [polypeptide binding]; other site 767817004676 conserved gate region; other site 767817004677 putative PBP binding loops; other site 767817004678 ABC-ATPase subunit interface; other site 767817004679 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767817004680 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767817004681 Walker A/P-loop; other site 767817004682 ATP binding site [chemical binding]; other site 767817004683 Q-loop/lid; other site 767817004684 ABC transporter signature motif; other site 767817004685 Walker B; other site 767817004686 D-loop; other site 767817004687 H-loop/switch region; other site 767817004688 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 767817004689 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 767817004690 putative DNA binding site [nucleotide binding]; other site 767817004691 putative homodimer interface [polypeptide binding]; other site 767817004692 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 767817004693 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 767817004694 active site 767817004695 DNA binding site [nucleotide binding] 767817004696 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 767817004697 DNA binding site [nucleotide binding] 767817004698 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 767817004699 nucleotide binding site [chemical binding]; other site 767817004700 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 767817004701 DNA protecting protein DprA; Region: dprA; TIGR00732 767817004702 DNA topoisomerase I; Validated; Region: PRK05582 767817004703 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 767817004704 active site 767817004705 interdomain interaction site; other site 767817004706 putative metal-binding site [ion binding]; other site 767817004707 nucleotide binding site [chemical binding]; other site 767817004708 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 767817004709 domain I; other site 767817004710 DNA binding groove [nucleotide binding] 767817004711 phosphate binding site [ion binding]; other site 767817004712 domain II; other site 767817004713 domain III; other site 767817004714 nucleotide binding site [chemical binding]; other site 767817004715 catalytic site [active] 767817004716 domain IV; other site 767817004717 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 767817004718 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 767817004719 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 767817004720 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 767817004721 Glucose inhibited division protein A; Region: GIDA; pfam01134 767817004722 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 767817004723 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 767817004724 active site 767817004725 Int/Topo IB signature motif; other site 767817004726 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 767817004727 active site 767817004728 HslU subunit interaction site [polypeptide binding]; other site 767817004729 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 767817004730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817004731 Walker A motif; other site 767817004732 ATP binding site [chemical binding]; other site 767817004733 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 767817004734 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 767817004735 transcriptional repressor CodY; Validated; Region: PRK04158 767817004736 CodY GAF-like domain; Region: CodY; pfam06018 767817004737 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 767817004738 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 767817004739 rRNA interaction site [nucleotide binding]; other site 767817004740 S8 interaction site; other site 767817004741 putative laminin-1 binding site; other site 767817004742 elongation factor Ts; Reviewed; Region: tsf; PRK12332 767817004743 UBA/TS-N domain; Region: UBA; pfam00627 767817004744 Elongation factor TS; Region: EF_TS; pfam00889 767817004745 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 767817004746 putative nucleotide binding site [chemical binding]; other site 767817004747 uridine monophosphate binding site [chemical binding]; other site 767817004748 homohexameric interface [polypeptide binding]; other site 767817004749 ribosome recycling factor; Reviewed; Region: frr; PRK00083 767817004750 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 767817004751 hinge region; other site 767817004752 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817004753 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817004754 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 767817004755 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 767817004756 catalytic residue [active] 767817004757 putative FPP diphosphate binding site; other site 767817004758 putative FPP binding hydrophobic cleft; other site 767817004759 dimer interface [polypeptide binding]; other site 767817004760 putative IPP diphosphate binding site; other site 767817004761 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 767817004762 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 767817004763 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 767817004764 Domain of unknown function DUF20; Region: UPF0118; pfam01594 767817004765 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 767817004766 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 767817004767 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 767817004768 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 767817004769 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 767817004770 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 767817004771 active site 767817004772 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 767817004773 protein binding site [polypeptide binding]; other site 767817004774 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 767817004775 putative substrate binding region [chemical binding]; other site 767817004776 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 767817004777 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 767817004778 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 767817004779 prolyl-tRNA synthetase; Provisional; Region: PRK09194 767817004780 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 767817004781 dimer interface [polypeptide binding]; other site 767817004782 motif 1; other site 767817004783 active site 767817004784 motif 2; other site 767817004785 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 767817004786 putative deacylase active site [active] 767817004787 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 767817004788 active site 767817004789 motif 3; other site 767817004790 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 767817004791 anticodon binding site; other site 767817004792 ribosome maturation protein RimP; Reviewed; Region: PRK00092 767817004793 Sm and related proteins; Region: Sm_like; cl00259 767817004794 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 767817004795 putative oligomer interface [polypeptide binding]; other site 767817004796 putative RNA binding site [nucleotide binding]; other site 767817004797 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 767817004798 NusA N-terminal domain; Region: NusA_N; pfam08529 767817004799 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 767817004800 RNA binding site [nucleotide binding]; other site 767817004801 homodimer interface [polypeptide binding]; other site 767817004802 NusA-like KH domain; Region: KH_5; pfam13184 767817004803 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 767817004804 G-X-X-G motif; other site 767817004805 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 767817004806 putative RNA binding cleft [nucleotide binding]; other site 767817004807 Ribosomal protein HS6-type (S12/L30/L7a) [Translation, ribosomal structure and biogenesis]; Region: RPL8A; COG1358 767817004808 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 767817004809 translation initiation factor IF-2; Validated; Region: infB; PRK05306 767817004810 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 767817004811 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 767817004812 G1 box; other site 767817004813 putative GEF interaction site [polypeptide binding]; other site 767817004814 GTP/Mg2+ binding site [chemical binding]; other site 767817004815 Switch I region; other site 767817004816 G2 box; other site 767817004817 G3 box; other site 767817004818 Switch II region; other site 767817004819 G4 box; other site 767817004820 G5 box; other site 767817004821 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 767817004822 Translation-initiation factor 2; Region: IF-2; pfam11987 767817004823 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 767817004824 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 767817004825 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 767817004826 DHH family; Region: DHH; pfam01368 767817004827 DHHA1 domain; Region: DHHA1; pfam02272 767817004828 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 767817004829 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 767817004830 RNA binding site [nucleotide binding]; other site 767817004831 active site 767817004832 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 767817004833 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 767817004834 active site 767817004835 Riboflavin kinase; Region: Flavokinase; pfam01687 767817004836 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 767817004837 16S/18S rRNA binding site [nucleotide binding]; other site 767817004838 S13e-L30e interaction site [polypeptide binding]; other site 767817004839 25S rRNA binding site [nucleotide binding]; other site 767817004840 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 767817004841 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 767817004842 RNase E interface [polypeptide binding]; other site 767817004843 trimer interface [polypeptide binding]; other site 767817004844 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 767817004845 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 767817004846 RNase E interface [polypeptide binding]; other site 767817004847 trimer interface [polypeptide binding]; other site 767817004848 active site 767817004849 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 767817004850 putative nucleic acid binding region [nucleotide binding]; other site 767817004851 G-X-X-G motif; other site 767817004852 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 767817004853 RNA binding site [nucleotide binding]; other site 767817004854 domain interface; other site 767817004855 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 767817004856 NodB motif; other site 767817004857 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 767817004858 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 767817004859 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 767817004860 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 767817004861 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 767817004862 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767817004863 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 767817004864 trimer interface [polypeptide binding]; other site 767817004865 active site 767817004866 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 767817004867 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 767817004868 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 767817004869 active site 767817004870 dihydrodipicolinate reductase; Provisional; Region: PRK00048 767817004871 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 767817004872 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 767817004873 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 767817004874 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 767817004875 NAD(P) binding pocket [chemical binding]; other site 767817004876 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 767817004877 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 767817004878 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 767817004879 aspartate kinase I; Reviewed; Region: PRK08210 767817004880 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 767817004881 nucleotide binding site [chemical binding]; other site 767817004882 substrate binding site [chemical binding]; other site 767817004883 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 767817004884 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 767817004885 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 767817004886 dihydrodipicolinate synthase; Region: dapA; TIGR00674 767817004887 dimer interface [polypeptide binding]; other site 767817004888 active site 767817004889 catalytic residue [active] 767817004890 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 767817004891 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767817004892 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 767817004893 Clp protease; Region: CLP_protease; pfam00574 767817004894 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 767817004895 active site 767817004896 YlzJ-like protein; Region: YlzJ; pfam14035 767817004897 Bacitracin resistance protein BacA; Region: BacA; pfam02673 767817004898 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 767817004899 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 767817004900 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767817004901 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 767817004902 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 767817004903 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 767817004904 active site residue [active] 767817004905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 767817004906 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 767817004907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817004908 non-specific DNA binding site [nucleotide binding]; other site 767817004909 salt bridge; other site 767817004910 sequence-specific DNA binding site [nucleotide binding]; other site 767817004911 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 767817004912 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 767817004913 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 767817004914 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817004915 FeS/SAM binding site; other site 767817004916 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 767817004917 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 767817004918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817004919 Walker A motif; other site 767817004920 ATP binding site [chemical binding]; other site 767817004921 Walker B motif; other site 767817004922 arginine finger; other site 767817004923 Peptidase family M41; Region: Peptidase_M41; pfam01434 767817004924 Competence-damaged protein; Region: CinA; pfam02464 767817004925 recombinase A; Provisional; Region: recA; PRK09354 767817004926 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 767817004927 hexamer interface [polypeptide binding]; other site 767817004928 Walker A motif; other site 767817004929 ATP binding site [chemical binding]; other site 767817004930 Walker B motif; other site 767817004931 recombination regulator RecX; Reviewed; Region: recX; PRK00117 767817004932 phosphodiesterase; Provisional; Region: PRK12704 767817004933 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817004934 Zn2+ binding site [ion binding]; other site 767817004935 Mg2+ binding site [ion binding]; other site 767817004936 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 767817004937 putative active site [active] 767817004938 metal binding site [ion binding]; metal-binding site 767817004939 homodimer binding site [polypeptide binding]; other site 767817004940 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 767817004941 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 767817004942 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 767817004943 active site 767817004944 dimer interface [polypeptide binding]; other site 767817004945 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 767817004946 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 767817004947 active site 767817004948 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 767817004949 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 767817004950 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767817004951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817004952 homodimer interface [polypeptide binding]; other site 767817004953 catalytic residue [active] 767817004954 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767817004955 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 767817004956 homotrimer interface [polypeptide binding]; other site 767817004957 Walker A motif; other site 767817004958 GTP binding site [chemical binding]; other site 767817004959 Walker B motif; other site 767817004960 cobyric acid synthase; Provisional; Region: PRK00784 767817004961 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 767817004962 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 767817004963 catalytic triad [active] 767817004964 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 767817004965 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 767817004966 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 767817004967 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 767817004968 catalytic triad [active] 767817004969 cobalamin synthase; Reviewed; Region: cobS; PRK00235 767817004970 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 767817004971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767817004972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817004973 homodimer interface [polypeptide binding]; other site 767817004974 catalytic residue [active] 767817004975 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767817004976 catalytic core [active] 767817004977 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 767817004978 Homeodomain-like domain; Region: HTH_23; cl17451 767817004979 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 767817004980 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 767817004981 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 767817004982 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 767817004983 active site 767817004984 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817004985 Coenzyme A binding pocket [chemical binding]; other site 767817004986 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 767817004987 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 767817004988 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 767817004989 B12 binding site [chemical binding]; other site 767817004990 cobalt ligand [ion binding]; other site 767817004991 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 767817004992 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 767817004993 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 767817004994 Walker A; other site 767817004995 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 767817004996 G4 box; other site 767817004997 G5 box; other site 767817004998 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 767817004999 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 767817005000 homodimer interface [polypeptide binding]; other site 767817005001 Walker A motif; other site 767817005002 ATP binding site [chemical binding]; other site 767817005003 hydroxycobalamin binding site [chemical binding]; other site 767817005004 Walker B motif; other site 767817005005 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 767817005006 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 767817005007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 767817005008 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 767817005009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 767817005010 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 767817005011 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 767817005012 dimer interface [polypeptide binding]; other site 767817005013 active site 767817005014 ADP-ribose binding site [chemical binding]; other site 767817005015 nudix motif; other site 767817005016 metal binding site [ion binding]; metal-binding site 767817005017 septum formation inhibitor; Reviewed; Region: minC; PRK00513 767817005018 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 767817005019 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 767817005020 AMP-binding domain protein; Validated; Region: PRK08315 767817005021 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817005022 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 767817005023 acyl-activating enzyme (AAE) consensus motif; other site 767817005024 putative AMP binding site [chemical binding]; other site 767817005025 putative active site [active] 767817005026 putative CoA binding site [chemical binding]; other site 767817005027 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 767817005028 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817005029 acyl-activating enzyme (AAE) consensus motif; other site 767817005030 AMP binding site [chemical binding]; other site 767817005031 active site 767817005032 CoA binding site [chemical binding]; other site 767817005033 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767817005034 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 767817005035 FAD binding site [chemical binding]; other site 767817005036 homotetramer interface [polypeptide binding]; other site 767817005037 substrate binding pocket [chemical binding]; other site 767817005038 catalytic base [active] 767817005039 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 767817005040 Ligand binding site [chemical binding]; other site 767817005041 Electron transfer flavoprotein domain; Region: ETF; pfam01012 767817005042 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 767817005043 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 767817005044 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 767817005045 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 767817005046 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767817005047 Cysteine-rich domain; Region: CCG; pfam02754 767817005048 Cysteine-rich domain; Region: CCG; pfam02754 767817005049 putative acyltransferase; Provisional; Region: PRK05790 767817005050 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 767817005051 dimer interface [polypeptide binding]; other site 767817005052 active site 767817005053 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 767817005054 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 767817005055 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 767817005056 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 767817005057 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817005058 substrate binding site [chemical binding]; other site 767817005059 oxyanion hole (OAH) forming residues; other site 767817005060 trimer interface [polypeptide binding]; other site 767817005061 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 767817005062 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 767817005063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817005064 FeS/SAM binding site; other site 767817005065 Protein of unknown function (DUF964); Region: DUF964; pfam06133 767817005066 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 767817005067 MutS domain I; Region: MutS_I; pfam01624 767817005068 MutS domain II; Region: MutS_II; pfam05188 767817005069 MutS domain III; Region: MutS_III; pfam05192 767817005070 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 767817005071 Walker A/P-loop; other site 767817005072 ATP binding site [chemical binding]; other site 767817005073 Q-loop/lid; other site 767817005074 ABC transporter signature motif; other site 767817005075 Walker B; other site 767817005076 D-loop; other site 767817005077 H-loop/switch region; other site 767817005078 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 767817005079 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 767817005080 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 767817005081 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 767817005082 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 767817005083 active site 767817005084 Zn binding site [ion binding]; other site 767817005085 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 767817005086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817005087 ATP binding site [chemical binding]; other site 767817005088 Mg2+ binding site [ion binding]; other site 767817005089 G-X-G motif; other site 767817005090 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 767817005091 ATP binding site [chemical binding]; other site 767817005092 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 767817005093 ribosomal biogenesis protein; Validated; Region: PRK00933 767817005094 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 767817005095 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 767817005096 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 767817005097 bacterial Hfq-like; Region: Hfq; cd01716 767817005098 hexamer interface [polypeptide binding]; other site 767817005099 Sm1 motif; other site 767817005100 RNA binding site [nucleotide binding]; other site 767817005101 Sm2 motif; other site 767817005102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817005103 PAS domain; Region: PAS_9; pfam13426 767817005104 putative active site [active] 767817005105 heme pocket [chemical binding]; other site 767817005106 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 767817005107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817005108 Walker A motif; other site 767817005109 ATP binding site [chemical binding]; other site 767817005110 Walker B motif; other site 767817005111 arginine finger; other site 767817005112 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 767817005113 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817005114 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 767817005115 acyl-activating enzyme (AAE) consensus motif; other site 767817005116 acyl-activating enzyme (AAE) consensus motif; other site 767817005117 putative AMP binding site [chemical binding]; other site 767817005118 putative active site [active] 767817005119 putative CoA binding site [chemical binding]; other site 767817005120 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 767817005121 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 767817005122 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 767817005123 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 767817005124 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 767817005125 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 767817005126 dimer interface [polypeptide binding]; other site 767817005127 PYR/PP interface [polypeptide binding]; other site 767817005128 TPP binding site [chemical binding]; other site 767817005129 substrate binding site [chemical binding]; other site 767817005130 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 767817005131 TPP-binding site; other site 767817005132 4Fe-4S binding domain; Region: Fer4; cl02805 767817005133 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 767817005134 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 767817005135 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 767817005136 Minimal MMP-like domain found in Thermus thermophilus TTHA0227, Acidothermus cellulolyticus ACEL2062 and similar proteins; Region: MMP_TTHA0227_like; cl01577 767817005137 bacterial Hfq-like; Region: Hfq; cd01716 767817005138 hexamer interface [polypeptide binding]; other site 767817005139 Sm1 motif; other site 767817005140 RNA binding site [nucleotide binding]; other site 767817005141 Sm2 motif; other site 767817005142 stage V sporulation protein K; Region: spore_V_K; TIGR02881 767817005143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817005144 Walker A motif; other site 767817005145 ATP binding site [chemical binding]; other site 767817005146 Walker B motif; other site 767817005147 arginine finger; other site 767817005148 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 767817005149 Aluminium resistance protein; Region: Alum_res; pfam06838 767817005150 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767817005151 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767817005152 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 767817005153 putative dimerization interface [polypeptide binding]; other site 767817005154 LexA repressor; Validated; Region: PRK00215 767817005155 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 767817005156 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 767817005157 Catalytic site [active] 767817005158 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 767817005159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817005160 putative active site [active] 767817005161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817005162 Walker A motif; other site 767817005163 ATP binding site [chemical binding]; other site 767817005164 Walker B motif; other site 767817005165 arginine finger; other site 767817005166 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817005167 fumarate hydratase; Provisional; Region: PRK06246 767817005168 Fumarase C-terminus; Region: Fumerase_C; cl00795 767817005169 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 767817005170 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 767817005171 CoA-ligase; Region: Ligase_CoA; pfam00549 767817005172 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 767817005173 CoA binding domain; Region: CoA_binding; smart00881 767817005174 CoA-ligase; Region: Ligase_CoA; pfam00549 767817005175 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 767817005176 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 767817005177 B12 binding site [chemical binding]; other site 767817005178 cobalt ligand [ion binding]; other site 767817005179 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 767817005180 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 767817005181 dimer interface [polypeptide binding]; other site 767817005182 substrate binding site [chemical binding]; other site 767817005183 metal binding site [ion binding]; metal-binding site 767817005184 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 767817005185 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 767817005186 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 767817005187 malate dehydrogenase; Reviewed; Region: PRK06223 767817005188 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 767817005189 NAD(P) binding site [chemical binding]; other site 767817005190 dimer interface [polypeptide binding]; other site 767817005191 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767817005192 substrate binding site [chemical binding]; other site 767817005193 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 767817005194 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 767817005195 active site 767817005196 catalytic residues [active] 767817005197 metal binding site [ion binding]; metal-binding site 767817005198 homodimer binding site [polypeptide binding]; other site 767817005199 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 767817005200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817005201 active site 767817005202 phosphorylation site [posttranslational modification] 767817005203 intermolecular recognition site; other site 767817005204 dimerization interface [polypeptide binding]; other site 767817005205 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 767817005206 DNA binding residues [nucleotide binding] 767817005207 dimerization interface [polypeptide binding]; other site 767817005208 Methyltransferase domain; Region: Methyltransf_23; pfam13489 767817005209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817005210 S-adenosylmethionine binding site [chemical binding]; other site 767817005211 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 767817005212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767817005213 NAD(P) binding site [chemical binding]; other site 767817005214 active site 767817005215 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 767817005216 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 767817005217 active site 767817005218 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 767817005219 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 767817005220 DUF35 OB-fold domain; Region: DUF35; pfam01796 767817005221 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase; Region: dearomat_oah; TIGR03200 767817005222 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817005223 substrate binding site [chemical binding]; other site 767817005224 oxyanion hole (OAH) forming residues; other site 767817005225 trimer interface [polypeptide binding]; other site 767817005226 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 767817005227 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817005228 substrate binding site [chemical binding]; other site 767817005229 oxyanion hole (OAH) forming residues; other site 767817005230 trimer interface [polypeptide binding]; other site 767817005231 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 767817005232 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase; Region: dearomat_had; TIGR03201 767817005233 putative NAD(P) binding site [chemical binding]; other site 767817005234 catalytic Zn binding site [ion binding]; other site 767817005235 structural Zn binding site [ion binding]; other site 767817005236 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 767817005237 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 767817005238 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 767817005239 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 767817005240 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767817005241 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767817005242 Cysteine-rich domain; Region: CCG; pfam02754 767817005243 Cysteine-rich domain; Region: CCG; pfam02754 767817005244 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 767817005245 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817005246 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767817005247 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817005248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817005249 4Fe-4S binding domain; Region: Fer4; pfam00037 767817005250 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817005251 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 767817005252 4Fe-4S binding domain; Region: Fer4; pfam00037 767817005253 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 767817005254 4Fe-4S binding domain; Region: Fer4; pfam00037 767817005255 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 767817005256 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 767817005257 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 767817005258 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 767817005259 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767817005260 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767817005261 Cysteine-rich domain; Region: CCG; pfam02754 767817005262 Cysteine-rich domain; Region: CCG; pfam02754 767817005263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817005264 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 767817005265 4Fe-4S binding domain; Region: Fer4; pfam00037 767817005266 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817005267 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817005268 4Fe-4S binding domain; Region: Fer4_6; pfam12837 767817005269 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817005270 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 767817005271 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767817005272 putative DNA binding site [nucleotide binding]; other site 767817005273 putative Zn2+ binding site [ion binding]; other site 767817005274 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 767817005275 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 767817005276 putative dimer interface [polypeptide binding]; other site 767817005277 [2Fe-2S] cluster binding site [ion binding]; other site 767817005278 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 767817005279 dimer interface [polypeptide binding]; other site 767817005280 [2Fe-2S] cluster binding site [ion binding]; other site 767817005281 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 767817005282 SLBB domain; Region: SLBB; pfam10531 767817005283 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 767817005284 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817005285 catalytic loop [active] 767817005286 iron binding site [ion binding]; other site 767817005287 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817005288 hypothetical protein; Provisional; Region: PRK04164 767817005289 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 767817005290 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817005291 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 767817005292 putative ADP-binding pocket [chemical binding]; other site 767817005293 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 767817005294 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817005295 FeS/SAM binding site; other site 767817005296 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 767817005297 phosphofructokinase; Region: PFK_mixed; TIGR02483 767817005298 active site 767817005299 ADP/pyrophosphate binding site [chemical binding]; other site 767817005300 dimerization interface [polypeptide binding]; other site 767817005301 allosteric effector site; other site 767817005302 fructose-1,6-bisphosphate binding site; other site 767817005303 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 767817005304 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767817005305 Serine hydrolase (FSH1); Region: FSH1; pfam03959 767817005306 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 767817005307 Uncharacterized conserved protein [Function unknown]; Region: COG1615 767817005308 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 767817005309 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 767817005310 nucleotide binding site/active site [active] 767817005311 HIT family signature motif; other site 767817005312 catalytic residue [active] 767817005313 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 767817005314 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 767817005315 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767817005316 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 767817005317 oligomerization interface [polypeptide binding]; other site 767817005318 active site 767817005319 metal binding site [ion binding]; metal-binding site 767817005320 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 767817005321 elongation factor G; Reviewed; Region: PRK12740 767817005322 G1 box; other site 767817005323 putative GEF interaction site [polypeptide binding]; other site 767817005324 GTP/Mg2+ binding site [chemical binding]; other site 767817005325 Switch I region; other site 767817005326 G2 box; other site 767817005327 G3 box; other site 767817005328 Switch II region; other site 767817005329 G4 box; other site 767817005330 G5 box; other site 767817005331 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 767817005332 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 767817005333 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 767817005334 stage V sporulation protein B; Region: spore_V_B; TIGR02900 767817005335 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 767817005336 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 767817005337 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 767817005338 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 767817005339 homodecamer interface [polypeptide binding]; other site 767817005340 GTP cyclohydrolase I; Provisional; Region: PLN03044 767817005341 active site 767817005342 putative catalytic site residues [active] 767817005343 zinc binding site [ion binding]; other site 767817005344 GTP-CH-I/GFRP interaction surface; other site 767817005345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767817005346 TPR motif; other site 767817005347 TPR repeat; Region: TPR_11; pfam13414 767817005348 binding surface 767817005349 TPR repeat; Region: TPR_11; pfam13414 767817005350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767817005351 binding surface 767817005352 TPR motif; other site 767817005353 Tetratricopeptide repeat; Region: TPR_12; pfam13424 767817005354 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 767817005355 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 767817005356 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767817005357 active site 767817005358 catalytic site [active] 767817005359 substrate binding site [chemical binding]; other site 767817005360 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767817005361 DEAD_2; Region: DEAD_2; pfam06733 767817005362 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 767817005363 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 767817005364 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 767817005365 Walker A; other site 767817005366 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 767817005367 Switch II region; other site 767817005368 G4 box; other site 767817005369 G5 box; other site 767817005370 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 767817005371 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767817005372 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767817005373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817005374 S-adenosylmethionine binding site [chemical binding]; other site 767817005375 adenylate kinase; Reviewed; Region: adk; PRK00279 767817005376 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 767817005377 AMP-binding site [chemical binding]; other site 767817005378 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 767817005379 Carbohydrate binding domain; Region: CBM_25; smart01066 767817005380 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 767817005381 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; cl17639 767817005382 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767817005383 Asp23 family; Region: Asp23; pfam03780 767817005384 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 767817005385 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817005386 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 767817005387 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 767817005388 Precorrin-8X methylmutase; Region: CbiC; pfam02570 767817005389 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 767817005390 putative active site [active] 767817005391 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 767817005392 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 767817005393 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 767817005394 active site 767817005395 SAM binding site [chemical binding]; other site 767817005396 homodimer interface [polypeptide binding]; other site 767817005397 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 767817005398 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 767817005399 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 767817005400 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 767817005401 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 767817005402 active site 767817005403 SAM binding site [chemical binding]; other site 767817005404 homodimer interface [polypeptide binding]; other site 767817005405 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 767817005406 active site 767817005407 SAM binding site [chemical binding]; other site 767817005408 homodimer interface [polypeptide binding]; other site 767817005409 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 767817005410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817005411 S-adenosylmethionine binding site [chemical binding]; other site 767817005412 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 767817005413 active site 767817005414 putative homodimer interface [polypeptide binding]; other site 767817005415 SAM binding site [chemical binding]; other site 767817005416 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 767817005417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817005418 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767817005419 Walker A motif; other site 767817005420 ATP binding site [chemical binding]; other site 767817005421 Walker B motif; other site 767817005422 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 767817005423 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 767817005424 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 767817005425 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 767817005426 FAD binding site [chemical binding]; other site 767817005427 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 767817005428 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 767817005429 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817005430 4Fe-4S binding domain; Region: Fer4; pfam00037 767817005431 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 767817005432 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767817005433 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767817005434 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817005435 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817005436 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817005437 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 767817005438 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 767817005439 FAD binding site [chemical binding]; other site 767817005440 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 767817005441 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 767817005442 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817005443 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 767817005444 4Fe-4S binding domain; Region: Fer4; pfam00037 767817005445 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 767817005446 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767817005447 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817005448 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817005449 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817005450 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 767817005451 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767817005452 Cysteine-rich domain; Region: CCG; pfam02754 767817005453 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 767817005454 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 767817005455 FAD binding pocket [chemical binding]; other site 767817005456 FAD binding motif [chemical binding]; other site 767817005457 phosphate binding motif [ion binding]; other site 767817005458 beta-alpha-beta structure motif; other site 767817005459 NAD binding pocket [chemical binding]; other site 767817005460 Iron coordination center [ion binding]; other site 767817005461 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 767817005462 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 767817005463 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 767817005464 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 767817005465 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767817005466 4Fe-4S binding domain; Region: Fer4; pfam00037 767817005467 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 767817005468 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817005469 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817005470 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817005471 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 767817005472 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 767817005473 substrate binding pocket [chemical binding]; other site 767817005474 dimer interface [polypeptide binding]; other site 767817005475 inhibitor binding site; inhibition site 767817005476 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 767817005477 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 767817005478 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 767817005479 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 767817005480 Putative Fe-S cluster; Region: FeS; pfam04060 767817005481 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 767817005482 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 767817005483 Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH)...; Region: ACS_2; cd01917 767817005484 CODH interaction site; other site 767817005485 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 767817005486 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 767817005487 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 767817005488 ACS interaction site; other site 767817005489 CODH interaction site; other site 767817005490 cubane metal cluster (B-cluster) [ion binding]; other site 767817005491 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 767817005492 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 767817005493 P-loop; other site 767817005494 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 767817005495 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 767817005496 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817005497 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817005498 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 767817005499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 767817005500 MoxR-like ATPases [General function prediction only]; Region: COG0714 767817005501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 767817005502 Walker A motif; other site 767817005503 ATP binding site [chemical binding]; other site 767817005504 Walker B motif; other site 767817005505 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 767817005506 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 767817005507 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 767817005508 CoA binding domain; Region: CoA_binding; pfam02629 767817005509 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 767817005510 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 767817005511 inhibitor-cofactor binding pocket; inhibition site 767817005512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817005513 catalytic residue [active] 767817005514 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 767817005515 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 767817005516 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 767817005517 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 767817005518 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 767817005519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817005520 FeS/SAM binding site; other site 767817005521 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 767817005522 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 767817005523 dimer interface [polypeptide binding]; other site 767817005524 active site 767817005525 Schiff base residues; other site 767817005526 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 767817005527 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817005528 FeS/SAM binding site; other site 767817005529 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 767817005530 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 767817005531 diphthine synthase; Region: dph5; TIGR00522 767817005532 active site 767817005533 SAM binding site [chemical binding]; other site 767817005534 homodimer interface [polypeptide binding]; other site 767817005535 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 767817005536 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 767817005537 active site 767817005538 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 767817005539 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 767817005540 domain interfaces; other site 767817005541 active site 767817005542 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 767817005543 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 767817005544 tRNA; other site 767817005545 putative tRNA binding site [nucleotide binding]; other site 767817005546 putative NADP binding site [chemical binding]; other site 767817005547 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 767817005548 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 767817005549 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 767817005550 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 767817005551 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 767817005552 substrate binding pocket [chemical binding]; other site 767817005553 chain length determination region; other site 767817005554 substrate-Mg2+ binding site; other site 767817005555 catalytic residues [active] 767817005556 aspartate-rich region 1; other site 767817005557 active site lid residues [active] 767817005558 aspartate-rich region 2; other site 767817005559 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767817005560 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 767817005561 FtsX-like permease family; Region: FtsX; pfam02687 767817005562 FtsX-like permease family; Region: FtsX; pfam02687 767817005563 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767817005564 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767817005565 Walker A/P-loop; other site 767817005566 ATP binding site [chemical binding]; other site 767817005567 Q-loop/lid; other site 767817005568 ABC transporter signature motif; other site 767817005569 Walker B; other site 767817005570 D-loop; other site 767817005571 H-loop/switch region; other site 767817005572 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817005573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817005574 dimer interface [polypeptide binding]; other site 767817005575 phosphorylation site [posttranslational modification] 767817005576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817005577 ATP binding site [chemical binding]; other site 767817005578 Mg2+ binding site [ion binding]; other site 767817005579 G-X-G motif; other site 767817005580 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817005581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817005582 active site 767817005583 phosphorylation site [posttranslational modification] 767817005584 intermolecular recognition site; other site 767817005585 dimerization interface [polypeptide binding]; other site 767817005586 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817005587 DNA binding site [nucleotide binding] 767817005588 Uncharacterized conserved protein [Function unknown]; Region: COG1633 767817005589 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 767817005590 dinuclear metal binding motif [ion binding]; other site 767817005591 Uncharacterized conserved protein [Function unknown]; Region: COG1739 767817005592 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 767817005593 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 767817005594 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 767817005595 active site 767817005596 DNA polymerase IV; Validated; Region: PRK02406 767817005597 DNA binding site [nucleotide binding] 767817005598 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767817005599 Ligand Binding Site [chemical binding]; other site 767817005600 Restriction endonuclease; Region: Mrr_cat; pfam04471 767817005601 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 767817005602 TPP-binding site [chemical binding]; other site 767817005603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817005604 Coenzyme A binding pocket [chemical binding]; other site 767817005605 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 767817005606 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 767817005607 putative active site [active] 767817005608 catalytic triad [active] 767817005609 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 767817005610 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 767817005611 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 767817005612 dimerization interface [polypeptide binding]; other site 767817005613 ATP binding site [chemical binding]; other site 767817005614 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 767817005615 dimerization interface [polypeptide binding]; other site 767817005616 ATP binding site [chemical binding]; other site 767817005617 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767817005618 Ligand Binding Site [chemical binding]; other site 767817005619 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767817005620 active site 767817005621 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 767817005622 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 767817005623 TM-ABC transporter signature motif; other site 767817005624 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 767817005625 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 767817005626 TM-ABC transporter signature motif; other site 767817005627 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 767817005628 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 767817005629 Walker