-- dump date   	20140619_064045
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
690850000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
690850000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
690850000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850000004	Walker A motif; other site
690850000005	ATP binding site [chemical binding]; other site
690850000006	Walker B motif; other site
690850000007	arginine finger; other site
690850000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
690850000009	DnaA box-binding interface [nucleotide binding]; other site
690850000010	hypothetical protein; Provisional; Region: PRK04334
690850000011	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
690850000012	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
690850000013	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850000014	Walker A motif; other site
690850000015	ATP binding site [chemical binding]; other site
690850000016	Walker B motif; other site
690850000017	arginine finger; other site
690850000018	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
690850000019	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14602
690850000020	RuvA N terminal domain; Region: RuvA_N; pfam01330
690850000021	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
690850000022	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
690850000023	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
690850000024	active site
690850000025	putative DNA-binding cleft [nucleotide binding]; other site
690850000026	dimer interface [polypeptide binding]; other site
690850000027	hypothetical protein; Validated; Region: PRK00110
690850000028	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
690850000029	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850000030	S-adenosylmethionine binding site [chemical binding]; other site
690850000031	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
690850000032	Cupin domain; Region: Cupin_2; pfam07883
690850000033	Major Facilitator Superfamily; Region: MFS_1; pfam07690
690850000034	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
690850000035	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
690850000036	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
690850000037	molybdopterin cofactor binding site; other site
690850000038	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
690850000039	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
690850000040	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850000041	Zn2+ binding site [ion binding]; other site
690850000042	Mg2+ binding site [ion binding]; other site
690850000043	Response regulator receiver domain; Region: Response_reg; pfam00072
690850000044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850000045	active site
690850000046	phosphorylation site [posttranslational modification]
690850000047	intermolecular recognition site; other site
690850000048	dimerization interface [polypeptide binding]; other site
690850000049	Tim44-like domain; Region: Tim44; pfam04280
690850000050	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850000051	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
690850000052	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850000053	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
690850000054	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
690850000055	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
690850000056	Substrate binding site; other site
690850000057	metal-binding site
690850000058	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
690850000059	putative active site [active]
690850000060	putative metal binding site [ion binding]; other site
690850000061	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
690850000062	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
690850000063	putative metal binding site; other site
690850000064	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850000065	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850000066	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850000067	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
690850000068	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
690850000069	active site
690850000070	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
690850000071	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
690850000072	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850000073	catalytic residue [active]
690850000074	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
690850000075	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
690850000076	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
690850000077	FAD binding site [chemical binding]; other site
690850000078	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
690850000079	active site
690850000080	8-oxo-dGMP binding site [chemical binding]; other site
690850000081	nudix motif; other site
690850000082	metal binding site [ion binding]; metal-binding site
690850000083	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
690850000084	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
690850000085	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
690850000086	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
690850000087	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
690850000088	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
690850000089	Methyltransferase domain; Region: Methyltransf_31; pfam13847
690850000090	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850000091	S-adenosylmethionine binding site [chemical binding]; other site
690850000092	Protein of unknown function (DUF3419); Region: DUF3419; pfam11899
690850000093	FOG: CBS domain [General function prediction only]; Region: COG0517
690850000094	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
690850000095	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
690850000096	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
690850000097	active site
690850000098	(T/H)XGH motif; other site
690850000099	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
690850000100	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
690850000101	putative catalytic cysteine [active]
690850000102	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
690850000103	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
690850000104	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
690850000105	dimer interface [polypeptide binding]; other site
690850000106	PYR/PP interface [polypeptide binding]; other site
690850000107	TPP binding site [chemical binding]; other site
690850000108	substrate binding site [chemical binding]; other site
690850000109	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
690850000110	TPP-binding site; other site
690850000111	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
690850000112	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
690850000113	GAF domain; Region: GAF; pfam01590
690850000114	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850000115	Walker A motif; other site
690850000116	ATP binding site [chemical binding]; other site
690850000117	Walker B motif; other site
690850000118	arginine finger; other site
690850000119	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850000120	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
690850000121	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
690850000122	active site
690850000123	HIGH motif; other site
690850000124	nucleotide binding site [chemical binding]; other site
690850000125	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
690850000126	KMSKS motif; other site
690850000127	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
690850000128	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
690850000129	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
690850000130	3D domain; Region: 3D; cl01439
690850000131	3D domain; Region: 3D; cl01439
690850000132	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
690850000133	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
690850000134	homodimer interface [polypeptide binding]; other site
690850000135	substrate-cofactor binding pocket; other site
690850000136	catalytic residue [active]
690850000137	Methyltransferase domain; Region: Methyltransf_31; pfam13847
690850000138	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850000139	S-adenosylmethionine binding site [chemical binding]; other site
690850000140	DsrE/DsrF-like family; Region: DrsE; pfam02635
690850000141	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
690850000142	EamA-like transporter family; Region: EamA; pfam00892
690850000143	EamA-like transporter family; Region: EamA; pfam00892
690850000144	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
690850000145	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
690850000146	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
690850000147	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
690850000148	Cupin domain; Region: Cupin_2; cl17218
690850000149	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
690850000150	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
690850000151	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
690850000152	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
690850000153	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850000154	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850000155	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
690850000156	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850000157	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
690850000158	Sodium Bile acid symporter family; Region: SBF; cl17470
690850000159	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
690850000160	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
690850000161	Competence protein; Region: Competence; pfam03772
690850000162	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
690850000163	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
690850000164	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
690850000165	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
690850000166	ligand binding site [chemical binding]; other site
690850000167	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
690850000168	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
690850000169	hinge; other site
690850000170	active site
690850000171	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850000172	Tetratricopeptide repeat; Region: TPR_16; pfam13432
690850000173	TPR motif; other site
690850000174	binding surface
690850000175	ATP synthase subunit C; Region: ATP-synt_C; cl00466
690850000176	Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276
690850000177	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
690850000178	G1 box; other site
690850000179	putative GEF interaction site [polypeptide binding]; other site
690850000180	GTP/Mg2+ binding site [chemical binding]; other site
690850000181	Switch I region; other site
690850000182	G2 box; other site
690850000183	G3 box; other site
690850000184	Switch II region; other site
690850000185	G4 box; other site
690850000186	G5 box; other site
690850000187	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
690850000188	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
690850000189	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
690850000190	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
690850000191	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
690850000192	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
690850000193	oligomer interface [polypeptide binding]; other site
690850000194	putative active site [active]
690850000195	metal binding site [ion binding]; metal-binding site
690850000196	selenocysteine synthase; Provisional; Region: PRK04311
690850000197	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
690850000198	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
690850000199	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
690850000200	catalytic residue [active]
690850000201	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
690850000202	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
690850000203	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850000204	dimerization interface [polypeptide binding]; other site
690850000205	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
690850000206	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
690850000207	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
690850000208	NAD binding site [chemical binding]; other site
690850000209	homodimer interface [polypeptide binding]; other site
690850000210	active site
690850000211	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
690850000212	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
690850000213	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
690850000214	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
690850000215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850000216	dimer interface [polypeptide binding]; other site
690850000217	ABC-ATPase subunit interface; other site
690850000218	putative PBP binding loops; other site
690850000219	hypothetical protein; Provisional; Region: PRK11622
690850000220	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
690850000221	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
690850000222	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
690850000223	Walker A/P-loop; other site
690850000224	ATP binding site [chemical binding]; other site
690850000225	Q-loop/lid; other site
690850000226	ABC transporter signature motif; other site
690850000227	Walker B; other site
690850000228	D-loop; other site
690850000229	H-loop/switch region; other site
690850000230	TOBE domain; Region: TOBE_2; pfam08402
690850000231	Phosphotransferase enzyme family; Region: APH; pfam01636
690850000232	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
690850000233	active site
690850000234	substrate binding site [chemical binding]; other site
690850000235	ATP binding site [chemical binding]; other site
690850000236	Uncharacterized conserved protein [Function unknown]; Region: COG0398
690850000237	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
690850000238	mercuric reductase; Validated; Region: PRK06370
690850000239	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
690850000240	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
690850000241	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
690850000242	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
690850000243	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
690850000244	Protein of unknown function, DUF547; Region: DUF547; pfam04784
690850000245	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
690850000246	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
690850000247	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
690850000248	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
690850000249	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
690850000250	transketolase; Reviewed; Region: PRK05899
690850000251	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
690850000252	TPP-binding site [chemical binding]; other site
690850000253	dimer interface [polypeptide binding]; other site
690850000254	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
690850000255	PYR/PP interface [polypeptide binding]; other site
690850000256	dimer interface [polypeptide binding]; other site
690850000257	TPP binding site [chemical binding]; other site
690850000258	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
690850000259	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
690850000260	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
690850000261	putative active site [active]
690850000262	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
690850000263	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
690850000264	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
690850000265	Probable Catalytic site; other site
690850000266	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
690850000267	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850000268	putative active site [active]
690850000269	heme pocket [chemical binding]; other site
690850000270	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850000271	phosphorylation site [posttranslational modification]
690850000272	dimer interface [polypeptide binding]; other site
690850000273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850000274	ATP binding site [chemical binding]; other site
690850000275	Mg2+ binding site [ion binding]; other site
690850000276	G-X-G motif; other site
690850000277	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
690850000278	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
690850000279	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
690850000280	ABC transporter; Region: ABC_tran_2; pfam12848
690850000281	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
690850000282	Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314
690850000283	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850000284	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
690850000285	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
690850000286	ligand binding site [chemical binding]; other site
690850000287	flexible hinge region; other site
690850000288	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
690850000289	non-specific DNA interactions [nucleotide binding]; other site
690850000290	DNA binding site [nucleotide binding]
690850000291	sequence specific DNA binding site [nucleotide binding]; other site
690850000292	putative cAMP binding site [chemical binding]; other site
690850000293	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
690850000294	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
690850000295	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
690850000296	L-aspartate oxidase; Provisional; Region: PRK06175
690850000297	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
690850000298	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
690850000299	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
690850000300	transmembrane helices; other site
690850000301	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850000302	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850000303	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850000304	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
690850000305	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
690850000306	ring oligomerisation interface [polypeptide binding]; other site
690850000307	ATP/Mg binding site [chemical binding]; other site
690850000308	stacking interactions; other site
690850000309	hinge regions; other site
690850000310	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
690850000311	oligomerisation interface [polypeptide binding]; other site
690850000312	mobile loop; other site
690850000313	roof hairpin; other site
690850000314	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
690850000315	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
690850000316	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
690850000317	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
690850000318	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
690850000319	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850000320	homodimer interface [polypeptide binding]; other site
690850000321	catalytic residue [active]
690850000322	cobyric acid synthase; Provisional; Region: PRK00784
690850000323	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
690850000324	catalytic triad [active]
690850000325	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
690850000326	KpsF/GutQ family protein; Region: kpsF; TIGR00393
690850000327	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
690850000328	putative active site [active]
690850000329	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
690850000330	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
690850000331	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
690850000332	active site
690850000333	tetramer interface [polypeptide binding]; other site
690850000334	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
690850000335	active site
690850000336	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
690850000337	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
690850000338	ATP-grasp domain; Region: ATP-grasp_4; cl17255
690850000339	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
690850000340	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
690850000341	ATP-grasp domain; Region: ATP-grasp_4; cl17255
690850000342	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
690850000343	IMP binding site; other site
690850000344	dimer interface [polypeptide binding]; other site
690850000345	interdomain contacts; other site
690850000346	partial ornithine binding site; other site
690850000347	Arginase family; Region: Arginase; cd09989
690850000348	agmatinase; Region: agmatinase; TIGR01230
690850000349	active site
690850000350	Mn binding site [ion binding]; other site
690850000351	oligomer interface [polypeptide binding]; other site
690850000352	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
690850000353	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
690850000354	putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311
690850000355	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850000356	FeS/SAM binding site; other site
690850000357	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
690850000358	acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165
690850000359	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
690850000360	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
690850000361	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
690850000362	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
690850000363	FHIPEP family; Region: FHIPEP; pfam00771
690850000364	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
690850000365	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722
690850000366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850000367	Walker A motif; other site
690850000368	ATP binding site [chemical binding]; other site
690850000369	Walker B motif; other site
690850000370	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
690850000371	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
690850000372	P-loop; other site
690850000373	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
690850000374	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
690850000375	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
690850000376	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
690850000377	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
690850000378	DNA binding residues [nucleotide binding]
690850000379	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
690850000380	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850000381	active site
690850000382	phosphorylation site [posttranslational modification]
690850000383	intermolecular recognition site; other site
690850000384	dimerization interface [polypeptide binding]; other site
690850000385	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
690850000386	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
690850000387	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
690850000388	FMN binding site [chemical binding]; other site
690850000389	active site
690850000390	catalytic residues [active]
690850000391	substrate binding site [chemical binding]; other site
690850000392	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
690850000393	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850000394	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850000395	active site
690850000396	phosphorylation site [posttranslational modification]
690850000397	intermolecular recognition site; other site
690850000398	dimerization interface [polypeptide binding]; other site
690850000399	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
690850000400	dimerization interface [polypeptide binding]; other site
690850000401	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
690850000402	ATP binding site [chemical binding]; other site
690850000403	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
690850000404	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
690850000405	HupF/HypC family; Region: HupF_HypC; pfam01455
690850000406	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
690850000407	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
690850000408	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
690850000409	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
690850000410	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
690850000411	ATP-grasp domain; Region: ATP-grasp_4; cl17255
690850000412	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
690850000413	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
690850000414	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
690850000415	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
690850000416	Ligand binding site; other site
690850000417	oligomer interface; other site
690850000418	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
690850000419	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
690850000420	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
690850000421	catalytic site [active]
690850000422	subunit interface [polypeptide binding]; other site
690850000423	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850000424	TPR motif; other site
690850000425	Tetratricopeptide repeat; Region: TPR_12; pfam13424
690850000426	binding surface
690850000427	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
690850000428	NeuB family; Region: NeuB; pfam03102
690850000429	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
690850000430	NeuB binding interface [polypeptide binding]; other site
690850000431	putative substrate binding site [chemical binding]; other site
690850000432	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850000433	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
690850000434	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
690850000435	glycogen branching enzyme; Provisional; Region: PRK12313
690850000436	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
690850000437	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
690850000438	active site
690850000439	catalytic site [active]
690850000440	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
690850000441	N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184
690850000442	glycogen synthase; Provisional; Region: glgA; PRK00654
690850000443	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
690850000444	ADP-binding pocket [chemical binding]; other site
690850000445	homodimer interface [polypeptide binding]; other site
690850000446	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
690850000447	nudix motif; other site
690850000448	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
690850000449	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
690850000450	putative active site [active]
690850000451	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
690850000452	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
690850000453	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
690850000454	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
690850000455	active site
690850000456	C-terminal domain interface [polypeptide binding]; other site
690850000457	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
690850000458	active site
690850000459	N-terminal domain interface [polypeptide binding]; other site
690850000460	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
690850000461	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
690850000462	ABC-ATPase subunit  interface; other site
690850000463	dimer interface [polypeptide binding]; other site
690850000464	putative PBP binding regions; other site
690850000465	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
690850000466	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
690850000467	Walker A/P-loop; other site
690850000468	ATP binding site [chemical binding]; other site
690850000469	Q-loop/lid; other site
690850000470	ABC transporter signature motif; other site
690850000471	Walker B; other site
690850000472	D-loop; other site
690850000473	H-loop/switch region; other site
690850000474	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
690850000475	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
690850000476	intersubunit interface [polypeptide binding]; other site
690850000477	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
690850000478	active site
690850000479	SAM binding site [chemical binding]; other site
690850000480	homodimer interface [polypeptide binding]; other site
690850000481	acetylornithine aminotransferase; Provisional; Region: PRK02627
690850000482	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
690850000483	inhibitor-cofactor binding pocket; inhibition site
690850000484	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850000485	catalytic residue [active]
690850000486	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
690850000487	trimer interface [polypeptide binding]; other site
690850000488	active site
690850000489	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
690850000490	putative homodimer interface [polypeptide binding]; other site
690850000491	putative active site pocket [active]
690850000492	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
690850000493	intracellular protease, PfpI family; Region: PfpI; TIGR01382
690850000494	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
690850000495	proposed catalytic triad [active]
690850000496	conserved cys residue [active]
690850000497	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
690850000498	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850000499	dimerization interface [polypeptide binding]; other site
690850000500	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850000501	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850000502	dimer interface [polypeptide binding]; other site
690850000503	putative CheW interface [polypeptide binding]; other site
690850000504	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
690850000505	dimer interface [polypeptide binding]; other site
690850000506	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
690850000507	YcfA-like protein; Region: YcfA; pfam07927
690850000508	Acylphosphatase; Region: Acylphosphatase; pfam00708
690850000509	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
690850000510	HypF finger; Region: zf-HYPF; pfam07503
690850000511	HypF finger; Region: zf-HYPF; pfam07503
690850000512	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
690850000513	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
690850000514	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
690850000515	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
690850000516	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
690850000517	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
690850000518	active site
690850000519	motif I; other site
690850000520	motif II; other site
690850000521	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
690850000522	methionine sulfoxide reductase B; Provisional; Region: PRK00222
690850000523	SelR domain; Region: SelR; pfam01641
690850000524	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
690850000525	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
690850000526	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
690850000527	rRNA interaction site [nucleotide binding]; other site
690850000528	S8 interaction site; other site
690850000529	putative laminin-1 binding site; other site
690850000530	elongation factor Ts; Provisional; Region: tsf; PRK09377
690850000531	UBA/TS-N domain; Region: UBA; pfam00627
690850000532	Elongation factor TS; Region: EF_TS; pfam00889
690850000533	Elongation factor TS; Region: EF_TS; pfam00889
690850000534	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
690850000535	putative nucleotide binding site [chemical binding]; other site
