-- dump date   	20140619_063810
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
760568000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
760568000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
760568000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568000004	Walker A motif; other site
760568000005	ATP binding site [chemical binding]; other site
760568000006	Walker B motif; other site
760568000007	arginine finger; other site
760568000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
760568000009	DnaA box-binding interface [nucleotide binding]; other site
760568000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
760568000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
760568000012	putative DNA binding surface [nucleotide binding]; other site
760568000013	dimer interface [polypeptide binding]; other site
760568000014	beta-clamp/clamp loader binding surface; other site
760568000015	beta-clamp/translesion DNA polymerase binding surface; other site
760568000016	recombination protein F; Reviewed; Region: recF; PRK00064
760568000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568000018	Walker A/P-loop; other site
760568000019	ATP binding site [chemical binding]; other site
760568000020	Q-loop/lid; other site
760568000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568000022	Q-loop/lid; other site
760568000023	ABC transporter signature motif; other site
760568000024	Walker B; other site
760568000025	D-loop; other site
760568000026	H-loop/switch region; other site
760568000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
760568000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568000029	Mg2+ binding site [ion binding]; other site
760568000030	G-X-G motif; other site
760568000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
760568000032	anchoring element; other site
760568000033	dimer interface [polypeptide binding]; other site
760568000034	ATP binding site [chemical binding]; other site
760568000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
760568000036	active site
760568000037	putative metal-binding site [ion binding]; other site
760568000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
760568000039	DNA gyrase subunit A; Validated; Region: PRK05560
760568000040	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
760568000041	CAP-like domain; other site
760568000042	active site
760568000043	primary dimer interface [polypeptide binding]; other site
760568000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
760568000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
760568000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
760568000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
760568000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
760568000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
760568000050	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
760568000051	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
760568000052	active site
760568000053	multimer interface [polypeptide binding]; other site
760568000054	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
760568000055	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152
760568000056	predicted active site [active]
760568000057	catalytic triad [active]
760568000058	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
760568000059	homodimer interface [polypeptide binding]; other site
760568000060	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568000061	catalytic residue [active]
760568000062	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
760568000063	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
760568000064	ligand binding site [chemical binding]; other site
760568000065	NAD binding site [chemical binding]; other site
760568000066	dimerization interface [polypeptide binding]; other site
760568000067	catalytic site [active]
760568000068	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
760568000069	putative L-serine binding site [chemical binding]; other site
760568000070	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
760568000071	catalytic core [active]
760568000072	seryl-tRNA synthetase; Provisional; Region: PRK05431
760568000073	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
760568000074	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
760568000075	dimer interface [polypeptide binding]; other site
760568000076	active site
760568000077	motif 1; other site
760568000078	motif 2; other site
760568000079	motif 3; other site
760568000080	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
760568000081	oligomeric interface; other site
760568000082	putative active site [active]
760568000083	homodimer interface [polypeptide binding]; other site
760568000084	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
760568000085	DNA binding residues [nucleotide binding]
760568000086	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
760568000087	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
760568000088	catalytic residues [active]
760568000089	catalytic nucleophile [active]
760568000090	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
760568000091	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
760568000092	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568000093	FeS/SAM binding site; other site
760568000094	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
760568000095	nucleoside/Zn binding site; other site
760568000096	dimer interface [polypeptide binding]; other site
760568000097	catalytic motif [active]
760568000098	S-layer homology domain; Region: SLH; pfam00395
760568000099	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
760568000100	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
760568000101	active site 1 [active]
760568000102	dimer interface [polypeptide binding]; other site
760568000103	hexamer interface [polypeptide binding]; other site
760568000104	active site 2 [active]
760568000105	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568000106	Zn2+ binding site [ion binding]; other site
760568000107	Mg2+ binding site [ion binding]; other site
760568000108	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
760568000109	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568000110	Walker A motif; other site
760568000111	ATP binding site [chemical binding]; other site
760568000112	Walker B motif; other site
760568000113	arginine finger; other site
760568000114	hypothetical protein; Validated; Region: PRK00153
760568000115	recombination protein RecR; Reviewed; Region: recR; PRK00076
760568000116	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
760568000117	helix-hairpin-helix signature motif; other site
760568000118	RecR protein; Region: RecR; pfam02132
760568000119	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
760568000120	putative active site [active]
760568000121	putative metal-binding site [ion binding]; other site
760568000122	tetramer interface [polypeptide binding]; other site
760568000123	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
760568000124	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
760568000125	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
760568000126	dimer interface [polypeptide binding]; other site
760568000127	PYR/PP interface [polypeptide binding]; other site
760568000128	TPP binding site [chemical binding]; other site
760568000129	substrate binding site [chemical binding]; other site
760568000130	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
760568000131	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
760568000132	TPP-binding site [chemical binding]; other site
760568000133	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
760568000134	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
760568000135	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568000136	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
760568000137	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
760568000138	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
760568000139	catalytic residue [active]
760568000140	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
760568000141	thymidylate kinase; Validated; Region: tmk; PRK00698
760568000142	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
760568000143	TMP-binding site; other site
760568000144	ATP-binding site [chemical binding]; other site
760568000145	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
760568000146	DNA polymerase III subunit delta'; Validated; Region: PRK08485
760568000147	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
760568000148	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
760568000149	Protein of unknown function (DUF972); Region: DUF972; pfam06156
760568000150	Predicted methyltransferases [General function prediction only]; Region: COG0313
760568000151	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
760568000152	putative SAM binding site [chemical binding]; other site
760568000153	putative homodimer interface [polypeptide binding]; other site
760568000154	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
760568000155	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
760568000156	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
760568000157	active site
760568000158	HIGH motif; other site
760568000159	KMSKS motif; other site
760568000160	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
760568000161	tRNA binding surface [nucleotide binding]; other site
760568000162	anticodon binding site; other site
760568000163	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
760568000164	active site
760568000165	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
760568000166	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
760568000167	homodimer interface [polypeptide binding]; other site
760568000168	Walker A motif; other site
760568000169	ATP binding site [chemical binding]; other site
760568000170	hydroxycobalamin binding site [chemical binding]; other site
760568000171	Walker B motif; other site
760568000172	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
760568000173	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
760568000174	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568000175	non-specific DNA binding site [nucleotide binding]; other site
760568000176	salt bridge; other site
760568000177	sequence-specific DNA binding site [nucleotide binding]; other site
760568000178	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568000179	non-specific DNA binding site [nucleotide binding]; other site
760568000180	salt bridge; other site
760568000181	sequence-specific DNA binding site [nucleotide binding]; other site
760568000182	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
760568000183	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568000184	non-specific DNA binding site [nucleotide binding]; other site
760568000185	salt bridge; other site
760568000186	sequence-specific DNA binding site [nucleotide binding]; other site
760568000187	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
760568000188	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
760568000189	B12 binding site [chemical binding]; other site
760568000190	cobalt ligand [ion binding]; other site
760568000191	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
760568000192	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
760568000193	B12 binding site [chemical binding]; other site
760568000194	cobalt ligand [ion binding]; other site
760568000195	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
760568000196	MtaA_CmuA_like family. MtaA/CmuA, also MtsA, or methyltransferase 2 (MT2) MT2-A and MT2-M isozymes, are methylcobamide:Coenzyme M methyltransferases, which play a role in metabolic pathways of methane formation from various substrates, such as methylated...; Region: Mta_CmuA_like; cd03307
760568000197	Methanol-cobalamin methyltransferase B subunit; Region: MtaB; pfam12176
760568000198	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
760568000199	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
760568000200	B12 binding site [chemical binding]; other site
760568000201	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
760568000202	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
760568000203	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
760568000204	methylamine methyltransferase corrinoid protein reductive activase; Region: Rama_corrin_act; TIGR04270
760568000205	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568000206	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
760568000207	Uroporphyrinogen decarboxylase (URO-D); Region: URO-D; pfam01208
760568000208	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
760568000209	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
760568000210	B12 binding site [chemical binding]; other site
760568000211	cobalt ligand [ion binding]; other site
760568000212	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
760568000213	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
760568000214	catalytic loop [active]
760568000215	iron binding site [ion binding]; other site
760568000216	tetrahydromethanopterin S-methyltransferase subunit H; Provisional; Region: PRK00979
760568000217	Tetrahydromethanopterin S-methyltransferase, subunit H [Coenzyme metabolism]; Region: MtrH; cl15798
760568000218	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
760568000219	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
760568000220	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
760568000221	epoxyqueuosine reductase; Region: TIGR00276
760568000222	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
760568000223	4Fe-4S binding domain; Region: Fer4; cl02805
760568000224	DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502
760568000225	Domain of unknown function (DUF348); Region: DUF348; pfam03990
760568000226	Domain of unknown function (DUF348); Region: DUF348; pfam03990
760568000227	G5 domain; Region: G5; pfam07501
760568000228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
760568000229	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
760568000230	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
760568000231	Protein of unknown function (DUF458); Region: DUF458; pfam04308
760568000232	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
760568000233	Rubredoxin; Region: Rubredoxin; pfam00301
760568000234	iron binding site [ion binding]; other site
760568000235	Rubrerythrin [Energy production and conversion]; Region: COG1592
760568000236	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
760568000237	binuclear metal center [ion binding]; other site
760568000238	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
760568000239	iron binding site [ion binding]; other site
760568000240	YabG peptidase U57; Region: Peptidase_U57; pfam05582
760568000241	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
760568000242	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
760568000243	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
760568000244	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
760568000245	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
760568000246	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
760568000247	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
760568000248	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
760568000249	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
760568000250	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
760568000251	Protein of unknown function, DUF606; Region: DUF606; pfam04657
760568000252	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
760568000253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
760568000254	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
760568000255	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
760568000256	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
760568000257	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
760568000258	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
760568000259	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
760568000260	putative active site [active]
760568000261	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
760568000262	oligomeric interface; other site
760568000263	putative active site [active]
760568000264	homodimer interface [polypeptide binding]; other site
760568000265	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
760568000266	Protein of unknown function (DUF499); Region: DUF499; pfam04465
760568000267	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
760568000268	Methyltransferase domain; Region: Methyltransf_26; pfam13659
760568000269	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
760568000270	DNA methylase; Region: N6_N4_Mtase; cl17433
760568000271	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
760568000272	putative active site [active]
760568000273	catalytic site [active]
760568000274	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
760568000275	ATP binding site [chemical binding]; other site
760568000276	putative Mg++ binding site [ion binding]; other site
760568000277	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
760568000278	nucleotide binding region [chemical binding]; other site
760568000279	ATP-binding site [chemical binding]; other site
760568000280	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
760568000281	proposed catalytic triad [active]
760568000282	active site nucleophile [active]
760568000283	Protein of unknown function DUF86; Region: DUF86; cl01031
760568000284	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568000285	active site
760568000286	NTP binding site [chemical binding]; other site
760568000287	metal binding triad [ion binding]; metal-binding site
760568000288	antibiotic binding site [chemical binding]; other site
760568000289	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
760568000290	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
760568000291	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
760568000292	HlyD family secretion protein; Region: HlyD_3; pfam13437
760568000293	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
760568000294	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
760568000295	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
760568000296	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
760568000297	dimer interface [polypeptide binding]; other site
760568000298	conserved gate region; other site
760568000299	putative PBP binding loops; other site
760568000300	ABC-ATPase subunit interface; other site
760568000301	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
760568000302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
760568000303	dimer interface [polypeptide binding]; other site
760568000304	conserved gate region; other site
760568000305	putative PBP binding loops; other site
760568000306	ABC-ATPase subunit interface; other site
760568000307	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
760568000308	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
760568000309	Walker A/P-loop; other site
760568000310	ATP binding site [chemical binding]; other site
760568000311	Q-loop/lid; other site
760568000312	ABC transporter signature motif; other site
760568000313	Walker B; other site
760568000314	D-loop; other site
760568000315	H-loop/switch region; other site
760568000316	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
760568000317	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
760568000318	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
760568000319	Walker A/P-loop; other site
760568000320	ATP binding site [chemical binding]; other site
760568000321	Q-loop/lid; other site
760568000322	ABC transporter signature motif; other site
760568000323	Walker B; other site
760568000324	D-loop; other site
760568000325	H-loop/switch region; other site
760568000326	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
760568000327	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
760568000328	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
760568000329	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
760568000330	Coenzyme A binding pocket [chemical binding]; other site
760568000331	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG3366
760568000332	Nucleoside recognition; Region: Gate; pfam07670
760568000333	Nucleoside recognition; Region: Gate; pfam07670
760568000334	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
760568000335	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
760568000336	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
760568000337	intersubunit interface [polypeptide binding]; other site
760568000338	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
760568000339	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
760568000340	ABC-ATPase subunit  interface; other site
760568000341	dimer interface [polypeptide binding]; other site
760568000342	putative PBP binding regions; other site
760568000343	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
760568000344	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
760568000345	Walker A/P-loop; other site
760568000346	ATP binding site [chemical binding]; other site
760568000347	Q-loop/lid; other site
760568000348	ABC transporter signature motif; other site
760568000349	Walker B; other site
760568000350	D-loop; other site
760568000351	H-loop/switch region; other site
760568000352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568000353	S-adenosylmethionine binding site [chemical binding]; other site
760568000354	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568000355	S-adenosylmethionine binding site [chemical binding]; other site
760568000356	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
760568000357	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568000358	S-adenosylmethionine binding site [chemical binding]; other site
760568000359	Trm112p-like protein; Region: Trm112p; cl01066
760568000360	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
760568000361	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
760568000362	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
760568000363	substrate binding site [chemical binding]; other site
760568000364	Methyltransferase domain; Region: Methyltransf_31; pfam13847
760568000365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568000366	S-adenosylmethionine binding site [chemical binding]; other site
760568000367	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
760568000368	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
760568000369	substrate binding site [chemical binding]; other site
760568000370	Methyltransferase domain; Region: Methyltransf_31; pfam13847
760568000371	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568000372	S-adenosylmethionine binding site [chemical binding]; other site
760568000373	Predicted membrane protein [Function unknown]; Region: COG2510
760568000374	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
760568000375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568000376	S-adenosylmethionine binding site [chemical binding]; other site
760568000377	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
760568000378	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
760568000379	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
760568000380	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
760568000381	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
760568000382	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568000383	active site
760568000384	NTP binding site [chemical binding]; other site
760568000385	metal binding triad [ion binding]; metal-binding site
760568000386	antibiotic binding site [chemical binding]; other site
760568000387	HEAT repeats; Region: HEAT_2; pfam13646
760568000388	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
760568000389	TPR motif; other site
760568000390	TPR repeat; Region: TPR_11; pfam13414
760568000391	binding surface
760568000392	SEC-C motif; Region: SEC-C; pfam02810
760568000393	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
760568000394	homodimer interaction site [polypeptide binding]; other site
760568000395	cofactor binding site; other site
760568000396	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
760568000397	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
760568000398	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
760568000399	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
760568000400	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
760568000401	putative metal binding site [ion binding]; other site
760568000402	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
760568000403	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
760568000404	ABC-ATPase subunit  interface; other site
760568000405	dimer interface [polypeptide binding]; other site
760568000406	putative PBP binding regions; other site
760568000407	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
760568000408	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
760568000409	Walker A/P-loop; other site
760568000410	ATP binding site [chemical binding]; other site
760568000411	Q-loop/lid; other site
760568000412	ABC transporter signature motif; other site
760568000413	Walker B; other site
760568000414	D-loop; other site
760568000415	H-loop/switch region; other site
760568000416	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_21; cd08520
760568000417	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
760568000418	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
760568000419	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
760568000420	dimer interface [polypeptide binding]; other site
760568000421	conserved gate region; other site
760568000422	putative PBP binding loops; other site
760568000423	ABC-ATPase subunit interface; other site
760568000424	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
760568000425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
760568000426	dimer interface [polypeptide binding]; other site
760568000427	conserved gate region; other site
760568000428	putative PBP binding loops; other site
760568000429	ABC-ATPase subunit interface; other site
760568000430	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
760568000431	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
760568000432	Walker A/P-loop; other site
760568000433	ATP binding site [chemical binding]; other site
760568000434	Q-loop/lid; other site
760568000435	ABC transporter signature motif; other site
760568000436	Walker B; other site
760568000437	D-loop; other site
760568000438	H-loop/switch region; other site
760568000439	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
760568000440	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
760568000441	Walker A/P-loop; other site
760568000442	ATP binding site [chemical binding]; other site
760568000443	Q-loop/lid; other site
760568000444	ABC transporter signature motif; other site
760568000445	Walker B; other site
760568000446	D-loop; other site
760568000447	H-loop/switch region; other site
760568000448	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
760568000449	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
760568000450	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
760568000451	putative active site [active]
760568000452	cyanophycin synthetase; Provisional; Region: PRK14016
760568000453	ATP-grasp domain; Region: ATP-grasp_4; cl17255
760568000454	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
760568000455	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
760568000456	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
760568000457	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
760568000458	Transcriptional regulators [Transcription]; Region: GntR; COG1802
760568000459	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
760568000460	DNA-binding site [nucleotide binding]; DNA binding site
760568000461	FCD domain; Region: FCD; pfam07729
760568000462	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
760568000463	active site
760568000464	threonine dehydratase; Provisional; Region: PRK08198
760568000465	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
760568000466	tetramer interface [polypeptide binding]; other site
760568000467	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568000468	catalytic residue [active]
760568000469	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
760568000470	regulatory protein SpoVG; Reviewed; Region: PRK13259
760568000471	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
760568000472	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
760568000473	Substrate binding site; other site
760568000474	Mg++ binding site; other site
760568000475	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
760568000476	active site
760568000477	substrate binding site [chemical binding]; other site
760568000478	CoA binding site [chemical binding]; other site
760568000479	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
760568000480	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
760568000481	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
760568000482	active site
760568000483	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
760568000484	PRC-barrel domain; Region: PRC; pfam05239
760568000485	PRC-barrel domain; Region: PRC; pfam05239
760568000486	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
760568000487	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
760568000488	5S rRNA interface [nucleotide binding]; other site
760568000489	CTC domain interface [polypeptide binding]; other site
760568000490	L16 interface [polypeptide binding]; other site
760568000491	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
760568000492	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568000493	putative active site [active]
760568000494	heme pocket [chemical binding]; other site
760568000495	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568000496	Walker A motif; other site
760568000497	ATP binding site [chemical binding]; other site
760568000498	Walker B motif; other site
760568000499	arginine finger; other site
760568000500	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
760568000501	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
760568000502	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
760568000503	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
760568000504	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
760568000505	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
760568000506	active site
760568000507	NAD binding site [chemical binding]; other site
760568000508	metal binding site [ion binding]; metal-binding site
760568000509	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
760568000510	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
760568000511	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
760568000512	DctM-like transporters; Region: DctM; pfam06808
760568000513	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
760568000514	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
760568000515	Malic enzyme, N-terminal domain; Region: malic; pfam00390
760568000516	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
760568000517	putative NAD(P) binding site [chemical binding]; other site
760568000518	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
760568000519	Malic enzyme, N-terminal domain; Region: malic; pfam00390
760568000520	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
760568000521	putative NAD(P) binding site [chemical binding]; other site
760568000522	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
760568000523	putative active site [active]
760568000524	catalytic residue [active]
760568000525	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
760568000526	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
760568000527	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
760568000528	ATP binding site [chemical binding]; other site
760568000529	putative Mg++ binding site [ion binding]; other site
760568000530	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
760568000531	nucleotide binding region [chemical binding]; other site
760568000532	ATP-binding site [chemical binding]; other site
760568000533	TRCF domain; Region: TRCF; pfam03461
760568000534	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
760568000535	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
760568000536	acyl-activating enzyme (AAE) consensus motif; other site
760568000537	putative AMP binding site [chemical binding]; other site
760568000538	putative active site [active]
760568000539	putative CoA binding site [chemical binding]; other site
760568000540	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
760568000541	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
760568000542	transmembrane helices; other site
760568000543	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
760568000544	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
760568000545	ligand binding site [chemical binding]; other site
760568000546	NAD binding site [chemical binding]; other site
760568000547	dimerization interface [polypeptide binding]; other site
760568000548	catalytic site [active]
760568000549	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
760568000550	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
760568000551	Cysteine-rich domain; Region: CCG; pfam02754
760568000552	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
760568000553	4Fe-4S binding domain; Region: Fer4; pfam00037
760568000554	NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493
760568000555	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
760568000556	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
760568000557	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
760568000558	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
760568000559	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568000560	4Fe-4S binding domain; Region: Fer4; pfam00037
760568000561	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
760568000562	4Fe-4S binding domain; Region: Fer4; pfam00037
760568000563	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
760568000564	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568000565	4Fe-4S binding domain; Region: Fer4; pfam00037
760568000566	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831
760568000567	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
760568000568	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568000569	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
760568000570	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
760568000571	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
760568000572	Cysteine-rich domain; Region: CCG; pfam02754
760568000573	Cysteine-rich domain; Region: CCG; pfam02754
760568000574	DNA polymerase IV; Reviewed; Region: PRK03103
760568000575	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
760568000576	active site
760568000577	DNA binding site [nucleotide binding]
760568000578	PAS domain; Region: PAS; smart00091
760568000579	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
760568000580	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568000581	active site
760568000582	phosphorylation site [posttranslational modification]
760568000583	intermolecular recognition site; other site
760568000584	dimerization interface [polypeptide binding]; other site
760568000585	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
760568000586	DNA binding residues [nucleotide binding]
760568000587	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568000588	PAS domain; Region: PAS_9; pfam13426
760568000589	putative active site [active]
760568000590	heme pocket [chemical binding]; other site
760568000591	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
760568000592	Histidine kinase; Region: HisKA_3; pfam07730
760568000593	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568000594	ATP binding site [chemical binding]; other site
760568000595	Mg2+ binding site [ion binding]; other site
760568000596	G-X-G motif; other site
760568000597	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
760568000598	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
760568000599	stage V sporulation protein T; Region: spore_V_T; TIGR02851
760568000600	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
760568000601	GAF domain; Region: GAF; pfam01590
760568000602	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
760568000603	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
760568000604	putative SAM binding site [chemical binding]; other site
760568000605	putative homodimer interface [polypeptide binding]; other site
760568000606	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
760568000607	homodimer interface [polypeptide binding]; other site
760568000608	metal binding site [ion binding]; metal-binding site
760568000609	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
760568000610	homodimer interface [polypeptide binding]; other site
760568000611	active site
760568000612	putative chemical substrate binding site [chemical binding]; other site
760568000613	metal binding site [ion binding]; metal-binding site
760568000614	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
760568000615	IHF dimer interface [polypeptide binding]; other site
760568000616	IHF - DNA interface [nucleotide binding]; other site
760568000617	Stage II sporulation protein; Region: SpoIID; pfam08486
760568000618	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
760568000619	YabP family; Region: YabP; cl06766
760568000620	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801
760568000621	Septum formation initiator; Region: DivIC; pfam04977
760568000622	hypothetical protein; Provisional; Region: PRK08582
760568000623	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
760568000624	RNA binding site [nucleotide binding]; other site
760568000625	exopolyphosphatase; Region: exo_poly_only; TIGR03706
760568000626	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
760568000627	nucleotide binding site [chemical binding]; other site
760568000628	stage II sporulation protein E; Region: spore_II_E; TIGR02865
760568000629	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
760568000630	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
760568000631	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
760568000632	Ligand Binding Site [chemical binding]; other site
760568000633	TilS substrate C-terminal domain; Region: TilS_C; smart00977
760568000634	FtsH Extracellular; Region: FtsH_ext; pfam06480
760568000635	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
760568000636	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568000637	Walker A motif; other site
760568000638	ATP binding site [chemical binding]; other site
760568000639	Walker B motif; other site
760568000640	arginine finger; other site
760568000641	Peptidase family M41; Region: Peptidase_M41; pfam01434
760568000642	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
760568000643	active site
760568000644	multimer interface [polypeptide binding]; other site
760568000645	Predicted thioesterase [General function prediction only]; Region: COG5496
760568000646	Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759
760568000647	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
760568000648	Potassium binding sites [ion binding]; other site
760568000649	Cesium cation binding sites [ion binding]; other site
760568000650	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
760568000651	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
760568000652	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
760568000653	dihydropteroate synthase; Region: DHPS; TIGR01496
760568000654	substrate binding pocket [chemical binding]; other site
760568000655	dimer interface [polypeptide binding]; other site
760568000656	inhibitor binding site; inhibition site
760568000657	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
760568000658	homooctamer interface [polypeptide binding]; other site
760568000659	active site
760568000660	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
760568000661	catalytic center binding site [active]
760568000662	ATP binding site [chemical binding]; other site
760568000663	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568000664	active site
760568000665	NTP binding site [chemical binding]; other site
760568000666	metal binding triad [ion binding]; metal-binding site
760568000667	antibiotic binding site [chemical binding]; other site
760568000668	Protein of unknown function DUF86; Region: DUF86; pfam01934
760568000669	Archaeal ATPase; Region: Arch_ATPase; pfam01637
760568000670	AAA domain; Region: AAA_14; pfam13173
760568000671	Helix-turn-helix domain; Region: HTH_36; pfam13730
760568000672	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
760568000673	CoenzymeA binding site [chemical binding]; other site
760568000674	subunit interaction site [polypeptide binding]; other site
760568000675	PHB binding site; other site
760568000676	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
760568000677	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
760568000678	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
760568000679	ligand binding site [chemical binding]; other site
760568000680	flexible hinge region; other site
760568000681	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
760568000682	putative switch regulator; other site
760568000683	non-specific DNA interactions [nucleotide binding]; other site
760568000684	DNA binding site [nucleotide binding]
760568000685	sequence specific DNA binding site [nucleotide binding]; other site
760568000686	putative cAMP binding site [chemical binding]; other site
760568000687	MTH865-like family; Region: MTH865; cl01962
760568000688	PemK-like protein; Region: PemK; pfam02452
760568000689	Ferritin-like domain; Region: Ferritin; pfam00210
760568000690	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
760568000691	dinuclear metal binding motif [ion binding]; other site
760568000692	Uncharacterized conserved protein [Function unknown]; Region: COG1683
760568000693	TRAM domain; Region: TRAM; pfam01938
760568000694	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
760568000695	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568000696	S-adenosylmethionine binding site [chemical binding]; other site
760568000697	Staphylococcal nuclease homologues; Region: SNc; smart00318
760568000698	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
760568000699	Catalytic site; other site
760568000700	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
760568000701	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
760568000702	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
760568000703	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
760568000704	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
760568000705	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
760568000706	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
760568000707	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
760568000708	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
760568000709	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
760568000710	active site
760568000711	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
760568000712	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
760568000713	dimer interface [polypeptide binding]; other site
760568000714	active site
760568000715	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
760568000716	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
760568000717	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
760568000718	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
760568000719	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
760568000720	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
760568000721	substrate binding site [chemical binding]; other site
760568000722	oxyanion hole (OAH) forming residues; other site
760568000723	trimer interface [polypeptide binding]; other site
760568000724	LysE type translocator; Region: LysE; cl00565
760568000725	LysE type translocator; Region: LysE; cl00565
760568000726	hypothetical protein; Provisional; Region: PRK03881
760568000727	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
760568000728	AMMECR1; Region: AMMECR1; pfam01871
760568000729	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
760568000730	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568000731	FeS/SAM binding site; other site
760568000732	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
760568000733	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
760568000734	HflX GTPase family; Region: HflX; cd01878
760568000735	G1 box; other site
760568000736	GTP/Mg2+ binding site [chemical binding]; other site
760568000737	Switch I region; other site
760568000738	G2 box; other site
760568000739	G3 box; other site
760568000740	Switch II region; other site
760568000741	G4 box; other site
760568000742	G5 box; other site
760568000743	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
760568000744	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568000745	non-specific DNA binding site [nucleotide binding]; other site
760568000746	salt bridge; other site
760568000747	sequence-specific DNA binding site [nucleotide binding]; other site
760568000748	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
760568000749	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568000750	non-specific DNA binding site [nucleotide binding]; other site
760568000751	salt bridge; other site
760568000752	sequence-specific DNA binding site [nucleotide binding]; other site
760568000753	S-layer homology domain; Region: SLH; pfam00395
760568000754	S-layer homology domain; Region: SLH; pfam00395
760568000755	S-layer homology domain; Region: SLH; pfam00395
760568000756	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
760568000757	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
760568000758	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
760568000759	Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217
760568000760	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
760568000761	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
760568000762	Fn3 associated; Region: Fn3_assoc; pfam13287
760568000763	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
760568000764	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
760568000765	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
760568000766	Bacterial Ig-like domain; Region: Big_5; pfam13205
760568000767	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
760568000768	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
760568000769	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
760568000770	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
760568000771	Transposase [DNA replication, recombination, and repair]; Region: COG5421
760568000772	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
760568000773	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
760568000774	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
760568000775	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
760568000776	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
760568000777	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
760568000778	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
760568000779	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
760568000780	Dimerisation domain; Region: Dimerisation; pfam08100
760568000781	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568000782	S-adenosylmethionine binding site [chemical binding]; other site
760568000783	Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050
760568000784	B12 binding domain; Region: B12-binding; pfam02310
760568000785	B12 binding site [chemical binding]; other site
760568000786	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
760568000787	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568000788	FeS/SAM binding site; other site
760568000789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568000790	Major Facilitator Superfamily; Region: MFS_1; pfam07690
760568000791	putative substrate translocation pore; other site
760568000792	Predicted transcriptional regulators [Transcription]; Region: COG1695
760568000793	Transcriptional regulator PadR-like family; Region: PadR; cl17335
760568000794	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
760568000795	tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730
760568000796	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
760568000797	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
760568000798	metal-binding site [ion binding]
760568000799	Domain of unknown function (DUF2703); Region: DUF2703; pfam10865
760568000800	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
760568000801	arsenical-resistance protein; Region: acr3; TIGR00832
760568000802	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
760568000803	DGC domain; Region: DGC; pfam08859
760568000804	Predicted permease; Region: DUF318; cl17795
760568000805	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
760568000806	Sodium Bile acid symporter family; Region: SBF; cl17470
760568000807	Putative Fe-S cluster; Region: FeS; cl17515
760568000808	tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317
760568000809	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568000810	FeS/SAM binding site; other site
760568000811	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
760568000812	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
760568000813	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
760568000814	CPxP  motif; other site
760568000815	Predicted permease; Region: DUF318; cl17795
760568000816	Predicted permease; Region: DUF318; cl17795
760568000817	Predicted transcriptional regulators [Transcription]; Region: COG1695
760568000818	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
760568000819	putative Zn2+ binding site [ion binding]; other site
760568000820	putative DNA binding site [nucleotide binding]; other site
760568000821	hydroxylamine reductase; Provisional; Region: PRK12310
760568000822	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
760568000823	cubane metal cluster [ion binding]; other site
760568000824	hybrid metal cluster; other site
760568000825	SNF2 Helicase protein; Region: DUF3670; pfam12419
760568000826	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
760568000827	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
760568000828	ATP binding site [chemical binding]; other site
760568000829	putative Mg++ binding site [ion binding]; other site
760568000830	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
760568000831	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
760568000832	nucleotide binding region [chemical binding]; other site
760568000833	ATP-binding site [chemical binding]; other site
760568000834	Uncharacterized conserved protein [Function unknown]; Region: COG4279
760568000835	SWIM zinc finger; Region: SWIM; pfam04434
760568000836	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
760568000837	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
760568000838	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
760568000839	DNA binding residues [nucleotide binding]
760568000840	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
760568000841	catalytic residues [active]
760568000842	catalytic nucleophile [active]
760568000843	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
760568000844	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
760568000845	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
760568000846	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
760568000847	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
760568000848	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
760568000849	dimer interface [polypeptide binding]; other site
760568000850	acyl-activating enzyme (AAE) consensus motif; other site
760568000851	putative active site [active]
760568000852	AMP binding site [chemical binding]; other site
760568000853	putative CoA binding site [chemical binding]; other site
760568000854	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
760568000855	putative active site [active]
760568000856	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
760568000857	Low molecular weight phosphatase family; Region: LMWPc; cd00115
760568000858	active site
760568000859	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
760568000860	EamA-like transporter family; Region: EamA; pfam00892
760568000861	EamA-like transporter family; Region: EamA; pfam00892
760568000862	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
760568000863	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
760568000864	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
760568000865	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
760568000866	Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796
760568000867	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
760568000868	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
760568000869	Propionate catabolism activator; Region: PrpR_N; pfam06506
760568000870	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
760568000871	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568000872	putative active site [active]
760568000873	heme pocket [chemical binding]; other site
760568000874	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568000875	Walker A motif; other site
760568000876	ATP binding site [chemical binding]; other site
760568000877	Walker B motif; other site
760568000878	arginine finger; other site
760568000879	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
760568000880	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
760568000881	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
760568000882	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
760568000883	Ligand binding site [chemical binding]; other site
760568000884	Electron transfer flavoprotein domain; Region: ETF; pfam01012
760568000885	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
760568000886	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
760568000887	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
760568000888	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
760568000889	DctM-like transporters; Region: DctM; pfam06808
760568000890	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
760568000891	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
760568000892	active site
760568000893	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
760568000894	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
760568000895	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
760568000896	dimer interface [polypeptide binding]; other site
760568000897	active site
760568000898	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
760568000899	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
760568000900	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
760568000901	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
760568000902	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
760568000903	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
760568000904	putative acyltransferase; Provisional; Region: PRK05790
760568000905	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
760568000906	dimer interface [polypeptide binding]; other site
760568000907	active site
760568000908	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
760568000909	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
760568000910	substrate binding site [chemical binding]; other site
760568000911	oxyanion hole (OAH) forming residues; other site
760568000912	trimer interface [polypeptide binding]; other site
760568000913	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
760568000914	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
760568000915	active site
760568000916	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
760568000917	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
760568000918	active site
760568000919	hypothetical protein; Provisional; Region: PRK04262
760568000920	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
760568000921	dimer interface [polypeptide binding]; other site
760568000922	active site
760568000923	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
760568000924	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
760568000925	DUF35 OB-fold domain; Region: DUF35; pfam01796
760568000926	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
760568000927	active site
760568000928	catalytic site [active]
760568000929	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
760568000930	dimer interaction site [polypeptide binding]; other site
760568000931	substrate-binding tunnel; other site
760568000932	active site
760568000933	catalytic site [active]
760568000934	substrate binding site [chemical binding]; other site
760568000935	Uncharacterized conserved protein [Function unknown]; Region: COG2006
760568000936	Domain of unknown function (DUF362); Region: DUF362; pfam04015
760568000937	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
760568000938	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
760568000939	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
760568000940	heterotetramer interface [polypeptide binding]; other site
760568000941	active site pocket [active]
760568000942	cleavage site
760568000943	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
760568000944	feedback inhibition sensing region; other site
760568000945	homohexameric interface [polypeptide binding]; other site
760568000946	nucleotide binding site [chemical binding]; other site
760568000947	N-acetyl-L-glutamate binding site [chemical binding]; other site
760568000948	acetylornithine aminotransferase; Provisional; Region: PRK02627
760568000949	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
760568000950	inhibitor-cofactor binding pocket; inhibition site
760568000951	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568000952	catalytic residue [active]
760568000953	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
760568000954	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
760568000955	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
760568000956	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
760568000957	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
760568000958	ATP-grasp domain; Region: ATP-grasp_4; cl17255
760568000959	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
760568000960	substrate binding site [chemical binding]; other site
760568000961	ornithine carbamoyltransferase; Provisional; Region: PRK00779
760568000962	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
760568000963	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
760568000964	argininosuccinate synthase; Provisional; Region: PRK13820
760568000965	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
760568000966	ANP binding site [chemical binding]; other site
760568000967	Substrate Binding Site II [chemical binding]; other site
760568000968	Substrate Binding Site I [chemical binding]; other site
760568000969	Protein of unknown function (DUF433); Region: DUF433; pfam04255
760568000970	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
760568000971	FOG: CBS domain [General function prediction only]; Region: COG0517
760568000972	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc2; cd04599
760568000973	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568000974	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568000975	metal binding site [ion binding]; metal-binding site
760568000976	active site
760568000977	I-site; other site
760568000978	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
760568000979	Zn binding site [ion binding]; other site
760568000980	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
760568000981	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
760568000982	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
760568000983	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
760568000984	SCP-2 sterol transfer family; Region: SCP2; pfam02036
760568000985	putative transporter; Provisional; Region: PRK11021
760568000986	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
760568000987	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
760568000988	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
760568000989	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568000990	Bacterial SH3 domain; Region: SH3_3; pfam08239
760568000991	AMIN domain; Region: AMIN; pfam11741
760568000992	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
760568000993	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
760568000994	active site
760568000995	metal binding site [ion binding]; metal-binding site
760568000996	glutamate racemase; Provisional; Region: PRK00865
760568000997	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
760568000998	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
760568000999	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
760568001000	ribonuclease PH; Reviewed; Region: rph; PRK00173
760568001001	Ribonuclease PH; Region: RNase_PH_bact; cd11362
760568001002	hexamer interface [polypeptide binding]; other site
760568001003	active site
760568001004	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
760568001005	active site
760568001006	dimerization interface [polypeptide binding]; other site
760568001007	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
760568001008	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
760568001009	active site
760568001010	metal binding site [ion binding]; metal-binding site
760568001011	homotetramer interface [polypeptide binding]; other site
760568001012	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
760568001013	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
760568001014	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
760568001015	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
760568001016	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
760568001017	dimer interface [polypeptide binding]; other site
760568001018	phosphorylation site [posttranslational modification]
760568001019	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568001020	ATP binding site [chemical binding]; other site
760568001021	Mg2+ binding site [ion binding]; other site
760568001022	G-X-G motif; other site
760568001023	Response regulator receiver domain; Region: Response_reg; pfam00072
760568001024	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568001025	active site
760568001026	phosphorylation site [posttranslational modification]
760568001027	intermolecular recognition site; other site
760568001028	dimerization interface [polypeptide binding]; other site
760568001029	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
760568001030	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
760568001031	Ligand Binding Site [chemical binding]; other site
760568001032	TIGR00269 family protein; Region: TIGR00269
760568001033	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
760568001034	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
760568001035	active site
760568001036	dimerization interface [polypeptide binding]; other site
760568001037	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
760568001038	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
760568001039	DNA binding residues [nucleotide binding]
760568001040	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
760568001041	catalytic residues [active]
760568001042	catalytic nucleophile [active]
760568001043	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568001044	H+ Antiporter protein; Region: 2A0121; TIGR00900
760568001045	putative substrate translocation pore; other site
760568001046	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
760568001047	trigger factor; Provisional; Region: tig; PRK01490
760568001048	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
760568001049	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
760568001050	Clp protease; Region: CLP_protease; pfam00574
760568001051	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
760568001052	oligomer interface [polypeptide binding]; other site
760568001053	active site residues [active]
760568001054	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
760568001055	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
760568001056	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568001057	Walker A motif; other site
760568001058	ATP binding site [chemical binding]; other site
760568001059	Walker B motif; other site
760568001060	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
760568001061	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
760568001062	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568001063	Walker A motif; other site
760568001064	ATP binding site [chemical binding]; other site
760568001065	Walker B motif; other site
760568001066	arginine finger; other site
760568001067	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
760568001068	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
760568001069	Found in ATP-dependent protease La (LON); Region: LON; smart00464
760568001070	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568001071	Walker A motif; other site
760568001072	ATP binding site [chemical binding]; other site
760568001073	Walker B motif; other site
760568001074	arginine finger; other site
760568001075	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
760568001076	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
760568001077	G1 box; other site
760568001078	GTP/Mg2+ binding site [chemical binding]; other site
760568001079	Switch I region; other site
760568001080	G2 box; other site
760568001081	G3 box; other site
760568001082	Switch II region; other site
760568001083	G4 box; other site
760568001084	G5 box; other site
760568001085	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
760568001086	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
760568001087	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
760568001088	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
760568001089	HIGH motif; other site
760568001090	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
760568001091	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
760568001092	active site
760568001093	KMSKS motif; other site
760568001094	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
760568001095	tRNA binding surface [nucleotide binding]; other site
760568001096	anticodon binding site; other site
760568001097	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
760568001098	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
760568001099	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
760568001100	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
760568001101	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
760568001102	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
760568001103	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
760568001104	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
760568001105	Maf-like protein; Reviewed; Region: PRK00078
760568001106	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
760568001107	active site
760568001108	dimer interface [polypeptide binding]; other site
760568001109	hypothetical protein; Reviewed; Region: PRK00024
760568001110	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
760568001111	MPN+ (JAMM) motif; other site
760568001112	Zinc-binding site [ion binding]; other site
760568001113	rod shape-determining protein MreB; Provisional; Region: PRK13927
760568001114	MreB and similar proteins; Region: MreB_like; cd10225
760568001115	nucleotide binding site [chemical binding]; other site
760568001116	Mg binding site [ion binding]; other site
760568001117	putative protofilament interaction site [polypeptide binding]; other site
760568001118	RodZ interaction site [polypeptide binding]; other site
760568001119	rod shape-determining protein MreC; Provisional; Region: PRK13922
760568001120	rod shape-determining protein MreC; Region: MreC; pfam04085
760568001121	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
760568001122	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
760568001123	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
760568001124	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
760568001125	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
760568001126	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
760568001127	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
760568001128	Switch I; other site
760568001129	Switch II; other site
760568001130	Septum formation topological specificity factor MinE; Region: MinE; cl00538
760568001131	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
760568001132	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
760568001133	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
760568001134	Peptidase family M23; Region: Peptidase_M23; pfam01551
760568001135	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
760568001136	Peptidase family M50; Region: Peptidase_M50; pfam02163
760568001137	active site
760568001138	putative substrate binding region [chemical binding]; other site
760568001139	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
760568001140	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
760568001141	B12 binding site [chemical binding]; other site
760568001142	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568001143	FeS/SAM binding site; other site
760568001144	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
760568001145	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
760568001146	ribonuclease G; Provisional; Region: PRK11712
760568001147	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
760568001148	homodimer interface [polypeptide binding]; other site
760568001149	oligonucleotide binding site [chemical binding]; other site
760568001150	TRAM domain; Region: TRAM; cl01282
760568001151	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
760568001152	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
760568001153	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
760568001154	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
760568001155	GTPase CgtA; Reviewed; Region: obgE; PRK12297
760568001156	GTP1/OBG; Region: GTP1_OBG; pfam01018
760568001157	Obg GTPase; Region: Obg; cd01898
760568001158	G1 box; other site
760568001159	GTP/Mg2+ binding site [chemical binding]; other site
760568001160	Switch I region; other site
760568001161	G2 box; other site
760568001162	G3 box; other site
760568001163	Switch II region; other site
760568001164	G4 box; other site
760568001165	G5 box; other site
760568001166	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
760568001167	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568001168	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
760568001169	gamma-glutamyl kinase; Provisional; Region: PRK05429
760568001170	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
760568001171	nucleotide binding site [chemical binding]; other site
760568001172	homotetrameric interface [polypeptide binding]; other site
760568001173	putative phosphate binding site [ion binding]; other site
760568001174	putative allosteric binding site; other site
760568001175	PUA domain; Region: PUA; pfam01472
760568001176	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
760568001177	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
760568001178	putative catalytic cysteine [active]
760568001179	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
760568001180	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
760568001181	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
760568001182	putative dimerization interface [polypeptide binding]; other site
760568001183	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
760568001184	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
760568001185	active site
760568001186	(T/H)XGH motif; other site
760568001187	fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552
760568001188	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
760568001189	fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626
760568001190	L-aspartate oxidase; Provisional; Region: PRK06175
760568001191	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
760568001192	Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581
760568001193	Iron-sulfur protein interface; other site
760568001194	proximal heme binding site [chemical binding]; other site