A/P-loop; other site 767817005630 ATP binding site [chemical binding]; other site 767817005631 Q-loop/lid; other site 767817005632 ABC transporter signature motif; other site 767817005633 Walker B; other site 767817005634 D-loop; other site 767817005635 H-loop/switch region; other site 767817005636 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 767817005637 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 767817005638 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 767817005639 putative ligand binding site [chemical binding]; other site 767817005640 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 767817005641 RNA/DNA hybrid binding site [nucleotide binding]; other site 767817005642 active site 767817005643 Protein of unknown function (DUF456); Region: DUF456; pfam04306 767817005644 Uncharacterized conserved protein [Function unknown]; Region: COG1565 767817005645 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 767817005646 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 767817005647 G1 box; other site 767817005648 putative GEF interaction site [polypeptide binding]; other site 767817005649 GTP/Mg2+ binding site [chemical binding]; other site 767817005650 Switch I region; other site 767817005651 G2 box; other site 767817005652 G3 box; other site 767817005653 Switch II region; other site 767817005654 G4 box; other site 767817005655 G5 box; other site 767817005656 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 767817005657 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 767817005658 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 767817005659 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 767817005660 selenocysteine synthase; Provisional; Region: PRK04311 767817005661 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 767817005662 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 767817005663 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767817005664 catalytic residue [active] 767817005665 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 767817005666 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 767817005667 active site 767817005668 putative substrate binding pocket [chemical binding]; other site 767817005669 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 767817005670 TrkA-N domain; Region: TrkA_N; pfam02254 767817005671 TrkA-C domain; Region: TrkA_C; pfam02080 767817005672 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 767817005673 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 767817005674 CoA binding domain; Region: CoA_binding_2; pfam13380 767817005675 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 767817005676 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 767817005677 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 767817005678 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817005679 FeS/SAM binding site; other site 767817005680 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 767817005681 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 767817005682 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 767817005683 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 767817005684 UbiA prenyltransferase family; Region: UbiA; pfam01040 767817005685 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 767817005686 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 767817005687 substrate binding pocket [chemical binding]; other site 767817005688 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 767817005689 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 767817005690 4Fe-4S binding domain; Region: Fer4; cl02805 767817005691 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767817005692 4Fe-4S binding domain; Region: Fer4_5; pfam12801 767817005693 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 767817005694 alanine racemase; Reviewed; Region: alr; PRK00053 767817005695 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 767817005696 active site 767817005697 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767817005698 dimer interface [polypeptide binding]; other site 767817005699 substrate binding site [chemical binding]; other site 767817005700 catalytic residues [active] 767817005701 Uncharacterized conserved protein [Function unknown]; Region: COG0062 767817005702 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 767817005703 putative substrate binding site [chemical binding]; other site 767817005704 putative ATP binding site [chemical binding]; other site 767817005705 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 767817005706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817005707 active site 767817005708 phosphorylation site [posttranslational modification] 767817005709 intermolecular recognition site; other site 767817005710 dimerization interface [polypeptide binding]; other site 767817005711 LytTr DNA-binding domain; Region: LytTR; smart00850 767817005712 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 767817005713 Histidine kinase; Region: His_kinase; pfam06580 767817005714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817005715 ATP binding site [chemical binding]; other site 767817005716 Mg2+ binding site [ion binding]; other site 767817005717 G-X-G motif; other site 767817005718 acetyl-CoA synthetase; Provisional; Region: PRK00174 767817005719 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817005720 acyl-activating enzyme (AAE) consensus motif; other site 767817005721 AMP binding site [chemical binding]; other site 767817005722 active site 767817005723 CoA binding site [chemical binding]; other site 767817005724 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 767817005725 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 767817005726 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 767817005727 PhoU domain; Region: PhoU; pfam01895 767817005728 PhoU domain; Region: PhoU; pfam01895 767817005729 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 767817005730 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817005731 catalytic loop [active] 767817005732 iron binding site [ion binding]; other site 767817005733 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 767817005734 4Fe-4S binding domain; Region: Fer4; pfam00037 767817005735 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 767817005736 [4Fe-4S] binding site [ion binding]; other site 767817005737 molybdopterin cofactor binding site; other site 767817005738 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 767817005739 molybdopterin cofactor binding site; other site 767817005740 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817005741 catalytic loop [active] 767817005742 iron binding site [ion binding]; other site 767817005743 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 767817005744 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767817005745 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817005746 4Fe-4S binding domain; Region: Fer4; pfam00037 767817005747 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 767817005748 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 767817005749 dimer interface [polypeptide binding]; other site 767817005750 [2Fe-2S] cluster binding site [ion binding]; other site 767817005751 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 767817005752 SLBB domain; Region: SLBB; pfam10531 767817005753 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 767817005754 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 767817005755 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 767817005756 putative dimer interface [polypeptide binding]; other site 767817005757 [2Fe-2S] cluster binding site [ion binding]; other site 767817005758 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 767817005759 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 767817005760 ACT domain-containing protein [General function prediction only]; Region: COG4747 767817005761 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 767817005762 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 767817005763 UGMP family protein; Validated; Region: PRK09604 767817005764 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 767817005765 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 767817005766 putative catalytic site [active] 767817005767 putative metal binding site [ion binding]; other site 767817005768 putative phosphate binding site [ion binding]; other site 767817005769 NAD-dependent deacetylase; Provisional; Region: PRK00481 767817005770 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 767817005771 NAD+ binding site [chemical binding]; other site 767817005772 substrate binding site [chemical binding]; other site 767817005773 Zn binding site [ion binding]; other site 767817005774 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 767817005775 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 767817005776 Uncharacterized conserved protein [Function unknown]; Region: COG5663 767817005777 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 767817005778 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 767817005779 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 767817005780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817005781 catalytic residue [active] 767817005782 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 767817005783 putative ADP-ribose binding site [chemical binding]; other site 767817005784 putative active site [active] 767817005785 Coat F domain; Region: Coat_F; pfam07875 767817005786 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767817005787 4Fe-4S binding domain; Region: Fer4; pfam00037 767817005788 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 767817005789 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817005790 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 767817005791 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817005792 Ferredoxin [Energy production and conversion]; Region: COG1146 767817005793 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 767817005794 Cysteine-rich domain; Region: CCG; pfam02754 767817005795 Cysteine-rich domain; Region: CCG; pfam02754 767817005796 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 767817005797 YcfA-like protein; Region: YcfA; pfam07927 767817005798 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 767817005799 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 767817005800 non-specific DNA binding site [nucleotide binding]; other site 767817005801 salt bridge; other site 767817005802 sequence-specific DNA binding site [nucleotide binding]; other site 767817005803 HPP family; Region: HPP; pfam04982 767817005804 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 767817005805 CoenzymeA binding site [chemical binding]; other site 767817005806 subunit interaction site [polypeptide binding]; other site 767817005807 PHB binding site; other site 767817005808 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 767817005809 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767817005810 active site 767817005811 metal binding site [ion binding]; metal-binding site 767817005812 homotetramer interface [polypeptide binding]; other site 767817005813 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 767817005814 active site 767817005815 dimerization interface [polypeptide binding]; other site 767817005816 ribonuclease PH; Reviewed; Region: rph; PRK00173 767817005817 Ribonuclease PH; Region: RNase_PH_bact; cd11362 767817005818 hexamer interface [polypeptide binding]; other site 767817005819 active site 767817005820 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 767817005821 Bacterial SH3 domain; Region: SH3_3; pfam08239 767817005822 Bacterial SH3 domain; Region: SH3_3; pfam08239 767817005823 Bacterial SH3 domain homologues; Region: SH3b; smart00287 767817005824 Bacterial SH3 domain homologues; Region: SH3b; smart00287 767817005825 Bacterial SH3 domain; Region: SH3_3; pfam08239 767817005826 AMIN domain; Region: AMIN; pfam11741 767817005827 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 767817005828 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 767817005829 active site 767817005830 metal binding site [ion binding]; metal-binding site 767817005831 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767817005832 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767817005833 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 767817005834 Sporulation and spore germination; Region: Germane; pfam10646 767817005835 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 767817005836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 767817005837 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767817005838 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 767817005839 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 767817005840 SCP-2 sterol transfer family; Region: SCP2; pfam02036 767817005841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 767817005842 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 767817005843 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 767817005844 hydroxylamine reductase; Provisional; Region: PRK12310 767817005845 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 767817005846 cubane metal cluster [ion binding]; other site 767817005847 hybrid metal cluster; other site 767817005848 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 767817005849 CotJB protein; Region: CotJB; pfam12652 767817005850 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 767817005851 dimanganese center [ion binding]; other site 767817005852 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 767817005853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817005854 dimerization interface [polypeptide binding]; other site 767817005855 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 767817005856 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 767817005857 dimer interface [polypeptide binding]; other site 767817005858 putative CheW interface [polypeptide binding]; other site 767817005859 Transposase domain (DUF772); Region: DUF772; pfam05598 767817005860 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767817005861 flagellar motor switch protein; Validated; Region: PRK08119 767817005862 CheC-like family; Region: CheC; pfam04509 767817005863 Chemotaxis phosphatase CheX; Region: CheX; cl15816 767817005864 flagellar motor switch protein FliN; Region: fliN; TIGR02480 767817005865 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 767817005866 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 767817005867 Response regulator receiver domain; Region: Response_reg; pfam00072 767817005868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817005869 active site 767817005870 phosphorylation site [posttranslational modification] 767817005871 intermolecular recognition site; other site 767817005872 dimerization interface [polypeptide binding]; other site 767817005873 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 767817005874 CheC-like family; Region: CheC; pfam04509 767817005875 CheC-like family; Region: CheC; pfam04509 767817005876 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 767817005877 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 767817005878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817005879 S-adenosylmethionine binding site [chemical binding]; other site 767817005880 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488 767817005881 flagellar basal-body rod protein FlgG, Gram-negative bacteria; Region: flgG_G_neg; TIGR02488 767817005882 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 767817005883 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 767817005884 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 767817005885 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 767817005886 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 767817005887 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817005888 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 767817005889 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817005890 DNA binding residues [nucleotide binding] 767817005891 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 767817005892 Flagellar protein YcgR; Region: YcgR_2; pfam12945 767817005893 PilZ domain; Region: PilZ; pfam07238 767817005894 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 767817005895 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 767817005896 P-loop; other site 767817005897 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 767817005898 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 767817005899 FHIPEP family; Region: FHIPEP; pfam00771 767817005900 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 767817005901 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 767817005902 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 767817005903 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 767817005904 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 767817005905 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 767817005906 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 767817005907 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 767817005908 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 767817005909 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 767817005910 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 767817005911 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 767817005912 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 767817005913 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 767817005914 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 767817005915 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 767817005916 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 767817005917 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 767817005918 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 767817005919 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 767817005920 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 767817005921 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 767817005922 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 767817005923 Walker A motif/ATP binding site; other site 767817005924 Walker B motif; other site 767817005925 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 767817005926 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 767817005927 Flagellar assembly protein FliH; Region: FliH; pfam02108 767817005928 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 767817005929 FliG C-terminal domain; Region: FliG_C; pfam01706 767817005930 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 767817005931 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 767817005932 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 767817005933 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 767817005934 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 767817005935 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 767817005936 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 767817005937 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 767817005938 FlaG protein; Region: FlaG; pfam03646 767817005939 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 767817005940 oligomer interface [polypeptide binding]; other site 767817005941 Flagellar protein FliS; Region: FliS; cl00654 767817005942 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 767817005943 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 767817005944 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 767817005945 N-acetyl-D-glucosamine binding site [chemical binding]; other site 767817005946 catalytic residue [active] 767817005947 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 767817005948 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 767817005949 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817005950 Zn2+ binding site [ion binding]; other site 767817005951 Mg2+ binding site [ion binding]; other site 767817005952 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 767817005953 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 767817005954 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 767817005955 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 767817005956 dimer interface [polypeptide binding]; other site 767817005957 putative CheW interface [polypeptide binding]; other site 767817005958 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 767817005959 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 767817005960 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 767817005961 active site 767817005962 NTP binding site [chemical binding]; other site 767817005963 metal binding triad [ion binding]; metal-binding site 767817005964 antibiotic binding site [chemical binding]; other site 767817005965 Protein of unknown function DUF86; Region: DUF86; cl01031 767817005966 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 767817005967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 767817005968 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 767817005969 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 767817005970 putative active site [active] 767817005971 Putative motility protein; Region: YjfB_motility; pfam14070 767817005972 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 767817005973 active site 767817005974 NTP binding site [chemical binding]; other site 767817005975 metal binding triad [ion binding]; metal-binding site 767817005976 antibiotic binding site [chemical binding]; other site 767817005977 Uncharacterized conserved protein [Function unknown]; Region: COG2361 767817005978 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 767817005979 Protein of unknown function (DUF342); Region: DUF342; pfam03961 767817005980 RelB antitoxin; Region: RelB; cl01171 767817005981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 767817005982 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 767817005983 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 767817005984 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 767817005985 HNH endonuclease; Region: HNH_5; pfam14279 767817005986 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 767817005987 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 767817005988 Global regulator protein family; Region: CsrA; pfam02599 767817005989 flagellar assembly protein FliW; Provisional; Region: PRK13285 767817005990 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 767817005991 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 767817005992 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 767817005993 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 767817005994 FlgN protein; Region: FlgN; pfam05130 767817005995 FlaG protein; Region: FlaG; cl00591 767817005996 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 767817005997 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 767817005998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817005999 active site 767817006000 phosphorylation site [posttranslational modification] 767817006001 intermolecular recognition site; other site 767817006002 dimerization interface [polypeptide binding]; other site 767817006003 CheB methylesterase; Region: CheB_methylest; pfam01339 767817006004 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 767817006005 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 767817006006 putative binding surface; other site 767817006007 active site 767817006008 P2 response regulator binding domain; Region: P2; pfam07194 767817006009 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 767817006010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817006011 ATP binding site [chemical binding]; other site 767817006012 Mg2+ binding site [ion binding]; other site 767817006013 G-X-G motif; other site 767817006014 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 767817006015 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 767817006016 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 767817006017 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 767817006018 flagellar motor protein MotS; Reviewed; Region: PRK06925 767817006019 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 767817006020 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 767817006021 ligand binding site [chemical binding]; other site 767817006022 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 767817006023 S-layer homology domain; Region: SLH; pfam00395 767817006024 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 767817006025 Na binding site [ion binding]; other site 767817006026 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 767817006027 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 767817006028 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 767817006029 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817006030 putative active site [active] 767817006031 heme pocket [chemical binding]; other site 767817006032 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817006033 putative active site [active] 767817006034 heme pocket [chemical binding]; other site 767817006035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817006036 Walker A motif; other site 767817006037 ATP binding site [chemical binding]; other site 767817006038 Walker B motif; other site 767817006039 arginine finger; other site 767817006040 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 767817006041 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 767817006042 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 767817006043 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 767817006044 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 767817006045 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 767817006046 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 767817006047 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 767817006048 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 767817006049 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 767817006050 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 767817006051 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 767817006052 homodimer interface [polypeptide binding]; other site 767817006053 substrate-cofactor binding pocket; other site 767817006054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817006055 catalytic residue [active] 767817006056 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 767817006057 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 767817006058 chorismate binding enzyme; Region: Chorismate_bind; cl10555 767817006059 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 767817006060 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 767817006061 glutamine binding [chemical binding]; other site 767817006062 catalytic triad [active] 767817006063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 767817006064 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 767817006065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 767817006066 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 767817006067 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767817006068 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 767817006069 Walker A/P-loop; other site 767817006070 ATP binding site [chemical binding]; other site 767817006071 Q-loop/lid; other site 767817006072 ABC transporter signature motif; other site 767817006073 Walker B; other site 767817006074 D-loop; other site 767817006075 H-loop/switch region; other site 767817006076 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817006077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817006078 active site 767817006079 phosphorylation site [posttranslational modification] 767817006080 intermolecular recognition site; other site 767817006081 dimerization interface [polypeptide binding]; other site 767817006082 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817006083 DNA binding site [nucleotide binding] 767817006084 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817006085 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817006086 dimer interface [polypeptide binding]; other site 767817006087 phosphorylation site [posttranslational modification] 767817006088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817006089 ATP binding site [chemical binding]; other site 767817006090 Mg2+ binding site [ion binding]; other site 767817006091 G-X-G motif; other site 767817006092 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 767817006093 putative active site [active] 767817006094 Transposase [DNA replication, recombination, and repair]; Region: COG5421 767817006095 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 767817006096 putative active site [active] 767817006097 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 767817006098 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 767817006099 metal-binding site [ion binding] 767817006100 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767817006101 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767817006102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767817006103 dimerization interface [polypeptide binding]; other site 767817006104 putative DNA binding site [nucleotide binding]; other site 767817006105 putative Zn2+ binding site [ion binding]; other site 767817006106 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 767817006107 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 767817006108 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 767817006109 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 767817006110 putative deacylase active site [active] 767817006111 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817006112 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817006113 dimerization interface [polypeptide binding]; other site 767817006114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817006115 dimer interface [polypeptide binding]; other site 767817006116 phosphorylation site [posttranslational modification] 767817006117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817006118 ATP binding site [chemical binding]; other site 767817006119 Mg2+ binding site [ion binding]; other site 767817006120 G-X-G motif; other site 767817006121 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817006122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817006123 active site 767817006124 phosphorylation site [posttranslational modification] 767817006125 intermolecular recognition site; other site 767817006126 dimerization interface [polypeptide binding]; other site 767817006127 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817006128 DNA binding site [nucleotide binding] 767817006129 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 767817006130 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 767817006131 protein binding site [polypeptide binding]; other site 767817006132 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 767817006133 FMN binding site [chemical binding]; other site 767817006134 dimer interface [polypeptide binding]; other site 767817006135 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 767817006136 active site 767817006137 8-oxo-dGMP binding site [chemical binding]; other site 767817006138 nudix motif; other site 767817006139 metal binding site [ion binding]; metal-binding site 767817006140 Rubrerythrin [Energy production and conversion]; Region: COG1592 767817006141 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 767817006142 binuclear metal center [ion binding]; other site 767817006143 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 767817006144 iron binding site [ion binding]; other site 767817006145 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 767817006146 metal binding site 2 [ion binding]; metal-binding site 767817006147 putative DNA binding helix; other site 767817006148 metal binding site 1 [ion binding]; metal-binding site 767817006149 dimer interface [polypeptide binding]; other site 767817006150 structural Zn2+ binding site [ion binding]; other site 767817006151 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 767817006152 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817006153 acyl-activating enzyme (AAE) consensus motif; other site 767817006154 AMP binding site [chemical binding]; other site 767817006155 active site 767817006156 CoA binding site [chemical binding]; other site 767817006157 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 767817006158 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817006159 substrate binding site [chemical binding]; other site 767817006160 oxyanion hole (OAH) forming residues; other site 767817006161 trimer interface [polypeptide binding]; other site 767817006162 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 767817006163 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 767817006164 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 767817006165 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 767817006166 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 767817006167 active site 767817006168 metal-binding site [ion binding] 767817006169 nucleotide-binding site [chemical binding]; other site 767817006170 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767817006171 MULE transposase domain; Region: MULE; pfam10551 767817006172 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767817006173 NlpC/P60 family; Region: NLPC_P60; pfam00877 767817006174 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767817006175 NlpC/P60 family; Region: NLPC_P60; pfam00877 767817006176 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767817006177 NlpC/P60 family; Region: NLPC_P60; cl17555 767817006178 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767817006179 NlpC/P60 family; Region: NLPC_P60; pfam00877 767817006180 NlpC/P60 family; Region: NLPC_P60; pfam00877 767817006181 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817006182 HAMP domain; Region: HAMP; pfam00672 767817006183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817006184 dimer interface [polypeptide binding]; other site 767817006185 phosphorylation site [posttranslational modification] 767817006186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817006187 ATP binding site [chemical binding]; other site 767817006188 Mg2+ binding site [ion binding]; other site 767817006189 G-X-G motif; other site 767817006190 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817006191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817006192 active site 767817006193 phosphorylation site [posttranslational modification] 767817006194 intermolecular recognition site; other site 767817006195 dimerization interface [polypeptide binding]; other site 767817006196 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817006197 DNA binding site [nucleotide binding] 767817006198 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817006199 SCP-2 sterol transfer family; Region: SCP2; pfam02036 767817006200 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 767817006201 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767817006202 putative active site [active] 767817006203 putative metal binding site [ion binding]; other site 767817006204 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 767817006205 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 767817006206 putative homodimer interface [polypeptide binding]; other site 767817006207 putative homotetramer interface [polypeptide binding]; other site 767817006208 putative allosteric switch controlling residues; other site 767817006209 putative metal binding site [ion binding]; other site 767817006210 putative homodimer-homodimer interface [polypeptide binding]; other site 767817006211 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 767817006212 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 767817006213 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767817006214 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 767817006215 Protein of unknown function (DUF867); Region: DUF867; pfam05908 767817006216 Protein of unknown function (DUF867); Region: DUF867; pfam05908 767817006217 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767817006218 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767817006219 Walker A/P-loop; other site 767817006220 ATP binding site [chemical binding]; other site 767817006221 Q-loop/lid; other site 767817006222 ABC transporter signature motif; other site 767817006223 Walker B; other site 767817006224 D-loop; other site 767817006225 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 767817006226 H-loop/switch region; other site 767817006227 metal binding site [ion binding]; metal-binding site 767817006228 Putative zinc-finger; Region: zf-HC2; pfam13490 767817006229 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 767817006230 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 767817006231 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817006232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817006233 DNA binding residues [nucleotide binding] 767817006234 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 767817006235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817006236 Coenzyme A binding pocket [chemical binding]; other site 767817006237 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 767817006238 Glycoprotease family; Region: Peptidase_M22; pfam00814 767817006239 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 767817006240 Response regulator receiver domain; Region: Response_reg; pfam00072 767817006241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817006242 active site 767817006243 phosphorylation site [posttranslational modification] 767817006244 intermolecular recognition site; other site 767817006245 dimerization interface [polypeptide binding]; other site 767817006246 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 767817006247 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 767817006248 active site 767817006249 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 767817006250 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 767817006251 catalytic triad [active] 767817006252 PemK-like protein; Region: PemK; pfam02452 767817006253 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 767817006254 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 767817006255 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 767817006256 putative valine binding site [chemical binding]; other site 767817006257 dimer interface [polypeptide binding]; other site 767817006258 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 767817006259 glutamine synthetase, type I; Region: GlnA; TIGR00653 767817006260 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 767817006261 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 767817006262 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 767817006263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817006264 active site 767817006265 phosphorylation site [posttranslational modification] 767817006266 intermolecular recognition site; other site 767817006267 dimerization interface [polypeptide binding]; other site 767817006268 ANTAR domain; Region: ANTAR; pfam03861 767817006269 glutamate dehydrogenase; Provisional; Region: PRK09414 767817006270 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 767817006271 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 767817006272 NAD(P) binding site [chemical binding]; other site 767817006273 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 767817006274 Transcriptional regulator [Transcription]; Region: IclR; COG1414 767817006275 Bacterial transcriptional regulator; Region: IclR; pfam01614 767817006276 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 767817006277 active site 767817006278 FMN binding site [chemical binding]; other site 767817006279 substrate binding site [chemical binding]; other site 767817006280 3Fe-4S cluster binding site [ion binding]; other site 767817006281 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 767817006282 Transcriptional regulator [Transcription]; Region: IclR; COG1414 767817006283 Bacterial transcriptional regulator; Region: IclR; pfam01614 767817006284 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 767817006285 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 767817006286 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 767817006287 catalytic residues [active] 767817006288 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 767817006289 putative CheW interface [polypeptide binding]; other site 767817006290 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 767817006291 active site 767817006292 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 767817006293 dimer interface [polypeptide binding]; other site 767817006294 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 767817006295 Ligand Binding Site [chemical binding]; other site 767817006296 Molecular Tunnel; other site 767817006297 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 767817006298 putative subunit interface; other site 767817006299 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767817006300 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 767817006301 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 767817006302 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 767817006303 active site 767817006304 FMN binding site [chemical binding]; other site 767817006305 substrate binding site [chemical binding]; other site 767817006306 3Fe-4S cluster binding site [ion binding]; other site 767817006307 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 767817006308 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 767817006309 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 767817006310 putative active site [active] 767817006311 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 767817006312 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767817006313 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 767817006314 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817006315 Zn2+ binding site [ion binding]; other site 767817006316 Mg2+ binding site [ion binding]; other site 767817006317 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 767817006318 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 767817006319 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 767817006320 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 767817006321 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 767817006322 cobalamin binding residues [chemical binding]; other site 767817006323 putative BtuC binding residues; other site 767817006324 dimer interface [polypeptide binding]; other site 767817006325 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 767817006326 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 767817006327 Walker A/P-loop; other site 767817006328 ATP binding site [chemical binding]; other site 767817006329 Q-loop/lid; other site 767817006330 ABC transporter signature motif; other site 767817006331 Walker B; other site 767817006332 D-loop; other site 767817006333 H-loop/switch region; other site 767817006334 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 767817006335 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 767817006336 dimer interface [polypeptide binding]; other site 767817006337 putative PBP binding regions; other site 767817006338 ABC-ATPase subunit interface; other site 767817006339 hypothetical protein; Provisional; Region: PRK06851 767817006340 hypothetical protein; Provisional; Region: PRK06761 767817006341 Predicted amidohydrolase [General function prediction only]; Region: COG0388 767817006342 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 767817006343 putative active site [active] 767817006344 catalytic triad [active] 767817006345 putative dimer interface [polypeptide binding]; other site 767817006346 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13647 767817006347 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767817006348 Walker A/P-loop; other site 767817006349 ATP binding site [chemical binding]; other site 767817006350 Q-loop/lid; other site 767817006351 ABC transporter signature motif; other site 767817006352 Walker B; other site 767817006353 D-loop; other site 767817006354 H-loop/switch region; other site 767817006355 Cobalt transport protein; Region: CbiQ; cl00463 767817006356 cobalt transport protein CbiN; Provisional; Region: PRK02898 767817006357 cobalt transport protein CbiM; Validated; Region: PRK08319 767817006358 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 767817006359 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 767817006360 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 767817006361 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 767817006362 TatD related DNase; Region: TatD_DNase; pfam01026 767817006363 active site 767817006364 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 767817006365 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817006366 ATP binding site [chemical binding]; other site 767817006367 putative Mg++ binding site [ion binding]; other site 767817006368 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817006369 nucleotide binding region [chemical binding]; other site 767817006370 ATP-binding site [chemical binding]; other site 767817006371 RQC domain; Region: RQC; pfam09382 767817006372 HRDC domain; Region: HRDC; pfam00570 767817006373 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 767817006374 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817006375 NlpC/P60 family; Region: NLPC_P60; pfam00877 767817006376 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 767817006377 nudix motif; other site 767817006378 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817006379 Zn2+ binding site [ion binding]; other site 767817006380 Mg2+ binding site [ion binding]; other site 767817006381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 767817006382 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 767817006383 Flavoprotein; Region: Flavoprotein; pfam02441 767817006384 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 767817006385 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817006386 acyl-activating enzyme (AAE) consensus motif; other site 767817006387 AMP binding site [chemical binding]; other site 767817006388 active site 767817006389 CoA binding site [chemical binding]; other site 767817006390 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 767817006391 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 767817006392 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 767817006393 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 767817006394 hypothetical protein; Provisional; Region: PRK08296 767817006395 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 767817006396 Activator of aromatic catabolism; Region: XylR_N; pfam06505 767817006397 V4R domain; Region: V4R; pfam02830 767817006398 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 767817006399 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 767817006400 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 767817006401 trimer interface [polypeptide binding]; other site 767817006402 putative metal binding site [ion binding]; other site 767817006403 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 767817006404 CoenzymeA binding site [chemical binding]; other site 767817006405 subunit interaction site [polypeptide binding]; other site 767817006406 PHB binding site; other site 767817006407 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767817006408 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 767817006409 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 767817006410 dimer interface [polypeptide binding]; other site 767817006411 active site 767817006412 citrylCoA binding site [chemical binding]; other site 767817006413 Citrate synthase; Region: Citrate_synt; pfam00285 767817006414 oxalacetate/citrate binding site [chemical binding]; other site 767817006415 coenzyme A binding site [chemical binding]; other site 767817006416 catalytic triad [active] 767817006417 sporulation sigma factor SigK; Reviewed; Region: PRK05803 767817006418 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817006419 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817006420 DNA binding residues [nucleotide binding] 767817006421 Fic family protein [Function unknown]; Region: COG3177 767817006422 Fic/DOC family; Region: Fic; pfam02661 767817006423 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 767817006424 Predicted membrane protein [Function unknown]; Region: COG4129 767817006425 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 767817006426 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112 767817006427 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 767817006428 dimer interface [polypeptide binding]; other site 767817006429 [2Fe-2S] cluster binding site [ion binding]; other site 767817006430 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817006431 Radical SAM superfamily; Region: Radical_SAM; pfam04055 767817006432 FeS/SAM binding site; other site 767817006433 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 767817006434 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 767817006435 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 767817006436 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 767817006437 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 767817006438 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 767817006439 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 767817006440 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 767817006441 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 767817006442 Nitrogen regulatory protein P-II; Region: P-II; smart00938 767817006443 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 767817006444 Nitrogen regulatory protein P-II; Region: P-II; smart00938 767817006445 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 767817006446 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 767817006447 Nucleotide-binding sites [chemical binding]; other site 767817006448 Walker A motif; other site 767817006449 Switch I region of nucleotide binding site; other site 767817006450 Fe4S4 binding sites [ion binding]; other site 767817006451 Switch II region of nucleotide binding site; other site 767817006452 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 767817006453 active site 767817006454 catalytic residues [active] 767817006455 metal binding site [ion binding]; metal-binding site 767817006456 NAD synthetase; Provisional; Region: PRK13981 767817006457 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 767817006458 multimer interface [polypeptide binding]; other site 767817006459 active site 767817006460 catalytic triad [active] 767817006461 protein interface 1 [polypeptide binding]; other site 767817006462 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 767817006463 homodimer interface [polypeptide binding]; other site 767817006464 NAD binding pocket [chemical binding]; other site 767817006465 ATP binding pocket [chemical binding]; other site 767817006466 Mg binding site [ion binding]; other site 767817006467 active-site loop [active] 767817006468 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 767817006469 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 767817006470 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767817006471 catalytic residue [active] 767817006472 S-layer homology domain; Region: SLH; pfam00395 767817006473 S-layer homology domain; Region: SLH; pfam00395 767817006474 Domain of unknown function DUF39; Region: DUF39; pfam01837 767817006475 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 767817006476 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817006477 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817006478 hypothetical protein; Provisional; Region: PRK04334 767817006479 acyl-CoA synthetase; Validated; Region: PRK08162 767817006480 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 767817006481 acyl-activating enzyme (AAE) consensus motif; other site 767817006482 putative active site [active] 767817006483 AMP binding site [chemical binding]; other site 767817006484 putative CoA binding site [chemical binding]; other site 767817006485 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 767817006486 active site 767817006487 catalytic triad [active] 767817006488 oxyanion hole [active] 767817006489 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 767817006490 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 767817006491 pyruvate kinase; Provisional; Region: PRK06354 767817006492 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 767817006493 domain interfaces; other site 767817006494 active site 767817006495 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 767817006496 6-phosphofructokinase; Provisional; Region: PRK03202 767817006497 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 767817006498 active site 767817006499 ADP/pyrophosphate binding site [chemical binding]; other site 767817006500 dimerization interface [polypeptide binding]; other site 767817006501 allosteric effector site; other site 767817006502 fructose-1,6-bisphosphate binding site; other site 767817006503 transcription attenuation protein MtrB; Provisional; Region: PRK13251 767817006504 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 767817006505 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 767817006506 active site 767817006507 PHP Thumb interface [polypeptide binding]; other site 767817006508 metal binding site [ion binding]; metal-binding site 767817006509 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 767817006510 generic binding surface II; other site 767817006511 generic binding surface I; other site 767817006512 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 767817006513 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 767817006514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817006515 putative active site [active] 767817006516 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817006517 putative active site [active] 767817006518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817006519 Walker A motif; other site 767817006520 ATP binding site [chemical binding]; other site 767817006521 Walker B motif; other site 767817006522 arginine finger; other site 767817006523 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817006524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817006525 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767817006526 Walker A motif; other site 767817006527 ATP binding site [chemical binding]; other site 767817006528 Walker B motif; other site 767817006529 arginine finger; other site 767817006530 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 767817006531 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 767817006532 endonuclease III; Region: ENDO3c; smart00478 767817006533 minor groove reading motif; other site 767817006534 helix-hairpin-helix signature motif; other site 767817006535 substrate binding pocket [chemical binding]; other site 767817006536 active site 767817006537 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 767817006538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 767817006539 Uncharacterized conserved protein [Function unknown]; Region: COG1543 767817006540 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 767817006541 active site 767817006542 substrate binding site [chemical binding]; other site 767817006543 catalytic site [active] 767817006544 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 767817006545 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 767817006546 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 767817006547 active site 767817006548 Substrate binding site; other site 767817006549 Mg++ binding site; other site 767817006550 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 767817006551 putative trimer interface [polypeptide binding]; other site 767817006552 putative CoA binding site [chemical binding]; other site 767817006553 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 767817006554 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 767817006555 active site 767817006556 substrate binding site [chemical binding]; other site 767817006557 metal binding site [ion binding]; metal-binding site 767817006558 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817006559 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767817006560 Carbohydrate binding domain; Region: CBM_25; smart01066 767817006561 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 767817006562 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 767817006563 active site 767817006564 catalytic residues [active] 767817006565 metal binding site [ion binding]; metal-binding site 767817006566 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 767817006567 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 767817006568 GatB domain; Region: GatB_Yqey; smart00845 767817006569 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 767817006570 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 767817006571 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 767817006572 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 