690850000536	uridine monophosphate binding site [chemical binding]; other site
690850000537	homohexameric interface [polypeptide binding]; other site
690850000538	ribosome recycling factor; Reviewed; Region: frr; PRK00083
690850000539	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
690850000540	hinge region; other site
690850000541	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
690850000542	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
690850000543	catalytic residue [active]
690850000544	putative FPP diphosphate  binding site; other site
690850000545	putative FPP binding hydrophobic cleft; other site
690850000546	dimer interface [polypeptide binding]; other site
690850000547	putative IPP diphosphate binding site; other site
690850000548	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
690850000549	active site
690850000550	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
690850000551	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
690850000552	Cupin domain; Region: Cupin_2; pfam07883
690850000553	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850000554	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850000555	metal binding site [ion binding]; metal-binding site
690850000556	active site
690850000557	I-site; other site
690850000558	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
690850000559	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
690850000560	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
690850000561	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
690850000562	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
690850000563	motif II; other site
690850000564	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
690850000565	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850000566	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850000567	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850000568	LytB protein; Region: LYTB; cl00507
690850000569	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
690850000570	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
690850000571	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850000572	FeS/SAM binding site; other site
690850000573	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
690850000574	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
690850000575	GAF domain; Region: GAF; pfam01590
690850000576	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
690850000577	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
690850000578	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
690850000579	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
690850000580	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
690850000581	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
690850000582	Active site cavity [active]
690850000583	catalytic acid [active]
690850000584	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
690850000585	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
690850000586	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
690850000587	Protein export membrane protein; Region: SecD_SecF; cl14618
690850000588	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
690850000589	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
690850000590	putative NADP binding site [chemical binding]; other site
690850000591	putative substrate binding site [chemical binding]; other site
690850000592	active site
690850000593	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
690850000594	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
690850000595	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
690850000596	type II secretion system protein E; Region: type_II_gspE; TIGR02533
690850000597	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
690850000598	Walker A motif; other site
690850000599	ATP binding site [chemical binding]; other site
690850000600	Walker B motif; other site
690850000601	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
690850000602	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
690850000603	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
690850000604	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
690850000605	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
690850000606	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
690850000607	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
690850000608	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
690850000609	Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
690850000610	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
690850000611	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
690850000612	type II secretion system protein D; Region: type_II_gspD; TIGR02517
690850000613	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
690850000614	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
690850000615	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
690850000616	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
690850000617	ATP binding site [chemical binding]; other site
690850000618	putative Mg++ binding site [ion binding]; other site
690850000619	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
690850000620	nucleotide binding region [chemical binding]; other site
690850000621	ATP-binding site [chemical binding]; other site
690850000622	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
690850000623	HRDC domain; Region: HRDC; pfam00570
690850000624	VacJ like lipoprotein; Region: VacJ; cl01073
690850000625	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
690850000626	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
690850000627	mce related protein; Region: MCE; pfam02470
690850000628	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
690850000629	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
690850000630	Walker A/P-loop; other site
690850000631	ATP binding site [chemical binding]; other site
690850000632	Q-loop/lid; other site
690850000633	ABC transporter signature motif; other site
690850000634	Walker B; other site
690850000635	D-loop; other site
690850000636	H-loop/switch region; other site
690850000637	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850000638	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850000639	metal binding site [ion binding]; metal-binding site
690850000640	active site
690850000641	I-site; other site
690850000642	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
690850000643	Permease; Region: Permease; pfam02405
690850000644	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
690850000645	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
690850000646	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
690850000647	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
690850000648	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
690850000649	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
690850000650	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
690850000651	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
690850000652	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
690850000653	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
690850000654	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
690850000655	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
690850000656	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
690850000657	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
690850000658	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
690850000659	DNA binding site [nucleotide binding]
690850000660	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
690850000661	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
690850000662	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
690850000663	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
690850000664	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
690850000665	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
690850000666	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
690850000667	RPB3 interaction site [polypeptide binding]; other site
690850000668	RPB1 interaction site [polypeptide binding]; other site
690850000669	RPB11 interaction site [polypeptide binding]; other site
690850000670	RPB10 interaction site [polypeptide binding]; other site
690850000671	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
690850000672	core dimer interface [polypeptide binding]; other site
690850000673	peripheral dimer interface [polypeptide binding]; other site
690850000674	L10 interface [polypeptide binding]; other site
690850000675	L11 interface [polypeptide binding]; other site
690850000676	putative EF-Tu interaction site [polypeptide binding]; other site
690850000677	putative EF-G interaction site [polypeptide binding]; other site
690850000678	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
690850000679	23S rRNA interface [nucleotide binding]; other site
690850000680	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
690850000681	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
690850000682	mRNA/rRNA interface [nucleotide binding]; other site
690850000683	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
690850000684	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
690850000685	23S rRNA interface [nucleotide binding]; other site
690850000686	L7/L12 interface [polypeptide binding]; other site
690850000687	putative thiostrepton binding site; other site
690850000688	L25 interface [polypeptide binding]; other site
690850000689	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
690850000690	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
690850000691	putative homodimer interface [polypeptide binding]; other site
690850000692	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
690850000693	heterodimer interface [polypeptide binding]; other site
690850000694	homodimer interface [polypeptide binding]; other site
690850000695	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
690850000696	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
690850000697	elongation factor Tu; Reviewed; Region: PRK00049
690850000698	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
690850000699	G1 box; other site
690850000700	GEF interaction site [polypeptide binding]; other site
690850000701	GTP/Mg2+ binding site [chemical binding]; other site
690850000702	Switch I region; other site
690850000703	G2 box; other site
690850000704	G3 box; other site
690850000705	Switch II region; other site
690850000706	G4 box; other site
690850000707	G5 box; other site
690850000708	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
690850000709	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
690850000710	Antibiotic Binding Site [chemical binding]; other site
690850000711	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
690850000712	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
690850000713	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
690850000714	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850000715	S-adenosylmethionine binding site [chemical binding]; other site
690850000716	peptide chain release factor 1; Validated; Region: prfA; PRK00591
690850000717	This domain is found in peptide chain release factors; Region: PCRF; smart00937
690850000718	RF-1 domain; Region: RF-1; pfam00472
690850000719	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
690850000720	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
690850000721	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
690850000722	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
690850000723	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
690850000724	catalytic core [active]
690850000725	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
690850000726	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
690850000727	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
690850000728	minor groove reading motif; other site
690850000729	helix-hairpin-helix signature motif; other site
690850000730	substrate binding pocket [chemical binding]; other site
690850000731	active site
690850000732	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
690850000733	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
690850000734	active site
690850000735	8-oxo-dGMP binding site [chemical binding]; other site
690850000736	nudix motif; other site
690850000737	metal binding site [ion binding]; metal-binding site
690850000738	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
690850000739	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
690850000740	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
690850000741	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850000742	active site
690850000743	phosphorylation site [posttranslational modification]
690850000744	intermolecular recognition site; other site
690850000745	dimerization interface [polypeptide binding]; other site
690850000746	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
690850000747	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
690850000748	heterodimer interface [polypeptide binding]; other site
690850000749	active site
690850000750	FMN binding site [chemical binding]; other site
690850000751	homodimer interface [polypeptide binding]; other site
690850000752	substrate binding site [chemical binding]; other site
690850000753	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
690850000754	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
690850000755	FAD binding pocket [chemical binding]; other site
690850000756	FAD binding motif [chemical binding]; other site
690850000757	phosphate binding motif [ion binding]; other site
690850000758	beta-alpha-beta structure motif; other site
690850000759	NAD binding pocket [chemical binding]; other site
690850000760	Iron coordination center [ion binding]; other site
690850000761	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
690850000762	Peptidase family U32; Region: Peptidase_U32; pfam01136
690850000763	Peptidase family U32; Region: Peptidase_U32; cl03113
690850000764	Transcriptional regulator [Transcription]; Region: LysR; COG0583
690850000765	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
690850000766	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
690850000767	dimerization interface [polypeptide binding]; other site
690850000768	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
690850000769	EamA-like transporter family; Region: EamA; pfam00892
690850000770	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
690850000771	EamA-like transporter family; Region: EamA; pfam00892
690850000772	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
690850000773	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
690850000774	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
690850000775	Flagellin N-methylase; Region: FliB; cl00497
690850000776	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
690850000777	Transglycosylase; Region: Transgly; pfam00912
690850000778	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
690850000779	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
690850000780	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
690850000781	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
690850000782	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
690850000783	FAD binding pocket [chemical binding]; other site
690850000784	FAD binding motif [chemical binding]; other site
690850000785	phosphate binding motif [ion binding]; other site
690850000786	beta-alpha-beta structure motif; other site
690850000787	NAD binding pocket [chemical binding]; other site
690850000788	Cytochrome c; Region: Cytochrom_C; pfam00034
690850000789	Homeodomain-like domain; Region: HTH_23; pfam13384
690850000790	Winged helix-turn helix; Region: HTH_29; pfam13551
690850000791	Homeodomain-like domain; Region: HTH_32; pfam13565
690850000792	DDE superfamily endonuclease; Region: DDE_3; pfam13358
690850000793	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
690850000794	AIR carboxylase; Region: AIRC; pfam00731
690850000795	Cupin domain; Region: Cupin_2; cl17218
690850000796	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
690850000797	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
690850000798	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
690850000799	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
690850000800	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
690850000801	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
690850000802	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
690850000803	Cache domain; Region: Cache_1; pfam02743
690850000804	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850000805	dimerization interface [polypeptide binding]; other site
690850000806	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850000807	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850000808	dimer interface [polypeptide binding]; other site
690850000809	putative CheW interface [polypeptide binding]; other site
690850000810	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
690850000811	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
690850000812	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
690850000813	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
690850000814	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
690850000815	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
690850000816	Double zinc ribbon; Region: DZR; pfam12773
690850000817	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
690850000818	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
690850000819	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
690850000820	AMIN domain; Region: AMIN; pfam11741
690850000821	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
690850000822	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
690850000823	AsnC family; Region: AsnC_trans_reg; pfam01037
690850000824	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850000825	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850000826	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850000827	PAS domain; Region: PAS_9; pfam13426
690850000828	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850000829	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850000830	putative active site [active]
690850000831	heme pocket [chemical binding]; other site
690850000832	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850000833	dimer interface [polypeptide binding]; other site
690850000834	phosphorylation site [posttranslational modification]
690850000835	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850000836	ATP binding site [chemical binding]; other site
690850000837	Mg2+ binding site [ion binding]; other site
690850000838	G-X-G motif; other site
690850000839	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850000840	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850000841	active site
690850000842	phosphorylation site [posttranslational modification]
690850000843	intermolecular recognition site; other site
690850000844	dimerization interface [polypeptide binding]; other site
690850000845	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
690850000846	Peptidase family M48; Region: Peptidase_M48; pfam01435
690850000847	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
690850000848	active site
690850000849	Protein of unknown function (DUF1018); Region: DUF1018; cl01815
690850000850	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
690850000851	non-specific DNA binding site [nucleotide binding]; other site
690850000852	salt bridge; other site
690850000853	Predicted transcriptional regulator [Transcription]; Region: COG2932
690850000854	sequence-specific DNA binding site [nucleotide binding]; other site
690850000855	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
690850000856	Catalytic site [active]
690850000857	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
690850000858	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850000859	dimer interface [polypeptide binding]; other site
690850000860	phosphorylation site [posttranslational modification]
690850000861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850000862	ATP binding site [chemical binding]; other site
690850000863	Mg2+ binding site [ion binding]; other site
690850000864	G-X-G motif; other site
690850000865	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850000866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850000867	active site
690850000868	phosphorylation site [posttranslational modification]
690850000869	intermolecular recognition site; other site
690850000870	dimerization interface [polypeptide binding]; other site
690850000871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850000872	Walker A motif; other site
690850000873	ATP binding site [chemical binding]; other site
690850000874	Walker B motif; other site
690850000875	arginine finger; other site
690850000876	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850000877	Vitamin K epoxide reductase (VKOR) family in bacteria; Region: VKOR_4; cd12921
690850000878	putative active site [active]
690850000879	redox center [active]
690850000880	Thioredoxin; Region: Thioredoxin_4; cl17273
690850000881	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
690850000882	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
690850000883	TrkA-N domain; Region: TrkA_N; pfam02254
690850000884	TrkA-C domain; Region: TrkA_C; pfam02080
690850000885	TrkA-N domain; Region: TrkA_N; pfam02254
690850000886	TrkA-C domain; Region: TrkA_C; pfam02080
690850000887	Cation transport protein; Region: TrkH; cl17365
690850000888	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
690850000889	Isochorismatase family; Region: Isochorismatase; pfam00857
690850000890	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
690850000891	catalytic triad [active]
690850000892	conserved cis-peptide bond; other site
690850000893	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850000894	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850000895	metal binding site [ion binding]; metal-binding site
690850000896	active site
690850000897	I-site; other site
690850000898	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
690850000899	Protein of unknown function (DUF3568); Region: DUF3568; pfam12092
690850000900	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850000901	PAS fold; Region: PAS_3; pfam08447
690850000902	putative active site [active]
690850000903	heme pocket [chemical binding]; other site
690850000904	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850000905	PAS domain; Region: PAS_9; pfam13426
690850000906	putative active site [active]
690850000907	heme pocket [chemical binding]; other site
690850000908	PAS fold; Region: PAS_4; pfam08448
690850000909	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850000910	putative active site [active]
690850000911	heme pocket [chemical binding]; other site
690850000912	PAS fold; Region: PAS_4; pfam08448
690850000913	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850000914	PAS domain; Region: PAS_9; pfam13426
690850000915	putative active site [active]
690850000916	heme pocket [chemical binding]; other site
690850000917	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850000918	dimer interface [polypeptide binding]; other site
690850000919	phosphorylation site [posttranslational modification]
690850000920	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850000921	ATP binding site [chemical binding]; other site
690850000922	Mg2+ binding site [ion binding]; other site
690850000923	G-X-G motif; other site
690850000924	ABC transporter ATPase component; Reviewed; Region: PRK11147
690850000925	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850000926	Walker A/P-loop; other site
690850000927	ATP binding site [chemical binding]; other site
690850000928	Q-loop/lid; other site
690850000929	ABC transporter signature motif; other site
690850000930	Walker B; other site
690850000931	D-loop; other site
690850000932	H-loop/switch region; other site
690850000933	ABC transporter; Region: ABC_tran_2; pfam12848
690850000934	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
690850000935	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
690850000936	transketolase; Reviewed; Region: PRK05899
690850000937	TPP-binding site [chemical binding]; other site
690850000938	dimer interface [polypeptide binding]; other site
690850000939	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
690850000940	PYR/PP interface [polypeptide binding]; other site
690850000941	dimer interface [polypeptide binding]; other site
690850000942	TPP binding site [chemical binding]; other site
690850000943	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
690850000944	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
690850000945	putative active site [active]
690850000946	transaldolase; Provisional; Region: PRK03903
690850000947	catalytic residue [active]
690850000948	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
690850000949	tetramer (dimer of dimers) interface [polypeptide binding]; other site
690850000950	active site
690850000951	dimer interface [polypeptide binding]; other site
690850000952	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
690850000953	Moco binding site; other site
690850000954	metal coordination site [ion binding]; other site
690850000955	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
690850000956	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
690850000957	active site
690850000958	DNA binding site [nucleotide binding]
690850000959	DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776
690850000960	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
690850000961	DNA binding site [nucleotide binding]
690850000962	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
690850000963	nucleotide binding site [chemical binding]; other site
690850000964	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
690850000965	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
690850000966	putative DNA binding site [nucleotide binding]; other site
690850000967	putative homodimer interface [polypeptide binding]; other site
690850000968	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
690850000969	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
690850000970	active site
690850000971	DNA binding site [nucleotide binding]
690850000972	Int/Topo IB signature motif; other site
690850000973	catalytic residues [active]
690850000974	thioredoxin 2; Provisional; Region: PRK10996
690850000975	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
690850000976	catalytic residues [active]
690850000977	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
690850000978	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
690850000979	Fe-S cluster binding site [ion binding]; other site
690850000980	active site
690850000981	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
690850000982	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850000983	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790
690850000984	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
690850000985	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
690850000986	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
690850000987	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
690850000988	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
690850000989	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
690850000990	CoA binding domain; Region: CoA_binding_2; pfam13380
690850000991	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
690850000992	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
690850000993	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
690850000994	acetyl-CoA synthetase; Provisional; Region: PRK00174
690850000995	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
690850000996	active site
690850000997	CoA binding site [chemical binding]; other site
690850000998	acyl-activating enzyme (AAE) consensus motif; other site
690850000999	AMP binding site [chemical binding]; other site
690850001000	acetate binding site [chemical binding]; other site
690850001001	TPR repeat; Region: TPR_11; pfam13414
690850001002	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850001003	TPR motif; other site
690850001004	binding surface
690850001005	TPR repeat; Region: TPR_11; pfam13414
690850001006	TPR repeat; Region: TPR_11; pfam13414
690850001007	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850001008	TPR motif; other site
690850001009	binding surface
690850001010	Uncharacterized conserved protein [Function unknown]; Region: COG3379
690850001011	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
690850001012	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
690850001013	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
690850001014	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
690850001015	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
690850001016	Walker A/P-loop; other site
690850001017	ATP binding site [chemical binding]; other site
690850001018	Q-loop/lid; other site
690850001019	ABC transporter signature motif; other site
690850001020	Walker B; other site
690850001021	D-loop; other site
690850001022	H-loop/switch region; other site
690850001023	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
690850001024	TM-ABC transporter signature motif; other site
690850001025	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
690850001026	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
690850001027	TM-ABC transporter signature motif; other site
690850001028	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
690850001029	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
690850001030	dimerization interface [polypeptide binding]; other site
690850001031	ligand binding site [chemical binding]; other site
690850001032	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
690850001033	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
690850001034	Walker A/P-loop; other site
690850001035	ATP binding site [chemical binding]; other site
690850001036	Q-loop/lid; other site
690850001037	ABC transporter signature motif; other site
690850001038	Walker B; other site
690850001039	D-loop; other site
690850001040	H-loop/switch region; other site
690850001041	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
690850001042	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
690850001043	tricarballylate utilization protein B; Provisional; Region: PRK15033
690850001044	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
690850001045	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
690850001046	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
690850001047	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
690850001048	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
690850001049	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
690850001050	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
690850001051	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
690850001052	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
690850001053	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
690850001054	adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060
690850001055	Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139
690850001056	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
690850001057	Ligand Binding Site [chemical binding]; other site
690850001058	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
690850001059	active site
690850001060	ATP binding site [chemical binding]; other site
690850001061	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
690850001062	substrate binding site [chemical binding]; other site
690850001063	activation loop (A-loop); other site
690850001064	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
690850001065	ATP-sulfurylase; Region: ATPS; cd00517
690850001066	active site
690850001067	HXXH motif; other site
690850001068	flexible loop; other site
690850001069	aconitate hydratase; Validated; Region: PRK07229
690850001070	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