760568001195	distal heme binding site [chemical binding]; other site
760568001196	dimer interface [polypeptide binding]; other site
760568001197	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
760568001198	Oligomerisation domain; Region: Oligomerisation; pfam02410
760568001199	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
760568001200	AMP-binding domain protein; Validated; Region: PRK08315
760568001201	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
760568001202	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
760568001203	acyl-activating enzyme (AAE) consensus motif; other site
760568001204	putative AMP binding site [chemical binding]; other site
760568001205	putative active site [active]
760568001206	putative CoA binding site [chemical binding]; other site
760568001207	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
760568001208	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
760568001209	HIGH motif; other site
760568001210	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
760568001211	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
760568001212	active site
760568001213	KMSKS motif; other site
760568001214	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
760568001215	tRNA binding surface [nucleotide binding]; other site
760568001216	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839
760568001217	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
760568001218	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
760568001219	DNA binding residues [nucleotide binding]
760568001220	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817
760568001221	CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766
760568001222	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679
760568001223	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
760568001224	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
760568001225	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748
760568001226	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
760568001227	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cd09682
760568001228	CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749
760568001229	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
760568001230	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
760568001231	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
760568001232	Family of unknown function (DUF694); Region: DUF694; pfam05107
760568001233	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
760568001234	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
760568001235	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
760568001236	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
760568001237	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
760568001238	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
760568001239	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
760568001240	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
760568001241	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
760568001242	putative active site [active]
760568001243	homotetrameric interface [polypeptide binding]; other site
760568001244	metal binding site [ion binding]; metal-binding site
760568001245	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
760568001246	MgtC family; Region: MgtC; pfam02308
760568001247	Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253
760568001248	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
760568001249	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
760568001250	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
760568001251	active site
760568001252	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
760568001253	BON domain; Region: BON; pfam04972
760568001254	Putative amidase domain; Region: Amidase_6; pfam12671
760568001255	Transcriptional regulator [Transcription]; Region: LytR; COG1316
760568001256	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
760568001257	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
760568001258	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
760568001259	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
760568001260	CoA binding domain; Region: CoA_binding_2; pfam13380
760568001261	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
760568001262	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
760568001263	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
760568001264	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
760568001265	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
760568001266	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
760568001267	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
760568001268	Dynamin family; Region: Dynamin_N; pfam00350
760568001269	G1 box; other site
760568001270	GTP/Mg2+ binding site [chemical binding]; other site
760568001271	G2 box; other site
760568001272	Switch I region; other site
760568001273	G3 box; other site
760568001274	Switch II region; other site
760568001275	G4 box; other site
760568001276	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
760568001277	G1 box; other site
760568001278	GTP/Mg2+ binding site [chemical binding]; other site
760568001279	G2 box; other site
760568001280	Switch I region; other site
760568001281	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
760568001282	G3 box; other site
760568001283	Switch II region; other site
760568001284	GTP/Mg2+ binding site [chemical binding]; other site
760568001285	G4 box; other site
760568001286	G5 box; other site
760568001287	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568001288	S-adenosylmethionine binding site [chemical binding]; other site
760568001289	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
760568001290	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
760568001291	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
760568001292	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
760568001293	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
760568001294	DNA binding residues [nucleotide binding]
760568001295	Putative zinc-finger; Region: zf-HC2; pfam13490
760568001296	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
760568001297	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
760568001298	Predicted amidohydrolase [General function prediction only]; Region: COG0388
760568001299	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
760568001300	putative active site [active]
760568001301	catalytic triad [active]
760568001302	dimer interface [polypeptide binding]; other site
760568001303	GTP-binding protein YchF; Reviewed; Region: PRK09601
760568001304	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
760568001305	G1 box; other site
760568001306	GTP/Mg2+ binding site [chemical binding]; other site
760568001307	G2 box; other site
760568001308	Switch I region; other site
760568001309	G3 box; other site
760568001310	Switch II region; other site
760568001311	G4 box; other site
760568001312	G5 box; other site
760568001313	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
760568001314	Radical SAM superfamily; Region: Radical_SAM; pfam04055
760568001315	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568001316	FeS/SAM binding site; other site
760568001317	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
760568001318	Coat F domain; Region: Coat_F; pfam07875
760568001319	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
760568001320	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
760568001321	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
760568001322	enoyl-CoA hydratase; Provisional; Region: PRK07657
760568001323	substrate binding site [chemical binding]; other site
760568001324	oxyanion hole (OAH) forming residues; other site
760568001325	trimer interface [polypeptide binding]; other site
760568001326	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
760568001327	active site
760568001328	catalytic residues [active]
760568001329	metal binding site [ion binding]; metal-binding site
760568001330	AAA domain; Region: AAA_28; pfam13521
760568001331	AAA domain; Region: AAA_17; pfam13207
760568001332	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
760568001333	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
760568001334	metal-binding site [ion binding]
760568001335	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
760568001336	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
760568001337	active site
760568001338	motif I; other site
760568001339	motif II; other site
760568001340	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
760568001341	dimerization interface [polypeptide binding]; other site
760568001342	putative DNA binding site [nucleotide binding]; other site
760568001343	putative Zn2+ binding site [ion binding]; other site
760568001344	RmuC family; Region: RmuC; pfam02646
760568001345	Amino acid permease; Region: AA_permease_2; pfam13520
760568001346	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
760568001347	putative active site [active]
760568001348	YdjC motif; other site
760568001349	Mg binding site [ion binding]; other site
760568001350	putative homodimer interface [polypeptide binding]; other site
760568001351	hypothetical protein; Provisional; Region: PRK06851
760568001352	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
760568001353	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
760568001354	putative active site [active]
760568001355	hypothetical protein; Provisional; Region: PRK06851
760568001356	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
760568001357	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
760568001358	catalytic residues [active]
760568001359	catalytic nucleophile [active]
760568001360	Recombinase; Region: Recombinase; pfam07508
760568001361	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
760568001362	Patatin phospholipase; Region: DUF3734; pfam12536
760568001363	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
760568001364	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
760568001365	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
760568001366	hypothetical protein; Provisional; Region: PRK06761
760568001367	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
760568001368	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568001369	active site
760568001370	phosphorylation site [posttranslational modification]
760568001371	intermolecular recognition site; other site
760568001372	dimerization interface [polypeptide binding]; other site
760568001373	ANTAR domain; Region: ANTAR; pfam03861
760568001374	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
760568001375	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
760568001376	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
760568001377	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
760568001378	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
760568001379	active site
760568001380	FMN binding site [chemical binding]; other site
760568001381	substrate binding site [chemical binding]; other site
760568001382	3Fe-4S cluster binding site [ion binding]; other site
760568001383	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
760568001384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568001385	active site
760568001386	phosphorylation site [posttranslational modification]
760568001387	intermolecular recognition site; other site
760568001388	dimerization interface [polypeptide binding]; other site
760568001389	ANTAR domain; Region: ANTAR; pfam03861
760568001390	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
760568001391	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
760568001392	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
760568001393	glutamine synthetase, type I; Region: GlnA; TIGR00653
760568001394	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
760568001395	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
760568001396	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
760568001397	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
760568001398	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
760568001399	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
760568001400	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
760568001401	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
760568001402	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
760568001403	putative active site [active]
760568001404	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568001405	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
760568001406	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
760568001407	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
760568001408	active site
760568001409	FMN binding site [chemical binding]; other site
760568001410	substrate binding site [chemical binding]; other site
760568001411	3Fe-4S cluster binding site [ion binding]; other site
760568001412	Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981
760568001413	putative subunit interface; other site
760568001414	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
760568001415	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
760568001416	putative valine binding site [chemical binding]; other site
760568001417	dimer interface [polypeptide binding]; other site
760568001418	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
760568001419	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
760568001420	PemK-like protein; Region: PemK; pfam02452
760568001421	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
760568001422	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
760568001423	catalytic triad [active]
760568001424	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
760568001425	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
760568001426	active site
760568001427	Response regulator receiver domain; Region: Response_reg; pfam00072
760568001428	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568001429	active site
760568001430	phosphorylation site [posttranslational modification]
760568001431	intermolecular recognition site; other site
760568001432	dimerization interface [polypeptide binding]; other site
760568001433	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
760568001434	thiamine phosphate binding site [chemical binding]; other site
760568001435	active site
760568001436	pyrophosphate binding site [ion binding]; other site
760568001437	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
760568001438	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
760568001439	thiamine monophosphate kinase; Provisional; Region: PRK05731
760568001440	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
760568001441	ATP binding site [chemical binding]; other site
760568001442	dimerization interface [polypeptide binding]; other site
760568001443	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
760568001444	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
760568001445	Glycoprotease family; Region: Peptidase_M22; pfam00814
760568001446	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
760568001447	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
760568001448	Coenzyme A binding pocket [chemical binding]; other site
760568001449	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
760568001450	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
760568001451	dimer interface [polypeptide binding]; other site
760568001452	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568001453	catalytic residue [active]
760568001454	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
760568001455	EamA-like transporter family; Region: EamA; pfam00892
760568001456	EamA-like transporter family; Region: EamA; pfam00892
760568001457	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
760568001458	DNA binding site [nucleotide binding]
760568001459	active site
760568001460	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
760568001461	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
760568001462	Mg2+ binding site [ion binding]; other site
760568001463	G-X-G motif; other site
760568001464	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
760568001465	anti sigma factor interaction site; other site
760568001466	regulatory phosphorylation site [posttranslational modification]; other site
760568001467	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
760568001468	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
760568001469	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
760568001470	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
760568001471	anti sigma factor interaction site; other site
760568001472	regulatory phosphorylation site [posttranslational modification]; other site
760568001473	Protein of unknown function (DUF342); Region: DUF342; pfam03961
760568001474	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
760568001475	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
760568001476	putative active site [active]
760568001477	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568001478	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
760568001479	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
760568001480	Nuclease-related domain; Region: NERD; pfam08378
760568001481	Catalytic domain of Protein Kinases; Region: PKc; cd00180
760568001482	active site
760568001483	ATP binding site [chemical binding]; other site
760568001484	substrate binding site [chemical binding]; other site
760568001485	activation loop (A-loop); other site
760568001486	hypothetical protein; Provisional; Region: PHA02988
760568001487	Catalytic domain of Protein Kinases; Region: PKc; cd00180
760568001488	active site
760568001489	ATP binding site [chemical binding]; other site
760568001490	substrate binding site [chemical binding]; other site
760568001491	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
760568001492	activation loop (A-loop); other site
760568001493	activation loop (A-loop); other site
760568001494	AAA-like domain; Region: AAA_10; pfam12846
760568001495	Domain of unknown function DUF87; Region: DUF87; pfam01935
760568001496	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
760568001497	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
760568001498	SIR2-like domain; Region: SIR2_2; pfam13289
760568001499	Domain of unknown function DUF87; Region: DUF87; pfam01935
760568001500	HerA helicase [Replication, recombination, and repair]; Region: COG0433
760568001501	Response regulator receiver domain; Region: Response_reg; pfam00072
760568001502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568001503	active site
760568001504	phosphorylation site [posttranslational modification]
760568001505	intermolecular recognition site; other site
760568001506	dimerization interface [polypeptide binding]; other site
760568001507	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
760568001508	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
760568001509	Ligand Binding Site [chemical binding]; other site
760568001510	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
760568001511	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
760568001512	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
760568001513	N-acetyl-D-glucosamine binding site [chemical binding]; other site
760568001514	catalytic residue [active]
760568001515	Transcriptional regulators [Transcription]; Region: GntR; COG1802
760568001516	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
760568001517	DNA-binding site [nucleotide binding]; DNA binding site
760568001518	FCD domain; Region: FCD; pfam07729
760568001519	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
760568001520	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
760568001521	active site pocket [active]
760568001522	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
760568001523	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
760568001524	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
760568001525	DctM-like transporters; Region: DctM; pfam06808
760568001526	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
760568001527	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
760568001528	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
760568001529	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
760568001530	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
760568001531	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
760568001532	MoaE interaction surface [polypeptide binding]; other site
760568001533	MoeB interaction surface [polypeptide binding]; other site
760568001534	thiocarboxylated glycine; other site
760568001535	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
760568001536	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
760568001537	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
760568001538	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
760568001539	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
760568001540	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
760568001541	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
760568001542	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
760568001543	DNA binding site [nucleotide binding]
760568001544	catalytic residue [active]
760568001545	H2TH interface [polypeptide binding]; other site
760568001546	putative catalytic residues [active]
760568001547	turnover-facilitating residue; other site
760568001548	intercalation triad [nucleotide binding]; other site
760568001549	8OG recognition residue [nucleotide binding]; other site
760568001550	putative reading head residues; other site
760568001551	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
760568001552	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
760568001553	DNA polymerase I; Provisional; Region: PRK05755
760568001554	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
760568001555	active site
760568001556	metal binding site 1 [ion binding]; metal-binding site
760568001557	putative 5' ssDNA interaction site; other site
760568001558	metal binding site 3; metal-binding site
760568001559	metal binding site 2 [ion binding]; metal-binding site
760568001560	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
760568001561	putative DNA binding site [nucleotide binding]; other site
760568001562	putative metal binding site [ion binding]; other site
760568001563	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
760568001564	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
760568001565	active site
760568001566	DNA binding site [nucleotide binding]
760568001567	catalytic site [active]
760568001568	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
760568001569	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
760568001570	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
760568001571	protein binding site [polypeptide binding]; other site
760568001572	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
760568001573	Catalytic dyad [active]
760568001574	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568001575	SEC-C motif; Region: SEC-C; pfam02810
760568001576	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
760568001577	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
760568001578	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
760568001579	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
760568001580	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
760568001581	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
760568001582	Sensory domain found in PocR; Region: PocR; pfam10114
760568001583	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
760568001584	GAF domain; Region: GAF; cl17456
760568001585	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
760568001586	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
760568001587	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
760568001588	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568001589	Zn2+ binding site [ion binding]; other site
760568001590	Mg2+ binding site [ion binding]; other site
760568001591	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
760568001592	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909
760568001593	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
760568001594	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
760568001595	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
760568001596	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
760568001597	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
760568001598	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
760568001599	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
760568001600	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
760568001601	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
760568001602	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
760568001603	Transcriptional regulator [Transcription]; Region: IclR; COG1414
760568001604	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
760568001605	putative DNA binding site [nucleotide binding]; other site
760568001606	putative Zn2+ binding site [ion binding]; other site
760568001607	Bacterial transcriptional regulator; Region: IclR; pfam01614
760568001608	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
760568001609	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
760568001610	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
760568001611	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08385
760568001612	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
760568001613	active site
760568001614	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
760568001615	acetaldehyde dehydrogenase; Validated; Region: PRK08300
760568001616	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
760568001617	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
760568001618	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
760568001619	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
760568001620	active site
760568001621	catalytic residues [active]
760568001622	metal binding site [ion binding]; metal-binding site
760568001623	DmpG-like communication domain; Region: DmpG_comm; pfam07836
760568001624	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
760568001625	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
760568001626	active site
760568001627	metal binding site [ion binding]; metal-binding site
760568001628	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
760568001629	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
760568001630	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
760568001631	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
760568001632	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
760568001633	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
760568001634	MoaE interaction surface [polypeptide binding]; other site
760568001635	MoeB interaction surface [polypeptide binding]; other site
760568001636	thiocarboxylated glycine; other site
760568001637	Probable molybdopterin binding domain; Region: MoCF_biosynth; pfam00994
760568001638	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
760568001639	MPT binding site; other site
760568001640	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
760568001641	NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179
760568001642	putative active site [active]
760568001643	metal binding site [ion binding]; metal-binding site
760568001644	Ubiquitin-like proteins; Region: UBQ; cl00155
760568001645	charged pocket; other site
760568001646	hydrophobic patch; other site
760568001647	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
760568001648	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
760568001649	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
760568001650	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
760568001651	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
760568001652	active site
760568001653	NAD binding site [chemical binding]; other site
760568001654	metal binding site [ion binding]; metal-binding site
760568001655	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
760568001656	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
760568001657	hypothetical protein; Provisional; Region: PRK04194
760568001658	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
760568001659	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
760568001660	dimerization interface [polypeptide binding]; other site
760568001661	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
760568001662	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
760568001663	dimer interface [polypeptide binding]; other site
760568001664	putative CheW interface [polypeptide binding]; other site
760568001665	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
760568001666	Uncharacterized membrane protein [Function unknown]; Region: COG3949
760568001667	YtxC-like family; Region: YtxC; pfam08812
760568001668	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
760568001669	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
760568001670	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
760568001671	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
760568001672	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
760568001673	active site
760568001674	dimer interface [polypeptide binding]; other site
760568001675	motif 1; other site
760568001676	motif 2; other site
760568001677	motif 3; other site
760568001678	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
760568001679	anticodon binding site; other site
760568001680	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
760568001681	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
760568001682	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
760568001683	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
760568001684	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
760568001685	23S rRNA binding site [nucleotide binding]; other site
760568001686	L21 binding site [polypeptide binding]; other site
760568001687	L13 binding site [polypeptide binding]; other site
760568001688	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
760568001689	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
760568001690	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
760568001691	TrkA-N domain; Region: TrkA_N; pfam02254
760568001692	TrkA-C domain; Region: TrkA_C; pfam02080
760568001693	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
760568001694	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
760568001695	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
760568001696	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
760568001697	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
760568001698	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
760568001699	dimer interface [polypeptide binding]; other site
760568001700	motif 1; other site
760568001701	active site
760568001702	motif 2; other site
760568001703	motif 3; other site
760568001704	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
760568001705	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
760568001706	putative tRNA-binding site [nucleotide binding]; other site
760568001707	B3/4 domain; Region: B3_4; pfam03483
760568001708	tRNA synthetase B5 domain; Region: B5; smart00874
760568001709	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
760568001710	dimer interface [polypeptide binding]; other site
760568001711	motif 1; other site
760568001712	motif 3; other site
760568001713	motif 2; other site
760568001714	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
760568001715	Cell division protein ZapA; Region: ZapA; pfam05164
760568001716	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
760568001717	hypothetical protein; Provisional; Region: PRK08609
760568001718	active site
760568001719	primer binding site [nucleotide binding]; other site
760568001720	NTP  binding site [chemical binding]; other site
760568001721	metal binding triad [ion binding]; metal-binding site
760568001722	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
760568001723	active site
760568001724	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
760568001725	active site
760568001726	DNA binding site [nucleotide binding]
760568001727	Short C-terminal domain; Region: SHOCT; pfam09851
760568001728	Uncharacterized conserved protein [Function unknown]; Region: COG0327
760568001729	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
760568001730	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
760568001731	Peptidase family U32; Region: Peptidase_U32; pfam01136
760568001732	Collagenase; Region: DUF3656; pfam12392
760568001733	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
760568001734	Peptidase family U32; Region: Peptidase_U32; pfam01136
760568001735	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
760568001736	MutS domain III; Region: MutS_III; pfam05192
760568001737	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
760568001738	Walker A/P-loop; other site
760568001739	ATP binding site [chemical binding]; other site
760568001740	Q-loop/lid; other site
760568001741	ABC transporter signature motif; other site
760568001742	Walker B; other site
760568001743	D-loop; other site
760568001744	H-loop/switch region; other site
760568001745	Smr domain; Region: Smr; pfam01713
760568001746	Transglycosylase; Region: Transgly; pfam00912
760568001747	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
760568001748	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
760568001749	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
760568001750	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
760568001751	active site
760568001752	HIGH motif; other site
760568001753	dimer interface [polypeptide binding]; other site
760568001754	KMSKS motif; other site
760568001755	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
760568001756	RNA binding surface [nucleotide binding]; other site
760568001757	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783
760568001758	NAD synthetase; Provisional; Region: PRK13980
760568001759	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
760568001760	homodimer interface [polypeptide binding]; other site
760568001761	NAD binding pocket [chemical binding]; other site
760568001762	ATP binding pocket [chemical binding]; other site
760568001763	Mg binding site [ion binding]; other site
760568001764	active-site loop [active]
760568001765	hypothetical protein; Validated; Region: PRK00110
760568001766	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
760568001767	active site
760568001768	putative DNA-binding cleft [nucleotide binding]; other site
760568001769	dimer interface [polypeptide binding]; other site
760568001770	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
760568001771	RuvA N terminal domain; Region: RuvA_N; pfam01330
760568001772	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
760568001773	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
760568001774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568001775	Walker A motif; other site
760568001776	ATP binding site [chemical binding]; other site
760568001777	Walker B motif; other site
760568001778	arginine finger; other site
760568001779	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
760568001780	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
760568001781	Ligand Binding Site [chemical binding]; other site
760568001782	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
760568001783	Stage II sporulation protein; Region: SpoIID; pfam08486
760568001784	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
760568001785	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
760568001786	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
760568001787	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
760568001788	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
760568001789	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
760568001790	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568001791	Zn2+ binding site [ion binding]; other site
760568001792	Mg2+ binding site [ion binding]; other site
760568001793	protein-export membrane protein SecD; Region: secD; TIGR01129
760568001794	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
760568001795	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
760568001796	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
760568001797	Protein export membrane protein; Region: SecD_SecF; pfam02355
760568001798	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
760568001799	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
760568001800	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
760568001801	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
760568001802	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
760568001803	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
760568001804	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
760568001805	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
760568001806	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
760568001807	transmembrane helices; other site
760568001808	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
760568001809	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
760568001810	trimer interface [polypeptide binding]; other site
760568001811	active site
760568001812	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
760568001813	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
760568001814	transmembrane helices; other site
760568001815	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
760568001816	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
760568001817	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
760568001818	Part of AAA domain; Region: AAA_19; pfam13245
760568001819	Family description; Region: UvrD_C_2; pfam13538
760568001820	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
760568001821	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
760568001822	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
760568001823	active site
760568001824	metal binding site [ion binding]; metal-binding site
760568001825	DNA binding site [nucleotide binding]
760568001826	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
760568001827	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
760568001828	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
760568001829	Walker A/P-loop; other site
760568001830	ATP binding site [chemical binding]; other site
760568001831	Q-loop/lid; other site
760568001832	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568001833	ABC transporter signature motif; other site
760568001834	Walker B; other site
760568001835	D-loop; other site
760568001836	H-loop/switch region; other site
760568001837	putative uracil/xanthine transporter; Provisional; Region: PRK11412
760568001838	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
760568001839	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
760568001840	PDGLE domain; Region: PDGLE; pfam13190
760568001841	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
760568001842	Protein of unknown function (DUF3680); Region: DUF3680; pfam12441
760568001843	Uncharacterized conserved protein [Function unknown]; Region: COG5464
760568001844	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
760568001845	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
760568001846	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568001847	active site
760568001848	NTP binding site [chemical binding]; other site
760568001849	metal binding triad [ion binding]; metal-binding site
760568001850	antibiotic binding site [chemical binding]; other site
760568001851	HEPN domain; Region: HEPN; cl00824
760568001852	Helix-turn-helix domain; Region: HTH_17; pfam12728
760568001853	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13647
760568001854	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
760568001855	Walker A/P-loop; other site
760568001856	ATP binding site [chemical binding]; other site
760568001857	Q-loop/lid; other site
760568001858	ABC transporter signature motif; other site
760568001859	Walker B; other site
760568001860	D-loop; other site
760568001861	H-loop/switch region; other site
760568001862	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
760568001863	putative active site [active]
760568001864	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
760568001865	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
760568001866	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
760568001867	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
760568001868	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
760568001869	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
760568001870	catalytic triad [active]
760568001871	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
760568001872	homotrimer interaction site [polypeptide binding]; other site
760568001873	putative active site [active]
760568001874	acetyl-CoA acetyltransferase; Provisional; Region: PRK08235
760568001875	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
760568001876	dimer interface [polypeptide binding]; other site
760568001877	active site
760568001878	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
760568001879	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
760568001880	FAD binding site [chemical binding]; other site
760568001881	homotetramer interface [polypeptide binding]; other site
760568001882	substrate binding pocket [chemical binding]; other site
760568001883	catalytic base [active]
760568001884	Coenzyme A transferase; Region: CoA_trans; smart00882
760568001885	Coenzyme A transferase; Region: CoA_trans; cl17247
760568001886	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
760568001887	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568001888	putative active site [active]
760568001889	heme pocket [chemical binding]; other site
760568001890	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568001891	putative active site [active]
760568001892	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568001893	Walker A motif; other site
760568001894	ATP binding site [chemical binding]; other site
760568001895	Walker B motif; other site
760568001896	arginine finger; other site
760568001897	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
760568001898	sporulation protein YhbH; Region: spore_yhbH; TIGR02877
760568001899	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
760568001900	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
760568001901	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
760568001902	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
760568001903	substrate binding site; other site
760568001904	metal-binding site
760568001905	Oligomer interface; other site
760568001906	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
760568001907	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
760568001908	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
760568001909	NADP binding site [chemical binding]; other site
760568001910	active site
760568001911	putative substrate binding site [chemical binding]; other site
760568001912	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
760568001913	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
760568001914	NAD binding site [chemical binding]; other site
760568001915	substrate binding site [chemical binding]; other site
760568001916	homodimer interface [polypeptide binding]; other site
760568001917	active site
760568001918	Flagellin N-methylase; Region: FliB; pfam03692
760568001919	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568001920	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
760568001921	Zn2+ binding site [ion binding]; other site
760568001922	Mg2+ binding site [ion binding]; other site
760568001923	circadian clock protein KaiC; Reviewed; Region: PRK09302
760568001924	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
760568001925	Walker A motif; other site
760568001926	ATP binding site [chemical binding]; other site
760568001927	Walker B motif; other site
760568001928	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
760568001929	Walker A motif; other site
760568001930	ATP binding site [chemical binding]; other site
760568001931	Walker B motif; other site
760568001932	Sensory domain found in PocR; Region: PocR; pfam10114
760568001933	GAF domain; Region: GAF_3; pfam13492
760568001934	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568001935	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568001936	metal binding site [ion binding]; metal-binding site
760568001937	active site
760568001938	I-site; other site
760568001939	Domain of unknown function (DUF955); Region: DUF955; pfam06114
760568001940	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568001941	non-specific DNA binding site [nucleotide binding]; other site
760568001942	salt bridge; other site
760568001943	sequence-specific DNA binding site [nucleotide binding]; other site
760568001944	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
760568001945	AAA domain; Region: AAA_30; pfam13604
760568001946	Family description; Region: UvrD_C_2; pfam13538
760568001947	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
760568001948	MarR family; Region: MarR_2; pfam12802
760568001949	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
760568001950	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
760568001951	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568001952	Walker A motif; other site
760568001953	ATP binding site [chemical binding]; other site
760568001954	Walker B motif; other site
760568001955	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
760568001956	Homeodomain-like domain; Region: HTH_23; pfam13384
760568001957	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
760568001958	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
760568001959	active site
760568001960	Helix-turn-helix domain; Region: HTH_38; pfam13936
760568001961	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
760568001962	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
760568001963	metal ion-dependent adhesion site (MIDAS); other site
760568001964	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
760568001965	RNA/DNA hybrid binding site [nucleotide binding]; other site
760568001966	active site
760568001967	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
760568001968	Probable transposase; Region: OrfB_IS605; pfam01385
760568001969	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
760568001970	SEC-C motif; Region: SEC-C; pfam02810
760568001971	Probable transposase; Region: OrfB_IS605; pfam01385
760568001972	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
760568001973	RRXRR protein; Region: RRXRR; pfam14239
760568001974	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
760568001975	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
760568001976	active site
760568001977	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
760568001978	oligomer interface [polypeptide binding]; other site
760568001979	AAA domain; Region: AAA_30; pfam13604
760568001980	Family description; Region: UvrD_C_2; pfam13538
760568001981	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
760568001982	Probable transposase; Region: OrfB_IS605; pfam01385
760568001983	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
760568001984	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
760568001985	CRISPR/Cas system-associated RAMP superfamily protein Csf2; Region: Csf2_U; cl11864
760568001986	CRISPR/Cas system-associated RAMP superfamily protein Csf3; Region: Csf3_U; cl11865
760568001987	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
760568001988	DNA methylase; Region: N6_N4_Mtase; cl17433
760568001989	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
760568001990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568001991	S-adenosylmethionine binding site [chemical binding]; other site
760568001992	Recombination protein U; Region: RecU; cl01314
760568001993	Ycf46; Provisional; Region: ycf46; CHL00195
760568001994	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568001995	Walker A motif; other site
760568001996	ATP binding site [chemical binding]; other site
760568001997	Walker B motif; other site
760568001998	arginine finger; other site
760568001999	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
760568002000	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
760568002001	Homeodomain-like domain; Region: HTH_23; cl17451
760568002002	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
760568002003	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
760568002004	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
760568002005	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
760568002006	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
760568002007	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
760568002008	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
760568002009	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
760568002010	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
760568002011	active site
760568002012	DNA binding site [nucleotide binding]
760568002013	Int/Topo IB signature motif; other site
760568002014	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442
760568002015	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
760568002016	Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298
760568002017	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
760568002018	Transposase; Region: DEDD_Tnp_IS110; pfam01548
760568002019	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
760568002020	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
760568002021	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
760568002022	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
760568002023	Transcriptional regulator [Transcription]; Region: IclR; COG1414
760568002024	Bacterial transcriptional regulator; Region: IclR; pfam01614
760568002025	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
760568002026	DctM-like transporters; Region: DctM; pfam06808
760568002027	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
760568002028	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
760568002029	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
760568002030	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
760568002031	CoA binding domain; Region: CoA_binding_2; pfam13380
760568002032	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
760568002033	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
760568002034	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
760568002035	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
760568002036	active site
760568002037	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
760568002038	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
760568002039	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
760568002040	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
760568002041	Ligand binding site [chemical binding]; other site
760568002042	Electron transfer flavoprotein domain; Region: ETF; pfam01012
760568002043	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
760568002044	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
760568002045	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
760568002046	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
760568002047	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
760568002048	substrate binding site [chemical binding]; other site
760568002049	oxyanion hole (OAH) forming residues; other site
760568002050	trimer interface [polypeptide binding]; other site
760568002051	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
760568002052	carboxyltransferase (CT) interaction site; other site
760568002053	biotinylation site [posttranslational modification]; other site
760568002054	putative acyltransferase; Provisional; Region: PRK05790
760568002055	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
760568002056	dimer interface [polypeptide binding]; other site
760568002057	active site
760568002058	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
760568002059	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
760568002060	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
760568002061	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
760568002062	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
760568002063	enoyl-CoA hydratase; Provisional; Region: PRK06688
760568002064	substrate binding site [chemical binding]; other site
760568002065	oxyanion hole (OAH) forming residues; other site
760568002066	trimer interface [polypeptide binding]; other site
760568002067	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263
760568002068	L-aspartate oxidase; Provisional; Region: PRK06175
760568002069	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
760568002070	bile acid transporter; Region: bass; TIGR00841
760568002071	Sodium Bile acid symporter family; Region: SBF; cl17470
760568002072	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
760568002073	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
760568002074	TM2 domain; Region: TM2; cl00984
760568002075	Domain of unknown function DUF87; Region: DUF87; pfam01935
760568002076	AAA-like domain; Region: AAA_10; pfam12846
760568002077	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
760568002078	Coenzyme A binding pocket [chemical binding]; other site
760568002079	ParB-like nuclease domain; Region: ParBc; pfam02195
760568002080	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
760568002081	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
760568002082	N-acetyl-D-glucosamine binding site [chemical binding]; other site
760568002083	catalytic residue [active]
760568002084	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
760568002085	Peptidase family M23; Region: Peptidase_M23; pfam01551
760568002086	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
760568002087	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
760568002088	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
760568002089	Walker A motif; other site
760568002090	ATP binding site [chemical binding]; other site
760568002091	Walker B motif; other site
760568002092	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
760568002093	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
760568002094	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
760568002095	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
760568002096	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
760568002097	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
760568002098	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
760568002099	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568002100	CARDB; Region: CARDB; pfam07705
760568002101	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
760568002102	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
760568002103	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
760568002104	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
760568002105	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
760568002106	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
760568002107	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
760568002108	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
760568002109	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
760568002110	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
760568002111	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
760568002112	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
760568002113	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
760568002114	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
760568002115	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
760568002116	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
760568002117	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
760568002118	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
760568002119	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
760568002120	AAA domain; Region: AAA_31; pfam13614
760568002121	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
760568002122	P-loop; other site
760568002123	Magnesium ion binding site [ion binding]; other site
760568002124	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
760568002125	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
760568002126	Type II/IV secretion system protein; Region: T2SE; pfam00437
760568002127	Walker A motif; other site
760568002128	ATP binding site [chemical binding]; other site
760568002129	Walker B motif; other site
760568002130	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
760568002131	CAAX protease self-immunity; Region: Abi; pfam02517
760568002132	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568002133	CARDB; Region: CARDB; pfam07705
760568002134	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
760568002135	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568002136	Zn2+ binding site [ion binding]; other site
760568002137	Mg2+ binding site [ion binding]; other site
760568002138	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568002139	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568002140	metal binding site [ion binding]; metal-binding site
760568002141	active site
760568002142	I-site; other site
760568002143	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
760568002144	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
760568002145	VanW like protein; Region: VanW; pfam04294
760568002146	Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005
760568002147	putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331
760568002148	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568002149	Zn2+ binding site [ion binding]; other site
760568002150	Mg2+ binding site [ion binding]; other site
760568002151	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
760568002152	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
760568002153	active site
760568002154	homodimer interface [polypeptide binding]; other site
760568002155	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
760568002156	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
760568002157	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
760568002158	Probable transposase; Region: OrfB_IS605; pfam01385
760568002159	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
760568002160	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
760568002161	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
760568002162	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
760568002163	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
760568002164	Methyltransferase domain; Region: Methyltransf_26; pfam13659
760568002165	Helix-turn-helix domain; Region: HTH_17; pfam12728
760568002166	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
760568002167	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
760568002168	PRTRC system protein D; Region: PRTRC_D; TIGR03739
760568002169	Mg binding site [ion binding]; other site
760568002170	nucleotide binding site [chemical binding]; other site
760568002171	putative protofilament interface [polypeptide binding]; other site
760568002172	Band 3 cytoplasmic domain; Region: Band_3_cyto; pfam07565
760568002173	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
760568002174	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
760568002175	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
760568002176	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
760568002177	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
760568002178	Walker A motif; other site
760568002179	ATP binding site [chemical binding]; other site
760568002180	Walker B motif; other site
760568002181	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
760568002182	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
760568002183	RNA binding site [nucleotide binding]; other site
760568002184	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
760568002185	RNA binding site [nucleotide binding]; other site
760568002186	PemK-like protein; Region: PemK; pfam02452
760568002187	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
760568002188	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
760568002189	ssDNA binding site [nucleotide binding]; other site
760568002190	dimer interface [polypeptide binding]; other site
760568002191	tetramer (dimer of dimers) interface [polypeptide binding]; other site
760568002192	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
760568002193	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
760568002194	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
760568002195	metal ion-dependent adhesion site (MIDAS); other site
760568002196	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
760568002197	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
760568002198	CHC2 zinc finger; Region: zf-CHC2; cl17510
760568002199	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
760568002200	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
760568002201	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
760568002202	ADP-ribose binding site [chemical binding]; other site
760568002203	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
760568002204	DNA polymerase III subunit beta; Validated; Region: PRK05643
760568002205	putative DNA binding surface [nucleotide binding]; other site
760568002206	dimer interface [polypeptide binding]; other site
760568002207	beta-clamp/clamp loader binding surface; other site
760568002208	beta-clamp/translesion DNA polymerase binding surface; other site
760568002209	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568002210	Walker A/P-loop; other site
760568002211	ATP binding site [chemical binding]; other site
760568002212	putative transposase; Provisional; Region: PHA02942
760568002213	HicB family; Region: HicB; pfam05534
760568002214	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
760568002215	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568002216	Walker A motif; other site
760568002217	ATP binding site [chemical binding]; other site
760568002218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568002219	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
760568002220	Walker A motif; other site
760568002221	ATP binding site [chemical binding]; other site
760568002222	Walker B motif; other site
760568002223	arginine finger; other site
760568002224	RQC domain; Region: RQC; cl09632
760568002225	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
760568002226	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
760568002227	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
760568002228	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
760568002229	active site
760568002230	metal binding site [ion binding]; metal-binding site
760568002231	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
760568002232	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568002233	Walker A motif; other site
760568002234	ATP binding site [chemical binding]; other site
760568002235	Walker B motif; other site
760568002236	arginine finger; other site
760568002237	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
760568002238	RQC domain; Region: RQC; pfam09382
760568002239	Methyltransferase domain; Region: Methyltransf_26; pfam13659
760568002240	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
760568002241	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
760568002242	putative Mg++ binding site [ion binding]; other site
760568002243	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
760568002244	nucleotide binding region [chemical binding]; other site
760568002245	ATP-binding site [chemical binding]; other site
760568002246	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
760568002247	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
760568002248	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
760568002249	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
760568002250	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
760568002251	catalytic residues [active]
760568002252	catalytic nucleophile [active]
760568002253	Recombinase; Region: Recombinase; pfam07508
760568002254	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
760568002255	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
760568002256	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
760568002257	G1 box; other site
760568002258	GTP/Mg2+ binding site [chemical binding]; other site
760568002259	Switch I region; other site
760568002260	G2 box; other site
760568002261	G3 box; other site
760568002262	Switch II region; other site
760568002263	G4 box; other site
760568002264	G5 box; other site
760568002265	FeoA domain; Region: FeoA; pfam04023
760568002266	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
760568002267	GAF domain; Region: GAF; pfam01590
760568002268	HDOD domain; Region: HDOD; pfam08668
760568002269	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568002270	Zn2+ binding site [ion binding]; other site
760568002271	Mg2+ binding site [ion binding]; other site
760568002272	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
760568002273	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
760568002274	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
760568002275	catalytic residues [active]
760568002276	catalytic nucleophile [active]
760568002277	Recombinase; Region: Recombinase; pfam07508
760568002278	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
760568002279	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568002280	active site
760568002281	NTP binding site [chemical binding]; other site
760568002282	metal binding triad [ion binding]; metal-binding site
760568002283	antibiotic binding site [chemical binding]; other site
760568002284	HEPN domain; Region: HEPN; pfam05168
760568002285	Helix-turn-helix domain; Region: HTH_36; pfam13730
760568002286	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
760568002287	AAA-like domain; Region: AAA_10; pfam12846
760568002288	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
760568002289	Replication-relaxation; Region: Replic_Relax; pfam13814
760568002290	Protein of unknown function (DUF3782); Region: DUF3782; pfam12644
760568002291	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
760568002292	Catalytic site [active]
760568002293	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568002294	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
760568002295	Helix-turn-helix domain; Region: HTH_31; pfam13560
760568002296	non-specific DNA binding site [nucleotide binding]; other site
760568002297	salt bridge; other site
760568002298	sequence-specific DNA binding site [nucleotide binding]; other site
760568002299	Haemagglutinin; Region: Hemagglutinin; pfam00509
760568002300	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
760568002301	SpoVR like protein; Region: SpoVR; pfam04293
760568002302	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
760568002303	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568002304	FeS/SAM binding site; other site
760568002305	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
760568002306	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
760568002307	putative DNA binding site [nucleotide binding]; other site
760568002308	putative homodimer interface [polypeptide binding]; other site
760568002309	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
760568002310	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
760568002311	active site
760568002312	DNA binding site [nucleotide binding]
760568002313	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
760568002314	DNA binding site [nucleotide binding]
760568002315	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
760568002316	nucleotide binding site [chemical binding]; other site
760568002317	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
760568002318	DNA protecting protein DprA; Region: dprA; TIGR00732
760568002319	DNA topoisomerase I; Validated; Region: PRK05582
760568002320	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
760568002321	active site
760568002322	interdomain interaction site; other site
760568002323	putative metal-binding site [ion binding]; other site
760568002324	nucleotide binding site [chemical binding]; other site
760568002325	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
760568002326	domain I; other site
760568002327	DNA binding groove [nucleotide binding]
760568002328	phosphate binding site [ion binding]; other site
760568002329	domain II; other site
760568002330	domain III; other site
760568002331	nucleotide binding site [chemical binding]; other site
760568002332	catalytic site [active]
760568002333	domain IV; other site
760568002334	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
760568002335	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
760568002336	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
760568002337	Glucose inhibited division protein A; Region: GIDA; pfam01134
760568002338	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
760568002339	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
760568002340	active site
760568002341	Int/Topo IB signature motif; other site
760568002342	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
760568002343	active site
760568002344	HslU subunit interaction site [polypeptide binding]; other site
760568002345	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
760568002346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568002347	Walker A motif; other site
760568002348	ATP binding site [chemical binding]; other site
760568002349	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
760568002350	Walker B motif; other site
760568002351	arginine finger; other site
760568002352	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
760568002353	transcriptional repressor CodY; Validated; Region: PRK04158
760568002354	CodY GAF-like domain; Region: CodY; pfam06018
760568002355	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
760568002356	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
760568002357	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
760568002358	ligand binding site [chemical binding]; other site
760568002359	flexible hinge region; other site
760568002360	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
760568002361	putative switch regulator; other site
760568002362	non-specific DNA interactions [nucleotide binding]; other site
760568002363	DNA binding site [nucleotide binding]
760568002364	sequence specific DNA binding site [nucleotide binding]; other site
760568002365	putative cAMP binding site [chemical binding]; other site
760568002366	oligosaccharide amylase; Region: oligosac_amyl; TIGR01577
760568002367	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
760568002368	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
760568002369	catalytic loop [active]
760568002370	iron binding site [ion binding]; other site
760568002371	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
760568002372	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
760568002373	4Fe-4S binding domain; Region: Fer4; pfam00037
760568002374	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
760568002375	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
760568002376	Protein of unknown function (DUF342); Region: DUF342; pfam03961
760568002377	Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739
760568002378	Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918
760568002379	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
760568002380	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
760568002381	putative dimer interface [polypeptide binding]; other site
760568002382	active site pocket [active]
760568002383	putative cataytic base [active]
760568002384	Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950
760568002385	Uncharacterized conserved protein [Function unknown]; Region: COG1751
760568002386	Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887
760568002387	Cyclophilin-like; Region: Cyclophil_like; pfam04126
760568002388	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
760568002389	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
760568002390	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
760568002391	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
760568002392	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
760568002393	DNA binding residues [nucleotide binding]
760568002394	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
760568002395	catalytic residues [active]