767817006573 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 767817006574 nucleotide binding pocket [chemical binding]; other site 767817006575 K-X-D-G motif; other site 767817006576 catalytic site [active] 767817006577 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 767817006578 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 767817006579 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 767817006580 Dimer interface [polypeptide binding]; other site 767817006581 BRCT sequence motif; other site 767817006582 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 767817006583 Part of AAA domain; Region: AAA_19; pfam13245 767817006584 Family description; Region: UvrD_C_2; pfam13538 767817006585 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 767817006586 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 767817006587 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 767817006588 substrate binding site [chemical binding]; other site 767817006589 glutamase interaction surface [polypeptide binding]; other site 767817006590 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 767817006591 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 767817006592 catalytic residues [active] 767817006593 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 767817006594 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 767817006595 putative active site [active] 767817006596 oxyanion strand; other site 767817006597 catalytic triad [active] 767817006598 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 767817006599 putative active site pocket [active] 767817006600 4-fold oligomerization interface [polypeptide binding]; other site 767817006601 metal binding residues [ion binding]; metal-binding site 767817006602 3-fold/trimer interface [polypeptide binding]; other site 767817006603 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 767817006604 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767817006605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817006606 homodimer interface [polypeptide binding]; other site 767817006607 catalytic residue [active] 767817006608 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 767817006609 histidinol dehydrogenase; Region: hisD; TIGR00069 767817006610 NAD binding site [chemical binding]; other site 767817006611 dimerization interface [polypeptide binding]; other site 767817006612 product binding site; other site 767817006613 substrate binding site [chemical binding]; other site 767817006614 zinc binding site [ion binding]; other site 767817006615 catalytic residues [active] 767817006616 Trp repressor protein; Region: Trp_repressor; cl17266 767817006617 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 767817006618 putative active site [active] 767817006619 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 767817006620 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767817006621 MULE transposase domain; Region: MULE; pfam10551 767817006622 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767817006623 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767817006624 Probable transposase; Region: OrfB_IS605; pfam01385 767817006625 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767817006626 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767817006627 PAS fold; Region: PAS_4; pfam08448 767817006628 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817006629 putative active site [active] 767817006630 heme pocket [chemical binding]; other site 767817006631 PAS domain S-box; Region: sensory_box; TIGR00229 767817006632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817006633 putative active site [active] 767817006634 heme pocket [chemical binding]; other site 767817006635 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 767817006636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817006637 putative active site [active] 767817006638 heme pocket [chemical binding]; other site 767817006639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817006640 dimer interface [polypeptide binding]; other site 767817006641 phosphorylation site [posttranslational modification] 767817006642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817006643 ATP binding site [chemical binding]; other site 767817006644 Mg2+ binding site [ion binding]; other site 767817006645 G-X-G motif; other site 767817006646 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 767817006647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817006648 active site 767817006649 phosphorylation site [posttranslational modification] 767817006650 intermolecular recognition site; other site 767817006651 dimerization interface [polypeptide binding]; other site 767817006652 LytTr DNA-binding domain; Region: LytTR; smart00850 767817006653 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 767817006654 Accessory gene regulator B; Region: AgrB; pfam04647 767817006655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817006656 ATP binding site [chemical binding]; other site 767817006657 Mg2+ binding site [ion binding]; other site 767817006658 G-X-G motif; other site 767817006659 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 767817006660 PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301 767817006661 nucleic acid-binding interface [nucleotide binding]; other site 767817006662 transposase/IS protein; Provisional; Region: PRK09183 767817006663 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817006664 Walker A motif; other site 767817006665 ATP binding site [chemical binding]; other site 767817006666 Walker B motif; other site 767817006667 arginine finger; other site 767817006668 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 767817006669 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 767817006670 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 767817006671 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 767817006672 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 767817006673 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 767817006674 purine monophosphate binding site [chemical binding]; other site 767817006675 dimer interface [polypeptide binding]; other site 767817006676 putative catalytic residues [active] 767817006677 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 767817006678 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 767817006679 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 767817006680 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 767817006681 active site 767817006682 substrate binding site [chemical binding]; other site 767817006683 cosubstrate binding site; other site 767817006684 catalytic site [active] 767817006685 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 767817006686 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 767817006687 dimerization interface [polypeptide binding]; other site 767817006688 putative ATP binding site [chemical binding]; other site 767817006689 amidophosphoribosyltransferase; Provisional; Region: PRK05793 767817006690 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 767817006691 active site 767817006692 tetramer interface [polypeptide binding]; other site 767817006693 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767817006694 active site 767817006695 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 767817006696 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 767817006697 ATP binding site [chemical binding]; other site 767817006698 active site 767817006699 substrate binding site [chemical binding]; other site 767817006700 adenylosuccinate lyase; Provisional; Region: PRK07492 767817006701 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 767817006702 tetramer interface [polypeptide binding]; other site 767817006703 active site 767817006704 AIR carboxylase; Region: AIRC; pfam00731 767817006705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 767817006706 non-specific DNA binding site [nucleotide binding]; other site 767817006707 salt bridge; other site 767817006708 sequence-specific DNA binding site [nucleotide binding]; other site 767817006709 Fic family protein [Function unknown]; Region: COG3177 767817006710 Fic/DOC family; Region: Fic; pfam02661 767817006711 GMP synthase; Reviewed; Region: guaA; PRK00074 767817006712 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 767817006713 AMP/PPi binding site [chemical binding]; other site 767817006714 candidate oxyanion hole; other site 767817006715 catalytic triad [active] 767817006716 potential glutamine specificity residues [chemical binding]; other site 767817006717 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 767817006718 ATP Binding subdomain [chemical binding]; other site 767817006719 Ligand Binding sites [chemical binding]; other site 767817006720 Dimerization subdomain; other site 767817006721 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767817006722 active site 767817006723 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 767817006724 homodimer interface [polypeptide binding]; other site 767817006725 metal binding site [ion binding]; metal-binding site 767817006726 Uncharacterized conserved protein [Function unknown]; Region: COG4198 767817006727 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 767817006728 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 767817006729 ABC1 family; Region: ABC1; pfam03109 767817006730 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 767817006731 active site 767817006732 ATP binding site [chemical binding]; other site 767817006733 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 767817006734 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767817006735 ligand binding site [chemical binding]; other site 767817006736 flexible hinge region; other site 767817006737 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 767817006738 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 767817006739 metal binding triad; other site 767817006740 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767817006741 active site 767817006742 catalytic site [active] 767817006743 substrate binding site [chemical binding]; other site 767817006744 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 767817006745 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 767817006746 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 767817006747 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817006748 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767817006749 Walker A/P-loop; other site 767817006750 ATP binding site [chemical binding]; other site 767817006751 Q-loop/lid; other site 767817006752 ABC transporter signature motif; other site 767817006753 Walker B; other site 767817006754 D-loop; other site 767817006755 H-loop/switch region; other site 767817006756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817006757 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 767817006758 dimer interface [polypeptide binding]; other site 767817006759 conserved gate region; other site 767817006760 putative PBP binding loops; other site 767817006761 ABC-ATPase subunit interface; other site 767817006762 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 767817006763 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 767817006764 Helix-turn-helix domain; Region: HTH_17; pfam12728 767817006765 PBP superfamily domain; Region: PBP_like; pfam12727 767817006766 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 767817006767 Uncharacterized conserved protein [Function unknown]; Region: COG2006 767817006768 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817006769 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817006770 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817006771 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 767817006772 Predicted integral membrane protein [Function unknown]; Region: COG5658 767817006773 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 767817006774 SdpI/YhfL protein family; Region: SdpI; pfam13630 767817006775 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767817006776 dimerization interface [polypeptide binding]; other site 767817006777 putative DNA binding site [nucleotide binding]; other site 767817006778 putative Zn2+ binding site [ion binding]; other site 767817006779 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 767817006780 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 767817006781 aspartate kinase; Reviewed; Region: PRK06635 767817006782 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 767817006783 putative catalytic residues [active] 767817006784 putative nucleotide binding site [chemical binding]; other site 767817006785 putative aspartate binding site [chemical binding]; other site 767817006786 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 767817006787 putative allosteric regulatory site; other site 767817006788 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 767817006789 putative allosteric regulatory residue; other site 767817006790 homoserine kinase; Provisional; Region: PRK01212 767817006791 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767817006792 homoserine dehydrogenase; Provisional; Region: PRK06349 767817006793 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 767817006794 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 767817006795 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 767817006796 hypothetical protein; Provisional; Region: PRK04435 767817006797 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 767817006798 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 767817006799 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 767817006800 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 767817006801 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 767817006802 trimer interface [polypeptide binding]; other site 767817006803 putative metal binding site [ion binding]; other site 767817006804 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 767817006805 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 767817006806 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 767817006807 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 767817006808 GTP-binding protein Der; Reviewed; Region: PRK00093 767817006809 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 767817006810 G1 box; other site 767817006811 GTP/Mg2+ binding site [chemical binding]; other site 767817006812 Switch I region; other site 767817006813 G2 box; other site 767817006814 Switch II region; other site 767817006815 G3 box; other site 767817006816 G4 box; other site 767817006817 G5 box; other site 767817006818 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 767817006819 G1 box; other site 767817006820 GTP/Mg2+ binding site [chemical binding]; other site 767817006821 Switch I region; other site 767817006822 G2 box; other site 767817006823 G3 box; other site 767817006824 Switch II region; other site 767817006825 G4 box; other site 767817006826 G5 box; other site 767817006827 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 767817006828 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 767817006829 Protein of unknown function (DUF512); Region: DUF512; pfam04459 767817006830 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 767817006831 YIEGIA protein; Region: YIEGIA; pfam14045 767817006832 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 767817006833 stage II sporulation protein P; Region: spore_II_P; TIGR02867 767817006834 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 767817006835 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 767817006836 LytB protein; Region: LYTB; cl00507 767817006837 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 767817006838 RNA binding site [nucleotide binding]; other site 767817006839 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 767817006840 RNA binding site [nucleotide binding]; other site 767817006841 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 767817006842 RNA binding site [nucleotide binding]; other site 767817006843 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 767817006844 RNA binding site [nucleotide binding]; other site 767817006845 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 767817006846 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 767817006847 putative acyl-acceptor binding pocket; other site 767817006848 cytidylate kinase; Provisional; Region: cmk; PRK00023 767817006849 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 767817006850 CMP-binding site; other site 767817006851 The sites determining sugar specificity; other site 767817006852 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 767817006853 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 767817006854 hinge; other site 767817006855 active site 767817006856 prephenate dehydrogenase; Validated; Region: PRK08507 767817006857 Prephenate dehydrogenase; Region: PDH; pfam02153 767817006858 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 767817006859 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 767817006860 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 767817006861 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 767817006862 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 767817006863 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 767817006864 homotrimer interaction site [polypeptide binding]; other site 767817006865 active site 767817006866 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 767817006867 hexamer interface [polypeptide binding]; other site 767817006868 RNA binding site [nucleotide binding]; other site 767817006869 Histidine-zinc binding site [chemical binding]; other site 767817006870 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 767817006871 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767817006872 RNA binding surface [nucleotide binding]; other site 767817006873 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 767817006874 active site 767817006875 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 767817006876 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 767817006877 Glucose inhibited division protein A; Region: GIDA; pfam01134 767817006878 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 767817006879 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 767817006880 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 767817006881 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 767817006882 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 767817006883 active site 767817006884 HIGH motif; other site 767817006885 dimer interface [polypeptide binding]; other site 767817006886 KMSKS motif; other site 767817006887 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 767817006888 Peptidase family M50; Region: Peptidase_M50; pfam02163 767817006889 active site 767817006890 putative substrate binding region [chemical binding]; other site 767817006891 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 767817006892 DHH family; Region: DHH; pfam01368 767817006893 FOG: CBS domain [General function prediction only]; Region: COG0517 767817006894 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 767817006895 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 767817006896 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 767817006897 active site 767817006898 NTP binding site [chemical binding]; other site 767817006899 metal binding triad [ion binding]; metal-binding site 767817006900 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 767817006901 diaminopimelate decarboxylase; Region: lysA; TIGR01048 767817006902 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 767817006903 active site 767817006904 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767817006905 substrate binding site [chemical binding]; other site 767817006906 catalytic residues [active] 767817006907 dimer interface [polypeptide binding]; other site 767817006908 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 767817006909 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 767817006910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817006911 catalytic residue [active] 767817006912 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 767817006913 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767817006914 nucleotide binding site [chemical binding]; other site 767817006915 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 767817006916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 767817006917 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 767817006918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 767817006919 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 767817006920 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 767817006921 Dodecin; Region: Dodecin; pfam07311 767817006922 sporulation sigma factor SigF; Validated; Region: PRK05572 767817006923 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817006924 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 767817006925 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817006926 DNA binding residues [nucleotide binding] 767817006927 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 767817006928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817006929 ATP binding site [chemical binding]; other site 767817006930 Mg2+ binding site [ion binding]; other site 767817006931 G-X-G motif; other site 767817006932 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 767817006933 anti sigma factor interaction site; other site 767817006934 regulatory phosphorylation site [posttranslational modification]; other site 767817006935 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 767817006936 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 767817006937 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 767817006938 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 767817006939 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 767817006940 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 767817006941 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 767817006942 phosphopentomutase; Provisional; Region: PRK05362 767817006943 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 767817006944 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 767817006945 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 767817006946 active site 767817006947 Int/Topo IB signature motif; other site 767817006948 Integral membrane protein DUF95; Region: DUF95; cl00572 767817006949 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 767817006950 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 767817006951 peptidase T-like protein; Region: PepT-like; TIGR01883 767817006952 metal binding site [ion binding]; metal-binding site 767817006953 putative dimer interface [polypeptide binding]; other site 767817006954 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 767817006955 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 767817006956 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 767817006957 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 767817006958 TPP-binding site [chemical binding]; other site 767817006959 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 767817006960 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 767817006961 dimer interface [polypeptide binding]; other site 767817006962 PYR/PP interface [polypeptide binding]; other site 767817006963 TPP binding site [chemical binding]; other site 767817006964 substrate binding site [chemical binding]; other site 767817006965 Ferredoxin [Energy production and conversion]; Region: COG1146 767817006966 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817006967 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 767817006968 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 767817006969 Mg++ binding site [ion binding]; other site 767817006970 putative catalytic motif [active] 767817006971 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 767817006972 Ligand binding site; other site 767817006973 Putative Catalytic site; other site 767817006974 DXD motif; other site 767817006975 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 767817006976 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 767817006977 Thiamine pyrophosphokinase; Region: TPK; cl08415 767817006978 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 767817006979 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 767817006980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817006981 active site 767817006982 phosphorylation site [posttranslational modification] 767817006983 intermolecular recognition site; other site 767817006984 dimerization interface [polypeptide binding]; other site 767817006985 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 767817006986 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 767817006987 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 767817006988 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 767817006989 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 767817006990 Walker A/P-loop; other site 767817006991 ATP binding site [chemical binding]; other site 767817006992 Q-loop/lid; other site 767817006993 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 767817006994 ABC transporter signature motif; other site 767817006995 Walker B; other site 767817006996 D-loop; other site 767817006997 H-loop/switch region; other site 767817006998 Arginine repressor [Transcription]; Region: ArgR; COG1438 767817006999 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 767817007000 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 767817007001 Methyltransferase domain; Region: Methyltransf_31; pfam13847 767817007002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817007003 S-adenosylmethionine binding site [chemical binding]; other site 767817007004 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 767817007005 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 767817007006 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 767817007007 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767817007008 RNA binding surface [nucleotide binding]; other site 767817007009 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 767817007010 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 767817007011 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 767817007012 TPP-binding site; other site 767817007013 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 767817007014 PYR/PP interface [polypeptide binding]; other site 767817007015 dimer interface [polypeptide binding]; other site 767817007016 TPP binding site [chemical binding]; other site 767817007017 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767817007018 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 767817007019 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 767817007020 substrate binding pocket [chemical binding]; other site 767817007021 chain length determination region; other site 767817007022 substrate-Mg2+ binding site; other site 767817007023 catalytic residues [active] 767817007024 aspartate-rich region 1; other site 767817007025 active site lid residues [active] 767817007026 aspartate-rich region 2; other site 767817007027 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 767817007028 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 767817007029 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 767817007030 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 767817007031 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 767817007032 homodimer interface [polypeptide binding]; other site 767817007033 NADP binding site [chemical binding]; other site 767817007034 substrate binding site [chemical binding]; other site 767817007035 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 767817007036 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 767817007037 generic binding surface II; other site 767817007038 generic binding surface I; other site 767817007039 putative oxidoreductase; Provisional; Region: PRK12831 767817007040 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767817007041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817007042 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 767817007043 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 767817007044 FAD binding pocket [chemical binding]; other site 767817007045 FAD binding motif [chemical binding]; other site 767817007046 phosphate binding motif [ion binding]; other site 767817007047 beta-alpha-beta structure motif; other site 767817007048 NAD binding pocket [chemical binding]; other site 767817007049 Iron coordination center [ion binding]; other site 767817007050 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 767817007051 putative RNA binding site [nucleotide binding]; other site 767817007052 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 767817007053 Asp23 family; Region: Asp23; pfam03780 767817007054 Asp23 family; Region: Asp23; pfam03780 767817007055 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 767817007056 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767817007057 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 767817007058 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 767817007059 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 767817007060 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 767817007061 active site 767817007062 catalytic residues [active] 767817007063 metal binding site [ion binding]; metal-binding site 767817007064 homodimer binding site [polypeptide binding]; other site 767817007065 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 767817007066 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 767817007067 carboxyltransferase (CT) interaction site; other site 767817007068 biotinylation site [posttranslational modification]; other site 767817007069 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 767817007070 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 767817007071 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 767817007072 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 767817007073 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 767817007074 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 767817007075 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 767817007076 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 767817007077 NTPase; Region: NTPase_1; cl17478 767817007078 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 767817007079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767817007080 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767817007081 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767817007082 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 767817007083 active site residue [active] 767817007084 elongation factor P; Validated; Region: PRK00529 767817007085 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 767817007086 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 767817007087 RNA binding site [nucleotide binding]; other site 767817007088 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 767817007089 RNA binding site [nucleotide binding]; other site 767817007090 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 767817007091 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 767817007092 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 767817007093 active site 767817007094 Dehydroquinase class II; Region: DHquinase_II; pfam01220 767817007095 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 767817007096 trimer interface [polypeptide binding]; other site 767817007097 active site 767817007098 dimer interface [polypeptide binding]; other site 767817007099 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 767817007100 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 767817007101 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 767817007102 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 767817007103 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 767817007104 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 767817007105 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 767817007106 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 767817007107 Na binding site [ion binding]; other site 767817007108 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 767817007109 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 767817007110 acyl-activating enzyme (AAE) consensus motif; other site 767817007111 putative AMP binding site [chemical binding]; other site 767817007112 putative active site [active] 767817007113 putative CoA binding site [chemical binding]; other site 767817007114 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 767817007115 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 767817007116 acyl-activating enzyme (AAE) consensus motif; other site 767817007117 putative AMP binding site [chemical binding]; other site 767817007118 putative active site [active] 767817007119 putative CoA binding site [chemical binding]; other site 767817007120 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 767817007121 active site 1 [active] 767817007122 dimer interface [polypeptide binding]; other site 767817007123 hexamer interface [polypeptide binding]; other site 767817007124 active site 2 [active] 767817007125 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 767817007126 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767817007127 hexokinase; Provisional; Region: PTZ00107 767817007128 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767817007129 nucleotide binding site [chemical binding]; other site 767817007130 Hexokinase; Region: Hexokinase_2; pfam03727 767817007131 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 767817007132 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 767817007133 tetramer interface [polypeptide binding]; other site 767817007134 active site 767817007135 Mg2+/Mn2+ binding site [ion binding]; other site 767817007136 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 767817007137 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 767817007138 substrate binding site [chemical binding]; other site 767817007139 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 767817007140 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 767817007141 substrate binding site [chemical binding]; other site 767817007142 ligand binding site [chemical binding]; other site 767817007143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 767817007144 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 767817007145 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 767817007146 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 767817007147 Pilus assembly protein, PilO; Region: PilO; cl01234 767817007148 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 767817007149 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 767817007150 Cell division protein FtsA; Region: FtsA; cl17206 767817007151 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 767817007152 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 767817007153 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 767817007154 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 767817007155 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 767817007156 Walker A motif; other site 767817007157 ATP binding site [chemical binding]; other site 767817007158 Walker B motif; other site 767817007159 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 767817007160 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 767817007161 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 767817007162 Walker A motif; other site 767817007163 ATP binding site [chemical binding]; other site 767817007164 Walker B motif; other site 767817007165 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 767817007166 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 767817007167 active site 767817007168 dimer interface [polypeptide binding]; other site 767817007169 metal binding site [ion binding]; metal-binding site 767817007170 shikimate kinase; Provisional; Region: PRK13947 767817007171 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 767817007172 ADP binding site [chemical binding]; other site 767817007173 magnesium binding site [ion binding]; other site 767817007174 putative shikimate binding site; other site 767817007175 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 767817007176 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 767817007177 Tetramer interface [polypeptide binding]; other site 767817007178 active site 767817007179 FMN-binding site [chemical binding]; other site 767817007180 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 767817007181 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 767817007182 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 767817007183 shikimate binding site; other site 767817007184 NAD(P) binding site [chemical binding]; other site 767817007185 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 767817007186 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767817007187 active site 767817007188 motif I; other site 767817007189 motif II; other site 767817007190 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 767817007191 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 767817007192 GTP binding site; other site 767817007193 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 767817007194 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817007195 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817007196 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767817007197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817007198 non-specific DNA binding site [nucleotide binding]; other site 767817007199 salt bridge; other site 767817007200 sequence-specific DNA binding site [nucleotide binding]; other site 767817007201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817007202 non-specific DNA binding site [nucleotide binding]; other site 767817007203 salt bridge; other site 767817007204 sequence-specific DNA binding site [nucleotide binding]; other site 767817007205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817007206 non-specific DNA binding site [nucleotide binding]; other site 767817007207 salt bridge; other site 767817007208 sequence-specific DNA binding site [nucleotide binding]; other site 767817007209 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 767817007210 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 767817007211 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 767817007212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817007213 FeS/SAM binding site; other site 767817007214 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 767817007215 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 767817007216 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767817007217 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767817007218 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 767817007219 Peptidase family U32; Region: Peptidase_U32; pfam01136 767817007220 YceG-like family; Region: YceG; pfam02618 767817007221 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 767817007222 dimerization interface [polypeptide binding]; other site 767817007223 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 767817007224 VanW like protein; Region: VanW; pfam04294 767817007225 G5 domain; Region: G5; pfam07501 767817007226 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 767817007227 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767817007228 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767817007229 active site 767817007230 catalytic tetrad [active] 767817007231 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817007232 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817007233 hypothetical protein; Provisional; Region: PRK05473 767817007234 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 767817007235 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 767817007236 motif 1; other site 767817007237 active site 767817007238 motif 2; other site 767817007239 motif 3; other site 767817007240 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 767817007241 DHHA1 domain; Region: DHHA1; pfam02272 767817007242 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 767817007243 Domain of unknown function DUF20; Region: UPF0118; pfam01594 767817007244 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 767817007245 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 767817007246 Ligand Binding Site [chemical binding]; other site 767817007247 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 767817007248 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 767817007249 trimerization site [polypeptide binding]; other site 767817007250 active site 767817007251 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 767817007252 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 767817007253 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767817007254 catalytic residue [active] 767817007255 Predicted transcriptional regulator [Transcription]; Region: COG1959 767817007256 Transcriptional regulator; Region: Rrf2; cl17282 767817007257 recombination factor protein RarA; Reviewed; Region: PRK13342 767817007258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817007259 Walker A motif; other site 767817007260 ATP binding site [chemical binding]; other site 767817007261 Walker B motif; other site 767817007262 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 767817007263 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767817007264 catalytic residues [active] 767817007265 Transposase [DNA replication, recombination, and repair]; Region: COG5421 767817007266 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 767817007267 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 767817007268 putative ATP binding site [chemical binding]; other site 767817007269 putative substrate interface [chemical binding]; other site 767817007270 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 767817007271 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 767817007272 dimer interface [polypeptide binding]; other site 767817007273 anticodon binding site; other site 767817007274 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 767817007275 homodimer interface [polypeptide binding]; other site 767817007276 motif 1; other site 767817007277 active site 767817007278 motif 2; other site 767817007279 GAD domain; Region: GAD; pfam02938 767817007280 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 767817007281 motif 3; other site 767817007282 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 767817007283 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 767817007284 dimer interface [polypeptide binding]; other site 767817007285 motif 1; other site 767817007286 active site 767817007287 motif 2; other site 767817007288 motif 3; other site 767817007289 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 767817007290 anticodon binding site; other site 767817007291 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 767817007292 acetyl-CoA synthetase; Provisional; Region: PRK04319 767817007293 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817007294 acyl-activating enzyme (AAE) consensus motif; other site 767817007295 AMP binding site [chemical binding]; other site 767817007296 active site 767817007297 CoA binding site [chemical binding]; other site 767817007298 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 767817007299 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767817007300 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 767817007301 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817007302 Zn2+ binding site [ion binding]; other site 767817007303 Mg2+ binding site [ion binding]; other site 767817007304 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 767817007305 synthetase active site [active] 767817007306 NTP binding site [chemical binding]; other site 767817007307 metal binding site [ion binding]; metal-binding site 767817007308 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 767817007309 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 767817007310 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 767817007311 DHH family; Region: DHH; pfam01368 767817007312 DHHA1 domain; Region: DHHA1; pfam02272 767817007313 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767817007314 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767817007315 Cysteine-rich domain; Region: CCG; pfam02754 767817007316 Cysteine-rich domain; Region: CCG; pfam02754 767817007317 FAD binding domain; Region: FAD_binding_4; pfam01565 767817007318 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 767817007319 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 767817007320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817007321 Walker A/P-loop; other site 767817007322 ATP binding site [chemical binding]; other site 767817007323 Q-loop/lid; other site 767817007324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817007325 ABC transporter signature motif; other site 767817007326 Walker B; other site 767817007327 D-loop; other site 767817007328 H-loop/switch region; other site 767817007329 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 767817007330 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 767817007331 active site 767817007332 metal binding site [ion binding]; metal-binding site 767817007333 DNA binding site [nucleotide binding] 767817007334 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 767817007335 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767817007336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767817007337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767817007338 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 767817007339 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 767817007340 TrkA-C domain; Region: TrkA_C; pfam02080 767817007341 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 767817007342 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 767817007343 active site 767817007344 FMN binding site [chemical binding]; other site 767817007345 substrate binding site [chemical binding]; other site 767817007346 putative catalytic residue [active] 767817007347 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767817007348 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767817007349 Probable zinc-binding domain; Region: zf-trcl; pfam13451 767817007350 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 767817007351 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 767817007352 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 767817007353 acyl-activating enzyme (AAE) consensus motif; other site 767817007354 putative AMP binding site [chemical binding]; other site 767817007355 putative active site [active] 767817007356 putative CoA binding site [chemical binding]; other site 767817007357 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 767817007358 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 767817007359 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 767817007360 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 767817007361 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 767817007362 dimer interface [polypeptide binding]; other site 767817007363 active site 767817007364 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 767817007365 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767817007366 active site 767817007367 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 767817007368 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817007369 substrate binding site [chemical binding]; other site 767817007370 oxyanion hole (OAH) forming residues; other site 767817007371 trimer interface [polypeptide binding]; other site 767817007372 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 767817007373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817007374 active site 767817007375 phosphorylation site [posttranslational modification] 767817007376 intermolecular recognition site; other site 767817007377 dimerization interface [polypeptide binding]; other site 767817007378 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 767817007379 DNA binding residues [nucleotide binding] 767817007380 dimerization interface [polypeptide binding]; other site 767817007381 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 767817007382 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 767817007383 G1 box; other site 767817007384 putative GEF interaction site [polypeptide binding]; other site 767817007385 GTP/Mg2+ binding site [chemical binding]; other site 767817007386 Switch I region; other site 767817007387 G2 box; other site 767817007388 G3 box; other site 767817007389 Switch II region; other site 767817007390 G4 box; other site 767817007391 G5 box; other site 767817007392 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 767817007393 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 767817007394 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 767817007395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817007396 Walker A motif; other site 767817007397 ATP binding site [chemical binding]; other site 767817007398 Walker B motif; other site 767817007399 arginine finger; other site 767817007400 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 767817007401 Acylphosphatase; Region: Acylphosphatase; cl00551 767817007402 hypothetical protein; Reviewed; Region: PRK12497 767817007403 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 767817007404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 767817007405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817007406 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767817007407 Walker A motif; other site 767817007408 ATP binding site [chemical binding]; other site 767817007409 Walker B motif; other site 767817007410 arginine finger; other site 767817007411 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 767817007412 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 767817007413 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 767817007414 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 767817007415 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 767817007416 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 767817007417 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 767817007418 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 767817007419 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 767817007420 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 767817007421 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 767817007422 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817007423 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 767817007424 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 767817007425 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 767817007426 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 767817007427 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 767817007428 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 767817007429 NADH dehydrogenase subunit B; Validated; Region: PRK06411 767817007430 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 767817007431 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 767817007432 RNA/DNA hybrid binding site [nucleotide binding]; other site 767817007433 active site 767817007434 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 767817007435 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 767817007436 GTP/Mg2+ binding site [chemical binding]; other site 767817007437 G4 box; other site 767817007438 G5 box; other site 767817007439 G1 box; other site 767817007440 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 767817007441 G1 box; other site 767817007442 Switch I region; other site 767817007443 G2 box; other site 767817007444 G2 box; other site 767817007445 G3 box; other site 767817007446 G3 box; other site 767817007447 Switch II region; other site 767817007448 Switch II region; other site 767817007449 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 767817007450 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 767817007451 Catalytic site [active] 767817007452 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 767817007453 stage II sporulation protein P; Region: spore_II_P; TIGR02867 767817007454 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817007455 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817007456 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 767817007457 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 767817007458 RimM N-terminal domain; Region: RimM; pfam01782 767817007459 PRC-barrel domain; Region: PRC; pfam05239 767817007460 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 767817007461 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 767817007462 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 767817007463 signal recognition particle protein; Provisional; Region: PRK10867 767817007464 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 767817007465 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 767817007466 P loop; other site 767817007467 GTP binding site [chemical binding]; other site 767817007468 Signal peptide binding domain; Region: SRP_SPB; pfam02978 767817007469 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 767817007470 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817007471 DNA binding residues [nucleotide binding] 767817007472 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 767817007473 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 767817007474 inhibitor-cofactor binding pocket; inhibition site 767817007475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817007476 catalytic residue [active] 767817007477 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 767817007478 Uncharacterized conserved protein [Function unknown]; Region: COG2445 767817007479 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 767817007480 active site 767817007481 NTP binding site [chemical binding]; other site 767817007482 metal binding triad [ion binding]; metal-binding site 767817007483 antibiotic binding site [chemical binding]; other site 767817007484 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 767817007485 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 767817007486 ACS interaction site; other site 767817007487 CODH interaction site; other site 767817007488 cubane metal cluster (B-cluster) [ion binding]; other site 767817007489 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 767817007490 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 767817007491 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 767817007492 active site 767817007493 putative substrate binding pocket [chemical binding]; other site 767817007494 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 767817007495 intersubunit interface [polypeptide binding]; other site 767817007496 active site 767817007497 Zn2+ binding site [ion binding]; other site 767817007498 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 767817007499 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 767817007500 homotetramer interface [polypeptide binding]; other site 767817007501 ligand binding site [chemical binding]; other site 767817007502 catalytic site [active] 767817007503 NAD binding site [chemical binding]; other site 767817007504 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 767817007505 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 767817007506 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 767817007507 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 767817007508 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 767817007509 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 767817007510 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 767817007511 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 767817007512 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 767817007513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817007514 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 767817007515 Walker A/P-loop; other site 767817007516 ATP binding site [chemical binding]; other site 767817007517 Q-loop/lid; other site 767817007518 ABC transporter signature motif; other site 767817007519 Walker B; other site 767817007520 D-loop; other site 767817007521 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 767817007522 HlyD family secretion protein; Region: HlyD_3; pfam13437 767817007523 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817007524 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817007525 Transposase domain (DUF772); Region: DUF772; pfam05598 767817007526 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767817007527 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 767817007528 active site 767817007529 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 767817007530 oligomeric interface; other site 767817007531 putative active site [active] 767817007532 homodimer interface [polypeptide binding]; other site 767817007533 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 767817007534 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 767817007535 Cache domain; Region: Cache_1; pfam02743 767817007536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817007537 dimerization interface [polypeptide binding]; other site 767817007538 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 767817007539 dimer interface [polypeptide binding]; other site 767817007540 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 767817007541 putative CheW interface [polypeptide binding]; other site 767817007542 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 767817007543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817007544 dimerization interface [polypeptide binding]; other site 767817007545 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 767817007546 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 767817007547 dimer interface [polypeptide binding]; other site 767817007548 putative CheW interface [polypeptide binding]; other site 767817007549 AAA domain; Region: AAA_28; pfam13521 767817007550 AAA domain; Region: AAA_17; pfam13207 767817007551 Predicted transcriptional regulators [Transcription]; Region: COG1695 767817007552 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767817007553 dimerization interface [polypeptide binding]; other site 767817007554 putative Zn2+ binding site [ion binding]; other site 767817007555 putative DNA binding site [nucleotide binding]; other site 767817007556 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 767817007557 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 767817007558 metal binding site [ion binding]; metal-binding site 767817007559 active site 767817007560 I-site; other site 767817007561 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 767817007562 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 767817007563 4Fe-4S binding domain; Region: Fer4; cl02805 767817007564 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 767817007565 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 767817007566 FAD binding pocket [chemical binding]; other site 767817007567 FAD binding motif [chemical binding]; other site 767817007568 phosphate binding motif [ion binding]; other site 767817007569 beta-alpha-beta structure motif; other site 767817007570 NAD binding pocket [chemical binding]; other site 767817007571 Iron coordination center [ion binding]; other site 767817007572 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 767817007573 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767817007574 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 767817007575 Spore germination protein; Region: Spore_permease; cl17796 767817007576 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 767817007577 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 767817007578 Predicted transcriptional regulators [Transcription]; Region: COG1695 767817007579 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 767817007580 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 767817007581 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 767817007582 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 767817007583 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 767817007584 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 767817007585 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 767817007586 P loop; other site 767817007587 GTP binding site [chemical binding]; other site 767817007588 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 767817007589 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 767817007590 dimerization interface [polypeptide binding]; other site 767817007591 active site 767817007592 metal binding site [ion binding]; metal-binding site 767817007593 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 767817007594 dsRNA binding site [nucleotide binding]; other site 767817007595 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 767817007596 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 767817007597 dimer interface [polypeptide binding]; other site 767817007598 active site 767817007599 acyl carrier protein; Provisional; Region: acpP; PRK00982 767817007600 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 767817007601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767817007602 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 767817007603 NAD(P) binding site [chemical binding]; other site 767817007604 homotetramer interface [polypeptide binding]; other site 767817007605 homodimer interface [polypeptide binding]; other site 767817007606 active site 767817007607 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 767817007608 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 767817007609 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 767817007610 FMN binding site [chemical binding]; other site 767817007611 substrate binding site [chemical binding]; other site 767817007612 putative catalytic residue [active] 767817007613 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 767817007614 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 767817007615 dimer interface [polypeptide binding]; other site 767817007616 active site 767817007617 CoA binding pocket [chemical binding]; other site 767817007618 putative phosphate acyltransferase; Provisional; Region: PRK05331 767817007619 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 767817007620 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 767817007621 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 767817007622 active site 2 [active] 767817007623 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 767817007624 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 767817007625 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 767817007626 Nucleoside recognition; Region: Gate; pfam07670 767817007627 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 767817007628 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 767817007629 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 767817007630 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 767817007631 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 767817007632 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 767817007633 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 767817007634 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 767817007635 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 767817007636 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 767817007637 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 767817007638 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 767817007639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817007640 Walker A motif; other site 767817007641 ATP binding site [chemical binding]; other site 767817007642 Walker B motif; other site 767817007643 arginine finger; other site 767817007644 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 767817007645 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 767817007646 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 767817007647 active site 767817007648 (T/H)XGH motif; other site 767817007649 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 767817007650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817007651 S-adenosylmethionine binding site [chemical binding]; other site 767817007652 germination protease; Provisional; Region: PRK12362 767817007653 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 767817007654 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 767817007655 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 767817007656 generic binding surface II; other site 767817007657 ssDNA binding site; other site 767817007658 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817007659 ATP binding site [chemical binding]; other site 767817007660 putative Mg++ binding site [ion binding]; other site 767817007661 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817007662 nucleotide binding region [chemical binding]; other site 767817007663 ATP-binding site [chemical binding]; other site 767817007664 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 767817007665 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 767817007666 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 767817007667 active site 767817007668 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 767817007669 homopentamer interface [polypeptide binding]; other site 767817007670 active site 767817007671 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 767817007672 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 767817007673 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 767817007674 dimerization interface [polypeptide binding]; other site 767817007675 active site 767817007676 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 767817007677 Lumazine binding domain; Region: Lum_binding; pfam00677 767817007678 Lumazine binding domain; Region: Lum_binding; pfam00677 767817007679 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 767817007680 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 767817007681 catalytic motif [active] 767817007682 Zn binding site [ion binding]; other site 767817007683 RibD C-terminal domain; Region: RibD_C; cl17279 767817007684 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 767817007685 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 767817007686 Walker A/P-loop; other site 767817007687 ATP binding site [chemical binding]; other site 767817007688 Q-loop/lid; other site 767817007689 ABC transporter signature motif; other site 767817007690 Walker B; other site 767817007691 D-loop; other site 767817007692 H-loop/switch region; other site 767817007693 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 767817007694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817007695 dimer interface [polypeptide binding]; other site 767817007696 conserved gate region; other site 767817007697 putative PBP binding loops; other site 767817007698 ABC-ATPase subunit interface; other site 767817007699 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 767817007700 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 767817007701 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 767817007702 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 767817007703 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817007704 acetyl-CoA synthetase; Provisional; Region: PRK00174 767817007705 acyl-activating enzyme (AAE) consensus motif; other site 767817007706 AMP binding site [chemical binding]; other site 767817007707 active site 767817007708 CoA binding site [chemical binding]; other site 767817007709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767817007710 DNA-binding site [nucleotide binding]; DNA binding site 767817007711 TrkA-C domain; Region: TrkA_C; pfam02080 767817007712 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 767817007713 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 767817007714 substrate binding site [chemical binding]; other site 767817007715 hexamer interface [polypeptide binding]; other site 767817007716 metal binding site [ion binding]; metal-binding site 767817007717 GTPase RsgA; Reviewed; Region: PRK00098 767817007718 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 767817007719 RNA binding site [nucleotide binding]; other site 767817007720 homodimer interface [polypeptide binding]; other site 767817007721 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 767817007722 GTPase/Zn-binding domain interface [polypeptide binding]; other site 767817007723 GTP/Mg2+ binding site [chemical binding]; other site 767817007724 G4 box; other site 767817007725 G5 box; other site 767817007726 G1 box; other site 767817007727 Switch I region; other site 767817007728 G2 box; other site 767817007729 G3 box; other site 767817007730 Switch II region; other site 767817007731 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 767817007732 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 767817007733 active site 767817007734 ATP binding site [chemical binding]; other site 767817007735 substrate binding site [chemical binding]; other site 767817007736 activation loop (A-loop); other site 767817007737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 767817007738 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767817007739 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767817007740 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767817007741 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767817007742 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767817007743 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 767817007744 Protein phosphatase 2C; Region: PP2C; pfam00481 767817007745 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 767817007746 active site 767817007747 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 767817007748 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 767817007749 phosphopeptide binding site; other site 767817007750 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 767817007751 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 767817007752 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 767817007753 phosphopeptide binding site; other site 767817007754 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 767817007755 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817007756 FeS/SAM binding site; other site 767817007757 16S rRNA methyltransferase B; Provisional; Region: PRK14902 767817007758 NusB family; Region: NusB; pfam01029 767817007759 putative RNA binding site [nucleotide binding]; other site 767817007760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817007761 S-adenosylmethionine binding site [chemical binding]; other site 767817007762 Protein of unknown function DUF116; Region: DUF116; pfam01976 767817007763 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 767817007764 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 767817007765 putative active site [active] 767817007766 substrate binding site [chemical binding]; other site 767817007767 putative cosubstrate binding site; other site 767817007768 catalytic site [active] 767817007769 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 767817007770 substrate binding site [chemical binding]; other site 767817007771 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 767817007772 active site 767817007773 catalytic residues [active] 767817007774 metal binding site [ion binding]; metal-binding site 767817007775 primosome assembly protein PriA; Validated; Region: PRK05580 767817007776 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817007777 ATP binding site [chemical binding]; other site 767817007778 putative Mg++ binding site [ion binding]; other site 767817007779 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817007780 ATP-binding site [chemical binding]; other site 767817007781 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 767817007782 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767817007783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817007784 Walker A/P-loop; other site 767817007785 ATP binding site [chemical binding]; other site 767817007786 Q-loop/lid; other site 767817007787 ABC transporter signature motif; other site 767817007788 Walker B; other site 767817007789 D-loop; other site 767817007790 H-loop/switch region; other site 767817007791 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 767817007792 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39D; cd02420 767817007793 putative active site [active] 767817007794 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767817007795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817007796 Walker A/P-loop; other site 767817007797 ATP binding site [chemical binding]; other site 767817007798 Q-loop/lid; other site 767817007799 ABC transporter signature motif; other site 767817007800 Walker B; other site 767817007801 D-loop; other site 767817007802 H-loop/switch region; other site 767817007803 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 767817007804 carboxyltransferase (CT) interaction site; other site 767817007805 biotinylation site [posttranslational modification]; other site 767817007806 HlyD family secretion protein; Region: HlyD_3; pfam13437 767817007807 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767817007808 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767817007809 ligand binding site [chemical binding]; other site 767817007810 flexible hinge region; other site 767817007811 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767817007812 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767817007813 transmembrane helices; other site 767817007814 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 767817007815 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 767817007816 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817007817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817007818 active site 767817007819 phosphorylation site [posttranslational modification] 767817007820 intermolecular recognition site; other site 767817007821 dimerization interface [polypeptide binding]; other site 767817007822 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817007823 DNA binding site [nucleotide binding] 767817007824 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 767817007825 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 767817007826 CHASE2 domain; Region: CHASE2; pfam05226 767817007827 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 767817007828 cyclase homology domain; Region: CHD; cd07302 767817007829 nucleotidyl binding site; other site 767817007830 metal binding site [ion binding]; metal-binding site 767817007831 dimer interface [polypeptide binding]; other site 767817007832 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 767817007833 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 767817007834 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 767817007835 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817007836 FeS/SAM binding site; other site 767817007837 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 767817007838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817007839 Coenzyme A binding pocket [chemical binding]; other site 767817007840 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 767817007841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817007842 Coenzyme A binding pocket [chemical binding]; other site 767817007843 Peptidase family S41; Region: Peptidase_S41; pfam03572 767817007844 Active site serine [active] 767817007845 S-layer homology domain; Region: SLH; pfam00395 767817007846 S-layer homology domain; Region: SLH; pfam00395 767817007847 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 767817007848 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 767817007849 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 767817007850 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 767817007851 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 767817007852 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 767817007853 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 767817007854 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 767817007855 Catalytic domain of Protein Kinases; Region: PKc; cd00180 767817007856 active site 767817007857 ATP binding site [chemical binding]; other site 767817007858 substrate binding site [chemical binding]; other site 767817007859 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 767817007860 substrate binding site [chemical binding]; other site 767817007861 activation loop (A-loop); other site 767817007862 activation loop (A-loop); other site 767817007863 AAA ATPase domain; Region: AAA_16; pfam13191 767817007864 Predicted ATPase [General function prediction only]; Region: COG3899 767817007865 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 767817007866 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 767817007867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817007868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817007869 dimer interface [polypeptide binding]; other site 767817007870 phosphorylation site [posttranslational modification] 767817007871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817007872 ATP binding site [chemical binding]; other site 767817007873 Mg2+ binding site [ion binding]; other site 767817007874 G-X-G motif; other site 767817007875 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 767817007876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817007877 active site 767817007878 phosphorylation site [posttranslational modification] 767817007879 intermolecular recognition site; other site 767817007880 dimerization interface [polypeptide binding]; other site 767817007881 Hpt domain; Region: Hpt; pfam01627 767817007882 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 767817007883 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817007884 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 767817007885 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817007886 DNA binding residues [nucleotide binding] 767817007887 PspA/IM30 family; Region: PspA_IM30; pfam04012 767817007888 stage II sporulation protein P; Region: spore_II_P; TIGR02867 767817007889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 767817007890 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 767817007891 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 767817007892 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 767817007893 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767817007894 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767817007895 FtsX-like permease family; Region: FtsX; pfam02687 767817007896 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767817007897 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767817007898 Walker A/P-loop; other site 767817007899 ATP binding site [chemical binding]; other site 767817007900 Q-loop/lid; other site 767817007901 ABC transporter signature motif; other site 767817007902 Walker B; other site 767817007903 D-loop; other site 767817007904 H-loop/switch region; other site 767817007905 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 767817007906 HlyD family secretion protein; Region: HlyD_3; pfam13437 767817007907 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817007908 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 767817007909 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 767817007910 Predicted ATPase [General function prediction only]; Region: COG3910 767817007911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817007912 Walker A/P-loop; other site 767817007913 ATP binding site [chemical binding]; other site 767817007914 Q-loop/lid; other site 767817007915 ABC transporter signature motif; other site 767817007916 Walker B; other site 767817007917 D-loop; other site 767817007918 H-loop/switch region; other site 767817007919 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 767817007920 putative active site [active] 767817007921 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 767817007922 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 767817007923 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767817007924 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 767817007925 Fic/DOC family; Region: Fic; pfam02661 767817007926 Fic family protein [Function unknown]; Region: COG3177 767817007927 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 767817007928 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 767817007929 active site 767817007930 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 767817007931 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817007932 ATP binding site [chemical binding]; other site 767817007933 putative Mg++ binding site [ion binding]; other site 767817007934 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817007935 nucleotide binding region [chemical binding]; other site 767817007936 ATP-binding site [chemical binding]; other site 767817007937 DEAD/H associated; Region: DEAD_assoc; pfam08494 767817007938 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767817007939 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 767817007940 homotrimer interaction site [polypeptide binding]; other site 767817007941 putative active site [active] 767817007942 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 767817007943 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 767817007944 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 767817007945 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 767817007946 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767817007947 4Fe-4S binding domain; Region: Fer4; pfam00037 767817007948 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 767817007949 catalytic loop [active] 767817007950 iron binding site [ion binding]; other site 767817007951 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 767817007952 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 767817007953 active site 767817007954 FMN binding site [chemical binding]; other site 767817007955 substrate binding site [chemical binding]; other site 767817007956 3Fe-4S cluster binding site [ion binding]; other site 767817007957 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 767817007958 domain_subunit interface; other site 767817007959 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 767817007960 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 767817007961 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 767817007962 active site 767817007963 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 767817007964 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 767817007965 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 767817007966 FOG: WD40 repeat [General function prediction only]; Region: COG2319 767817007967 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 767817007968 structural tetrad; other site 767817007969 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 767817007970 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 767817007971 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 767817007972 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 767817007973 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 767817007974 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767817007975 catalytic residue [active] 767817007976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817007977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817007978 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 767817007979 GAF domain; Region: GAF; pfam01590 767817007980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817007981 Walker A motif; other site 767817007982 ATP binding site [chemical binding]; other site 767817007983 Walker B motif; other site 767817007984 arginine finger; other site 767817007985 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817007986 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 767817007987 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 767817007988 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 767817007989 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 767817007990 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 767817007991 active site 767817007992 multimer interface [polypeptide binding]; other site 767817007993 antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819 767817007994 toxin interface [polypeptide binding]; other site 767817007995 Zn binding site [ion binding]; other site 767817007996 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 767817007997 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 767817007998 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 767817007999 DNA binding residues [nucleotide binding] 767817008000 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 767817008001 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 767817008002 active site 767817008003 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767817008004 active site 767817008005 catalytic site [active] 767817008006 substrate binding site [chemical binding]; other site 767817008007 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 767817008008 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 767817008009 active site 767817008010 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 767817008011 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 767817008012 inhibitor-cofactor binding pocket; inhibition site 767817008013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817008014 catalytic residue [active] 767817008015 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 767817008016 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 767817008017 hexamer interface [polypeptide binding]; other site 767817008018 ligand binding site [chemical binding]; other site 767817008019 putative active site [active] 767817008020 NAD(P) binding site [chemical binding]; other site 767817008021 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 767817008022 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 767817008023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817008024 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767817008025 Cysteine-rich domain; Region: CCG; pfam02754 767817008026 Cysteine-rich domain; Region: CCG; pfam02754 767817008027 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817008028 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 767817008029 catalytic loop [active] 767817008030 iron binding site [ion binding]; other site 767817008031 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 767817008032 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 767817008033 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 767817008034 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 767817008035 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 767817008036 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 767817008037 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 767817008038 catalytic Zn binding site [ion binding]; other site 767817008039 NAD binding site [chemical binding]; other site 767817008040 structural Zn binding site [ion binding]; other site 767817008041 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 767817008042 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 767817008043 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767817008044 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 767817008045 putative DNA binding site [nucleotide binding]; other site 767817008046 putative Zn2+ binding site [ion binding]; other site 767817008047 AsnC family; Region: AsnC_trans_reg; pfam01037 767817008048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817008049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817008050 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 767817008051 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767817008052 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767817008053 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 767817008054 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 767817008055 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 767817008056 CPxP motif; other site 767817008057 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817008058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817008059 active site 767817008060 phosphorylation site [posttranslational modification] 767817008061 intermolecular recognition site; other site 767817008062 dimerization interface [polypeptide binding]; other site 767817008063 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817008064 DNA binding site [nucleotide binding] 767817008065 Cache domain; Region: Cache_1; pfam02743 767817008066 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817008067 dimerization interface [polypeptide binding]; other site 767817008068 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817008069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817008070 dimer interface [polypeptide binding]; other site 767817008071 phosphorylation site [posttranslational modification] 767817008072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817008073 ATP binding site [chemical binding]; other site 767817008074 Mg2+ binding site [ion binding]; other site 767817008075 G-X-G motif; other site 767817008076 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 767817008077 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 767817008078 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 767817008079 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 767817008080 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 767817008081 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 767817008082 ResB-like family; Region: ResB; pfam05140 767817008083 YmaF family; Region: YmaF; pfam12788 767817008084 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 767817008085 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 767817008086 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817008087 acyl-activating enzyme (AAE) consensus motif; other site 767817008088 active site 767817008089 AMP binding site [chemical binding]; other site 767817008090 CoA binding site [chemical binding]; other site 767817008091 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 767817008092 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 767817008093 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 767817008094 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 767817008095 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 767817008096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817008097 S-adenosylmethionine binding site [chemical binding]; other site 767817008098 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767817008099 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767817008100 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 767817008101 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 767817008102 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 767817008103 PYR/PP interface [polypeptide binding]; other site 767817008104 dimer interface [polypeptide binding]; other site 767817008105 tetramer interface [polypeptide binding]; other site 767817008106 TPP binding site [chemical binding]; other site 767817008107 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 767817008108 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 767817008109 TPP-binding site [chemical binding]; other site 767817008110 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 767817008111 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 767817008112 TPP-binding site; other site 767817008113 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 767817008114 PYR/PP interface [polypeptide binding]; other site 767817008115 dimer interface [polypeptide binding]; other site 767817008116 TPP binding site [chemical binding]; other site 767817008117 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767817008118 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 767817008119 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 767817008120 catalytic residue [active] 767817008121 putative FPP diphosphate binding site; other site 767817008122 putative FPP binding hydrophobic cleft; other site 767817008123 dimer interface [polypeptide binding]; other site 767817008124 putative IPP diphosphate binding site; other site 767817008125 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 767817008126 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 767817008127 putative dimer interface [polypeptide binding]; other site 767817008128 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 767817008129 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 767817008130 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 767817008131 putative DNA binding site [nucleotide binding]; other site 767817008132 putative Zn2+ binding site [ion binding]; other site 767817008133 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 767817008134 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817008135 FeS/SAM binding site; other site 767817008136 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 767817008137 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 767817008138 ResB-like family; Region: ResB; pfam05140 767817008139 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 767817008140 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 767817008141 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 767817008142 Cytochrome c552; Region: Cytochrom_C552; pfam02335 767817008143 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 767817008144 HAMP domain; Region: HAMP; pfam00672 767817008145 dimerization interface [polypeptide binding]; other site 767817008146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817008147 dimer interface [polypeptide binding]; other site 767817008148 phosphorylation site [posttranslational modification] 767817008149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817008150 ATP binding site [chemical binding]; other site 767817008151 Mg2+ binding site [ion binding]; other site 767817008152 G-X-G motif; other site 767817008153 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817008154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817008155 active site 767817008156 phosphorylation site [posttranslational modification] 767817008157 intermolecular recognition site; other site 767817008158 dimerization interface [polypeptide binding]; other site 767817008159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817008160 DNA binding site [nucleotide binding] 767817008161 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 767817008162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767817008163 motif II; other site 767817008164 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 767817008165 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 767817008166 active site 767817008167 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 767817008168 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 767817008169 dimer interface [polypeptide binding]; other site 767817008170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817008171 catalytic residue [active] 767817008172 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767817008173 MarR family; Region: MarR; pfam01047 767817008174 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 767817008175 Flavoprotein; Region: Flavoprotein; pfam02441 767817008176 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 767817008177 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 767817008178 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 767817008179 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 767817008180 catalytic site [active] 767817008181 G-X2-G-X-G-K; other site 767817008182 hypothetical protein; Provisional; Region: PRK04323 767817008183 hypothetical protein; Provisional; Region: PRK11820 767817008184 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 767817008185 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 767817008186 aspartate aminotransferase; Provisional; Region: PRK05764 767817008187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767817008188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817008189 homodimer interface [polypeptide binding]; other site 767817008190 catalytic residue [active] 767817008191 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 767817008192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767817008193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817008194 homodimer interface [polypeptide binding]; other site 767817008195 catalytic residue [active] 767817008196 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 767817008197 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 767817008198 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 767817008199 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 767817008200 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767817008201 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767817008202 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 767817008203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767817008204 motif II; other site 767817008205 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 767817008206 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 767817008207 Domain of unknown function (DUF814); Region: DUF814; pfam05670 767817008208 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 767817008209 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 767817008210 Putative amidase domain; Region: Amidase_6; pfam12671 767817008211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817008212 ATP binding site [chemical binding]; other site 767817008213 Mg2+ binding site [ion binding]; other site 767817008214 G-X-G motif; other site 767817008215 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 767817008216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817008217 active site 767817008218 phosphorylation site [posttranslational modification] 767817008219 intermolecular recognition site; other site 767817008220 dimerization interface [polypeptide binding]; other site 767817008221 LytTr DNA-binding domain; Region: LytTR; pfam04397 767817008222 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 767817008223 Accessory gene regulator B; Region: AgrB; pfam04647 767817008224 Transposase domain (DUF772); Region: DUF772; pfam05598 767817008225 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767817008226 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767817008227 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 767817008228 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 767817008229 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 767817008230 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817008231 active site 767817008232 Int/Topo IB signature motif; other site 767817008233 DNA binding site [nucleotide binding] 767817008234 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817008235 active site 767817008236 DNA binding site [nucleotide binding] 767817008237 Int/Topo IB signature motif; other site 767817008238 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 767817008239 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817008240 active site 767817008241 DNA binding site [nucleotide binding] 767817008242 Int/Topo IB signature motif; other site 767817008243 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 767817008244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817008245 Walker A motif; other site 767817008246 ATP binding site [chemical binding]; other site 767817008247 Walker B motif; other site 767817008248 arginine finger; other site 767817008249 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 767817008250 Walker A/P-loop; other site 767817008251 ATP binding site [chemical binding]; other site 767817008252 Q-loop/lid; other site 767817008253 ABC transporter signature motif; other site 767817008254 Walker B; other site 767817008255 D-loop; other site 767817008256 H-loop/switch region; other site 767817008257 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 767817008258 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 767817008259 HlyD family secretion protein; Region: HlyD_3; pfam13437 767817008260 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767817008261 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767817008262 FtsX-like permease family; Region: FtsX; pfam02687 767817008263 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767817008264 FtsX-like permease family; Region: FtsX; pfam02687 767817008265 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767817008266 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767817008267 Walker A/P-loop; other site 767817008268 ATP binding site [chemical binding]; other site 767817008269 Q-loop/lid; other site 767817008270 ABC transporter signature motif; other site 767817008271 Walker B; other site 767817008272 D-loop; other site 767817008273 H-loop/switch region; other site 767817008274 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 767817008275 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 767817008276 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 767817008277 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 767817008278 oligomer interface [polypeptide binding]; other site 767817008279 active site 767817008280 metal binding site [ion binding]; metal-binding site 767817008281 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 767817008282 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 767817008283 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 767817008284 putative active site [active] 767817008285 metal binding site [ion binding]; metal-binding site 767817008286 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 767817008287 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 767817008288 PAS domain; Region: PAS_9; pfam13426 767817008289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817008290 dimer interface [polypeptide binding]; other site 767817008291 phosphorylation site [posttranslational modification] 767817008292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817008293 ATP binding site [chemical binding]; other site 767817008294 Mg2+ binding site [ion binding]; other site 767817008295 G-X-G motif; other site 767817008296 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 767817008297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817008298 active site 767817008299 phosphorylation site [posttranslational modification] 767817008300 intermolecular recognition site; other site 767817008301 dimerization interface [polypeptide binding]; other site 767817008302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817008303 Walker A motif; other site 767817008304 ATP binding site [chemical binding]; other site 767817008305 Walker B motif; other site 767817008306 arginine finger; other site 767817008307 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817008308 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 767817008309 putative alcohol dehydrogenase; Provisional; Region: PRK09860 767817008310 dimer interface [polypeptide binding]; other site 767817008311 active site 767817008312 metal binding site [ion binding]; metal-binding site 767817008313 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 767817008314 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 767817008315 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 767817008316 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 767817008317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817008318 FeS/SAM binding site; other site 767817008319 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 767817008320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817008321 PAS domain; Region: PAS_9; pfam13426 767817008322 putative active site [active] 767817008323 heme pocket [chemical binding]; other site 767817008324 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 767817008325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817008326 Walker A motif; other site 767817008327 ATP binding site [chemical binding]; other site 767817008328 Walker B motif; other site 767817008329 arginine finger; other site 767817008330 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817008331 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 767817008332 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 767817008333 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 767817008334 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 767817008335 TPP-binding site [chemical binding]; other site 767817008336 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 767817008337 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 767817008338 dimer interface [polypeptide binding]; other site 767817008339 PYR/PP interface [polypeptide binding]; other site 767817008340 TPP binding site [chemical binding]; other site 767817008341 substrate binding site [chemical binding]; other site 767817008342 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767817008343 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817008344 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 767817008345 Cupin domain; Region: Cupin_2; pfam07883 767817008346 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 767817008347 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 767817008348 active site 767817008349 dimer interface [polypeptide binding]; other site 767817008350 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 767817008351 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 767817008352 heterodimer interface [polypeptide binding]; other site 767817008353 active site 767817008354 FMN binding site [chemical binding]; other site 767817008355 homodimer interface [polypeptide binding]; other site 767817008356 substrate binding site [chemical binding]; other site 767817008357 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 767817008358 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 767817008359 FAD binding pocket [chemical binding]; other site 767817008360 FAD binding motif [chemical binding]; other site 767817008361 phosphate binding motif [ion binding]; other site 767817008362 beta-alpha-beta structure motif; other site 767817008363 NAD binding pocket [chemical binding]; other site 767817008364 Iron coordination center [ion binding]; other site 767817008365 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 767817008366 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767817008367 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 767817008368 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 767817008369 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767817008370 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767817008371 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 767817008372 IMP binding site; other site 767817008373 dimer interface [polypeptide binding]; other site 767817008374 interdomain contacts; other site 767817008375 partial ornithine binding site; other site 767817008376 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 767817008377 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 767817008378 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 767817008379 catalytic site [active] 767817008380 subunit interface [polypeptide binding]; other site 767817008381 dihydroorotase; Validated; Region: pyrC; PRK09357 767817008382 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767817008383 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 767817008384 active site 767817008385 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 767817008386 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 767817008387 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 767817008388 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 767817008389 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767817008390 active site 767817008391 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 767817008392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767817008393 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767817008394 putative substrate translocation pore; other site 767817008395 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 767817008396 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 767817008397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817008398 S-adenosylmethionine binding site [chemical binding]; other site 767817008399 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 767817008400 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 767817008401 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 767817008402 active site 767817008403 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 767817008404 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767817008405 Cysteine-rich domain; Region: CCG; pfam02754 767817008406 Putative Fe-S cluster; Region: FeS; cl17515 767817008407 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817008408 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817008409 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 767817008410 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 767817008411 putative active site [active] 767817008412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 767817008413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767817008414 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 767817008415 4Fe-4S binding domain; Region: Fer4; cl02805 767817008416 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 767817008417 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767817008418 ACS interaction site; other site 767817008419 CODH interaction site; other site 767817008420 metal cluster binding site [ion binding]; other site 767817008421 Rrf2 family protein; Region: rrf2_super; TIGR00738 767817008422 Transcriptional regulator; Region: Rrf2; pfam02082 767817008423 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 767817008424 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767817008425 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817008426 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817008427 DNA binding residues [nucleotide binding] 767817008428 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 767817008429 active site 767817008430 NTP binding site [chemical binding]; other site 767817008431 metal binding triad [ion binding]; metal-binding site 767817008432 antibiotic binding site [chemical binding]; other site 767817008433 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 767817008434 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 767817008435 Putative zinc-finger; Region: zf-HC2; pfam13490 767817008436 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 767817008437 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817008438 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817008439 DNA binding residues [nucleotide binding] 767817008440 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 767817008441 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 767817008442 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 767817008443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817008444 ATP binding site [chemical binding]; other site 767817008445 putative Mg++ binding site [ion binding]; other site 767817008446 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 767817008447 A new structural DNA glycosylase; Region: AlkD_like; cd06561 767817008448 active site 767817008449 biotin synthase; Region: bioB; TIGR00433 767817008450 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817008451 FeS/SAM binding site; other site 767817008452 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 767817008453 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 767817008454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817008455 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817008456 dimerization interface [polypeptide binding]; other site 767817008457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817008458 dimer interface [polypeptide binding]; other site 767817008459 phosphorylation site [posttranslational modification] 767817008460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817008461 ATP binding site [chemical binding]; other site 767817008462 Mg2+ binding site [ion binding]; other site 767817008463 G-X-G motif; other site 767817008464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817008465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817008466 active site 767817008467 phosphorylation site [posttranslational modification] 767817008468 intermolecular recognition site; other site 767817008469 dimerization interface [polypeptide binding]; other site 767817008470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817008471 DNA binding site [nucleotide binding] 767817008472 Family description; Region: VCBS; pfam13517 767817008473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767817008474 binding surface 767817008475 TPR motif; other site 767817008476 Tetratricopeptide repeat; Region: TPR_12; pfam13424 767817008477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 767817008478 Sensory domain found in PocR; Region: PocR; pfam10114 767817008479 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 767817008480 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767817008481 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767817008482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767817008483 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 767817008484 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_3; cd09321 767817008485 gating phenylalanine in ion channel; other site 767817008486 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 767817008487 ATP binding site [chemical binding]; other site 767817008488 VanW like protein; Region: VanW; pfam04294 767817008489 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 767817008490 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 767817008491 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767817008492 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 767817008493 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767817008494 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817008495 