690850001071	substrate binding site [chemical binding]; other site
690850001072	ligand binding site [chemical binding]; other site
690850001073	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
690850001074	substrate binding site [chemical binding]; other site
690850001075	periplasmic folding chaperone; Provisional; Region: PRK10788
690850001076	SurA N-terminal domain; Region: SurA_N_3; cl07813
690850001077	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
690850001078	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
690850001079	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
690850001080	active site
690850001081	metal binding site [ion binding]; metal-binding site
690850001082	homotetramer interface [polypeptide binding]; other site
690850001083	HD domain; Region: HD_3; pfam13023
690850001084	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
690850001085	heterotetramer interface [polypeptide binding]; other site
690850001086	active site pocket [active]
690850001087	cleavage site
690850001088	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
690850001089	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
690850001090	MarR family; Region: MarR; pfam01047
690850001091	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
690850001092	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
690850001093	HlyD family secretion protein; Region: HlyD_3; pfam13437
690850001094	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
690850001095	Protein export membrane protein; Region: SecD_SecF; cl14618
690850001096	Uncharacterized conserved protein [Function unknown]; Region: COG2155
690850001097	3D domain; Region: 3D; cl01439
690850001098	Protein of unknown function (DUF1614); Region: DUF1614; pfam07758
690850001099	Protein of unknown function (DUF523); Region: DUF523; pfam04463
690850001100	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
690850001101	MPT binding site; other site
690850001102	trimer interface [polypeptide binding]; other site
690850001103	PAS domain S-box; Region: sensory_box; TIGR00229
690850001104	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850001105	putative active site [active]
690850001106	heme pocket [chemical binding]; other site
690850001107	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850001108	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850001109	putative active site [active]
690850001110	heme pocket [chemical binding]; other site
690850001111	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850001112	putative active site [active]
690850001113	heme pocket [chemical binding]; other site
690850001114	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850001115	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850001116	putative active site [active]
690850001117	heme pocket [chemical binding]; other site
690850001118	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850001119	dimer interface [polypeptide binding]; other site
690850001120	phosphorylation site [posttranslational modification]
690850001121	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850001122	ATP binding site [chemical binding]; other site
690850001123	Mg2+ binding site [ion binding]; other site
690850001124	G-X-G motif; other site
690850001125	Response regulator receiver domain; Region: Response_reg; pfam00072
690850001126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850001127	active site
690850001128	phosphorylation site [posttranslational modification]
690850001129	intermolecular recognition site; other site
690850001130	dimerization interface [polypeptide binding]; other site
690850001131	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
690850001132	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850001133	active site
690850001134	phosphorylation site [posttranslational modification]
690850001135	intermolecular recognition site; other site
690850001136	dimerization interface [polypeptide binding]; other site
690850001137	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
690850001138	DNA binding site [nucleotide binding]
690850001139	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
690850001140	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
690850001141	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
690850001142	DNA binding residues [nucleotide binding]
690850001143	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
690850001144	transmembrane helices; other site
690850001145	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
690850001146	PAS domain S-box; Region: sensory_box; TIGR00229
690850001147	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
690850001148	putative active site [active]
690850001149	heme pocket [chemical binding]; other site
690850001150	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850001151	PAS domain; Region: PAS_9; pfam13426
690850001152	putative active site [active]
690850001153	heme pocket [chemical binding]; other site
690850001154	PAS fold; Region: PAS_4; pfam08448
690850001155	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850001156	putative active site [active]
690850001157	heme pocket [chemical binding]; other site
690850001158	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850001159	dimer interface [polypeptide binding]; other site
690850001160	phosphorylation site [posttranslational modification]
690850001161	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850001162	ATP binding site [chemical binding]; other site
690850001163	Mg2+ binding site [ion binding]; other site
690850001164	G-X-G motif; other site
690850001165	Response regulator receiver domain; Region: Response_reg; pfam00072
690850001166	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850001167	active site
690850001168	phosphorylation site [posttranslational modification]
690850001169	intermolecular recognition site; other site
690850001170	dimerization interface [polypeptide binding]; other site
690850001171	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
690850001172	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
690850001173	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
690850001174	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
690850001175	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
690850001176	DNA binding residues [nucleotide binding]
690850001177	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
690850001178	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
690850001179	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
690850001180	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
690850001181	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
690850001182	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
690850001183	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
690850001184	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
690850001185	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
690850001186	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
690850001187	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
690850001188	Putative zinc-finger; Region: zf-HC2; pfam13490
690850001189	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
690850001190	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
690850001191	Family description; Region: UvrD_C_2; pfam13538
690850001192	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283
690850001193	DHH family; Region: DHH; pfam01368
690850001194	5'-3' exonuclease; Region: 53EXOc; smart00475
690850001195	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
690850001196	active site
690850001197	metal binding site 1 [ion binding]; metal-binding site
690850001198	putative 5' ssDNA interaction site; other site
690850001199	metal binding site 3; metal-binding site
690850001200	metal binding site 2 [ion binding]; metal-binding site
690850001201	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
690850001202	putative DNA binding site [nucleotide binding]; other site
690850001203	putative metal binding site [ion binding]; other site
690850001204	DNA polymerase I; Provisional; Region: PRK05755
690850001205	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
690850001206	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
690850001207	active site
690850001208	DNA binding site [nucleotide binding]
690850001209	catalytic site [active]
690850001210	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
690850001211	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
690850001212	active site
690850001213	NTP binding site [chemical binding]; other site
690850001214	nucleic acid binding site [nucleotide binding]; other site
690850001215	RES domain; Region: RES; pfam08808
690850001216	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
690850001217	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
690850001218	catalytic residue [active]
690850001219	Domain of unknown function (DUF1844); Region: DUF1844; pfam08899
690850001220	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
690850001221	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
690850001222	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
690850001223	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
690850001224	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
690850001225	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
690850001226	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
690850001227	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
690850001228	Walker A/P-loop; other site
690850001229	ATP binding site [chemical binding]; other site
690850001230	Q-loop/lid; other site
690850001231	ABC transporter signature motif; other site
690850001232	Walker B; other site
690850001233	D-loop; other site
690850001234	H-loop/switch region; other site
690850001235	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
690850001236	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
690850001237	Walker A/P-loop; other site
690850001238	ATP binding site [chemical binding]; other site
690850001239	Q-loop/lid; other site
690850001240	ABC transporter signature motif; other site
690850001241	Walker B; other site
690850001242	D-loop; other site
690850001243	H-loop/switch region; other site
690850001244	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
690850001245	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
690850001246	HlyD family secretion protein; Region: HlyD_3; pfam13437
690850001247	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
690850001248	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
690850001249	PRC-barrel domain; Region: PRC; pfam05239
690850001250	PRC-barrel domain; Region: PRC; pfam05239
690850001251	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
690850001252	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
690850001253	acyl-activating enzyme (AAE) consensus motif; other site
690850001254	AMP binding site [chemical binding]; other site
690850001255	active site
690850001256	CoA binding site [chemical binding]; other site
690850001257	PilZ domain; Region: PilZ; pfam07238
690850001258	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
690850001259	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
690850001260	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
690850001261	putative dimer interface [polypeptide binding]; other site
690850001262	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
690850001263	DNA polymerase III subunit delta'; Validated; Region: PRK08485
690850001264	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
690850001265	HEAT repeats; Region: HEAT_2; pfam13646
690850001266	HEAT repeats; Region: HEAT_2; pfam13646
690850001267	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
690850001268	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
690850001269	acyl-activating enzyme (AAE) consensus motif; other site
690850001270	AMP binding site [chemical binding]; other site
690850001271	active site
690850001272	CoA binding site [chemical binding]; other site
690850001273	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964
690850001274	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850001275	FeS/SAM binding site; other site
690850001276	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
690850001277	Methyltransferase domain; Region: Methyltransf_31; pfam13847
690850001278	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850001279	S-adenosylmethionine binding site [chemical binding]; other site
690850001280	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
690850001281	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
690850001282	Cysteine-rich domain; Region: CCG; pfam02754
690850001283	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
690850001284	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
690850001285	catalytic loop [active]
690850001286	iron binding site [ion binding]; other site
690850001287	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
690850001288	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
690850001289	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
690850001290	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
690850001291	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
690850001292	putative MPT binding site; other site
690850001293	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
690850001294	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
690850001295	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
690850001296	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
690850001297	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
690850001298	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
690850001299	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
690850001300	[4Fe-4S] binding site [ion binding]; other site
690850001301	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
690850001302	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
690850001303	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
690850001304	molybdopterin cofactor binding site; other site
690850001305	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
690850001306	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
690850001307	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
690850001308	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
690850001309	DctM-like transporters; Region: DctM; pfam06808
690850001310	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
690850001311	Flagellin N-methylase; Region: FliB; cl00497
690850001312	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
690850001313	active site
690850001314	Predicted membrane protein [Function unknown]; Region: COG3671
690850001315	CHAT domain; Region: CHAT; pfam12770
690850001316	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
690850001317	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
690850001318	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
690850001319	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
690850001320	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
690850001321	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
690850001322	putative NAD(P) binding site [chemical binding]; other site
690850001323	putative active site [active]
690850001324	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
690850001325	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
690850001326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850001327	active site
690850001328	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850001329	phosphorylation site [posttranslational modification]
690850001330	intermolecular recognition site; other site
690850001331	dimerization interface [polypeptide binding]; other site
690850001332	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850001333	Walker A motif; other site
690850001334	ATP binding site [chemical binding]; other site
690850001335	Walker B motif; other site
690850001336	arginine finger; other site
690850001337	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
690850001338	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850001339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850001340	active site
690850001341	phosphorylation site [posttranslational modification]
690850001342	intermolecular recognition site; other site
690850001343	dimerization interface [polypeptide binding]; other site
690850001344	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850001345	Walker A motif; other site
690850001346	ATP binding site [chemical binding]; other site
690850001347	Walker B motif; other site
690850001348	arginine finger; other site
690850001349	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
690850001350	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
690850001351	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850001352	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850001353	dimer interface [polypeptide binding]; other site
690850001354	phosphorylation site [posttranslational modification]
690850001355	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850001356	ATP binding site [chemical binding]; other site
690850001357	Mg2+ binding site [ion binding]; other site
690850001358	G-X-G motif; other site
690850001359	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
690850001360	heme-binding residues [chemical binding]; other site
690850001361	OsmC-like protein; Region: OsmC; pfam02566
690850001362	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
690850001363	heme-binding residues [chemical binding]; other site
690850001364	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
690850001365	Cysteine-rich domain; Region: CCG; pfam02754
690850001366	FOG: WD40 repeat [General function prediction only]; Region: COG2319
690850001367	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
690850001368	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
690850001369	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850001370	Walker A/P-loop; other site
690850001371	ATP binding site [chemical binding]; other site
690850001372	Q-loop/lid; other site
690850001373	ABC transporter signature motif; other site
690850001374	Walker B; other site
690850001375	D-loop; other site
690850001376	H-loop/switch region; other site
690850001377	Protein of unknown function, DUF399; Region: DUF399; pfam04187
690850001378	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
690850001379	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
690850001380	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
690850001381	acyl-activating enzyme (AAE) consensus motif; other site
690850001382	AMP binding site [chemical binding]; other site
690850001383	active site
690850001384	CoA binding site [chemical binding]; other site
690850001385	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
690850001386	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
690850001387	Radical SAM superfamily; Region: Radical_SAM; pfam04055
690850001388	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850001389	FeS/SAM binding site; other site
690850001390	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
690850001391	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
690850001392	homodimer interface [polypeptide binding]; other site
690850001393	oligonucleotide binding site [chemical binding]; other site
690850001394	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
690850001395	Ligand Binding Site [chemical binding]; other site
690850001396	TPR repeat; Region: TPR_11; pfam13414
690850001397	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850001398	binding surface
690850001399	TPR motif; other site
690850001400	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
690850001401	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850001402	FeS/SAM binding site; other site
690850001403	HemN C-terminal domain; Region: HemN_C; pfam06969
690850001404	Sensory domain found in PocR; Region: PocR; pfam10114
690850001405	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850001406	PAS domain; Region: PAS_9; pfam13426
690850001407	putative active site [active]
690850001408	heme pocket [chemical binding]; other site
690850001409	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850001410	PAS fold; Region: PAS_3; pfam08447
690850001411	putative active site [active]
690850001412	heme pocket [chemical binding]; other site
690850001413	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850001414	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850001415	dimer interface [polypeptide binding]; other site
690850001416	phosphorylation site [posttranslational modification]
690850001417	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850001418	ATP binding site [chemical binding]; other site
690850001419	Mg2+ binding site [ion binding]; other site
690850001420	G-X-G motif; other site
690850001421	Response regulator receiver domain; Region: Response_reg; pfam00072
690850001422	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850001423	active site
690850001424	phosphorylation site [posttranslational modification]
690850001425	intermolecular recognition site; other site
690850001426	dimerization interface [polypeptide binding]; other site
690850001427	PBP superfamily domain; Region: PBP_like_2; pfam12849
690850001428	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
690850001429	Type III pantothenate kinase; Region: Pan_kinase; cl17198
690850001430	enolase; Provisional; Region: eno; PRK00077
690850001431	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
690850001432	dimer interface [polypeptide binding]; other site
690850001433	metal binding site [ion binding]; metal-binding site
690850001434	substrate binding pocket [chemical binding]; other site
690850001435	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
690850001436	SnoaL-like domain; Region: SnoaL_3; pfam13474
690850001437	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14184
690850001438	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
690850001439	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
690850001440	homodimer interface [polypeptide binding]; other site
690850001441	NADP binding site [chemical binding]; other site
690850001442	substrate binding site [chemical binding]; other site
690850001443	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
690850001444	substrate binding site [chemical binding]; other site
690850001445	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
690850001446	A new structural DNA glycosylase; Region: AlkD_like; cd06561
690850001447	active site
690850001448	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
690850001449	ABC1 family; Region: ABC1; cl17513
690850001450	Uncharacterized conserved protein [Function unknown]; Region: COG3937
690850001451	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
690850001452	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
690850001453	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
690850001454	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
690850001455	Domain of unknown function (DUF386); Region: DUF386; cl01047
690850001456	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
690850001457	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
690850001458	FtsX-like permease family; Region: FtsX; pfam02687
690850001459	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
690850001460	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
690850001461	Walker A/P-loop; other site
690850001462	ATP binding site [chemical binding]; other site
690850001463	Q-loop/lid; other site
690850001464	ABC transporter signature motif; other site
690850001465	Walker B; other site
690850001466	D-loop; other site
690850001467	H-loop/switch region; other site
690850001468	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
690850001469	active site residue [active]
690850001470	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
690850001471	dinuclear metal binding motif [ion binding]; other site
690850001472	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
690850001473	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
690850001474	HlyD family secretion protein; Region: HlyD_3; pfam13437
690850001475	phosphoglucomutase; Validated; Region: PRK07564
690850001476	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
690850001477	active site
690850001478	substrate binding site [chemical binding]; other site
690850001479	metal binding site [ion binding]; metal-binding site
690850001480	HflK protein; Region: hflK; TIGR01933
690850001481	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
690850001482	FtsH protease regulator HflC; Provisional; Region: PRK11029
690850001483	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
690850001484	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
690850001485	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
690850001486	Catalytic site [active]
690850001487	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
690850001488	oligomerization interface [polypeptide binding]; other site
690850001489	active site
690850001490	metal binding site [ion binding]; metal-binding site
690850001491	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG3366
690850001492	TLC ATP/ADP transporter; Region: TLC; cl03940
690850001493	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
690850001494	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
690850001495	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
690850001496	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850001497	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
690850001498	Coenzyme A binding pocket [chemical binding]; other site
690850001499	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
690850001500	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
690850001501	Uncharacterized conserved protein [Function unknown]; Region: COG1434
690850001502	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
690850001503	putative active site [active]
690850001504	aspartate aminotransferase; Provisional; Region: PRK05764
690850001505	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
690850001506	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850001507	homodimer interface [polypeptide binding]; other site
690850001508	catalytic residue [active]
690850001509	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
690850001510	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
690850001511	RNA/DNA hybrid binding site [nucleotide binding]; other site
690850001512	active site
690850001513	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
690850001514	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
690850001515	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936
690850001516	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
690850001517	RimM N-terminal domain; Region: RimM; pfam01782
690850001518	PRC-barrel domain; Region: PRC; pfam05239
690850001519	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
690850001520	hypothetical protein; Provisional; Region: PRK00468
690850001521	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
690850001522	signal recognition particle protein; Provisional; Region: PRK10867
690850001523	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
690850001524	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
690850001525	P loop; other site
690850001526	GTP binding site [chemical binding]; other site
690850001527	Signal peptide binding domain; Region: SRP_SPB; pfam02978
690850001528	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
690850001529	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
690850001530	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
690850001531	active site
690850001532	Zn binding site [ion binding]; other site
690850001533	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
690850001534	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
690850001535	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
690850001536	Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521
690850001537	active site residue [active]
690850001538	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
690850001539	YcaO-like family; Region: YcaO; pfam02624
690850001540	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
690850001541	Na binding site [ion binding]; other site
690850001542	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
690850001543	substrate binding site [chemical binding]; other site
690850001544	multimerization interface [polypeptide binding]; other site
690850001545	ATP binding site [chemical binding]; other site
690850001546	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
690850001547	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
690850001548	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850001549	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850001550	dimerization interface [polypeptide binding]; other site
690850001551	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850001552	dimer interface [polypeptide binding]; other site
690850001553	phosphorylation site [posttranslational modification]
690850001554	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850001555	ATP binding site [chemical binding]; other site
690850001556	Mg2+ binding site [ion binding]; other site
690850001557	G-X-G motif; other site
690850001558	Uncharacterized conserved protein [Function unknown]; Region: COG4850
690850001559	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
690850001560	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
690850001561	Nif-specific regulatory protein; Region: nifA; TIGR01817
690850001562	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
690850001563	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850001564	Walker A motif; other site
690850001565	ATP binding site [chemical binding]; other site
690850001566	Walker B motif; other site
690850001567	arginine finger; other site
690850001568	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850001569	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
690850001570	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
690850001571	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
690850001572	Methyltransferase domain; Region: Methyltransf_31; pfam13847
690850001573	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850001574	S-adenosylmethionine binding site [chemical binding]; other site
690850001575	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
690850001576	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
690850001577	inhibitor-cofactor binding pocket; inhibition site
690850001578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850001579	catalytic residue [active]
690850001580	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
690850001581	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
690850001582	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
690850001583	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
690850001584	Cupin domain; Region: Cupin_2; cl17218
690850001585	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
690850001586	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
690850001587	active site
690850001588	motif I; other site
690850001589	motif II; other site
690850001590	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
690850001591	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
690850001592	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
690850001593	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
690850001594	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
690850001595	motif II; other site
690850001596	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
690850001597	active site
690850001598	Int/Topo IB signature motif; other site
690850001599	molybdenum-pterin binding domain; Region: Mop; TIGR00638
690850001600	TOBE domain; Region: TOBE; cl01440
690850001601	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
690850001602	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
690850001603	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
690850001604	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
690850001605	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