760568002396	catalytic nucleophile [active]
760568002397	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
760568002398	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
760568002399	dimer interface [polypeptide binding]; other site
760568002400	putative CheW interface [polypeptide binding]; other site
760568002401	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
760568002402	dimer interface [polypeptide binding]; other site
760568002403	putative CheW interface [polypeptide binding]; other site
760568002404	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
760568002405	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
760568002406	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
760568002407	putative CheA interaction surface; other site
760568002408	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
760568002409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568002410	active site
760568002411	phosphorylation site [posttranslational modification]
760568002412	intermolecular recognition site; other site
760568002413	CheB methylesterase; Region: CheB_methylest; pfam01339
760568002414	HEAT repeats; Region: HEAT_2; pfam13646
760568002415	HEAT repeats; Region: HEAT_2; pfam13646
760568002416	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
760568002417	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
760568002418	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
760568002419	Response regulator receiver domain; Region: Response_reg; pfam00072
760568002420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568002421	active site
760568002422	phosphorylation site [posttranslational modification]
760568002423	intermolecular recognition site; other site
760568002424	dimerization interface [polypeptide binding]; other site
760568002425	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
760568002426	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
760568002427	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568002428	ATP binding site [chemical binding]; other site
760568002429	Mg2+ binding site [ion binding]; other site
760568002430	G-X-G motif; other site
760568002431	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
760568002432	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
760568002433	putative binding surface; other site
760568002434	active site
760568002435	P2 response regulator binding domain; Region: P2; pfam07194
760568002436	Response regulator receiver domain; Region: Response_reg; pfam00072
760568002437	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568002438	active site
760568002439	phosphorylation site [posttranslational modification]
760568002440	intermolecular recognition site; other site
760568002441	dimerization interface [polypeptide binding]; other site
760568002442	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
760568002443	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568002444	Zn2+ binding site [ion binding]; other site
760568002445	Mg2+ binding site [ion binding]; other site
760568002446	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
760568002447	dimer interface [polypeptide binding]; other site
760568002448	putative CheW interface [polypeptide binding]; other site
760568002449	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
760568002450	Protein of unknown function (DUF1284); Region: DUF1284; cl01419
760568002451	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
760568002452	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
760568002453	SEC-C motif; Region: SEC-C; pfam02810
760568002454	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
760568002455	Transposase; Region: HTH_Tnp_1; pfam01527
760568002456	putative transposase OrfB; Reviewed; Region: PHA02517
760568002457	HTH-like domain; Region: HTH_21; pfam13276
760568002458	Integrase core domain; Region: rve; pfam00665
760568002459	Integrase core domain; Region: rve_3; pfam13683
760568002460	WYL domain; Region: WYL; pfam13280
760568002461	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568002462	Inhibitor of growth proteins N-terminal histone-binding; Region: ING; pfam12998
760568002463	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
760568002464	Transposase [DNA replication, recombination, and repair]; Region: COG5421
760568002465	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
760568002466	active site
760568002467	metal binding site [ion binding]; metal-binding site
760568002468	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
760568002469	Predicted RNA binding protein (dsRBD-like fold), HicA family    [General function prediction only]; Region: COG1724
760568002470	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
760568002471	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568002472	non-specific DNA binding site [nucleotide binding]; other site
760568002473	salt bridge; other site
760568002474	sequence-specific DNA binding site [nucleotide binding]; other site
760568002475	HIRAN domain; Region: HIRAN; pfam08797
760568002476	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
760568002477	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
760568002478	Int/Topo IB signature motif; other site
760568002479	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
760568002480	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
760568002481	peptide binding site [polypeptide binding]; other site
760568002482	AP endonuclease family 2; Region: AP2Ec; smart00518
760568002483	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
760568002484	Metal-binding active site; metal-binding site
760568002485	AP (apurinic/apyrimidinic) site pocket; other site
760568002486	pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285
760568002487	spermidine synthase; Provisional; Region: PRK00811
760568002488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568002489	S-adenosylmethionine binding site [chemical binding]; other site
760568002490	agmatinase; Region: agmatinase; TIGR01230
760568002491	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
760568002492	putative active site [active]
760568002493	Mn binding site [ion binding]; other site
760568002494	AAA domain; Region: AAA_32; pfam13654
760568002495	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
760568002496	ABC transporter; Region: ABC_tran_2; pfam12848
760568002497	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
760568002498	ATP-sulfurylase; Region: ATPS; cd00517
760568002499	active site
760568002500	HXXH motif; other site
760568002501	flexible loop; other site
760568002502	adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060
760568002503	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
760568002504	Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139
760568002505	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
760568002506	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
760568002507	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
760568002508	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
760568002509	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
760568002510	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568002511	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
760568002512	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
760568002513	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568002514	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
760568002515	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
760568002516	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568002517	Cysteine-rich domain; Region: CCG; pfam02754
760568002518	Cysteine-rich domain; Region: CCG; pfam02754
760568002519	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
760568002520	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
760568002521	SPW repeat; Region: SPW; pfam03779
760568002522	Peptidase family M48; Region: Peptidase_M48; cl12018
760568002523	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
760568002524	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
760568002525	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
760568002526	active site
760568002527	catalytic residues [active]
760568002528	DNA binding site [nucleotide binding]
760568002529	Int/Topo IB signature motif; other site
760568002530	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
760568002531	amidase catalytic site [active]
760568002532	Zn binding residues [ion binding]; other site
760568002533	substrate binding site [chemical binding]; other site
760568002534	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568002535	Global regulator protein family; Region: CsrA; pfam02599
760568002536	flagellin; Reviewed; Region: PRK08869
760568002537	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
760568002538	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
760568002539	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
760568002540	Galactose oxidase, central domain; Region: Kelch_3; cl02701
760568002541	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
760568002542	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
760568002543	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
760568002544	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
760568002545	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
760568002546	Kelch motif; Region: Kelch_1; pfam01344
760568002547	Kelch motif; Region: Kelch_1; pfam01344
760568002548	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
760568002549	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
760568002550	membrane protein P6; Region: PHA01399
760568002551	membrane protein P6; Region: PHA01399
760568002552	Phage-related protein [Function unknown]; Region: COG5412
760568002553	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
760568002554	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
760568002555	Minor capsid protein; Region: Minor_capsid_2; pfam11114
760568002556	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
760568002557	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
760568002558	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
760568002559	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
760568002560	DNA-binding interface [nucleotide binding]; DNA binding site
760568002561	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
760568002562	Terminase-like family; Region: Terminase_6; pfam03237
760568002563	Phage terminase large subunit; Region: Terminase_3; cl12054
760568002564	Homeodomain-like domain; Region: HTH_23; pfam13384
760568002565	ParB-like nuclease domain; Region: ParB; smart00470
760568002566	MT-A70; Region: MT-A70; cl01947
760568002567	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
760568002568	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
760568002569	active site
760568002570	metal binding site [ion binding]; metal-binding site
760568002571	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
760568002572	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
760568002573	Walker A motif; other site
760568002574	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
760568002575	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
760568002576	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
760568002577	protein binding site [polypeptide binding]; other site
760568002578	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
760568002579	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
760568002580	acyl-activating enzyme (AAE) consensus motif; other site
760568002581	putative AMP binding site [chemical binding]; other site
760568002582	putative active site [active]
760568002583	putative CoA binding site [chemical binding]; other site
760568002584	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
760568002585	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
760568002586	NodB motif; other site
760568002587	putative active site [active]
760568002588	putative catalytic site [active]
760568002589	putative Zn binding site [ion binding]; other site
760568002590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568002591	Major Facilitator Superfamily; Region: MFS_1; pfam07690
760568002592	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
760568002593	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
760568002594	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
760568002595	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
760568002596	metal binding site 2 [ion binding]; metal-binding site
760568002597	putative DNA binding helix; other site
760568002598	metal binding site 1 [ion binding]; metal-binding site
760568002599	dimer interface [polypeptide binding]; other site
760568002600	structural Zn2+ binding site [ion binding]; other site
760568002601	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
760568002602	Uncharacterized conserved protein [Function unknown]; Region: COG1543
760568002603	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
760568002604	active site
760568002605	substrate binding site [chemical binding]; other site
760568002606	catalytic site [active]
760568002607	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
760568002608	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
760568002609	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
760568002610	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
760568002611	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
760568002612	nucleophile elbow; other site
760568002613	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
760568002614	histidinol-phosphatase; Provisional; Region: PRK07328
760568002615	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
760568002616	active site
760568002617	dimer interface [polypeptide binding]; other site
760568002618	cell division protein MraZ; Reviewed; Region: PRK00326
760568002619	MraZ protein; Region: MraZ; pfam02381
760568002620	MraZ protein; Region: MraZ; pfam02381
760568002621	MraW methylase family; Region: Methyltransf_5; pfam01795
760568002622	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
760568002623	Cell division protein FtsL; Region: FtsL; cl11433
760568002624	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
760568002625	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
760568002626	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
760568002627	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
760568002628	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
760568002629	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
760568002630	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
760568002631	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
760568002632	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
760568002633	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
760568002634	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
760568002635	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
760568002636	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
760568002637	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
760568002638	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
760568002639	Mg++ binding site [ion binding]; other site
760568002640	putative catalytic motif [active]
760568002641	putative substrate binding site [chemical binding]; other site
760568002642	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
760568002643	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
760568002644	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
760568002645	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
760568002646	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
760568002647	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
760568002648	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
760568002649	active site
760568002650	homodimer interface [polypeptide binding]; other site
760568002651	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
760568002652	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
760568002653	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
760568002654	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
760568002655	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
760568002656	FAD binding domain; Region: FAD_binding_4; pfam01565
760568002657	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
760568002658	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
760568002659	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
760568002660	hinge; other site
760568002661	active site
760568002662	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
760568002663	Cell division protein FtsQ; Region: FtsQ; pfam03799
760568002664	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
760568002665	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
760568002666	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
760568002667	cell division protein FtsA; Region: ftsA; TIGR01174
760568002668	Cell division protein FtsA; Region: FtsA; smart00842
760568002669	Cell division protein FtsA; Region: FtsA; pfam14450
760568002670	cell division protein FtsZ; Validated; Region: PRK09330
760568002671	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
760568002672	nucleotide binding site [chemical binding]; other site
760568002673	SulA interaction site; other site
760568002674	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
760568002675	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
760568002676	sporulation sigma factor SigE; Reviewed; Region: PRK08301
760568002677	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
760568002678	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
760568002679	DNA binding residues [nucleotide binding]
760568002680	sporulation sigma factor SigG; Reviewed; Region: PRK08215
760568002681	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
760568002682	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
760568002683	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
760568002684	DNA binding residues [nucleotide binding]
760568002685	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
760568002686	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
760568002687	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
760568002688	ATP cone domain; Region: ATP-cone; pfam03477
760568002689	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
760568002690	ATP cone domain; Region: ATP-cone; pfam03477
760568002691	Class III ribonucleotide reductase; Region: RNR_III; cd01675
760568002692	effector binding site; other site
760568002693	active site
760568002694	Zn binding site [ion binding]; other site
760568002695	glycine loop; other site
760568002696	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
760568002697	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568002698	FeS/SAM binding site; other site
760568002699	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
760568002700	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
760568002701	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
760568002702	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
760568002703	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
760568002704	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
760568002705	Beta-Casp domain; Region: Beta-Casp; smart01027
760568002706	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
760568002707	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
760568002708	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
760568002709	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
760568002710	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568002711	active site
760568002712	phosphorylation site [posttranslational modification]
760568002713	intermolecular recognition site; other site
760568002714	dimerization interface [polypeptide binding]; other site
760568002715	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
760568002716	DNA binding site [nucleotide binding]
760568002717	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
760568002718	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
760568002719	dimerization interface [polypeptide binding]; other site
760568002720	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
760568002721	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568002722	putative active site [active]
760568002723	heme pocket [chemical binding]; other site
760568002724	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
760568002725	dimer interface [polypeptide binding]; other site
760568002726	phosphorylation site [posttranslational modification]
760568002727	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568002728	ATP binding site [chemical binding]; other site
760568002729	Mg2+ binding site [ion binding]; other site
760568002730	G-X-G motif; other site
760568002731	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
760568002732	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
760568002733	Walker A/P-loop; other site
760568002734	ATP binding site [chemical binding]; other site
760568002735	Q-loop/lid; other site
760568002736	ABC transporter signature motif; other site
760568002737	Walker B; other site
760568002738	D-loop; other site
760568002739	H-loop/switch region; other site
760568002740	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
760568002741	PhoU domain; Region: PhoU; pfam01895
760568002742	PhoU domain; Region: PhoU; pfam01895
760568002743	HlyD family secretion protein; Region: HlyD_2; pfam12700
760568002744	putative membrane fusion protein; Region: TIGR02828
760568002745	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
760568002746	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
760568002747	catalytic residue [active]
760568002748	Protein of unknown function (DUF552); Region: DUF552; pfam04472
760568002749	pyrroline-5-carboxylate reductase; Region: PLN02688
760568002750	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
760568002751	YGGT family; Region: YGGT; pfam02325
760568002752	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
760568002753	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
760568002754	RNA binding surface [nucleotide binding]; other site
760568002755	Uncharacterized conserved protein [Function unknown]; Region: COG1872
760568002756	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
760568002757	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
760568002758	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
760568002759	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
760568002760	active site
760568002761	HIGH motif; other site
760568002762	nucleotide binding site [chemical binding]; other site
760568002763	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
760568002764	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
760568002765	active site
760568002766	KMSKS motif; other site
760568002767	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
760568002768	tRNA binding surface [nucleotide binding]; other site
760568002769	anticodon binding site; other site
760568002770	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
760568002771	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
760568002772	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
760568002773	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568002774	FeS/SAM binding site; other site
760568002775	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
760568002776	Homeodomain-like domain; Region: HTH_23; pfam13384
760568002777	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
760568002778	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
760568002779	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
760568002780	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
760568002781	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
760568002782	active site
760568002783	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
760568002784	Coenzyme A binding pocket [chemical binding]; other site
760568002785	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319
760568002786	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
760568002787	putative active site [active]
760568002788	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
760568002789	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568002790	active site
760568002791	phosphorylation site [posttranslational modification]
760568002792	intermolecular recognition site; other site
760568002793	dimerization interface [polypeptide binding]; other site
760568002794	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
760568002795	DNA binding site [nucleotide binding]
760568002796	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
760568002797	dimerization interface [polypeptide binding]; other site
760568002798	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
760568002799	dimer interface [polypeptide binding]; other site
760568002800	phosphorylation site [posttranslational modification]
760568002801	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568002802	ATP binding site [chemical binding]; other site
760568002803	Mg2+ binding site [ion binding]; other site
760568002804	G-X-G motif; other site
760568002805	Protein of unknown function (DUF2680); Region: DUF2680; pfam10925
760568002806	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
760568002807	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
760568002808	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
760568002809	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
760568002810	catalytic residue [active]
760568002811	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
760568002812	B12 binding site [chemical binding]; other site
760568002813	cobalt ligand [ion binding]; other site
760568002814	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
760568002815	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
760568002816	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
760568002817	Walker A; other site
760568002818	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
760568002819	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
760568002820	homodimer interface [polypeptide binding]; other site
760568002821	Walker A motif; other site
760568002822	ATP binding site [chemical binding]; other site
760568002823	hydroxycobalamin binding site [chemical binding]; other site
760568002824	Walker B motif; other site
760568002825	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
760568002826	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
760568002827	FAD binding site [chemical binding]; other site
760568002828	homotetramer interface [polypeptide binding]; other site
760568002829	substrate binding pocket [chemical binding]; other site
760568002830	catalytic base [active]
760568002831	acetyl-CoA acetyltransferase; Provisional; Region: PRK08235
760568002832	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
760568002833	dimer interface [polypeptide binding]; other site
760568002834	active site
760568002835	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
760568002836	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
760568002837	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
760568002838	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
760568002839	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
760568002840	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
760568002841	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
760568002842	putative dimer interface [polypeptide binding]; other site
760568002843	Domain of unknown function (DUF3786); Region: DUF3786; pfam12654
760568002844	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
760568002845	dimer interface [polypeptide binding]; other site
760568002846	ADP-ribose binding site [chemical binding]; other site
760568002847	active site
760568002848	nudix motif; other site
760568002849	metal binding site [ion binding]; metal-binding site
760568002850	septum formation inhibitor; Reviewed; Region: minC; PRK00513
760568002851	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
760568002852	Domain of unknown function DUF77; Region: DUF77; pfam01910
760568002853	ADP-glucose phosphorylase; Region: PLN02643
760568002854	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
760568002855	nucleotide binding site/active site [active]
760568002856	HIT family signature motif; other site
760568002857	catalytic residue [active]
760568002858	glycogen synthase; Provisional; Region: glgA; PRK00654
760568002859	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
760568002860	ADP-binding pocket [chemical binding]; other site
760568002861	homodimer interface [polypeptide binding]; other site
760568002862	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
760568002863	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568002864	Walker A motif; other site
760568002865	ATP binding site [chemical binding]; other site
760568002866	Walker B motif; other site
760568002867	arginine finger; other site
760568002868	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
760568002869	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
760568002870	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
760568002871	FAD binding site [chemical binding]; other site
760568002872	homotetramer interface [polypeptide binding]; other site
760568002873	substrate binding pocket [chemical binding]; other site
760568002874	catalytic base [active]
760568002875	FeoC like transcriptional regulator; Region: FeoC; cl17677
760568002876	acetyl-CoA synthetase; Provisional; Region: PRK00174
760568002877	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
760568002878	acyl-activating enzyme (AAE) consensus motif; other site
760568002879	AMP binding site [chemical binding]; other site
760568002880	active site
760568002881	CoA binding site [chemical binding]; other site
760568002882	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
760568002883	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
760568002884	acyl-activating enzyme (AAE) consensus motif; other site
760568002885	AMP binding site [chemical binding]; other site
760568002886	active site
760568002887	CoA binding site [chemical binding]; other site
760568002888	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
760568002889	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
760568002890	FAD binding site [chemical binding]; other site
760568002891	homotetramer interface [polypeptide binding]; other site
760568002892	substrate binding pocket [chemical binding]; other site
760568002893	catalytic base [active]
760568002894	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
760568002895	Ligand binding site [chemical binding]; other site
760568002896	Electron transfer flavoprotein domain; Region: ETF; pfam01012
760568002897	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
760568002898	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
760568002899	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
760568002900	putative acyltransferase; Provisional; Region: PRK05790
760568002901	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
760568002902	dimer interface [polypeptide binding]; other site
760568002903	active site
760568002904	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
760568002905	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
760568002906	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
760568002907	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
760568002908	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
760568002909	substrate binding site [chemical binding]; other site
760568002910	oxyanion hole (OAH) forming residues; other site
760568002911	trimer interface [polypeptide binding]; other site
760568002912	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568002913	non-specific DNA binding site [nucleotide binding]; other site
760568002914	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
760568002915	salt bridge; other site
760568002916	sequence-specific DNA binding site [nucleotide binding]; other site
760568002917	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
760568002918	Catalytic site [active]
760568002919	FOG: CBS domain [General function prediction only]; Region: COG0517
760568002920	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
760568002921	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
760568002922	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
760568002923	DNA-binding site [nucleotide binding]; DNA binding site
760568002924	TrkA-C domain; Region: TrkA_C; pfam02080
760568002925	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
760568002926	acetyl-CoA synthetase; Provisional; Region: PRK00174
760568002927	acyl-activating enzyme (AAE) consensus motif; other site
760568002928	AMP binding site [chemical binding]; other site
760568002929	active site
760568002930	CoA binding site [chemical binding]; other site
760568002931	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
760568002932	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
760568002933	catalytic motif [active]
760568002934	Zn binding site [ion binding]; other site
760568002935	RibD C-terminal domain; Region: RibD_C; cl17279
760568002936	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
760568002937	Lumazine binding domain; Region: Lum_binding; pfam00677
760568002938	Lumazine binding domain; Region: Lum_binding; pfam00677
760568002939	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
760568002940	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
760568002941	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
760568002942	dimerization interface [polypeptide binding]; other site
760568002943	active site
760568002944	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
760568002945	homopentamer interface [polypeptide binding]; other site
760568002946	active site
760568002947	nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662
760568002948	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571
760568002949	active site
760568002950	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
760568002951	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
760568002952	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
760568002953	generic binding surface II; other site
760568002954	ssDNA binding site; other site
760568002955	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
760568002956	ATP binding site [chemical binding]; other site
760568002957	putative Mg++ binding site [ion binding]; other site
760568002958	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
760568002959	nucleotide binding region [chemical binding]; other site
760568002960	ATP-binding site [chemical binding]; other site
760568002961	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
760568002962	germination protease; Provisional; Region: PRK12362
760568002963	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
760568002964	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568002965	S-adenosylmethionine binding site [chemical binding]; other site
760568002966	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
760568002967	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
760568002968	active site
760568002969	(T/H)XGH motif; other site
760568002970	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
760568002971	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
760568002972	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
760568002973	DRTGG domain; Region: DRTGG; pfam07085
760568002974	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
760568002975	CoA binding domain; Region: CoA_binding_2; pfam13380
760568002976	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
760568002977	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
760568002978	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
760568002979	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
760568002980	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
760568002981	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
760568002982	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
760568002983	active site
760568002984	homotetramer interface [polypeptide binding]; other site
760568002985	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
760568002986	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
760568002987	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
760568002988	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
760568002989	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
760568002990	Nucleoside recognition; Region: Gate; pfam07670
760568002991	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
760568002992	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
760568002993	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
760568002994	active site
760568002995	metal binding site [ion binding]; metal-binding site
760568002996	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
760568002997	aspartate aminotransferase; Provisional; Region: PRK06836
760568002998	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
760568002999	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568003000	homodimer interface [polypeptide binding]; other site
760568003001	catalytic residue [active]
760568003002	pyrophosphatase PpaX; Provisional; Region: PRK13288
760568003003	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
760568003004	motif II; other site
760568003005	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
760568003006	catalytic residues [active]
760568003007	Predicted transcriptional regulator [Transcription]; Region: COG1959
760568003008	Transcriptional regulator; Region: Rrf2; pfam02082
760568003009	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
760568003010	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
760568003011	putative catalytic cysteine [active]
760568003012	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
760568003013	putative active site [active]
760568003014	metal binding site [ion binding]; metal-binding site
760568003015	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
760568003016	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
760568003017	transmembrane helices; other site
760568003018	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
760568003019	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
760568003020	active site
760568003021	lipoprotein signal peptidase; Provisional; Region: PRK14787
760568003022	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
760568003023	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
760568003024	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
760568003025	RNA binding surface [nucleotide binding]; other site
760568003026	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
760568003027	active site
760568003028	Protein of unknown function (DUF441); Region: DUF441; pfam04284
760568003029	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679
760568003030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568003031	Major Facilitator Superfamily; Region: MFS_1; pfam07690
760568003032	putative substrate translocation pore; other site
760568003033	Protein of unknown function (DUF2619); Region: DUF2619; pfam10942
760568003034	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
760568003035	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
760568003036	active site
760568003037	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
760568003038	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
760568003039	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
760568003040	dihydroorotase; Validated; Region: pyrC; PRK09357
760568003041	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
760568003042	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
760568003043	active site
760568003044	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
760568003045	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
760568003046	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
760568003047	catalytic site [active]
760568003048	subunit interface [polypeptide binding]; other site
760568003049	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
760568003050	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
760568003051	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
760568003052	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
760568003053	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
760568003054	ATP-grasp domain; Region: ATP-grasp_4; cl17255
760568003055	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
760568003056	IMP binding site; other site
760568003057	dimer interface [polypeptide binding]; other site
760568003058	interdomain contacts; other site
760568003059	partial ornithine binding site; other site
760568003060	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
760568003061	putative active site [active]
760568003062	putative metal binding site [ion binding]; other site
760568003063	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
760568003064	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
760568003065	FAD binding pocket [chemical binding]; other site
760568003066	FAD binding motif [chemical binding]; other site
760568003067	phosphate binding motif [ion binding]; other site
760568003068	beta-alpha-beta structure motif; other site
760568003069	NAD binding pocket [chemical binding]; other site
760568003070	Iron coordination center [ion binding]; other site
760568003071	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
760568003072	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
760568003073	heterodimer interface [polypeptide binding]; other site
760568003074	active site
760568003075	FMN binding site [chemical binding]; other site
760568003076	homodimer interface [polypeptide binding]; other site
760568003077	substrate binding site [chemical binding]; other site
760568003078	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
760568003079	active site
760568003080	dimer interface [polypeptide binding]; other site
760568003081	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
760568003082	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
760568003083	active site
760568003084	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
760568003085	alanine racemase; Reviewed; Region: alr; PRK00053
760568003086	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
760568003087	active site
760568003088	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
760568003089	dimer interface [polypeptide binding]; other site
760568003090	substrate binding site [chemical binding]; other site
760568003091	catalytic residues [active]
760568003092	BioY family; Region: BioY; pfam02632
760568003093	AAA domain; Region: AAA_26; pfam13500
760568003094	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
760568003095	ADP binding site [chemical binding]; other site
760568003096	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
760568003097	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
760568003098	inhibitor-cofactor binding pocket; inhibition site
760568003099	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568003100	catalytic residue [active]
760568003101	biotin synthase; Region: bioB; TIGR00433
760568003102	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568003103	FeS/SAM binding site; other site
760568003104	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
760568003105	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
760568003106	Domain of unknown function (DUF814); Region: DUF814; pfam05670
760568003107	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
760568003108	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
760568003109	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
760568003110	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
760568003111	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
760568003112	motif II; other site
760568003113	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
760568003114	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
760568003115	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
760568003116	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
760568003117	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
760568003118	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
760568003119	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568003120	homodimer interface [polypeptide binding]; other site
760568003121	catalytic residue [active]
760568003122	aspartate aminotransferase; Provisional; Region: PRK05764
760568003123	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
760568003124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568003125	homodimer interface [polypeptide binding]; other site
760568003126	catalytic residue [active]
760568003127	hypothetical protein; Provisional; Region: PRK11820
760568003128	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
760568003129	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
760568003130	hypothetical protein; Provisional; Region: PRK04323
760568003131	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
760568003132	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
760568003133	catalytic site [active]
760568003134	G-X2-G-X-G-K; other site
760568003135	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
760568003136	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
760568003137	Flavoprotein; Region: Flavoprotein; pfam02441
760568003138	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
760568003139	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
760568003140	putative DNA binding site [nucleotide binding]; other site
760568003141	putative Zn2+ binding site [ion binding]; other site
760568003142	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
760568003143	MarR family; Region: MarR; pfam01047
760568003144	primosome assembly protein PriA; Validated; Region: PRK05580
760568003145	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
760568003146	ATP binding site [chemical binding]; other site
760568003147	putative Mg++ binding site [ion binding]; other site
760568003148	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
760568003149	ATP-binding site [chemical binding]; other site
760568003150	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
760568003151	active site
760568003152	catalytic residues [active]
760568003153	metal binding site [ion binding]; metal-binding site
760568003154	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
760568003155	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
760568003156	putative active site [active]
760568003157	substrate binding site [chemical binding]; other site
760568003158	putative cosubstrate binding site; other site
760568003159	catalytic site [active]
760568003160	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
760568003161	substrate binding site [chemical binding]; other site
760568003162	Protein of unknown function DUF116; Region: DUF116; pfam01976
760568003163	16S rRNA methyltransferase B; Provisional; Region: PRK14902
760568003164	NusB family; Region: NusB; pfam01029
760568003165	putative RNA binding site [nucleotide binding]; other site
760568003166	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568003167	S-adenosylmethionine binding site [chemical binding]; other site
760568003168	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
760568003169	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568003170	FeS/SAM binding site; other site
760568003171	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
760568003172	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
760568003173	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
760568003174	phosphopeptide binding site; other site
760568003175	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
760568003176	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
760568003177	phosphopeptide binding site; other site
760568003178	Protein phosphatase 2C; Region: PP2C; pfam00481
760568003179	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
760568003180	active site
760568003181	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
760568003182	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
760568003183	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
760568003184	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
760568003185	Catalytic domain of Protein Kinases; Region: PKc; cd00180
760568003186	active site
760568003187	ATP binding site [chemical binding]; other site
760568003188	substrate binding site [chemical binding]; other site
760568003189	activation loop (A-loop); other site
760568003190	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
760568003191	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
760568003192	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
760568003193	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
760568003194	GTPase RsgA; Reviewed; Region: PRK00098
760568003195	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
760568003196	RNA binding site [nucleotide binding]; other site
760568003197	homodimer interface [polypeptide binding]; other site
760568003198	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
760568003199	GTPase/Zn-binding domain interface [polypeptide binding]; other site
760568003200	GTP/Mg2+ binding site [chemical binding]; other site
760568003201	G4 box; other site
760568003202	G5 box; other site
760568003203	G1 box; other site
760568003204	Switch I region; other site
760568003205	G2 box; other site
760568003206	G3 box; other site
760568003207	Switch II region; other site
760568003208	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
760568003209	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
760568003210	substrate binding site [chemical binding]; other site
760568003211	hexamer interface [polypeptide binding]; other site
760568003212	metal binding site [ion binding]; metal-binding site
760568003213	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
760568003214	iron binding site [ion binding]; other site
760568003215	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
760568003216	putative CheA interaction surface; other site
760568003217	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
760568003218	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568003219	Walker A/P-loop; other site
760568003220	ATP binding site [chemical binding]; other site
760568003221	ABC transporter signature motif; other site
760568003222	Walker B; other site
760568003223	D-loop; other site
760568003224	Protein of unknown function (DUF964); Region: DUF964; pfam06133
760568003225	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
760568003226	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
760568003227	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568003228	FeS/SAM binding site; other site
760568003229	TRAM domain; Region: TRAM; pfam01938
760568003230	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
760568003231	MutS domain I; Region: MutS_I; pfam01624
760568003232	MutS domain II; Region: MutS_II; pfam05188
760568003233	MutS domain III; Region: MutS_III; pfam05192
760568003234	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
760568003235	Walker A/P-loop; other site
760568003236	ATP binding site [chemical binding]; other site
760568003237	Q-loop/lid; other site
760568003238	ABC transporter signature motif; other site
760568003239	Walker B; other site
760568003240	D-loop; other site
760568003241	H-loop/switch region; other site
760568003242	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
760568003243	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
760568003244	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
760568003245	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
760568003246	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
760568003247	active site
760568003248	Zn binding site [ion binding]; other site
760568003249	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
760568003250	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568003251	ATP binding site [chemical binding]; other site
760568003252	Mg2+ binding site [ion binding]; other site
760568003253	G-X-G motif; other site
760568003254	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
760568003255	ATP binding site [chemical binding]; other site
760568003256	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
760568003257	Brix domain; Region: Brix; cl00935
760568003258	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
760568003259	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
760568003260	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
760568003261	bacterial Hfq-like; Region: Hfq; cd01716
760568003262	hexamer interface [polypeptide binding]; other site
760568003263	Sm1 motif; other site
760568003264	RNA binding site [nucleotide binding]; other site
760568003265	Sm2 motif; other site
760568003266	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
760568003267	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
760568003268	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
760568003269	putative dimerization interface [polypeptide binding]; other site
760568003270	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
760568003271	Aluminium resistance protein; Region: Alum_res; pfam06838
760568003272	stage V sporulation protein K; Region: spore_V_K; TIGR02881
760568003273	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568003274	Walker A motif; other site
760568003275	ATP binding site [chemical binding]; other site
760568003276	Walker B motif; other site
760568003277	arginine finger; other site
760568003278	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
760568003279	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568003280	putative active site [active]
760568003281	heme pocket [chemical binding]; other site
760568003282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568003283	ATP binding site [chemical binding]; other site
760568003284	G-X-G motif; other site
760568003285	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
760568003286	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568003287	active site
760568003288	phosphorylation site [posttranslational modification]
760568003289	intermolecular recognition site; other site
760568003290	dimerization interface [polypeptide binding]; other site
760568003291	HTH domain; Region: HTH_11; cl17392
760568003292	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
760568003293	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
760568003294	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
760568003295	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
760568003296	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
760568003297	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
760568003298	DctM-like transporters; Region: DctM; pfam06808
760568003299	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
760568003300	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
760568003301	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568003302	Walker A motif; other site
760568003303	ATP binding site [chemical binding]; other site
760568003304	Walker B motif; other site
760568003305	arginine finger; other site
760568003306	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
760568003307	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
760568003308	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
760568003309	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
760568003310	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
760568003311	CoA binding domain; Region: CoA_binding; smart00881
760568003312	CoA-ligase; Region: Ligase_CoA; pfam00549
760568003313	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
760568003314	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
760568003315	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568003316	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
760568003317	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
760568003318	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
760568003319	L-aspartate oxidase; Provisional; Region: PRK06175
760568003320	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
760568003321	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
760568003322	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
760568003323	catalytic loop [active]
760568003324	iron binding site [ion binding]; other site
760568003325	Protein of unknown function (DUF1847); Region: DUF1847; pfam08901
760568003326	LexA repressor; Validated; Region: PRK00215
760568003327	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
760568003328	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
760568003329	Catalytic site [active]
760568003330	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
760568003331	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
760568003332	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568003333	putative active site [active]
760568003334	heme pocket [chemical binding]; other site
760568003335	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568003336	Walker A motif; other site
760568003337	ATP binding site [chemical binding]; other site
760568003338	Walker B motif; other site
760568003339	arginine finger; other site
760568003340	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
760568003341	fumarate hydratase; Provisional; Region: PRK06246
760568003342	Fumarase C-terminus; Region: Fumerase_C; cl00795
760568003343	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
760568003344	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
760568003345	CoA-ligase; Region: Ligase_CoA; pfam00549
760568003346	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
760568003347	CoA binding domain; Region: CoA_binding; pfam02629
760568003348	CoA-ligase; Region: Ligase_CoA; pfam00549
760568003349	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
760568003350	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
760568003351	B12 binding site [chemical binding]; other site
760568003352	cobalt ligand [ion binding]; other site
760568003353	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
760568003354	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
760568003355	dimer interface [polypeptide binding]; other site
760568003356	substrate binding site [chemical binding]; other site
760568003357	metal binding site [ion binding]; metal-binding site
760568003358	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
760568003359	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
760568003360	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
760568003361	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
760568003362	carboxyltransferase (CT) interaction site; other site
760568003363	biotinylation site [posttranslational modification]; other site
760568003364	malate dehydrogenase; Reviewed; Region: PRK06223
760568003365	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
760568003366	NAD(P) binding site [chemical binding]; other site
760568003367	dimer interface [polypeptide binding]; other site
760568003368	tetramer (dimer of dimers) interface [polypeptide binding]; other site
760568003369	substrate binding site [chemical binding]; other site
760568003370	oxaloacetate decarboxylase; Provisional; Region: PRK12331
760568003371	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
760568003372	active site
760568003373	catalytic residues [active]
760568003374	metal binding site [ion binding]; metal-binding site
760568003375	homodimer binding site [polypeptide binding]; other site
760568003376	PBP superfamily domain; Region: PBP_like_2; cl17296
760568003377	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
760568003378	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
760568003379	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
760568003380	dimer interface [polypeptide binding]; other site
760568003381	conserved gate region; other site
760568003382	putative PBP binding loops; other site
760568003383	ABC-ATPase subunit interface; other site
760568003384	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
760568003385	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
760568003386	dimer interface [polypeptide binding]; other site
760568003387	conserved gate region; other site
760568003388	putative PBP binding loops; other site
760568003389	ABC-ATPase subunit interface; other site
760568003390	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
760568003391	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
760568003392	Zn binding site [ion binding]; other site
760568003393	Protein of unknown function (DUF503); Region: DUF503; pfam04456
760568003394	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
760568003395	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
760568003396	active site
760568003397	metal binding site [ion binding]; metal-binding site
760568003398	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
760568003399	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
760568003400	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
760568003401	Walker A/P-loop; other site
760568003402	ATP binding site [chemical binding]; other site
760568003403	Q-loop/lid; other site
760568003404	ABC transporter signature motif; other site
760568003405	Walker B; other site
760568003406	D-loop; other site
760568003407	H-loop/switch region; other site
760568003408	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
760568003409	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
760568003410	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
760568003411	dimer interface [polypeptide binding]; other site
760568003412	conserved gate region; other site
760568003413	ABC-ATPase subunit interface; other site
760568003414	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
760568003415	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
760568003416	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
760568003417	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
760568003418	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
760568003419	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
760568003420	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
760568003421	TrkA-C domain; Region: TrkA_C; pfam02080
760568003422	hypothetical protein; Provisional; Region: PRK04164
760568003423	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
760568003424	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
760568003425	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
760568003426	putative ADP-binding pocket [chemical binding]; other site
760568003427	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
760568003428	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568003429	FeS/SAM binding site; other site
760568003430	Late competence development protein ComFB; Region: ComFB; pfam10719
760568003431	Soluble P-type ATPase [General function prediction only]; Region: COG4087
760568003432	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
760568003433	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
760568003434	active site
760568003435	ADP/pyrophosphate binding site [chemical binding]; other site
760568003436	dimerization interface [polypeptide binding]; other site
760568003437	allosteric effector site; other site
760568003438	fructose-1,6-bisphosphate binding site; other site
760568003439	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
760568003440	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
760568003441	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
760568003442	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
760568003443	Uncharacterized conserved protein [Function unknown]; Region: COG1615
760568003444	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
760568003445	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
760568003446	nucleotide binding site/active site [active]
760568003447	HIT family signature motif; other site
760568003448	catalytic residue [active]
760568003449	Helix-turn-helix domain; Region: HTH_28; pfam13518
760568003450	Winged helix-turn helix; Region: HTH_29; pfam13551
760568003451	Homeodomain-like domain; Region: HTH_32; pfam13565
760568003452	Integrase core domain; Region: rve; pfam00665
760568003453	Integrase core domain; Region: rve_3; cl15866
760568003454	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
760568003455	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
760568003456	Int/Topo IB signature motif; other site
760568003457	Helix-turn-helix domain; Region: HTH_28; pfam13518
760568003458	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
760568003459	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568003460	non-specific DNA binding site [nucleotide binding]; other site
760568003461	salt bridge; other site
760568003462	sequence-specific DNA binding site [nucleotide binding]; other site
760568003463	Helix-turn-helix domain; Region: HTH_17; pfam12728
760568003464	CHC2 zinc finger; Region: zf-CHC2; cl17510
760568003465	hypothetical protein; Provisional; Region: PRK14709
760568003466	D5 N terminal like; Region: D5_N; smart00885
760568003467	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
760568003468	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
760568003469	putative active site [active]
760568003470	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
760568003471	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
760568003472	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
760568003473	YcfA-like protein; Region: YcfA; pfam07927
760568003474	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
760568003475	elongation factor G; Reviewed; Region: PRK12740
760568003476	G1 box; other site
760568003477	putative GEF interaction site [polypeptide binding]; other site
760568003478	GTP/Mg2+ binding site [chemical binding]; other site
760568003479	Switch I region; other site
760568003480	G2 box; other site
760568003481	G3 box; other site
760568003482	Switch II region; other site
760568003483	G4 box; other site
760568003484	G5 box; other site
760568003485	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
760568003486	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
760568003487	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
760568003488	stage V sporulation protein B; Region: spore_V_B; TIGR02900
760568003489	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
760568003490	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
760568003491	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
760568003492	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
760568003493	homodecamer interface [polypeptide binding]; other site
760568003494	GTP cyclohydrolase I; Provisional; Region: PLN03044
760568003495	active site
760568003496	putative catalytic site residues [active]
760568003497	zinc binding site [ion binding]; other site
760568003498	GTP-CH-I/GFRP interaction surface; other site
760568003499	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
760568003500	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568003501	FeS/SAM binding site; other site
760568003502	Domain of unknown function (DUF366); Region: DUF366; pfam04017
760568003503	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
760568003504	Ligand Binding Site [chemical binding]; other site
760568003505	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
760568003506	active site
760568003507	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
760568003508	binding surface
760568003509	TPR repeat; Region: TPR_11; pfam13414
760568003510	TPR motif; other site
760568003511	TPR repeat; Region: TPR_11; pfam13414
760568003512	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
760568003513	binding surface
760568003514	TPR motif; other site
760568003515	TPR repeat; Region: TPR_11; pfam13414
760568003516	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
760568003517	binding surface
760568003518	TPR motif; other site
760568003519	Tetratricopeptide repeat; Region: TPR_16; pfam13432
760568003520	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
760568003521	metal-binding site [ion binding]
760568003522	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
760568003523	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568003524	FeS/SAM binding site; other site
760568003525	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
760568003526	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
760568003527	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
760568003528	FAD binding pocket [chemical binding]; other site
760568003529	FAD binding motif [chemical binding]; other site
760568003530	phosphate binding motif [ion binding]; other site
760568003531	beta-alpha-beta structure motif; other site
760568003532	NAD binding pocket [chemical binding]; other site
760568003533	Iron coordination center [ion binding]; other site
760568003534	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
760568003535	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
760568003536	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
760568003537	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568003538	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
760568003539	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
760568003540	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
760568003541	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
760568003542	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
760568003543	Cysteine-rich domain; Region: CCG; pfam02754
760568003544	Cysteine-rich domain; Region: CCG; pfam02754
760568003545	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568003546	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
760568003547	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
760568003548	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
760568003549	active site
760568003550	catalytic site [active]
760568003551	substrate binding site [chemical binding]; other site
760568003552	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
760568003553	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
760568003554	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
760568003555	active site
760568003556	catalytic residues [active]
760568003557	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
760568003558	metal-dependent hydrolase; Provisional; Region: PRK00685
760568003559	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
760568003560	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
760568003561	Walker A; other site
760568003562	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
760568003563	Switch II region; other site
760568003564	G4 box; other site
760568003565	G5 box; other site
760568003566	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
760568003567	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
760568003568	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
760568003569	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
760568003570	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
760568003571	Walker A/P-loop; other site
760568003572	ATP binding site [chemical binding]; other site
760568003573	Q-loop/lid; other site
760568003574	ABC transporter signature motif; other site
760568003575	Walker B; other site
760568003576	D-loop; other site
760568003577	H-loop/switch region; other site
760568003578	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
760568003579	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
760568003580	Walker A/P-loop; other site
760568003581	ATP binding site [chemical binding]; other site
760568003582	Q-loop/lid; other site
760568003583	ABC transporter signature motif; other site
760568003584	Walker B; other site
760568003585	D-loop; other site
760568003586	H-loop/switch region; other site
760568003587	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
760568003588	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
760568003589	TM-ABC transporter signature motif; other site
760568003590	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
760568003591	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
760568003592	TM-ABC transporter signature motif; other site
760568003593	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
760568003594	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
760568003595	putative ligand binding site [chemical binding]; other site
760568003596	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
760568003597	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568003598	S-adenosylmethionine binding site [chemical binding]; other site
760568003599	adenylate kinase; Reviewed; Region: adk; PRK00279
760568003600	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