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817008496 DNA binding residues [nucleotide binding] 767817008497 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 767817008498 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817008499 ATP binding site [chemical binding]; other site 767817008500 putative Mg++ binding site [ion binding]; other site 767817008501 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817008502 nucleotide binding region [chemical binding]; other site 767817008503 ATP-binding site [chemical binding]; other site 767817008504 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 767817008505 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 767817008506 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817008507 NADH dehydrogenase subunit G; Validated; Region: PRK09129 767817008508 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 767817008509 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 767817008510 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 767817008511 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817008512 YvrJ protein family; Region: YvrJ; pfam12841 767817008513 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817008514 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817008515 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817008516 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767817008517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817008518 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817008519 DNA binding residues [nucleotide binding] 767817008520 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 767817008521 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 767817008522 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 767817008523 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 767817008524 putative active site [active] 767817008525 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 767817008526 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 767817008527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817008528 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817008529 DNA binding residues [nucleotide binding] 767817008530 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 767817008531 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817008532 active site 767817008533 Int/Topo IB signature motif; other site 767817008534 DNA binding site [nucleotide binding] 767817008535 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 767817008536 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817008537 active site 767817008538 DNA binding site [nucleotide binding] 767817008539 Int/Topo IB signature motif; other site 767817008540 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 767817008541 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817008542 active site 767817008543 DNA binding site [nucleotide binding] 767817008544 Int/Topo IB signature motif; other site 767817008545 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817008546 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 767817008547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767817008548 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 767817008549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767817008550 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 767817008551 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 767817008552 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 767817008553 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817008554 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 767817008555 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 767817008556 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 767817008557 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 767817008558 active site 767817008559 metal binding site [ion binding]; metal-binding site 767817008560 Penicillinase repressor; Region: Pencillinase_R; pfam03965 767817008561 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817008562 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817008563 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817008564 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 767817008565 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 767817008566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817008567 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817008568 DNA binding residues [nucleotide binding] 767817008569 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817008570 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817008571 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 767817008572 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 767817008573 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 767817008574 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 767817008575 putative dimer interface [polypeptide binding]; other site 767817008576 [2Fe-2S] cluster binding site [ion binding]; other site 767817008577 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 767817008578 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 767817008579 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 767817008580 Putative Fe-S cluster; Region: FeS; cl17515 767817008581 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817008582 PAS domain; Region: PAS_9; pfam13426 767817008583 putative active site [active] 767817008584 heme pocket [chemical binding]; other site 767817008585 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817008586 catalytic loop [active] 767817008587 iron binding site [ion binding]; other site 767817008588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 767817008589 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 767817008590 4Fe-4S binding domain; Region: Fer4; pfam00037 767817008591 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 767817008592 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 767817008593 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 767817008594 dimer interface [polypeptide binding]; other site 767817008595 [2Fe-2S] cluster binding site [ion binding]; other site 767817008596 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 767817008597 dimer interface [polypeptide binding]; other site 767817008598 [2Fe-2S] cluster binding site [ion binding]; other site 767817008599 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 767817008600 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 767817008601 SLBB domain; Region: SLBB; pfam10531 767817008602 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 767817008603 4Fe-4S binding domain; Region: Fer4; pfam00037 767817008604 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 767817008605 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 767817008606 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 767817008607 putative dimer interface [polypeptide binding]; other site 767817008608 [2Fe-2S] cluster binding site [ion binding]; other site 767817008609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817008610 non-specific DNA binding site [nucleotide binding]; other site 767817008611 salt bridge; other site 767817008612 sequence-specific DNA binding site [nucleotide binding]; other site 767817008613 Cupin domain; Region: Cupin_2; cl17218 767817008614 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 767817008615 homotrimer interaction site [polypeptide binding]; other site 767817008616 putative active site [active] 767817008617 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 767817008618 CoA binding domain; Region: CoA_binding_2; pfam13380 767817008619 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 767817008620 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 767817008621 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 767817008622 Transcriptional regulator [Transcription]; Region: IclR; COG1414 767817008623 Bacterial transcriptional regulator; Region: IclR; pfam01614 767817008624 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 767817008625 serpin-like protein; Provisional; Region: PHA02660 767817008626 reactive center loop; other site 767817008627 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767817008628 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767817008629 Walker A/P-loop; other site 767817008630 ATP binding site [chemical binding]; other site 767817008631 Q-loop/lid; other site 767817008632 ABC transporter signature motif; other site 767817008633 Walker B; other site 767817008634 D-loop; other site 767817008635 H-loop/switch region; other site 767817008636 Predicted transcriptional regulators [Transcription]; Region: COG1725 767817008637 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767817008638 DNA-binding site [nucleotide binding]; DNA binding site 767817008639 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 767817008640 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767817008641 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767817008642 Walker A/P-loop; other site 767817008643 ATP binding site [chemical binding]; other site 767817008644 Q-loop/lid; other site 767817008645 ABC transporter signature motif; other site 767817008646 Walker B; other site 767817008647 D-loop; other site 767817008648 H-loop/switch region; other site 767817008649 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817008650 serpin-like protein; Provisional; Region: PHA02660 767817008651 SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049 767817008652 reactive center loop; other site 767817008653 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 767817008654 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767817008655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817008656 homodimer interface [polypeptide binding]; other site 767817008657 catalytic residue [active] 767817008658 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 767817008659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767817008660 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767817008661 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 767817008662 hypothetical protein; Provisional; Region: PRK06194 767817008663 classical (c) SDRs; Region: SDR_c; cd05233 767817008664 NAD(P) binding site [chemical binding]; other site 767817008665 active site 767817008666 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817008667 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817008668 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 767817008669 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 767817008670 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 767817008671 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817008672 Coenzyme A binding pocket [chemical binding]; other site 767817008673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817008674 Coenzyme A binding pocket [chemical binding]; other site 767817008675 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 767817008676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817008677 Coenzyme A binding pocket [chemical binding]; other site 767817008678 Predicted transcriptional regulators [Transcription]; Region: COG1733 767817008679 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 767817008680 CGGC domain; Region: CGGC; cl02356 767817008681 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 767817008682 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 767817008683 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767817008684 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767817008685 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 767817008686 CoenzymeA binding site [chemical binding]; other site 767817008687 subunit interaction site [polypeptide binding]; other site 767817008688 PHB binding site; other site 767817008689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817008690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817008691 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 767817008692 FMN binding site [chemical binding]; other site 767817008693 dimer interface [polypeptide binding]; other site 767817008694 Transposase [DNA replication, recombination, and repair]; Region: COG5421 767817008695 Nitroreductase family; Region: Nitroreductase; pfam00881 767817008696 FMN binding site [chemical binding]; other site 767817008697 Predicted transcriptional regulators [Transcription]; Region: COG1733 767817008698 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 767817008699 Protein of unknown function DUF86; Region: DUF86; pfam01934 767817008700 Protein of unknown function DUF45; Region: DUF45; pfam01863 767817008701 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 767817008702 putative active site [active] 767817008703 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 767817008704 substrate binding site [chemical binding]; other site 767817008705 multimerization interface [polypeptide binding]; other site 767817008706 ATP binding site [chemical binding]; other site 767817008707 FOG: CBS domain [General function prediction only]; Region: COG0517 767817008708 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 767817008709 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 767817008710 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 767817008711 metal binding site [ion binding]; metal-binding site 767817008712 active site 767817008713 I-site; other site 767817008714 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817008715 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 767817008716 Zn2+ binding site [ion binding]; other site 767817008717 Mg2+ binding site [ion binding]; other site 767817008718 GEMM cis-regulatory element; Desgi_3251; IMG reference gene:2508514216 767817008719 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767817008720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817008721 non-specific DNA binding site [nucleotide binding]; other site 767817008722 salt bridge; other site 767817008723 sequence-specific DNA binding site [nucleotide binding]; other site 767817008724 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 767817008725 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 767817008726 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 767817008727 catalytic residues [active] 767817008728 Carbonic anhydrase; Region: Pro_CA; smart00947 767817008729 active site clefts [active] 767817008730 zinc binding site [ion binding]; other site 767817008731 Tic20-like protein; Region: Tic20; pfam09685 767817008732 Protein of unknown function DUF45; Region: DUF45; pfam01863 767817008733 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 767817008734 Protein of unknown function (DUF441); Region: DUF441; pfam04284 767817008735 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767817008736 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767817008737 RNA binding surface [nucleotide binding]; other site 767817008738 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767817008739 active site 767817008740 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 767817008741 Predicted integral membrane protein [Function unknown]; Region: COG5652 767817008742 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817008743 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 767817008744 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 767817008745 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 767817008746 inhibitor-cofactor binding pocket; inhibition site 767817008747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817008748 catalytic residue [active] 767817008749 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 767817008750 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767817008751 active site 767817008752 metal binding site [ion binding]; metal-binding site 767817008753 aspartate aminotransferase; Provisional; Region: PRK06836 767817008754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767817008755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817008756 homodimer interface [polypeptide binding]; other site 767817008757 catalytic residue [active] 767817008758 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767817008759 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 767817008760 active site 767817008761 metal binding site [ion binding]; metal-binding site 767817008762 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 767817008763 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 767817008764 nudix motif; other site 767817008765 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 767817008766 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 767817008767 ABC-ATPase subunit interface; other site 767817008768 dimer interface [polypeptide binding]; other site 767817008769 putative PBP binding regions; other site 767817008770 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767817008771 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 767817008772 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 767817008773 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 767817008774 metal binding site [ion binding]; metal-binding site 767817008775 ferric uptake regulator; Provisional; Region: fur; PRK09462 767817008776 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 767817008777 metal binding site 2 [ion binding]; metal-binding site 767817008778 putative DNA binding helix; other site 767817008779 metal binding site 1 [ion binding]; metal-binding site 767817008780 dimer interface [polypeptide binding]; other site 767817008781 structural Zn2+ binding site [ion binding]; other site 767817008782 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767817008783 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 767817008784 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 767817008785 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 767817008786 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 767817008787 active site 767817008788 (T/H)XGH motif; other site 767817008789 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 767817008790 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 767817008791 putative catalytic cysteine [active] 767817008792 gamma-glutamyl kinase; Provisional; Region: PRK05429 767817008793 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 767817008794 nucleotide binding site [chemical binding]; other site 767817008795 homotetrameric interface [polypeptide binding]; other site 767817008796 putative phosphate binding site [ion binding]; other site 767817008797 putative allosteric binding site; other site 767817008798 PUA domain; Region: PUA; pfam01472 767817008799 GTPase CgtA; Reviewed; Region: obgE; PRK12297 767817008800 GTP1/OBG; Region: GTP1_OBG; pfam01018 767817008801 Obg GTPase; Region: Obg; cd01898 767817008802 G1 box; other site 767817008803 GTP/Mg2+ binding site [chemical binding]; other site 767817008804 Switch I region; other site 767817008805 G2 box; other site 767817008806 G3 box; other site 767817008807 Switch II region; other site 767817008808 G4 box; other site 767817008809 G5 box; other site 767817008810 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 767817008811 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 767817008812 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 767817008813 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 767817008814 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 767817008815 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 767817008816 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 767817008817 homodimer interface [polypeptide binding]; other site 767817008818 oligonucleotide binding site [chemical binding]; other site 767817008819 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 767817008820 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 767817008821 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 767817008822 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 767817008823 B12 binding site [chemical binding]; other site 767817008824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817008825 FeS/SAM binding site; other site 767817008826 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 767817008827 Peptidase family M50; Region: Peptidase_M50; pfam02163 767817008828 active site 767817008829 putative substrate binding region [chemical binding]; other site 767817008830 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 767817008831 Peptidase family M23; Region: Peptidase_M23; pfam01551 767817008832 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 767817008833 Septum formation topological specificity factor MinE; Region: MinE; cl00538 767817008834 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 767817008835 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 767817008836 Switch I; other site 767817008837 Switch II; other site 767817008838 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 767817008839 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767817008840 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 767817008841 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767817008842 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767817008843 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 767817008844 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 767817008845 rod shape-determining protein MreC; Provisional; Region: PRK13922 767817008846 rod shape-determining protein MreC; Region: MreC; pfam04085 767817008847 rod shape-determining protein MreB; Provisional; Region: PRK13927 767817008848 MreB and similar proteins; Region: MreB_like; cd10225 767817008849 nucleotide binding site [chemical binding]; other site 767817008850 Mg binding site [ion binding]; other site 767817008851 putative protofilament interaction site [polypeptide binding]; other site 767817008852 RodZ interaction site [polypeptide binding]; other site 767817008853 hypothetical protein; Reviewed; Region: PRK00024 767817008854 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 767817008855 MPN+ (JAMM) motif; other site 767817008856 Zinc-binding site [ion binding]; other site 767817008857 Maf-like protein; Region: Maf; pfam02545 767817008858 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 767817008859 active site 767817008860 dimer interface [polypeptide binding]; other site 767817008861 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 767817008862 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 767817008863 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767817008864 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767817008865 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 767817008866 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 767817008867 dimer interface [polypeptide binding]; other site 767817008868 putative CheW interface [polypeptide binding]; other site 767817008869 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 767817008870 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 767817008871 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 767817008872 G1 box; other site 767817008873 GTP/Mg2+ binding site [chemical binding]; other site 767817008874 Switch I region; other site 767817008875 G2 box; other site 767817008876 G3 box; other site 767817008877 Switch II region; other site 767817008878 G4 box; other site 767817008879 G5 box; other site 767817008880 Nucleoside recognition; Region: Gate; pfam07670 767817008881 Nucleoside recognition; Region: Gate; pfam07670 767817008882 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 767817008883 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 767817008884 HIGH motif; other site 767817008885 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 767817008886 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 767817008887 active site 767817008888 KMSKS motif; other site 767817008889 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 767817008890 tRNA binding surface [nucleotide binding]; other site 767817008891 anticodon binding site; other site 767817008892 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 767817008893 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 767817008894 NMT1/THI5 like; Region: NMT1; pfam09084 767817008895 Small acid-soluble spore protein H family; Region: SspH; pfam08141 767817008896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767817008897 Probable transposase; Region: OrfB_IS605; pfam01385 767817008898 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767817008899 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 767817008900 G1 box; other site 767817008901 GTP/Mg2+ binding site [chemical binding]; other site 767817008902 Switch I region; other site 767817008903 G2 box; other site 767817008904 G3 box; other site 767817008905 Switch II region; other site 767817008906 G4 box; other site 767817008907 G5 box; other site 767817008908 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 767817008909 Found in ATP-dependent protease La (LON); Region: LON; smart00464 767817008910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817008911 Walker A motif; other site 767817008912 ATP binding site [chemical binding]; other site 767817008913 Walker B motif; other site 767817008914 arginine finger; other site 767817008915 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 767817008916 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 767817008917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817008918 Walker A motif; other site 767817008919 ATP binding site [chemical binding]; other site 767817008920 Walker B motif; other site 767817008921 arginine finger; other site 767817008922 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 767817008923 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 767817008924 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 767817008925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817008926 Walker A motif; other site 767817008927 ATP binding site [chemical binding]; other site 767817008928 Walker B motif; other site 767817008929 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 767817008930 Clp protease; Region: CLP_protease; pfam00574 767817008931 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 767817008932 oligomer interface [polypeptide binding]; other site 767817008933 active site residues [active] 767817008934 trigger factor; Provisional; Region: tig; PRK01490 767817008935 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 767817008936 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 767817008937 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 767817008938 carboxyltransferase (CT) interaction site; other site 767817008939 biotinylation site [posttranslational modification]; other site 767817008940 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 767817008941 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 767817008942 dimer interface [polypeptide binding]; other site 767817008943 active site 767817008944 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767817008945 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 767817008946 FAD binding site [chemical binding]; other site 767817008947 homotetramer interface [polypeptide binding]; other site 767817008948 substrate binding pocket [chemical binding]; other site 767817008949 catalytic base [active] 767817008950 EamA-like transporter family; Region: EamA; pfam00892 767817008951 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 767817008952 EamA-like transporter family; Region: EamA; pfam00892 767817008953 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 767817008954 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 767817008955 CoenzymeA binding site [chemical binding]; other site 767817008956 subunit interaction site [polypeptide binding]; other site 767817008957 PHB binding site; other site 767817008958 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 767817008959 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 767817008960 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 767817008961 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 767817008962 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767817008963 dimerization interface [polypeptide binding]; other site 767817008964 putative DNA binding site [nucleotide binding]; other site 767817008965 putative Zn2+ binding site [ion binding]; other site 767817008966 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 767817008967 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 767817008968 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 767817008969 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 767817008970 Dynamin family; Region: Dynamin_N; pfam00350 767817008971 G1 box; other site 767817008972 GTP/Mg2+ binding site [chemical binding]; other site 767817008973 G2 box; other site 767817008974 Switch I region; other site 767817008975 G3 box; other site 767817008976 Switch II region; other site 767817008977 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 767817008978 G1 box; other site 767817008979 GTP/Mg2+ binding site [chemical binding]; other site 767817008980 G2 box; other site 767817008981 Switch I region; other site 767817008982 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 767817008983 G3 box; other site 767817008984 Switch II region; other site 767817008985 GTP/Mg2+ binding site [chemical binding]; other site 767817008986 G4 box; other site 767817008987 G5 box; other site 767817008988 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 767817008989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817008990 Walker A motif; other site 767817008991 ATP binding site [chemical binding]; other site 767817008992 Walker B motif; other site 767817008993 arginine finger; other site 767817008994 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 767817008995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767817008996 motif II; other site 767817008997 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 767817008998 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 767817008999 DRTGG domain; Region: DRTGG; pfam07085 767817009000 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 767817009001 CoA binding domain; Region: CoA_binding_2; pfam13380 767817009002 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 767817009003 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 767817009004 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 767817009005 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 767817009006 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 767817009007 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 767817009008 PspC domain; Region: PspC; pfam04024 767817009009 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 767817009010 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 767817009011 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 767817009012 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 767817009013 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 767817009014 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 767817009015 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 767817009016 HIGH motif; other site 767817009017 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 767817009018 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 767817009019 active site 767817009020 KMSKS motif; other site 767817009021 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 767817009022 tRNA binding surface [nucleotide binding]; other site 767817009023 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 767817009024 AMP-binding domain protein; Validated; Region: PRK08315 767817009025 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817009026 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 767817009027 acyl-activating enzyme (AAE) consensus motif; other site 767817009028 putative AMP binding site [chemical binding]; other site 767817009029 putative active site [active] 767817009030 putative CoA binding site [chemical binding]; other site 767817009031 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 767817009032 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817009033 Zn2+ binding site [ion binding]; other site 767817009034 Mg2+ binding site [ion binding]; other site 767817009035 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 767817009036 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 767817009037 Spore germination protein; Region: Spore_permease; cl17796 767817009038 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 767817009039 Coat F domain; Region: Coat_F; pfam07875 767817009040 methionine aminopeptidase; Provisional; Region: PRK12318 767817009041 SEC-C motif; Region: SEC-C; pfam02810 767817009042 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 767817009043 active site 767817009044 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767817009045 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767817009046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817009047 S-adenosylmethionine binding site [chemical binding]; other site 767817009048 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817009049 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817009050 dimerization interface [polypeptide binding]; other site 767817009051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817009052 dimer interface [polypeptide binding]; other site 767817009053 phosphorylation site [posttranslational modification] 767817009054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817009055 ATP binding site [chemical binding]; other site 767817009056 Mg2+ binding site [ion binding]; other site 767817009057 G-X-G motif; other site 767817009058 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817009059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817009060 active site 767817009061 phosphorylation site [posttranslational modification] 767817009062 intermolecular recognition site; other site 767817009063 dimerization interface [polypeptide binding]; other site 767817009064 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817009065 DNA binding site [nucleotide binding] 767817009066 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 767817009067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817009068 Walker A/P-loop; other site 767817009069 ATP binding site [chemical binding]; other site 767817009070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817009071 Walker B; other site 767817009072 D-loop; other site 767817009073 H-loop/switch region; other site 767817009074 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 767817009075 putative active site [active] 767817009076 putative metal-binding site [ion binding]; other site 767817009077 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 767817009078 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 767817009079 NAD binding site [chemical binding]; other site 767817009080 homodimer interface [polypeptide binding]; other site 767817009081 active site 767817009082 substrate binding site [chemical binding]; other site 767817009083 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 767817009084 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 767817009085 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 767817009086 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 767817009087 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 767817009088 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 767817009089 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 767817009090 active site 767817009091 catalytic site [active] 767817009092 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 767817009093 DNA polymerase IV; Reviewed; Region: PRK03103 767817009094 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 767817009095 active site 767817009096 DNA binding site [nucleotide binding] 767817009097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767817009098 TPR motif; other site 767817009099 binding surface 767817009100 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 767817009101 active site 767817009102 metal binding site [ion binding]; metal-binding site 767817009103 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 767817009104 Asp23 family; Region: Asp23; pfam03780 767817009105 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 767817009106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817009107 Walker A motif; other site 767817009108 ATP binding site [chemical binding]; other site 767817009109 Walker B motif; other site 767817009110 arginine finger; other site 767817009111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817009112 Walker A motif; other site 767817009113 ATP binding site [chemical binding]; other site 767817009114 Walker B motif; other site 767817009115 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 767817009116 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 767817009117 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 767817009118 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 767817009119 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 767817009120 HSP70 interaction site [polypeptide binding]; other site 767817009121 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 767817009122 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 767817009123 dimer interface [polypeptide binding]; other site 767817009124 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 767817009125 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 767817009126 nucleotide binding site [chemical binding]; other site 767817009127 NEF interaction site [polypeptide binding]; other site 767817009128 SBD interface [polypeptide binding]; other site 767817009129 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767817009130 Ligand Binding Site [chemical binding]; other site 767817009131 HTH domain; Region: HTH_11; cl17392 767817009132 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 767817009133 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767817009134 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 767817009135 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 767817009136 Rubredoxin; Region: Rubredoxin; pfam00301 767817009137 iron binding site [ion binding]; other site 767817009138 Rubrerythrin [Energy production and conversion]; Region: COG1592 767817009139 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 767817009140 binuclear metal center [ion binding]; other site 767817009141 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 767817009142 iron binding site [ion binding]; other site 767817009143 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 767817009144 Rubredoxin; Region: Rubredoxin; pfam00301 767817009145 iron binding site [ion binding]; other site 767817009146 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 767817009147 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 767817009148 non-heme iron binding site [ion binding]; other site 767817009149 dimer interface [polypeptide binding]; other site 767817009150 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 767817009151 non-heme iron binding site [ion binding]; other site 767817009152 dimer interface [polypeptide binding]; other site 767817009153 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 767817009154 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767817009155 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 767817009156 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767817009157 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767817009158 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 767817009159 Walker A/P-loop; other site 767817009160 ATP binding site [chemical binding]; other site 767817009161 Q-loop/lid; other site 767817009162 ABC transporter signature motif; other site 767817009163 Walker B; other site 767817009164 D-loop; other site 767817009165 H-loop/switch region; other site 767817009166 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767817009167 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767817009168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817009169 Walker A/P-loop; other site 767817009170 ATP binding site [chemical binding]; other site 767817009171 Q-loop/lid; other site 767817009172 ABC transporter signature motif; other site 767817009173 Walker B; other site 767817009174 D-loop; other site 767817009175 H-loop/switch region; other site 767817009176 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 767817009177 Outer spore coat protein E (CotE); Region: CotE; pfam10628 767817009178 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 767817009179 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 767817009180 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 767817009181 PYR/PP interface [polypeptide binding]; other site 767817009182 dimer interface [polypeptide binding]; other site 767817009183 TPP binding site [chemical binding]; other site 767817009184 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 767817009185 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 767817009186 TPP-binding site [chemical binding]; other site 767817009187 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 767817009188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767817009189 NAD(P) binding site [chemical binding]; other site 767817009190 active site 767817009191 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 767817009192 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817009193 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 767817009194 trimer interface [polypeptide binding]; other site 767817009195 active site 767817009196 substrate binding site [chemical binding]; other site 767817009197 CoA binding site [chemical binding]; other site 767817009198 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 767817009199 trimer interface [polypeptide binding]; other site 767817009200 active site 767817009201 substrate binding site [chemical binding]; other site 767817009202 CoA binding site [chemical binding]; other site 767817009203 acyl carrier protein; Provisional; Region: acpP; PRK00982 767817009204 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 767817009205 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 767817009206 dimer interface [polypeptide binding]; other site 767817009207 active site 767817009208 CoA binding pocket [chemical binding]; other site 767817009209 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767817009210 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817009211 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 767817009212 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 767817009213 inhibitor-cofactor binding pocket; inhibition site 767817009214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817009215 catalytic residue [active] 767817009216 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 767817009217 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 767817009218 substrate binding site; other site 767817009219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767817009220 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 767817009221 NAD(P) binding site [chemical binding]; other site 767817009222 active site 767817009223 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 767817009224 YcfA-like protein; Region: YcfA; pfam07927 767817009225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817009226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817009227 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767817009228 MarR family; Region: MarR; pfam01047 767817009229 Uncharacterized ArCR, COG2043; Region: DUF169; cl00894 767817009230 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767817009231 Predicted transcriptional regulators [Transcription]; Region: COG1695 767817009232 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 767817009233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817009234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817009235 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 767817009236 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767817009237 Walker A/P-loop; other site 767817009238 ATP binding site [chemical binding]; other site 767817009239 Q-loop/lid; other site 767817009240 ABC transporter signature motif; other site 767817009241 Walker B; other site 767817009242 D-loop; other site 767817009243 H-loop/switch region; other site 767817009244 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 767817009245 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 767817009246 Methyltransferase domain; Region: Methyltransf_23; pfam13489 767817009247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817009248 S-adenosylmethionine binding site [chemical binding]; other site 767817009249 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767817009250 transposase/IS protein; Provisional; Region: PRK09183 767817009251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817009252 Walker A motif; other site 767817009253 ATP binding site [chemical binding]; other site 767817009254 Walker B motif; other site 767817009255 arginine finger; other site 767817009256 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 767817009257 PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301 767817009258 nucleic acid-binding interface [nucleotide binding]; other site 767817009259 Predicted transcriptional regulators [Transcription]; Region: COG1695 767817009260 Transcriptional regulator PadR-like family; Region: PadR; cl17335 767817009261 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 767817009262 Erythromycin esterase; Region: Erythro_esteras; pfam05139 767817009263 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767817009264 MULE transposase domain; Region: MULE; pfam10551 767817009265 TRAM domain; Region: TRAM; pfam01938 767817009266 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 767817009267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817009268 S-adenosylmethionine binding site [chemical binding]; other site 767817009269 Uncharacterized conserved protein [Function unknown]; Region: COG0398 767817009270 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 767817009271 Uncharacterized conserved protein [Function unknown]; Region: COG2006 767817009272 Domain of unknown function (DUF362); Region: DUF362; pfam04015 767817009273 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 767817009274 Sugar fermentation stimulation protein; Region: SfsA; cl00647 767817009275 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 767817009276 Putative transposase; Region: Y2_Tnp; pfam04986 767817009277 integron integrase; Region: integrase_gron; TIGR02249 767817009278 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817009279 active site 767817009280 DNA binding site [nucleotide binding] 767817009281 Int/Topo IB signature motif; other site 767817009282 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767817009283 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 767817009284 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 767817009285 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 767817009286 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 767817009287 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767817009288 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817009289 non-specific DNA binding site [nucleotide binding]; other site 767817009290 salt bridge; other site 767817009291 sequence-specific DNA binding site [nucleotide binding]; other site 767817009292 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 767817009293 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 767817009294 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 767817009295 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 767817009296 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 767817009297 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 767817009298 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 767817009299 metal ion-dependent adhesion site (MIDAS); other site 767817009300 HD domain; Region: HD_3; cl17350 767817009301 Protein of unknown function (DUF429); Region: DUF429; pfam04250 767817009302 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 767817009303 putative ADP-ribose binding site [chemical binding]; other site 767817009304 putative active site [active] 767817009305 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 767817009306 additional DNA contacts [nucleotide binding]; other site 767817009307 mismatch recognition site; other site 767817009308 active site 767817009309 zinc binding site [ion binding]; other site 767817009310 DNA intercalation site [nucleotide binding]; other site 767817009311 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 767817009312 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 767817009313 homodimer interface [polypeptide binding]; other site 767817009314 putative active site [active] 767817009315 catalytic site [active] 767817009316 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 767817009317 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 767817009318 cofactor binding site; other site 767817009319 DNA binding site [nucleotide binding] 767817009320 substrate interaction site [chemical binding]; other site 767817009321 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 767817009322 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767817009323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817009324 non-specific DNA binding site [nucleotide binding]; other site 767817009325 salt bridge; other site 767817009326 sequence-specific DNA binding site [nucleotide binding]; other site 767817009327 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 767817009328 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 767817009329 catalytic residues [active] 767817009330 catalytic nucleophile [active] 767817009331 Recombinase; Region: Recombinase; pfam07508 767817009332 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 767817009333 Recombinase; Region: Recombinase; pfam07508 767817009334 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 767817009335 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 767817009336 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 767817009337 catalytic residues [active] 767817009338 catalytic nucleophile [active] 767817009339 Recombinase; Region: Recombinase; pfam07508 767817009340 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 767817009341 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 767817009342 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 767817009343 catalytic residues [active] 767817009344 catalytic nucleophile [active] 767817009345 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767817009346 GEMM cis-regulatory element; Desgi_3524; IMG reference gene:2508514489 767817009347 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767817009348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817009349 non-specific DNA binding site [nucleotide binding]; other site 767817009350 salt bridge; other site 767817009351 sequence-specific DNA binding site [nucleotide binding]; other site 767817009352 Domain of unknown function (DUF955); Region: DUF955; pfam06114 767817009353 Cache domain; Region: Cache_1; pfam02743 767817009354 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 767817009355 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817009356 dimerization interface [polypeptide binding]; other site 767817009357 PAS domain S-box; Region: sensory_box; TIGR00229 767817009358 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817009359 putative active site [active] 767817009360 heme pocket [chemical binding]; other site 767817009361 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 767817009362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 767817009363 metal binding site [ion binding]; metal-binding site 767817009364 active site 767817009365 I-site; other site 767817009366 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817009367 Zn2+ binding site [ion binding]; other site 767817009368 Mg2+ binding site [ion binding]; other site 767817009369 DDE superfamily endonuclease; Region: DDE_5; cl17874 767817009370 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767817009371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817009372 PAS domain; Region: PAS_9; pfam13426 767817009373 putative active site [active] 767817009374 heme pocket [chemical binding]; other site 767817009375 PAS domain; Region: PAS_9; pfam13426 767817009376 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817009377 putative active site [active] 767817009378 heme pocket [chemical binding]; other site 767817009379 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 767817009380 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 767817009381 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817009382 Zn2+ binding site [ion binding]; other site 767817009383 Mg2+ binding site [ion binding]; other site 767817009384 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 767817009385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817009386 non-specific DNA binding site [nucleotide binding]; other site 767817009387 salt bridge; other site 767817009388 sequence-specific DNA binding site [nucleotide binding]; other site 767817009389 GEMM cis-regulatory element; Desgi_3536; IMG reference gene:2508514501 767817009390 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817009391 active site 767817009392 DNA binding site [nucleotide binding] 767817009393 Int/Topo IB signature motif; other site 767817009394 Helix-turn-helix domain; Region: HTH_36; pfam13730 767817009395 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 767817009396 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 767817009397 CHC2 zinc finger; Region: zf-CHC2; cl17510 767817009398 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 767817009399 Toprim-like; Region: Toprim_2; pfam13155 767817009400 active site 767817009401 metal binding site [ion binding]; metal-binding site 767817009402 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 767817009403 Sel1-like repeats; Region: SEL1; smart00671 767817009404 Sel1-like repeats; Region: SEL1; smart00671 767817009405 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 767817009406 Sel1-like repeats; Region: SEL1; smart00671 767817009407 Sel1-like repeats; Region: SEL1; smart00671 767817009408 Sel1-like repeats; Region: SEL1; smart00671 767817009409 Sel1-like repeats; Region: SEL1; smart00671 767817009410 Sel1-like repeats; Region: SEL1; smart00671 767817009411 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 767817009412 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 767817009413 Mg binding site [ion binding]; other site 767817009414 nucleotide binding site [chemical binding]; other site 767817009415 putative protofilament interface [polypeptide binding]; other site 767817009416 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 767817009417 putative active site pocket [active] 767817009418 dimerization interface [polypeptide binding]; other site 767817009419 putative catalytic residue [active] 767817009420 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 767817009421 AAA-like domain; Region: AAA_10; pfam12846 767817009422 Domain of unknown function DUF87; Region: DUF87; pfam01935 767817009423 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 767817009424 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 767817009425 cofactor binding site; other site 767817009426 DNA binding site [nucleotide binding] 767817009427 substrate interaction site [chemical binding]; other site 767817009428 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 767817009429 Protein of unknown function (DUF3852); Region: DUF3852; pfam12963 767817009430 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 767817009431 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 767817009432 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 767817009433 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 767817009434 Walker A motif; other site 767817009435 ATP binding site [chemical binding]; other site 767817009436 Walker B motif; other site 767817009437 AAA domain; Region: AAA_31; pfam13614 767817009438 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 767817009439 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 767817009440 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 767817009441 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 767817009442 SpoVG; Region: SpoVG; pfam04026 767817009443 YodL-like; Region: YodL; pfam14191 767817009444 S-layer homology domain; Region: SLH; pfam00395 767817009445 stage V sporulation protein T; Region: spore_V_T; TIGR02851 767817009446 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 767817009447 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 767817009448 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 767817009449 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767817009450 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 767817009451 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 767817009452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817009453 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 767817009454 Coenzyme A binding pocket [chemical binding]; other site 767817009455 TRAM domain; Region: TRAM; pfam01938 767817009456 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 767817009457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817009458 S-adenosylmethionine binding site [chemical binding]; other site 767817009459 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 767817009460 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 767817009461 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 767817009462 GAF domain; Region: GAF; pfam01590 767817009463 PAS domain; Region: PAS_9; pfam13426 767817009464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817009465 dimer interface [polypeptide binding]; other site 767817009466 phosphorylation site [posttranslational modification] 767817009467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817009468 ATP binding site [chemical binding]; other site 767817009469 Mg2+ binding site [ion binding]; other site 767817009470 G-X-G motif; other site 767817009471 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 767817009472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817009473 active site 767817009474 phosphorylation site [posttranslational modification] 767817009475 intermolecular recognition site; other site 767817009476 dimerization interface [polypeptide binding]; other site 767817009477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817009478 Walker A motif; other site 767817009479 ATP binding site [chemical binding]; other site 767817009480 Walker B motif; other site 767817009481 arginine finger; other site 767817009482 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 767817009483 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 767817009484 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 767817009485 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 767817009486 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 767817009487 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 767817009488 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 767817009489 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767817009490 MULE transposase domain; Region: MULE; pfam10551 767817009491 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 767817009492 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767817009493 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767817009494 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 767817009495 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 767817009496 DNA binding residues [nucleotide binding] 767817009497 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 767817009498 catalytic residues [active] 767817009499 catalytic nucleophile [active] 767817009500 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 767817009501 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 767817009502 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 767817009503 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 767817009504 minor groove reading motif; other site 767817009505 helix-hairpin-helix signature motif; other site 767817009506 substrate binding pocket [chemical binding]; other site 767817009507 active site 767817009508 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 767817009509 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 767817009510 DNA binding site [nucleotide binding] 767817009511 active site 767817009512 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 767817009513 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817009514 acyl-activating enzyme (AAE) consensus motif; other site 767817009515 AMP binding site [chemical binding]; other site 767817009516 active site 767817009517 CoA binding site [chemical binding]; other site 767817009518 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 767817009519 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 767817009520 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 767817009521 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 767817009522 dimer interface [polypeptide binding]; other site 767817009523 PYR/PP interface [polypeptide binding]; other site 767817009524 TPP binding site [chemical binding]; other site 767817009525 substrate binding site [chemical binding]; other site 767817009526 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 767817009527 TPP-binding site; other site 767817009528 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817009529 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 767817009530 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767817009531 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767817009532 Walker A/P-loop; other site 767817009533 ATP binding site [chemical binding]; other site 767817009534 Q-loop/lid; other site 767817009535 ABC transporter signature motif; other site 767817009536 Walker B; other site 767817009537 D-loop; other site 767817009538 H-loop/switch region; other site 767817009539 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767817009540 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767817009541 Walker A/P-loop; other site 767817009542 ATP binding site [chemical binding]; other site 767817009543 Q-loop/lid; other site 767817009544 ABC transporter signature motif; other site 767817009545 Walker B; other site 767817009546 D-loop; other site 767817009547 H-loop/switch region; other site 767817009548 Uncharacterized conserved protein [Function unknown]; Region: COG3937 767817009549 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 767817009550 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 767817009551 dimer interaction site [polypeptide binding]; other site 767817009552 substrate-binding tunnel; other site 767817009553 active site 767817009554 catalytic site [active] 767817009555 substrate binding site [chemical binding]; other site 767817009556 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 767817009557 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 767817009558 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 767817009559 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767817009560 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 767817009561 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 767817009562 NodB motif; other site 767817009563 active site 767817009564 catalytic site [active] 767817009565 metal binding site [ion binding]; metal-binding site 767817009566 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 767817009567 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767817009568 active site 767817009569 HIGH motif; other site 767817009570 nucleotide binding site [chemical binding]; other site 767817009571 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 767817009572 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 767817009573 active site 767817009574 KMSKS motif; other site 767817009575 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 767817009576 tRNA binding surface [nucleotide binding]; other site 767817009577 anticodon binding site; other site 767817009578 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 767817009579 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 767817009580 DivIVA protein; Region: DivIVA; pfam05103 767817009581 DivIVA domain; Region: DivI1A_domain; TIGR03544 767817009582 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 767817009583 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767817009584 RNA binding surface [nucleotide binding]; other site 767817009585 YGGT family; Region: YGGT; pfam02325 767817009586 pyrroline-5-carboxylate reductase; Region: PLN02688 767817009587 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 767817009588 Protein of unknown function (DUF552); Region: DUF552; pfam04472 767817009589 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 767817009590 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767817009591 catalytic residue [active] 767817009592 HlyD family secretion protein; Region: HlyD_2; pfam12700 767817009593 putative membrane fusion protein; Region: TIGR02828 767817009594 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 767817009595 PhoU domain; Region: PhoU; pfam01895 767817009596 PhoU domain; Region: PhoU; pfam01895 767817009597 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 767817009598 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 767817009599 Walker A/P-loop; other site 767817009600 ATP binding site [chemical binding]; other site 767817009601 Q-loop/lid; other site 767817009602 ABC transporter signature motif; other site 767817009603 Walker B; other site 767817009604 D-loop; other site 767817009605 H-loop/switch region; other site 767817009606 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 767817009607 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817009608 dimerization interface [polypeptide binding]; other site 767817009609 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 767817009610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817009611 putative active site [active] 767817009612 heme pocket [chemical binding]; other site 767817009613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817009614 dimer interface [polypeptide binding]; other site 767817009615 phosphorylation site [posttranslational modification] 767817009616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817009617 ATP binding site [chemical binding]; other site 767817009618 Mg2+ binding site [ion binding]; other site 767817009619 G-X-G motif; other site 767817009620 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817009621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817009622 active site 767817009623 phosphorylation site [posttranslational modification] 767817009624 intermolecular recognition site; other site 767817009625 dimerization interface [polypeptide binding]; other site 767817009626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817009627 DNA binding site [nucleotide binding] 767817009628 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 767817009629 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 767817009630 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 767817009631 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767817009632 Beta-Casp domain; Region: Beta-Casp; smart01027 767817009633 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 767817009634 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 767817009635 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 767817009636 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817009637 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 767817009638 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 767817009639 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817009640 FeS/SAM binding site; other site 767817009641 ATP cone domain; Region: ATP-cone; pfam03477 767817009642 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 767817009643 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 767817009644 thioester formation/cholesterol transfer; other site 767817009645 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 767817009646 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl16942 767817009647 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 767817009648 Class III ribonucleotide reductase; Region: RNR_III; cd01675 767817009649 active site 767817009650 effector binding site; other site 767817009651 Zn binding site [ion binding]; other site 767817009652 glycine loop; other site 767817009653 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 767817009654 ATP cone domain; Region: ATP-cone; pfam03477 767817009655 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 767817009656 sporulation sigma factor SigG; Reviewed; Region: PRK08215 767817009657 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817009658 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 767817009659 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817009660 DNA binding residues [nucleotide binding] 767817009661 sporulation sigma factor SigE; Reviewed; Region: PRK08301 767817009662 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817009663 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817009664 DNA binding residues [nucleotide binding] 767817009665 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 767817009666 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 767817009667 cell division protein FtsZ; Validated; Region: PRK09330 767817009668 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 767817009669 nucleotide binding site [chemical binding]; other site 767817009670 SulA interaction site; other site 767817009671 cell division protein FtsA; Region: ftsA; TIGR01174 767817009672 Cell division protein FtsA; Region: FtsA; smart00842 767817009673 Cell division protein FtsA; Region: FtsA; pfam14450 767817009674 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 767817009675 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 767817009676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 767817009677 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 767817009678 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 767817009679 Cell division protein FtsQ; Region: FtsQ; pfam03799 767817009680 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 767817009681 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 767817009682 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 767817009683 YcfA-like protein; Region: YcfA; pfam07927 767817009684 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 767817009685 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 767817009686 hinge; other site 767817009687 active site 767817009688 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 767817009689 FAD binding domain; Region: FAD_binding_4; pfam01565 767817009690 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 767817009691 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 767817009692 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767817009693 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767817009694 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767817009695 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 767817009696 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 767817009697 active site 767817009698 homodimer interface [polypeptide binding]; other site 767817009699 cell division protein FtsW; Region: ftsW; TIGR02614 767817009700 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 767817009701 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767817009702 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767817009703 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 767817009704 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 767817009705 Mg++ binding site [ion binding]; other site 767817009706 putative catalytic motif [active] 767817009707 putative substrate binding site [chemical binding]; other site 767817009708 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 767817009709 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767817009710 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767817009711 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767817009712 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 767817009713 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767817009714 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767817009715 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767817009716 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 767817009717 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 767817009718 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767817009719 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767817009720 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 767817009721 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 767817009722 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 767817009723 Cell division protein FtsL; Region: FtsL; cl11433 767817009724 MraW methylase family; Region: Methyltransf_5; pfam01795 767817009725 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 767817009726 cell division protein MraZ; Reviewed; Region: PRK00326 767817009727 MraZ protein; Region: MraZ; pfam02381 767817009728 MraZ protein; Region: MraZ; pfam02381 767817009729 histidinol-phosphatase; Provisional; Region: PRK07328 767817009730 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 767817009731 active site 767817009732 dimer interface [polypeptide binding]; other site 767817009733 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 767817009734 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 767817009735 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 767817009736 active site 767817009737 nucleophile elbow; other site 767817009738 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 767817009739 metal binding site 2 [ion binding]; metal-binding site 767817009740 putative DNA binding helix; other site 767817009741 metal binding site 1 [ion binding]; metal-binding site 767817009742 dimer interface [polypeptide binding]; other site 767817009743 structural Zn2+ binding site [ion binding]; other site 767817009744 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 767817009745 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 767817009746 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 767817009747 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 767817009748 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 767817009749 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 767817009750 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 767817009751 G1 box; other site 767817009752 GTP/Mg2+ binding site [chemical binding]; other site 767817009753 Switch I region; other site 767817009754 G2 box; other site 767817009755 G3 box; other site 767817009756 Switch II region; other site 767817009757 G4 box; other site 767817009758 G5 box; other site 767817009759 Nucleoside recognition; Region: Gate; pfam07670 767817009760 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 767817009761 Nucleoside recognition; Region: Gate; pfam07670 767817009762 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 767817009763 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 767817009764 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 767817009765 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 767817009766 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767817009767 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767817009768 transmembrane helices; other site 767817009769 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 767817009770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817009771 Response regulator receiver domain; Region: Response_reg; pfam00072 767817009772 active site 767817009773 phosphorylation site [posttranslational modification] 767817009774 intermolecular recognition site; other site 767817009775 dimerization interface [polypeptide binding]; other site 767817009776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817009777 HAMP domain; Region: HAMP; pfam00672 767817009778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817009779 dimer interface [polypeptide binding]; other site 767817009780 phosphorylation site [posttranslational modification] 767817009781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817009782 ATP binding site [chemical binding]; other site 767817009783 Mg2+ binding site [ion binding]; other site 767817009784 G-X-G motif; other site 767817009785 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 767817009786 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 767817009787 acyl-activating enzyme (AAE) consensus motif; other site 767817009788 putative AMP binding site [chemical binding]; other site 767817009789 putative active site [active] 767817009790 putative CoA binding site [chemical binding]; other site 767817009791 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 767817009792 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 767817009793 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 767817009794 protein binding site [polypeptide binding]; other site 767817009795 Transposase [DNA replication, recombination, and repair]; Region: COG5421 767817009796 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767817009797 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767817009798 transmembrane helices; other site 767817009799 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 767817009800 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 767817009801 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 767817009802 transmembrane helices; other site 767817009803 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 767817009804 Cysteine-rich domain; Region: CCG; pfam02754 767817009805 Cysteine-rich domain; Region: CCG; pfam02754 767817009806 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767817009807 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 767817009808 4Fe-4S binding domain; Region: Fer4_6; pfam12837 767817009809 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817009810 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 767817009811 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817009812 4Fe-4S binding domain; Region: Fer4; pfam00037 767817009813 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 767817009814 L-aspartate oxidase; Provisional; Region: PRK06175 767817009815 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 767817009816 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 767817009817 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817009818 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 767817009819 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 767817009820 ATP-sulfurylase; Region: ATPS; cd00517 767817009821 active site 767817009822 HXXH motif; other site 767817009823 flexible loop; other site 767817009824 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 767817009825 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 767817009826 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 767817009827 DsrC like protein; Region: DsrC; pfam04358 767817009828 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 767817009829 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 767817009830 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 767817009831 PhoU domain; Region: PhoU; pfam01895 767817009832 PhoU domain; Region: PhoU; pfam01895 767817009833 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 767817009834 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 767817009835 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 767817009836 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767817009837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817009838 Walker A/P-loop; other site 767817009839 ATP binding site [chemical binding]; other site 767817009840 Q-loop/lid; other site 767817009841 ABC transporter signature motif; other site 767817009842 Walker B; other site 767817009843 D-loop; other site 767817009844 H-loop/switch region; other site 767817009845 ABC transporter; Region: ABC_tran_2; pfam12848 767817009846 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767817009847 pyrophosphatase PpaX; Provisional; Region: PRK13288 767817009848 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767817009849 active site 767817009850 motif I; other site 767817009851 motif II; other site 767817009852 Protein of unknown function (DUF964); Region: DUF964; pfam06133 767817009853 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 767817009854 TrkA-C domain; Region: TrkA_C; pfam02080 767817009855 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 767817009856 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767817009857 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767817009858 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 767817009859 transmembrane helices; other site 767817009860 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 767817009861 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 767817009862 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 767817009863 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 767817009864 RNA binding site [nucleotide binding]; other site 767817009865 Uncharacterized conserved protein [Function unknown]; Region: COG1633 767817009866 Manganese catalase-like protein, ferritin-like diiron-binding domain; Region: Mn_catalase_like; cd07908 767817009867 dinuclear metal binding motif [ion binding]; other site 767817009868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767817009869 putative substrate translocation pore; other site 767817009870 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 767817009871 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 767817009872 4Fe-4S binding domain; Region: Fer4_5; pfam12801 767817009873 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 767817009874 catalytic residues [active] 767817009875 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767817009876 MarR family; Region: MarR; pfam01047 767817009877 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 767817009878 trimer interface [polypeptide binding]; other site 767817009879 putative Zn binding site [ion binding]; other site 767817009880 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767817009881 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817009882 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 767817009883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817009884 S-adenosylmethionine binding site [chemical binding]; other site 767817009885 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 767817009886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817009887 dimer interface [polypeptide binding]; other site 767817009888 conserved gate region; other site 767817009889 putative PBP binding loops; other site 767817009890 ABC-ATPase subunit interface; other site 767817009891 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 767817009892 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 767817009893 Walker A/P-loop; other site 767817009894 ATP binding site [chemical binding]; other site 767817009895 Q-loop/lid; other site 767817009896 ABC transporter signature motif; other site 767817009897 Walker B; other site 767817009898 D-loop; other site 767817009899 H-loop/switch region; other site 767817009900 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 767817009901 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 767817009902 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 767817009903 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 767817009904 putative dimer interface [polypeptide binding]; other site 767817009905 [2Fe-2S] cluster binding site [ion binding]; other site 767817009906 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 767817009907 dimer interface [polypeptide binding]; other site 767817009908 [2Fe-2S] cluster binding site [ion binding]; other site 767817009909 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 767817009910 SLBB domain; Region: SLBB; pfam10531 767817009911 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 767817009912 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817009913 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 767817009914 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817009915 catalytic loop [active] 767817009916 iron binding site [ion binding]; other site 767817009917 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 767817009918 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 767817009919 4Fe-4S binding domain; Region: Fer4; pfam00037 767817009920 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 767817009921 Ligand Binding Site [chemical binding]; other site 767817009922 TIGR00269 family protein; Region: TIGR00269 767817009923 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 767817009924 Membrane protein of unknown function; Region: DUF360; pfam04020 767817009925 Bifunctional nuclease; Region: DNase-RNase; pfam02577 767817009926 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 767817009927 GAF domain; Region: GAF_3; pfam13492 767817009928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817009929 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767817009930 dimer interface [polypeptide binding]; other site 767817009931 phosphorylation site [posttranslational modification] 767817009932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817009933 ATP binding site [chemical binding]; other site 767817009934 Mg2+ binding site [ion binding]; other site 767817009935 G-X-G motif; other site 767817009936 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 767817009937 Prephenate dehydratase; Region: PDT; pfam00800 767817009938 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 767817009939 putative L-Phe binding site [chemical binding]; other site 767817009940 Chorismate mutase type II; Region: CM_2; smart00830 767817009941 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 767817009942 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 767817009943 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 767817009944 CoA binding domain; Region: CoA_binding_2; pfam13380 767817009945 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 767817009946 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 767817009947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767817009948 binding surface 767817009949 TPR motif; other site 767817009950 Tetratricopeptide repeat; Region: TPR_12; pfam13424 767817009951 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 767817009952 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 767817009953 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767817009954 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 767817009955 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 767817009956 putative NAD(P) binding site [chemical binding]; other site 767817009957 active site 767817009958 Integral membrane protein DUF95; Region: DUF95; pfam01944 767817009959 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 767817009960 TrkA-N domain; Region: TrkA_N; pfam02254 767817009961 TrkA-C domain; Region: TrkA_C; pfam02080 767817009962 TrkA-N domain; Region: TrkA_N; pfam02254 767817009963 TrkA-C domain; Region: TrkA_C; pfam02080 767817009964 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 767817009965 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 767817009966 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 767817009967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767817009968 putative substrate translocation pore; other site 767817009969 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 767817009970 Predicted membrane protein [Function unknown]; Region: COG2323 767817009971 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 767817009972 putative homodimer interface [polypeptide binding]; other site 767817009973 putative active site pocket [active] 767817009974 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 767817009975 Probable zinc-binding domain; Region: zf-trcl; pfam13451 767817009976 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 767817009977 Septin family protein [Cell division and chromosome partitioning / Cytoskeleton]; Region: CDC3; COG5019 767817009978 EDD domain protein, DegV family; Region: DegV; TIGR00762 767817009979 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767817009980 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 767817009981 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 767817009982 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 767817009983 Walker A/P-loop; other site 767817009984 ATP binding site [chemical binding]; other site 767817009985 Q-loop/lid; other site 767817009986 ABC transporter signature motif; other site 767817009987 Walker B; other site 767817009988 D-loop; other site 767817009989 H-loop/switch region; other site 767817009990 NMT1/THI5 like; Region: NMT1; pfam09084 767817009991 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 767817009992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817009993 dimer interface [polypeptide binding]; other site 767817009994 conserved gate region; other site 767817009995 putative PBP binding loops; other site 767817009996 ABC-ATPase subunit interface; other site 767817009997 Domain of unknown function DUF77; Region: DUF77; pfam01910 767817009998 Thiamine pyrophosphokinase; Region: TPK; cd07995 767817009999 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 767817010000 active site 767817010001 dimerization interface [polypeptide binding]; other site 767817010002 thiamine binding site [chemical binding]; other site 767817010003 DsrE/DsrF-like family; Region: DrsE; cl00672 767817010004 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767817010005 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767817010006 Walker A/P-loop; other site 767817010007 ATP binding site [chemical binding]; other site 767817010008 Q-loop/lid; other site 767817010009 ABC transporter signature motif; other site 767817010010 Walker B; other site 767817010011 D-loop; other site 767817010012 H-loop/switch region; other site 767817010013 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 767817010014 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 767817010015 putative trimer interface [polypeptide binding]; other site 767817010016 putative CoA binding site [chemical binding]; other site 767817010017 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 767817010018 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 767817010019 Walker A/P-loop; other site 767817010020 ATP binding site [chemical binding]; other site 767817010021 Q-loop/lid; other site 767817010022 ABC transporter signature motif; other site 767817010023 Walker B; other site 767817010024 D-loop; other site 767817010025 H-loop/switch region; other site 767817010026 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 767817010027 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817010028 FeS/SAM binding site; other site 767817010029 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 767817010030 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 767817010031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817010032 S-adenosylmethionine binding site [chemical binding]; other site 767817010033 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 767817010034 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 767817010035 putative ligand binding residues [chemical binding]; other site 767817010036 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 767817010037 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 767817010038 ABC-ATPase subunit interface; other site 767817010039 dimer interface [polypeptide binding]; other site 767817010040 putative PBP binding regions; other site 767817010041 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 767817010042 Domain of unknown function (DUF364); Region: DUF364; pfam04016 767817010043 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 767817010044 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 767817010045 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 767817010046 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 767817010047 substrate binding site [chemical binding]; other site 767817010048 active site 767817010049 catalytic residues [active] 767817010050 heterodimer interface [polypeptide binding]; other site 767817010051 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 767817010052 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 767817010053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817010054 catalytic residue [active] 767817010055 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 767817010056 active site 767817010057 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 767817010058 active site 767817010059 ribulose/triose binding site [chemical binding]; other site 767817010060 phosphate binding site [ion binding]; other site 767817010061 substrate (anthranilate) binding pocket [chemical binding]; other site 767817010062 product (indole) binding pocket [chemical binding]; other site 767817010063 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 767817010064 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 767817010065 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 767817010066 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 767817010067 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 767817010068 glutamine binding [chemical binding]; other site 767817010069 catalytic triad [active] 767817010070 anthranilate synthase component I; Provisional; Region: PRK13565 767817010071 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 767817010072 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 767817010073 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 767817010074 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 767817010075 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 767817010076 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 767817010077 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767817010078 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 767817010079 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817010080 Zn2+ binding site [ion binding]; other site 767817010081 Mg2+ binding site [ion binding]; other site 767817010082 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 767817010083 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767817010084 Zn2+ binding site [ion binding]; other site 767817010085 Mg2+ binding site [ion binding]; other site 767817010086 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 767817010087 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 767817010088 CoA-transferase family III; Region: CoA_transf_3; pfam02515 767817010089 Rotavirus RNA-binding Protein 53 (NS53); Region: Rota_NS53; pfam00981 767817010090 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 767817010091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 767817010092 SCP-2 sterol transfer family; Region: SCP2; pfam02036 767817010093 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 767817010094 Family description; Region: UvrD_C_2; pfam13538 767817010095 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 767817010096 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 767817010097 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 767817010098 Sporulation and spore germination; Region: Germane; pfam10646 767817010099 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 767817010100 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 767817010101 active site 767817010102 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 767817010103 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 767817010104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 767817010105 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 767817010106 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 767817010107 FMN binding site [chemical binding]; other site 767817010108 substrate binding site [chemical binding]; other site 767817010109 putative catalytic residue [active] 767817010110 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 767817010111 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767817010112 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767817010113 active site 767817010114 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 767817010115 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 767817010116 active site 767817010117 metal binding site [ion binding]; metal-binding site 767817010118 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 767817010119 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 767817010120 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817010121 ATP binding site [chemical binding]; other site 767817010122 putative Mg++ binding site [ion binding]; other site 767817010123 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817010124 nucleotide binding region [chemical binding]; other site 767817010125 ATP-binding site [chemical binding]; other site 767817010126 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 767817010127 integron integrase; Region: integrase_gron; TIGR02249 767817010128 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817010129 active site 767817010130 Int/Topo IB signature motif; other site 767817010131 DNA binding site [nucleotide binding] 767817010132 Putative transposase; Region: Y2_Tnp; pfam04986 767817010133 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 767817010134 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 767817010135 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 767817010136 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 767817010137 putative FMN binding site [chemical binding]; other site 767817010138 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 767817010139 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 767817010140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817010141 S-adenosylmethionine binding site [chemical binding]; other site 767817010142 Predicted membrane protein [Function unknown]; Region: COG3428 767817010143 Bacterial PH domain; Region: DUF304; pfam03703 767817010144 Bacterial PH domain; Region: DUF304; pfam03703 767817010145 Bacterial PH domain; Region: DUF304; pfam03703 767817010146 Uncharacterized conserved protein [Function unknown]; Region: COG3402 767817010147 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 767817010148 Family description; Region: VCBS; pfam13517 767817010149 Family description; Region: VCBS; pfam13517 767817010150 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 767817010151 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 767817010152 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 767817010153 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 767817010154 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 767817010155 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 767817010156 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767817010157 MarR family; Region: MarR; pfam01047 767817010158 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 767817010159 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 767817010160 putative [Fe4-S4] binding site [ion binding]; other site 767817010161 putative molybdopterin cofactor binding site [chemical binding]; other site 767817010162 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 767817010163 molybdopterin cofactor binding site; other site 767817010164 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 767817010165 PAS domain; Region: PAS; smart00091 767817010166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817010167 Walker A motif; other site 767817010168 ATP binding site [chemical binding]; other site 767817010169 Walker B motif; other site 767817010170 arginine finger; other site 767817010171 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817010172 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 767817010173 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817010174 FeS/SAM binding site; other site 767817010175 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 767817010176 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 767817010177 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 767817010178 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 767817010179 dimer interface [polypeptide binding]; other site 767817010180 putative functional site; other site 767817010181 putative MPT binding site; other site 767817010182 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 767817010183 4Fe-4S binding domain; Region: Fer4; pfam00037 767817010184 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 767817010185 4Fe-4S binding domain; Region: Fer4; pfam00037 767817010186 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817010187 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767817010188 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 767817010189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767817010190 4Fe-4S binding domain; Region: Fer4; pfam00037 767817010191 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817010192 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 767817010193 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767817010194 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767817010195 Cysteine-rich domain; Region: CCG; pfam02754 767817010196 Cysteine-rich domain; Region: CCG; pfam02754 767817010197 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 767817010198 BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in...; Region: BAH; cl02608 767817010199 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 767817010200 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 767817010201 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 767817010202 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 767817010203 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817010204 catalytic loop [active] 767817010205 iron binding site [ion binding]; other site 767817010206 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 767817010207 4Fe-4S binding domain; Region: Fer4_6; pfam12837 767817010208 4Fe-4S binding domain; Region: Fer4; pfam00037 767817010209 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 767817010210 [4Fe-4S] binding site [ion binding]; other site 767817010211 molybdopterin cofactor binding site; other site 767817010212 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 767817010213 molybdopterin cofactor binding site; other site 767817010214 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 767817010215 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 767817010216 dimer interface [polypeptide binding]; other site 767817010217 putative functional site; other site 767817010218 putative MPT binding site; other site 767817010219 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 767817010220 PBP superfamily domain; Region: PBP_like_2; pfam12849 767817010221 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 767817010222 O-Antigen ligase; Region: Wzy_C; pfam04932 767817010223 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 767817010224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767817010225 binding surface 767817010226 TPR repeat; Region: TPR_11; pfam13414 767817010227 TPR motif; other site 767817010228 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 767817010229 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 767817010230 dimer interface [polypeptide binding]; other site 767817010231 putative CheW interface [polypeptide binding]; other site 767817010232 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 767817010233 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 767817010234 protein-splicing catalytic site; other site 767817010235 thioester formation/cholesterol transfer; other site 767817010236 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 767817010237 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 767817010238 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817010239 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817010240 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767817010241 Beta-lactamase; Region: Beta-lactamase; pfam00144 767817010242 DNA topoisomerase III; Provisional; Region: PRK07726 767817010243 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 767817010244 active site 767817010245 putative interdomain interaction site [polypeptide binding]; other site 767817010246 putative metal-binding site [ion binding]; other site 767817010247 putative nucleotide binding site [chemical binding]; other site 767817010248 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 767817010249 domain I; other site 767817010250 phosphate binding site [ion binding]; other site 767817010251 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 767817010252 domain III; other site 767817010253 nucleotide binding site [chemical binding]; other site 767817010254 DNA binding groove [nucleotide binding] 767817010255 catalytic site [active] 767817010256 domain II; other site 767817010257 domain IV; other site 767817010258 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 767817010259 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 767817010260 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 767817010261 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 767817010262 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 767817010263 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 767817010264 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 767817010265 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 767817010266 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 767817010267 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817010268 acyl-activating enzyme (AAE) consensus motif; other site 767817010269 AMP binding site [chemical binding]; other site 767817010270 active site 767817010271 CoA binding site [chemical binding]; other site 767817010272 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 767817010273 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 767817010274 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 767817010275 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 767817010276 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 767817010277 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 767817010278 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 767817010279 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 767817010280 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 767817010281 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 767817010282 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 767817010283 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817010284 FeS/SAM binding site; other site 767817010285 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 767817010286 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 767817010287 active site 767817010288 multimer interface [polypeptide binding]; other site 767817010289 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 767817010290 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 767817010291 inhibitor-cofactor binding pocket; inhibition site 767817010292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817010293 catalytic residue [active] 767817010294 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 767817010295 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 767817010296 hexamer interface [polypeptide binding]; other site 767817010297 ligand binding site [chemical binding]; other site 767817010298 putative active site [active] 767817010299 NAD(P) binding site [chemical binding]; other site 767817010300 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817010301 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 767817010302 catalytic loop [active] 767817010303 iron binding site [ion binding]; other site 767817010304 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 767817010305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767817010306 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 767817010307 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 767817010308 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 767817010309 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 767817010310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767817010311 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 767817010312 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 767817010313 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 767817010314 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 767817010315 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 767817010316 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 767817010317 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767817010318 catalytic residue [active] 767817010319 DsrC like protein; Region: DsrC; cl01101 767817010320 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 767817010321 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 767817010322 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 767817010323 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 767817010324 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 767817010325 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 767817010326 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 767817010327 inhibitor-cofactor binding pocket; inhibition site 767817010328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817010329 catalytic residue [active] 767817010330 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 767817010331 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 767817010332 B12 binding site [chemical binding]; other site 767817010333 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 767817010334 putative active site [active] 767817010335 heme pocket [chemical binding]; other site 767817010336 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 767817010337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817010338 Walker A motif; other site 767817010339 ATP binding site [chemical binding]; other site 767817010340 Walker B motif; other site 767817010341 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 767817010342 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 767817010343 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 767817010344 Malic enzyme, N-terminal domain; Region: malic; pfam00390 767817010345 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 767817010346 putative NAD(P) binding site [chemical binding]; other site 767817010347 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767817010348 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767817010349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767817010350 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 767817010351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817010352 putative active site [active] 767817010353 heme pocket [chemical binding]; other site 767817010354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817010355 Walker A motif; other site 767817010356 ATP binding site [chemical binding]; other site 767817010357 Walker B motif; other site 767817010358 arginine finger; other site 767817010359 pyrrolysine biosynthesis protein PylD; Region: pyrrolys_PylD; TIGR03911 767817010360 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 767817010361 phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468 767817010362 pyrrolysyl-tRNA synthetase, C-terminal region; Region: PylS_Cterm; TIGR02367 767817010363 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 767817010364 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 767817010365 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 767817010366 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 767817010367 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 767817010368 substrate binding pocket [chemical binding]; other site 767817010369 dimer interface [polypeptide binding]; other site 767817010370 inhibitor binding site; inhibition site 767817010371 pyrrolysyl-tRNA synthetase, N-terminal region; Region: PylS_Nterm; TIGR03912 767817010372 pyrrolysine biosynthesis protein PylC; Region: pyrrolys_PylC; TIGR03909 767817010373 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 767817010374 pyrrolysine biosynthesis radical SAM protein; Region: pyrrolys_PylB; TIGR03910 767817010375 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817010376 FeS/SAM binding site; other site 767817010377 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 767817010378 Transposase domain (DUF772); Region: DUF772; pfam05598 767817010379 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767817010380 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 767817010381 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 767817010382 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 767817010383 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 767817010384 Winged helix-turn helix; Region: HTH_29; pfam13551 767817010385 Homeodomain-like domain; Region: HTH_32; pfam13565 767817010386 transposase/IS protein; Provisional; Region: PRK09183 767817010387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817010388 Walker A motif; other site 767817010389 ATP binding site [chemical binding]; other site 767817010390 Walker B motif; other site 767817010391 arginine finger; other site 767817010392 Transposase [DNA replication, recombination, and repair]; Region: COG5421 767817010393 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 767817010394 active site 767817010395 catalytic triad [active] 767817010396 agmatinase; Region: agmatinase; TIGR01230 767817010397 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 767817010398 putative active site [active] 767817010399 Mn binding site [ion binding]; other site 767817010400 spermidine synthase; Provisional; Region: PRK00811 767817010401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817010402 S-adenosylmethionine binding site [chemical binding]; other site 767817010403 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 767817010404 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 767817010405 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 767817010406 