690850001606	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
690850001607	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
690850001608	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
690850001609	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
690850001610	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
690850001611	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
690850001612	putative active site [active]
690850001613	catalytic site [active]
690850001614	Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161
690850001615	putative active site [active]
690850001616	catalytic site [active]
690850001617	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
690850001618	Major Facilitator Superfamily; Region: MFS_1; pfam07690
690850001619	putative substrate translocation pore; other site
690850001620	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
690850001621	arginine decarboxylase; Provisional; Region: PRK05354
690850001622	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
690850001623	dimer interface [polypeptide binding]; other site
690850001624	active site
690850001625	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
690850001626	catalytic residues [active]
690850001627	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
690850001628	Domain of unknown function (DUF389); Region: DUF389; pfam04087
690850001629	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
690850001630	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
690850001631	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
690850001632	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
690850001633	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
690850001634	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
690850001635	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
690850001636	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
690850001637	dimer interface [polypeptide binding]; other site
690850001638	active site
690850001639	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
690850001640	catalytic residues [active]
690850001641	substrate binding site [chemical binding]; other site
690850001642	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
690850001643	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
690850001644	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
690850001645	dimer interface [polypeptide binding]; other site
690850001646	motif 1; other site
690850001647	active site
690850001648	motif 2; other site
690850001649	motif 3; other site
690850001650	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
690850001651	anticodon binding site; other site
690850001652	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
690850001653	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
690850001654	dimer interface [polypeptide binding]; other site
690850001655	anticodon binding site; other site
690850001656	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
690850001657	homodimer interface [polypeptide binding]; other site
690850001658	motif 1; other site
690850001659	active site
690850001660	motif 2; other site
690850001661	GAD domain; Region: GAD; pfam02938
690850001662	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
690850001663	motif 3; other site
690850001664	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
690850001665	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
690850001666	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850001667	S-adenosylmethionine binding site [chemical binding]; other site
690850001668	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850001669	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850001670	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
690850001671	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850001672	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
690850001673	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
690850001674	active site residue [active]
690850001675	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
690850001676	EF-hand domain pair; Region: EF_hand_5; pfam13499
690850001677	Ca2+ binding site [ion binding]; other site
690850001678	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
690850001679	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
690850001680	tetramer interface [polypeptide binding]; other site
690850001681	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850001682	catalytic residue [active]
690850001683	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
690850001684	active site
690850001685	catalytic triad [active]
690850001686	oxyanion hole [active]
690850001687	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850001688	ATP binding site [chemical binding]; other site
690850001689	Walker B; other site
690850001690	D-loop; other site
690850001691	H-loop/switch region; other site
690850001692	CAAX protease self-immunity; Region: Abi; pfam02517
690850001693	Septum formation initiator; Region: DivIC; cl17659
690850001694	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
690850001695	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
690850001696	active site
690850001697	metal binding site [ion binding]; metal-binding site
690850001698	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
690850001699	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850001700	AAA domain; Region: AAA_23; pfam13476
690850001701	Walker A/P-loop; other site
690850001702	ATP binding site [chemical binding]; other site
690850001703	Q-loop/lid; other site
690850001704	Protein of unknown function (DUF3795); Region: DUF3795; pfam12675
690850001705	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
690850001706	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850001707	S-adenosylmethionine binding site [chemical binding]; other site
690850001708	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
690850001709	Uncharacterized conserved protein [Function unknown]; Region: COG4198
690850001710	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
690850001711	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
690850001712	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
690850001713	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
690850001714	DNA binding site [nucleotide binding]
690850001715	catalytic residue [active]
690850001716	H2TH interface [polypeptide binding]; other site
690850001717	putative catalytic residues [active]
690850001718	turnover-facilitating residue; other site
690850001719	intercalation triad [nucleotide binding]; other site
690850001720	8OG recognition residue [nucleotide binding]; other site
690850001721	putative reading head residues; other site
690850001722	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
690850001723	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
690850001724	CheD chemotactic sensory transduction; Region: CheD; cl00810
690850001725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850001726	Response regulator receiver domain; Region: Response_reg; pfam00072
690850001727	active site
690850001728	phosphorylation site [posttranslational modification]
690850001729	intermolecular recognition site; other site
690850001730	dimerization interface [polypeptide binding]; other site
690850001731	HDOD domain; Region: HDOD; pfam08668
690850001732	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850001733	Zn2+ binding site [ion binding]; other site
690850001734	Mg2+ binding site [ion binding]; other site
690850001735	CheD chemotactic sensory transduction; Region: CheD; cl00810
690850001736	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850001737	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
690850001738	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
690850001739	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
690850001740	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
690850001741	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
690850001742	NADH dehydrogenase; Region: NADHdh; cl00469
690850001743	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
690850001744	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
690850001745	Domain of unknown function (DUF4130; Region: DUF4130; cl14836
690850001746	Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277
690850001747	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850001748	FeS/SAM binding site; other site
690850001749	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
690850001750	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850001751	Zn2+ binding site [ion binding]; other site
690850001752	Mg2+ binding site [ion binding]; other site
690850001753	thiamine monophosphate kinase; Provisional; Region: PRK05731
690850001754	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
690850001755	ATP binding site [chemical binding]; other site
690850001756	dimerization interface [polypeptide binding]; other site
690850001757	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
690850001758	homodimer interaction site [polypeptide binding]; other site
690850001759	cofactor binding site; other site
690850001760	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
690850001761	intersubunit interface [polypeptide binding]; other site
690850001762	active site
690850001763	Zn2+ binding site [ion binding]; other site
690850001764	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850001765	Zn2+ binding site [ion binding]; other site
690850001766	Mg2+ binding site [ion binding]; other site
690850001767	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
690850001768	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
690850001769	NAD binding site [chemical binding]; other site
690850001770	dimer interface [polypeptide binding]; other site
690850001771	substrate binding site [chemical binding]; other site
690850001772	tetramer (dimer of dimers) interface [polypeptide binding]; other site
690850001773	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
690850001774	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
690850001775	transmembrane helices; other site
690850001776	Isochorismatase family; Region: Isochorismatase; pfam00857
690850001777	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
690850001778	catalytic triad [active]
690850001779	conserved cis-peptide bond; other site
690850001780	Protein of unknown function (DUF2959); Region: DUF2959; pfam11172
690850001781	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
690850001782	active site residue [active]
690850001783	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
690850001784	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
690850001785	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850001786	Zn2+ binding site [ion binding]; other site
690850001787	Mg2+ binding site [ion binding]; other site
690850001788	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
690850001789	Na binding site [ion binding]; other site
690850001790	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
690850001791	S-formylglutathione hydrolase; Region: PLN02442
690850001792	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
690850001793	Protein of unknown function DUF72; Region: DUF72; pfam01904
690850001794	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
690850001795	Rubredoxin [Energy production and conversion]; Region: COG1773
690850001796	iron binding site [ion binding]; other site
690850001797	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
690850001798	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
690850001799	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
690850001800	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
690850001801	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
690850001802	active site residue [active]
690850001803	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
690850001804	homodimer interaction site [polypeptide binding]; other site
690850001805	cofactor binding site; other site
690850001806	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
690850001807	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
690850001808	active site
690850001809	NAD binding site [chemical binding]; other site
690850001810	metal binding site [ion binding]; metal-binding site
690850001811	PAS domain S-box; Region: sensory_box; TIGR00229
690850001812	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
690850001813	Histidine kinase; Region: HisKA_2; pfam07568
690850001814	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850001815	ATP binding site [chemical binding]; other site
690850001816	Mg2+ binding site [ion binding]; other site
690850001817	G-X-G motif; other site
690850001818	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
690850001819	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
690850001820	putative dimer interface [polypeptide binding]; other site
690850001821	AAA domain; Region: AAA_32; pfam13654
690850001822	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
690850001823	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
690850001824	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
690850001825	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
690850001826	dimer interface [polypeptide binding]; other site
690850001827	active site
690850001828	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
690850001829	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
690850001830	putative ligand binding site [chemical binding]; other site
690850001831	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
690850001832	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
690850001833	TM-ABC transporter signature motif; other site
690850001834	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
690850001835	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
690850001836	TM-ABC transporter signature motif; other site
690850001837	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
690850001838	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
690850001839	Walker A/P-loop; other site
690850001840	ATP binding site [chemical binding]; other site
690850001841	Q-loop/lid; other site
690850001842	ABC transporter signature motif; other site
690850001843	Walker B; other site
690850001844	D-loop; other site
690850001845	H-loop/switch region; other site
690850001846	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
690850001847	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
690850001848	Walker A/P-loop; other site
690850001849	ATP binding site [chemical binding]; other site
690850001850	Q-loop/lid; other site
690850001851	ABC transporter signature motif; other site
690850001852	Walker B; other site
690850001853	D-loop; other site
690850001854	H-loop/switch region; other site
690850001855	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
690850001856	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
690850001857	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
690850001858	active site pocket [active]
690850001859	putative dimer interface [polypeptide binding]; other site
690850001860	putative cataytic base [active]
690850001861	High-affinity nickel-transport protein; Region: NicO; cl00964
690850001862	Protein of unknown function (DUF1007); Region: DUF1007; cl01487
690850001863	flagellar assembly protein J; Reviewed; Region: PRK06041
690850001864	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
690850001865	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
690850001866	active site
690850001867	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
690850001868	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850001869	Protein of unknown function DUF45; Region: DUF45; pfam01863
690850001870	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
690850001871	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
690850001872	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
690850001873	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
690850001874	domain interfaces; other site
690850001875	active site
690850001876	shikimate kinase; Reviewed; Region: aroK; PRK00131
690850001877	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
690850001878	ADP binding site [chemical binding]; other site
690850001879	magnesium binding site [ion binding]; other site
690850001880	putative shikimate binding site; other site
690850001881	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850001882	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850001883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850001884	S-adenosylmethionine binding site [chemical binding]; other site
690850001885	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
690850001886	active site
690850001887	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850001888	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850001889	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
690850001890	Ca2+ binding site [ion binding]; other site
690850001891	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
690850001892	Ca2+ binding site [ion binding]; other site
690850001893	EF-hand domain pair; Region: EF_hand_6; pfam13833
690850001894	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
690850001895	Ca2+ binding site [ion binding]; other site
690850001896	EF-hand domain pair; Region: EF_hand_6; pfam13833
690850001897	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
690850001898	Ca2+ binding site [ion binding]; other site
690850001899	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
690850001900	Ca2+ binding site [ion binding]; other site
690850001901	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
690850001902	EF-hand domain pair; Region: EF_hand_5; pfam13499
690850001903	Ca2+ binding site [ion binding]; other site
690850001904	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
690850001905	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
690850001906	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
690850001907	heme-binding residues [chemical binding]; other site
690850001908	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
690850001909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850001910	dimer interface [polypeptide binding]; other site
690850001911	conserved gate region; other site
690850001912	putative PBP binding loops; other site
690850001913	ABC-ATPase subunit interface; other site
690850001914	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
690850001915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850001916	dimer interface [polypeptide binding]; other site
690850001917	conserved gate region; other site
690850001918	ABC-ATPase subunit interface; other site
690850001919	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
690850001920	Uncharacterized conserved protein [Function unknown]; Region: COG1284
690850001921	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
690850001922	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
690850001923	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
690850001924	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
690850001925	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
690850001926	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
690850001927	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
690850001928	Predicted transcriptional regulator [Transcription]; Region: COG2932
690850001929	sequence-specific DNA binding site [nucleotide binding]; other site
690850001930	salt bridge; other site
690850001931	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
690850001932	Catalytic site [active]
690850001933	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
690850001934	Integrase core domain; Region: rve; pfam00665
690850001935	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
690850001936	AAA domain; Region: AAA_22; pfam13401
690850001937	CENP-B N-terminal DNA-binding domain; Region: CENP-B_N; pfam04218
690850001938	DNA packaging tegument protein UL25; Provisional; Region: PHA03248
690850001939	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
690850001940	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
690850001941	Mor transcription activator family; Region: Mor; cl02360
690850001942	Staphylococcal nuclease homologues; Region: SNc; smart00318
690850001943	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
690850001944	Catalytic site; other site
690850001945	Peptidase M15; Region: Peptidase_M15_3; cl01194
690850001946	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
690850001947	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
690850001948	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
690850001949	Protein of unknown function (DUF935); Region: DUF935; pfam06074
690850001950	Mu-like prophage protein gp29 [Function unknown]; Region: COG4383
690850001951	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
690850001952	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
690850001953	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
690850001954	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
690850001955	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
690850001956	Protein of unknown function (DUF1320); Region: DUF1320; pfam07030
690850001957	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
690850001958	Domain of unknown function (DUF1834); Region: DUF1834; cl02087
690850001959	Protein of unknown function (DUF2635); Region: DUF2635; pfam10948
690850001960	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
690850001961	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
690850001962	Phage tail tube protein; Region: Tail_tube; pfam10618
690850001963	Mu-like prophage FluMu protein gp41 [Function unknown]; Region: COG4518
690850001964	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
690850001965	Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228
690850001966	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
690850001967	Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379
690850001968	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
690850001969	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
690850001970	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410
690850001971	Phage protein GP46; Region: GP46; pfam07409
690850001972	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
690850001973	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
690850001974	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
690850001975	classical (c) SDRs; Region: SDR_c; cd05233
690850001976	NAD(P) binding site [chemical binding]; other site
690850001977	active site
690850001978	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
690850001979	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
690850001980	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
690850001981	Peptidase M16C associated; Region: M16C_assoc; pfam08367
690850001982	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
690850001983	cytochrome c-550; Provisional; Region: psbV; cl17239
690850001984	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
690850001985	Transposase; Region: DEDD_Tnp_IS110; pfam01548
690850001986	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
690850001987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850001988	ATP binding site [chemical binding]; other site
690850001989	Mg2+ binding site [ion binding]; other site
690850001990	G-X-G motif; other site
690850001991	Response regulator receiver domain; Region: Response_reg; pfam00072
690850001992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850001993	active site
690850001994	phosphorylation site [posttranslational modification]
690850001995	intermolecular recognition site; other site
690850001996	dimerization interface [polypeptide binding]; other site
690850001997	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850001998	dimer interface [polypeptide binding]; other site
690850001999	phosphorylation site [posttranslational modification]
690850002000	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850002001	ATP binding site [chemical binding]; other site
690850002002	Mg2+ binding site [ion binding]; other site
690850002003	G-X-G motif; other site
690850002004	Response regulator receiver domain; Region: Response_reg; pfam00072
690850002005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850002006	intermolecular recognition site; other site
690850002007	active site
690850002008	dimerization interface [polypeptide binding]; other site
690850002009	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
690850002010	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
690850002011	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850002012	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
690850002013	Walker A motif; other site
690850002014	ATP binding site [chemical binding]; other site
690850002015	Walker B motif; other site
690850002016	arginine finger; other site
690850002017	Predicted permeases [General function prediction only]; Region: COG0730
690850002018	HAMP domain; Region: HAMP; pfam00672
690850002019	dimerization interface [polypeptide binding]; other site
690850002020	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850002021	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850002022	dimer interface [polypeptide binding]; other site
690850002023	putative CheW interface [polypeptide binding]; other site
690850002024	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
690850002025	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
690850002026	metal-binding site
690850002027	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
690850002028	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
690850002029	metal-binding site
690850002030	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850002031	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850002032	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850002033	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
690850002034	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
690850002035	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
690850002036	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850002037	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
690850002038	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
690850002039	DXD motif; other site
690850002040	Bacterial sugar transferase; Region: Bac_transf; pfam02397
690850002041	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
690850002042	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
690850002043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850002044	Walker A motif; other site
690850002045	ATP binding site [chemical binding]; other site
690850002046	Walker B motif; other site
690850002047	arginine finger; other site
690850002048	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
690850002049	Chain length determinant protein; Region: Wzz; cl15801
690850002050	Chain length determinant protein; Region: Wzz; cl15801
690850002051	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
690850002052	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
690850002053	SLBB domain; Region: SLBB; pfam10531
690850002054	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
690850002055	putative active site [active]
690850002056	putative metal binding site [ion binding]; other site
690850002057	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
690850002058	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
690850002059	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850002060	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850002061	active site
690850002062	phosphorylation site [posttranslational modification]
690850002063	intermolecular recognition site; other site
690850002064	dimerization interface [polypeptide binding]; other site
690850002065	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850002066	Walker A motif; other site
690850002067	ATP binding site [chemical binding]; other site
690850002068	Walker B motif; other site
690850002069	arginine finger; other site
690850002070	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
690850002071	core domain interface [polypeptide binding]; other site
690850002072	delta subunit interface [polypeptide binding]; other site
690850002073	epsilon subunit interface [polypeptide binding]; other site
690850002074	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
690850002075	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
690850002076	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
690850002077	Walker A motif; other site
690850002078	ATP binding site [chemical binding]; other site
690850002079	Walker B motif; other site
690850002080	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
690850002081	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
690850002082	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
690850002083	ATP synthase subunit C; Region: ATP-synt_C; cl00466
690850002084	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
690850002085	ATP synthase A chain; Region: ATP-synt_A; cl00413
690850002086	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
690850002087	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
690850002088	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
690850002089	gamma subunit interface [polypeptide binding]; other site
690850002090	epsilon subunit interface [polypeptide binding]; other site
690850002091	LBP interface [polypeptide binding]; other site
690850002092	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
690850002093	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
690850002094	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
690850002095	alpha subunit interaction interface [polypeptide binding]; other site
690850002096	Walker A motif; other site
690850002097	ATP binding site [chemical binding]; other site
690850002098	Walker B motif; other site
690850002099	inhibitor binding site; inhibition site
690850002100	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
690850002101	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
690850002102	Ligand Binding Site [chemical binding]; other site
690850002103	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
690850002104	Ligand Binding Site [chemical binding]; other site
690850002105	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
690850002106	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
690850002107	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
690850002108	HAMP domain; Region: HAMP; pfam00672
690850002109	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850002110	dimerization interface [polypeptide binding]; other site
690850002111	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850002112	dimer interface [polypeptide binding]; other site
690850002113	phosphorylation site [posttranslational modification]
690850002114	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850002115	ATP binding site [chemical binding]; other site
690850002116	Mg2+ binding site [ion binding]; other site
690850002117	G-X-G motif; other site
690850002118	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850002119	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850002120	active site
690850002121	phosphorylation site [posttranslational modification]
690850002122	intermolecular recognition site; other site
690850002123	dimerization interface [polypeptide binding]; other site
690850002124	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850002125	Walker A motif; other site
690850002126	ATP binding site [chemical binding]; other site
690850002127	Walker B motif; other site
690850002128	arginine finger; other site
690850002129	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850002130	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
690850002131	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
690850002132	Walker A/P-loop; other site
690850002133	ATP binding site [chemical binding]; other site
690850002134	Q-loop/lid; other site
690850002135	ABC transporter signature motif; other site
690850002136	Walker B; other site
690850002137	D-loop; other site
690850002138	H-loop/switch region; other site
690850002139	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