760568003601	AMP-binding site [chemical binding]; other site
760568003602	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
760568003603	Domain of unknown function (DUF3786); Region: DUF3786; pfam12654
760568003604	Transglycosylase; Region: Transgly; pfam00912
760568003605	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
760568003606	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
760568003607	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
760568003608	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
760568003609	Asp23 family; Region: Asp23; pfam03780
760568003610	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
760568003611	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
760568003612	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
760568003613	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
760568003614	Precorrin-8X methylmutase; Region: CbiC; pfam02570
760568003615	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
760568003616	putative active site [active]
760568003617	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
760568003618	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
760568003619	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
760568003620	active site
760568003621	SAM binding site [chemical binding]; other site
760568003622	homodimer interface [polypeptide binding]; other site
760568003623	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
760568003624	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
760568003625	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
760568003626	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
760568003627	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
760568003628	active site
760568003629	SAM binding site [chemical binding]; other site
760568003630	homodimer interface [polypeptide binding]; other site
760568003631	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
760568003632	active site
760568003633	SAM binding site [chemical binding]; other site
760568003634	homodimer interface [polypeptide binding]; other site
760568003635	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
760568003636	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568003637	S-adenosylmethionine binding site [chemical binding]; other site
760568003638	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
760568003639	active site
760568003640	putative homodimer interface [polypeptide binding]; other site
760568003641	SAM binding site [chemical binding]; other site
760568003642	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
760568003643	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568003644	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
760568003645	Walker A motif; other site
760568003646	ATP binding site [chemical binding]; other site
760568003647	Walker B motif; other site
760568003648	arginine finger; other site
760568003649	Helix-turn-helix domain; Region: HTH_36; pfam13730
760568003650	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
760568003651	histidinol-phosphatase; Provisional; Region: PRK07328
760568003652	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
760568003653	active site
760568003654	dimer interface [polypeptide binding]; other site
760568003655	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
760568003656	Isochorismatase family; Region: Isochorismatase; pfam00857
760568003657	catalytic triad [active]
760568003658	conserved cis-peptide bond; other site
760568003659	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
760568003660	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
760568003661	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
760568003662	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
760568003663	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
760568003664	FAD binding site [chemical binding]; other site
760568003665	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
760568003666	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
760568003667	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
760568003668	4Fe-4S binding domain; Region: Fer4; pfam00037
760568003669	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
760568003670	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
760568003671	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
760568003672	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
760568003673	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
760568003674	Cysteine-rich domain; Region: CCG; pfam02754
760568003675	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
760568003676	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
760568003677	FAD binding pocket [chemical binding]; other site
760568003678	FAD binding motif [chemical binding]; other site
760568003679	phosphate binding motif [ion binding]; other site
760568003680	beta-alpha-beta structure motif; other site
760568003681	NAD binding pocket [chemical binding]; other site
760568003682	Iron coordination center [ion binding]; other site
760568003683	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
760568003684	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
760568003685	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
760568003686	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
760568003687	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
760568003688	Cysteine-rich domain; Region: CCG; pfam02754
760568003689	Cysteine-rich domain; Region: CCG; pfam02754
760568003690	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568003691	CoB--CoM heterodisulfide reductase, subunit C; Region: CoB_CoM_SS_C; TIGR03290
760568003692	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
760568003693	4Fe-4S binding domain; Region: Fer4; pfam00037
760568003694	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
760568003695	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
760568003696	substrate binding pocket [chemical binding]; other site
760568003697	dimer interface [polypeptide binding]; other site
760568003698	inhibitor binding site; inhibition site
760568003699	acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452
760568003700	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
760568003701	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
760568003702	acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165
760568003703	Putative Fe-S cluster; Region: FeS; cl17515
760568003704	bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529
760568003705	Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA.  ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH)...; Region: ACS_2; cd01917
760568003706	CODH interaction site; other site
760568003707	CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598
760568003708	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
760568003709	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
760568003710	ACS interaction site; other site
760568003711	CODH interaction site; other site
760568003712	cubane metal cluster (B-cluster) [ion binding]; other site
760568003713	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
760568003714	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
760568003715	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
760568003716	P-loop; other site
760568003717	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
760568003718	Uncharacterized conserved protein [Function unknown]; Region: COG3937
760568003719	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
760568003720	4Fe-4S binding domain; Region: Fer4; cl02805
760568003721	hypothetical protein; Reviewed; Region: PRK09588
760568003722	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
760568003723	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
760568003724	L-aspartate oxidase; Provisional; Region: PRK06175
760568003725	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
760568003726	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568003727	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
760568003728	Cysteine-rich domain; Region: CCG; pfam02754
760568003729	Cysteine-rich domain; Region: CCG; pfam02754
760568003730	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568003731	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
760568003732	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
760568003733	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
760568003734	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
760568003735	MoxR-like ATPases [General function prediction only]; Region: COG0714
760568003736	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568003737	Walker A motif; other site
760568003738	ATP binding site [chemical binding]; other site
760568003739	Walker B motif; other site
760568003740	arginine finger; other site
760568003741	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
760568003742	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
760568003743	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
760568003744	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
760568003745	CoA binding domain; Region: CoA_binding; smart00881
760568003746	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
760568003747	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
760568003748	inhibitor-cofactor binding pocket; inhibition site
760568003749	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568003750	catalytic residue [active]
760568003751	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
760568003752	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
760568003753	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
760568003754	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
760568003755	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568003756	FeS/SAM binding site; other site
760568003757	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
760568003758	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
760568003759	dimer interface [polypeptide binding]; other site
760568003760	active site
760568003761	Schiff base residues; other site
760568003762	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
760568003763	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568003764	FeS/SAM binding site; other site
760568003765	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
760568003766	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
760568003767	active site
760568003768	SAM binding site [chemical binding]; other site
760568003769	homodimer interface [polypeptide binding]; other site
760568003770	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
760568003771	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
760568003772	active site
760568003773	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
760568003774	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
760568003775	domain interfaces; other site
760568003776	active site
760568003777	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
760568003778	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
760568003779	tRNA; other site
760568003780	putative tRNA binding site [nucleotide binding]; other site
760568003781	putative NADP binding site [chemical binding]; other site
760568003782	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
760568003783	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
760568003784	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
760568003785	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
760568003786	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
760568003787	substrate binding pocket [chemical binding]; other site
760568003788	chain length determination region; other site
760568003789	substrate-Mg2+ binding site; other site
760568003790	catalytic residues [active]
760568003791	aspartate-rich region 1; other site
760568003792	active site lid residues [active]
760568003793	aspartate-rich region 2; other site
760568003794	Spore germination protein; Region: Spore_permease; cl17796
760568003795	Restriction endonuclease; Region: Mrr_cat; pfam04471
760568003796	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
760568003797	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
760568003798	putative dimer interface [polypeptide binding]; other site
760568003799	[2Fe-2S] cluster binding site [ion binding]; other site
760568003800	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
760568003801	dimer interface [polypeptide binding]; other site
760568003802	[2Fe-2S] cluster binding site [ion binding]; other site
760568003803	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
760568003804	SLBB domain; Region: SLBB; pfam10531
760568003805	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
760568003806	4Fe-4S binding domain; Region: Fer4; pfam00037
760568003807	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
760568003808	Flagellin N-methylase; Region: FliB; pfam03692
760568003809	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
760568003810	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585
760568003811	putative active site [active]
760568003812	catalytic triad [active]
760568003813	putative dimer interface [polypeptide binding]; other site
760568003814	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
760568003815	TPP-binding site [chemical binding]; other site
760568003816	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
760568003817	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
760568003818	Coenzyme A binding pocket [chemical binding]; other site
760568003819	CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507
760568003820	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
760568003821	putative active site [active]
760568003822	catalytic triad [active]
760568003823	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
760568003824	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
760568003825	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
760568003826	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
760568003827	dimerization interface [polypeptide binding]; other site
760568003828	ATP binding site [chemical binding]; other site
760568003829	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
760568003830	dimerization interface [polypeptide binding]; other site
760568003831	ATP binding site [chemical binding]; other site
760568003832	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
760568003833	Ligand Binding Site [chemical binding]; other site
760568003834	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
760568003835	RNA/DNA hybrid binding site [nucleotide binding]; other site
760568003836	active site
760568003837	Protein of unknown function (DUF456); Region: DUF456; pfam04306
760568003838	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
760568003839	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
760568003840	G1 box; other site
760568003841	GTP/Mg2+ binding site [chemical binding]; other site
760568003842	Switch I region; other site
760568003843	G2 box; other site
760568003844	G3 box; other site
760568003845	Switch II region; other site
760568003846	G4 box; other site
760568003847	G5 box; other site
760568003848	Nucleoside recognition; Region: Gate; pfam07670
760568003849	Nucleoside recognition; Region: Gate; pfam07670
760568003850	FeoA domain; Region: FeoA; pfam04023
760568003851	Uncharacterized conserved protein [Function unknown]; Region: COG1565
760568003852	Protein of unknown function (DUF1657); Region: DUF1657; pfam07870
760568003853	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
760568003854	trimer interface [polypeptide binding]; other site
760568003855	putative Zn binding site [ion binding]; other site
760568003856	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
760568003857	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
760568003858	G1 box; other site
760568003859	putative GEF interaction site [polypeptide binding]; other site
760568003860	GTP/Mg2+ binding site [chemical binding]; other site
760568003861	Switch I region; other site
760568003862	G2 box; other site
760568003863	G3 box; other site
760568003864	Switch II region; other site
760568003865	G4 box; other site
760568003866	G5 box; other site
760568003867	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
760568003868	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
760568003869	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
760568003870	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
760568003871	selenocysteine synthase; Provisional; Region: PRK04311
760568003872	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
760568003873	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
760568003874	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
760568003875	catalytic residue [active]
760568003876	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
760568003877	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568003878	FeS/SAM binding site; other site
760568003879	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
760568003880	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
760568003881	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568003882	FeS/SAM binding site; other site
760568003883	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
760568003884	UbiA prenyltransferase family; Region: UbiA; pfam01040
760568003885	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
760568003886	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
760568003887	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568003888	S-adenosylmethionine binding site [chemical binding]; other site
760568003889	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
760568003890	substrate binding pocket [chemical binding]; other site
760568003891	aspartate-rich region 1; other site
760568003892	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
760568003893	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
760568003894	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
760568003895	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
760568003896	putative ADP-binding pocket [chemical binding]; other site
760568003897	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
760568003898	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
760568003899	FG-GAP repeat; Region: FG-GAP; pfam01839
760568003900	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
760568003901	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
760568003902	CHASE3 domain; Region: CHASE3; pfam05227
760568003903	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
760568003904	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
760568003905	dimerization interface [polypeptide binding]; other site
760568003906	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
760568003907	dimer interface [polypeptide binding]; other site
760568003908	putative CheW interface [polypeptide binding]; other site
760568003909	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
760568003910	putative CheW interface [polypeptide binding]; other site
760568003911	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
760568003912	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
760568003913	Int/Topo IB signature motif; other site
760568003914	Helix-turn-helix domain; Region: HTH_17; pfam12728
760568003915	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
760568003916	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
760568003917	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
760568003918	active site
760568003919	ATP binding site [chemical binding]; other site
760568003920	substrate binding site [chemical binding]; other site
760568003921	activation loop (A-loop); other site
760568003922	Protein phosphatase 2C; Region: PP2C_2; pfam13672
760568003923	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
760568003924	metal ion-dependent adhesion site (MIDAS); other site
760568003925	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
760568003926	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
760568003927	active site
760568003928	DNA binding site [nucleotide binding]
760568003929	Int/Topo IB signature motif; other site
760568003930	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
760568003931	ADP-ribose binding site [chemical binding]; other site
760568003932	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
760568003933	DNA topoisomerase VI, subunit B [DNA replication, recombination, and repair]; Region: COG1389
760568003934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568003935	Mg2+ binding site [ion binding]; other site
760568003936	G-X-G motif; other site
760568003937	DNA topoisomerase VI, subunit A [DNA replication, recombination, and repair]; Region: COG1697
760568003938	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
760568003939	active site
760568003940	metal binding site [ion binding]; metal-binding site
760568003941	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
760568003942	Protein of unknown function (DUF497); Region: DUF497; cl01108
760568003943	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222
760568003944	RNA/DNA hybrid binding site [nucleotide binding]; other site
760568003945	active site
760568003946	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
760568003947	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
760568003948	Zn binding site [ion binding]; other site
760568003949	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
760568003950	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
760568003951	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
760568003952	IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330
760568003953	PemK-like protein; Region: PemK; pfam02452
760568003954	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
760568003955	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
760568003956	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
760568003957	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
760568003958	Walker A motif; other site
760568003959	ATP binding site [chemical binding]; other site
760568003960	Walker B motif; other site
760568003961	ribbon-helix-helix domain containing protein; Region: PHA00617
760568003962	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
760568003963	IHF dimer interface [polypeptide binding]; other site
760568003964	IHF - DNA interface [nucleotide binding]; other site
760568003965	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
760568003966	PRTRC system protein D; Region: PRTRC_D; TIGR03739
760568003967	Mg binding site [ion binding]; other site
760568003968	nucleotide binding site [chemical binding]; other site
760568003969	putative protofilament interface [polypeptide binding]; other site
760568003970	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
760568003971	IHF - DNA interface [nucleotide binding]; other site
760568003972	IHF dimer interface [polypeptide binding]; other site
760568003973	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568003974	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
760568003975	Protein of unknown function (DUF3832); Region: DUF3832; pfam12909
760568003976	CHC2 zinc finger; Region: zf-CHC2; cl17510
760568003977	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
760568003978	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
760568003979	active site
760568003980	metal binding site [ion binding]; metal-binding site
760568003981	interdomain interaction site; other site
760568003982	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
760568003983	Walker A motif; other site
760568003984	ATP binding site [chemical binding]; other site
760568003985	Walker B motif; other site
760568003986	Protein of unknown function (DUF497); Region: DUF497; cl01108
760568003987	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
760568003988	Predicted transcriptional regulator [Transcription]; Region: COG2944
760568003989	Protein of unknown function (DUF3795); Region: DUF3795; pfam12675
760568003990	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
760568003991	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
760568003992	substrate binding site [chemical binding]; other site
760568003993	ATP binding site [chemical binding]; other site
760568003994	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
760568003995	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
760568003996	active site
760568003997	intersubunit interface [polypeptide binding]; other site
760568003998	catalytic residue [active]
760568003999	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
760568004000	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
760568004001	Metal-binding active site; metal-binding site
760568004002	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
760568004003	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
760568004004	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
760568004005	putative NAD(P) binding site [chemical binding]; other site
760568004006	catalytic Zn binding site [ion binding]; other site
760568004007	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
760568004008	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
760568004009	NAD(P) binding site [chemical binding]; other site
760568004010	Transcriptional regulators [Transcription]; Region: PurR; COG1609
760568004011	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
760568004012	DNA binding site [nucleotide binding]
760568004013	domain linker motif; other site
760568004014	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
760568004015	dimerization interface [polypeptide binding]; other site
760568004016	ligand binding site [chemical binding]; other site
760568004017	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
760568004018	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
760568004019	ligand binding site [chemical binding]; other site
760568004020	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
760568004021	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
760568004022	TM-ABC transporter signature motif; other site
760568004023	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
760568004024	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
760568004025	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
760568004026	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
760568004027	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
760568004028	Walker A/P-loop; other site
760568004029	ATP binding site [chemical binding]; other site
760568004030	Q-loop/lid; other site
760568004031	ABC transporter signature motif; other site
760568004032	Walker B; other site
760568004033	D-loop; other site
760568004034	H-loop/switch region; other site
760568004035	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
760568004036	Transcriptional regulators [Transcription]; Region: PurR; COG1609
760568004037	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
760568004038	DNA binding site [nucleotide binding]
760568004039	domain linker motif; other site
760568004040	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
760568004041	ligand binding site [chemical binding]; other site
760568004042	dimerization interface [polypeptide binding]; other site
760568004043	altronate oxidoreductase; Provisional; Region: PRK03643
760568004044	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
760568004045	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
760568004046	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
760568004047	galactarate dehydratase; Region: galactar-dH20; TIGR03248
760568004048	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
760568004049	sporulation sigma factor SigK; Reviewed; Region: PRK05803
760568004050	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
760568004051	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
760568004052	DNA binding residues [nucleotide binding]
760568004053	Domain of unknown function DUF39; Region: DUF39; pfam01837
760568004054	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
760568004055	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
760568004056	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568004057	hypothetical protein; Provisional; Region: PRK04334
760568004058	acyl-CoA synthetase; Validated; Region: PRK08162
760568004059	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
760568004060	acyl-activating enzyme (AAE) consensus motif; other site
760568004061	putative active site [active]
760568004062	AMP binding site [chemical binding]; other site
760568004063	putative CoA binding site [chemical binding]; other site
760568004064	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
760568004065	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
760568004066	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568004067	Zn2+ binding site [ion binding]; other site
760568004068	Mg2+ binding site [ion binding]; other site
760568004069	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
760568004070	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
760568004071	pyruvate kinase; Provisional; Region: PRK06354
760568004072	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
760568004073	domain interfaces; other site
760568004074	active site
760568004075	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
760568004076	6-phosphofructokinase; Provisional; Region: PRK03202
760568004077	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
760568004078	active site
760568004079	ADP/pyrophosphate binding site [chemical binding]; other site
760568004080	dimerization interface [polypeptide binding]; other site
760568004081	allosteric effector site; other site
760568004082	fructose-1,6-bisphosphate binding site; other site
760568004083	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
760568004084	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
760568004085	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
760568004086	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
760568004087	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
760568004088	transcription attenuation protein MtrB; Provisional; Region: PRK13251
760568004089	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
760568004090	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
760568004091	active site
760568004092	PHP Thumb interface [polypeptide binding]; other site
760568004093	metal binding site [ion binding]; metal-binding site
760568004094	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
760568004095	generic binding surface II; other site
760568004096	generic binding surface I; other site
760568004097	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
760568004098	metal binding site 2 [ion binding]; metal-binding site
760568004099	putative DNA binding helix; other site
760568004100	metal binding site 1 [ion binding]; metal-binding site
760568004101	dimer interface [polypeptide binding]; other site
760568004102	structural Zn2+ binding site [ion binding]; other site
760568004103	ribulose-1,5-biphosphate synthetase; Provisional; Region: PRK04176
760568004104	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
760568004105	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568004106	putative active site [active]
760568004107	heme pocket [chemical binding]; other site
760568004108	PAS domain; Region: PAS; smart00091
760568004109	putative active site [active]
760568004110	heme pocket [chemical binding]; other site
760568004111	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568004112	Walker A motif; other site
760568004113	ATP binding site [chemical binding]; other site
760568004114	Walker B motif; other site
760568004115	arginine finger; other site
760568004116	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
760568004117	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
760568004118	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
760568004119	MoxR-like ATPases [General function prediction only]; Region: COG0714
760568004120	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568004121	Walker A motif; other site
760568004122	ATP binding site [chemical binding]; other site
760568004123	Walker B motif; other site
760568004124	arginine finger; other site
760568004125	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
760568004126	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
760568004127	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
760568004128	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
760568004129	minor groove reading motif; other site
760568004130	helix-hairpin-helix signature motif; other site
760568004131	substrate binding pocket [chemical binding]; other site
760568004132	active site
760568004133	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
760568004134	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
760568004135	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
760568004136	Uncharacterized conserved protein [Function unknown]; Region: COG1543
760568004137	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
760568004138	active site
760568004139	substrate binding site [chemical binding]; other site
760568004140	catalytic site [active]
760568004141	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
760568004142	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
760568004143	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
760568004144	active site
760568004145	Substrate binding site; other site
760568004146	Mg++ binding site; other site
760568004147	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
760568004148	putative trimer interface [polypeptide binding]; other site
760568004149	putative CoA binding site [chemical binding]; other site
760568004150	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
760568004151	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
760568004152	active site
760568004153	substrate binding site [chemical binding]; other site
760568004154	metal binding site [ion binding]; metal-binding site
760568004155	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
760568004156	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
760568004157	Carbohydrate binding domain; Region: CBM_25; smart01066
760568004158	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
760568004159	isocitrate dehydrogenase; Validated; Region: PRK06451
760568004160	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
760568004161	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
760568004162	substrate binding site [chemical binding]; other site
760568004163	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
760568004164	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
760568004165	substrate binding site [chemical binding]; other site
760568004166	ligand binding site [chemical binding]; other site
760568004167	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
760568004168	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
760568004169	active site
760568004170	catalytic residues [active]
760568004171	metal binding site [ion binding]; metal-binding site
760568004172	Major Facilitator Superfamily; Region: MFS_1; pfam07690
760568004173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568004174	putative substrate translocation pore; other site
760568004175	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
760568004176	HEAT repeats; Region: HEAT_2; pfam13646
760568004177	protein binding surface [polypeptide binding]; other site
760568004178	HEAT repeats; Region: HEAT_2; pfam13646
760568004179	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
760568004180	HEAT repeats; Region: HEAT_2; pfam13646
760568004181	protein binding surface [polypeptide binding]; other site
760568004182	HEAT repeats; Region: HEAT_2; pfam13646
760568004183	HEAT repeats; Region: HEAT_2; pfam13646
760568004184	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
760568004185	HEAT repeats; Region: HEAT_2; pfam13646
760568004186	HEAT repeats; Region: HEAT_2; pfam13646
760568004187	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
760568004188	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
760568004189	GatB domain; Region: GatB_Yqey; smart00845
760568004190	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
760568004191	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
760568004192	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
760568004193	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
760568004194	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
760568004195	nucleotide binding pocket [chemical binding]; other site
760568004196	K-X-D-G motif; other site
760568004197	catalytic site [active]
760568004198	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
760568004199	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
760568004200	Helix-hairpin-helix motif; Region: HHH; pfam00633
760568004201	helix-hairpin-helix signature motif; other site
760568004202	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
760568004203	Dimer interface [polypeptide binding]; other site
760568004204	BRCT sequence motif; other site
760568004205	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
760568004206	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
760568004207	Part of AAA domain; Region: AAA_19; pfam13245
760568004208	Family description; Region: UvrD_C_2; pfam13538
760568004209	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
760568004210	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
760568004211	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
760568004212	metal binding site [ion binding]; metal-binding site
760568004213	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
760568004214	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
760568004215	substrate binding site [chemical binding]; other site
760568004216	glutamase interaction surface [polypeptide binding]; other site
760568004217	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
760568004218	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
760568004219	catalytic residues [active]
760568004220	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
760568004221	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
760568004222	putative active site [active]
760568004223	oxyanion strand; other site
760568004224	catalytic triad [active]
760568004225	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
760568004226	putative active site pocket [active]
760568004227	4-fold oligomerization interface [polypeptide binding]; other site
760568004228	metal binding residues [ion binding]; metal-binding site
760568004229	3-fold/trimer interface [polypeptide binding]; other site
760568004230	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
760568004231	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
760568004232	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568004233	homodimer interface [polypeptide binding]; other site
760568004234	catalytic residue [active]
760568004235	histidinol dehydrogenase; Region: hisD; TIGR00069
760568004236	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
760568004237	NAD binding site [chemical binding]; other site
760568004238	dimerization interface [polypeptide binding]; other site
760568004239	product binding site; other site
760568004240	substrate binding site [chemical binding]; other site
760568004241	zinc binding site [ion binding]; other site
760568004242	catalytic residues [active]
760568004243	Trp repressor protein; Region: Trp_repressor; cl17266
760568004244	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
760568004245	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
760568004246	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
760568004247	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
760568004248	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
760568004249	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
760568004250	purine monophosphate binding site [chemical binding]; other site
760568004251	dimer interface [polypeptide binding]; other site
760568004252	putative catalytic residues [active]
760568004253	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
760568004254	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
760568004255	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
760568004256	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
760568004257	active site
760568004258	substrate binding site [chemical binding]; other site
760568004259	cosubstrate binding site; other site
760568004260	catalytic site [active]
760568004261	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
760568004262	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
760568004263	dimerization interface [polypeptide binding]; other site
760568004264	putative ATP binding site [chemical binding]; other site
760568004265	amidophosphoribosyltransferase; Provisional; Region: PRK05793
760568004266	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
760568004267	active site
760568004268	tetramer interface [polypeptide binding]; other site
760568004269	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
760568004270	active site
760568004271	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
760568004272	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
760568004273	ATP binding site [chemical binding]; other site
760568004274	active site
760568004275	substrate binding site [chemical binding]; other site
760568004276	adenylosuccinate lyase; Provisional; Region: PRK07492
760568004277	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
760568004278	tetramer interface [polypeptide binding]; other site
760568004279	active site
760568004280	AIR carboxylase; Region: AIRC; pfam00731
760568004281	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
760568004282	GMP synthase; Reviewed; Region: guaA; PRK00074
760568004283	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
760568004284	AMP/PPi binding site [chemical binding]; other site
760568004285	candidate oxyanion hole; other site
760568004286	catalytic triad [active]
760568004287	potential glutamine specificity residues [chemical binding]; other site
760568004288	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
760568004289	ATP Binding subdomain [chemical binding]; other site
760568004290	Ligand Binding sites [chemical binding]; other site
760568004291	Dimerization subdomain; other site
760568004292	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
760568004293	active site
760568004294	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
760568004295	homodimer interface [polypeptide binding]; other site
760568004296	metal binding site [ion binding]; metal-binding site
760568004297	Uncharacterized conserved protein [Function unknown]; Region: COG4198
760568004298	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
760568004299	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
760568004300	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
760568004301	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568004302	active site
760568004303	NTP binding site [chemical binding]; other site
760568004304	metal binding triad [ion binding]; metal-binding site
760568004305	antibiotic binding site [chemical binding]; other site
760568004306	Tetratricopeptide repeat; Region: TPR_16; pfam13432
760568004307	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
760568004308	TPR motif; other site
760568004309	binding surface
760568004310	S-layer homology domain; Region: SLH; pfam00395
760568004311	S-layer homology domain; Region: SLH; pfam00395
760568004312	PQQ-like domain; Region: PQQ_2; pfam13360
760568004313	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
760568004314	active site
760568004315	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
760568004316	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
760568004317	putative active site [active]
760568004318	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
760568004319	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
760568004320	Substrate binding site; other site
760568004321	Cupin domain; Region: Cupin_2; cl17218
760568004322	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
760568004323	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
760568004324	Transposase [DNA replication, recombination, and repair]; Region: COG5421
760568004325	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
760568004326	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
760568004327	NAD(P) binding site [chemical binding]; other site
760568004328	homodimer interface [polypeptide binding]; other site
760568004329	substrate binding site [chemical binding]; other site
760568004330	active site
760568004331	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
760568004332	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
760568004333	inhibitor-cofactor binding pocket; inhibition site
760568004334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568004335	catalytic residue [active]
760568004336	HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7
760568004337	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
760568004338	motif II; other site
760568004339	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
760568004340	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
760568004341	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
760568004342	Bacterial sugar transferase; Region: Bac_transf; pfam02397
760568004343	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
760568004344	active site
760568004345	catalytic triad [active]
760568004346	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
760568004347	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568004348	Walker A motif; other site
760568004349	ATP binding site [chemical binding]; other site
760568004350	Walker B motif; other site
760568004351	arginine finger; other site
760568004352	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
760568004353	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
760568004354	putative ADP-binding pocket [chemical binding]; other site
760568004355	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
760568004356	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
760568004357	putative ADP-binding pocket [chemical binding]; other site
760568004358	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
760568004359	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
760568004360	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
760568004361	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
760568004362	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
760568004363	active site
760568004364	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
760568004365	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
760568004366	NAD(P) binding site [chemical binding]; other site
760568004367	active site
760568004368	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
760568004369	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
760568004370	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
760568004371	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
760568004372	Chain length determinant protein; Region: Wzz; pfam02706
760568004373	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
760568004374	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
760568004375	binding surface
760568004376	TPR motif; other site
760568004377	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
760568004378	flagellar motor switch protein; Validated; Region: PRK08119
760568004379	CheC-like family; Region: CheC; pfam04509
760568004380	CheC-like family; Region: CheC; pfam04509
760568004381	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
760568004382	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
760568004383	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
760568004384	Response regulator receiver domain; Region: Response_reg; pfam00072
760568004385	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568004386	active site
760568004387	phosphorylation site [posttranslational modification]
760568004388	intermolecular recognition site; other site
760568004389	dimerization interface [polypeptide binding]; other site
760568004390	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
760568004391	CheC-like family; Region: CheC; pfam04509
760568004392	CheC-like family; Region: CheC; pfam04509
760568004393	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
760568004394	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
760568004395	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568004396	S-adenosylmethionine binding site [chemical binding]; other site
760568004397	CheD chemotactic sensory transduction; Region: CheD; cl00810
760568004398	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
760568004399	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
760568004400	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
760568004401	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
760568004402	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
760568004403	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
760568004404	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
760568004405	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
760568004406	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
760568004407	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
760568004408	DNA binding residues [nucleotide binding]
760568004409	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
760568004410	Flagellar protein YcgR; Region: YcgR_2; pfam12945
760568004411	PilZ domain; Region: PilZ; pfam07238
760568004412	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
760568004413	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
760568004414	P-loop; other site
760568004415	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
760568004416	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
760568004417	FHIPEP family; Region: FHIPEP; pfam00771
760568004418	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
760568004419	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
760568004420	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
760568004421	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
760568004422	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
760568004423	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
760568004424	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
760568004425	flagellar motor switch protein FliN; Region: fliN; TIGR02480
760568004426	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
760568004427	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636
760568004428	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
760568004429	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
760568004430	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
760568004431	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
760568004432	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
760568004433	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
760568004434	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618
760568004435	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
760568004436	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
760568004437	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
760568004438	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
760568004439	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
760568004440	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
760568004441	Walker A motif/ATP binding site; other site
760568004442	Walker B motif; other site
760568004443	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
760568004444	Flagellar assembly protein FliH; Region: FliH; pfam02108
760568004445	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
760568004446	FliG C-terminal domain; Region: FliG_C; pfam01706
760568004447	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
760568004448	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
760568004449	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
760568004450	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
760568004451	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
760568004452	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
760568004453	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
760568004454	Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815
760568004455	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
760568004456	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
760568004457	inhibitor-cofactor binding pocket; inhibition site
760568004458	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568004459	catalytic residue [active]
760568004460	PIN domain; Region: PIN_3; cl17397
760568004461	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
760568004462	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
760568004463	FlaG protein; Region: FlaG; pfam03646
760568004464	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
760568004465	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
760568004466	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
760568004467	flagellar hook-associated protein FlgL; Validated; Region: PRK06663
760568004468	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
760568004469	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568004470	active site
760568004471	NTP binding site [chemical binding]; other site
760568004472	metal binding triad [ion binding]; metal-binding site
760568004473	antibiotic binding site [chemical binding]; other site
760568004474	Protein of unknown function DUF86; Region: DUF86; pfam01934
760568004475	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
760568004476	putative active site [active]
760568004477	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568004478	active site
760568004479	NTP binding site [chemical binding]; other site
760568004480	metal binding triad [ion binding]; metal-binding site
760568004481	antibiotic binding site [chemical binding]; other site
760568004482	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
760568004483	putative active site [active]
760568004484	LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161
760568004485	Transposase; Region: DEDD_Tnp_IS110; pfam01548
760568004486	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
760568004487	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
760568004488	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
760568004489	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
760568004490	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
760568004491	putative active site [active]
760568004492	putative NTP binding site [chemical binding]; other site
760568004493	putative nucleic acid binding site [nucleotide binding]; other site
760568004494	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
760568004495	flagellin; Reviewed; Region: PRK08869
760568004496	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
760568004497	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
760568004498	Probable transposase; Region: OrfB_IS605; pfam01385
760568004499	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
760568004500	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
760568004501	Global regulator protein family; Region: CsrA; pfam02599
760568004502	FliW protein; Region: FliW; cl00740
760568004503	ssDNA binding protein; Region: Viral_DNA_bp; cl17757
760568004504	flagellar capping protein; Validated; Region: fliD; PRK07737
760568004505	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
760568004506	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
760568004507	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
760568004508	FlaG protein; Region: FlaG; cl00591
760568004509	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568004510	Response regulator receiver domain; Region: Response_reg; pfam00072
760568004511	active site
760568004512	phosphorylation site [posttranslational modification]
760568004513	intermolecular recognition site; other site
760568004514	dimerization interface [polypeptide binding]; other site
760568004515	CheB methylesterase; Region: CheB_methylest; pfam01339
760568004516	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
760568004517	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
760568004518	putative binding surface; other site
760568004519	active site
760568004520	P2 response regulator binding domain; Region: P2; pfam07194
760568004521	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
760568004522	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568004523	ATP binding site [chemical binding]; other site
760568004524	Mg2+ binding site [ion binding]; other site
760568004525	G-X-G motif; other site
760568004526	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
760568004527	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
760568004528	putative CheA interaction surface; other site
760568004529	flagellar motor protein MotA; Validated; Region: PRK08124
760568004530	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
760568004531	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
760568004532	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
760568004533	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
760568004534	ligand binding site [chemical binding]; other site
760568004535	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
760568004536	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
760568004537	dimer interface [polypeptide binding]; other site
760568004538	putative CheW interface [polypeptide binding]; other site
760568004539	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
760568004540	dimerization interface [polypeptide binding]; other site
760568004541	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
760568004542	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
760568004543	dimer interface [polypeptide binding]; other site
760568004544	putative CheW interface [polypeptide binding]; other site
760568004545	2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100
760568004546	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
760568004547	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
760568004548	ABC1 family; Region: ABC1; pfam03109
760568004549	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
760568004550	active site
760568004551	ATP binding site [chemical binding]; other site
760568004552	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
760568004553	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
760568004554	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
760568004555	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
760568004556	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
760568004557	homoserine kinase; Provisional; Region: PRK01212
760568004558	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
760568004559	homoserine dehydrogenase; Provisional; Region: PRK06349
760568004560	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
760568004561	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
760568004562	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
760568004563	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
760568004564	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
760568004565	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
760568004566	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
760568004567	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
760568004568	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
760568004569	NlpC/P60 family; Region: NLPC_P60; pfam00877
760568004570	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
760568004571	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
760568004572	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
760568004573	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
760568004574	GTP-binding protein Der; Reviewed; Region: PRK00093
760568004575	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
760568004576	G1 box; other site
760568004577	GTP/Mg2+ binding site [chemical binding]; other site
760568004578	Switch I region; other site
760568004579	G2 box; other site
760568004580	Switch II region; other site
760568004581	G3 box; other site
760568004582	G4 box; other site
760568004583	G5 box; other site
760568004584	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
760568004585	G1 box; other site
760568004586	GTP/Mg2+ binding site [chemical binding]; other site
760568004587	Switch I region; other site
760568004588	G2 box; other site
760568004589	G3 box; other site
760568004590	Switch II region; other site
760568004591	G4 box; other site
760568004592	G5 box; other site
760568004593	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
760568004594	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
760568004595	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568004596	FeS/SAM binding site; other site
760568004597	Protein of unknown function (DUF512); Region: DUF512; pfam04459
760568004598	YIEGIA protein; Region: YIEGIA; pfam14045
760568004599	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
760568004600	stage II sporulation protein P; Region: spore_II_P; TIGR02867
760568004601	Protein of unknown function (DUF1614); Region: DUF1614; pfam07758
760568004602	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
760568004603	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
760568004604	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
760568004605	RNA binding site [nucleotide binding]; other site
760568004606	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
760568004607	RNA binding site [nucleotide binding]; other site
760568004608	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
760568004609	RNA binding site [nucleotide binding]; other site
760568004610	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
760568004611	RNA binding site [nucleotide binding]; other site
760568004612	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
760568004613	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
760568004614	putative acyl-acceptor binding pocket; other site
760568004615	cytidylate kinase; Provisional; Region: cmk; PRK00023
760568004616	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
760568004617	CMP-binding site; other site
760568004618	The sites determining sugar specificity; other site
760568004619	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
760568004620	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
760568004621	hinge; other site
760568004622	active site
760568004623	prephenate dehydrogenase; Validated; Region: PRK06545
760568004624	prephenate dehydrogenase; Validated; Region: PRK08507
760568004625	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
760568004626	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
760568004627	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
760568004628	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876
760568004629	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
760568004630	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
760568004631	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
760568004632	substrate binding site [chemical binding]; other site
760568004633	active site
760568004634	catalytic residues [active]
760568004635	heterodimer interface [polypeptide binding]; other site
760568004636	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
760568004637	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
760568004638	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568004639	catalytic residue [active]
760568004640	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
760568004641	active site
760568004642	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
760568004643	active site
760568004644	ribulose/triose binding site [chemical binding]; other site
760568004645	phosphate binding site [ion binding]; other site
760568004646	substrate (anthranilate) binding pocket [chemical binding]; other site
760568004647	product (indole) binding pocket [chemical binding]; other site
760568004648	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
760568004649	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
760568004650	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
760568004651	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
760568004652	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
760568004653	glutamine binding [chemical binding]; other site
760568004654	catalytic triad [active]
760568004655	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
760568004656	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
760568004657	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
760568004658	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
760568004659	homotrimer interaction site [polypeptide binding]; other site
760568004660	active site
760568004661	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
760568004662	hexamer interface [polypeptide binding]; other site
760568004663	RNA binding site [nucleotide binding]; other site
760568004664	Histidine-zinc binding site [chemical binding]; other site
760568004665	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568004666	active site
760568004667	NTP binding site [chemical binding]; other site
760568004668	metal binding triad [ion binding]; metal-binding site
760568004669	antibiotic binding site [chemical binding]; other site
760568004670	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
760568004671	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
760568004672	RNA binding surface [nucleotide binding]; other site
760568004673	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
760568004674	active site
760568004675	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
760568004676	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
760568004677	Glucose inhibited division protein A; Region: GIDA; pfam01134
760568004678	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
760568004679	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
760568004680	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
760568004681	Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648
760568004682	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
760568004683	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
760568004684	active site
760568004685	HIGH motif; other site
760568004686	dimer interface [polypeptide binding]; other site
760568004687	KMSKS motif; other site
760568004688	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
760568004689	Peptidase family M50; Region: Peptidase_M50; pfam02163
760568004690	active site
760568004691	putative substrate binding region [chemical binding]; other site
760568004692	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
760568004693	DHH family; Region: DHH; pfam01368
760568004694	FOG: CBS domain [General function prediction only]; Region: COG0517
760568004695	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
760568004696	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
760568004697	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
760568004698	active site
760568004699	NTP binding site [chemical binding]; other site
760568004700	metal binding triad [ion binding]; metal-binding site
760568004701	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
760568004702	diaminopimelate decarboxylase; Region: lysA; TIGR01048
760568004703	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
760568004704	active site
760568004705	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
760568004706	substrate binding site [chemical binding]; other site
760568004707	catalytic residues [active]
760568004708	dimer interface [polypeptide binding]; other site
760568004709	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
760568004710	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
760568004711	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568004712	catalytic residue [active]
760568004713	Carbohydrate binding domain (family 25); Region: CBM_25; cl04060
760568004714	DNA adenine methylase (dam); Region: dam; TIGR00571
760568004715	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
760568004716	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
760568004717	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
760568004718	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
760568004719	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
760568004720	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
760568004721	SpoVA protein; Region: SpoVA; cl04298
760568004722	stage V sporulation protein AD; Validated; Region: PRK08304
760568004723	stage V sporulation protein AD; Provisional; Region: PRK12404
760568004724	SpoVA protein; Region: SpoVA; cl04298
760568004725	Dodecin; Region: Dodecin; pfam07311
760568004726	RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885
760568004727	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
760568004728	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
760568004729	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
760568004730	DNA binding residues [nucleotide binding]
760568004731	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
760568004732	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568004733	ATP binding site [chemical binding]; other site
760568004734	Mg2+ binding site [ion binding]; other site
760568004735	G-X-G motif; other site
760568004736	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
760568004737	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
760568004738	anti sigma factor interaction site; other site
760568004739	regulatory phosphorylation site [posttranslational modification]; other site
760568004740	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
760568004741	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
760568004742	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
760568004743	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
760568004744	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
760568004745	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
760568004746	active site
760568004747	metal binding site [ion binding]; metal-binding site
760568004748	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
760568004749	CotJB protein; Region: CotJB; pfam12652
760568004750	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
760568004751	dimanganese center [ion binding]; other site
760568004752	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
760568004753	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
760568004754	trimerization site [polypeptide binding]; other site
760568004755	active site
760568004756	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
760568004757	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
760568004758	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
760568004759	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
760568004760	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
760568004761	P loop nucleotide binding; other site
760568004762	switch II; other site
760568004763	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
760568004764	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
760568004765	P loop nucleotide binding; other site
760568004766	switch II; other site
760568004767	Protein of unknown function DUF72; Region: DUF72; cl00777
760568004768	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
760568004769	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
760568004770	EamA-like transporter family; Region: EamA; pfam00892
760568004771	EamA-like transporter family; Region: EamA; pfam00892
760568004772	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
760568004773	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
760568004774	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
760568004775	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
760568004776	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
760568004777	phosphopentomutase; Provisional; Region: PRK05362
760568004778	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
760568004779	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
760568004780	active site
760568004781	Int/Topo IB signature motif; other site
760568004782	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
760568004783	Uncharacterized conserved protein [Function unknown]; Region: COG2006
760568004784	4Fe-4S binding domain; Region: Fer4_6; pfam12837
760568004785	Integral membrane protein DUF95; Region: DUF95; cl00572
760568004786	Protein of unknown function (DUF3866); Region: DUF3866; pfam12982
760568004787	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
760568004788	peptidase T-like protein; Region: PepT-like; TIGR01883
760568004789	metal binding site [ion binding]; metal-binding site