Metal-binding active site; metal-binding site 767817010407 AP (apurinic/apyrimidinic) site pocket; other site 767817010408 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 767817010409 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 767817010410 peptide binding site [polypeptide binding]; other site 767817010411 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 767817010412 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817010413 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 767817010414 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 767817010415 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 767817010416 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 767817010417 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767817010418 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 767817010419 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 767817010420 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 767817010421 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 767817010422 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817010423 catalytic loop [active] 767817010424 iron binding site [ion binding]; other site 767817010425 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 767817010426 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 767817010427 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 767817010428 Predicted transcriptional regulators [Transcription]; Region: COG1695 767817010429 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 767817010430 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 767817010431 putative MPT binding site; other site 767817010432 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 767817010433 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 767817010434 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 767817010435 XdhC Rossmann domain; Region: XdhC_C; pfam13478 767817010436 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 767817010437 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 767817010438 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 767817010439 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 767817010440 Ligand binding site; other site 767817010441 metal-binding site 767817010442 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 767817010443 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 767817010444 Transcriptional regulator [Transcription]; Region: IclR; COG1414 767817010445 Bacterial transcriptional regulator; Region: IclR; pfam01614 767817010446 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 767817010447 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 767817010448 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 767817010449 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 767817010450 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817010451 catalytic loop [active] 767817010452 iron binding site [ion binding]; other site 767817010453 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 767817010454 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 767817010455 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 767817010456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817010457 regulatory ATPase RavA; Provisional; Region: PRK13531 767817010458 Walker A motif; other site 767817010459 ATP binding site [chemical binding]; other site 767817010460 Walker B motif; other site 767817010461 arginine finger; other site 767817010462 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 767817010463 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 767817010464 metal ion-dependent adhesion site (MIDAS); other site 767817010465 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 767817010466 active site 767817010467 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 767817010468 Flavoprotein; Region: Flavoprotein; pfam02441 767817010469 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 767817010470 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 767817010471 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817010472 acyl-activating enzyme (AAE) consensus motif; other site 767817010473 AMP binding site [chemical binding]; other site 767817010474 active site 767817010475 CoA binding site [chemical binding]; other site 767817010476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 767817010477 Activator of aromatic catabolism; Region: XylR_N; pfam06505 767817010478 V4R domain; Region: V4R; pfam02830 767817010479 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 767817010480 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 767817010481 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 767817010482 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817010483 acyl-activating enzyme (AAE) consensus motif; other site 767817010484 AMP binding site [chemical binding]; other site 767817010485 active site 767817010486 CoA binding site [chemical binding]; other site 767817010487 FOG: CBS domain [General function prediction only]; Region: COG0517 767817010488 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 767817010489 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 767817010490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817010491 Walker A motif; other site 767817010492 ATP binding site [chemical binding]; other site 767817010493 Walker B motif; other site 767817010494 arginine finger; other site 767817010495 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817010496 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767817010497 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767817010498 transmembrane helices; other site 767817010499 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817010500 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 767817010501 acyl-activating enzyme (AAE) consensus motif; other site 767817010502 AMP binding site [chemical binding]; other site 767817010503 active site 767817010504 CoA binding site [chemical binding]; other site 767817010505 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 767817010506 Fe-S cluster binding site [ion binding]; other site 767817010507 active site 767817010508 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 767817010509 putative homodimer interface [polypeptide binding]; other site 767817010510 putative active site pocket [active] 767817010511 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 767817010512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 767817010513 Uncharacterized conserved protein [Function unknown]; Region: COG1543 767817010514 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 767817010515 active site 767817010516 substrate binding site [chemical binding]; other site 767817010517 catalytic site [active] 767817010518 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 767817010519 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817010520 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767817010521 stage V sporulation protein T; Region: spore_V_T; TIGR02851 767817010522 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 767817010523 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 767817010524 Iron-sulfur protein interface; other site 767817010525 proximal heme binding site [chemical binding]; other site 767817010526 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 767817010527 distal heme binding site [chemical binding]; other site 767817010528 dimer interface [polypeptide binding]; other site 767817010529 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 767817010530 L-aspartate oxidase; Provisional; Region: PRK06175 767817010531 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 767817010532 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 767817010533 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 767817010534 Coat F domain; Region: Coat_F; pfam07875 767817010535 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767817010536 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767817010537 ligand binding site [chemical binding]; other site 767817010538 flexible hinge region; other site 767817010539 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 767817010540 putative switch regulator; other site 767817010541 non-specific DNA interactions [nucleotide binding]; other site 767817010542 DNA binding site [nucleotide binding] 767817010543 sequence specific DNA binding site [nucleotide binding]; other site 767817010544 putative cAMP binding site [chemical binding]; other site 767817010545 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767817010546 putative DNA binding site [nucleotide binding]; other site 767817010547 dimerization interface [polypeptide binding]; other site 767817010548 putative Zn2+ binding site [ion binding]; other site 767817010549 Predicted permease; Region: DUF318; cl17795 767817010550 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 767817010551 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 767817010552 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 767817010553 putative [Fe4-S4] binding site [ion binding]; other site 767817010554 putative molybdopterin cofactor binding site [chemical binding]; other site 767817010555 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 767817010556 putative molybdopterin cofactor binding site; other site 767817010557 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817010558 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 767817010559 FMN binding site [chemical binding]; other site 767817010560 dimer interface [polypeptide binding]; other site 767817010561 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 767817010562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767817010563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767817010564 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767817010565 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 767817010566 active site residue [active] 767817010567 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767817010568 DNA-binding site [nucleotide binding]; DNA binding site 767817010569 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767817010570 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767817010571 Walker A/P-loop; other site 767817010572 ATP binding site [chemical binding]; other site 767817010573 Q-loop/lid; other site 767817010574 ABC transporter signature motif; other site 767817010575 Walker B; other site 767817010576 D-loop; other site 767817010577 H-loop/switch region; other site 767817010578 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 767817010579 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 767817010580 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 767817010581 acyl-activating enzyme (AAE) consensus motif; other site 767817010582 AMP binding site [chemical binding]; other site 767817010583 active site 767817010584 CoA binding site [chemical binding]; other site 767817010585 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767817010586 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 767817010587 active site 767817010588 enoyl-CoA hydratase; Provisional; Region: PRK07658 767817010589 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817010590 substrate binding site [chemical binding]; other site 767817010591 oxyanion hole (OAH) forming residues; other site 767817010592 trimer interface [polypeptide binding]; other site 767817010593 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 767817010594 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 767817010595 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 767817010596 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 767817010597 putative acyltransferase; Provisional; Region: PRK05790 767817010598 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 767817010599 dimer interface [polypeptide binding]; other site 767817010600 active site 767817010601 Activator of aromatic catabolism; Region: XylR_N; pfam06505 767817010602 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 767817010603 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 767817010604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817010605 dimer interface [polypeptide binding]; other site 767817010606 conserved gate region; other site 767817010607 putative PBP binding loops; other site 767817010608 ABC-ATPase subunit interface; other site 767817010609 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 767817010610 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 767817010611 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 767817010612 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767817010613 substrate binding pocket [chemical binding]; other site 767817010614 membrane-bound complex binding site; other site 767817010615 hinge residues; other site 767817010616 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 767817010617 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 767817010618 Walker A/P-loop; other site 767817010619 ATP binding site [chemical binding]; other site 767817010620 Q-loop/lid; other site 767817010621 ABC transporter signature motif; other site 767817010622 Walker B; other site 767817010623 D-loop; other site 767817010624 H-loop/switch region; other site 767817010625 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 767817010626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767817010627 dimer interface [polypeptide binding]; other site 767817010628 conserved gate region; other site 767817010629 putative PBP binding loops; other site 767817010630 ABC-ATPase subunit interface; other site 767817010631 Domain of unknown function DUF21; Region: DUF21; pfam01595 767817010632 FOG: CBS domain [General function prediction only]; Region: COG0517 767817010633 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 767817010634 Transporter associated domain; Region: CorC_HlyC; smart01091 767817010635 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 767817010636 Domain of unknown function DUF21; Region: DUF21; pfam01595 767817010637 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 767817010638 Transporter associated domain; Region: CorC_HlyC; smart01091 767817010639 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817010640 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 767817010641 putative ADP-binding pocket [chemical binding]; other site 767817010642 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817010643 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817010644 Holin family; Region: Phage_holin_4; pfam05105 767817010645 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767817010646 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817010647 DNA binding residues [nucleotide binding] 767817010648 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 767817010649 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817010650 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817010651 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 767817010652 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767817010653 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817010654 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817010655 DNA binding residues [nucleotide binding] 767817010656 Stage II sporulation protein; Region: SpoIID; pfam08486 767817010657 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 767817010658 dimer interface [polypeptide binding]; other site 767817010659 putative CheW interface [polypeptide binding]; other site 767817010660 Uncharacterized conserved protein [Function unknown]; Region: COG4279 767817010661 SWIM zinc finger; Region: SWIM; pfam04434 767817010662 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 767817010663 SNF2 Helicase protein; Region: DUF3670; pfam12419 767817010664 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 767817010665 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817010666 ATP binding site [chemical binding]; other site 767817010667 putative Mg++ binding site [ion binding]; other site 767817010668 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817010669 nucleotide binding region [chemical binding]; other site 767817010670 ATP-binding site [chemical binding]; other site 767817010671 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 767817010672 Predicted nucleotidyltransferases [General function prediction only]; Region: COG1708 767817010673 active site 767817010674 NTP binding site [chemical binding]; other site 767817010675 metal binding triad [ion binding]; metal-binding site 767817010676 HEPN domain; Region: HEPN; pfam05168 767817010677 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 767817010678 active site 767817010679 SUMO-1 interface [polypeptide binding]; other site 767817010680 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 767817010681 Holin family; Region: Phage_holin_4; pfam05105 767817010682 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 767817010683 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 767817010684 TIGR02594 family protein; Region: TIGR02594 767817010685 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 767817010686 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 767817010687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767817010688 DNA-binding site [nucleotide binding]; DNA binding site 767817010689 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767817010690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817010691 homodimer interface [polypeptide binding]; other site 767817010692 catalytic residue [active] 767817010693 EamA-like transporter family; Region: EamA; pfam00892 767817010694 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 767817010695 EamA-like transporter family; Region: EamA; pfam00892 767817010696 Predicted ATPase [General function prediction only]; Region: COG4637 767817010697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817010698 Walker A/P-loop; other site 767817010699 ATP binding site [chemical binding]; other site 767817010700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817010701 ATP binding site [chemical binding]; other site 767817010702 Q-loop/lid; other site 767817010703 ABC transporter signature motif; other site 767817010704 Walker B; other site 767817010705 D-loop; other site 767817010706 H-loop/switch region; other site 767817010707 Transposase domain (DUF772); Region: DUF772; pfam05598 767817010708 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767817010709 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767817010710 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767817010711 ligand binding site [chemical binding]; other site 767817010712 flexible hinge region; other site 767817010713 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 767817010714 non-specific DNA interactions [nucleotide binding]; other site 767817010715 DNA binding site [nucleotide binding] 767817010716 sequence specific DNA binding site [nucleotide binding]; other site 767817010717 putative cAMP binding site [chemical binding]; other site 767817010718 Uncharacterized conserved protein [Function unknown]; Region: COG1751 767817010719 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 767817010720 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 767817010721 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 767817010722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767817010723 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767817010724 putative substrate translocation pore; other site 767817010725 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817010726 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 767817010727 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 767817010728 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 767817010729 G1 box; other site 767817010730 putative GEF interaction site [polypeptide binding]; other site 767817010731 GTP/Mg2+ binding site [chemical binding]; other site 767817010732 Switch I region; other site 767817010733 G2 box; other site 767817010734 G3 box; other site 767817010735 Switch II region; other site 767817010736 G4 box; other site 767817010737 G5 box; other site 767817010738 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 767817010739 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 767817010740 RadC-like JAB domain; Region: RadC; pfam04002 767817010741 Uncharacterized conserved protein [Function unknown]; Region: COG1683 767817010742 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 767817010743 GIY-YIG motif/motif A; other site 767817010744 putative active site [active] 767817010745 putative metal binding site [ion binding]; other site 767817010746 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 767817010747 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 767817010748 active site 767817010749 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817010750 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767817010751 NlpC/P60 family; Region: NLPC_P60; pfam00877 767817010752 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767817010753 active site 767817010754 Protein of unknown function (DUF763); Region: DUF763; pfam05559 767817010755 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 767817010756 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 767817010757 nucleotide binding site/active site [active] 767817010758 HIT family signature motif; other site 767817010759 catalytic residue [active] 767817010760 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 767817010761 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817010762 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 767817010763 Flagellin N-methylase; Region: FliB; pfam03692 767817010764 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 767817010765 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 767817010766 acyl-activating enzyme (AAE) consensus motif; other site 767817010767 putative AMP binding site [chemical binding]; other site 767817010768 putative active site [active] 767817010769 putative CoA binding site [chemical binding]; other site 767817010770 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767817010771 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 767817010772 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 767817010773 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767817010774 putative active site [active] 767817010775 putative metal binding site [ion binding]; other site 767817010776 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 767817010777 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767817010778 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 767817010779 active site 767817010780 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 767817010781 4Fe-4S binding domain; Region: Fer4; pfam00037 767817010782 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817010783 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 767817010784 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 767817010785 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 767817010786 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 767817010787 decamer (pentamer of dimers) interface [polypeptide binding]; other site 767817010788 dimer interface [polypeptide binding]; other site 767817010789 peroxidatic and resolving cysteines [active] 767817010790 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 767817010791 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 767817010792 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 767817010793 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767817010794 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767817010795 Walker A/P-loop; other site 767817010796 ATP binding site [chemical binding]; other site 767817010797 Q-loop/lid; other site 767817010798 ABC transporter signature motif; other site 767817010799 Walker B; other site 767817010800 D-loop; other site 767817010801 H-loop/switch region; other site 767817010802 Predicted transcriptional regulators [Transcription]; Region: COG1725 767817010803 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767817010804 DNA-binding site [nucleotide binding]; DNA binding site 767817010805 oligoendopeptidase F; Region: pepF; TIGR00181 767817010806 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 767817010807 active site 767817010808 Zn binding site [ion binding]; other site 767817010809 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 767817010810 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 767817010811 Mechanosensitive ion channel; Region: MS_channel; pfam00924 767817010812 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 767817010813 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767817010814 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767817010815 active site 767817010816 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 767817010817 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 767817010818 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 767817010819 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 767817010820 active site 767817010821 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 767817010822 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 767817010823 putative NAD(P) binding site [chemical binding]; other site 767817010824 catalytic Zn binding site [ion binding]; other site 767817010825 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 767817010826 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 767817010827 putative active site; other site 767817010828 catalytic residue [active] 767817010829 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 767817010830 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 767817010831 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 767817010832 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 767817010833 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817010834 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 767817010835 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 767817010836 active site 767817010837 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 767817010838 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 767817010839 substrate-cofactor binding pocket; other site 767817010840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817010841 catalytic residue [active] 767817010842 AAA domain; Region: AAA_26; pfam13500 767817010843 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 767817010844 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 767817010845 ADP binding site [chemical binding]; other site 767817010846 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 767817010847 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 767817010848 inhibitor-cofactor binding pocket; inhibition site 767817010849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817010850 catalytic residue [active] 767817010851 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 767817010852 TIGR04076 family protein; Region: TIGR04076 767817010853 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 767817010854 TrkA-N domain; Region: TrkA_N; pfam02254 767817010855 TrkA-C domain; Region: TrkA_C; pfam02080 767817010856 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 767817010857 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 767817010858 Methyltransferase domain; Region: Methyltransf_31; pfam13847 767817010859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817010860 S-adenosylmethionine binding site [chemical binding]; other site 767817010861 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 767817010862 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767817010863 active site 767817010864 metal binding site [ion binding]; metal-binding site 767817010865 homotetramer interface [polypeptide binding]; other site 767817010866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767817010867 dimerization interface [polypeptide binding]; other site 767817010868 putative DNA binding site [nucleotide binding]; other site 767817010869 putative Zn2+ binding site [ion binding]; other site 767817010870 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 767817010871 arsenical-resistance protein; Region: acr3; TIGR00832 767817010872 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 767817010873 core domain interface [polypeptide binding]; other site 767817010874 delta subunit interface [polypeptide binding]; other site 767817010875 epsilon subunit interface [polypeptide binding]; other site 767817010876 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 767817010877 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 767817010878 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 767817010879 Walker A motif; other site 767817010880 ATP binding site [chemical binding]; other site 767817010881 Walker B motif; other site 767817010882 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 767817010883 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 767817010884 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 767817010885 alternate F1F0 ATPase, F0 subunit C; Region: alt_F1F0_F0_C; TIGR03322 767817010886 alternate F1F0 ATPase, F0 subunit A; Region: altF1_A; TIGR03306 767817010887 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 767817010888 N-ATPase, AtpR subunit; Region: AtpR; pfam12966 767817010889 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 767817010890 F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228 767817010891 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 767817010892 gamma subunit interface [polypeptide binding]; other site 767817010893 epsilon subunit interface [polypeptide binding]; other site 767817010894 LBP interface [polypeptide binding]; other site 767817010895 alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305 767817010896 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 767817010897 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 767817010898 alpha subunit interaction interface [polypeptide binding]; other site 767817010899 Walker A motif; other site 767817010900 ATP binding site [chemical binding]; other site 767817010901 Walker B motif; other site 767817010902 inhibitor binding site; inhibition site 767817010903 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 767817010904 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767817010905 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 767817010906 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 767817010907 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 767817010908 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 767817010909 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 767817010910 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 767817010911 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 767817010912 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 767817010913 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 767817010914 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767817010915 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817010916 dimerization interface [polypeptide binding]; other site 767817010917 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 767817010918 dimer interface [polypeptide binding]; other site 767817010919 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 767817010920 putative CheW interface [polypeptide binding]; other site 767817010921 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767817010922 dimerization interface [polypeptide binding]; other site 767817010923 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 767817010924 dimer interface [polypeptide binding]; other site 767817010925 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 767817010926 putative CheW interface [polypeptide binding]; other site 767817010927 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 767817010928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817010929 PAS domain; Region: PAS_9; pfam13426 767817010930 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 767817010931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817010932 Walker A motif; other site 767817010933 ATP binding site [chemical binding]; other site 767817010934 Walker B motif; other site 767817010935 arginine finger; other site 767817010936 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817010937 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 767817010938 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 767817010939 tetramer interface [polypeptide binding]; other site 767817010940 TPP-binding site [chemical binding]; other site 767817010941 heterodimer interface [polypeptide binding]; other site 767817010942 phosphorylation loop region [posttranslational modification] 767817010943 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 767817010944 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 767817010945 alpha subunit interface [polypeptide binding]; other site 767817010946 TPP binding site [chemical binding]; other site 767817010947 heterodimer interface [polypeptide binding]; other site 767817010948 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767817010949 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 767817010950 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 767817010951 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 767817010952 E3 interaction surface; other site 767817010953 lipoyl attachment site [posttranslational modification]; other site 767817010954 e3 binding domain; Region: E3_binding; pfam02817 767817010955 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 767817010956 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 767817010957 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 767817010958 lipoyl synthase; Provisional; Region: PRK05481 767817010959 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817010960 FeS/SAM binding site; other site 767817010961 Methyltransferase domain; Region: Methyltransf_31; pfam13847 767817010962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817010963 S-adenosylmethionine binding site [chemical binding]; other site 767817010964 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 767817010965 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 767817010966 active site 767817010967 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767817010968 active site 767817010969 Flavodoxin domain; Region: Flavodoxin_5; cl17428 767817010970 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 767817010971 4Fe-4S binding domain; Region: Fer4; pfam00037 767817010972 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 767817010973 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 767817010974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817010975 S-adenosylmethionine binding site [chemical binding]; other site 767817010976 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 767817010977 Predicted GTPases [General function prediction only]; Region: COG1162 767817010978 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 767817010979 RNA binding site [nucleotide binding]; other site 767817010980 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 767817010981 GTPase/Zn-binding domain interface [polypeptide binding]; other site 767817010982 GTP/Mg2+ binding site [chemical binding]; other site 767817010983 G4 box; other site 767817010984 G5 box; other site 767817010985 G1 box; other site 767817010986 Switch I region; other site 767817010987 G2 box; other site 767817010988 G3 box; other site 767817010989 Switch II region; other site 767817010990 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 767817010991 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 767817010992 DNA binding residues [nucleotide binding] 767817010993 Putative zinc-finger; Region: zf-HC2; pfam13490 767817010994 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 767817010995 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 767817010996 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817010997 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817010998 DNA binding residues [nucleotide binding] 767817010999 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 767817011000 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 767817011001 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 767817011002 putative active site [active] 767817011003 putative metal binding site [ion binding]; other site 767817011004 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767817011005 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 767817011006 RNA binding surface [nucleotide binding]; other site 767817011007 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767817011008 active site 767817011009 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 767817011010 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767817011011 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 767817011012 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767817011013 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 767817011014 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 767817011015 DNA binding residues [nucleotide binding] 767817011016 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 767817011017 catalytic residues [active] 767817011018 catalytic nucleophile [active] 767817011019 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 767817011020 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 767817011021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817011022 Coenzyme A binding pocket [chemical binding]; other site 767817011023 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 767817011024 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 767817011025 nickel binding site [ion binding]; other site 767817011026 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 767817011027 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 767817011028 transmembrane helices; other site 767817011029 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 767817011030 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 767817011031 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 767817011032 Walker A/P-loop; other site 767817011033 ATP binding site [chemical binding]; other site 767817011034 Q-loop/lid; other site 767817011035 ABC transporter signature motif; other site 767817011036 Walker B; other site 767817011037 D-loop; other site 767817011038 H-loop/switch region; other site 767817011039 Predicted transcriptional regulators [Transcription]; Region: COG1695 767817011040 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 767817011041 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 767817011042 L-lactate permease; Region: Lactate_perm; cl00701 767817011043 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767817011044 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767817011045 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 767817011046 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767817011047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767817011048 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 767817011049 putative dimerization interface [polypeptide binding]; other site 767817011050 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 767817011051 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 767817011052 DNA binding residues [nucleotide binding] 767817011053 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 767817011054 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 767817011055 GIY-YIG motif/motif A; other site 767817011056 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767817011057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767817011058 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 767817011059 putative dimerization interface [polypeptide binding]; other site 767817011060 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 767817011061 HSP70 interaction site [polypeptide binding]; other site 767817011062 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767817011063 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767817011064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767817011065 selenophosphate synthetase; Provisional; Region: PRK00943 767817011066 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 767817011067 dimerization interface [polypeptide binding]; other site 767817011068 putative ATP binding site [chemical binding]; other site 767817011069 Divergent AAA domain; Region: AAA_4; pfam04326 767817011070 Restriction endonuclease [Defense mechanisms]; Region: COG3587 767817011071 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767817011072 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 767817011073 DNA methylase; Region: N6_N4_Mtase; pfam01555 767817011074 DNA methylase; Region: N6_N4_Mtase; pfam01555 767817011075 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 767817011076 homodimer interface [polypeptide binding]; other site 767817011077 chemical substrate binding site [chemical binding]; other site 767817011078 oligomer interface [polypeptide binding]; other site 767817011079 metal binding site [ion binding]; metal-binding site 767817011080 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 767817011081 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817011082 ATP binding site [chemical binding]; other site 767817011083 putative Mg++ binding site [ion binding]; other site 767817011084 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817011085 nucleotide binding region [chemical binding]; other site 767817011086 ATP-binding site [chemical binding]; other site 767817011087 Predicted integral membrane protein [Function unknown]; Region: COG5615 767817011088 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 767817011089 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 767817011090 active site 767817011091 HIGH motif; other site 767817011092 dimer interface [polypeptide binding]; other site 767817011093 KMSKS motif; other site 767817011094 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767817011095 RNA binding surface [nucleotide binding]; other site 767817011096 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817011097 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 767817011098 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 767817011099 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 767817011100 Bacterial Ig-like domain; Region: Big_5; pfam13205 767817011101 Bacterial Ig-like domain; Region: Big_5; pfam13205 767817011102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 767817011103 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767817011104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817011105 PAS domain; Region: PAS_9; pfam13426 767817011106 putative active site [active] 767817011107 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 767817011108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817011109 Walker A motif; other site 767817011110 ATP binding site [chemical binding]; other site 767817011111 Walker B motif; other site 767817011112 arginine finger; other site 767817011113 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817011114 Putative Fe-S cluster; Region: FeS; pfam04060 767817011115 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 767817011116 phosphoenolpyruvate synthase; Validated; Region: PRK06241 767817011117 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 767817011118 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 767817011119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767817011120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767817011121 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 767817011122 substrate binding site [chemical binding]; other site 767817011123 multimerization interface [polypeptide binding]; other site 767817011124 ATP binding site [chemical binding]; other site 767817011125 Methyltransferase domain; Region: Methyltransf_31; pfam13847 767817011126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817011127 S-adenosylmethionine binding site [chemical binding]; other site 767817011128 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 767817011129 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 767817011130 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 767817011131 putative dimer interface [polypeptide binding]; other site 767817011132 active site pocket [active] 767817011133 putative cataytic base [active] 767817011134 cobalamin synthase; Reviewed; Region: cobS; PRK00235 767817011135 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 767817011136 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 767817011137 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 767817011138 putative metal binding residues [ion binding]; other site 767817011139 signature motif; other site 767817011140 dimer interface [polypeptide binding]; other site 767817011141 active site 767817011142 polyP binding site; other site 767817011143 substrate binding site [chemical binding]; other site 767817011144 acceptor-phosphate pocket; other site 767817011145 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817011146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817011147 active site 767817011148 phosphorylation site [posttranslational modification] 767817011149 intermolecular recognition site; other site 767817011150 dimerization interface [polypeptide binding]; other site 767817011151 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767817011152 DNA binding site [nucleotide binding] 767817011153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817011154 dimer interface [polypeptide binding]; other site 767817011155 phosphorylation site [posttranslational modification] 767817011156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817011157 ATP binding site [chemical binding]; other site 767817011158 Mg2+ binding site [ion binding]; other site 767817011159 G-X-G motif; other site 767817011160 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 767817011161 Activator of aromatic catabolism; Region: XylR_N; pfam06505 767817011162 V4R domain; Region: V4R; pfam02830 767817011163 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 767817011164 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 767817011165 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 767817011166 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 767817011167 putative ligand binding site [chemical binding]; other site 767817011168 putative NAD binding site [chemical binding]; other site 767817011169 catalytic site [active] 767817011170 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 767817011171 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 767817011172 AzlC protein; Region: AzlC; cl00570 767817011173 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 767817011174 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767817011175 putative DNA binding site [nucleotide binding]; other site 767817011176 putative Zn2+ binding site [ion binding]; other site 767817011177 AsnC family; Region: AsnC_trans_reg; pfam01037 767817011178 putative hydrolase; Validated; Region: PRK09248 767817011179 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 767817011180 active site 767817011181 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 767817011182 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 767817011183 putative active site [active] 767817011184 PhoH-like protein; Region: PhoH; cl17668 767817011185 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 767817011186 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 767817011187 dimer interface [polypeptide binding]; other site 767817011188 active site 767817011189 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767817011190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817011191 active site 767817011192 phosphorylation site [posttranslational modification] 767817011193 intermolecular recognition site; other site 767817011194 dimerization interface [polypeptide binding]; other site 767817011195 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 767817011196 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817011197 putative active site [active] 767817011198 heme pocket [chemical binding]; other site 767817011199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817011200 dimer interface [polypeptide binding]; other site 767817011201 phosphorylation site [posttranslational modification] 767817011202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817011203 ATP binding site [chemical binding]; other site 767817011204 Mg2+ binding site [ion binding]; other site 767817011205 G-X-G motif; other site 767817011206 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 767817011207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767817011208 dimer interface [polypeptide binding]; other site 767817011209 phosphorylation site [posttranslational modification] 767817011210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767817011211 ATP binding site [chemical binding]; other site 767817011212 Mg2+ binding site [ion binding]; other site 767817011213 G-X-G motif; other site 767817011214 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 767817011215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817011216 active site 767817011217 phosphorylation site [posttranslational modification] 767817011218 intermolecular recognition site; other site 767817011219 dimerization interface [polypeptide binding]; other site 767817011220 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817011221 non-specific DNA binding site [nucleotide binding]; other site 767817011222 salt bridge; other site 767817011223 sequence-specific DNA binding site [nucleotide binding]; other site 767817011224 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 767817011225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767817011226 Probable transposase; Region: OrfB_IS605; pfam01385 767817011227 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767817011228 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 767817011229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767817011230 Coenzyme A binding pocket [chemical binding]; other site 767817011231 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 767817011232 Zn binding site [ion binding]; other site 767817011233 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 767817011234 Transcriptional regulators [Transcription]; Region: GntR; COG1802 767817011235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767817011236 DNA-binding site [nucleotide binding]; DNA binding site 767817011237 FCD domain; Region: FCD; pfam07729 767817011238 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817011239 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 767817011240 SmpB-tmRNA interface; other site 767817011241 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 767817011242 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 767817011243 CoenzymeA binding site [chemical binding]; other site 767817011244 subunit interaction site [polypeptide binding]; other site 767817011245 PHB binding site; other site 767817011246 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 767817011247 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 767817011248 Preprotein translocase SecG subunit; Region: SecG; pfam03840 767817011249 enolase; Provisional; Region: eno; PRK00077 767817011250 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 767817011251 dimer interface [polypeptide binding]; other site 767817011252 metal binding site [ion binding]; metal-binding site 767817011253 substrate binding pocket [chemical binding]; other site 767817011254 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 767817011255 phosphoglyceromutase; Provisional; Region: PRK05434 767817011256 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 767817011257 triosephosphate isomerase; Provisional; Region: PRK14565 767817011258 substrate binding site [chemical binding]; other site 767817011259 dimer interface [polypeptide binding]; other site 767817011260 catalytic triad [active] 767817011261 Phosphoglycerate kinase; Region: PGK; pfam00162 767817011262 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 767817011263 substrate binding site [chemical binding]; other site 767817011264 hinge regions; other site 767817011265 ADP binding site [chemical binding]; other site 767817011266 catalytic site [active] 767817011267 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 767817011268 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 767817011269 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 767817011270 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 767817011271 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 767817011272 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 767817011273 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 767817011274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 767817011275 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 767817011276 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 767817011277 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 767817011278 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 767817011279 Ligand Binding Site [chemical binding]; other site 767817011280 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 767817011281 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 767817011282 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767817011283 catalytic residue [active] 767817011284 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 767817011285 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 767817011286 putative substrate binding pocket [chemical binding]; other site 767817011287 dimer interface [polypeptide binding]; other site 767817011288 phosphate binding site [ion binding]; other site 767817011289 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 767817011290 shikimate kinase; Reviewed; Region: aroK; PRK00131 767817011291 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 767817011292 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 767817011293 active site 767817011294 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 767817011295 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 767817011296 active site 767817011297 dimer interface [polypeptide binding]; other site 767817011298 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 767817011299 dimer interface [polypeptide binding]; other site 767817011300 active site 767817011301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767817011302 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767817011303 active site 767817011304 motif I; other site 767817011305 motif II; other site 767817011306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767817011307 motif II; other site 767817011308 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 767817011309 Coenzyme A transferase; Region: CoA_trans; smart00882 767817011310 Coenzyme A transferase; Region: CoA_trans; cl17247 767817011311 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 767817011312 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 767817011313 GIY-YIG motif/motif A; other site 767817011314 active site 767817011315 catalytic site [active] 767817011316 putative DNA binding site [nucleotide binding]; other site 767817011317 metal binding site [ion binding]; metal-binding site 767817011318 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 767817011319 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767817011320 MANEC domain; Region: MANEC; cl06508 767817011321 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055 767817011322 DnaA box-binding interface [nucleotide binding]; other site 767817011323 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 767817011324 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 767817011325 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 767817011326 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 767817011327 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 767817011328 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 767817011329 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 767817011330 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 767817011331 putative active site [active] 767817011332 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 767817011333 excinuclease ABC subunit B; Provisional; Region: PRK05298 767817011334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817011335 ATP binding site [chemical binding]; other site 767817011336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817011337 nucleotide binding region [chemical binding]; other site 767817011338 ATP-binding site [chemical binding]; other site 767817011339 Ultra-violet resistance protein B; Region: UvrB; pfam12344 767817011340 UvrB/uvrC motif; Region: UVR; pfam02151 767817011341 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 767817011342 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 767817011343 trimerization site [polypeptide binding]; other site 767817011344 active site 767817011345 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 767817011346 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 