690850002140	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
690850002141	Probable Catalytic site; other site
690850002142	metal-binding site
690850002143	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
690850002144	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
690850002145	active site
690850002146	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850002147	S-adenosylmethionine binding site [chemical binding]; other site
690850002148	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
690850002149	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
690850002150	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
690850002151	active site
690850002152	catalytic residues [active]
690850002153	metal binding site [ion binding]; metal-binding site
690850002154	nitrogenase reductase; Reviewed; Region: nifH; PRK13235
690850002155	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
690850002156	Nucleotide-binding sites [chemical binding]; other site
690850002157	Walker A motif; other site
690850002158	Switch I region of nucleotide binding site; other site
690850002159	Fe4S4 binding sites [ion binding]; other site
690850002160	Switch II region of nucleotide binding site; other site
690850002161	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
690850002162	Nitrogen regulatory protein P-II; Region: P-II; smart00938
690850002163	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
690850002164	Nitrogen regulatory protein P-II; Region: P-II; smart00938
690850002165	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
690850002166	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
690850002167	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
690850002168	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
690850002169	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
690850002170	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
690850002171	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
690850002172	dimer interface [polypeptide binding]; other site
690850002173	[2Fe-2S] cluster binding site [ion binding]; other site
690850002174	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
690850002175	putative catalytic site [active]
690850002176	putative metal binding site [ion binding]; other site
690850002177	putative phosphate binding site [ion binding]; other site
690850002178	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
690850002179	active site
690850002180	Right handed beta helix region; Region: Beta_helix; pfam13229
690850002181	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
690850002182	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
690850002183	Metal-binding active site; metal-binding site
690850002184	PAS domain; Region: PAS_9; pfam13426
690850002185	GAF domain; Region: GAF; pfam01590
690850002186	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850002187	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850002188	putative active site [active]
690850002189	heme pocket [chemical binding]; other site
690850002190	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850002191	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850002192	putative active site [active]
690850002193	heme pocket [chemical binding]; other site
690850002194	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850002195	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850002196	putative active site [active]
690850002197	heme pocket [chemical binding]; other site
690850002198	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850002199	dimer interface [polypeptide binding]; other site
690850002200	phosphorylation site [posttranslational modification]
690850002201	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850002202	ATP binding site [chemical binding]; other site
690850002203	Mg2+ binding site [ion binding]; other site
690850002204	G-X-G motif; other site
690850002205	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850002206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850002207	active site
690850002208	phosphorylation site [posttranslational modification]
690850002209	intermolecular recognition site; other site
690850002210	dimerization interface [polypeptide binding]; other site
690850002211	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
690850002212	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
690850002213	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
690850002214	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
690850002215	DNA binding residues [nucleotide binding]
690850002216	dimerization interface [polypeptide binding]; other site
690850002217	YCII-related domain; Region: YCII; cl00999
690850002218	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
690850002219	tetramerization interface [polypeptide binding]; other site
690850002220	active site
690850002221	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
690850002222	active site
690850002223	dimer interfaces [polypeptide binding]; other site
690850002224	catalytic residues [active]
690850002225	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
690850002226	CoenzymeA binding site [chemical binding]; other site
690850002227	subunit interaction site [polypeptide binding]; other site
690850002228	PHB binding site; other site
690850002229	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850002230	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850002231	active site
690850002232	phosphorylation site [posttranslational modification]
690850002233	intermolecular recognition site; other site
690850002234	dimerization interface [polypeptide binding]; other site
690850002235	4Fe-4S binding domain; Region: Fer4_5; pfam12801
690850002236	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
690850002237	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
690850002238	PAS domain; Region: PAS_9; pfam13426
690850002239	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850002240	putative active site [active]
690850002241	heme pocket [chemical binding]; other site
690850002242	PAS domain S-box; Region: sensory_box; TIGR00229
690850002243	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850002244	putative active site [active]
690850002245	heme pocket [chemical binding]; other site
690850002246	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850002247	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850002248	metal binding site [ion binding]; metal-binding site
690850002249	active site
690850002250	I-site; other site
690850002251	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
690850002252	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
690850002253	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850002254	dimerization interface [polypeptide binding]; other site
690850002255	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850002256	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850002257	dimer interface [polypeptide binding]; other site
690850002258	putative CheW interface [polypeptide binding]; other site
690850002259	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
690850002260	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
690850002261	DRTGG domain; Region: DRTGG; pfam07085
690850002262	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
690850002263	CoA binding domain; Region: CoA_binding_2; pfam13380
690850002264	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
690850002265	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
690850002266	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
690850002267	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
690850002268	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
690850002269	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
690850002270	active site
690850002271	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
690850002272	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
690850002273	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
690850002274	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
690850002275	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
690850002276	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
690850002277	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
690850002278	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
690850002279	active site
690850002280	dimer interface [polypeptide binding]; other site
690850002281	motif 1; other site
690850002282	motif 2; other site
690850002283	motif 3; other site
690850002284	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
690850002285	anticodon binding site; other site
690850002286	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
690850002287	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
690850002288	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
690850002289	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
690850002290	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
690850002291	23S rRNA binding site [nucleotide binding]; other site
690850002292	L21 binding site [polypeptide binding]; other site
690850002293	L13 binding site [polypeptide binding]; other site
690850002294	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
690850002295	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
690850002296	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
690850002297	dimer interface [polypeptide binding]; other site
690850002298	motif 1; other site
690850002299	active site
690850002300	motif 2; other site
690850002301	motif 3; other site
690850002302	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
690850002303	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
690850002304	putative tRNA-binding site [nucleotide binding]; other site
690850002305	B3/4 domain; Region: B3_4; pfam03483
690850002306	tRNA synthetase B5 domain; Region: B5; smart00874
690850002307	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
690850002308	dimer interface [polypeptide binding]; other site
690850002309	motif 1; other site
690850002310	motif 3; other site
690850002311	motif 2; other site
690850002312	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
690850002313	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
690850002314	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
690850002315	dimer interface [polypeptide binding]; other site
690850002316	active site
690850002317	CoA binding pocket [chemical binding]; other site
690850002318	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
690850002319	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
690850002320	DNA binding residues [nucleotide binding]
690850002321	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
690850002322	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
690850002323	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
690850002324	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
690850002325	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
690850002326	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
690850002327	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
690850002328	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850002329	dimer interface [polypeptide binding]; other site
690850002330	conserved gate region; other site
690850002331	putative PBP binding loops; other site
690850002332	ABC-ATPase subunit interface; other site
690850002333	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
690850002334	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
690850002335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850002336	dimer interface [polypeptide binding]; other site
690850002337	conserved gate region; other site
690850002338	putative PBP binding loops; other site
690850002339	ABC-ATPase subunit interface; other site
690850002340	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
690850002341	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
690850002342	Walker A/P-loop; other site
690850002343	ATP binding site [chemical binding]; other site
690850002344	Q-loop/lid; other site
690850002345	ABC transporter signature motif; other site
690850002346	Walker B; other site
690850002347	D-loop; other site
690850002348	H-loop/switch region; other site
690850002349	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
690850002350	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
690850002351	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
690850002352	Walker A/P-loop; other site
690850002353	ATP binding site [chemical binding]; other site
690850002354	Q-loop/lid; other site
690850002355	ABC transporter signature motif; other site
690850002356	Walker B; other site
690850002357	D-loop; other site
690850002358	H-loop/switch region; other site
690850002359	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
690850002360	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
690850002361	Coenzyme A binding pocket [chemical binding]; other site
690850002362	Dienelactone hydrolase family; Region: DLH; pfam01738
690850002363	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
690850002364	Uncharacterized conserved protein [Function unknown]; Region: COG1284
690850002365	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
690850002366	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
690850002367	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
690850002368	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
690850002369	CoA binding domain; Region: CoA_binding; pfam02629
690850002370	ATP synthase subunit C; Region: ATP-synt_C; cl00466
690850002371	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
690850002372	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
690850002373	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
690850002374	AAA domain; Region: AAA_32; pfam13654
690850002375	H+ Antiporter protein; Region: 2A0121; TIGR00900
690850002376	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
690850002377	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
690850002378	Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947
690850002379	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
690850002380	active site
690850002381	catalytic residues [active]
690850002382	metal binding site [ion binding]; metal-binding site
690850002383	Cache domain; Region: Cache_1; pfam02743
690850002384	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
690850002385	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
690850002386	Sporulation related domain; Region: SPOR; pfam05036
690850002387	CheB methylesterase; Region: CheB_methylest; pfam01339
690850002388	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
690850002389	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
690850002390	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
690850002391	PAS domain; Region: PAS_10; pfam13596
690850002392	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850002393	putative active site [active]
690850002394	heme pocket [chemical binding]; other site
690850002395	PAS fold; Region: PAS; pfam00989
690850002396	PAS domain S-box; Region: sensory_box; TIGR00229
690850002397	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850002398	putative active site [active]
690850002399	heme pocket [chemical binding]; other site
690850002400	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850002401	PAS fold; Region: PAS_3; pfam08447
690850002402	putative active site [active]
690850002403	heme pocket [chemical binding]; other site
690850002404	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
690850002405	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
690850002406	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850002407	dimer interface [polypeptide binding]; other site
690850002408	phosphorylation site [posttranslational modification]
690850002409	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850002410	ATP binding site [chemical binding]; other site
690850002411	Mg2+ binding site [ion binding]; other site
690850002412	G-X-G motif; other site
690850002413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850002414	Response regulator receiver domain; Region: Response_reg; pfam00072
690850002415	active site
690850002416	phosphorylation site [posttranslational modification]
690850002417	intermolecular recognition site; other site
690850002418	dimerization interface [polypeptide binding]; other site
690850002419	Response regulator receiver domain; Region: Response_reg; pfam00072
690850002420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850002421	active site
690850002422	phosphorylation site [posttranslational modification]
690850002423	intermolecular recognition site; other site
690850002424	dimerization interface [polypeptide binding]; other site
690850002425	Response regulator receiver domain; Region: Response_reg; pfam00072
690850002426	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850002427	active site
690850002428	phosphorylation site [posttranslational modification]
690850002429	intermolecular recognition site; other site
690850002430	dimerization interface [polypeptide binding]; other site
690850002431	GTP-binding protein YchF; Reviewed; Region: PRK09601
690850002432	YchF GTPase; Region: YchF; cd01900
690850002433	G1 box; other site
690850002434	GTP/Mg2+ binding site [chemical binding]; other site
690850002435	Switch I region; other site
690850002436	G2 box; other site
690850002437	Switch II region; other site
690850002438	G3 box; other site
690850002439	G4 box; other site
690850002440	G5 box; other site
690850002441	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
690850002442	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
690850002443	IHF - DNA interface [nucleotide binding]; other site
690850002444	IHF dimer interface [polypeptide binding]; other site
690850002445	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
690850002446	HIT family signature motif; other site
690850002447	catalytic residue [active]
690850002448	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850002449	Radical SAM superfamily; Region: Radical_SAM; pfam04055
690850002450	FeS/SAM binding site; other site
690850002451	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
690850002452	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
690850002453	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
690850002454	dihydroorotase; Validated; Region: pyrC; PRK09357
690850002455	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
690850002456	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
690850002457	active site
690850002458	Sulfatase; Region: Sulfatase; cl17466
690850002459	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830
690850002460	6-phosphofructokinase; Region: PLN02884
690850002461	active site
690850002462	ADP/pyrophosphate binding site [chemical binding]; other site
690850002463	dimerization interface [polypeptide binding]; other site
690850002464	allosteric effector site; other site
690850002465	fructose-1,6-bisphosphate binding site; other site
690850002466	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
690850002467	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
690850002468	putative dimer interface [polypeptide binding]; other site
690850002469	heat shock protein HtpX; Provisional; Region: PRK03982
690850002470	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
690850002471	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
690850002472	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
690850002473	protein binding site [polypeptide binding]; other site
690850002474	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
690850002475	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
690850002476	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
690850002477	active site
690850002478	metal binding site [ion binding]; metal-binding site
690850002479	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
690850002480	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
690850002481	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
690850002482	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
690850002483	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
690850002484	NADP binding site [chemical binding]; other site
690850002485	active site
690850002486	putative substrate binding site [chemical binding]; other site
690850002487	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
690850002488	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
690850002489	NADP-binding site; other site
690850002490	homotetramer interface [polypeptide binding]; other site
690850002491	substrate binding site [chemical binding]; other site
690850002492	homodimer interface [polypeptide binding]; other site
690850002493	active site
690850002494	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
690850002495	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
690850002496	putative active site [active]
690850002497	catalytic site [active]
690850002498	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
690850002499	putative active site [active]
690850002500	catalytic site [active]
690850002501	Uncharacterized conserved protein [Function unknown]; Region: COG0398
690850002502	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
690850002503	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
690850002504	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
690850002505	Walker A/P-loop; other site
690850002506	ATP binding site [chemical binding]; other site
690850002507	Q-loop/lid; other site
690850002508	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
690850002509	ABC transporter signature motif; other site
690850002510	Walker B; other site
690850002511	D-loop; other site
690850002512	H-loop/switch region; other site
690850002513	PAS domain; Region: PAS_9; pfam13426
690850002514	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850002515	putative active site [active]
690850002516	heme pocket [chemical binding]; other site
690850002517	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850002518	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850002519	dimer interface [polypeptide binding]; other site
690850002520	phosphorylation site [posttranslational modification]
690850002521	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850002522	ATP binding site [chemical binding]; other site
690850002523	Mg2+ binding site [ion binding]; other site
690850002524	G-X-G motif; other site
690850002525	Response regulator receiver domain; Region: Response_reg; pfam00072
690850002526	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850002527	active site
690850002528	phosphorylation site [posttranslational modification]
690850002529	intermolecular recognition site; other site
690850002530	dimerization interface [polypeptide binding]; other site
690850002531	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
690850002532	dimerization interface [polypeptide binding]; other site
690850002533	putative DNA binding site [nucleotide binding]; other site
690850002534	putative Zn2+ binding site [ion binding]; other site
690850002535	PAS domain; Region: PAS_9; pfam13426
690850002536	PAS domain S-box; Region: sensory_box; TIGR00229
690850002537	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850002538	putative active site [active]
690850002539	heme pocket [chemical binding]; other site
690850002540	PAS domain; Region: PAS; smart00091
690850002541	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850002542	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850002543	putative active site [active]
690850002544	heme pocket [chemical binding]; other site
690850002545	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850002546	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850002547	dimer interface [polypeptide binding]; other site
690850002548	phosphorylation site [posttranslational modification]
690850002549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850002550	ATP binding site [chemical binding]; other site
690850002551	Mg2+ binding site [ion binding]; other site
690850002552	G-X-G motif; other site
690850002553	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850002554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850002555	active site
690850002556	phosphorylation site [posttranslational modification]
690850002557	intermolecular recognition site; other site
690850002558	dimerization interface [polypeptide binding]; other site
690850002559	FeoA domain; Region: FeoA; pfam04023
690850002560	FeoA domain; Region: FeoA; pfam04023
690850002561	ferric uptake regulator; Provisional; Region: fur; PRK09462
690850002562	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
690850002563	metal binding site 2 [ion binding]; metal-binding site
690850002564	putative DNA binding helix; other site
690850002565	metal binding site 1 [ion binding]; metal-binding site
690850002566	dimer interface [polypeptide binding]; other site
690850002567	structural Zn2+ binding site [ion binding]; other site
690850002568	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
690850002569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850002570	active site
690850002571	phosphorylation site [posttranslational modification]
690850002572	intermolecular recognition site; other site
690850002573	dimerization interface [polypeptide binding]; other site
690850002574	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
690850002575	DNA binding site [nucleotide binding]
690850002576	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850002577	dimerization interface [polypeptide binding]; other site
690850002578	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850002579	PAS domain; Region: PAS; smart00091
690850002580	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850002581	dimer interface [polypeptide binding]; other site
690850002582	phosphorylation site [posttranslational modification]
690850002583	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850002584	ATP binding site [chemical binding]; other site
690850002585	Mg2+ binding site [ion binding]; other site
690850002586	G-X-G motif; other site
690850002587	phosphate transporter ATP-binding protein; Provisional; Region: PRK14242
690850002588	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
690850002589	Walker A/P-loop; other site
690850002590	ATP binding site [chemical binding]; other site
690850002591	Q-loop/lid; other site
690850002592	ABC transporter signature motif; other site
690850002593	Walker B; other site
690850002594	D-loop; other site
690850002595	H-loop/switch region; other site
690850002596	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
690850002597	PhoU domain; Region: PhoU; pfam01895
690850002598	PhoU domain; Region: PhoU; pfam01895
690850002599	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
690850002600	active site
690850002601	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
690850002602	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850002603	dimerization interface [polypeptide binding]; other site
690850002604	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
690850002605	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
690850002606	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
690850002607	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
690850002608	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
690850002609	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
690850002610	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
690850002611	Ligand Binding Site [chemical binding]; other site
690850002612	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
690850002613	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
690850002614	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850002615	Coenzyme A binding pocket [chemical binding]; other site
690850002616	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
690850002617	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
690850002618	Walker A motif; other site
690850002619	ATP binding site [chemical binding]; other site
690850002620	Walker B motif; other site
690850002621	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
690850002622	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
690850002623	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
690850002624	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
690850002625	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
690850002626	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
690850002627	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
690850002628	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
690850002629	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
690850002630	Walker A motif; other site
690850002631	ATP binding site [chemical binding]; other site
690850002632	Walker B motif; other site
690850002633	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
690850002634	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
690850002635	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
690850002636	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
690850002637	Dynein light intermediate chain (DLIC); Region: DLIC; pfam05783
690850002638	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
690850002639	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
690850002640	endonuclease IV; Provisional; Region: PRK01060
690850002641	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
690850002642	AP (apurinic/apyrimidinic) site pocket; other site
690850002643	DNA interaction; other site
690850002644	Metal-binding active site; metal-binding site
690850002645	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
690850002646	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
690850002647	Ca2+ binding site [ion binding]; other site
690850002648	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
690850002649	Ca2+ binding site [ion binding]; other site
690850002650	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
690850002651	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850002652	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850002653	metal binding site [ion binding]; metal-binding site
690850002654	active site
690850002655	I-site; other site
690850002656	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850002657	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850002658	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850002659	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
690850002660	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
690850002661	molybdopterin cofactor binding site; other site
690850002662	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
690850002663	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
690850002664	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
690850002665	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
690850002666	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
690850002667	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
690850002668	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850002669	FeS/SAM binding site; other site
690850002670	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
690850002671	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
690850002672	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
690850002673	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
690850002674	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
690850002675	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
690850002676	Transposase; Region: DEDD_Tnp_IS110; pfam01548
690850002677	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
690850002678	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
690850002679	EF-hand domain pair; Region: EF_hand_5; pfam13499
690850002680	Ca2+ binding site [ion binding]; other site
690850002681	malonic semialdehyde reductase; Provisional; Region: PRK10538
690850002682	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
690850002683	putative NAD(P) binding site [chemical binding]; other site
690850002684	homotetramer interface [polypeptide binding]; other site
690850002685	homodimer interface [polypeptide binding]; other site
690850002686	active site