760568004790	putative dimer interface [polypeptide binding]; other site
760568004791	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
760568004792	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
760568004793	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
760568004794	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
760568004795	TPP-binding site [chemical binding]; other site
760568004796	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
760568004797	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
760568004798	dimer interface [polypeptide binding]; other site
760568004799	PYR/PP interface [polypeptide binding]; other site
760568004800	TPP binding site [chemical binding]; other site
760568004801	substrate binding site [chemical binding]; other site
760568004802	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
760568004803	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
760568004804	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
760568004805	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
760568004806	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
760568004807	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
760568004808	Ligand binding site; other site
760568004809	Putative Catalytic site; other site
760568004810	DXD motif; other site
760568004811	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
760568004812	SlyX; Region: SlyX; cl01090
760568004813	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
760568004814	Thiamine pyrophosphokinase; Region: TPK; cl08415
760568004815	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
760568004816	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
760568004817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568004818	active site
760568004819	phosphorylation site [posttranslational modification]
760568004820	intermolecular recognition site; other site
760568004821	dimerization interface [polypeptide binding]; other site
760568004822	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
760568004823	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
760568004824	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
760568004825	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
760568004826	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
760568004827	Walker A/P-loop; other site
760568004828	ATP binding site [chemical binding]; other site
760568004829	Q-loop/lid; other site
760568004830	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
760568004831	Q-loop/lid; other site
760568004832	ABC transporter signature motif; other site
760568004833	Walker B; other site
760568004834	D-loop; other site
760568004835	H-loop/switch region; other site
760568004836	Arginine repressor [Transcription]; Region: ArgR; COG1438
760568004837	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
760568004838	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
760568004839	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
760568004840	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
760568004841	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
760568004842	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
760568004843	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
760568004844	RNA binding surface [nucleotide binding]; other site
760568004845	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
760568004846	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
760568004847	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
760568004848	TPP-binding site; other site
760568004849	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
760568004850	PYR/PP interface [polypeptide binding]; other site
760568004851	dimer interface [polypeptide binding]; other site
760568004852	TPP binding site [chemical binding]; other site
760568004853	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
760568004854	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
760568004855	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
760568004856	substrate binding pocket [chemical binding]; other site
760568004857	aspartate-rich region 1; other site
760568004858	substrate binding pocket [chemical binding]; other site
760568004859	aspartate-rich region 2; other site
760568004860	substrate-Mg2+ binding site; other site
760568004861	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
760568004862	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
760568004863	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
760568004864	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
760568004865	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
760568004866	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
760568004867	homodimer interface [polypeptide binding]; other site
760568004868	NADP binding site [chemical binding]; other site
760568004869	substrate binding site [chemical binding]; other site
760568004870	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
760568004871	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
760568004872	generic binding surface II; other site
760568004873	generic binding surface I; other site
760568004874	putative oxidoreductase; Provisional; Region: PRK12831
760568004875	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
760568004876	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
760568004877	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
760568004878	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
760568004879	FAD binding pocket [chemical binding]; other site
760568004880	FAD binding motif [chemical binding]; other site
760568004881	phosphate binding motif [ion binding]; other site
760568004882	beta-alpha-beta structure motif; other site
760568004883	NAD binding pocket [chemical binding]; other site
760568004884	Iron coordination center [ion binding]; other site
760568004885	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
760568004886	putative RNA binding site [nucleotide binding]; other site
760568004887	Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031
760568004888	Asp23 family; Region: Asp23; pfam03780
760568004889	Asp23 family; Region: Asp23; pfam03780
760568004890	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
760568004891	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
760568004892	ATP-grasp domain; Region: ATP-grasp_4; cl17255
760568004893	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
760568004894	pyruvate carboxylase subunit B; Validated; Region: PRK09282
760568004895	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
760568004896	active site
760568004897	catalytic residues [active]
760568004898	metal binding site [ion binding]; metal-binding site
760568004899	homodimer binding site [polypeptide binding]; other site
760568004900	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
760568004901	carboxyltransferase (CT) interaction site; other site
760568004902	biotinylation site [posttranslational modification]; other site
760568004903	Helix-turn-helix domain; Region: HTH_28; pfam13518
760568004904	Protein of unknown function (DUF497); Region: DUF497; cl01108
760568004905	Protein of unknown function (DUF3680); Region: DUF3680; pfam12441
760568004906	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
760568004907	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
760568004908	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
760568004909	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831
760568004910	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
760568004911	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
760568004912	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
760568004913	L-aspartate oxidase; Provisional; Region: PRK06175
760568004914	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
760568004915	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
760568004916	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
760568004917	transmembrane helices; other site
760568004918	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
760568004919	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
760568004920	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
760568004921	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546
760568004922	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
760568004923	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
760568004924	stage III sporulation protein SpoAB; Provisional; Region: PRK08307
760568004925	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
760568004926	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
760568004927	Walker A motif; other site
760568004928	ATP binding site [chemical binding]; other site
760568004929	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
760568004930	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
760568004931	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
760568004932	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
760568004933	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
760568004934	active site residue [active]
760568004935	Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586
760568004936	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
760568004937	elongation factor P; Validated; Region: PRK00529
760568004938	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
760568004939	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
760568004940	RNA binding site [nucleotide binding]; other site
760568004941	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
760568004942	RNA binding site [nucleotide binding]; other site
760568004943	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
760568004944	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
760568004945	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
760568004946	active site
760568004947	Dehydroquinase class II; Region: DHquinase_II; pfam01220
760568004948	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
760568004949	active site
760568004950	trimer interface [polypeptide binding]; other site
760568004951	dimer interface [polypeptide binding]; other site
760568004952	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
760568004953	YabG peptidase U57; Region: Peptidase_U57; cl05250
760568004954	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
760568004955	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
760568004956	putative active site [active]
760568004957	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
760568004958	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
760568004959	putative active site [active]
760568004960	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
760568004961	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
760568004962	catalytic nucleophile [active]
760568004963	Pilus assembly protein, PilO; Region: PilO; cl01234
760568004964	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
760568004965	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
760568004966	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
760568004967	PilX N-terminal; Region: PilX_N; pfam14341
760568004968	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
760568004969	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
760568004970	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
760568004971	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
760568004972	O-Antigen ligase; Region: Wzy_C; pfam04932
760568004973	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
760568004974	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
760568004975	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
760568004976	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
760568004977	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
760568004978	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
760568004979	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568004980	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
760568004981	Walker A motif; other site
760568004982	Walker A/P-loop; other site
760568004983	ATP binding site [chemical binding]; other site
760568004984	ATP binding site [chemical binding]; other site
760568004985	Walker B motif; other site
760568004986	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
760568004987	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
760568004988	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
760568004989	Walker A motif; other site
760568004990	ATP binding site [chemical binding]; other site
760568004991	Walker B motif; other site
760568004992	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
760568004993	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
760568004994	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
760568004995	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
760568004996	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
760568004997	putative active site [active]
760568004998	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
760568004999	active site
760568005000	dimer interface [polypeptide binding]; other site
760568005001	metal binding site [ion binding]; metal-binding site
760568005002	shikimate kinase; Provisional; Region: PRK13947
760568005003	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
760568005004	ADP binding site [chemical binding]; other site
760568005005	magnesium binding site [ion binding]; other site
760568005006	putative shikimate binding site; other site
760568005007	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
760568005008	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
760568005009	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
760568005010	Tetramer interface [polypeptide binding]; other site
760568005011	active site
760568005012	FMN-binding site [chemical binding]; other site
760568005013	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
760568005014	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
760568005015	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
760568005016	shikimate binding site; other site
760568005017	NAD(P) binding site [chemical binding]; other site
760568005018	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
760568005019	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
760568005020	active site
760568005021	motif I; other site
760568005022	motif II; other site
760568005023	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
760568005024	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
760568005025	GTP binding site; other site
760568005026	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
760568005027	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
760568005028	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
760568005029	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568005030	non-specific DNA binding site [nucleotide binding]; other site
760568005031	salt bridge; other site
760568005032	sequence-specific DNA binding site [nucleotide binding]; other site
760568005033	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
760568005034	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
760568005035	Walker A/P-loop; other site
760568005036	ATP binding site [chemical binding]; other site
760568005037	Q-loop/lid; other site
760568005038	ABC transporter signature motif; other site
760568005039	Walker B; other site
760568005040	D-loop; other site
760568005041	H-loop/switch region; other site
760568005042	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
760568005043	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
760568005044	Walker A/P-loop; other site
760568005045	ATP binding site [chemical binding]; other site
760568005046	Q-loop/lid; other site
760568005047	ABC transporter signature motif; other site
760568005048	Walker B; other site
760568005049	D-loop; other site
760568005050	H-loop/switch region; other site
760568005051	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
760568005052	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG3366
760568005053	Nucleoside recognition; Region: Gate; pfam07670
760568005054	gall11 coactivator domain; Region: gal11_coact; cd12191
760568005055	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
760568005056	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
760568005057	dimer interface [polypeptide binding]; other site
760568005058	conserved gate region; other site
760568005059	putative PBP binding loops; other site
760568005060	ABC-ATPase subunit interface; other site
760568005061	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
760568005062	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
760568005063	dimer interface [polypeptide binding]; other site
760568005064	conserved gate region; other site
760568005065	putative PBP binding loops; other site
760568005066	ABC-ATPase subunit interface; other site
760568005067	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
760568005068	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
760568005069	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
760568005070	Methyltransferase domain; Region: Methyltransf_23; pfam13489
760568005071	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568005072	S-adenosylmethionine binding site [chemical binding]; other site
760568005073	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568005074	Major Facilitator Superfamily; Region: MFS_1; pfam07690
760568005075	putative substrate translocation pore; other site
760568005076	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568005077	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
760568005078	Protein of unknown function (DUF554); Region: DUF554; pfam04474
760568005079	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
760568005080	catalytic residues [active]
760568005081	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
760568005082	catalytic residues [active]
760568005083	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
760568005084	4Fe-4S binding domain; Region: Fer4; cl02805
760568005085	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568005086	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
760568005087	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568005088	non-specific DNA binding site [nucleotide binding]; other site
760568005089	salt bridge; other site
760568005090	sequence-specific DNA binding site [nucleotide binding]; other site
760568005091	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
760568005092	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568005093	non-specific DNA binding site [nucleotide binding]; other site
760568005094	salt bridge; other site
760568005095	sequence-specific DNA binding site [nucleotide binding]; other site
760568005096	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568005097	non-specific DNA binding site [nucleotide binding]; other site
760568005098	salt bridge; other site
760568005099	sequence-specific DNA binding site [nucleotide binding]; other site
760568005100	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
760568005101	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
760568005102	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
760568005103	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
760568005104	Peptidase family U32; Region: Peptidase_U32; pfam01136
760568005105	YceG-like family; Region: YceG; pfam02618
760568005106	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
760568005107	dimerization interface [polypeptide binding]; other site
760568005108	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
760568005109	VanW like protein; Region: VanW; pfam04294
760568005110	G5 domain; Region: G5; pfam07501
760568005111	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
760568005112	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
760568005113	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
760568005114	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
760568005115	active site
760568005116	catalytic tetrad [active]
760568005117	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
760568005118	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568005119	hypothetical protein; Provisional; Region: PRK05473
760568005120	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
760568005121	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
760568005122	motif 1; other site
760568005123	active site
760568005124	motif 2; other site
760568005125	motif 3; other site
760568005126	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
760568005127	DHHA1 domain; Region: DHHA1; pfam02272
760568005128	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
760568005129	HicB family; Region: HicB; pfam05534
760568005130	YtxH-like protein; Region: YtxH; pfam12732
760568005131	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
760568005132	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
760568005133	Ligand Binding Site [chemical binding]; other site
760568005134	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
760568005135	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
760568005136	trimerization site [polypeptide binding]; other site
760568005137	active site
760568005138	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
760568005139	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
760568005140	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
760568005141	catalytic residue [active]
760568005142	Predicted transcriptional regulator [Transcription]; Region: COG1959
760568005143	Transcriptional regulator; Region: Rrf2; cl17282
760568005144	recombination factor protein RarA; Reviewed; Region: PRK13342
760568005145	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568005146	Walker A motif; other site
760568005147	ATP binding site [chemical binding]; other site
760568005148	Walker B motif; other site
760568005149	arginine finger; other site
760568005150	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
760568005151	Response regulator receiver domain; Region: Response_reg; pfam00072
760568005152	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568005153	active site
760568005154	phosphorylation site [posttranslational modification]
760568005155	intermolecular recognition site; other site
760568005156	dimerization interface [polypeptide binding]; other site
760568005157	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568005158	Zn2+ binding site [ion binding]; other site
760568005159	Mg2+ binding site [ion binding]; other site
760568005160	Response regulator receiver domain; Region: Response_reg; pfam00072
760568005161	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568005162	active site
760568005163	phosphorylation site [posttranslational modification]
760568005164	intermolecular recognition site; other site
760568005165	dimerization interface [polypeptide binding]; other site
760568005166	CHASE3 domain; Region: CHASE3; pfam05227
760568005167	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
760568005168	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
760568005169	dimer interface [polypeptide binding]; other site
760568005170	phosphorylation site [posttranslational modification]
760568005171	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568005172	ATP binding site [chemical binding]; other site
760568005173	Mg2+ binding site [ion binding]; other site
760568005174	G-X-G motif; other site
760568005175	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
760568005176	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
760568005177	dimerization interface [polypeptide binding]; other site
760568005178	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
760568005179	dimer interface [polypeptide binding]; other site
760568005180	putative CheW interface [polypeptide binding]; other site
760568005181	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
760568005182	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568005183	Zn2+ binding site [ion binding]; other site
760568005184	Mg2+ binding site [ion binding]; other site
760568005185	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
760568005186	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
760568005187	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
760568005188	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
760568005189	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568005190	active site
760568005191	phosphorylation site [posttranslational modification]
760568005192	intermolecular recognition site; other site
760568005193	dimerization interface [polypeptide binding]; other site
760568005194	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
760568005195	DNA binding site [nucleotide binding]
760568005196	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
760568005197	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
760568005198	dimerization interface [polypeptide binding]; other site
760568005199	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
760568005200	dimer interface [polypeptide binding]; other site
760568005201	phosphorylation site [posttranslational modification]
760568005202	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568005203	ATP binding site [chemical binding]; other site
760568005204	Mg2+ binding site [ion binding]; other site
760568005205	G-X-G motif; other site
760568005206	Predicted membrane protein [Function unknown]; Region: COG3212
760568005207	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
760568005208	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
760568005209	active site
760568005210	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
760568005211	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
760568005212	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
760568005213	catalytic residues [active]
760568005214	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
760568005215	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
760568005216	putative ATP binding site [chemical binding]; other site
760568005217	putative substrate interface [chemical binding]; other site
760568005218	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
760568005219	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
760568005220	dimer interface [polypeptide binding]; other site
760568005221	anticodon binding site; other site
760568005222	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
760568005223	homodimer interface [polypeptide binding]; other site
760568005224	motif 1; other site
760568005225	active site
760568005226	motif 2; other site
760568005227	GAD domain; Region: GAD; pfam02938
760568005228	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
760568005229	motif 3; other site
760568005230	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
760568005231	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
760568005232	dimer interface [polypeptide binding]; other site
760568005233	motif 1; other site
760568005234	active site
760568005235	motif 2; other site
760568005236	motif 3; other site
760568005237	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
760568005238	anticodon binding site; other site
760568005239	AAA domain; Region: AAA_31; pfam13614
760568005240	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
760568005241	P-loop; other site
760568005242	Magnesium ion binding site [ion binding]; other site
760568005243	acetyl-CoA synthetase; Provisional; Region: PRK04319
760568005244	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
760568005245	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
760568005246	acyl-activating enzyme (AAE) consensus motif; other site
760568005247	AMP binding site [chemical binding]; other site
760568005248	active site
760568005249	CoA binding site [chemical binding]; other site
760568005250	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
760568005251	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
760568005252	putative active site [active]
760568005253	dimerization interface [polypeptide binding]; other site
760568005254	putative tRNAtyr binding site [nucleotide binding]; other site
760568005255	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
760568005256	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
760568005257	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568005258	non-specific DNA binding site [nucleotide binding]; other site
760568005259	salt bridge; other site
760568005260	sequence-specific DNA binding site [nucleotide binding]; other site
760568005261	Bacterial Ig-like domain; Region: Big_5; pfam13205
760568005262	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568005263	Bacterial Ig-like domain; Region: Big_5; pfam13205
760568005264	S-layer homology domain; Region: SLH; pfam00395
760568005265	S-layer homology domain; Region: SLH; pfam00395
760568005266	Transposase [DNA replication, recombination, and repair]; Region: COG5421
760568005267	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
760568005268	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
760568005269	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
760568005270	Beta-lactamase; Region: Beta-lactamase; cl17358
760568005271	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
760568005272	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
760568005273	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
760568005274	DNA binding residues [nucleotide binding]
760568005275	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
760568005276	catalytic residues [active]
760568005277	catalytic nucleophile [active]
760568005278	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
760568005279	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
760568005280	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
760568005281	putative active site [active]
760568005282	Methyltransferase domain; Region: Methyltransf_23; pfam13489
760568005283	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568005284	S-adenosylmethionine binding site [chemical binding]; other site
760568005285	SEC-C motif; Region: SEC-C; pfam02810
760568005286	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
760568005287	TPR motif; other site
760568005288	binding surface
760568005289	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
760568005290	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
760568005291	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
760568005292	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
760568005293	Predicted integral membrane protein [Function unknown]; Region: COG5652
760568005294	Restriction endonuclease; Region: Mrr_cat; pfam04471
760568005295	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
760568005296	MviN-like protein; Region: MVIN; pfam03023
760568005297	YcfA-like protein; Region: YcfA; pfam07927
760568005298	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
760568005299	AAA ATPase domain; Region: AAA_15; pfam13175
760568005300	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568005301	Walker A/P-loop; other site
760568005302	ATP binding site [chemical binding]; other site
760568005303	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568005304	ABC transporter signature motif; other site
760568005305	Walker B; other site
760568005306	D-loop; other site
760568005307	H-loop/switch region; other site
760568005308	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
760568005309	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
760568005310	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
760568005311	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
760568005312	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
760568005313	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
760568005314	active site
760568005315	O-Antigen ligase; Region: Wzy_C; pfam04932
760568005316	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
760568005317	Sulfatase; Region: Sulfatase; cl17466
760568005318	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
760568005319	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
760568005320	Active Sites [active]
760568005321	Transposase; Region: DEDD_Tnp_IS110; pfam01548
760568005322	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
760568005323	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
760568005324	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
760568005325	active site
760568005326	catalytic residues [active]
760568005327	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
760568005328	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
760568005329	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
760568005330	Bacterial sugar transferase; Region: Bac_transf; pfam02397
760568005331	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
760568005332	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
760568005333	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
760568005334	Chain length determinant protein; Region: Wzz; pfam02706
760568005335	Chain length determinant protein; Region: Wzz; cl15801
760568005336	O-Antigen ligase; Region: Wzy_C; cl04850
760568005337	O-Antigen ligase; Region: Wzy_C; pfam04932
760568005338	S-layer homology domain; Region: SLH; pfam00395
760568005339	S-layer homology domain; Region: SLH; pfam00395
760568005340	S-layer homology domain; Region: SLH; pfam00395
760568005341	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
760568005342	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568005343	Zn2+ binding site [ion binding]; other site
760568005344	Mg2+ binding site [ion binding]; other site
760568005345	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
760568005346	synthetase active site [active]
760568005347	NTP binding site [chemical binding]; other site
760568005348	metal binding site [ion binding]; metal-binding site
760568005349	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
760568005350	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
760568005351	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
760568005352	active site
760568005353	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
760568005354	DHH family; Region: DHH; pfam01368
760568005355	DHHA1 domain; Region: DHHA1; pfam02272
760568005356	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
760568005357	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
760568005358	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
760568005359	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
760568005360	active site residue [active]
760568005361	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
760568005362	CHASE3 domain; Region: CHASE3; cl05000
760568005363	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
760568005364	dimerization interface [polypeptide binding]; other site
760568005365	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
760568005366	dimer interface [polypeptide binding]; other site
760568005367	putative CheW interface [polypeptide binding]; other site
760568005368	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
760568005369	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
760568005370	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568005371	Walker A motif; other site
760568005372	ATP binding site [chemical binding]; other site
760568005373	Walker B motif; other site
760568005374	arginine finger; other site
760568005375	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
760568005376	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
760568005377	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
760568005378	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
760568005379	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
760568005380	active site
760568005381	Glyco_18 domain; Region: Glyco_18; smart00636
760568005382	hypothetical protein; Reviewed; Region: PRK12497
760568005383	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
760568005384	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
760568005385	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
760568005386	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
760568005387	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
760568005388	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
760568005389	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
760568005390	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
760568005391	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
760568005392	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
760568005393	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
760568005394	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
760568005395	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
760568005396	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
760568005397	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
760568005398	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
760568005399	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
760568005400	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
760568005401	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
760568005402	NADH dehydrogenase subunit B; Validated; Region: PRK06411
760568005403	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
760568005404	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
760568005405	RNA/DNA hybrid binding site [nucleotide binding]; other site
760568005406	active site
760568005407	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
760568005408	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
760568005409	GTP/Mg2+ binding site [chemical binding]; other site
760568005410	G4 box; other site
760568005411	G5 box; other site
760568005412	G1 box; other site
760568005413	Switch I region; other site
760568005414	G2 box; other site
760568005415	G3 box; other site
760568005416	Switch II region; other site
760568005417	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
760568005418	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
760568005419	Catalytic site [active]
760568005420	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
760568005421	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
760568005422	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
760568005423	RimM N-terminal domain; Region: RimM; pfam01782
760568005424	PRC-barrel domain; Region: PRC; pfam05239
760568005425	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
760568005426	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
760568005427	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
760568005428	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
760568005429	signal recognition particle protein; Provisional; Region: PRK10867
760568005430	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
760568005431	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
760568005432	P loop; other site
760568005433	GTP binding site [chemical binding]; other site
760568005434	Signal peptide binding domain; Region: SRP_SPB; pfam02978
760568005435	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
760568005436	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
760568005437	DNA binding residues [nucleotide binding]
760568005438	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
760568005439	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
760568005440	inhibitor-cofactor binding pocket; inhibition site
760568005441	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568005442	catalytic residue [active]
760568005443	bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529
760568005444	Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA.  ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH)...; Region: ACS_2; cd01917
760568005445	CODH interaction site; other site
760568005446	CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598
760568005447	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
760568005448	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
760568005449	ACS interaction site; other site
760568005450	CODH interaction site; other site
760568005451	cubane metal cluster (B-cluster) [ion binding]; other site
760568005452	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
760568005453	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
760568005454	metal binding site 2 [ion binding]; metal-binding site
760568005455	putative DNA binding helix; other site
760568005456	metal binding site 1 [ion binding]; metal-binding site
760568005457	dimer interface [polypeptide binding]; other site
760568005458	structural Zn2+ binding site [ion binding]; other site
760568005459	Uncharacterized conserved protein [Function unknown]; Region: COG1433
760568005460	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568005461	PAS domain; Region: PAS_9; pfam13426
760568005462	putative active site [active]
760568005463	heme pocket [chemical binding]; other site
760568005464	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
760568005465	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568005466	Walker A motif; other site
760568005467	ATP binding site [chemical binding]; other site
760568005468	Walker B motif; other site
760568005469	arginine finger; other site
760568005470	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
760568005471	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
760568005472	Cysteine-rich domain; Region: CCG; pfam02754
760568005473	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
760568005474	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
760568005475	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568005476	non-specific DNA binding site [nucleotide binding]; other site
760568005477	salt bridge; other site
760568005478	sequence-specific DNA binding site [nucleotide binding]; other site
760568005479	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
760568005480	Histone deacetylase domain; Region: Hist_deacetyl; pfam00850
760568005481	active site
760568005482	metal binding site [ion binding]; metal-binding site
760568005483	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
760568005484	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
760568005485	UbiA prenyltransferase family; Region: UbiA; pfam01040
760568005486	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
760568005487	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568005488	Walker A/P-loop; other site
760568005489	ATP binding site [chemical binding]; other site
760568005490	Q-loop/lid; other site
760568005491	ABC transporter signature motif; other site
760568005492	Walker B; other site
760568005493	D-loop; other site
760568005494	H-loop/switch region; other site
760568005495	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
760568005496	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
760568005497	TM-ABC transporter signature motif; other site
760568005498	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
760568005499	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
760568005500	zinc binding site [ion binding]; other site
760568005501	putative ligand binding site [chemical binding]; other site
760568005502	Domain of unknown function (DUF202); Region: DUF202; cl09954
760568005503	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
760568005504	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
760568005505	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
760568005506	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
760568005507	stage II sporulation protein P; Region: spore_II_P; TIGR02867
760568005508	Baculovirus P24 capsid protein; Region: Baculo_p24; pfam05073
760568005509	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568005510	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568005511	metal binding site [ion binding]; metal-binding site
760568005512	active site
760568005513	I-site; other site
760568005514	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
760568005515	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
760568005516	ABC-ATPase subunit  interface; other site
760568005517	dimer interface [polypeptide binding]; other site
760568005518	putative PBP binding regions; other site
760568005519	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
760568005520	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
760568005521	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
760568005522	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
760568005523	intersubunit interface [polypeptide binding]; other site
760568005524	Methyltransferase domain; Region: Methyltransf_31; pfam13847
760568005525	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568005526	S-adenosylmethionine binding site [chemical binding]; other site
760568005527	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568005528	active site
760568005529	NTP binding site [chemical binding]; other site
760568005530	metal binding triad [ion binding]; metal-binding site
760568005531	antibiotic binding site [chemical binding]; other site
760568005532	FeoA domain; Region: FeoA; pfam04023
760568005533	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568005534	active site
760568005535	NTP binding site [chemical binding]; other site
760568005536	metal binding triad [ion binding]; metal-binding site
760568005537	antibiotic binding site [chemical binding]; other site
760568005538	Predicted metal-binding protein [Function unknown]; Region: COG5561
760568005539	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
760568005540	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
760568005541	putative active site [active]
760568005542	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
760568005543	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
760568005544	Transposase domain (DUF772); Region: DUF772; pfam05598
760568005545	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
760568005546	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
760568005547	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
760568005548	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568005549	FeS/SAM binding site; other site
760568005550	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
760568005551	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
760568005552	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
760568005553	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
760568005554	Predicted amidohydrolase [General function prediction only]; Region: COG0388
760568005555	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
760568005556	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
760568005557	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
760568005558	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
760568005559	Walker A/P-loop; other site
760568005560	ATP binding site [chemical binding]; other site
760568005561	Q-loop/lid; other site
760568005562	ABC transporter signature motif; other site
760568005563	Walker B; other site
760568005564	D-loop; other site
760568005565	H-loop/switch region; other site
760568005566	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
760568005567	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
760568005568	ABC-ATPase subunit  interface; other site
760568005569	dimer interface [polypeptide binding]; other site
760568005570	putative PBP binding regions; other site
760568005571	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
760568005572	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
760568005573	putative ligand binding site [chemical binding]; other site
760568005574	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
760568005575	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
760568005576	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
760568005577	MarR family; Region: MarR; pfam01047
760568005578	MarR family; Region: MarR_2; cl17246
760568005579	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
760568005580	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568005581	Walker A/P-loop; other site
760568005582	ATP binding site [chemical binding]; other site
760568005583	Q-loop/lid; other site
760568005584	ABC transporter signature motif; other site
760568005585	Walker B; other site
760568005586	D-loop; other site
760568005587	H-loop/switch region; other site
760568005588	ABC-2 type transporter; Region: ABC2_membrane; cl17235
760568005589	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
760568005590	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
760568005591	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
760568005592	Transposase [DNA replication, recombination, and repair]; Region: COG5421
760568005593	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
760568005594	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316
760568005595	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
760568005596	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316
760568005597	nitrogenase reductase-like protein; Reviewed; Region: PRK13230
760568005598	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
760568005599	Nucleotide-binding sites [chemical binding]; other site
760568005600	Walker A motif; other site
760568005601	Switch I region of nucleotide binding site; other site
760568005602	Fe4S4 binding sites [ion binding]; other site
760568005603	Switch II region of nucleotide binding site; other site
760568005604	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316
760568005605	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
760568005606	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316
760568005607	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
760568005608	Transposase; Region: DEDD_Tnp_IS110; pfam01548
760568005609	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
760568005610	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
760568005611	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
760568005612	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
760568005613	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
760568005614	PQQ-like domain; Region: PQQ_2; pfam13360
760568005615	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
760568005616	Transposase; Region: HTH_Tnp_1; pfam01527
760568005617	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
760568005618	HTH-like domain; Region: HTH_21; pfam13276
760568005619	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
760568005620	Integrase core domain; Region: rve; pfam00665
760568005621	Integrase core domain; Region: rve_3; pfam13683
760568005622	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
760568005623	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
760568005624	Walker A/P-loop; other site
760568005625	ATP binding site [chemical binding]; other site
760568005626	Q-loop/lid; other site
760568005627	ABC transporter signature motif; other site
760568005628	Walker B; other site
760568005629	D-loop; other site
760568005630	H-loop/switch region; other site
760568005631	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
760568005632	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
760568005633	Walker A/P-loop; other site
760568005634	ATP binding site [chemical binding]; other site
760568005635	Q-loop/lid; other site
760568005636	ABC transporter signature motif; other site
760568005637	Walker B; other site
760568005638	D-loop; other site
760568005639	H-loop/switch region; other site
760568005640	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
760568005641	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
760568005642	intersubunit interface [polypeptide binding]; other site
760568005643	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
760568005644	ABC-2 type transporter; Region: ABC2_membrane; cl17235
760568005645	ABC-2 type transporter; Region: ABC2_membrane; cl17235
760568005646	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
760568005647	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
760568005648	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568005649	Walker A/P-loop; other site
760568005650	ATP binding site [chemical binding]; other site
760568005651	Q-loop/lid; other site
760568005652	ABC transporter signature motif; other site
760568005653	Walker B; other site
760568005654	D-loop; other site
760568005655	H-loop/switch region; other site
760568005656	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
760568005657	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
760568005658	Walker A/P-loop; other site
760568005659	ATP binding site [chemical binding]; other site
760568005660	Q-loop/lid; other site
760568005661	ABC transporter signature motif; other site
760568005662	Walker B; other site
760568005663	D-loop; other site
760568005664	H-loop/switch region; other site
760568005665	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568005666	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
760568005667	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
760568005668	intersubunit interface [polypeptide binding]; other site
760568005669	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
760568005670	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
760568005671	ABC-ATPase subunit  interface; other site
760568005672	dimer interface [polypeptide binding]; other site
760568005673	putative PBP binding regions; other site
760568005674	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
760568005675	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
760568005676	intersubunit interface [polypeptide binding]; other site
760568005677	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
760568005678	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
760568005679	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
760568005680	ABC-2 type transporter; Region: ABC2_membrane; cl17235
760568005681	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
760568005682	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
760568005683	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568005684	Walker A/P-loop; other site
760568005685	ATP binding site [chemical binding]; other site
760568005686	Q-loop/lid; other site
760568005687	ABC transporter signature motif; other site
760568005688	Walker B; other site
760568005689	D-loop; other site
760568005690	H-loop/switch region; other site
760568005691	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
760568005692	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
760568005693	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
760568005694	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
760568005695	metal ion-dependent adhesion site (MIDAS); other site
760568005696	Domain of unknown function (DUF3842); Region: DUF3842; pfam12953
760568005697	PQQ-like domain; Region: PQQ_2; pfam13360
760568005698	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
760568005699	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
760568005700	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
760568005701	Walker A/P-loop; other site
760568005702	ATP binding site [chemical binding]; other site
760568005703	Q-loop/lid; other site
760568005704	ABC transporter signature motif; other site
760568005705	Walker B; other site
760568005706	D-loop; other site
760568005707	H-loop/switch region; other site
760568005708	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
760568005709	Walker A/P-loop; other site
760568005710	ATP binding site [chemical binding]; other site
760568005711	Q-loop/lid; other site
760568005712	ABC transporter signature motif; other site
760568005713	Walker B; other site
760568005714	D-loop; other site
760568005715	H-loop/switch region; other site
760568005716	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
760568005717	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
760568005718	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
760568005719	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
760568005720	S-layer homology domain; Region: SLH; pfam00395
760568005721	S-layer homology domain; Region: SLH; pfam00395
760568005722	S-layer homology domain; Region: SLH; pfam00395
760568005723	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
760568005724	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
760568005725	S-layer homology domain; Region: SLH; pfam00395
760568005726	S-layer homology domain; Region: SLH; pfam00395
760568005727	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
760568005728	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
760568005729	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
760568005730	Uncharacterized conserved protein (DUF2149); Region: DUF2149; cl01960
760568005731	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
760568005732	Predicted transporter (DUF2162); Region: DUF2162; cl01990
760568005733	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
760568005734	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
760568005735	substrate-cofactor binding pocket; other site
760568005736	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568005737	catalytic residue [active]
760568005738	6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322
760568005739	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
760568005740	putative active site [active]
760568005741	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
760568005742	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
760568005743	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
760568005744	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
760568005745	Histidine kinase; Region: His_kinase; pfam06580
760568005746	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568005747	ATP binding site [chemical binding]; other site
760568005748	Mg2+ binding site [ion binding]; other site
760568005749	G-X-G motif; other site
760568005750	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
760568005751	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568005752	active site
760568005753	phosphorylation site [posttranslational modification]
760568005754	intermolecular recognition site; other site
760568005755	dimerization interface [polypeptide binding]; other site
760568005756	LytTr DNA-binding domain; Region: LytTR; pfam04397
760568005757	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
760568005758	Carbon starvation protein CstA; Region: CstA; pfam02554
760568005759	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
760568005760	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
760568005761	putative ADP-ribose binding site [chemical binding]; other site
760568005762	putative active site [active]
760568005763	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
760568005764	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
760568005765	catalytic triad [active]
760568005766	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
760568005767	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
760568005768	AP (apurinic/apyrimidinic) site pocket; other site
760568005769	DNA interaction; other site
760568005770	Metal-binding active site; metal-binding site
760568005771	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
760568005772	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
760568005773	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
760568005774	active site
760568005775	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
760568005776	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
760568005777	Walker A/P-loop; other site
760568005778	ATP binding site [chemical binding]; other site
760568005779	Q-loop/lid; other site
760568005780	ABC transporter signature motif; other site
760568005781	Walker B; other site
760568005782	D-loop; other site
760568005783	H-loop/switch region; other site
760568005784	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
760568005785	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
760568005786	Walker A/P-loop; other site
760568005787	ATP binding site [chemical binding]; other site
760568005788	Q-loop/lid; other site
760568005789	ABC transporter signature motif; other site
760568005790	Walker B; other site
760568005791	D-loop; other site
760568005792	H-loop/switch region; other site
760568005793	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
760568005794	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
760568005795	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
760568005796	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845
760568005797	phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293
760568005798	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
760568005799	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
760568005800	dimer interface [polypeptide binding]; other site
760568005801	conserved gate region; other site
760568005802	ABC-ATPase subunit interface; other site
760568005803	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
760568005804	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
760568005805	Walker A/P-loop; other site
760568005806	ATP binding site [chemical binding]; other site
760568005807	Q-loop/lid; other site
760568005808	ABC transporter signature motif; other site
760568005809	Walker B; other site
760568005810	D-loop; other site
760568005811	H-loop/switch region; other site
760568005812	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
760568005813	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
760568005814	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
760568005815	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
760568005816	DNA-binding site [nucleotide binding]; DNA binding site
760568005817	UTRA domain; Region: UTRA; pfam07702
760568005818	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
760568005819	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
760568005820	glutamine binding [chemical binding]; other site
760568005821	catalytic triad [active]
760568005822	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
760568005823	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
760568005824	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
760568005825	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
760568005826	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
760568005827	homodimer interface [polypeptide binding]; other site
760568005828	substrate-cofactor binding pocket; other site
760568005829	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568005830	catalytic residue [active]
760568005831	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
760568005832	binding surface
760568005833	TPR motif; other site
760568005834	TPR repeat; Region: TPR_11; pfam13414
760568005835	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568005836	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
760568005837	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
760568005838	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568005839	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568005840	metal binding site [ion binding]; metal-binding site
760568005841	active site
760568005842	I-site; other site
760568005843	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
760568005844	PemK-like protein; Region: PemK; pfam02452
760568005845	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
760568005846	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
760568005847	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
760568005848	putative RNA binding site [nucleotide binding]; other site
760568005849	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568005850	S-adenosylmethionine binding site [chemical binding]; other site
760568005851	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
760568005852	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
760568005853	active site
760568005854	putative substrate binding pocket [chemical binding]; other site
760568005855	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
760568005856	intersubunit interface [polypeptide binding]; other site
760568005857	active site
760568005858	Zn2+ binding site [ion binding]; other site
760568005859	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
760568005860	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
760568005861	homotetramer interface [polypeptide binding]; other site
760568005862	ligand binding site [chemical binding]; other site
760568005863	catalytic site [active]
760568005864	NAD binding site [chemical binding]; other site
760568005865	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
760568005866	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
760568005867	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
760568005868	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
760568005869	dimerization interface [polypeptide binding]; other site
760568005870	putative DNA binding site [nucleotide binding]; other site
760568005871	putative Zn2+ binding site [ion binding]; other site
760568005872	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
760568005873	dinuclear metal binding motif [ion binding]; other site
760568005874	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
760568005875	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
760568005876	Spore germination protein; Region: Spore_permease; cl17796
760568005877	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
760568005878	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
760568005879	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
760568005880	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
760568005881	P loop; other site
760568005882	GTP binding site [chemical binding]; other site
760568005883	ribonuclease III; Reviewed; Region: rnc; PRK00102
760568005884	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
760568005885	dimerization interface [polypeptide binding]; other site
760568005886	active site
760568005887	metal binding site [ion binding]; metal-binding site
760568005888	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
760568005889	dsRNA binding site [nucleotide binding]; other site
760568005890	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
760568005891	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
760568005892	dimer interface [polypeptide binding]; other site
760568005893	active site
760568005894	acyl carrier protein; Provisional; Region: acpP; PRK00982
760568005895	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
760568005896	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
760568005897	NAD(P) binding site [chemical binding]; other site
760568005898	active site
760568005899	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
760568005900	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
760568005901	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
760568005902	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
760568005903	FMN binding site [chemical binding]; other site
760568005904	substrate binding site [chemical binding]; other site
760568005905	putative catalytic residue [active]
760568005906	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
760568005907	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
760568005908	dimer interface [polypeptide binding]; other site
760568005909	active site
760568005910	CoA binding pocket [chemical binding]; other site
760568005911	putative phosphate acyltransferase; Provisional; Region: PRK05331
760568005912	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
760568005913	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
760568005914	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
760568005915	active site 2 [active]
760568005916	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
760568005917	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
760568005918	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
760568005919	DRTGG domain; Region: DRTGG; pfam07085
760568005920	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
760568005921	CoA binding domain; Region: CoA_binding_2; pfam13380
760568005922	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
760568005923	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
760568005924	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
760568005925	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
760568005926	Ligand Binding Site [chemical binding]; other site
760568005927	Transcriptional regulator [Transcription]; Region: LysR; COG0583
760568005928	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
760568005929	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
760568005930	putative dimerization interface [polypeptide binding]; other site
760568005931	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
760568005932	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
760568005933	catalytic loop [active]
760568005934	iron binding site [ion binding]; other site
760568005935	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
760568005936	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
760568005937	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
760568005938	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
760568005939	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
760568005940	dimer interface [polypeptide binding]; other site
760568005941	[2Fe-2S] cluster binding site [ion binding]; other site
760568005942	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
760568005943	SLBB domain; Region: SLBB; pfam10531
760568005944	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
760568005945	4Fe-4S binding domain; Region: Fer4; pfam00037
760568005946	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
760568005947	4Fe-4S binding domain; Region: Fer4; pfam00037
760568005948	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
760568005949	dimer interface [polypeptide binding]; other site
760568005950	[2Fe-2S] cluster binding site [ion binding]; other site
760568005951	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
760568005952	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568005953	ATP binding site [chemical binding]; other site
760568005954	Mg2+ binding site [ion binding]; other site
760568005955	G-X-G motif; other site
760568005956	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
760568005957	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
760568005958	putative dimer interface [polypeptide binding]; other site
760568005959	[2Fe-2S] cluster binding site [ion binding]; other site
760568005960	DRTGG domain; Region: DRTGG; pfam07085
760568005961	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
760568005962	4Fe-4S binding domain; Region: Fer4; pfam00037
760568005963	4Fe-4S binding domain; Region: Fer4; pfam00037
760568005964	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
760568005965	Putative Fe-S cluster; Region: FeS; cl17515
760568005966	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
760568005967	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568005968	ATP binding site [chemical binding]; other site
760568005969	Mg2+ binding site [ion binding]; other site
760568005970	G-X-G motif; other site
760568005971	DRTGG domain; Region: DRTGG; pfam07085
760568005972	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
760568005973	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568005974	FeS/SAM binding site; other site
760568005975	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
760568005976	biotin synthase; Provisional; Region: PRK07094
760568005977	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568005978	FeS/SAM binding site; other site
760568005979	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
760568005980	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
760568005981	G1 box; other site
760568005982	GTP/Mg2+ binding site [chemical binding]; other site
760568005983	Switch I region; other site
760568005984	G2 box; other site
760568005985	Switch II region; other site
760568005986	G3 box; other site
760568005987	G4 box; other site
760568005988	G5 box; other site
760568005989	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
760568005990	Aspartase; Region: Aspartase; cd01357
760568005991	active sites [active]
760568005992	tetramer interface [polypeptide binding]; other site
760568005993	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
760568005994	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
760568005995	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
760568005996	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
760568005997	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
760568005998	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
760568005999	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
760568006000	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
760568006001	Homeodomain-like domain; Region: HTH_23; cl17451
760568006002	Transposase domain (DUF772); Region: DUF772; pfam05598
760568006003	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
760568006004	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