767817011347 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 767817011348 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 767817011349 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 767817011350 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 767817011351 ligand binding site [chemical binding]; other site 767817011352 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 767817011353 Fe-S cluster binding site [ion binding]; other site 767817011354 active site 767817011355 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 767817011356 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 767817011357 putative active site [active] 767817011358 Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133 767817011359 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 767817011360 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 767817011361 C-terminal peptidase (prc); Region: prc; TIGR00225 767817011362 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 767817011363 protein binding site [polypeptide binding]; other site 767817011364 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 767817011365 Catalytic dyad [active] 767817011366 CHD5-like protein; Region: CHD5; pfam04420 767817011367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 767817011368 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 767817011369 Peptidase family M23; Region: Peptidase_M23; pfam01551 767817011370 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 767817011371 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 767817011372 FtsX-like permease family; Region: FtsX; pfam02687 767817011373 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 767817011374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817011375 Walker A/P-loop; other site 767817011376 ATP binding site [chemical binding]; other site 767817011377 Q-loop/lid; other site 767817011378 ABC transporter signature motif; other site 767817011379 Walker B; other site 767817011380 D-loop; other site 767817011381 H-loop/switch region; other site 767817011382 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 767817011383 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 767817011384 PYR/PP interface [polypeptide binding]; other site 767817011385 dimer interface [polypeptide binding]; other site 767817011386 TPP binding site [chemical binding]; other site 767817011387 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767817011388 transketolase; Reviewed; Region: PRK05899 767817011389 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 767817011390 TPP-binding site [chemical binding]; other site 767817011391 dimer interface [polypeptide binding]; other site 767817011392 Uncharacterized conserved protein [Function unknown]; Region: COG1284 767817011393 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767817011394 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767817011395 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 767817011396 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 767817011397 iron binding site [ion binding]; other site 767817011398 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 767817011399 diiron binding motif [ion binding]; other site 767817011400 peptide chain release factor 2; Validated; Region: prfB; PRK00578 767817011401 This domain is found in peptide chain release factors; Region: PCRF; smart00937 767817011402 RF-1 domain; Region: RF-1; pfam00472 767817011403 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 767817011404 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767817011405 ATP binding site [chemical binding]; other site 767817011406 putative Mg++ binding site [ion binding]; other site 767817011407 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 767817011408 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 767817011409 30S subunit binding site; other site 767817011410 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 767817011411 DNA-binding site [nucleotide binding]; DNA binding site 767817011412 RNA-binding motif; other site 767817011413 comF family protein; Region: comF; TIGR00201 767817011414 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767817011415 active site 767817011416 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 767817011417 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 767817011418 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 767817011419 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 767817011420 metal binding site [ion binding]; metal-binding site 767817011421 active site 767817011422 I-site; other site 767817011423 S-adenosylmethionine synthetase; Validated; Region: PRK05250 767817011424 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 767817011425 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 767817011426 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 767817011427 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 767817011428 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 767817011429 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 767817011430 inhibitor-cofactor binding pocket; inhibition site 767817011431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817011432 catalytic residue [active] 767817011433 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 767817011434 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 767817011435 active site 767817011436 substrate binding site [chemical binding]; other site 767817011437 metal binding site [ion binding]; metal-binding site 767817011438 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 767817011439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767817011440 NAD(P) binding site [chemical binding]; other site 767817011441 active site 767817011442 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 767817011443 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 767817011444 active site 767817011445 tetramer interface; other site 767817011446 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 767817011447 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 767817011448 Mg++ binding site [ion binding]; other site 767817011449 putative catalytic motif [active] 767817011450 substrate binding site [chemical binding]; other site 767817011451 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 767817011452 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 767817011453 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 767817011454 Transcriptional regulator [Transcription]; Region: LytR; COG1316 767817011455 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 767817011456 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 767817011457 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817011458 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 767817011459 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767817011460 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817011461 S-layer homology domain; Region: SLH; pfam00395 767817011462 S-layer homology domain; Region: SLH; pfam00395 767817011463 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817011464 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817011465 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 767817011466 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817011467 active site 767817011468 DNA binding site [nucleotide binding] 767817011469 Int/Topo IB signature motif; other site 767817011470 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817011471 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 767817011472 active site 767817011473 DNA binding site [nucleotide binding] 767817011474 Int/Topo IB signature motif; other site 767817011475 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817011476 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 767817011477 active site 767817011478 DNA binding site [nucleotide binding] 767817011479 Int/Topo IB signature motif; other site 767817011480 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 767817011481 putative transposase; Provisional; Region: PRK09857 767817011482 Helix-turn-helix domain; Region: HTH_17; cl17695 767817011483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767817011484 AAA domain; Region: AAA_23; pfam13476 767817011485 Walker A/P-loop; other site 767817011486 ATP binding site [chemical binding]; other site 767817011487 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767817011488 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 767817011489 DNA binding residues [nucleotide binding] 767817011490 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 767817011491 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767817011492 nucleotide binding region [chemical binding]; other site 767817011493 ATP-binding site [chemical binding]; other site 767817011494 VRR-NUC domain; Region: VRR_NUC; pfam08774 767817011495 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 767817011496 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 767817011497 AAA domain; Region: AAA_24; pfam13479 767817011498 Protein of unknown function (DUF669); Region: DUF669; pfam05037 767817011499 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 767817011500 active site 767817011501 metal-binding site 767817011502 Prophage antirepressor [Transcription]; Region: COG3617 767817011503 BRO family, N-terminal domain; Region: Bro-N; smart01040 767817011504 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 767817011505 D5 N terminal like; Region: D5_N; smart00885 767817011506 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 767817011507 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 767817011508 GcrA cell cycle regulator; Region: GcrA; cl11564 767817011509 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 767817011510 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 767817011511 active site 767817011512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 767817011513 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 767817011514 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 767817011515 ParB-like nuclease domain; Region: ParB; smart00470 767817011516 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 767817011517 DNA methylase; Region: N6_N4_Mtase; pfam01555 767817011518 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 767817011519 ParB-like nuclease domain; Region: ParB; smart00470 767817011520 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 767817011521 DNA methylase; Region: N6_N4_Mtase; pfam01555 767817011522 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 767817011523 Phage terminase, small subunit; Region: Terminase_4; pfam05119 767817011524 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 767817011525 RelB antitoxin; Region: RelB; cl01171 767817011526 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 767817011527 Phage-related protein [Function unknown]; Region: COG4695 767817011528 Phage portal protein; Region: Phage_portal; pfam04860 767817011529 Clp protease; Region: CLP_protease; pfam00574 767817011530 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 767817011531 oligomer interface [polypeptide binding]; other site 767817011532 active site residues [active] 767817011533 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 767817011534 Phage capsid family; Region: Phage_capsid; pfam05065 767817011535 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 767817011536 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 767817011537 putative active site [active] 767817011538 putative NTP binding site [chemical binding]; other site 767817011539 putative nucleic acid binding site [nucleotide binding]; other site 767817011540 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 767817011541 oligomerization interface [polypeptide binding]; other site 767817011542 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 767817011543 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 767817011544 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 767817011545 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 767817011546 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 767817011547 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 767817011548 Phage tail protein; Region: Sipho_tail; cl17486 767817011549 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 767817011550 Trp docking motif [polypeptide binding]; other site 767817011551 active site 767817011552 Holin family; Region: Phage_holin_4; pfam05105 767817011553 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 767817011554 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 767817011555 active site 767817011556 metal binding site [ion binding]; metal-binding site 767817011557 Sporulation related domain; Region: SPOR; pfam05036 767817011558 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 767817011559 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817011560 active site 767817011561 DNA binding site [nucleotide binding] 767817011562 Int/Topo IB signature motif; other site 767817011563 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 767817011564 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 767817011565 Bacterial Ig-like domain; Region: Big_5; pfam13205 767817011566 Uncharacterized conserved protein [Function unknown]; Region: COG5464 767817011567 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 767817011568 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 767817011569 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 767817011570 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 767817011571 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817011572 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767817011573 DNA binding residues [nucleotide binding] 767817011574 hypothetical protein; Provisional; Region: PRK09956 767817011575 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 767817011576 Clostripain family; Region: Peptidase_C11; pfam03415 767817011577 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 767817011578 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 767817011579 Bacterial Ig-like domain; Region: Big_5; pfam13205 767817011580 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 767817011581 substrate binding site [chemical binding]; other site 767817011582 Transposase domain (DUF772); Region: DUF772; pfam05598 767817011583 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767817011584 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 767817011585 active site 767817011586 catalytic triad [active] 767817011587 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 767817011588 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817011589 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817011590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817011591 S-adenosylmethionine binding site [chemical binding]; other site 767817011592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 767817011593 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 767817011594 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 767817011595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767817011596 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 767817011597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767817011598 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 767817011599 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 767817011600 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 767817011601 AAA domain; Region: AAA_22; pfam13401 767817011602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817011603 Walker A motif; other site 767817011604 ATP binding site [chemical binding]; other site 767817011605 Walker B motif; other site 767817011606 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 767817011607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817011608 Walker A motif; other site 767817011609 ATP binding site [chemical binding]; other site 767817011610 Walker B motif; other site 767817011611 arginine finger; other site 767817011612 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 767817011613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767817011614 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767817011615 Helix-turn-helix domain; Region: HTH_38; pfam13936 767817011616 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767817011617 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 767817011618 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 767817011619 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 767817011620 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 767817011621 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 767817011622 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767817011623 active site 767817011624 DNA binding site [nucleotide binding] 767817011625 Int/Topo IB signature motif; other site 767817011626 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 767817011627 amidase catalytic site [active] 767817011628 Zn binding residues [ion binding]; other site 767817011629 substrate binding site [chemical binding]; other site 767817011630 Holin family; Region: Phage_holin_4; pfam05105 767817011631 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 767817011632 active site 767817011633 Trp docking motif [polypeptide binding]; other site 767817011634 Phage tail protein; Region: Sipho_tail; cl17486 767817011635 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 767817011636 Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340 767817011637 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 767817011638 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 767817011639 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 767817011640 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 767817011641 oligomerization interface [polypeptide binding]; other site 767817011642 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 767817011643 Phage capsid family; Region: Phage_capsid; pfam05065 767817011644 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 767817011645 oligomer interface [polypeptide binding]; other site 767817011646 active site residues [active] 767817011647 Phage-related protein [Function unknown]; Region: COG4695 767817011648 Phage portal protein; Region: Phage_portal; pfam04860 767817011649 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 767817011650 RelB antitoxin; Region: RelB; cl01171 767817011651 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 767817011652 Phage terminase, small subunit; Region: Terminase_4; pfam05119 767817011653 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 767817011654 putative active site pocket [active] 767817011655 dimerization interface [polypeptide binding]; other site 767817011656 putative catalytic residue [active] 767817011657 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 767817011658 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 767817011659 ParB-like nuclease domain; Region: ParB; smart00470 767817011660 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 767817011661 DNA methylase; Region: N6_N4_Mtase; pfam01555 767817011662 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 767817011663 ParB-like nuclease domain; Region: ParB; smart00470 767817011664 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 767817011665 DNA methylase; Region: N6_N4_Mtase; pfam01555 767817011666 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 767817011667 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 767817011668 active site 767817011669 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 767817011670 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 767817011671 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 767817011672 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767817011673 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 767817011674 ATP binding site [chemical binding]; other site 767817011675 putative Mg++ binding site [ion binding]; other site 767817011676 VRR-NUC domain; Region: VRR_NUC; pfam08774 767817011677 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 767817011678 D5 N terminal like; Region: D5_N; pfam08706 767817011679 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 767817011680 AntA/AntB antirepressor; Region: AntA; pfam08346 767817011681 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 767817011682 active site 767817011683 DNA binding site [nucleotide binding] 767817011684 catalytic site [active] 767817011685 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 767817011686 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 767817011687 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 767817011688 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 767817011689 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 767817011690 DNA binding residues [nucleotide binding] 767817011691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817011692 non-specific DNA binding site [nucleotide binding]; other site 767817011693 salt bridge; other site 767817011694 sequence-specific DNA binding site [nucleotide binding]; other site 767817011695 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 767817011696 non-specific DNA binding site [nucleotide binding]; other site 767817011697 salt bridge; other site 767817011698 sequence-specific DNA binding site [nucleotide binding]; other site 767817011699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 767817011700 Integrase core domain; Region: rve; pfam00665 767817011701 Integrase core domain; Region: rve_3; pfam13683 767817011702 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 767817011703 toxin interface [polypeptide binding]; other site 767817011704 Zn binding site [ion binding]; other site 767817011705 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 767817011706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 767817011707 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767817011708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767817011709 non-specific DNA binding site [nucleotide binding]; other site 767817011710 salt bridge; other site 767817011711 sequence-specific DNA binding site [nucleotide binding]; other site 767817011712 Domain of unknown function (DUF955); Region: DUF955; cl01076 767817011713 DNA topoisomerase I; Validated; Region: PRK05582 767817011714 Bacterial Ig-like domain; Region: Big_5; pfam13205 767817011715 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 767817011716 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 767817011717 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767817011718 active site 767817011719 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 767817011720 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 767817011721 Walker A/P-loop; other site 767817011722 ATP binding site [chemical binding]; other site 767817011723 Q-loop/lid; other site 767817011724 ABC transporter signature motif; other site 767817011725 Walker B; other site 767817011726 D-loop; other site 767817011727 H-loop/switch region; other site 767817011728 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 767817011729 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 767817011730 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817011731 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767817011732 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 767817011733 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767817011734 active site 767817011735 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767817011736 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817011737 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767817011738 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767817011739 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817011740 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767817011741 active site 767817011742 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 767817011743 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 767817011744 Bacterial sugar transferase; Region: Bac_transf; pfam02397 767817011745 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817011746 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 767817011747 putative ADP-binding pocket [chemical binding]; other site 767817011748 O-Antigen ligase; Region: Wzy_C; pfam04932 767817011749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767817011750 TPR motif; other site 767817011751 Tetratricopeptide repeat; Region: TPR_16; pfam13432 767817011752 binding surface 767817011753 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 767817011754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767817011755 putative substrate translocation pore; other site 767817011756 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 767817011757 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 767817011758 HlyD family secretion protein; Region: HlyD_3; pfam13437 767817011759 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 767817011760 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 767817011761 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 767817011762 HlyD family secretion protein; Region: HlyD_3; pfam13437 767817011763 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767817011764 MarR family; Region: MarR; pfam01047 767817011765 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 767817011766 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 767817011767 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817011768 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 767817011769 Outer membrane efflux protein; Region: OEP; pfam02321 767817011770 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 767817011771 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817011772 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 767817011773 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767817011774 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767817011775 DNA binding residues [nucleotide binding] 767817011776 Putative zinc-finger; Region: zf-HC2; pfam13490 767817011777 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 767817011778 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 767817011779 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 767817011780 active site 767817011781 catalytic triad [active] 767817011782 S-layer homology domain; Region: SLH; pfam00395 767817011783 S-layer homology domain; Region: SLH; pfam00395 767817011784 S-layer homology domain; Region: SLH; pfam00395 767817011785 rod shape-determining protein Mbl; Provisional; Region: PRK13928 767817011786 MreB and similar proteins; Region: MreB_like; cd10225 767817011787 nucleotide binding site [chemical binding]; other site 767817011788 Mg binding site [ion binding]; other site 767817011789 putative protofilament interaction site [polypeptide binding]; other site 767817011790 RodZ interaction site [polypeptide binding]; other site 767817011791 Stage III sporulation protein D; Region: SpoIIID; pfam12116 767817011792 Stage II sporulation protein; Region: SpoIID; pfam08486 767817011793 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 767817011794 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 767817011795 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 767817011796 hinge; other site 767817011797 active site 767817011798 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 767817011799 gamma subunit interface [polypeptide binding]; other site 767817011800 epsilon subunit interface [polypeptide binding]; other site 767817011801 LBP interface [polypeptide binding]; other site 767817011802 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 767817011803 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 767817011804 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 767817011805 alpha subunit interaction interface [polypeptide binding]; other site 767817011806 Walker A motif; other site 767817011807 ATP binding site [chemical binding]; other site 767817011808 Walker B motif; other site 767817011809 inhibitor binding site; inhibition site 767817011810 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 767817011811 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 767817011812 core domain interface [polypeptide binding]; other site 767817011813 delta subunit interface [polypeptide binding]; other site 767817011814 epsilon subunit interface [polypeptide binding]; other site 767817011815 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 767817011816 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 767817011817 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 767817011818 beta subunit interaction interface [polypeptide binding]; other site 767817011819 Walker A motif; other site 767817011820 ATP binding site [chemical binding]; other site 767817011821 Walker B motif; other site 767817011822 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 767817011823 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 767817011824 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 767817011825 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 767817011826 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 767817011827 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 767817011828 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 767817011829 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 767817011830 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 767817011831 PAS domain; Region: PAS; smart00091 767817011832 putative active site [active] 767817011833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 767817011834 putative active site [active] 767817011835 heme pocket [chemical binding]; other site 767817011836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817011837 Walker A motif; other site 767817011838 ATP binding site [chemical binding]; other site 767817011839 Walker B motif; other site 767817011840 arginine finger; other site 767817011841 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817011842 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 767817011843 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 767817011844 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 767817011845 NAD(P) binding site [chemical binding]; other site 767817011846 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 767817011847 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 767817011848 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 767817011849 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 767817011850 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 767817011851 inhibitor-cofactor binding pocket; inhibition site 767817011852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817011853 catalytic residue [active] 767817011854 Ubiquitin-like proteins; Region: UBQ; cl00155 767817011855 charged pocket; other site 767817011856 hydrophobic patch; other site 767817011857 amino acid transporter; Region: 2A0306; TIGR00909 767817011858 Coenzyme A transferase; Region: CoA_trans; cl17247 767817011859 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 767817011860 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 767817011861 Transcriptional regulator [Transcription]; Region: IclR; COG1414 767817011862 Bacterial transcriptional regulator; Region: IclR; pfam01614 767817011863 FOG: CBS domain [General function prediction only]; Region: COG0517 767817011864 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 767817011865 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 767817011866 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817011867 putative active site [active] 767817011868 heme pocket [chemical binding]; other site 767817011869 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817011870 putative active site [active] 767817011871 heme pocket [chemical binding]; other site 767817011872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817011873 Walker A motif; other site 767817011874 ATP binding site [chemical binding]; other site 767817011875 Walker B motif; other site 767817011876 arginine finger; other site 767817011877 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 767817011878 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 767817011879 carboxyltransferase (CT) interaction site; other site 767817011880 biotinylation site [posttranslational modification]; other site 767817011881 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 767817011882 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 767817011883 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 767817011884 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767817011885 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 767817011886 active site 767817011887 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 767817011888 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 767817011889 active site 767817011890 homodimer interface [polypeptide binding]; other site 767817011891 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 767817011892 homodimer interface [polypeptide binding]; other site 767817011893 metal binding site [ion binding]; metal-binding site 767817011894 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 767817011895 catalytic motif [active] 767817011896 Zn binding site [ion binding]; other site 767817011897 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 767817011898 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 767817011899 dimer interface [polypeptide binding]; other site 767817011900 active site 767817011901 glycine-pyridoxal phosphate binding site [chemical binding]; other site 767817011902 folate binding site [chemical binding]; other site 767817011903 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 767817011904 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 767817011905 Low molecular weight phosphatase family; Region: LMWPc; cd00115 767817011906 active site 767817011907 Predicted membrane protein [Function unknown]; Region: COG1971 767817011908 Domain of unknown function DUF; Region: DUF204; pfam02659 767817011909 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 767817011910 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 767817011911 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 767817011912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817011913 S-adenosylmethionine binding site [chemical binding]; other site 767817011914 peptide chain release factor 1; Validated; Region: prfA; PRK00591 767817011915 This domain is found in peptide chain release factors; Region: PCRF; smart00937 767817011916 RF-1 domain; Region: RF-1; pfam00472 767817011917 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 767817011918 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 767817011919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817011920 Radical SAM superfamily; Region: Radical_SAM; pfam04055 767817011921 FeS/SAM binding site; other site 767817011922 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 767817011923 active site 767817011924 NTP binding site [chemical binding]; other site 767817011925 metal binding triad [ion binding]; metal-binding site 767817011926 antibiotic binding site [chemical binding]; other site 767817011927 Protein of unknown function DUF86; Region: DUF86; pfam01934 767817011928 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 767817011929 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817011930 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817011931 Peptidase family M23; Region: Peptidase_M23; pfam01551 767817011932 transcription termination factor Rho; Provisional; Region: rho; PRK09376 767817011933 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 767817011934 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 767817011935 RNA binding site [nucleotide binding]; other site 767817011936 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 767817011937 multimer interface [polypeptide binding]; other site 767817011938 Walker A motif; other site 767817011939 ATP binding site [chemical binding]; other site 767817011940 Walker B motif; other site 767817011941 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 767817011942 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 767817011943 active site 767817011944 intersubunit interactions; other site 767817011945 catalytic residue [active] 767817011946 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 767817011947 intersubunit interface [polypeptide binding]; other site 767817011948 active site 767817011949 zinc binding site [ion binding]; other site 767817011950 Na+ binding site [ion binding]; other site 767817011951 Response regulator receiver domain; Region: Response_reg; pfam00072 767817011952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767817011953 active site 767817011954 phosphorylation site [posttranslational modification] 767817011955 intermolecular recognition site; other site 767817011956 dimerization interface [polypeptide binding]; other site 767817011957 Yip1 domain; Region: Yip1; pfam04893 767817011958 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 767817011959 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 767817011960 tandem repeat interface [polypeptide binding]; other site 767817011961 oligomer interface [polypeptide binding]; other site 767817011962 active site residues [active] 767817011963 CTP synthetase; Validated; Region: pyrG; PRK05380 767817011964 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 767817011965 Catalytic site [active] 767817011966 active site 767817011967 UTP binding site [chemical binding]; other site 767817011968 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 767817011969 active site 767817011970 putative oxyanion hole; other site 767817011971 catalytic triad [active] 767817011972 XapX domain; Region: XapX; TIGR03510 767817011973 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 767817011974 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 767817011975 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 767817011976 active site 767817011977 HIGH motif; other site 767817011978 KMSK motif region; other site 767817011979 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 767817011980 tRNA binding surface [nucleotide binding]; other site 767817011981 anticodon binding site; other site 767817011982 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 767817011983 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 767817011984 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 767817011985 dimer interface [polypeptide binding]; other site 767817011986 PYR/PP interface [polypeptide binding]; other site 767817011987 TPP binding site [chemical binding]; other site 767817011988 substrate binding site [chemical binding]; other site 767817011989 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 767817011990 TPP-binding site; other site 767817011991 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 767817011992 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 767817011993 Na binding site [ion binding]; other site 767817011994 hypothetical protein; Validated; Region: PRK07682 767817011995 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767817011996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817011997 homodimer interface [polypeptide binding]; other site 767817011998 catalytic residue [active] 767817011999 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 767817012000 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 767817012001 AsnC family; Region: AsnC_trans_reg; pfam01037 767817012002 germination protein YpeB; Region: spore_YpeB; TIGR02889 767817012003 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 767817012004 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 767817012005 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 767817012006 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 767817012007 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 767817012008 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 767817012009 catalytic triad [active] 767817012010 DsrC like protein; Region: DsrC; pfam04358 767817012011 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 767817012012 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767817012013 Cysteine-rich domain; Region: CCG; pfam02754 767817012014 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 767817012015 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 767817012016 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 767817012017 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 767817012018 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 767817012019 Walker A motif; other site 767817012020 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 767817012021 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 767817012022 switch II; other site 767817012023 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 767817012024 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 767817012025 switch II; other site 767817012026 Uncharacterized conserved protein [Function unknown]; Region: COG1433 767817012027 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 767817012028 TPR repeat; Region: TPR_11; pfam13414 767817012029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767817012030 binding surface 767817012031 TPR motif; other site 767817012032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767817012033 binding surface 767817012034 TPR motif; other site 767817012035 TPR repeat; Region: TPR_11; pfam13414 767817012036 Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679 767817012037 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 767817012038 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 767817012039 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 767817012040 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 767817012041 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 767817012042 HflX GTPase family; Region: HflX; cd01878 767817012043 G1 box; other site 767817012044 GTP/Mg2+ binding site [chemical binding]; other site 767817012045 Switch I region; other site 767817012046 G2 box; other site 767817012047 G3 box; other site 767817012048 Switch II region; other site 767817012049 G4 box; other site 767817012050 G5 box; other site 767817012051 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 767817012052 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767817012053 active site 767817012054 HIGH motif; other site 767817012055 nucleotide binding site [chemical binding]; other site 767817012056 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 767817012057 KMSKS motif; other site 767817012058 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 767817012059 isocitrate dehydrogenase; Validated; Region: PRK08299 767817012060 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 767817012061 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 767817012062 catalytic loop [active] 767817012063 iron binding site [ion binding]; other site 767817012064 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 767817012065 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 767817012066 4Fe-4S binding domain; Region: Fer4; pfam00037 767817012067 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 767817012068 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 767817012069 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 767817012070 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 767817012071 putative dimer interface [polypeptide binding]; other site 767817012072 [2Fe-2S] cluster binding site [ion binding]; other site 767817012073 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767817012074 PAS domain; Region: PAS_9; pfam13426 767817012075 putative active site [active] 767817012076 heme pocket [chemical binding]; other site 767817012077 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 767817012078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817012079 Walker A motif; other site 767817012080 ATP binding site [chemical binding]; other site 767817012081 Walker B motif; other site 767817012082 arginine finger; other site 767817012083 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 767817012084 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 767817012085 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 767817012086 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 767817012087 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767817012088 putative acyltransferase; Provisional; Region: PRK05790 767817012089 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 767817012090 dimer interface [polypeptide binding]; other site 767817012091 active site 767817012092 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767817012093 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 767817012094 active site 767817012095 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 767817012096 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 767817012097 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 767817012098 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 767817012099 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 767817012100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 767817012101 SIR2-like domain; Region: SIR2_2; pfam13289 767817012102 AAA domain; Region: AAA_31; pfam13614 767817012103 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767817012104 P-loop; other site 767817012105 Magnesium ion binding site [ion binding]; other site 767817012106 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767817012107 Magnesium ion binding site [ion binding]; other site 767817012108 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 767817012109 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 767817012110 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 767817012111 substrate binding site [chemical binding]; other site 767817012112 glutamase interaction surface [polypeptide binding]; other site 767817012113 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 767817012114 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 767817012115 hinge; other site 767817012116 active site 767817012117 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 767817012118 Tetratricopeptide repeat; Region: TPR_12; pfam13424 767817012119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767817012120 binding surface 767817012121 TPR motif; other site 767817012122 TPR repeat; Region: TPR_11; pfam13414 767817012123 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 767817012124 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767817012125 G5 domain; Region: G5; pfam07501 767817012126 Peptidase family M23; Region: Peptidase_M23; pfam01551 767817012127 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 767817012128 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767817012129 FeS/SAM binding site; other site 767817012130 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 767817012131 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 767817012132 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 767817012133 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 767817012134 active site 767817012135 metal binding site [ion binding]; metal-binding site 767817012136 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 767817012137 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 767817012138 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767817012139 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 767817012140 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 767817012141 active site 767817012142 NTP binding site [chemical binding]; other site 767817012143 metal binding triad [ion binding]; metal-binding site 767817012144 antibiotic binding site [chemical binding]; other site 767817012145 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 767817012146 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767817012147 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 767817012148 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 767817012149 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 767817012150 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767817012151 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817012152 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 767817012153 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 767817012154 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 767817012155 NAD binding site [chemical binding]; other site 767817012156 homotetramer interface [polypeptide binding]; other site 767817012157 homodimer interface [polypeptide binding]; other site 767817012158 active site 767817012159 substrate binding site [chemical binding]; other site 767817012160 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817012161 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 767817012162 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767817012163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817012164 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 767817012165 O-Antigen ligase; Region: Wzy_C; pfam04932 767817012166 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767817012167 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 767817012168 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 767817012169 O-Antigen ligase; Region: Wzy_C; pfam04932 767817012170 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817012171 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767817012172 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 767817012173 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 767817012174 Ligand binding site; other site 767817012175 Putative Catalytic site; other site 767817012176 DXD motif; other site 767817012177 Predicted membrane protein [Function unknown]; Region: COG2246 767817012178 GtrA-like protein; Region: GtrA; pfam04138 767817012179 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 767817012180 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 767817012181 NAD binding site [chemical binding]; other site 767817012182 putative substrate binding site 2 [chemical binding]; other site 767817012183 putative substrate binding site 1 [chemical binding]; other site 767817012184 active site 767817012185 Bacterial sugar transferase; Region: Bac_transf; pfam02397 767817012186 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 767817012187 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 767817012188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767817012189 NAD(P) binding site [chemical binding]; other site 767817012190 active site 767817012191 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 767817012192 Bacterial sugar transferase; Region: Bac_transf; pfam02397 767817012193 FemAB family; Region: FemAB; pfam02388 767817012194 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 767817012195 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 767817012196 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 767817012197 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 767817012198 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 767817012199 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 767817012200 O-Antigen ligase; Region: Wzy_C; pfam04932 767817012201 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 767817012202 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817012203 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817012204 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 767817012205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 767817012206 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 767817012207 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 767817012208 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 767817012209 NAD(P) binding site [chemical binding]; other site 767817012210 homodimer interface [polypeptide binding]; other site 767817012211 substrate binding site [chemical binding]; other site 767817012212 active site 767817012213 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 767817012214 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767817012215 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 767817012216 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 767817012217 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 767817012218 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767817012219 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767817012220 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 767817012221 active site 767817012222 cosubstrate binding site; other site 767817012223 substrate binding site [chemical binding]; other site 767817012224 catalytic site [active] 767817012225 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 767817012226 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 767817012227 inhibitor-cofactor binding pocket; inhibition site 767817012228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767817012229 catalytic residue [active] 767817012230 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 767817012231 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 767817012232 GDP-binding site [chemical binding]; other site 767817012233 ACT binding site; other site 767817012234 IMP binding site; other site 767817012235 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 767817012236 L-aspartate oxidase; Provisional; Region: PRK06175 767817012237 replicative DNA helicase; Region: DnaB; TIGR00665 767817012238 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 767817012239 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 767817012240 Walker A motif; other site 767817012241 ATP binding site [chemical binding]; other site 767817012242 Walker B motif; other site 767817012243 DNA binding loops [nucleotide binding] 767817012244 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 767817012245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767817012246 Walker A motif; other site 767817012247 ATP binding site [chemical binding]; other site 767817012248 Walker B motif; other site 767817012249 arginine finger; other site 767817012250 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 767817012251 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 767817012252 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 767817012253 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 767817012254 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 767817012255 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 767817012256 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 767817012257 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 767817012258 dimer interface [polypeptide binding]; other site 767817012259 ssDNA binding site [nucleotide binding]; other site 767817012260 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767817012261 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 767817012262 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 767817012263 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 767817012264 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 767817012265 oligomer interface [polypeptide binding]; other site 767817012266 putative active site [active] 767817012267 metal binding site [ion binding]; metal-binding site 767817012268 Uncharacterized membrane protein [Function unknown]; Region: COG3949 767817012269 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 767817012270 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 767817012271 ParB-like nuclease domain; Region: ParBc; pfam02195 767817012272 KorB domain; Region: KorB; pfam08535 767817012273 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 767817012274 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 767817012275 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767817012276 Magnesium ion binding site [ion binding]; other site 767817012277 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 767817012278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767817012279 S-adenosylmethionine binding site [chemical binding]; other site 767817012280 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 767817012281 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 767817012282 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 767817012283 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 767817012284 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 767817012285 trmE is a tRNA modification GTPase; Region: trmE; cd04164 767817012286 G1 box; other site 767817012287 GTP/Mg2+ binding site [chemical binding]; other site 767817012288 Switch I region; other site 767817012289 G2 box; other site 767817012290 Switch II region; other site 767817012291 G3 box; other site 767817012292 G4 box; other site 767817012293 G5 box; other site 767817012294 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 767817012295 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 767817012296 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 767817012297 G-X-X-G motif; other site 767817012298 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 767817012299 RxxxH motif; other site 767817012300 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 767817012301 Haemolytic domain; Region: Haemolytic; pfam01809 767817012302 ribonuclease P; Reviewed; Region: rnpA; PRK00499