690850002687	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
690850002688	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
690850002689	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
690850002690	protein binding site [polypeptide binding]; other site
690850002691	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
690850002692	protein binding site [polypeptide binding]; other site
690850002693	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
690850002694	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
690850002695	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850002696	Walker A/P-loop; other site
690850002697	ATP binding site [chemical binding]; other site
690850002698	Q-loop/lid; other site
690850002699	ABC transporter signature motif; other site
690850002700	Walker B; other site
690850002701	D-loop; other site
690850002702	H-loop/switch region; other site
690850002703	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850002704	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850002705	dimer interface [polypeptide binding]; other site
690850002706	phosphorylation site [posttranslational modification]
690850002707	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850002708	ATP binding site [chemical binding]; other site
690850002709	Mg2+ binding site [ion binding]; other site
690850002710	G-X-G motif; other site
690850002711	Response regulator receiver domain; Region: Response_reg; pfam00072
690850002712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850002713	active site
690850002714	phosphorylation site [posttranslational modification]
690850002715	intermolecular recognition site; other site
690850002716	dimerization interface [polypeptide binding]; other site
690850002717	Predicted membrane protein [Function unknown]; Region: COG3671
690850002718	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
690850002719	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
690850002720	Interdomain contacts; other site
690850002721	Cytokine receptor motif; other site
690850002722	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
690850002723	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
690850002724	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
690850002725	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
690850002726	motif II; other site
690850002727	4-alpha-glucanotransferase; Provisional; Region: PRK14508
690850002728	PRC-barrel domain; Region: PRC; pfam05239
690850002729	PRC-barrel domain; Region: PRC; pfam05239
690850002730	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850002731	dimerization interface [polypeptide binding]; other site
690850002732	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850002733	dimer interface [polypeptide binding]; other site
690850002734	phosphorylation site [posttranslational modification]
690850002735	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
690850002736	Mg2+ binding site [ion binding]; other site
690850002737	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850002738	Response regulator receiver domain; Region: Response_reg; pfam00072
690850002739	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850002740	active site
690850002741	phosphorylation site [posttranslational modification]
690850002742	intermolecular recognition site; other site
690850002743	dimerization interface [polypeptide binding]; other site
690850002744	AAA domain; Region: AAA_26; pfam13500
690850002745	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
690850002746	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
690850002747	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
690850002748	inhibitor-cofactor binding pocket; inhibition site
690850002749	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850002750	catalytic residue [active]
690850002751	heat shock protein 90; Provisional; Region: PRK05218
690850002752	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850002753	ATP binding site [chemical binding]; other site
690850002754	Mg2+ binding site [ion binding]; other site
690850002755	G-X-G motif; other site
690850002756	Transcriptional regulator [Transcription]; Region: LysR; COG0583
690850002757	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
690850002758	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
690850002759	dimerization interface [polypeptide binding]; other site
690850002760	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
690850002761	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
690850002762	Uncharacterized conserved protein [Function unknown]; Region: COG2006
690850002763	4Fe-4S binding domain; Region: Fer4_6; pfam12837
690850002764	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
690850002765	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850002766	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850002767	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
690850002768	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850002769	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
690850002770	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
690850002771	WHG domain; Region: WHG; pfam13305
690850002772	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
690850002773	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
690850002774	Hemerythrin-like domain; Region: Hr-like; cd12108
690850002775	Fe binding site [ion binding]; other site
690850002776	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
690850002777	CAAX protease self-immunity; Region: Abi; cl00558
690850002778	MgtC family; Region: MgtC; pfam02308
690850002779	peroxiredoxin; Region: AhpC; TIGR03137
690850002780	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
690850002781	dimer interface [polypeptide binding]; other site
690850002782	decamer (pentamer of dimers) interface [polypeptide binding]; other site
690850002783	catalytic triad [active]
690850002784	peroxidatic and resolving cysteines [active]
690850002785	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
690850002786	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
690850002787	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
690850002788	FeoA domain; Region: FeoA; pfam04023
690850002789	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
690850002790	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
690850002791	G1 box; other site
690850002792	GTP/Mg2+ binding site [chemical binding]; other site
690850002793	Switch I region; other site
690850002794	G2 box; other site
690850002795	G3 box; other site
690850002796	Switch II region; other site
690850002797	G4 box; other site
690850002798	G5 box; other site
690850002799	Nucleoside recognition; Region: Gate; pfam07670
690850002800	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
690850002801	Nucleoside recognition; Region: Gate; pfam07670
690850002802	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
690850002803	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
690850002804	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
690850002805	PAS fold; Region: PAS_4; pfam08448
690850002806	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850002807	putative active site [active]
690850002808	heme pocket [chemical binding]; other site
690850002809	Sensory domain found in PocR; Region: PocR; pfam10114
690850002810	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
690850002811	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
690850002812	Histidine kinase; Region: HisKA_2; pfam07568
690850002813	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850002814	ATP binding site [chemical binding]; other site
690850002815	Mg2+ binding site [ion binding]; other site
690850002816	G-X-G motif; other site
690850002817	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
690850002818	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
690850002819	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
690850002820	transmembrane helices; other site
690850002821	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850002822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850002823	active site
690850002824	phosphorylation site [posttranslational modification]
690850002825	intermolecular recognition site; other site
690850002826	dimerization interface [polypeptide binding]; other site
690850002827	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850002828	Walker A motif; other site
690850002829	ATP binding site [chemical binding]; other site
690850002830	Walker B motif; other site
690850002831	arginine finger; other site
690850002832	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850002833	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
690850002834	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
690850002835	substrate binding pocket [chemical binding]; other site
690850002836	membrane-bound complex binding site; other site
690850002837	hinge residues; other site
690850002838	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
690850002839	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850002840	ATP binding site [chemical binding]; other site
690850002841	Mg2+ binding site [ion binding]; other site
690850002842	G-X-G motif; other site
690850002843	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
690850002844	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
690850002845	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850002846	Walker A motif; other site
690850002847	ATP binding site [chemical binding]; other site
690850002848	Walker B motif; other site
690850002849	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
690850002850	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
690850002851	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850002852	Zn2+ binding site [ion binding]; other site
690850002853	Mg2+ binding site [ion binding]; other site
690850002854	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
690850002855	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
690850002856	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
690850002857	FOG: CBS domain [General function prediction only]; Region: COG0517
690850002858	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850002859	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850002860	metal binding site [ion binding]; metal-binding site
690850002861	active site
690850002862	I-site; other site
690850002863	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
690850002864	PIN domain; Region: PIN_Smg5-Smg6-like; cd09880
690850002865	putative active site [active]
690850002866	PhoH-like protein; Region: PhoH; cl17668
690850002867	Methyltransferase domain; Region: Methyltransf_23; pfam13489
690850002868	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850002869	S-adenosylmethionine binding site [chemical binding]; other site
690850002870	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850002871	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850002872	active site
690850002873	phosphorylation site [posttranslational modification]
690850002874	intermolecular recognition site; other site
690850002875	dimerization interface [polypeptide binding]; other site
690850002876	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850002877	Walker A motif; other site
690850002878	ATP binding site [chemical binding]; other site
690850002879	Walker B motif; other site
690850002880	arginine finger; other site
690850002881	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850002882	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850002883	dimer interface [polypeptide binding]; other site
690850002884	phosphorylation site [posttranslational modification]
690850002885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850002886	ATP binding site [chemical binding]; other site
690850002887	Mg2+ binding site [ion binding]; other site
690850002888	G-X-G motif; other site
690850002889	aspartate aminotransferase; Provisional; Region: PRK05764
690850002890	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
690850002891	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850002892	homodimer interface [polypeptide binding]; other site
690850002893	catalytic residue [active]
690850002894	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
690850002895	Mechanosensitive ion channel; Region: MS_channel; pfam00924
690850002896	Cache domain; Region: Cache_1; pfam02743
690850002897	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850002898	dimerization interface [polypeptide binding]; other site
690850002899	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850002900	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850002901	dimer interface [polypeptide binding]; other site
690850002902	putative CheW interface [polypeptide binding]; other site
690850002903	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
690850002904	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
690850002905	active site
690850002906	motif I; other site
690850002907	motif II; other site
690850002908	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
690850002909	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
690850002910	glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377
690850002911	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
690850002912	Cysteine-rich domain; Region: CCG; pfam02754
690850002913	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
690850002914	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850002915	dimer interface [polypeptide binding]; other site
690850002916	conserved gate region; other site
690850002917	putative PBP binding loops; other site
690850002918	ABC-ATPase subunit interface; other site
690850002919	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850002920	dimer interface [polypeptide binding]; other site
690850002921	conserved gate region; other site
690850002922	putative PBP binding loops; other site
690850002923	ABC-ATPase subunit interface; other site
690850002924	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
690850002925	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
690850002926	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
690850002927	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850002928	Walker A/P-loop; other site
690850002929	ATP binding site [chemical binding]; other site
690850002930	Q-loop/lid; other site
690850002931	ABC transporter signature motif; other site
690850002932	Walker B; other site
690850002933	D-loop; other site
690850002934	H-loop/switch region; other site
690850002935	TOBE domain; Region: TOBE_2; pfam08402
690850002936	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
690850002937	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
690850002938	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
690850002939	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
690850002940	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
690850002941	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
690850002942	catalytic residue [active]
690850002943	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
690850002944	Serine hydrolase (FSH1); Region: FSH1; pfam03959
690850002945	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
690850002946	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850002947	S-adenosylmethionine binding site [chemical binding]; other site
690850002948	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
690850002949	thiamine phosphate binding site [chemical binding]; other site
690850002950	active site
690850002951	pyrophosphate binding site [ion binding]; other site
690850002952	ribulose-1,5-biphosphate synthetase; Provisional; Region: PRK04176
690850002953	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
690850002954	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
690850002955	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
690850002956	non-specific DNA binding site [nucleotide binding]; other site
690850002957	salt bridge; other site
690850002958	sequence-specific DNA binding site [nucleotide binding]; other site
690850002959	Cupin domain; Region: Cupin_2; pfam07883
690850002960	AMP-binding domain protein; Validated; Region: PRK08315
690850002961	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
690850002962	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
690850002963	acyl-activating enzyme (AAE) consensus motif; other site
690850002964	putative AMP binding site [chemical binding]; other site
690850002965	putative active site [active]
690850002966	putative CoA binding site [chemical binding]; other site
690850002967	RDD family; Region: RDD; pfam06271
690850002968	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
690850002969	nucleophile elbow; other site
690850002970	hybrid cluster protein; Provisional; Region: PRK05290
690850002971	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850002972	ACS interaction site; other site
690850002973	CODH interaction site; other site
690850002974	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
690850002975	hybrid metal cluster; other site
690850002976	hybrid cluster protein; Provisional; Region: PRK05290
690850002977	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850002978	ACS interaction site; other site
690850002979	CODH interaction site; other site
690850002980	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
690850002981	hybrid metal cluster; other site
690850002982	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
690850002983	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
690850002984	dimer interface [polypeptide binding]; other site
690850002985	putative functional site; other site
690850002986	putative MPT binding site; other site
690850002987	maltose O-acetyltransferase; Provisional; Region: PRK10092
690850002988	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
690850002989	active site
690850002990	substrate binding site [chemical binding]; other site
690850002991	trimer interface [polypeptide binding]; other site
690850002992	CoA binding site [chemical binding]; other site
690850002993	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
690850002994	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
690850002995	putative RNA binding site [nucleotide binding]; other site
690850002996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850002997	S-adenosylmethionine binding site [chemical binding]; other site
690850002998	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
690850002999	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
690850003000	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
690850003001	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
690850003002	active site
690850003003	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
690850003004	AMMECR1; Region: AMMECR1; pfam01871
690850003005	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
690850003006	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
690850003007	active site
690850003008	substrate binding site [chemical binding]; other site
690850003009	cosubstrate binding site; other site
690850003010	catalytic site [active]
690850003011	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
690850003012	active site
690850003013	SAM binding site [chemical binding]; other site
690850003014	homodimer interface [polypeptide binding]; other site
690850003015	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
690850003016	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
690850003017	active site
690850003018	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
690850003019	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
690850003020	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
690850003021	NAD binding site [chemical binding]; other site
690850003022	substrate binding site [chemical binding]; other site
690850003023	homodimer interface [polypeptide binding]; other site
690850003024	active site
690850003025	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
690850003026	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
690850003027	substrate binding site; other site
690850003028	tetramer interface; other site
690850003029	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
690850003030	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
690850003031	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
690850003032	inhibitor-cofactor binding pocket; inhibition site
690850003033	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850003034	catalytic residue [active]
690850003035	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
690850003036	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
690850003037	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
690850003038	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
690850003039	active site
690850003040	Methyltransferase domain; Region: Methyltransf_11; pfam08241
690850003041	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
690850003042	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
690850003043	Walker A/P-loop; other site
690850003044	ATP binding site [chemical binding]; other site
690850003045	Q-loop/lid; other site
690850003046	ABC transporter signature motif; other site
690850003047	Walker B; other site
690850003048	D-loop; other site
690850003049	H-loop/switch region; other site
690850003050	Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754
690850003051	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850003052	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850003053	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
690850003054	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
690850003055	Probable Catalytic site; other site
690850003056	metal-binding site
690850003057	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
690850003058	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
690850003059	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
690850003060	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
690850003061	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850003062	S-adenosylmethionine binding site [chemical binding]; other site
690850003063	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
690850003064	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
690850003065	Walker A/P-loop; other site
690850003066	ATP binding site [chemical binding]; other site
690850003067	Q-loop/lid; other site
690850003068	ABC transporter signature motif; other site
690850003069	Walker B; other site
690850003070	D-loop; other site
690850003071	H-loop/switch region; other site
690850003072	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
690850003073	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
690850003074	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
690850003075	Methyltransferase domain; Region: Methyltransf_23; pfam13489
690850003076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850003077	S-adenosylmethionine binding site [chemical binding]; other site
690850003078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
690850003079	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850003080	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850003081	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
690850003082	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850003083	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
690850003084	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
690850003085	Catalytic site [active]
690850003086	GTP-binding protein LepA; Provisional; Region: PRK05433
690850003087	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
690850003088	G1 box; other site
690850003089	putative GEF interaction site [polypeptide binding]; other site
690850003090	GTP/Mg2+ binding site [chemical binding]; other site
690850003091	Switch I region; other site
690850003092	G2 box; other site
690850003093	G3 box; other site
690850003094	Switch II region; other site
690850003095	G4 box; other site
690850003096	G5 box; other site
690850003097	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
690850003098	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
690850003099	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
690850003100	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
690850003101	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
690850003102	nickel binding site [ion binding]; other site
690850003103	MASE1; Region: MASE1; pfam05231
690850003104	PAS domain S-box; Region: sensory_box; TIGR00229
690850003105	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850003106	putative active site [active]
690850003107	heme pocket [chemical binding]; other site
690850003108	PAS domain S-box; Region: sensory_box; TIGR00229
690850003109	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850003110	putative active site [active]
690850003111	heme pocket [chemical binding]; other site
690850003112	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
690850003113	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
690850003114	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850003115	dimer interface [polypeptide binding]; other site
690850003116	phosphorylation site [posttranslational modification]
690850003117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850003118	ATP binding site [chemical binding]; other site
690850003119	Mg2+ binding site [ion binding]; other site
690850003120	G-X-G motif; other site
690850003121	Response regulator receiver domain; Region: Response_reg; pfam00072
690850003122	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850003123	active site
690850003124	phosphorylation site [posttranslational modification]
690850003125	intermolecular recognition site; other site
690850003126	dimerization interface [polypeptide binding]; other site
690850003127	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
690850003128	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
690850003129	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
690850003130	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
690850003131	Alkaline phosphatase homologues; Region: alkPPc; smart00098
690850003132	active site
690850003133	dimer interface [polypeptide binding]; other site
690850003134	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
690850003135	YibE/F-like protein; Region: YibE_F; pfam07907
690850003136	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
690850003137	active site
690850003138	Cytochrome c552; Region: Cytochrom_C552; pfam02335
690850003139	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
690850003140	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
690850003141	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
690850003142	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
690850003143	4Fe-4S binding domain; Region: Fer4; cl02805
690850003144	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
690850003145	TRL-like protein family; Region: TRL; pfam13146
690850003146	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
690850003147	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
690850003148	amphi-Trp domain; Region: amphi-Trp; TIGR04354
690850003149	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
690850003150	PhoU domain; Region: PhoU; pfam01895
690850003151	PhoU domain; Region: PhoU; pfam01895
690850003152	Ecdysteroid kinase; Region: EcKinase; cl17738
690850003153	ATP-grasp enzyme, GAK system; Region: grasp_GAK; TIGR04356
690850003154	ATP-grasp domain; Region: ATP-grasp_4; cl17255
690850003155	HprK-related kinase B; Region: HprK_rel_B; TIGR04355
690850003156	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
690850003157	active site
690850003158	metal-binding site [ion binding]
690850003159	nucleotide-binding site [chemical binding]; other site
690850003160	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
690850003161	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
690850003162	phosphate binding site [ion binding]; other site
690850003163	putative substrate binding pocket [chemical binding]; other site
690850003164	dimer interface [polypeptide binding]; other site
690850003165	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
690850003166	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
690850003167	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
690850003168	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
690850003169	ABC-ATPase subunit  interface; other site
690850003170	dimer interface [polypeptide binding]; other site
690850003171	putative PBP binding regions; other site
690850003172	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
690850003173	cobalamin synthase; Reviewed; Region: cobS; PRK00235
690850003174	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
690850003175	Uncharacterized conserved protein [Function unknown]; Region: COG3334
690850003176	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
690850003177	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
690850003178	dimerization interface 3.5A [polypeptide binding]; other site
690850003179	active site
690850003180	pantoate--beta-alanine ligase; Region: panC; TIGR00018
690850003181	Pantoate-beta-alanine ligase; Region: PanC; cd00560
690850003182	active site
690850003183	ATP-binding site [chemical binding]; other site
690850003184	pantoate-binding site; other site
690850003185	HXXH motif; other site
690850003186	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
690850003187	Domain of unknown function (DUF1992); Region: DUF1992; cl08096
690850003188	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
690850003189	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
690850003190	putative ribose interaction site [chemical binding]; other site
690850003191	putative ADP binding site [chemical binding]; other site
690850003192	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
690850003193	ParB-like nuclease domain; Region: ParBc; pfam02195
690850003194	KorB domain; Region: KorB; pfam08535
690850003195	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
690850003196	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
690850003197	P-loop; other site
690850003198	Magnesium ion binding site [ion binding]; other site
690850003199	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
690850003200	Magnesium ion binding site [ion binding]; other site
690850003201	XXXCH domain; Region: XXXCH_domain; TIGR04358
690850003202	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
690850003203	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
690850003204	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
690850003205	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
690850003206	active site
690850003207	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
690850003208	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
690850003209	Flavoprotein; Region: Flavoprotein; pfam02441
690850003210	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
690850003211	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
690850003212	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
690850003213	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
690850003214	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850003215	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
690850003216	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
690850003217	dimer interface [polypeptide binding]; other site
690850003218	PYR/PP interface [polypeptide binding]; other site
690850003219	TPP binding site [chemical binding]; other site
690850003220	substrate binding site [chemical binding]; other site
690850003221	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
690850003222	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
690850003223	TPP-binding site [chemical binding]; other site
690850003224	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
690850003225	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
690850003226	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
690850003227	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
690850003228	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
690850003229	active site
690850003230	dimer interface [polypeptide binding]; other site