760568006005	Restriction endonuclease; Region: Mrr_cat; pfam04471
760568006006	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
760568006007	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
760568006008	DEAD-like helicases superfamily; Region: DEXDc; smart00487
760568006009	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
760568006010	ATP binding site [chemical binding]; other site
760568006011	putative Mg++ binding site [ion binding]; other site
760568006012	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
760568006013	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
760568006014	nucleotide binding region [chemical binding]; other site
760568006015	ATP-binding site [chemical binding]; other site
760568006016	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
760568006017	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
760568006018	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
760568006019	ATP binding site [chemical binding]; other site
760568006020	putative Mg++ binding site [ion binding]; other site
760568006021	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
760568006022	ATP-binding site [chemical binding]; other site
760568006023	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
760568006024	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
760568006025	active site
760568006026	8-oxo-dGMP binding site [chemical binding]; other site
760568006027	nudix motif; other site
760568006028	metal binding site [ion binding]; metal-binding site
760568006029	Protein of unknown function DUF262; Region: DUF262; pfam03235
760568006030	Uncharacterized conserved protein [Function unknown]; Region: COG1479
760568006031	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
760568006032	Predicted transcriptional regulator [Transcription]; Region: COG2378
760568006033	HTH domain; Region: HTH_11; pfam08279
760568006034	WYL domain; Region: WYL; pfam13280
760568006035	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
760568006036	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
760568006037	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
760568006038	generic binding surface I; other site
760568006039	generic binding surface II; other site
760568006040	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568006041	Zn2+ binding site [ion binding]; other site
760568006042	Mg2+ binding site [ion binding]; other site
760568006043	Predicted membrane protein [Function unknown]; Region: COG1950
760568006044	Bifunctional nuclease; Region: DNase-RNase; pfam02577
760568006045	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
760568006046	Prephenate dehydratase; Region: PDT; pfam00800
760568006047	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
760568006048	putative L-Phe binding site [chemical binding]; other site
760568006049	Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605
760568006050	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
760568006051	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
760568006052	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
760568006053	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
760568006054	CoA-transferase family III; Region: CoA_transf_3; pfam02515
760568006055	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
760568006056	CoA binding domain; Region: CoA_binding_2; pfam13380
760568006057	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
760568006058	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
760568006059	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
760568006060	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
760568006061	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
760568006062	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
760568006063	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
760568006064	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
760568006065	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
760568006066	Probable zinc-binding domain; Region: zf-trcl; pfam13451
760568006067	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
760568006068	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
760568006069	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
760568006070	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
760568006071	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
760568006072	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
760568006073	Sporulation and spore germination; Region: Germane; pfam10646
760568006074	Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648
760568006075	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
760568006076	substrate binding site [chemical binding]; other site
760568006077	multimerization interface [polypeptide binding]; other site
760568006078	ATP binding site [chemical binding]; other site
760568006079	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
760568006080	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
760568006081	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
760568006082	PASTA domain; Region: PASTA; pfam03793
760568006083	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
760568006084	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
760568006085	catalytic core [active]
760568006086	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
760568006087	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
760568006088	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568006089	homodimer interface [polypeptide binding]; other site
760568006090	catalytic residue [active]
760568006091	cobalamin synthase; Reviewed; Region: cobS; PRK00235
760568006092	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
760568006093	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
760568006094	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
760568006095	catalytic triad [active]
760568006096	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
760568006097	cobyric acid synthase; Provisional; Region: PRK00784
760568006098	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
760568006099	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
760568006100	catalytic triad [active]
760568006101	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
760568006102	homotrimer interface [polypeptide binding]; other site
760568006103	Walker A motif; other site
760568006104	GTP binding site [chemical binding]; other site
760568006105	Walker B motif; other site
760568006106	Domain of unknown function (DUF3842); Region: DUF3842; pfam12953
760568006107	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
760568006108	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
760568006109	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568006110	homodimer interface [polypeptide binding]; other site
760568006111	catalytic residue [active]
760568006112	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
760568006113	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
760568006114	active site
760568006115	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
760568006116	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
760568006117	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
760568006118	active site
760568006119	dimer interface [polypeptide binding]; other site
760568006120	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
760568006121	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
760568006122	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
760568006123	putative active site [active]
760568006124	metal binding site [ion binding]; metal-binding site
760568006125	homodimer binding site [polypeptide binding]; other site
760568006126	Domain of unknown function (DUF3552); Region: DUF3552; pfam12072
760568006127	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
760568006128	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568006129	Zn2+ binding site [ion binding]; other site
760568006130	Mg2+ binding site [ion binding]; other site
760568006131	recombinase A; Provisional; Region: recA; PRK09354
760568006132	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
760568006133	hexamer interface [polypeptide binding]; other site
760568006134	Walker A motif; other site
760568006135	ATP binding site [chemical binding]; other site
760568006136	Walker B motif; other site
760568006137	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
760568006138	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
760568006139	competence damage-inducible protein A; Provisional; Region: PRK00549
760568006140	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
760568006141	putative MPT binding site; other site
760568006142	Competence-damaged protein; Region: CinA; pfam02464
760568006143	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
760568006144	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568006145	Walker A motif; other site
760568006146	ATP binding site [chemical binding]; other site
760568006147	Walker B motif; other site
760568006148	arginine finger; other site
760568006149	Peptidase family M41; Region: Peptidase_M41; pfam01434
760568006150	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
760568006151	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
760568006152	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
760568006153	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568006154	FeS/SAM binding site; other site
760568006155	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
760568006156	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568006157	non-specific DNA binding site [nucleotide binding]; other site
760568006158	salt bridge; other site
760568006159	sequence-specific DNA binding site [nucleotide binding]; other site
760568006160	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
760568006161	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
760568006162	active site residue [active]
760568006163	AAA domain; Region: AAA_17; pfam13207
760568006164	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
760568006165	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
760568006166	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
760568006167	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
760568006168	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
760568006169	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
760568006170	Cysteine-rich domain; Region: CCG; pfam02754
760568006171	Cysteine-rich domain; Region: CCG; pfam02754
760568006172	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
760568006173	L-lactate permease; Region: Lactate_perm; cl00701
760568006174	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
760568006175	Transcriptional regulators [Transcription]; Region: FadR; COG2186
760568006176	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
760568006177	DNA-binding site [nucleotide binding]; DNA binding site
760568006178	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
760568006179	Bacitracin resistance protein BacA; Region: BacA; pfam02673
760568006180	YlzJ-like protein; Region: YlzJ; pfam14035
760568006181	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
760568006182	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
760568006183	catalytic residues [active]
760568006184	catalytic nucleophile [active]
760568006185	Recombinase; Region: Recombinase; pfam07508
760568006186	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
760568006187	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
760568006188	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
760568006189	ATP binding site [chemical binding]; other site
760568006190	Walker B motif; other site
760568006191	HEPN domain; Region: HEPN; cl00824
760568006192	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568006193	active site
760568006194	NTP binding site [chemical binding]; other site
760568006195	metal binding triad [ion binding]; metal-binding site
760568006196	antibiotic binding site [chemical binding]; other site
760568006197	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
760568006198	oligomeric interface; other site
760568006199	homodimer interface [polypeptide binding]; other site
760568006200	putative active site [active]
760568006201	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
760568006202	active site
760568006203	DNA binding site [nucleotide binding]
760568006204	Int/Topo IB signature motif; other site
760568006205	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
760568006206	Rubrerythrin [Energy production and conversion]; Region: COG1592
760568006207	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
760568006208	active site
760568006209	metal binding site [ion binding]; metal-binding site
760568006210	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
760568006211	MPN+ (JAMM) motif; other site
760568006212	Zinc-binding site [ion binding]; other site
760568006213	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
760568006214	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
760568006215	Zn binding site [ion binding]; other site
760568006216	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
760568006217	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
760568006218	RNA binding site [nucleotide binding]; other site
760568006219	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
760568006220	DNA topoisomerase III; Provisional; Region: PRK07726
760568006221	active site
760568006222	putative interdomain interaction site [polypeptide binding]; other site
760568006223	putative metal-binding site [ion binding]; other site
760568006224	putative nucleotide binding site [chemical binding]; other site
760568006225	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
760568006226	domain I; other site
760568006227	DNA binding groove [nucleotide binding]
760568006228	phosphate binding site [ion binding]; other site
760568006229	domain II; other site
760568006230	domain III; other site
760568006231	nucleotide binding site [chemical binding]; other site
760568006232	catalytic site [active]
760568006233	domain IV; other site
760568006234	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
760568006235	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
760568006236	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
760568006237	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
760568006238	PRTRC system protein D; Region: PRTRC_D; TIGR03739
760568006239	Mg binding site [ion binding]; other site
760568006240	nucleotide binding site [chemical binding]; other site
760568006241	putative protofilament interface [polypeptide binding]; other site
760568006242	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568006243	Zn2+ binding site [ion binding]; other site
760568006244	Mg2+ binding site [ion binding]; other site
760568006245	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
760568006246	Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729
760568006247	putative active site [active]
760568006248	redox center [active]
760568006249	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
760568006250	VanW like protein; Region: VanW; pfam04294
760568006251	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
760568006252	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
760568006253	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
760568006254	Walker A motif; other site
760568006255	ATP binding site [chemical binding]; other site
760568006256	Walker B motif; other site
760568006257	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
760568006258	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
760568006259	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
760568006260	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
760568006261	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
760568006262	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568006263	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568006264	metal binding site [ion binding]; metal-binding site
760568006265	active site
760568006266	I-site; other site
760568006267	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
760568006268	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
760568006269	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
760568006270	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
760568006271	CAAX protease self-immunity; Region: Abi; pfam02517
760568006272	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568006273	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
760568006274	putative active site [active]
760568006275	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
760568006276	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
760568006277	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
760568006278	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
760568006279	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568006280	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568006281	metal binding site [ion binding]; metal-binding site
760568006282	active site
760568006283	I-site; other site
760568006284	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
760568006285	N-acetyl-D-glucosamine binding site [chemical binding]; other site
760568006286	catalytic residue [active]
760568006287	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
760568006288	Peptidase family M23; Region: Peptidase_M23; pfam01551
760568006289	Domain of unknown function DUF87; Region: DUF87; pfam01935
760568006290	AAA-like domain; Region: AAA_10; pfam12846
760568006291	Transposase [DNA replication, recombination, and repair]; Region: COG5421
760568006292	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
760568006293	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
760568006294	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
760568006295	active site
760568006296	DNA binding site [nucleotide binding]
760568006297	Int/Topo IB signature motif; other site
760568006298	DNA adenine methylase (dam); Region: dam; TIGR00571
760568006299	DNA methylase; Region: N6_N4_Mtase; cl17433
760568006300	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
760568006301	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568006302	non-specific DNA binding site [nucleotide binding]; other site
760568006303	salt bridge; other site
760568006304	sequence-specific DNA binding site [nucleotide binding]; other site
760568006305	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568006306	non-specific DNA binding site [nucleotide binding]; other site
760568006307	salt bridge; other site
760568006308	sequence-specific DNA binding site [nucleotide binding]; other site
760568006309	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568006310	non-specific DNA binding site [nucleotide binding]; other site
760568006311	salt bridge; other site
760568006312	sequence-specific DNA binding site [nucleotide binding]; other site
760568006313	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568006314	non-specific DNA binding site [nucleotide binding]; other site
760568006315	salt bridge; other site
760568006316	sequence-specific DNA binding site [nucleotide binding]; other site
760568006317	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
760568006318	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568006319	non-specific DNA binding site [nucleotide binding]; other site
760568006320	salt bridge; other site
760568006321	sequence-specific DNA binding site [nucleotide binding]; other site
760568006322	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568006323	non-specific DNA binding site [nucleotide binding]; other site
760568006324	salt bridge; other site
760568006325	sequence-specific DNA binding site [nucleotide binding]; other site
760568006326	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
760568006327	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568006328	non-specific DNA binding site [nucleotide binding]; other site
760568006329	salt bridge; other site
760568006330	sequence-specific DNA binding site [nucleotide binding]; other site
760568006331	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568006332	non-specific DNA binding site [nucleotide binding]; other site
760568006333	salt bridge; other site
760568006334	sequence-specific DNA binding site [nucleotide binding]; other site
760568006335	Protein of unknown function (DUF1664); Region: DUF1664; pfam07889
760568006336	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568006337	salt bridge; other site
760568006338	non-specific DNA binding site [nucleotide binding]; other site
760568006339	sequence-specific DNA binding site [nucleotide binding]; other site
760568006340	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
760568006341	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568006342	non-specific DNA binding site [nucleotide binding]; other site
760568006343	salt bridge; other site
760568006344	sequence-specific DNA binding site [nucleotide binding]; other site
760568006345	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568006346	non-specific DNA binding site [nucleotide binding]; other site
760568006347	salt bridge; other site
760568006348	sequence-specific DNA binding site [nucleotide binding]; other site
760568006349	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
760568006350	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568006351	non-specific DNA binding site [nucleotide binding]; other site
760568006352	salt bridge; other site
760568006353	sequence-specific DNA binding site [nucleotide binding]; other site
760568006354	Creatinine amidohydrolase; Region: Creatininase; pfam02633
760568006355	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
760568006356	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
760568006357	DNA-binding site [nucleotide binding]; DNA binding site
760568006358	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
760568006359	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
760568006360	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
760568006361	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568006362	non-specific DNA binding site [nucleotide binding]; other site
760568006363	salt bridge; other site
760568006364	sequence-specific DNA binding site [nucleotide binding]; other site
760568006365	Domain of unknown function (DUF955); Region: DUF955; pfam06114
760568006366	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
760568006367	Transposase, Mutator family; Region: Transposase_mut; pfam00872
760568006368	MULE transposase domain; Region: MULE; pfam10551
760568006369	Helix-turn-helix domain; Region: HTH_36; pfam13730
760568006370	Domain of unknown function (DUF4338); Region: DUF4338; pfam14236
760568006371	AAA-like domain; Region: AAA_10; pfam12846
760568006372	Domain of unknown function DUF87; Region: DUF87; pfam01935
760568006373	Zonular occludens toxin (Zot); Region: Zot; cl17485
760568006374	NurA nuclease; Region: NurA; smart00933
760568006375	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
760568006376	active site
760568006377	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
760568006378	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
760568006379	DNA-binding site [nucleotide binding]; DNA binding site
760568006380	UTRA domain; Region: UTRA; pfam07702
760568006381	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
760568006382	4Fe-4S binding domain; Region: Fer4_6; pfam12837
760568006383	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
760568006384	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
760568006385	dimer interface [polypeptide binding]; other site
760568006386	active site
760568006387	glycine loop; other site
760568006388	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
760568006389	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
760568006390	NAD(P) binding site [chemical binding]; other site
760568006391	active site
760568006392	benzoate transport; Region: 2A0115; TIGR00895
760568006393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568006394	putative substrate translocation pore; other site
760568006395	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568006396	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
760568006397	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
760568006398	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
760568006399	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
760568006400	dihydrodipicolinate synthase; Region: dapA; TIGR00674
760568006401	dimer interface [polypeptide binding]; other site
760568006402	active site
760568006403	catalytic residue [active]
760568006404	aspartate kinase I; Reviewed; Region: PRK08210
760568006405	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
760568006406	nucleotide binding site [chemical binding]; other site
760568006407	substrate binding site [chemical binding]; other site
760568006408	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
760568006409	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
760568006410	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
760568006411	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
760568006412	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
760568006413	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
760568006414	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
760568006415	NAD binding site [chemical binding]; other site
760568006416	dihydrodipicolinate reductase; Provisional; Region: PRK00048
760568006417	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
760568006418	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
760568006419	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
760568006420	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
760568006421	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
760568006422	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
760568006423	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
760568006424	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
760568006425	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
760568006426	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
760568006427	NodB motif; other site
760568006428	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
760568006429	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
760568006430	RNase E interface [polypeptide binding]; other site
760568006431	trimer interface [polypeptide binding]; other site
760568006432	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
760568006433	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
760568006434	RNase E interface [polypeptide binding]; other site
760568006435	trimer interface [polypeptide binding]; other site
760568006436	active site
760568006437	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
760568006438	putative nucleic acid binding region [nucleotide binding]; other site
760568006439	G-X-X-G motif; other site
760568006440	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
760568006441	RNA binding site [nucleotide binding]; other site
760568006442	domain interface; other site
760568006443	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
760568006444	16S/18S rRNA binding site [nucleotide binding]; other site
760568006445	S13e-L30e interaction site [polypeptide binding]; other site
760568006446	25S rRNA binding site [nucleotide binding]; other site
760568006447	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
760568006448	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
760568006449	active site
760568006450	Riboflavin kinase; Region: Flavokinase; pfam01687
760568006451	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
760568006452	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
760568006453	RNA binding site [nucleotide binding]; other site
760568006454	active site
760568006455	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
760568006456	DHH family; Region: DHH; pfam01368
760568006457	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
760568006458	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
760568006459	translation initiation factor IF-2; Validated; Region: infB; PRK05306
760568006460	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
760568006461	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
760568006462	G1 box; other site
760568006463	putative GEF interaction site [polypeptide binding]; other site
760568006464	GTP/Mg2+ binding site [chemical binding]; other site
760568006465	Switch I region; other site
760568006466	G2 box; other site
760568006467	G3 box; other site
760568006468	Switch II region; other site
760568006469	G4 box; other site
760568006470	G5 box; other site
760568006471	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
760568006472	Translation-initiation factor 2; Region: IF-2; pfam11987
760568006473	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
760568006474	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
760568006475	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
760568006476	putative RNA binding cleft [nucleotide binding]; other site
760568006477	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
760568006478	NusA N-terminal domain; Region: NusA_N; pfam08529
760568006479	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
760568006480	RNA binding site [nucleotide binding]; other site
760568006481	homodimer interface [polypeptide binding]; other site
760568006482	NusA-like KH domain; Region: KH_5; pfam13184
760568006483	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
760568006484	G-X-X-G motif; other site
760568006485	ribosome maturation protein RimP; Reviewed; Region: PRK00092
760568006486	Sm and related proteins; Region: Sm_like; cl00259
760568006487	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
760568006488	putative oligomer interface [polypeptide binding]; other site
760568006489	putative RNA binding site [nucleotide binding]; other site
760568006490	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
760568006491	MgtC family; Region: MgtC; pfam02308
760568006492	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
760568006493	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
760568006494	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
760568006495	prolyl-tRNA synthetase; Provisional; Region: PRK09194
760568006496	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
760568006497	dimer interface [polypeptide binding]; other site
760568006498	motif 1; other site
760568006499	active site
760568006500	motif 2; other site
760568006501	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
760568006502	putative deacylase active site [active]
760568006503	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
760568006504	active site
760568006505	motif 3; other site
760568006506	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
760568006507	anticodon binding site; other site
760568006508	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
760568006509	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
760568006510	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
760568006511	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
760568006512	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
760568006513	active site
760568006514	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
760568006515	protein binding site [polypeptide binding]; other site
760568006516	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
760568006517	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
760568006518	putative substrate binding region [chemical binding]; other site
760568006519	putative substrate binding region [chemical binding]; other site
760568006520	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
760568006521	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
760568006522	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
760568006523	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
760568006524	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
760568006525	Domain of unknown function DUF20; Region: UPF0118; pfam01594
760568006526	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
760568006527	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
760568006528	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
760568006529	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
760568006530	catalytic residue [active]
760568006531	putative FPP diphosphate  binding site; other site
760568006532	putative FPP binding hydrophobic cleft; other site
760568006533	dimer interface [polypeptide binding]; other site
760568006534	putative IPP diphosphate binding site; other site
760568006535	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
760568006536	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568006537	ribosome recycling factor; Reviewed; Region: frr; PRK00083
760568006538	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
760568006539	hinge region; other site
760568006540	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
760568006541	putative nucleotide binding site [chemical binding]; other site
760568006542	uridine monophosphate binding site [chemical binding]; other site
760568006543	homohexameric interface [polypeptide binding]; other site
760568006544	elongation factor Ts; Reviewed; Region: tsf; PRK12332
760568006545	UBA/TS-N domain; Region: UBA; pfam00627
760568006546	Elongation factor TS; Region: EF_TS; pfam00889
760568006547	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
760568006548	rRNA interaction site [nucleotide binding]; other site
760568006549	S8 interaction site; other site
760568006550	putative laminin-1 binding site; other site
760568006551	Predicted methyltransferases [General function prediction only]; Region: COG1568
760568006552	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568006553	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568006554	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
760568006555	putative active site [active]
760568006556	heme pocket [chemical binding]; other site
760568006557	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
760568006558	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568006559	putative active site [active]
760568006560	heme pocket [chemical binding]; other site
760568006561	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
760568006562	dimer interface [polypeptide binding]; other site
760568006563	phosphorylation site [posttranslational modification]
760568006564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568006565	ATP binding site [chemical binding]; other site
760568006566	Mg2+ binding site [ion binding]; other site
760568006567	G-X-G motif; other site
760568006568	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
760568006569	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
760568006570	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
760568006571	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
760568006572	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
760568006573	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
760568006574	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
760568006575	HAMP domain; Region: HAMP; pfam00672
760568006576	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
760568006577	dimer interface [polypeptide binding]; other site
760568006578	phosphorylation site [posttranslational modification]
760568006579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568006580	ATP binding site [chemical binding]; other site
760568006581	Mg2+ binding site [ion binding]; other site
760568006582	G-X-G motif; other site
760568006583	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
760568006584	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568006585	active site
760568006586	phosphorylation site [posttranslational modification]
760568006587	intermolecular recognition site; other site
760568006588	dimerization interface [polypeptide binding]; other site
760568006589	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568006590	Walker A motif; other site
760568006591	ATP binding site [chemical binding]; other site
760568006592	Walker B motif; other site
760568006593	arginine finger; other site
760568006594	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
760568006595	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
760568006596	Coenzyme A binding pocket [chemical binding]; other site
760568006597	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568006598	active site
760568006599	NTP binding site [chemical binding]; other site
760568006600	metal binding triad [ion binding]; metal-binding site
760568006601	antibiotic binding site [chemical binding]; other site
760568006602	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
760568006603	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
760568006604	trimer interface [polypeptide binding]; other site
760568006605	putative metal binding site [ion binding]; other site
760568006606	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568006607	ATP binding site [chemical binding]; other site
760568006608	Mg2+ binding site [ion binding]; other site
760568006609	G-X-G motif; other site
760568006610	Accessory gene regulator B; Region: AgrB; pfam04647
760568006611	cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223
760568006612	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
760568006613	nucleotide binding region [chemical binding]; other site
760568006614	ATP-binding site [chemical binding]; other site
760568006615	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
760568006616	DEAD-like helicases superfamily; Region: DEXDc; smart00487
760568006617	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
760568006618	ATP binding site [chemical binding]; other site
760568006619	putative Mg++ binding site [ion binding]; other site
760568006620	Predicted integral membrane protein [Function unknown]; Region: COG5542
760568006621	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
760568006622	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
760568006623	Ligand binding site; other site
760568006624	Putative Catalytic site; other site
760568006625	DXD motif; other site
760568006626	Predicted membrane protein [Function unknown]; Region: COG2246
760568006627	GtrA-like protein; Region: GtrA; pfam04138
760568006628	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
760568006629	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
760568006630	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
760568006631	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
760568006632	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
760568006633	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
760568006634	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
760568006635	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
760568006636	Walker A/P-loop; other site
760568006637	ATP binding site [chemical binding]; other site
760568006638	Q-loop/lid; other site
760568006639	ABC transporter signature motif; other site
760568006640	Walker B; other site
760568006641	D-loop; other site
760568006642	H-loop/switch region; other site
760568006643	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
760568006644	dimer interface [polypeptide binding]; other site
760568006645	conserved gate region; other site
760568006646	putative PBP binding loops; other site
760568006647	ABC-ATPase subunit interface; other site
760568006648	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
760568006649	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
760568006650	substrate binding pocket [chemical binding]; other site
760568006651	membrane-bound complex binding site; other site
760568006652	hinge residues; other site
760568006653	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
760568006654	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
760568006655	Coenzyme A binding pocket [chemical binding]; other site
760568006656	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
760568006657	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568006658	FeS/SAM binding site; other site
760568006659	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
760568006660	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
760568006661	Uncharacterized conserved protein [Function unknown]; Region: COG0327
760568006662	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
760568006663	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
760568006664	Uncharacterized conserved protein [Function unknown]; Region: COG0327
760568006665	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
760568006666	Family of unknown function (DUF633); Region: DUF633; pfam04816
760568006667	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
760568006668	DctM-like transporters; Region: DctM; pfam06808
760568006669	Domain of unknown function (DUF1850); Region: DUF1850; pfam08905
760568006670	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
760568006671	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
760568006672	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
760568006673	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
760568006674	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
760568006675	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
760568006676	Ligand binding site [chemical binding]; other site
760568006677	Electron transfer flavoprotein domain; Region: ETF; pfam01012
760568006678	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
760568006679	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
760568006680	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
760568006681	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
760568006682	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
760568006683	active site
760568006684	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
760568006685	Transcriptional regulator [Transcription]; Region: IclR; COG1414
760568006686	Bacterial transcriptional regulator; Region: IclR; pfam01614
760568006687	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
760568006688	CoA-transferase family III; Region: CoA_transf_3; pfam02515
760568006689	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
760568006690	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
760568006691	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
760568006692	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
760568006693	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
760568006694	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
760568006695	DNA binding residues [nucleotide binding]
760568006696	DNA primase; Validated; Region: dnaG; PRK05667
760568006697	CHC2 zinc finger; Region: zf-CHC2; pfam01807
760568006698	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
760568006699	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
760568006700	active site
760568006701	metal binding site [ion binding]; metal-binding site
760568006702	interdomain interaction site; other site
760568006703	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
760568006704	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
760568006705	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568006706	Zn2+ binding site [ion binding]; other site
760568006707	Mg2+ binding site [ion binding]; other site
760568006708	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
760568006709	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
760568006710	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
760568006711	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
760568006712	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
760568006713	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
760568006714	PAS fold; Region: PAS; pfam00989
760568006715	PAS domain; Region: PAS; smart00091
760568006716	putative active site [active]
760568006717	heme pocket [chemical binding]; other site
760568006718	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
760568006719	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568006720	Zn2+ binding site [ion binding]; other site
760568006721	Mg2+ binding site [ion binding]; other site
760568006722	pyruvate phosphate dikinase; Provisional; Region: PRK09279
760568006723	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
760568006724	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
760568006725	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
760568006726	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
760568006727	HTH domain; Region: HTH_11; pfam08279
760568006728	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
760568006729	FOG: CBS domain [General function prediction only]; Region: COG0517
760568006730	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
760568006731	DALR anticodon binding domain; Region: DALR_1; pfam05746
760568006732	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
760568006733	dimer interface [polypeptide binding]; other site
760568006734	motif 1; other site
760568006735	active site
760568006736	motif 2; other site
760568006737	motif 3; other site
760568006738	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
760568006739	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
760568006740	Recombination protein O N terminal; Region: RecO_N; pfam11967
760568006741	Recombination protein O C terminal; Region: RecO_C; pfam02565
760568006742	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
760568006743	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
760568006744	active site
760568006745	metal binding site [ion binding]; metal-binding site
760568006746	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
760568006747	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
760568006748	active site
760568006749	metal binding site [ion binding]; metal-binding site
760568006750	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
760568006751	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
760568006752	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
760568006753	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
760568006754	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
760568006755	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
760568006756	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
760568006757	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849
760568006758	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
760568006759	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
760568006760	Flavoprotein; Region: Flavoprotein; pfam02441
760568006761	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
760568006762	MgtE intracellular N domain; Region: MgtE_N; smart00924
760568006763	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
760568006764	Divalent cation transporter; Region: MgtE; pfam01769
760568006765	GTPase Era; Reviewed; Region: era; PRK00089
760568006766	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
760568006767	G1 box; other site
760568006768	GTP/Mg2+ binding site [chemical binding]; other site
760568006769	Switch I region; other site
760568006770	G2 box; other site
760568006771	Switch II region; other site
760568006772	G3 box; other site
760568006773	G4 box; other site
760568006774	G5 box; other site
760568006775	KH domain; Region: KH_2; pfam07650
760568006776	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
760568006777	active site
760568006778	catalytic motif [active]
760568006779	Zn binding site [ion binding]; other site
760568006780	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
760568006781	metal-binding heat shock protein; Provisional; Region: PRK00016
760568006782	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
760568006783	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
760568006784	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568006785	Zn2+ binding site [ion binding]; other site
760568006786	Mg2+ binding site [ion binding]; other site
760568006787	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
760568006788	PhoH-like protein; Region: PhoH; pfam02562
760568006789	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
760568006790	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
760568006791	YabP family; Region: YabP; cl06766
760568006792	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
760568006793	selenophosphate synthetase; Provisional; Region: PRK00943
760568006794	dimerization interface [polypeptide binding]; other site
760568006795	putative ATP binding site [chemical binding]; other site
760568006796	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
760568006797	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
760568006798	CPxP  motif; other site
760568006799	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
760568006800	putative homodimer interface [polypeptide binding]; other site
760568006801	putative homotetramer interface [polypeptide binding]; other site
760568006802	putative allosteric switch controlling residues; other site
760568006803	putative metal binding site [ion binding]; other site
760568006804	putative homodimer-homodimer interface [polypeptide binding]; other site
760568006805	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
760568006806	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
760568006807	metal-binding site [ion binding]
760568006808	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
760568006809	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
760568006810	metal-binding site [ion binding]
760568006811	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
760568006812	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
760568006813	motif II; other site
760568006814	Protein of unknown function (DUF1624); Region: DUF1624; pfam07786
760568006815	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
760568006816	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
760568006817	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
760568006818	Ligand Binding Site [chemical binding]; other site
760568006819	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568006820	putative substrate translocation pore; other site
760568006821	Major Facilitator Superfamily; Region: MFS_1; pfam07690
760568006822	Archaeal ATPase; Region: Arch_ATPase; pfam01637
760568006823	AAA ATPase domain; Region: AAA_16; pfam13191
760568006824	hypothetical protein; Provisional; Region: PRK13665
760568006825	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
760568006826	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
760568006827	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
760568006828	nucleotide binding site/active site [active]
760568006829	HIT family signature motif; other site
760568006830	catalytic residue [active]
760568006831	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
760568006832	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
760568006833	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568006834	FeS/SAM binding site; other site
760568006835	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
760568006836	RNA methyltransferase, RsmE family; Region: TIGR00046
760568006837	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
760568006838	chaperone protein DnaJ; Provisional; Region: PRK10767
760568006839	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
760568006840	HSP70 interaction site [polypeptide binding]; other site
760568006841	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
760568006842	substrate binding site [polypeptide binding]; other site
760568006843	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
760568006844	Zn binding sites [ion binding]; other site
760568006845	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
760568006846	dimer interface [polypeptide binding]; other site
760568006847	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
760568006848	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
760568006849	nucleotide binding site [chemical binding]; other site
760568006850	NEF interaction site [polypeptide binding]; other site
760568006851	SBD interface [polypeptide binding]; other site
760568006852	GrpE; Region: GrpE; pfam01025
760568006853	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
760568006854	dimer interface [polypeptide binding]; other site
760568006855	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
760568006856	chaperonin families, type I and type II. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The...; Region: chaperonin_type_I_II; cd00309
760568006857	thermosome, various subunits, archaeal; Region: thermosome_arch; TIGR02339
760568006858	ATP/Mg binding site [chemical binding]; other site
760568006859	ring oligomerisation interface [polypeptide binding]; other site
760568006860	hinge regions; other site
760568006861	stacking interactions; other site
760568006862	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
760568006863	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
760568006864	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
760568006865	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568006866	FeS/SAM binding site; other site
760568006867	HemN C-terminal domain; Region: HemN_C; pfam06969
760568006868	GTP-binding protein LepA; Provisional; Region: PRK05433
760568006869	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
760568006870	G1 box; other site
760568006871	putative GEF interaction site [polypeptide binding]; other site
760568006872	GTP/Mg2+ binding site [chemical binding]; other site
760568006873	Switch I region; other site
760568006874	G2 box; other site
760568006875	G3 box; other site
760568006876	Switch II region; other site
760568006877	G4 box; other site
760568006878	G5 box; other site
760568006879	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
760568006880	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
760568006881	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
760568006882	HPP family; Region: HPP; pfam04982
760568006883	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
760568006884	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568006885	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
760568006886	stage II sporulation protein P; Region: spore_II_P; TIGR02867
760568006887	Membrane protein of unknown function; Region: DUF360; pfam04020
760568006888	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
760568006889	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
760568006890	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
760568006891	Domain of unknown function DUF77; Region: DUF77; pfam01910
760568006892	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
760568006893	Walker A motif; other site
760568006894	MOSC domain; Region: MOSC; pfam03473
760568006895	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
760568006896	trimer interface [polypeptide binding]; other site
760568006897	dimer interface [polypeptide binding]; other site
760568006898	putative active site [active]
760568006899	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
760568006900	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568006901	FeS/SAM binding site; other site
760568006902	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
760568006903	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
760568006904	catalytic loop [active]
760568006905	iron binding site [ion binding]; other site
760568006906	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
760568006907	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568006908	Ferredoxin [Energy production and conversion]; Region: NapF; COG1145
760568006909	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
760568006910	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
760568006911	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
760568006912	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
760568006913	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
760568006914	Glutamate binding site [chemical binding]; other site
760568006915	homodimer interface [polypeptide binding]; other site
760568006916	NAD binding site [chemical binding]; other site
760568006917	catalytic residues [active]
760568006918	GAF domain; Region: GAF; cl17456
760568006919	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568006920	PAS domain; Region: PAS_9; pfam13426
760568006921	putative active site [active]
760568006922	heme pocket [chemical binding]; other site
760568006923	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
760568006924	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568006925	Walker A motif; other site
760568006926	ATP binding site [chemical binding]; other site
760568006927	Walker B motif; other site
760568006928	arginine finger; other site
760568006929	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
760568006930	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
760568006931	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568006932	putative active site [active]
760568006933	heme pocket [chemical binding]; other site
760568006934	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568006935	Walker A motif; other site
760568006936	ATP binding site [chemical binding]; other site
760568006937	Walker B motif; other site
760568006938	arginine finger; other site
760568006939	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
760568006940	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
760568006941	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
760568006942	Walker A/P-loop; other site
760568006943	ATP binding site [chemical binding]; other site
760568006944	Q-loop/lid; other site
760568006945	ABC transporter signature motif; other site
760568006946	Walker B; other site
760568006947	D-loop; other site
760568006948	H-loop/switch region; other site
760568006949	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
760568006950	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
760568006951	Walker A/P-loop; other site
760568006952	ATP binding site [chemical binding]; other site
760568006953	Q-loop/lid; other site
760568006954	ABC transporter signature motif; other site
760568006955	Walker B; other site
760568006956	D-loop; other site
760568006957	H-loop/switch region; other site
760568006958	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
760568006959	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
760568006960	TM-ABC transporter signature motif; other site
760568006961	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
760568006962	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
760568006963	TM-ABC transporter signature motif; other site
760568006964	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
760568006965	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
760568006966	putative ligand binding site [chemical binding]; other site
760568006967	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
760568006968	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
760568006969	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
760568006970	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
760568006971	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
760568006972	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
760568006973	dimerization interface [polypeptide binding]; other site
760568006974	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
760568006975	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
760568006976	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
760568006977	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
760568006978	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
760568006979	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
760568006980	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
760568006981	ATP binding site [chemical binding]; other site
760568006982	Walker A motif; other site
760568006983	hexamer interface [polypeptide binding]; other site
760568006984	Walker B motif; other site
760568006985	Response regulator receiver domain; Region: Response_reg; pfam00072
760568006986	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568006987	active site
760568006988	phosphorylation site [posttranslational modification]
760568006989	intermolecular recognition site; other site
760568006990	dimerization interface [polypeptide binding]; other site
760568006991	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
760568006992	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
760568006993	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
760568006994	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
760568006995	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
760568006996	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
760568006997	TadE-like protein; Region: TadE; pfam07811
760568006998	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
760568006999	Flp/Fap pilin component; Region: Flp_Fap; cl01585
760568007000	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
760568007001	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568007002	active site
760568007003	phosphorylation site [posttranslational modification]
760568007004	intermolecular recognition site; other site
760568007005	dimerization interface [polypeptide binding]; other site
760568007006	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
760568007007	DNA binding residues [nucleotide binding]
760568007008	dimerization interface [polypeptide binding]; other site
760568007009	Sensor protein DegS; Region: DegS; pfam05384
760568007010	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
760568007011	Histidine kinase; Region: HisKA_3; pfam07730
760568007012	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568007013	ATP binding site [chemical binding]; other site
760568007014	Mg2+ binding site [ion binding]; other site
760568007015	G-X-G motif; other site
760568007016	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
760568007017	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
760568007018	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
760568007019	catalytic loop [active]
760568007020	iron binding site [ion binding]; other site
760568007021	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
760568007022	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
760568007023	B12 binding site [chemical binding]; other site
760568007024	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
760568007025	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
760568007026	DNA-binding site [nucleotide binding]; DNA binding site
760568007027	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
760568007028	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
760568007029	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
760568007030	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
760568007031	substrate binding pocket [chemical binding]; other site
760568007032	dimer interface [polypeptide binding]; other site
760568007033	inhibitor binding site; inhibition site
760568007034	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
760568007035	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
760568007036	B12 binding site [chemical binding]; other site
760568007037	cobalt ligand [ion binding]; other site
760568007038	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
760568007039	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568007040	Major Facilitator Superfamily; Region: MFS_1; pfam07690
760568007041	putative substrate translocation pore; other site
760568007042	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
760568007043	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
760568007044	putative active site [active]
760568007045	Predicted amidohydrolase [General function prediction only]; Region: COG0388
760568007046	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
760568007047	active site
760568007048	catalytic triad [active]
760568007049	dimer interface [polypeptide binding]; other site
760568007050	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568007051	4Fe-4S binding domain; Region: Fer4; pfam00037
760568007052	Transcriptional regulators [Transcription]; Region: MarR; COG1846
760568007053	MarR family; Region: MarR; pfam01047
760568007054	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
760568007055	CHC2 zinc finger; Region: zf-CHC2; cl17510
760568007056	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
760568007057	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
760568007058	Helix-turn-helix domain; Region: HTH_17; pfam12728
760568007059	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
760568007060	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
760568007061	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
760568007062	Predicted GTPase [General function prediction only]; Region: DRG; COG1163
760568007063	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
760568007064	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
760568007065	G1 box; other site
760568007066	G1 box; other site
760568007067	GTP/Mg2+ binding site [chemical binding]; other site
760568007068	GTP/Mg2+ binding site [chemical binding]; other site
760568007069	G2 box; other site
760568007070	Switch I region; other site
760568007071	G3 box; other site
760568007072	Switch II region; other site
760568007073	G4 box; other site
760568007074	G5 box; other site
760568007075	TGS_DRG_C:   DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it...; Region: TGS_DRG_C; cd01666
760568007076	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
760568007077	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
760568007078	DNA binding residues [nucleotide binding]
760568007079	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
760568007080	catalytic residues [active]
760568007081	catalytic nucleophile [active]
760568007082	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
760568007083	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
760568007084	Competence protein; Region: Competence; pfam03772
760568007085	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
760568007086	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
760568007087	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
760568007088	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
760568007089	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
760568007090	N-acetyl-D-glucosamine binding site [chemical binding]; other site
760568007091	catalytic residue [active]
760568007092	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
760568007093	SLBB domain; Region: SLBB; pfam10531
760568007094	Helix-hairpin-helix motif; Region: HHH; pfam00633
760568007095	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
760568007096	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
760568007097	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
760568007098	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568007099	Walker A/P-loop; other site
760568007100	ATP binding site [chemical binding]; other site
760568007101	Q-loop/lid; other site
760568007102	ABC transporter signature motif; other site
760568007103	Walker B; other site
760568007104	D-loop; other site
760568007105	H-loop/switch region; other site
760568007106	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
760568007107	dimer interface [polypeptide binding]; other site
760568007108	conserved gate region; other site
760568007109	putative PBP binding loops; other site
760568007110	ABC-ATPase subunit interface; other site
760568007111	Predicted membrane protein [Function unknown]; Region: COG2323
760568007112	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
760568007113	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
760568007114	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
760568007115	dimerization interface [polypeptide binding]; other site
760568007116	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
760568007117	dimer interface [polypeptide binding]; other site
760568007118	putative CheW interface [polypeptide binding]; other site
760568007119	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
760568007120	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
760568007121	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
760568007122	4Fe-4S binding domain; Region: Fer4; pfam00037
760568007123	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
760568007124	dimer interface [polypeptide binding]; other site
760568007125	putative CheW interface [polypeptide binding]; other site
760568007126	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
760568007127	4Fe-4S binding domain; Region: Fer4; cl02805
760568007128	thiosulfate reductase PhsA; Provisional; Region: PRK15488
760568007129	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
760568007130	putative [Fe4-S4] binding site [ion binding]; other site
760568007131	putative molybdopterin cofactor binding site [chemical binding]; other site
760568007132	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
760568007133	putative molybdopterin cofactor binding site; other site
760568007134	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
760568007135	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
760568007136	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
760568007137	ligand binding site [chemical binding]; other site
760568007138	flexible hinge region; other site
760568007139	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
760568007140	putative switch regulator; other site
760568007141	non-specific DNA interactions [nucleotide binding]; other site
760568007142	DNA binding site [nucleotide binding]
760568007143	sequence specific DNA binding site [nucleotide binding]; other site
760568007144	putative cAMP binding site [chemical binding]; other site
760568007145	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
760568007146	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
760568007147	FMN binding site [chemical binding]; other site
760568007148	dimer interface [polypeptide binding]; other site
760568007149	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
760568007150	Ligand Binding Site [chemical binding]; other site
760568007151	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
760568007152	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
760568007153	transmembrane helices; other site
760568007154	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
760568007155	intersubunit interface [polypeptide binding]; other site
760568007156	active site
760568007157	catalytic residue [active]
760568007158	Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792
760568007159	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
760568007160	Cytochrome c552; Region: Cytochrom_C552; pfam02335
760568007161	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
760568007162	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
760568007163	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
760568007164	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
760568007165	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
760568007166	ResB-like family; Region: ResB; pfam05140
760568007167	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
760568007168	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568007169	active site
760568007170	phosphorylation site [posttranslational modification]
760568007171	intermolecular recognition site; other site
760568007172	dimerization interface [polypeptide binding]; other site
760568007173	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
760568007174	DNA binding site [nucleotide binding]
760568007175	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
760568007176	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
760568007177	dimerization interface [polypeptide binding]; other site
760568007178	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
760568007179	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
760568007180	dimer interface [polypeptide binding]; other site
760568007181	phosphorylation site [posttranslational modification]
760568007182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568007183	ATP binding site [chemical binding]; other site
760568007184	Mg2+ binding site [ion binding]; other site
760568007185	G-X-G motif; other site
760568007186	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
760568007187	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
760568007188	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
760568007189	motif II; other site
760568007190	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
760568007191	metal-binding site [ion binding]
760568007192	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
760568007193	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
760568007194	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
760568007195	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
760568007196	HlyD family secretion protein; Region: HlyD_3; pfam13437
760568007197	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
760568007198	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
760568007199	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
760568007200	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
760568007201	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
760568007202	ligand binding site [chemical binding]; other site
760568007203	flexible hinge region; other site
760568007204	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
760568007205	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
760568007206	cell division protein FtsA; Region: ftsA; TIGR01174
760568007207	Cell division protein FtsA; Region: FtsA; smart00842
760568007208	Cell division protein FtsA; Region: FtsA; pfam14450
760568007209	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
760568007210	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
760568007211	dimer interface [polypeptide binding]; other site
760568007212	putative CheW interface [polypeptide binding]; other site
760568007213	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
760568007214	heme-binding site [chemical binding]; other site
760568007215	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
760568007216	putative CheW interface [polypeptide binding]; other site
760568007217	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
760568007218	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568007219	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
760568007220	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
760568007221	putative ligand binding site [chemical binding]; other site
760568007222	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
760568007223	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
760568007224	ACS interaction site; other site
760568007225	CODH interaction site; other site
760568007226	Prismane/CO dehydrogenase family; Region: Prismane; pfam03063
760568007227	cubane metal cluster (B-cluster) [ion binding]; other site
760568007228	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
760568007229	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
760568007230	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
760568007231	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568007232	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
760568007233	S-layer homology domain; Region: SLH; pfam00395
760568007234	S-layer homology domain; Region: SLH; pfam00395
760568007235	S-layer homology domain; Region: SLH; pfam00395
760568007236	FecR protein; Region: FecR; pfam04773
760568007237	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
760568007238	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
760568007239	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
760568007240	cyclase homology domain; Region: CHD; cd07302
760568007241	nucleotidyl binding site; other site
760568007242	metal binding site [ion binding]; metal-binding site
760568007243	dimer interface [polypeptide binding]; other site
760568007244	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
760568007245	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
760568007246	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
760568007247	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
760568007248	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568007249	Zn2+ binding site [ion binding]; other site
760568007250	Mg2+ binding site [ion binding]; other site
760568007251	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
760568007252	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568007253	ATP binding site [chemical binding]; other site
760568007254	Mg2+ binding site [ion binding]; other site
760568007255	G-X-G motif; other site
760568007256	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
760568007257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568007258	active site
760568007259	phosphorylation site [posttranslational modification]
760568007260	intermolecular recognition site; other site
760568007261	dimerization interface [polypeptide binding]; other site
760568007262	LytTr DNA-binding domain; Region: LytTR; smart00850
760568007263	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
760568007264	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
760568007265	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
760568007266	active site
760568007267	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568007268	Zn2+ binding site [ion binding]; other site
760568007269	Mg2+ binding site [ion binding]; other site
760568007270	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
760568007271	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568007272	Zn2+ binding site [ion binding]; other site
760568007273	Mg2+ binding site [ion binding]; other site
760568007274	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
760568007275	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
760568007276	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568007277	catalytic residue [active]
760568007278	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
760568007279	putative homodimer interface [polypeptide binding]; other site
760568007280	putative active site pocket [active]
760568007281	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
760568007282	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
760568007283	active site
760568007284	substrate binding site [chemical binding]; other site
760568007285	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
760568007286	FMN binding site [chemical binding]; other site
760568007287	putative catalytic residues [active]
760568007288	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
760568007289	nucleotide binding site/active site [active]
760568007290	HIT family signature motif; other site
760568007291	catalytic residue [active]
760568007292	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
760568007293	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
760568007294	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
760568007295	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
760568007296	putative NAD(P) binding site [chemical binding]; other site
760568007297	active site
760568007298	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
760568007299	metal ion-dependent adhesion site (MIDAS); other site
760568007300	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
760568007301	metal ion-dependent adhesion site (MIDAS); other site
760568007302	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
760568007303	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
760568007304	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
760568007305	metal ion-dependent adhesion site (MIDAS); other site
760568007306	Protein of unknown function DUF58; Region: DUF58; pfam01882
760568007307	MoxR-like ATPases [General function prediction only]; Region: COG0714
760568007308	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568007309	Walker A motif; other site
760568007310	ATP binding site [chemical binding]; other site
760568007311	Walker B motif; other site
760568007312	arginine finger; other site
760568007313	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
760568007314	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568007315	active site
760568007316	phosphorylation site [posttranslational modification]
760568007317	intermolecular recognition site; other site
760568007318	dimerization interface [polypeptide binding]; other site
760568007319	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
760568007320	DNA binding site [nucleotide binding]
760568007321	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
760568007322	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
760568007323	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
760568007324	DNA binding residues [nucleotide binding]
760568007325	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
760568007326	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
760568007327	dimerization interface [polypeptide binding]; other site
760568007328	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
760568007329	dimer interface [polypeptide binding]; other site
760568007330	phosphorylation site [posttranslational modification]
760568007331	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568007332	ATP binding site [chemical binding]; other site
760568007333	Mg2+ binding site [ion binding]; other site
760568007334	G-X-G motif; other site
760568007335	Family description; Region: VCBS; pfam13517
760568007336	Tetratricopeptide repeat; Region: TPR_2; pfam07719
760568007337	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568007338	active site
760568007339	NTP binding site [chemical binding]; other site
760568007340	metal binding triad [ion binding]; metal-binding site
760568007341	antibiotic binding site [chemical binding]; other site
760568007342	HEPN domain; Region: HEPN; cl00824
760568007343	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
760568007344	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
760568007345	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
760568007346	DNA binding residues [nucleotide binding]
760568007347	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
760568007348	catalytic residues [active]
760568007349	catalytic nucleophile [active]
760568007350	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
760568007351	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
760568007352	Walker A/P-loop; other site
760568007353	ATP binding site [chemical binding]; other site
760568007354	Q-loop/lid; other site
760568007355	ABC transporter signature motif; other site
760568007356	Walker B; other site
760568007357	D-loop; other site
760568007358	H-loop/switch region; other site
760568007359	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
760568007360	Protein of unknown function (DUF1392); Region: DUF1392; pfam07154
760568007361	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
760568007362	Divergent AAA domain; Region: AAA_4; pfam04326
760568007363	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
760568007364	PrcB C-terminal; Region: PrcB_C; pfam14343
760568007365	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
760568007366	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
760568007367	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
760568007368	DNA binding residues [nucleotide binding]
760568007369	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
760568007370	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
760568007371	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
760568007372	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
760568007373	Walker A/P-loop; other site
760568007374	ATP binding site [chemical binding]; other site
760568007375	Q-loop/lid; other site
760568007376	ABC transporter signature motif; other site
760568007377	Walker B; other site
760568007378	D-loop; other site
760568007379	H-loop/switch region; other site
760568007380	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
760568007381	Accessory gene regulator B; Region: AgrB; pfam04647
760568007382	cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223
760568007383	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
760568007384	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568007385	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568007386	metal binding site [ion binding]; metal-binding site
760568007387	active site
760568007388	I-site; other site
760568007389	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
760568007390	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568007391	Zn2+ binding site [ion binding]; other site
760568007392	Mg2+ binding site [ion binding]; other site
760568007393	Uncharacterized conserved protein [Function unknown]; Region: COG0062
760568007394	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
760568007395	putative substrate binding site [chemical binding]; other site
760568007396	putative ATP binding site [chemical binding]; other site
760568007397	Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736
760568007398	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
760568007399	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568007400	active site
760568007401	phosphorylation site [posttranslational modification]
760568007402	intermolecular recognition site; other site
760568007403	dimerization interface [polypeptide binding]; other site
760568007404	LytTr DNA-binding domain; Region: LytTR; smart00850
760568007405	GAF domain; Region: GAF; pfam01590
760568007406	Histidine kinase; Region: His_kinase; pfam06580
760568007407	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568007408	ATP binding site [chemical binding]; other site
760568007409	Mg2+ binding site [ion binding]; other site
760568007410	G-X-G motif; other site
760568007411	acetyl-CoA synthetase; Provisional; Region: PRK00174
760568007412	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
760568007413	active site
760568007414	CoA binding site [chemical binding]; other site
760568007415	acyl-activating enzyme (AAE) consensus motif; other site
760568007416	AMP binding site [chemical binding]; other site
760568007417	acetate binding site [chemical binding]; other site
760568007418	FOG: CBS domain [General function prediction only]; Region: COG0517
760568007419	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
760568007420	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
760568007421	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
760568007422	FOG: CBS domain [General function prediction only]; Region: COG0517
760568007423	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
760568007424	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568007425	active site
760568007426	phosphorylation site [posttranslational modification]
760568007427	intermolecular recognition site; other site
760568007428	dimerization interface [polypeptide binding]; other site
760568007429	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568007430	Walker A motif; other site
760568007431	ATP binding site [chemical binding]; other site
760568007432	Walker B motif; other site
760568007433	arginine finger; other site
760568007434	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
760568007435	sensory histidine kinase AtoS; Provisional; Region: PRK11360
760568007436	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
760568007437	dimer interface [polypeptide binding]; other site
760568007438	phosphorylation site [posttranslational modification]
760568007439	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568007440	ATP binding site [chemical binding]; other site
760568007441	Mg2+ binding site [ion binding]; other site
760568007442	G-X-G motif; other site
760568007443	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
760568007444	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
760568007445	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
760568007446	catalytic site [active]
760568007447	active site
760568007448	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
760568007449	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
760568007450	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
760568007451	active site
760568007452	catalytic site [active]
760568007453	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
760568007454	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
760568007455	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
760568007456	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
760568007457	active site
760568007458	catalytic site [active]
760568007459	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
760568007460	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
760568007461	acyl-activating enzyme (AAE) consensus motif; other site
760568007462	AMP binding site [chemical binding]; other site
760568007463	active site
760568007464	CoA binding site [chemical binding]; other site
760568007465	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
760568007466	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
760568007467	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
760568007468	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
760568007469	dimer interface [polypeptide binding]; other site
760568007470	PYR/PP interface [polypeptide binding]; other site
760568007471	TPP binding site [chemical binding]; other site
760568007472	substrate binding site [chemical binding]; other site
760568007473	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
760568007474	TPP-binding site; other site
760568007475	4Fe-4S binding domain; Region: Fer4; pfam00037
760568007476	DctM-like transporters; Region: DctM; pfam06808
760568007477	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
760568007478	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
760568007479	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
760568007480	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
760568007481	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
760568007482	RNA binding surface [nucleotide binding]; other site
760568007483	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
760568007484	active site
760568007485	uracil binding [chemical binding]; other site
760568007486	Uncharacterized conserved protein [Function unknown]; Region: COG0585
760568007487	Pseudouridine synthase, a subgroup of the TruD family; Region: PSTD1; cd02577
760568007488	active site
760568007489	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
760568007490	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
760568007491	PIN domain; Region: PIN_3; cl17397
760568007492	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
760568007493	SpoOM protein; Region: Spo0M; pfam07070
760568007494	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
760568007495	putative active site [active]
760568007496	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
760568007497	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
760568007498	Archaeal ATPase; Region: Arch_ATPase; pfam01637
760568007499	AAA ATPase domain; Region: AAA_16; pfam13191
760568007500	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
760568007501	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
760568007502	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
760568007503	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568007504	active site
760568007505	NTP binding site [chemical binding]; other site
760568007506	metal binding triad [ion binding]; metal-binding site
760568007507	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
760568007508	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
760568007509	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
760568007510	putative active site [active]
760568007511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568007512	Walker A motif; other site
760568007513	ATP binding site [chemical binding]; other site
760568007514	Walker B motif; other site
760568007515	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
760568007516	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
760568007517	glutaminase active site [active]
760568007518	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
760568007519	dimer interface [polypeptide binding]; other site
760568007520	active site
760568007521	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
760568007522	dimer interface [polypeptide binding]; other site
760568007523	active site
760568007524	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
760568007525	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
760568007526	active site
760568007527	substrate binding site [chemical binding]; other site
760568007528	metal binding site [ion binding]; metal-binding site
760568007529	YbbR-like protein; Region: YbbR; pfam07949
760568007530	YbbR-like protein; Region: YbbR; pfam07949
760568007531	YbbR-like protein; Region: YbbR; pfam07949
760568007532	Uncharacterized conserved protein [Function unknown]; Region: COG1624
760568007533	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
760568007534	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
760568007535	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
760568007536	active site
760568007537	catalytic residues [active]
760568007538	metal binding site [ion binding]; metal-binding site
760568007539	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
760568007540	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
760568007541	tartrate dehydrogenase; Region: TTC; TIGR02089
760568007542	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
760568007543	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
760568007544	substrate binding site [chemical binding]; other site
760568007545	Dehydratase family; Region: ILVD_EDD; cl00340
760568007546	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
760568007547	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
760568007548	substrate binding site [chemical binding]; other site
760568007549	ligand binding site [chemical binding]; other site
760568007550	2-isopropylmalate synthase; Validated; Region: PRK00915
760568007551	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
760568007552	active site
760568007553	catalytic residues [active]
760568007554	metal binding site [ion binding]; metal-binding site
760568007555	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
760568007556	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
760568007557	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
760568007558	PYR/PP interface [polypeptide binding]; other site
760568007559	dimer interface [polypeptide binding]; other site
760568007560	TPP binding site [chemical binding]; other site
760568007561	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
760568007562	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
760568007563	TPP-binding site [chemical binding]; other site
760568007564	dimer interface [polypeptide binding]; other site
760568007565	ketol-acid reductoisomerase; Provisional; Region: PRK05479
760568007566	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
760568007567	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
760568007568	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
760568007569	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
760568007570	putative valine binding site [chemical binding]; other site
760568007571	dimer interface [polypeptide binding]; other site
760568007572	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
760568007573	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
760568007574	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
760568007575	PYR/PP interface [polypeptide binding]; other site
760568007576	dimer interface [polypeptide binding]; other site
760568007577	TPP binding site [chemical binding]; other site
760568007578	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
760568007579	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
760568007580	TPP-binding site [chemical binding]; other site
760568007581	dimer interface [polypeptide binding]; other site
760568007582	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
760568007583	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
760568007584	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
760568007585	homodimer interface [polypeptide binding]; other site
760568007586	substrate-cofactor binding pocket; other site
760568007587	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568007588	catalytic residue [active]
760568007589	argininosuccinate lyase; Provisional; Region: PRK00855
760568007590	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
760568007591	active sites [active]
760568007592	tetramer interface [polypeptide binding]; other site
760568007593	CHASE3 domain; Region: CHASE3; cl05000
760568007594	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568007595	PAS fold; Region: PAS_4; pfam08448
760568007596	putative active site [active]
760568007597	heme pocket [chemical binding]; other site
760568007598	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568007599	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568007600	metal binding site [ion binding]; metal-binding site
760568007601	active site
760568007602	I-site; other site
760568007603	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
760568007604	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568007605	Zn2+ binding site [ion binding]; other site
760568007606	Mg2+ binding site [ion binding]; other site
760568007607	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
760568007608	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
760568007609	dimer interface [polypeptide binding]; other site
760568007610	NAD binding site [chemical binding]; other site
760568007611	substrate binding site [chemical binding]; other site
760568007612	tetramer (dimer of dimers) interface [polypeptide binding]; other site
760568007613	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639
760568007614	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
760568007615	Walker A/P-loop; other site
760568007616	ATP binding site [chemical binding]; other site
760568007617	Q-loop/lid; other site
760568007618	ABC transporter signature motif; other site
760568007619	Walker B; other site
760568007620	D-loop; other site
760568007621	H-loop/switch region; other site
760568007622	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
760568007623	cobalt transport protein CbiN; Provisional; Region: PRK02898
760568007624	cobalt transport protein CbiM; Validated; Region: PRK08319
760568007625	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
760568007626	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
760568007627	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
760568007628	ring oligomerisation interface [polypeptide binding]; other site
760568007629	ATP/Mg binding site [chemical binding]; other site
760568007630	stacking interactions; other site
760568007631	hinge regions; other site
760568007632	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
760568007633	oligomerisation interface [polypeptide binding]; other site
760568007634	mobile loop; other site
760568007635	roof hairpin; other site
760568007636	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
760568007637	MPT binding site; other site
760568007638	trimer interface [polypeptide binding]; other site
760568007639	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
760568007640	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
760568007641	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
760568007642	GTP binding site; other site
760568007643	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
760568007644	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
760568007645	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
760568007646	FAD binding pocket [chemical binding]; other site
760568007647	FAD binding motif [chemical binding]; other site
760568007648	phosphate binding motif [ion binding]; other site
760568007649	beta-alpha-beta structure motif; other site
760568007650	NAD binding pocket [chemical binding]; other site
760568007651	Iron coordination center [ion binding]; other site
760568007652	Transposase [DNA replication, recombination, and repair]; Region: COG5421
760568007653	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
760568007654	The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759
760568007655	putative [Fe4-S4] binding site [ion binding]; other site
760568007656	putative molybdopterin cofactor binding site [chemical binding]; other site
760568007657	The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781
760568007658	putative molybdopterin cofactor binding site; other site
760568007659	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
760568007660	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
760568007661	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
760568007662	Na binding site [ion binding]; other site
760568007663	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
760568007664	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
760568007665	acyl-activating enzyme (AAE) consensus motif; other site
760568007666	AMP binding site [chemical binding]; other site
760568007667	active site
760568007668	CoA binding site [chemical binding]; other site
760568007669	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
760568007670	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
760568007671	dimer interface [polypeptide binding]; other site
760568007672	active site
760568007673	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
760568007674	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
760568007675	NADP binding site [chemical binding]; other site
760568007676	homodimer interface [polypeptide binding]; other site
760568007677	active site
760568007678	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
760568007679	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
760568007680	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
760568007681	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
760568007682	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
760568007683	substrate binding site [chemical binding]; other site
760568007684	oxyanion hole (OAH) forming residues; other site
760568007685	trimer interface [polypeptide binding]; other site
760568007686	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
760568007687	dimer interaction site [polypeptide binding]; other site
760568007688	substrate-binding tunnel; other site
760568007689	active site
760568007690	catalytic site [active]
760568007691	substrate binding site [chemical binding]; other site
760568007692	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
760568007693	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568007694	putative active site [active]
760568007695	heme pocket [chemical binding]; other site
760568007696	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568007697	Walker A motif; other site
760568007698	ATP binding site [chemical binding]; other site
760568007699	Walker B motif; other site
760568007700	arginine finger; other site
760568007701	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
760568007702	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
760568007703	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
760568007704	acyl-activating enzyme (AAE) consensus motif; other site
760568007705	putative AMP binding site [chemical binding]; other site
760568007706	putative active site [active]
760568007707	putative CoA binding site [chemical binding]; other site
760568007708	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
760568007709	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568007710	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
760568007711	Putative Fe-S cluster; Region: FeS; cl17515
760568007712	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568007713	PAS domain; Region: PAS_9; pfam13426
760568007714	putative active site [active]
760568007715	heme pocket [chemical binding]; other site
760568007716	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
760568007717	Ligand Binding Site [chemical binding]; other site
760568007718	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
760568007719	catalytic loop [active]
760568007720	iron binding site [ion binding]; other site
760568007721	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
760568007722	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
760568007723	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
760568007724	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
760568007725	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
760568007726	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
760568007727	putative dimer interface [polypeptide binding]; other site
760568007728	[2Fe-2S] cluster binding site [ion binding]; other site
760568007729	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
760568007730	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
760568007731	PBP superfamily domain; Region: PBP_like_2; pfam12849
760568007732	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
760568007733	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
760568007734	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568007735	Walker A/P-loop; other site
760568007736	ATP binding site [chemical binding]; other site
760568007737	Q-loop/lid; other site
760568007738	ABC transporter signature motif; other site
760568007739	Walker B; other site
760568007740	D-loop; other site
760568007741	H-loop/switch region; other site
760568007742	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
760568007743	active site
760568007744	metal binding site [ion binding]; metal-binding site
760568007745	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568007746	AAA domain; Region: AAA_21; pfam13304
760568007747	Walker A/P-loop; other site
760568007748	ATP binding site [chemical binding]; other site
760568007749	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
760568007750	AIR carboxylase; Region: AIRC; smart01001
760568007751	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
760568007752	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
760568007753	dimer interface [polypeptide binding]; other site
760568007754	putative functional site; other site
760568007755	putative MPT binding site; other site
760568007756	PBP superfamily domain; Region: PBP_like; pfam12727
760568007757	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
760568007758	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
760568007759	dimer interface [polypeptide binding]; other site
760568007760	putative functional site; other site
760568007761	putative MPT binding site; other site
760568007762	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
760568007763	dimer interface [polypeptide binding]; other site
760568007764	conserved gate region; other site
760568007765	putative PBP binding loops; other site
760568007766	ABC-ATPase subunit interface; other site
760568007767	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
760568007768	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
760568007769	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
760568007770	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
760568007771	ThiS family; Region: ThiS; pfam02597
760568007772	charged pocket; other site
760568007773	hydrophobic patch; other site
760568007774	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
760568007775	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
760568007776	ATP binding site [chemical binding]; other site
760568007777	substrate interface [chemical binding]; other site
760568007778	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
760568007779	MoaE interaction surface [polypeptide binding]; other site
760568007780	thiocarboxylated glycine; other site
760568007781	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
760568007782	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
760568007783	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
760568007784	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
760568007785	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
760568007786	dimer interface [polypeptide binding]; other site
760568007787	active site
760568007788	metal binding site [ion binding]; metal-binding site
760568007789	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
760568007790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568007791	active site
760568007792	phosphorylation site [posttranslational modification]
760568007793	intermolecular recognition site; other site
760568007794	dimerization interface [polypeptide binding]; other site
760568007795	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568007796	Walker A motif; other site
760568007797	ATP binding site [chemical binding]; other site
760568007798	Walker B motif; other site
760568007799	arginine finger; other site
760568007800	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
760568007801	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
760568007802	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
760568007803	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
760568007804	dimer interface [polypeptide binding]; other site
760568007805	phosphorylation site [posttranslational modification]
760568007806	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568007807	ATP binding site [chemical binding]; other site
760568007808	Mg2+ binding site [ion binding]; other site
760568007809	G-X-G motif; other site
760568007810	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
760568007811	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188
760568007812	putative active site [active]
760568007813	metal binding site [ion binding]; metal-binding site
760568007814	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
760568007815	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
760568007816	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
760568007817	Transposase domain (DUF772); Region: DUF772; pfam05598
760568007818	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
760568007819	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
760568007820	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
760568007821	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568007822	Walker A motif; other site
760568007823	ATP binding site [chemical binding]; other site
760568007824	Walker B motif; other site
760568007825	arginine finger; other site
760568007826	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
760568007827	Integrase core domain; Region: rve; pfam00665
760568007828	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
760568007829	Winged helix-turn helix; Region: HTH_29; pfam13551
760568007830	Homeodomain-like domain; Region: HTH_32; pfam13565
760568007831	Integrase core domain; Region: rve; pfam00665
760568007832	Integrase core domain; Region: rve_3; cl15866
760568007833	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
760568007834	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568007835	Walker A motif; other site
760568007836	ATP binding site [chemical binding]; other site
760568007837	Walker B motif; other site
760568007838	arginine finger; other site
760568007839	Archaeal protein of unknown function (DUF911); Region: DUF911; pfam06023
760568007840	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A; cl17680
760568007841	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
760568007842	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
760568007843	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
760568007844	The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910
760568007845	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
760568007846	CRISPR-associated negative auto-regulator DevR/Csa2; Region: DevR; pfam01905
760568007847	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
760568007848	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
760568007849	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
760568007850	Predicted transcriptional regulator [Transcription]; Region: COG2378
760568007851	WYL domain; Region: WYL; pfam13280
760568007852	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
760568007853	Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040
760568007854	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
760568007855	putative active site [active]
760568007856	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
760568007857	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
760568007858	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
760568007859	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
760568007860	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
760568007861	inhibitor-cofactor binding pocket; inhibition site
760568007862	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568007863	catalytic residue [active]
760568007864	amino acid transporter; Region: 2A0306; TIGR00909
760568007865	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
760568007866	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
760568007867	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
760568007868	NAD(P) binding site [chemical binding]; other site
760568007869	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
760568007870	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568007871	putative active site [active]
760568007872	heme pocket [chemical binding]; other site
760568007873	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568007874	Walker A motif; other site
760568007875	ATP binding site [chemical binding]; other site
760568007876	Walker B motif; other site
760568007877	arginine finger; other site
760568007878	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
760568007879	molybdopterin cofactor binding site; other site
760568007880	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
760568007881	molybdopterin cofactor binding site; other site
760568007882	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
760568007883	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
760568007884	catalytic loop [active]
760568007885	iron binding site [ion binding]; other site
760568007886	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
760568007887	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568007888	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
760568007889	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
760568007890	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
760568007891	catalytic loop [active]
760568007892	iron binding site [ion binding]; other site
760568007893	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
760568007894	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
760568007895	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
760568007896	dimer interface [polypeptide binding]; other site
760568007897	[2Fe-2S] cluster binding site [ion binding]; other site
760568007898	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
760568007899	SLBB domain; Region: SLBB; pfam10531
760568007900	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
760568007901	4Fe-4S binding domain; Region: Fer4; pfam00037
760568007902	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568007903	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
760568007904	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
760568007905	putative dimer interface [polypeptide binding]; other site
760568007906	[2Fe-2S] cluster binding site [ion binding]; other site
760568007907	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
760568007908	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
760568007909	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
760568007910	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568007911	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
760568007912	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
760568007913	Putative Fe-S cluster; Region: FeS; cl17515
760568007914	PAS fold; Region: PAS_4; pfam08448
760568007915	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568007916	putative active site [active]
760568007917	heme pocket [chemical binding]; other site
760568007918	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
760568007919	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
760568007920	catalytic loop [active]
760568007921	iron binding site [ion binding]; other site
760568007922	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
760568007923	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568007924	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
760568007925	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
760568007926	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
760568007927	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
760568007928	dimer interface [polypeptide binding]; other site
760568007929	[2Fe-2S] cluster binding site [ion binding]; other site
760568007930	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
760568007931	dimer interface [polypeptide binding]; other site
760568007932	[2Fe-2S] cluster binding site [ion binding]; other site
760568007933	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
760568007934	SLBB domain; Region: SLBB; pfam10531
760568007935	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
760568007936	4Fe-4S binding domain; Region: Fer4; pfam00037
760568007937	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568007938	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
760568007939	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
760568007940	putative dimer interface [polypeptide binding]; other site
760568007941	[2Fe-2S] cluster binding site [ion binding]; other site
760568007942	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
760568007943	ACT domain-containing protein [General function prediction only]; Region: COG4747
760568007944	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
760568007945	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
760568007946	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
760568007947	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
760568007948	acyl-activating enzyme (AAE) consensus motif; other site
760568007949	AMP binding site [chemical binding]; other site
760568007950	active site
760568007951	CoA binding site [chemical binding]; other site
760568007952	UGMP family protein; Validated; Region: PRK09604
760568007953	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
760568007954	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
760568007955	putative catalytic site [active]
760568007956	putative metal binding site [ion binding]; other site
760568007957	putative phosphate binding site [ion binding]; other site
760568007958	NAD-dependent deacetylase; Provisional; Region: PRK00481
760568007959	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
760568007960	NAD+ binding site [chemical binding]; other site
760568007961	substrate binding site [chemical binding]; other site
760568007962	Zn binding site [ion binding]; other site
760568007963	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
760568007964	Double zinc ribbon; Region: DZR; pfam12773
760568007965	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
760568007966	Coenzyme A binding pocket [chemical binding]; other site
760568007967	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
760568007968	Integrase core domain; Region: rve; pfam00665
760568007969	transposase; Provisional; Region: PRK06526
760568007970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568007971	Walker A motif; other site
760568007972	ATP binding site [chemical binding]; other site
760568007973	Walker B motif; other site
760568007974	arginine finger; other site
760568007975	FAD binding domain; Region: FAD_binding_4; pfam01565
760568007976	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
760568007977	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568007978	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
760568007979	Cysteine-rich domain; Region: CCG; pfam02754
760568007980	Cysteine-rich domain; Region: CCG; pfam02754
760568007981	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
760568007982	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
760568007983	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
760568007984	catalytic residues [active]
760568007985	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
760568007986	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
760568007987	S-layer homology domain; Region: SLH; pfam00395
760568007988	S-layer homology domain; Region: SLH; pfam00395
760568007989	Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214
760568007990	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
760568007991	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
760568007992	23S rRNA interface [nucleotide binding]; other site
760568007993	L3 interface [polypeptide binding]; other site
760568007994	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
760568007995	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
760568007996	dimerization interface 3.5A [polypeptide binding]; other site
760568007997	active site
760568007998	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
760568007999	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
760568008000	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
760568008001	Walker A/P-loop; other site
760568008002	ATP binding site [chemical binding]; other site
760568008003	Q-loop/lid; other site
760568008004	ABC transporter signature motif; other site
760568008005	Walker B; other site
760568008006	D-loop; other site
760568008007	H-loop/switch region; other site
760568008008	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
760568008009	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
760568008010	Walker A/P-loop; other site
760568008011	ATP binding site [chemical binding]; other site
760568008012	Q-loop/lid; other site
760568008013	ABC transporter signature motif; other site
760568008014	Walker B; other site
760568008015	D-loop; other site
760568008016	H-loop/switch region; other site
760568008017	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
760568008018	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
760568008019	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
760568008020	alphaNTD homodimer interface [polypeptide binding]; other site
760568008021	alphaNTD - beta interaction site [polypeptide binding]; other site
760568008022	alphaNTD - beta' interaction site [polypeptide binding]; other site
760568008023	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
760568008024	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
760568008025	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
760568008026	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
760568008027	RNA binding surface [nucleotide binding]; other site
760568008028	30S ribosomal protein S11; Validated; Region: PRK05309
760568008029	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
760568008030	30S ribosomal protein S13; Region: bact_S13; TIGR03631
760568008031	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
760568008032	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
760568008033	rRNA binding site [nucleotide binding]; other site
760568008034	predicted 30S ribosome binding site; other site
760568008035	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
760568008036	RNA binding site [nucleotide binding]; other site
760568008037	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
760568008038	active site
760568008039	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
760568008040	SecY translocase; Region: SecY; pfam00344
760568008041	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
760568008042	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
760568008043	23S rRNA binding site [nucleotide binding]; other site
760568008044	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
760568008045	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
760568008046	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
760568008047	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
760568008048	5S rRNA interface [nucleotide binding]; other site
760568008049	L27 interface [polypeptide binding]; other site
760568008050	23S rRNA interface [nucleotide binding]; other site
760568008051	L5 interface [polypeptide binding]; other site
760568008052	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
760568008053	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
760568008054	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
760568008055	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
760568008056	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
760568008057	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
760568008058	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
760568008059	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
760568008060	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
760568008061	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
760568008062	RNA binding site [nucleotide binding]; other site
760568008063	FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764
760568008064	Zn binding sites [ion binding]; other site
760568008065	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
760568008066	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
760568008067	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
760568008068	23S rRNA interface [nucleotide binding]; other site
760568008069	putative translocon interaction site; other site
760568008070	signal recognition particle (SRP54) interaction site; other site
760568008071	L23 interface [polypeptide binding]; other site
760568008072	trigger factor interaction site; other site
760568008073	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
760568008074	23S rRNA interface [nucleotide binding]; other site
760568008075	5S rRNA interface [nucleotide binding]; other site
760568008076	putative antibiotic binding site [chemical binding]; other site
760568008077	L25 interface [polypeptide binding]; other site
760568008078	L27 interface [polypeptide binding]; other site
760568008079	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
760568008080	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
760568008081	G-X-X-G motif; other site
760568008082	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
760568008083	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
760568008084	putative translocon binding site; other site
760568008085	protein-rRNA interface [nucleotide binding]; other site
760568008086	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
760568008087	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
760568008088	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
760568008089	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
760568008090	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
760568008091	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
760568008092	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
760568008093	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
760568008094	elongation factor Tu; Reviewed; Region: PRK00049
760568008095	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
760568008096	G1 box; other site
760568008097	GEF interaction site [polypeptide binding]; other site
760568008098	GTP/Mg2+ binding site [chemical binding]; other site
760568008099	Switch I region; other site
760568008100	G2 box; other site
760568008101	G3 box; other site
760568008102	Switch II region; other site
760568008103	G4 box; other site
760568008104	G5 box; other site
760568008105	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
760568008106	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
760568008107	Antibiotic Binding Site [chemical binding]; other site
760568008108	elongation factor G; Reviewed; Region: PRK00007
760568008109	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
760568008110	G1 box; other site
760568008111	putative GEF interaction site [polypeptide binding]; other site
760568008112	GTP/Mg2+ binding site [chemical binding]; other site
760568008113	Switch I region; other site
760568008114	G2 box; other site
760568008115	G3 box; other site
760568008116	Switch II region; other site
760568008117	G4 box; other site
760568008118	G5 box; other site
760568008119	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
760568008120	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
760568008121	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
760568008122	30S ribosomal protein S7; Validated; Region: PRK05302
760568008123	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
760568008124	S17 interaction site [polypeptide binding]; other site
760568008125	S8 interaction site; other site
760568008126	16S rRNA interaction site [nucleotide binding]; other site
760568008127	streptomycin interaction site [chemical binding]; other site
760568008128	23S rRNA interaction site [nucleotide binding]; other site
760568008129	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
760568008130	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602
760568008131	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
760568008132	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
760568008133	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
760568008134	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
760568008135	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
760568008136	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
760568008137	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
760568008138	G-loop; other site
760568008139	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
760568008140	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
760568008141	DNA binding site [nucleotide binding]
760568008142	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
760568008143	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
760568008144	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
760568008145	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
760568008146	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
760568008147	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
760568008148	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
760568008149	RPB1 interaction site [polypeptide binding]; other site
760568008150	RPB10 interaction site [polypeptide binding]; other site
760568008151	RPB11 interaction site [polypeptide binding]; other site
760568008152	RPB3 interaction site [polypeptide binding]; other site
760568008153	RPB12 interaction site [polypeptide binding]; other site
760568008154	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
760568008155	peripheral dimer interface [polypeptide binding]; other site
760568008156	core dimer interface [polypeptide binding]; other site
760568008157	L10 interface [polypeptide binding]; other site
760568008158	L11 interface [polypeptide binding]; other site
760568008159	putative EF-Tu interaction site [polypeptide binding]; other site
760568008160	putative EF-G interaction site [polypeptide binding]; other site
760568008161	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
760568008162	23S rRNA interface [nucleotide binding]; other site
760568008163	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
760568008164	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
760568008165	mRNA/rRNA interface [nucleotide binding]; other site
760568008166	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
760568008167	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
760568008168	23S rRNA interface [nucleotide binding]; other site
760568008169	L7/L12 interface [polypeptide binding]; other site
760568008170	putative thiostrepton binding site; other site
760568008171	L25 interface [polypeptide binding]; other site
760568008172	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
760568008173	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
760568008174	putative homodimer interface [polypeptide binding]; other site
760568008175	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
760568008176	heterodimer interface [polypeptide binding]; other site
760568008177	homodimer interface [polypeptide binding]; other site
760568008178	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
760568008179	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
760568008180	elongation factor Tu; Reviewed; Region: PRK00049
760568008181	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
760568008182	G1 box; other site
760568008183	GEF interaction site [polypeptide binding]; other site
760568008184	GTP/Mg2+ binding site [chemical binding]; other site
760568008185	Switch I region; other site
760568008186	G2 box; other site
760568008187	G3 box; other site
760568008188	Switch II region; other site
760568008189	G4 box; other site
760568008190	G5 box; other site
760568008191	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
760568008192	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
760568008193	Antibiotic Binding Site [chemical binding]; other site
760568008194	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
760568008195	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
760568008196	NodB motif; other site
760568008197	active site
760568008198	catalytic site [active]
760568008199	Cd binding site [ion binding]; other site
760568008200	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568008201	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
760568008202	active site residue [active]
760568008203	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
760568008204	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
760568008205	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
760568008206	putative ligand binding site [chemical binding]; other site
760568008207	putative NAD binding site [chemical binding]; other site
760568008208	catalytic site [active]
760568008209	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
760568008210	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
760568008211	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
760568008212	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
760568008213	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
760568008214	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
760568008215	putative active site [active]
760568008216	metal binding site [ion binding]; metal-binding site
760568008217	PAS domain; Region: PAS_9; pfam13426
760568008218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568008219	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
760568008220	Walker A motif; other site
760568008221	ATP binding site [chemical binding]; other site
760568008222	Walker B motif; other site
760568008223	arginine finger; other site
760568008224	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
760568008225	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568008226	Major Facilitator Superfamily; Region: MFS_1; pfam07690
760568008227	putative substrate translocation pore; other site
760568008228	phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344
760568008229	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
760568008230	active site
760568008231	metal-binding site [ion binding]
760568008232	nucleotide-binding site [chemical binding]; other site
760568008233	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
760568008234	Protein of unknown function (DUF763); Region: DUF763; pfam05559
760568008235	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
760568008236	Ligand Binding Site [chemical binding]; other site
760568008237	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
760568008238	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
760568008239	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568008240	putative substrate translocation pore; other site
760568008241	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
760568008242	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
760568008243	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
760568008244	Rubredoxin [Energy production and conversion]; Region: COG1773
760568008245	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
760568008246	iron binding site [ion binding]; other site
760568008247	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
760568008248	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
760568008249	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
760568008250	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
760568008251	Protein of unknown function (DUF2600); Region: DUF2600; pfam10776
760568008252	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
760568008253	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
760568008254	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
760568008255	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
760568008256	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
760568008257	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
760568008258	Cysteine-rich domain; Region: CCG; pfam02754
760568008259	Cysteine-rich domain; Region: CCG; pfam02754
760568008260	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
760568008261	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263
760568008262	L-aspartate oxidase; Provisional; Region: PRK06175
760568008263	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
760568008264	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
760568008265	Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838
760568008266	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568008267	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
760568008268	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
760568008269	2-methylcitrate dehydratase; Region: prpD; TIGR02330
760568008270	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
760568008271	CoA binding domain; Region: CoA_binding; pfam02629
760568008272	CoA-ligase; Region: Ligase_CoA; pfam00549
760568008273	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
760568008274	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
760568008275	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
760568008276	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
760568008277	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
760568008278	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
760568008279	active site
760568008280	oxalacetate binding site [chemical binding]; other site
760568008281	citrylCoA binding site [chemical binding]; other site
760568008282	coenzyme A binding site [chemical binding]; other site
760568008283	catalytic triad [active]
760568008284	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
760568008285	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
760568008286	tetramer interface [polypeptide binding]; other site
760568008287	active site
760568008288	Mg2+/Mn2+ binding site [ion binding]; other site
760568008289	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
760568008290	DctM-like transporters; Region: DctM; pfam06808
760568008291	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
760568008292	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
760568008293	membrane-bound complex binding site; other site
760568008294	Transcriptional regulators [Transcription]; Region: FadR; COG2186
760568008295	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
760568008296	DNA-binding site [nucleotide binding]; DNA binding site
760568008297	FCD domain; Region: FCD; pfam07729
760568008298	GAF domain; Region: GAF; cl17456
760568008299	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568008300	PAS domain; Region: PAS_9; pfam13426
760568008301	putative active site [active]
760568008302	heme pocket [chemical binding]; other site
760568008303	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
760568008304	Cysteine-rich domain; Region: CCG; pfam02754
760568008305	Cysteine-rich domain; Region: CCG; pfam02754
760568008306	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
760568008307	aconitate hydratase; Validated; Region: PRK07229
760568008308	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
760568008309	substrate binding site [chemical binding]; other site
760568008310	ligand binding site [chemical binding]; other site
760568008311	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
760568008312	substrate binding site [chemical binding]; other site
760568008313	FAD binding domain; Region: FAD_binding_2; pfam00890
760568008314	L-aspartate oxidase; Provisional; Region: PRK06175
760568008315	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568008316	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
760568008317	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
760568008318	isocitrate dehydrogenase; Validated; Region: PRK06451
760568008319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
760568008320	DctM-like transporters; Region: DctM; pfam06808
760568008321	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
760568008322	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
760568008323	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
760568008324	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
760568008325	Domain of unknown function (DUF3870); Region: DUF3870; pfam12986
760568008326	drug efflux system protein MdtG; Provisional; Region: PRK09874
760568008327	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568008328	putative substrate translocation pore; other site
760568008329	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
760568008330	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
760568008331	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
760568008332	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
760568008333	TPP-binding site [chemical binding]; other site
760568008334	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
760568008335	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
760568008336	dimer interface [polypeptide binding]; other site
760568008337	PYR/PP interface [polypeptide binding]; other site
760568008338	TPP binding site [chemical binding]; other site
760568008339	substrate binding site [chemical binding]; other site
760568008340	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568008341	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568008342	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
760568008343	catalytic loop [active]
760568008344	iron binding site [ion binding]; other site
760568008345	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
760568008346	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568008347	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
760568008348	dimer interface [polypeptide binding]; other site
760568008349	[2Fe-2S] cluster binding site [ion binding]; other site
760568008350	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
760568008351	SLBB domain; Region: SLBB; pfam10531
760568008352	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
760568008353	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
760568008354	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
760568008355	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
760568008356	putative dimer interface [polypeptide binding]; other site
760568008357	[2Fe-2S] cluster binding site [ion binding]; other site
760568008358	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
760568008359	homodimer interface [polypeptide binding]; other site
760568008360	chemical substrate binding site [chemical binding]; other site
760568008361	oligomer interface [polypeptide binding]; other site
760568008362	metal binding site [ion binding]; metal-binding site
760568008363	RNA polymerase factor sigma-70; Validated; Region: PRK08295
760568008364	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
760568008365	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
760568008366	YacP-like NYN domain; Region: NYN_YacP; pfam05991
760568008367	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
760568008368	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
760568008369	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
760568008370	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
760568008371	active site
760568008372	metal binding site [ion binding]; metal-binding site
760568008373	dimerization interface [polypeptide binding]; other site
760568008374	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
760568008375	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
760568008376	active site
760568008377	HIGH motif; other site
760568008378	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
760568008379	KMSKS motif; other site
760568008380	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
760568008381	tRNA binding surface [nucleotide binding]; other site
760568008382	anticodon binding site; other site
760568008383	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
760568008384	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
760568008385	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
760568008386	trimer interface [polypeptide binding]; other site
760568008387	active site
760568008388	substrate binding site [chemical binding]; other site
760568008389	CoA binding site [chemical binding]; other site
760568008390	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
760568008391	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
760568008392	HIGH motif; other site