690850003231	effector binding site; other site
690850003232	TSCPD domain; Region: TSCPD; pfam12637
690850003233	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
690850003234	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
690850003235	BON domain; Region: BON; pfam04972
690850003236	BON domain; Region: BON; pfam04972
690850003237	BON domain; Region: BON; pfam04972
690850003238	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
690850003239	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
690850003240	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
690850003241	Tetramer interface [polypeptide binding]; other site
690850003242	active site
690850003243	FMN-binding site [chemical binding]; other site
690850003244	TraB family; Region: TraB; pfam01963
690850003245	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
690850003246	Uncharacterized conserved protein [Function unknown]; Region: COG1656
690850003247	Protein of unknown function DUF82; Region: DUF82; pfam01927
690850003248	Peptidase family M48; Region: Peptidase_M48; pfam01435
690850003249	Disaggregatase related; Region: Disaggr_assoc; pfam08480
690850003250	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
690850003251	6-phosphofructo-2-kinase; Region: 6PF2K; pfam01591
690850003252	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
690850003253	catalytic core [active]
690850003254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850003255	active site
690850003256	phosphorylation site [posttranslational modification]
690850003257	intermolecular recognition site; other site
690850003258	dimerization interface [polypeptide binding]; other site
690850003259	Response regulator receiver domain; Region: Response_reg; pfam00072
690850003260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850003261	active site
690850003262	phosphorylation site [posttranslational modification]
690850003263	intermolecular recognition site; other site
690850003264	dimerization interface [polypeptide binding]; other site
690850003265	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850003266	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850003267	metal binding site [ion binding]; metal-binding site
690850003268	active site
690850003269	I-site; other site
690850003270	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
690850003271	Response regulator receiver domain; Region: Response_reg; pfam00072
690850003272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850003273	active site
690850003274	phosphorylation site [posttranslational modification]
690850003275	intermolecular recognition site; other site
690850003276	dimerization interface [polypeptide binding]; other site
690850003277	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850003278	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850003279	metal binding site [ion binding]; metal-binding site
690850003280	active site
690850003281	I-site; other site
690850003282	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
690850003283	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
690850003284	Walker A/P-loop; other site
690850003285	ATP binding site [chemical binding]; other site
690850003286	Q-loop/lid; other site
690850003287	ABC transporter signature motif; other site
690850003288	Walker B; other site
690850003289	D-loop; other site
690850003290	H-loop/switch region; other site
690850003291	FtsX-like permease family; Region: FtsX; pfam02687
690850003292	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
690850003293	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
690850003294	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
690850003295	Esterase/lipase [General function prediction only]; Region: COG1647
690850003296	HAMP domain; Region: HAMP; pfam00672
690850003297	dimerization interface [polypeptide binding]; other site
690850003298	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850003299	PAS domain; Region: PAS_9; pfam13426
690850003300	putative active site [active]
690850003301	heme pocket [chemical binding]; other site
690850003302	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850003303	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850003304	dimer interface [polypeptide binding]; other site
690850003305	putative CheW interface [polypeptide binding]; other site
690850003306	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850003307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850003308	dimer interface [polypeptide binding]; other site
690850003309	phosphorylation site [posttranslational modification]
690850003310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850003311	ATP binding site [chemical binding]; other site
690850003312	Mg2+ binding site [ion binding]; other site
690850003313	G-X-G motif; other site
690850003314	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850003315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850003316	active site
690850003317	phosphorylation site [posttranslational modification]
690850003318	intermolecular recognition site; other site
690850003319	dimerization interface [polypeptide binding]; other site
690850003320	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
690850003321	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
690850003322	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
690850003323	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850003324	Coenzyme A binding pocket [chemical binding]; other site
690850003325	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
690850003326	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850003327	FeS/SAM binding site; other site
690850003328	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
690850003329	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
690850003330	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
690850003331	Walker A/P-loop; other site
690850003332	ATP binding site [chemical binding]; other site
690850003333	Q-loop/lid; other site
690850003334	ABC transporter signature motif; other site
690850003335	Walker B; other site
690850003336	D-loop; other site
690850003337	H-loop/switch region; other site
690850003338	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
690850003339	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850003340	dimer interface [polypeptide binding]; other site
690850003341	conserved gate region; other site
690850003342	putative PBP binding loops; other site
690850003343	ABC-ATPase subunit interface; other site
690850003344	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
690850003345	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
690850003346	substrate binding pocket [chemical binding]; other site
690850003347	membrane-bound complex binding site; other site
690850003348	hinge residues; other site
690850003349	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
690850003350	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
690850003351	active site
690850003352	dimer interface [polypeptide binding]; other site
690850003353	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
690850003354	dimer interface [polypeptide binding]; other site
690850003355	active site
690850003356	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
690850003357	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850003358	Coenzyme A binding pocket [chemical binding]; other site
690850003359	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
690850003360	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850003361	Coenzyme A binding pocket [chemical binding]; other site
690850003362	Rubrerythrin [Energy production and conversion]; Region: COG1592
690850003363	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
690850003364	iron binding site [ion binding]; other site
690850003365	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
690850003366	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
690850003367	active site
690850003368	PHP-associated; Region: PHP_C; pfam13263
690850003369	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850003370	Coenzyme A binding pocket [chemical binding]; other site
690850003371	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
690850003372	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
690850003373	Dynamin family; Region: Dynamin_N; pfam00350
690850003374	G1 box; other site
690850003375	GTP/Mg2+ binding site [chemical binding]; other site
690850003376	G2 box; other site
690850003377	Switch I region; other site
690850003378	G3 box; other site
690850003379	Switch II region; other site
690850003380	G4 box; other site
690850003381	G5 box; other site
690850003382	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
690850003383	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
690850003384	homodimer interface [polypeptide binding]; other site
690850003385	substrate-cofactor binding pocket; other site
690850003386	Aminotransferase class IV; Region: Aminotran_4; pfam01063
690850003387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850003388	catalytic residue [active]
690850003389	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
690850003390	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
690850003391	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
690850003392	Glutamine amidotransferase class-I; Region: GATase; pfam00117
690850003393	glutamine binding [chemical binding]; other site
690850003394	catalytic triad [active]
690850003395	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850003396	dimer interface [polypeptide binding]; other site
690850003397	phosphorylation site [posttranslational modification]
690850003398	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850003399	ATP binding site [chemical binding]; other site
690850003400	Mg2+ binding site [ion binding]; other site
690850003401	G-X-G motif; other site
690850003402	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
690850003403	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850003404	dimerization interface [polypeptide binding]; other site
690850003405	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850003406	dimer interface [polypeptide binding]; other site
690850003407	phosphorylation site [posttranslational modification]
690850003408	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850003409	ATP binding site [chemical binding]; other site
690850003410	Mg2+ binding site [ion binding]; other site
690850003411	G-X-G motif; other site
690850003412	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
690850003413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850003414	active site
690850003415	phosphorylation site [posttranslational modification]
690850003416	intermolecular recognition site; other site
690850003417	dimerization interface [polypeptide binding]; other site
690850003418	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
690850003419	DNA binding site [nucleotide binding]
690850003420	Protein kinase domain; Region: Pkinase; pfam00069
690850003421	Catalytic domain of Protein Kinases; Region: PKc; cd00180
690850003422	active site
690850003423	ATP binding site [chemical binding]; other site
690850003424	substrate binding site [chemical binding]; other site
690850003425	activation loop (A-loop); other site
690850003426	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
690850003427	Response regulator receiver domain; Region: Response_reg; pfam00072
690850003428	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850003429	active site
690850003430	phosphorylation site [posttranslational modification]
690850003431	intermolecular recognition site; other site
690850003432	dimerization interface [polypeptide binding]; other site
690850003433	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850003434	TPR motif; other site
690850003435	TPR repeat; Region: TPR_11; pfam13414
690850003436	binding surface
690850003437	Tetratricopeptide repeat; Region: TPR_16; pfam13432
690850003438	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850003439	TPR motif; other site
690850003440	binding surface
690850003441	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
690850003442	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
690850003443	NAD binding site [chemical binding]; other site
690850003444	catalytic Zn binding site [ion binding]; other site
690850003445	structural Zn binding site [ion binding]; other site
690850003446	S-adenosylmethionine synthetase; Validated; Region: PRK05250
690850003447	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
690850003448	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
690850003449	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
690850003450	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
690850003451	Bacterial sugar transferase; Region: Bac_transf; pfam02397
690850003452	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
690850003453	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
690850003454	SLBB domain; Region: SLBB; pfam10531
690850003455	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
690850003456	Chain length determinant protein; Region: Wzz; pfam02706
690850003457	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
690850003458	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
690850003459	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
690850003460	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
690850003461	NAD binding site [chemical binding]; other site
690850003462	homotetramer interface [polypeptide binding]; other site
690850003463	homodimer interface [polypeptide binding]; other site
690850003464	active site
690850003465	substrate binding site [chemical binding]; other site
690850003466	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
690850003467	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
690850003468	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850003469	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850003470	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
690850003471	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
690850003472	active site
690850003473	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
690850003474	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
690850003475	Right handed beta helix region; Region: Beta_helix; pfam13229
690850003476	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
690850003477	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
690850003478	putative active site [active]
690850003479	putative metal binding site [ion binding]; other site
690850003480	FemAB family; Region: FemAB; pfam02388
690850003481	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
690850003482	Right handed beta helix region; Region: Beta_helix; pfam13229
690850003483	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
690850003484	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
690850003485	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
690850003486	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
690850003487	RibD C-terminal domain; Region: RibD_C; cl17279
690850003488	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
690850003489	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830
690850003490	active site
690850003491	ADP/pyrophosphate binding site [chemical binding]; other site
690850003492	dimerization interface [polypeptide binding]; other site
690850003493	allosteric effector site; other site
690850003494	fructose-1,6-bisphosphate binding site; other site
690850003495	HDOD domain; Region: HDOD; pfam08668
690850003496	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850003497	dimer interface [polypeptide binding]; other site
690850003498	phosphorylation site [posttranslational modification]
690850003499	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
690850003500	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
690850003501	putative NAD(P) binding site [chemical binding]; other site
690850003502	Nitrogen regulatory protein P-II; Region: P-II; smart00938
690850003503	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
690850003504	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
690850003505	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
690850003506	putative cation:proton antiport protein; Provisional; Region: PRK10669
690850003507	TrkA-N domain; Region: TrkA_N; pfam02254
690850003508	TrkA-C domain; Region: TrkA_C; pfam02080
690850003509	Protein of unknown function (DUF401); Region: DUF401; cl00830
690850003510	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
690850003511	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
690850003512	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
690850003513	shikimate binding site; other site
690850003514	NAD(P) binding site [chemical binding]; other site
690850003515	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
690850003516	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
690850003517	N-acetyl-D-glucosamine binding site [chemical binding]; other site
690850003518	catalytic residue [active]
690850003519	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
690850003520	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
690850003521	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
690850003522	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
690850003523	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
690850003524	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
690850003525	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
690850003526	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
690850003527	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
690850003528	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
690850003529	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
690850003530	flagellar motor switch protein; Validated; Region: fliN; PRK05698
690850003531	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
690850003532	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
690850003533	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
690850003534	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
690850003535	flagellar motor protein MotS; Reviewed; Region: PRK06925
690850003536	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
690850003537	ligand binding site [chemical binding]; other site
690850003538	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
690850003539	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
690850003540	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
690850003541	ligand binding site [chemical binding]; other site
690850003542	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
690850003543	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
690850003544	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
690850003545	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
690850003546	catalytic residue [active]
690850003547	GTPase Era; Reviewed; Region: era; PRK00089
690850003548	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
690850003549	G1 box; other site
690850003550	GTP/Mg2+ binding site [chemical binding]; other site
690850003551	Switch I region; other site
690850003552	G2 box; other site
690850003553	Switch II region; other site
690850003554	G3 box; other site
690850003555	G4 box; other site
690850003556	G5 box; other site
690850003557	KH domain; Region: KH_2; pfam07650
690850003558	G-X-X-G motif; other site
690850003559	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
690850003560	active site clefts [active]
690850003561	zinc binding site [ion binding]; other site
690850003562	dimer interface [polypeptide binding]; other site
690850003563	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850003564	active site
690850003565	phosphorylation site [posttranslational modification]
690850003566	intermolecular recognition site; other site
690850003567	dimerization interface [polypeptide binding]; other site
690850003568	PAS fold; Region: PAS_4; pfam08448
690850003569	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850003570	putative active site [active]
690850003571	heme pocket [chemical binding]; other site
690850003572	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
690850003573	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850003574	putative active site [active]
690850003575	heme pocket [chemical binding]; other site
690850003576	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850003577	dimer interface [polypeptide binding]; other site
690850003578	phosphorylation site [posttranslational modification]
690850003579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850003580	ATP binding site [chemical binding]; other site
690850003581	Mg2+ binding site [ion binding]; other site
690850003582	G-X-G motif; other site
690850003583	Response regulator receiver domain; Region: Response_reg; pfam00072
690850003584	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850003585	active site
690850003586	phosphorylation site [posttranslational modification]
690850003587	intermolecular recognition site; other site
690850003588	dimerization interface [polypeptide binding]; other site
690850003589	PAS fold; Region: PAS_4; pfam08448
690850003590	PAS domain; Region: PAS_9; pfam13426
690850003591	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850003592	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850003593	ATP binding site [chemical binding]; other site
690850003594	Mg2+ binding site [ion binding]; other site
690850003595	G-X-G motif; other site
690850003596	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14460
690850003597	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850003598	FeS/SAM binding site; other site
690850003599	Domain of unknown function DUF39; Region: DUF39; pfam01837
690850003600	DnaA N-terminal domain; Region: DnaA_N; pfam11638
690850003601	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
690850003602	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850003603	Walker A motif; other site
690850003604	ATP binding site [chemical binding]; other site
690850003605	Walker B motif; other site
690850003606	arginine finger; other site
690850003607	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
690850003608	DnaA box-binding interface [nucleotide binding]; other site
690850003609	DNA polymerase III subunit beta; Provisional; Region: PRK14947
690850003610	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
690850003611	putative DNA binding surface [nucleotide binding]; other site
690850003612	dimer interface [polypeptide binding]; other site
690850003613	beta-clamp/clamp loader binding surface; other site
690850003614	beta-clamp/translesion DNA polymerase binding surface; other site
690850003615	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
690850003616	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850003617	ATP binding site [chemical binding]; other site
690850003618	Mg2+ binding site [ion binding]; other site
690850003619	G-X-G motif; other site
690850003620	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
690850003621	anchoring element; other site
690850003622	dimer interface [polypeptide binding]; other site
690850003623	ATP binding site [chemical binding]; other site
690850003624	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
690850003625	active site
690850003626	putative metal-binding site [ion binding]; other site
690850003627	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
690850003628	DNA gyrase subunit A; Validated; Region: PRK05560
690850003629	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
690850003630	CAP-like domain; other site
690850003631	active site
690850003632	primary dimer interface [polypeptide binding]; other site
690850003633	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
690850003634	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
690850003635	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
690850003636	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
690850003637	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
690850003638	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
690850003639	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850003640	binding surface
690850003641	TPR motif; other site
690850003642	Tetratricopeptide repeat; Region: TPR_12; pfam13424
690850003643	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
690850003644	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
690850003645	putative ligand binding site [chemical binding]; other site
690850003646	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
690850003647	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
690850003648	RNA binding surface [nucleotide binding]; other site
690850003649	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
690850003650	active site
690850003651	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
690850003652	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
690850003653	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
690850003654	Walker A/P-loop; other site
690850003655	ATP binding site [chemical binding]; other site
690850003656	Q-loop/lid; other site
690850003657	ABC transporter signature motif; other site
690850003658	Walker B; other site
690850003659	D-loop; other site
690850003660	H-loop/switch region; other site
690850003661	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
690850003662	FtsX-like permease family; Region: FtsX; pfam02687
690850003663	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
690850003664	Major Facilitator Superfamily; Region: MFS_1; pfam07690
690850003665	putative substrate translocation pore; other site
690850003666	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
690850003667	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
690850003668	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
690850003669	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
690850003670	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
690850003671	active site
690850003672	HIGH motif; other site
690850003673	nucleotide binding site [chemical binding]; other site
690850003674	active site
690850003675	KMSKS motif; other site
690850003676	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
690850003677	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850003678	dimerization interface [polypeptide binding]; other site
690850003679	PAS domain; Region: PAS_9; pfam13426
690850003680	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850003681	putative active site [active]
690850003682	heme pocket [chemical binding]; other site
690850003683	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850003684	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850003685	dimer interface [polypeptide binding]; other site
690850003686	putative CheW interface [polypeptide binding]; other site
690850003687	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
690850003688	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
690850003689	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
690850003690	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
690850003691	Transposase; Region: DEDD_Tnp_IS110; pfam01548
690850003692	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
690850003693	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
690850003694	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
690850003695	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
690850003696	HlyD family secretion protein; Region: HlyD_3; pfam13437
690850003697	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
690850003698	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
690850003699	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
690850003700	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
690850003701	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
690850003702	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
690850003703	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
690850003704	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
690850003705	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
690850003706	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
690850003707	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
690850003708	catalytic triad [active]
690850003709	Methylamine utilisation protein MauE; Region: MauE; pfam07291
690850003710	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
690850003711	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
690850003712	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
690850003713	catalytic residues [active]
690850003714	Response regulator receiver domain; Region: Response_reg; pfam00072
690850003715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850003716	active site
690850003717	phosphorylation site [posttranslational modification]
690850003718	intermolecular recognition site; other site
690850003719	dimerization interface [polypeptide binding]; other site
690850003720	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
690850003721	anti sigma factor interaction site; other site
690850003722	regulatory phosphorylation site [posttranslational modification]; other site
690850003723	PAS domain S-box; Region: sensory_box; TIGR00229
690850003724	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850003725	putative active site [active]
690850003726	heme pocket [chemical binding]; other site
690850003727	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850003728	dimer interface [polypeptide binding]; other site
690850003729	phosphorylation site [posttranslational modification]
690850003730	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850003731	ATP binding site [chemical binding]; other site
690850003732	Mg2+ binding site [ion binding]; other site
690850003733	G-X-G motif; other site
690850003734	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
690850003735	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
690850003736	putative ligand binding site [chemical binding]; other site
690850003737	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
690850003738	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
690850003739	active site
690850003740	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
690850003741	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850003742	putative ADP-binding pocket [chemical binding]; other site
690850003743	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850003744	binding surface
690850003745	TPR repeat; Region: TPR_11; pfam13414
690850003746	TPR motif; other site
690850003747	TPR repeat; Region: TPR_11; pfam13414
690850003748	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850003749	binding surface
690850003750	TPR motif; other site
690850003751	TPR repeat; Region: TPR_11; pfam13414
690850003752	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
690850003753	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
690850003754	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
690850003755	protein binding site [polypeptide binding]; other site
690850003756	type II secretion system protein D; Region: type_II_gspD; TIGR02517
690850003757	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
690850003758	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
690850003759	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
690850003760	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
690850003761	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
690850003762	type II secretion system protein E; Region: type_II_gspE; TIGR02533
690850003763	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
690850003764	Walker A motif; other site
690850003765	ATP binding site [chemical binding]; other site
690850003766	Walker B motif; other site
690850003767	type II secretion system protein F; Region: GspF; TIGR02120
690850003768	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
690850003769	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
690850003770	AAA domain; Region: AAA_22; pfam13401
690850003771	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
690850003772	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
690850003773	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