760568008393	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
760568008394	active site
760568008395	KMSKS motif; other site
760568008396	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
760568008397	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
760568008398	CoA-binding site [chemical binding]; other site
760568008399	ATP-binding [chemical binding]; other site
760568008400	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
760568008401	homotrimer interaction site [polypeptide binding]; other site
760568008402	zinc binding site [ion binding]; other site
760568008403	CDP-binding sites; other site
760568008404	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
760568008405	substrate binding site; other site
760568008406	dimer interface; other site
760568008407	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
760568008408	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
760568008409	putative active site [active]
760568008410	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
760568008411	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
760568008412	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
760568008413	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
760568008414	Cysteine-rich domain; Region: CCG; pfam02754
760568008415	Cysteine-rich domain; Region: CCG; pfam02754
760568008416	FAD binding domain; Region: FAD_binding_4; pfam01565
760568008417	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
760568008418	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
760568008419	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
760568008420	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
760568008421	Helix-hairpin-helix motif; Region: HHH; pfam00633
760568008422	DNA repair protein RadA; Provisional; Region: PRK11823
760568008423	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
760568008424	Walker A motif/ATP binding site; other site
760568008425	ATP binding site [chemical binding]; other site
760568008426	Walker B motif; other site
760568008427	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
760568008428	Probable transposase; Region: OrfB_IS605; pfam01385
760568008429	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
760568008430	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
760568008431	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
760568008432	putative active site [active]
760568008433	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
760568008434	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
760568008435	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
760568008436	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
760568008437	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
760568008438	Transposase, Mutator family; Region: Transposase_mut; pfam00872
760568008439	Transposase [DNA replication, recombination, and repair]; Region: COG5421
760568008440	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
760568008441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568008442	active site
760568008443	phosphorylation site [posttranslational modification]
760568008444	intermolecular recognition site; other site
760568008445	dimerization interface [polypeptide binding]; other site
760568008446	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
760568008447	DNA binding site [nucleotide binding]
760568008448	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568008449	peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078
760568008450	FeS/SAM binding site; other site
760568008451	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
760568008452	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
760568008453	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568008454	Walker A/P-loop; other site
760568008455	ATP binding site [chemical binding]; other site
760568008456	Q-loop/lid; other site
760568008457	ABC transporter signature motif; other site
760568008458	Walker B; other site
760568008459	D-loop; other site
760568008460	H-loop/switch region; other site
760568008461	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
760568008462	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
760568008463	HlyD family secretion protein; Region: HlyD_3; pfam13437
760568008464	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
760568008465	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
760568008466	Walker A/P-loop; other site
760568008467	ATP binding site [chemical binding]; other site
760568008468	Q-loop/lid; other site
760568008469	ABC transporter signature motif; other site
760568008470	Walker B; other site
760568008471	D-loop; other site
760568008472	H-loop/switch region; other site
760568008473	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
760568008474	FtsX-like permease family; Region: FtsX; pfam02687
760568008475	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
760568008476	phosphate binding site [ion binding]; other site
760568008477	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568008478	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
760568008479	Walker A motif; other site
760568008480	ATP binding site [chemical binding]; other site
760568008481	Walker B motif; other site
760568008482	arginine finger; other site
760568008483	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
760568008484	active site
760568008485	catalytic triad [active]
760568008486	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
760568008487	Integrase core domain; Region: rve; pfam00665
760568008488	transposase; Provisional; Region: PRK06526
760568008489	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568008490	Walker A motif; other site
760568008491	ATP binding site [chemical binding]; other site
760568008492	Walker B motif; other site
760568008493	arginine finger; other site
760568008494	Clp protease ATP binding subunit; Region: clpC; CHL00095
760568008495	Clp amino terminal domain; Region: Clp_N; pfam02861
760568008496	Clp amino terminal domain; Region: Clp_N; pfam02861
760568008497	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568008498	Walker A motif; other site
760568008499	ATP binding site [chemical binding]; other site
760568008500	Walker B motif; other site
760568008501	arginine finger; other site
760568008502	UvrB/uvrC motif; Region: UVR; pfam02151
760568008503	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568008504	Walker A motif; other site
760568008505	ATP binding site [chemical binding]; other site
760568008506	Walker B motif; other site
760568008507	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
760568008508	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
760568008509	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
760568008510	ADP binding site [chemical binding]; other site
760568008511	phosphagen binding site; other site
760568008512	substrate specificity loop; other site
760568008513	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
760568008514	UvrB/uvrC motif; Region: UVR; pfam02151
760568008515	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
760568008516	Ubiquitin-like proteins; Region: UBQ; cl00155
760568008517	charged pocket; other site
760568008518	hydrophobic patch; other site
760568008519	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
760568008520	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
760568008521	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
760568008522	NAD(P) binding site [chemical binding]; other site
760568008523	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568008524	Domain of unknown function (DUF202); Region: DUF202; cl09954
760568008525	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
760568008526	TatD related DNase; Region: TatD_DNase; pfam01026
760568008527	active site
760568008528	Uncharacterized conserved protein [Function unknown]; Region: COG1416
760568008529	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
760568008530	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
760568008531	dimer interface [polypeptide binding]; other site
760568008532	putative anticodon binding site; other site
760568008533	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
760568008534	motif 1; other site
760568008535	active site
760568008536	motif 2; other site
760568008537	motif 3; other site
760568008538	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
760568008539	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
760568008540	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
760568008541	Predicted dehydrogenase [General function prediction only]; Region: COG5322
760568008542	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
760568008543	NAD(P) binding pocket [chemical binding]; other site
760568008544	non-specific DNA binding site [nucleotide binding]; other site
760568008545	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
760568008546	salt bridge; other site
760568008547	sequence-specific DNA binding site [nucleotide binding]; other site
760568008548	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
760568008549	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
760568008550	FMN binding site [chemical binding]; other site
760568008551	active site
760568008552	catalytic residues [active]
760568008553	substrate binding site [chemical binding]; other site
760568008554	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
760568008555	nucleotide binding site [chemical binding]; other site
760568008556	Type III pantothenate kinase; Region: Pan_kinase; cl17198
760568008557	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
760568008558	dimerization interface [polypeptide binding]; other site
760568008559	putative DNA binding site [nucleotide binding]; other site
760568008560	putative Zn2+ binding site [ion binding]; other site
760568008561	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
760568008562	Biotin operon repressor [Transcription]; Region: BirA; COG1654
760568008563	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
760568008564	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
760568008565	BioY family; Region: BioY; pfam02632
760568008566	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
760568008567	Protein of unknown function (DUF499); Region: DUF499; pfam04465
760568008568	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
760568008569	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
760568008570	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
760568008571	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
760568008572	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
760568008573	non-specific DNA binding site [nucleotide binding]; other site
760568008574	salt bridge; other site
760568008575	sequence-specific DNA binding site [nucleotide binding]; other site
760568008576	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
760568008577	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
760568008578	ATP binding site [chemical binding]; other site
760568008579	putative Mg++ binding site [ion binding]; other site
760568008580	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
760568008581	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
760568008582	nucleotide binding region [chemical binding]; other site
760568008583	ATP-binding site [chemical binding]; other site
760568008584	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
760568008585	CHASE4 domain; Region: CHASE4; pfam05228
760568008586	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
760568008587	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568008588	putative active site [active]
760568008589	heme pocket [chemical binding]; other site
760568008590	PAS fold; Region: PAS_4; pfam08448
760568008591	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568008592	putative active site [active]
760568008593	heme pocket [chemical binding]; other site
760568008594	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568008595	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568008596	metal binding site [ion binding]; metal-binding site
760568008597	active site
760568008598	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
760568008599	I-site; other site
760568008600	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568008601	Zn2+ binding site [ion binding]; other site
760568008602	Mg2+ binding site [ion binding]; other site
760568008603	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
760568008604	putative active site [active]
760568008605	Protein of unknown function, DUF488; Region: DUF488; pfam04343
760568008606	Protein of unknown function, DUF488; Region: DUF488; pfam04343
760568008607	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
760568008608	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
760568008609	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
760568008610	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568008611	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568008612	metal binding site [ion binding]; metal-binding site
760568008613	active site
760568008614	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
760568008615	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
760568008616	putative active site [active]
760568008617	putative metal binding site [ion binding]; other site
760568008618	Predicted integral membrane protein [Function unknown]; Region: COG5658
760568008619	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
760568008620	SdpI/YhfL protein family; Region: SdpI; pfam13630
760568008621	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
760568008622	dimerization interface [polypeptide binding]; other site
760568008623	putative DNA binding site [nucleotide binding]; other site
760568008624	putative Zn2+ binding site [ion binding]; other site
760568008625	Transcriptional regulators [Transcription]; Region: FadR; COG2186
760568008626	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
760568008627	DNA-binding site [nucleotide binding]; DNA binding site
760568008628	FCD domain; Region: FCD; pfam07729
760568008629	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
760568008630	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
760568008631	dimerization interface [polypeptide binding]; other site
760568008632	active site
760568008633	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
760568008634	L-aspartate oxidase; Provisional; Region: PRK06175
760568008635	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
760568008636	Quinolinate synthetase A protein; Region: NadA; pfam02445
760568008637	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
760568008638	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
760568008639	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
760568008640	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263
760568008641	L-aspartate oxidase; Provisional; Region: PRK06175
760568008642	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
760568008643	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
760568008644	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
760568008645	transmembrane helices; other site
760568008646	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
760568008647	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
760568008648	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
760568008649	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
760568008650	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
760568008651	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
760568008652	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568008653	Walker A motif; other site
760568008654	ATP binding site [chemical binding]; other site
760568008655	Walker B motif; other site
760568008656	arginine finger; other site
760568008657	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
760568008658	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
760568008659	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
760568008660	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
760568008661	DNA binding residues [nucleotide binding]
760568008662	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
760568008663	catalytic residues [active]
760568008664	catalytic nucleophile [active]
760568008665	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
760568008666	DNA binding residues [nucleotide binding]
760568008667	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
760568008668	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
760568008669	catalytic residues [active]
760568008670	catalytic nucleophile [active]
760568008671	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
760568008672	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
760568008673	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
760568008674	G4 box; other site
760568008675	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263
760568008676	L-aspartate oxidase; Provisional; Region: PRK06175
760568008677	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
760568008678	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
760568008679	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
760568008680	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
760568008681	Iron-sulfur protein interface; other site
760568008682	proximal heme binding site [chemical binding]; other site
760568008683	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
760568008684	Iron-sulfur protein interface; other site
760568008685	proximal heme binding site [chemical binding]; other site
760568008686	Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838
760568008687	fumarate hydratase; Provisional; Region: PRK06246
760568008688	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
760568008689	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
760568008690	transmembrane helices; other site
760568008691	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
760568008692	DctM-like transporters; Region: DctM; pfam06808
760568008693	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
760568008694	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
760568008695	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802
760568008696	Cache domain; Region: Cache_1; pfam02743
760568008697	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
760568008698	dimerization interface [polypeptide binding]; other site
760568008699	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
760568008700	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
760568008701	dimer interface [polypeptide binding]; other site
760568008702	putative CheW interface [polypeptide binding]; other site
760568008703	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
760568008704	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
760568008705	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
760568008706	Transcriptional regulators [Transcription]; Region: FadR; COG2186
760568008707	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
760568008708	DNA-binding site [nucleotide binding]; DNA binding site
760568008709	FCD domain; Region: FCD; pfam07729
760568008710	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
760568008711	tetramerization interface [polypeptide binding]; other site
760568008712	active site
760568008713	pantoate--beta-alanine ligase; Region: panC; TIGR00018
760568008714	Pantoate-beta-alanine ligase; Region: PanC; cd00560
760568008715	active site
760568008716	ATP-binding site [chemical binding]; other site
760568008717	pantoate-binding site; other site
760568008718	HXXH motif; other site
760568008719	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
760568008720	active site
760568008721	oligomerization interface [polypeptide binding]; other site
760568008722	metal binding site [ion binding]; metal-binding site
760568008723	Uncharacterized conserved protein [Function unknown]; Region: COG5495
760568008724	Rossmann-like domain; Region: Rossmann-like; pfam10727
760568008725	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
760568008726	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
760568008727	Methyltransferase domain; Region: Methyltransf_31; pfam13847
760568008728	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568008729	S-adenosylmethionine binding site [chemical binding]; other site
760568008730	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
760568008731	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
760568008732	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
760568008733	Soluble P-type ATPase [General function prediction only]; Region: COG4087
760568008734	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568008735	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568008736	metal binding site [ion binding]; metal-binding site
760568008737	active site
760568008738	I-site; other site
760568008739	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
760568008740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568008741	Major Facilitator Superfamily; Region: MFS_1; pfam07690
760568008742	putative substrate translocation pore; other site
760568008743	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
760568008744	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
760568008745	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
760568008746	active site
760568008747	CGGC domain; Region: CGGC; cl02356
760568008748	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
760568008749	SmpB-tmRNA interface; other site
760568008750	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
760568008751	Zn2+ binding site [ion binding]; other site
760568008752	Mg2+ binding site [ion binding]; other site
760568008753	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
760568008754	CoenzymeA binding site [chemical binding]; other site
760568008755	subunit interaction site [polypeptide binding]; other site
760568008756	PHB binding site; other site
760568008757	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568008758	Radical SAM superfamily; Region: Radical_SAM; pfam04055
760568008759	FeS/SAM binding site; other site
760568008760	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
760568008761	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
760568008762	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
760568008763	putative homodimer interface [polypeptide binding]; other site
760568008764	putative homotetramer interface [polypeptide binding]; other site
760568008765	putative allosteric switch controlling residues; other site
760568008766	putative metal binding site [ion binding]; other site
760568008767	putative homodimer-homodimer interface [polypeptide binding]; other site
760568008768	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
760568008769	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
760568008770	enolase; Provisional; Region: eno; PRK00077
760568008771	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
760568008772	dimer interface [polypeptide binding]; other site
760568008773	metal binding site [ion binding]; metal-binding site
760568008774	substrate binding pocket [chemical binding]; other site
760568008775	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
760568008776	phosphoglyceromutase; Provisional; Region: PRK05434
760568008777	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
760568008778	triosephosphate isomerase; Provisional; Region: PRK14567
760568008779	substrate binding site [chemical binding]; other site
760568008780	dimer interface [polypeptide binding]; other site
760568008781	catalytic triad [active]
760568008782	Phosphoglycerate kinase; Region: PGK; pfam00162
760568008783	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
760568008784	substrate binding site [chemical binding]; other site
760568008785	hinge regions; other site
760568008786	ADP binding site [chemical binding]; other site
760568008787	catalytic site [active]
760568008788	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
760568008789	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
760568008790	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
760568008791	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
760568008792	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
760568008793	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
760568008794	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
760568008795	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
760568008796	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
760568008797	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
760568008798	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
760568008799	putative active site [active]
760568008800	putative metal binding site [ion binding]; other site
760568008801	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
760568008802	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
760568008803	putative substrate binding pocket [chemical binding]; other site
760568008804	dimer interface [polypeptide binding]; other site
760568008805	phosphate binding site [ion binding]; other site
760568008806	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
760568008807	AAA domain; Region: AAA_33; pfam13671
760568008808	bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674
760568008809	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017
760568008810	dimer interface [polypeptide binding]; other site
760568008811	active site
760568008812	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
760568008813	dimer interface [polypeptide binding]; other site
760568008814	active site
760568008815	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
760568008816	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
760568008817	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
760568008818	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
760568008819	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
760568008820	nucleotide binding site [chemical binding]; other site
760568008821	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
760568008822	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
760568008823	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
760568008824	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
760568008825	GIY-YIG motif/motif A; other site
760568008826	active site
760568008827	catalytic site [active]
760568008828	putative DNA binding site [nucleotide binding]; other site
760568008829	metal binding site [ion binding]; metal-binding site
760568008830	UvrB/uvrC motif; Region: UVR; pfam02151
760568008831	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
760568008832	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
760568008833	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
760568008834	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
760568008835	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
760568008836	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
760568008837	putative active site [active]
760568008838	excinuclease ABC subunit B; Provisional; Region: PRK05298
760568008839	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
760568008840	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
760568008841	ATP-binding site [chemical binding]; other site
760568008842	ATP binding site [chemical binding]; other site
760568008843	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
760568008844	nucleotide binding region [chemical binding]; other site
760568008845	ATP-binding site [chemical binding]; other site
760568008846	Ultra-violet resistance protein B; Region: UvrB; pfam12344
760568008847	UvrB/uvrC motif; Region: UVR; pfam02151
760568008848	Flagellin N-methylase; Region: FliB; pfam03692
760568008849	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
760568008850	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
760568008851	Fe-S cluster binding site [ion binding]; other site
760568008852	active site
760568008853	Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133
760568008854	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
760568008855	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
760568008856	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
760568008857	C-terminal peptidase (prc); Region: prc; TIGR00225
760568008858	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
760568008859	protein binding site [polypeptide binding]; other site
760568008860	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
760568008861	Catalytic dyad [active]
760568008862	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
760568008863	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
760568008864	Peptidase family M23; Region: Peptidase_M23; pfam01551
760568008865	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
760568008866	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
760568008867	FtsX-like permease family; Region: FtsX; pfam02687
760568008868	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
760568008869	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568008870	Walker A/P-loop; other site
760568008871	ATP binding site [chemical binding]; other site
760568008872	Q-loop/lid; other site
760568008873	ABC transporter signature motif; other site
760568008874	Walker B; other site
760568008875	D-loop; other site
760568008876	H-loop/switch region; other site
760568008877	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
760568008878	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
760568008879	PYR/PP interface [polypeptide binding]; other site
760568008880	dimer interface [polypeptide binding]; other site
760568008881	TPP binding site [chemical binding]; other site
760568008882	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
760568008883	transketolase; Reviewed; Region: PRK05899
760568008884	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
760568008885	TPP-binding site [chemical binding]; other site
760568008886	dimer interface [polypeptide binding]; other site
760568008887	Uncharacterized conserved protein [Function unknown]; Region: COG1284
760568008888	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
760568008889	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
760568008890	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
760568008891	FOG: CBS domain [General function prediction only]; Region: COG0517
760568008892	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
760568008893	PAS domain; Region: PAS_9; pfam13426
760568008894	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568008895	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568008896	metal binding site [ion binding]; metal-binding site
760568008897	active site
760568008898	I-site; other site
760568008899	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
760568008900	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568008901	Zn2+ binding site [ion binding]; other site
760568008902	Mg2+ binding site [ion binding]; other site
760568008903	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
760568008904	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
760568008905	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
760568008906	FtsX-like permease family; Region: FtsX; pfam02687
760568008907	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
760568008908	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
760568008909	Walker A/P-loop; other site
760568008910	ATP binding site [chemical binding]; other site
760568008911	Q-loop/lid; other site
760568008912	ABC transporter signature motif; other site
760568008913	Walker B; other site
760568008914	D-loop; other site
760568008915	H-loop/switch region; other site
760568008916	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
760568008917	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
760568008918	HlyD family secretion protein; Region: HlyD_3; pfam13437
760568008919	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
760568008920	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
760568008921	dimerization interface [polypeptide binding]; other site
760568008922	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
760568008923	dimer interface [polypeptide binding]; other site
760568008924	phosphorylation site [posttranslational modification]
760568008925	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
760568008926	ATP binding site [chemical binding]; other site
760568008927	Mg2+ binding site [ion binding]; other site
760568008928	G-X-G motif; other site
760568008929	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
760568008930	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568008931	active site
760568008932	phosphorylation site [posttranslational modification]
760568008933	intermolecular recognition site; other site
760568008934	dimerization interface [polypeptide binding]; other site
760568008935	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
760568008936	DNA binding site [nucleotide binding]
760568008937	peptide chain release factor 2; Validated; Region: prfB; PRK00578
760568008938	PCRF domain; Region: PCRF; pfam03462
760568008939	RF-1 domain; Region: RF-1; pfam00472
760568008940	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
760568008941	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
760568008942	ATP binding site [chemical binding]; other site
760568008943	putative Mg++ binding site [ion binding]; other site
760568008944	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
760568008945	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
760568008946	30S subunit binding site; other site
760568008947	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
760568008948	DNA-binding site [nucleotide binding]; DNA binding site
760568008949	RNA-binding motif; other site
760568008950	NAD synthetase; Provisional; Region: PRK13981
760568008951	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
760568008952	multimer interface [polypeptide binding]; other site
760568008953	active site
760568008954	catalytic triad [active]
760568008955	protein interface 1 [polypeptide binding]; other site
760568008956	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
760568008957	homodimer interface [polypeptide binding]; other site
760568008958	NAD binding pocket [chemical binding]; other site
760568008959	ATP binding pocket [chemical binding]; other site
760568008960	Mg binding site [ion binding]; other site
760568008961	active-site loop [active]
760568008962	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
760568008963	active site
760568008964	catalytic residues [active]
760568008965	metal binding site [ion binding]; metal-binding site
760568008966	Radical SAM superfamily; Region: Radical_SAM; pfam04055
760568008967	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568008968	FeS/SAM binding site; other site
760568008969	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
760568008970	Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967
760568008971	Nitrogenase_MoFe_beta_like: Nitrogenase MoFe protein, beta subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen (N2) to ammonia.  This group contains the beta subunits of component 1 of the three known genetically...; Region: Nitrogenase_MoFe_beta_like; cd01965
760568008972	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
760568008973	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
760568008974	Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967
760568008975	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
760568008976	Nitrogen regulatory protein P-II; Region: P-II; smart00938
760568008977	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
760568008978	Nitrogen regulatory protein P-II; Region: P-II; smart00938
760568008979	nitrogenase iron protein; Region: nifH; TIGR01287
760568008980	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
760568008981	Nucleotide-binding sites [chemical binding]; other site
760568008982	Switch I region of nucleotide binding site; other site
760568008983	Fe4S4 binding sites [ion binding]; other site
760568008984	Switch II region of nucleotide binding site; other site
760568008985	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
760568008986	Nitrogen regulatory protein P-II; Region: P-II; smart00938
760568008987	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
760568008988	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
760568008989	Cysteine-rich domain; Region: CCG; pfam02754
760568008990	Cysteine-rich domain; Region: CCG; pfam02754
760568008991	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
760568008992	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
760568008993	glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377
760568008994	hydroxyglutarate oxidase; Provisional; Region: PRK11728
760568008995	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
760568008996	glycerol kinase; Provisional; Region: glpK; PRK00047
760568008997	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
760568008998	N- and C-terminal domain interface [polypeptide binding]; other site
760568008999	active site
760568009000	MgATP binding site [chemical binding]; other site
760568009001	catalytic site [active]
760568009002	metal binding site [ion binding]; metal-binding site
760568009003	glycerol binding site [chemical binding]; other site
760568009004	homotetramer interface [polypeptide binding]; other site
760568009005	homodimer interface [polypeptide binding]; other site
760568009006	FBP binding site [chemical binding]; other site
760568009007	protein IIAGlc interface [polypeptide binding]; other site
760568009008	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
760568009009	amphipathic channel; other site
760568009010	Asn-Pro-Ala signature motifs; other site
760568009011	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
760568009012	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
760568009013	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
760568009014	active site
760568009015	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
760568009016	GAF domain; Region: GAF; pfam01590
760568009017	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568009018	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568009019	metal binding site [ion binding]; metal-binding site
760568009020	active site
760568009021	I-site; other site
760568009022	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
760568009023	S-adenosylmethionine synthetase; Validated; Region: PRK05250
760568009024	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
760568009025	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
760568009026	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
760568009027	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
760568009028	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
760568009029	YvrJ protein family; Region: YvrJ; pfam12841
760568009030	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
760568009031	putative active site [active]
760568009032	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
760568009033	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
760568009034	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
760568009035	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
760568009036	active site
760568009037	substrate binding site [chemical binding]; other site
760568009038	metal binding site [ion binding]; metal-binding site
760568009039	Predicted membrane protein [Function unknown]; Region: COG2323
760568009040	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
760568009041	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
760568009042	NAD binding site [chemical binding]; other site
760568009043	substrate binding site [chemical binding]; other site
760568009044	homodimer interface [polypeptide binding]; other site
760568009045	active site
760568009046	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
760568009047	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
760568009048	active site
760568009049	tetramer interface; other site
760568009050	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
760568009051	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
760568009052	Mg++ binding site [ion binding]; other site
760568009053	putative catalytic motif [active]
760568009054	substrate binding site [chemical binding]; other site
760568009055	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
760568009056	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
760568009057	PQQ-like domain; Region: PQQ_2; pfam13360
760568009058	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
760568009059	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
760568009060	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568009061	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
760568009062	Transcriptional regulator [Transcription]; Region: LytR; COG1316
760568009063	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
760568009064	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
760568009065	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
760568009066	oligomeric interface; other site
760568009067	putative active site [active]
760568009068	homodimer interface [polypeptide binding]; other site
760568009069	Post-segregation antitoxin CcdA; Region: CcdA; cl02188
760568009070	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
760568009071	Major Facilitator Superfamily; Region: MFS_1; pfam07690
760568009072	putative substrate translocation pore; other site
760568009073	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
760568009074	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
760568009075	HlyD family secretion protein; Region: HlyD_3; pfam13437
760568009076	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
760568009077	Protein export membrane protein; Region: SecD_SecF; cl14618
760568009078	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
760568009079	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
760568009080	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
760568009081	HlyD family secretion protein; Region: HlyD_3; pfam13437
760568009082	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
760568009083	MarR family; Region: MarR_2; pfam12802
760568009084	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
760568009085	putative active site [active]
760568009086	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
760568009087	Uncharacterized conserved protein [Function unknown]; Region: COG3465
760568009088	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
760568009089	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568009090	Zn2+ binding site [ion binding]; other site
760568009091	Mg2+ binding site [ion binding]; other site
760568009092	Outer membrane efflux protein; Region: OEP; pfam02321
760568009093	Outer membrane efflux protein; Region: OEP; pfam02321
760568009094	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
760568009095	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
760568009096	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
760568009097	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
760568009098	HlyD family secretion protein; Region: HlyD_3; pfam13437
760568009099	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
760568009100	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
760568009101	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
760568009102	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
760568009103	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
760568009104	Transposase IS200 like; Region: Y1_Tnp; pfam01797
760568009105	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
760568009106	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
760568009107	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
760568009108	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
760568009109	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
760568009110	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
760568009111	active site
760568009112	NTP binding site [chemical binding]; other site
760568009113	metal binding triad [ion binding]; metal-binding site
760568009114	antibiotic binding site [chemical binding]; other site
760568009115	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
760568009116	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
760568009117	putative active site [active]
760568009118	catalytic triad [active]
760568009119	S-layer homology domain; Region: SLH; pfam00395
760568009120	S-layer homology domain; Region: SLH; pfam00395
760568009121	S-layer homology domain; Region: SLH; pfam00395
760568009122	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
760568009123	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
760568009124	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
760568009125	oligomeric interface; other site
760568009126	putative active site [active]
760568009127	homodimer interface [polypeptide binding]; other site
760568009128	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
760568009129	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
760568009130	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
760568009131	DNA binding residues [nucleotide binding]
760568009132	Putative zinc-finger; Region: zf-HC2; pfam13490
760568009133	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
760568009134	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
760568009135	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
760568009136	putative active site [active]
760568009137	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
760568009138	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
760568009139	active site
760568009140	catalytic triad [active]
760568009141	S-layer homology domain; Region: SLH; pfam00395
760568009142	S-layer homology domain; Region: SLH; pfam00395
760568009143	S-layer homology domain; Region: SLH; pfam00395
760568009144	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
760568009145	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
760568009146	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
760568009147	putative active site [active]
760568009148	rod shape-determining protein Mbl; Provisional; Region: PRK13928
760568009149	MreB and similar proteins; Region: MreB_like; cd10225
760568009150	nucleotide binding site [chemical binding]; other site
760568009151	Mg binding site [ion binding]; other site
760568009152	putative protofilament interaction site [polypeptide binding]; other site
760568009153	RodZ interaction site [polypeptide binding]; other site
760568009154	Stage III sporulation protein D; Region: SpoIIID; pfam12116
760568009155	Peptidase family M23; Region: Peptidase_M23; pfam01551
760568009156	Stage II sporulation protein; Region: SpoIID; pfam08486
760568009157	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
760568009158	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
760568009159	gamma subunit interface [polypeptide binding]; other site
760568009160	LBP interface [polypeptide binding]; other site
760568009161	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
760568009162	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
760568009163	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
760568009164	alpha subunit interaction interface [polypeptide binding]; other site
760568009165	Walker A motif; other site
760568009166	ATP binding site [chemical binding]; other site
760568009167	Walker B motif; other site
760568009168	inhibitor binding site; inhibition site
760568009169	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
760568009170	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
760568009171	core domain interface [polypeptide binding]; other site
760568009172	delta subunit interface [polypeptide binding]; other site
760568009173	epsilon subunit interface [polypeptide binding]; other site
760568009174	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
760568009175	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
760568009176	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
760568009177	beta subunit interaction interface [polypeptide binding]; other site
760568009178	Walker A motif; other site
760568009179	ATP binding site [chemical binding]; other site
760568009180	Walker B motif; other site
760568009181	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
760568009182	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
760568009183	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
760568009184	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
760568009185	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
760568009186	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
760568009187	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
760568009188	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
760568009189	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
760568009190	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
760568009191	active site
760568009192	homodimer interface [polypeptide binding]; other site
760568009193	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
760568009194	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
760568009195	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
760568009196	DNA binding residues [nucleotide binding]
760568009197	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
760568009198	catalytic residues [active]
760568009199	catalytic nucleophile [active]
760568009200	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
760568009201	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
760568009202	motif II; other site
760568009203	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
760568009204	catalytic motif [active]
760568009205	Zn binding site [ion binding]; other site
760568009206	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
760568009207	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
760568009208	dimer interface [polypeptide binding]; other site
760568009209	active site
760568009210	glycine-pyridoxal phosphate binding site [chemical binding]; other site
760568009211	folate binding site [chemical binding]; other site
760568009212	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
760568009213	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
760568009214	Low molecular weight phosphatase family; Region: LMWPc; cd00115
760568009215	active site
760568009216	Domain of unknown function DUF; Region: DUF204; pfam02659
760568009217	Domain of unknown function DUF; Region: DUF204; pfam02659
760568009218	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
760568009219	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
760568009220	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
760568009221	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
760568009222	Walker A/P-loop; other site
760568009223	ATP binding site [chemical binding]; other site
760568009224	Q-loop/lid; other site
760568009225	ABC transporter signature motif; other site
760568009226	Walker B; other site
760568009227	D-loop; other site
760568009228	H-loop/switch region; other site
760568009229	ABC-2 type transporter; Region: ABC2_membrane; cl17235
760568009230	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
760568009231	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
760568009232	ABC-ATPase subunit  interface; other site
760568009233	dimer interface [polypeptide binding]; other site
760568009234	putative PBP binding regions; other site
760568009235	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
760568009236	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
760568009237	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
760568009238	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
760568009239	metal binding site [ion binding]; metal-binding site
760568009240	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
760568009241	metal binding site 2 [ion binding]; metal-binding site
760568009242	putative DNA binding helix; other site
760568009243	metal binding site 1 [ion binding]; metal-binding site
760568009244	dimer interface [polypeptide binding]; other site
760568009245	structural Zn2+ binding site [ion binding]; other site
760568009246	High-affinity nickel-transport protein; Region: NicO; cl00964
760568009247	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
760568009248	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568009249	S-adenosylmethionine binding site [chemical binding]; other site
760568009250	peptide chain release factor 1; Validated; Region: prfA; PRK00591
760568009251	This domain is found in peptide chain release factors; Region: PCRF; smart00937
760568009252	RF-1 domain; Region: RF-1; pfam00472
760568009253	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
760568009254	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
760568009255	Response regulator receiver domain; Region: Response_reg; pfam00072
760568009256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568009257	active site
760568009258	phosphorylation site [posttranslational modification]
760568009259	intermolecular recognition site; other site
760568009260	dimerization interface [polypeptide binding]; other site
760568009261	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568009262	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568009263	metal binding site [ion binding]; metal-binding site
760568009264	active site
760568009265	I-site; other site
760568009266	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568009267	Radical SAM superfamily; Region: Radical_SAM; pfam04055
760568009268	FeS/SAM binding site; other site
760568009269	Fic family protein [Function unknown]; Region: COG3177
760568009270	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
760568009271	Fic/DOC family; Region: Fic; pfam02661
760568009272	HTH DNA binding domain; Region: HTH_13; pfam11972
760568009273	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
760568009274	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
760568009275	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
760568009276	Peptidase family M23; Region: Peptidase_M23; pfam01551
760568009277	transcription termination factor Rho; Provisional; Region: rho; PRK09376
760568009278	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
760568009279	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
760568009280	RNA binding site [nucleotide binding]; other site
760568009281	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
760568009282	multimer interface [polypeptide binding]; other site
760568009283	Walker A motif; other site
760568009284	ATP binding site [chemical binding]; other site
760568009285	Walker B motif; other site
760568009286	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
760568009287	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
760568009288	active site
760568009289	intersubunit interactions; other site
760568009290	catalytic residue [active]
760568009291	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
760568009292	intersubunit interface [polypeptide binding]; other site
760568009293	active site
760568009294	zinc binding site [ion binding]; other site
760568009295	Na+ binding site [ion binding]; other site
760568009296	Response regulator receiver domain; Region: Response_reg; pfam00072
760568009297	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
760568009298	active site
760568009299	phosphorylation site [posttranslational modification]
760568009300	intermolecular recognition site; other site
760568009301	dimerization interface [polypeptide binding]; other site
760568009302	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
760568009303	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
760568009304	tandem repeat interface [polypeptide binding]; other site
760568009305	oligomer interface [polypeptide binding]; other site
760568009306	active site residues [active]
760568009307	CTP synthetase; Validated; Region: pyrG; PRK05380
760568009308	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
760568009309	Catalytic site [active]
760568009310	active site
760568009311	UTP binding site [chemical binding]; other site
760568009312	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
760568009313	active site
760568009314	putative oxyanion hole; other site
760568009315	catalytic triad [active]
760568009316	XapX domain; Region: XapX; TIGR03510
760568009317	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
760568009318	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
760568009319	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
760568009320	active site
760568009321	HIGH motif; other site
760568009322	KMSK motif region; other site
760568009323	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
760568009324	tRNA binding surface [nucleotide binding]; other site
760568009325	anticodon binding site; other site
760568009326	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
760568009327	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
760568009328	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
760568009329	Transposase [DNA replication, recombination, and repair]; Region: COG5421
760568009330	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
760568009331	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
760568009332	transmembrane helices; other site
760568009333	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
760568009334	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
760568009335	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
760568009336	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
760568009337	dimer interface [polypeptide binding]; other site
760568009338	PYR/PP interface [polypeptide binding]; other site
760568009339	TPP binding site [chemical binding]; other site
760568009340	substrate binding site [chemical binding]; other site
760568009341	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
760568009342	TPP-binding site; other site
760568009343	4Fe-4S binding domain; Region: Fer4; pfam00037
760568009344	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
760568009345	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
760568009346	acyl-activating enzyme (AAE) consensus motif; other site
760568009347	AMP binding site [chemical binding]; other site
760568009348	active site
760568009349	CoA binding site [chemical binding]; other site
760568009350	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
760568009351	Na binding site [ion binding]; other site
760568009352	hypothetical protein; Validated; Region: PRK07682
760568009353	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
760568009354	pyridoxal 5'-phosphate binding site [chemical binding]; other site
760568009355	homodimer interface [polypeptide binding]; other site
760568009356	catalytic residue [active]
760568009357	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
760568009358	AsnC family; Region: AsnC_trans_reg; pfam01037
760568009359	germination protein YpeB; Region: spore_YpeB; TIGR02889
760568009360	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
760568009361	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
760568009362	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
760568009363	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
760568009364	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
760568009365	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
760568009366	catalytic triad [active]
760568009367	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
760568009368	DsrC like protein; Region: DsrC; pfam04358
760568009369	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
760568009370	Cysteine-rich domain; Region: CCG; pfam02754
760568009371	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
760568009372	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
760568009373	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
760568009374	TPR repeat; Region: TPR_11; pfam13414
760568009375	binding surface
760568009376	TPR motif; other site
760568009377	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
760568009378	binding surface
760568009379	TPR repeat; Region: TPR_11; pfam13414
760568009380	TPR motif; other site
760568009381	TPR repeat; Region: TPR_11; pfam13414
760568009382	Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679
760568009383	sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066
760568009384	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
760568009385	sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064
760568009386	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
760568009387	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
760568009388	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
760568009389	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
760568009390	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
760568009391	hinge; other site
760568009392	active site
760568009393	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
760568009394	TPR repeat; Region: TPR_11; pfam13414
760568009395	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
760568009396	TPR motif; other site
760568009397	binding surface
760568009398	TPR repeat; Region: TPR_11; pfam13414
760568009399	Homeodomain-like domain; Region: HTH_23; cl17451
760568009400	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
760568009401	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
760568009402	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
760568009403	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
760568009404	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
760568009405	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
760568009406	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
760568009407	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
760568009408	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
760568009409	G5 domain; Region: G5; pfam07501
760568009410	Peptidase family M23; Region: Peptidase_M23; pfam01551
760568009411	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
760568009412	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
760568009413	FeS/SAM binding site; other site
760568009414	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
760568009415	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
760568009416	FOG: CBS domain [General function prediction only]; Region: COG0517
760568009417	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
760568009418	Transposase [DNA replication, recombination, and repair]; Region: COG5421
760568009419	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
760568009420	CHASE3 domain; Region: CHASE3; pfam05227
760568009421	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
760568009422	PAS fold; Region: PAS_4; pfam08448
760568009423	putative active site [active]
760568009424	heme pocket [chemical binding]; other site
760568009425	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
760568009426	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
760568009427	metal binding site [ion binding]; metal-binding site
760568009428	active site
760568009429	I-site; other site
760568009430	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
760568009431	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
760568009432	Zn2+ binding site [ion binding]; other site
760568009433	Mg2+ binding site [ion binding]; other site
760568009434	Helix-turn-helix domain; Region: HTH_17; pfam12728
760568009435	Helix-turn-helix domain; Region: HTH_17; pfam12728
760568009436	CHC2 zinc finger; Region: zf-CHC2; cl17510
760568009437	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
760568009438	active site
760568009439	metal binding site [ion binding]; metal-binding site
760568009440	interdomain interaction site; other site
760568009441	Domain of unknown function (DUF927); Region: DUF927; cl12098
760568009442	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
760568009443	DNA binding residues [nucleotide binding]
760568009444	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
760568009445	integrase; Provisional; Region: int; PHA02601
760568009446	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
760568009447	Int/Topo IB signature motif; other site
760568009448	Methyltransferase domain; Region: Methyltransf_23; pfam13489
760568009449	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
760568009450	S-adenosylmethionine binding site [chemical binding]; other site
760568009451	Sulfatase; Region: Sulfatase; pfam00884
760568009452	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
760568009453	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
760568009454	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
760568009455	Active Sites [active]
760568009456	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
760568009457	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
760568009458	NADP-binding site; other site
760568009459	homotetramer interface [polypeptide binding]; other site
760568009460	substrate binding site [chemical binding]; other site
760568009461	homodimer interface [polypeptide binding]; other site
760568009462	active site
760568009463	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
760568009464	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
760568009465	Probable Catalytic site; other site
760568009466	metal-binding site
760568009467	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
760568009468	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
760568009469	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
760568009470	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
760568009471	active site
760568009472	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
760568009473	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
760568009474	active site
760568009475	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
760568009476	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
760568009477	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
760568009478	Probable Catalytic site; other site
760568009479	metal-binding site
760568009480	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
760568009481	putative metal binding site; other site
760568009482	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
760568009483	binding surface
760568009484	TPR motif; other site
760568009485	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
760568009486	binding surface
760568009487	TPR motif; other site
760568009488	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
760568009489	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
760568009490	putative metal binding site; other site
760568009491	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
760568009492	binding surface
760568009493	TPR motif; other site
760568009494	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
760568009495	binding surface
760568009496	TPR motif; other site
760568009497	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
760568009498	putative metal binding site; other site
760568009499	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
760568009500	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
760568009501	active site
760568009502	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
760568009503	active site
760568009504	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
760568009505	dimer interface [polypeptide binding]; other site
760568009506	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
760568009507	Ligand Binding Site [chemical binding]; other site
760568009508	Molecular Tunnel; other site
760568009509	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
760568009510	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
760568009511	GDP-binding site [chemical binding]; other site
760568009512	ACT binding site; other site
760568009513	IMP binding site; other site
760568009514	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
760568009515	L-aspartate oxidase; Provisional; Region: PRK06175
760568009516	replicative DNA helicase; Validated; Region: PRK07773
760568009517	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
760568009518	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
760568009519	Walker A motif; other site
760568009520	ATP binding site [chemical binding]; other site
760568009521	Walker B motif; other site
760568009522	DNA binding loops [nucleotide binding]
760568009523	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
760568009524	protein-splicing catalytic site; other site
760568009525	thioester formation/cholesterol transfer; other site
760568009526	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
760568009527	protein-splicing catalytic site; other site
760568009528	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
760568009529	ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903
760568009530	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
760568009531	Walker A motif; other site
760568009532	ATP binding site [chemical binding]; other site
760568009533	Walker B motif; other site
760568009534	arginine finger; other site
760568009535	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
760568009536	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
760568009537	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
760568009538	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
760568009539	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
760568009540	MazG-like family; Region: MazG-like; pfam12643
760568009541	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
760568009542	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
760568009543	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
760568009544	dimer interface [polypeptide binding]; other site
760568009545	ssDNA binding site [nucleotide binding]; other site
760568009546	tetramer (dimer of dimers) interface [polypeptide binding]; other site
760568009547	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
760568009548	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
760568009549	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
760568009550	Mechanosensitive ion channel; Region: MS_channel; pfam00924
760568009551	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
760568009552	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
760568009553	oligomer interface [polypeptide binding]; other site
760568009554	putative active site [active]
760568009555	metal binding site [ion binding]; metal-binding site
760568009556	Colicin V production protein; Region: Colicin_V; pfam02674
760568009557	Uncharacterized membrane protein [Function unknown]; Region: COG3949
760568009558	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
760568009559	Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214
760568009560	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
760568009561	active site
760568009562	ParB-like nuclease domain; Region: ParBc; pfam02195
760568009563	KorB domain; Region: KorB; pfam08535
760568009564	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
760568009565	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
760568009566	P-loop; other site
760568009567	Magnesium ion binding site [ion binding]; other site
760568009568	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
760568009569	Magnesium ion binding site [ion binding]; other site
760568009570	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
760568009571	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
760568009572	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
760568009573	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
760568009574	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
760568009575	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
760568009576	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
760568009577	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
760568009578	trmE is a tRNA modification GTPase; Region: trmE; cd04164
760568009579	G1 box; other site
760568009580	GTP/Mg2+ binding site [chemical binding]; other site
760568009581	Switch I region; other site
760568009582	G2 box; other site
760568009583	Switch II region; other site
760568009584	G3 box; other site
760568009585	G4 box; other site
760568009586	G5 box; other site
760568009587	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
760568009588	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
760568009589	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
760568009590	G-X-X-G motif; other site
760568009591	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
760568009592	RxxxH motif; other site
760568009593	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
760568009594	Haemolytic domain; Region: Haemolytic; pfam01809
760568009595	ribonuclease P; Reviewed; Region: rnpA; PRK00499
760568009596	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399