690850003774	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
690850003775	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
690850003776	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
690850003777	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
690850003778	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
690850003779	EcsC protein family; Region: EcsC; pfam12787
690850003780	DNA topoisomerase I; Validated; Region: PRK06599
690850003781	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
690850003782	active site
690850003783	interdomain interaction site; other site
690850003784	putative metal-binding site [ion binding]; other site
690850003785	nucleotide binding site [chemical binding]; other site
690850003786	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
690850003787	domain I; other site
690850003788	DNA binding groove [nucleotide binding]
690850003789	phosphate binding site [ion binding]; other site
690850003790	domain II; other site
690850003791	domain III; other site
690850003792	nucleotide binding site [chemical binding]; other site
690850003793	catalytic site [active]
690850003794	domain IV; other site
690850003795	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
690850003796	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
690850003797	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
690850003798	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
690850003799	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
690850003800	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
690850003801	non-specific DNA binding site [nucleotide binding]; other site
690850003802	salt bridge; other site
690850003803	sequence-specific DNA binding site [nucleotide binding]; other site
690850003804	Cupin domain; Region: Cupin_2; pfam07883
690850003805	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
690850003806	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
690850003807	acyl-activating enzyme (AAE) consensus motif; other site
690850003808	AMP binding site [chemical binding]; other site
690850003809	active site
690850003810	CoA binding site [chemical binding]; other site
690850003811	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
690850003812	FAD binding domain; Region: FAD_binding_4; pfam01565
690850003813	Berberine and berberine like; Region: BBE; pfam08031
690850003814	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
690850003815	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
690850003816	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850003817	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
690850003818	Walker A/P-loop; other site
690850003819	ATP binding site [chemical binding]; other site
690850003820	Q-loop/lid; other site
690850003821	ABC transporter signature motif; other site
690850003822	Walker B; other site
690850003823	D-loop; other site
690850003824	H-loop/switch region; other site
690850003825	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
690850003826	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
690850003827	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
690850003828	Phosphopantetheine attachment site; Region: PP-binding; cl09936
690850003829	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
690850003830	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
690850003831	Walker A/P-loop; other site
690850003832	ATP binding site [chemical binding]; other site
690850003833	Q-loop/lid; other site
690850003834	ABC transporter signature motif; other site
690850003835	Walker B; other site
690850003836	D-loop; other site
690850003837	H-loop/switch region; other site
690850003838	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
690850003839	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
690850003840	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
690850003841	TM-ABC transporter signature motif; other site
690850003842	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
690850003843	active site
690850003844	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
690850003845	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
690850003846	TM-ABC transporter signature motif; other site
690850003847	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
690850003848	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
690850003849	putative ligand binding site [chemical binding]; other site
690850003850	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
690850003851	active site
690850003852	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
690850003853	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
690850003854	NAD(P) binding site [chemical binding]; other site
690850003855	catalytic residues [active]
690850003856	putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494
690850003857	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
690850003858	Putative Fe-S cluster; Region: FeS; cl17515
690850003859	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
690850003860	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
690850003861	Walker A/P-loop; other site
690850003862	ATP binding site [chemical binding]; other site
690850003863	Q-loop/lid; other site
690850003864	ABC transporter signature motif; other site
690850003865	Walker B; other site
690850003866	D-loop; other site
690850003867	H-loop/switch region; other site
690850003868	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850003869	dimer interface [polypeptide binding]; other site
690850003870	conserved gate region; other site
690850003871	putative PBP binding loops; other site
690850003872	ABC-ATPase subunit interface; other site
690850003873	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
690850003874	putative active site pocket [active]
690850003875	dimerization interface [polypeptide binding]; other site
690850003876	putative catalytic residue [active]
690850003877	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
690850003878	B12 binding site [chemical binding]; other site
690850003879	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
690850003880	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850003881	FeS/SAM binding site; other site
690850003882	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816
690850003883	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
690850003884	dimer interface [polypeptide binding]; other site
690850003885	active site
690850003886	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850003887	S-adenosylmethionine binding site [chemical binding]; other site
690850003888	serine O-acetyltransferase; Region: cysE; TIGR01172
690850003889	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
690850003890	trimer interface [polypeptide binding]; other site
690850003891	active site
690850003892	substrate binding site [chemical binding]; other site
690850003893	CoA binding site [chemical binding]; other site
690850003894	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
690850003895	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
690850003896	dimer interface [polypeptide binding]; other site
690850003897	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850003898	catalytic residue [active]
690850003899	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
690850003900	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
690850003901	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
690850003902	catalytic residue [active]
690850003903	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
690850003904	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
690850003905	trimerization site [polypeptide binding]; other site
690850003906	active site
690850003907	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
690850003908	NifU-like domain; Region: NifU; cl00484
690850003909	TPR repeat; Region: TPR_11; pfam13414
690850003910	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850003911	binding surface
690850003912	TPR motif; other site
690850003913	Tetratricopeptide repeat; Region: TPR_16; pfam13432
690850003914	PAS domain S-box; Region: sensory_box; TIGR00229
690850003915	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850003916	putative active site [active]
690850003917	heme pocket [chemical binding]; other site
690850003918	PAS domain S-box; Region: sensory_box; TIGR00229
690850003919	PAS domain; Region: PAS_8; pfam13188
690850003920	PAS domain S-box; Region: sensory_box; TIGR00229
690850003921	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850003922	putative active site [active]
690850003923	heme pocket [chemical binding]; other site
690850003924	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850003925	dimer interface [polypeptide binding]; other site
690850003926	phosphorylation site [posttranslational modification]
690850003927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850003928	ATP binding site [chemical binding]; other site
690850003929	Mg2+ binding site [ion binding]; other site
690850003930	G-X-G motif; other site
690850003931	Response regulator receiver domain; Region: Response_reg; pfam00072
690850003932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850003933	active site
690850003934	phosphorylation site [posttranslational modification]
690850003935	intermolecular recognition site; other site
690850003936	dimerization interface [polypeptide binding]; other site
690850003937	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
690850003938	putative binding surface; other site
690850003939	active site
690850003940	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
690850003941	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
690850003942	substrate binding site; other site
690850003943	tetramer interface; other site
690850003944	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
690850003945	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
690850003946	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
690850003947	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
690850003948	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
690850003949	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
690850003950	glycerate kinase; Region: TIGR00045
690850003951	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
690850003952	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
690850003953	catalytic site [active]
690850003954	putative active site [active]
690850003955	putative substrate binding site [chemical binding]; other site
690850003956	Helicase and RNase D C-terminal; Region: HRDC; smart00341
690850003957	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
690850003958	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
690850003959	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
690850003960	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
690850003961	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
690850003962	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850003963	dimerization interface [polypeptide binding]; other site
690850003964	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850003965	dimer interface [polypeptide binding]; other site
690850003966	putative CheW interface [polypeptide binding]; other site
690850003967	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
690850003968	PAS domain S-box; Region: sensory_box; TIGR00229
690850003969	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
690850003970	putative active site [active]
690850003971	heme pocket [chemical binding]; other site
690850003972	PAS domain S-box; Region: sensory_box; TIGR00229
690850003973	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
690850003974	putative active site [active]
690850003975	heme pocket [chemical binding]; other site
690850003976	PAS domain S-box; Region: sensory_box; TIGR00229
690850003977	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850003978	putative active site [active]
690850003979	heme pocket [chemical binding]; other site
690850003980	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850003981	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850003982	metal binding site [ion binding]; metal-binding site
690850003983	active site
690850003984	I-site; other site
690850003985	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
690850003986	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
690850003987	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
690850003988	catalytic triad [active]
690850003989	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
690850003990	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
690850003991	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
690850003992	DNA binding residues [nucleotide binding]
690850003993	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
690850003994	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
690850003995	ATP binding site [chemical binding]; other site
690850003996	putative Mg++ binding site [ion binding]; other site
690850003997	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
690850003998	nucleotide binding region [chemical binding]; other site
690850003999	ATP-binding site [chemical binding]; other site
690850004000	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
690850004001	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
690850004002	active site
690850004003	substrate binding site [chemical binding]; other site
690850004004	catalytic site [active]
690850004005	Protein of unknown function (DUF721); Region: DUF721; pfam05258
690850004006	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
690850004007	putative DNA binding site [nucleotide binding]; other site
690850004008	putative Zn2+ binding site [ion binding]; other site
690850004009	Methyltransferase domain; Region: Methyltransf_31; pfam13847
690850004010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850004011	S-adenosylmethionine binding site [chemical binding]; other site
690850004012	Adenosylhomocysteinase; Provisional; Region: PTZ00075
690850004013	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
690850004014	homotetramer interface [polypeptide binding]; other site
690850004015	ligand binding site [chemical binding]; other site
690850004016	catalytic site [active]
690850004017	NAD binding site [chemical binding]; other site
690850004018	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
690850004019	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850004020	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
690850004021	putative substrate translocation pore; other site
690850004022	Major Facilitator Superfamily; Region: MFS_1; pfam07690
690850004023	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
690850004024	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
690850004025	active site
690850004026	Riboflavin kinase; Region: Flavokinase; pfam01687
690850004027	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
690850004028	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
690850004029	Cl- selectivity filter; other site
690850004030	Cl- binding residues [ion binding]; other site
690850004031	pore gating glutamate residue; other site
690850004032	dimer interface [polypeptide binding]; other site
690850004033	FOG: CBS domain [General function prediction only]; Region: COG0517
690850004034	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
690850004035	TQO small subunit DoxD; Region: DoxD; pfam04173
690850004036	PAS fold; Region: PAS; pfam00989
690850004037	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850004038	putative active site [active]
690850004039	heme pocket [chemical binding]; other site
690850004040	PAS domain S-box; Region: sensory_box; TIGR00229
690850004041	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850004042	putative active site [active]
690850004043	heme pocket [chemical binding]; other site
690850004044	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850004045	putative active site [active]
690850004046	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850004047	heme pocket [chemical binding]; other site
690850004048	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850004049	dimer interface [polypeptide binding]; other site
690850004050	phosphorylation site [posttranslational modification]
690850004051	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850004052	ATP binding site [chemical binding]; other site
690850004053	Mg2+ binding site [ion binding]; other site
690850004054	G-X-G motif; other site
690850004055	Response regulator receiver domain; Region: Response_reg; pfam00072
690850004056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850004057	active site
690850004058	phosphorylation site [posttranslational modification]
690850004059	intermolecular recognition site; other site
690850004060	dimerization interface [polypeptide binding]; other site
690850004061	Methyltransferase domain; Region: Methyltransf_23; pfam13489
690850004062	Methyltransferase domain; Region: Methyltransf_11; pfam08241
690850004063	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
690850004064	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
690850004065	Probable Catalytic site; other site
690850004066	metal-binding site
690850004067	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
690850004068	Ligand binding site; other site
690850004069	Putative Catalytic site; other site
690850004070	DXD motif; other site
690850004071	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
690850004072	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850004073	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
690850004074	putative ADP-binding pocket [chemical binding]; other site
690850004075	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
690850004076	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
690850004077	XdhC Rossmann domain; Region: XdhC_C; pfam13478
690850004078	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
690850004079	metal-binding site
690850004080	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850004081	Zn2+ binding site [ion binding]; other site
690850004082	Mg2+ binding site [ion binding]; other site
690850004083	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
690850004084	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850004085	Walker A motif; other site
690850004086	ATP binding site [chemical binding]; other site
690850004087	Walker B motif; other site
690850004088	arginine finger; other site
690850004089	phage shock protein A; Region: phageshock_pspA; TIGR02977
690850004090	Phage shock protein B; Region: PspB; cl05946
690850004091	PspC domain; Region: PspC; pfam04024
690850004092	phage shock protein C; Region: phageshock_pspC; TIGR02978
690850004093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850004094	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
690850004095	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
690850004096	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
690850004097	ligand binding site [chemical binding]; other site
690850004098	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
690850004099	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
690850004100	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
690850004101	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
690850004102	ligand binding site [chemical binding]; other site
690850004103	flexible hinge region; other site
690850004104	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
690850004105	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
690850004106	hexamer interface [polypeptide binding]; other site
690850004107	ligand binding site [chemical binding]; other site
690850004108	putative active site [active]
690850004109	NAD(P) binding site [chemical binding]; other site
690850004110	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
690850004111	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
690850004112	active site
690850004113	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
690850004114	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
690850004115	ADP binding site [chemical binding]; other site
690850004116	magnesium binding site [ion binding]; other site
690850004117	putative shikimate binding site; other site
690850004118	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850004119	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850004120	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
690850004121	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850004122	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
690850004123	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
690850004124	acyl-activating enzyme (AAE) consensus motif; other site
690850004125	putative AMP binding site [chemical binding]; other site
690850004126	putative active site [active]
690850004127	putative CoA binding site [chemical binding]; other site
690850004128	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
690850004129	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
690850004130	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
690850004131	putative acyl-acceptor binding pocket; other site
690850004132	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
690850004133	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850004134	FeS/SAM binding site; other site
690850004135	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
690850004136	Cytochrome P450; Region: p450; cl12078
690850004137	ABC-2 type transporter; Region: ABC2_membrane; cl17235
690850004138	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
690850004139	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850004140	Walker A/P-loop; other site
690850004141	ATP binding site [chemical binding]; other site
690850004142	Q-loop/lid; other site
690850004143	ABC transporter signature motif; other site
690850004144	Walker B; other site
690850004145	D-loop; other site
690850004146	H-loop/switch region; other site
690850004147	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
690850004148	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
690850004149	HlyD family secretion protein; Region: HlyD_3; pfam13437
690850004150	Uncharacterized conserved protein [Function unknown]; Region: COG3461
690850004151	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
690850004152	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850004153	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850004154	dimer interface [polypeptide binding]; other site
690850004155	putative CheW interface [polypeptide binding]; other site
690850004156	Hemerythrin; Region: Hemerythrin; cd12107
690850004157	Fe binding site [ion binding]; other site
690850004158	Homeodomain-like domain; Region: HTH_23; pfam13384
690850004159	Winged helix-turn helix; Region: HTH_29; pfam13551
690850004160	Homeodomain-like domain; Region: HTH_32; pfam13565
690850004161	DDE superfamily endonuclease; Region: DDE_3; pfam13358
690850004162	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
690850004163	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850004164	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850004165	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
690850004166	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850004167	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
690850004168	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
690850004169	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
690850004170	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
690850004171	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
690850004172	[2Fe-2S] cluster binding site [ion binding]; other site
690850004173	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
690850004174	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
690850004175	NAD(P) binding site [chemical binding]; other site
690850004176	active site
690850004177	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
690850004178	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
690850004179	NAD(P) binding site [chemical binding]; other site
690850004180	active site
690850004181	B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295
690850004182	B12 binding domain; Region: B12-binding; pfam02310
690850004183	B12 binding site [chemical binding]; other site
690850004184	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850004185	FeS/SAM binding site; other site
690850004186	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
690850004187	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850004188	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
690850004189	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; cl17747
690850004190	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850004191	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
690850004192	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
690850004193	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
690850004194	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
690850004195	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
690850004196	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
690850004197	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
690850004198	catalytic core [active]
690850004199	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850004200	S-adenosylmethionine binding site [chemical binding]; other site
690850004201	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
690850004202	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
690850004203	putative active site [active]
690850004204	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850004205	S-adenosylmethionine binding site [chemical binding]; other site
690850004206	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
690850004207	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
690850004208	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
690850004209	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850004210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850004211	ATP binding site [chemical binding]; other site
690850004212	Mg2+ binding site [ion binding]; other site
690850004213	G-X-G motif; other site
690850004214	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
690850004215	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
690850004216	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850004217	binding surface
690850004218	TPR motif; other site
690850004219	TPR repeat; Region: TPR_11; pfam13414
690850004220	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850004221	binding surface
690850004222	TPR motif; other site
690850004223	Tetratricopeptide repeat; Region: TPR_12; pfam13424
690850004224	sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064
690850004225	sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066
690850004226	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
690850004227	Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679
690850004228	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
690850004229	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
690850004230	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
690850004231	catalytic triad [active]
690850004232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
690850004233	active site
690850004234	phosphorylation site [posttranslational modification]
690850004235	intermolecular recognition site; other site
690850004236	dimerization interface [polypeptide binding]; other site
690850004237	TPR repeat; Region: TPR_11; pfam13414
690850004238	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850004239	binding surface
690850004240	TPR motif; other site
690850004241	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850004242	TPR repeat; Region: TPR_11; pfam13414
690850004243	binding surface
690850004244	TPR motif; other site
690850004245	Uncharacterized conserved protein [Function unknown]; Region: COG5276
690850004246	LVIVD repeat; Region: LVIVD; pfam08309
690850004247	PQQ-like domain; Region: PQQ_2; pfam13360
690850004248	LVIVD repeat; Region: LVIVD; pfam08309
690850004249	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
690850004250	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
690850004251	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
690850004252	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
690850004253	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
690850004254	FMN binding site [chemical binding]; other site
690850004255	dimer interface [polypeptide binding]; other site
690850004256	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
690850004257	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
690850004258	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
690850004259	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
690850004260	Substrate binding site; other site
690850004261	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
690850004262	Amino acid permease; Region: AA_permease; pfam00324
690850004263	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
690850004264	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
690850004265	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
690850004266	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831
690850004267	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
690850004268	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
690850004269	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
690850004270	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
690850004271	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
690850004272	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
690850004273	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850004274	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
690850004275	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
690850004276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850004277	active site
690850004278	phosphorylation site [posttranslational modification]
690850004279	intermolecular recognition site; other site
690850004280	dimerization interface [polypeptide binding]; other site
690850004281	LytTr DNA-binding domain; Region: LytTR; smart00850
690850004282	acetyl-CoA synthetase; Provisional; Region: PRK00174
690850004283	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
690850004284	active site
690850004285	CoA binding site [chemical binding]; other site
690850004286	acyl-activating enzyme (AAE) consensus motif; other site
690850004287	AMP binding site [chemical binding]; other site
690850004288	acetate binding site [chemical binding]; other site
690850004289	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
690850004290	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
690850004291	active site
690850004292	dimer interface [polypeptide binding]; other site
690850004293	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
690850004294	Ligand Binding Site [chemical binding]; other site
690850004295	Molecular Tunnel; other site
690850004296	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
690850004297	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
690850004298	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
690850004299	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
690850004300	Ligand Binding Site [chemical binding]; other site
690850004301	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
690850004302	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
690850004303	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
690850004304	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
690850004305	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
690850004306	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
690850004307	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
690850004308	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
690850004309	EamA-like transporter family; Region: EamA; pfam00892
690850004310	EamA-like transporter family; Region: EamA; pfam00892
690850004311	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
690850004312	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
690850004313	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
690850004314	Ligand Binding Site [chemical binding]; other site
690850004315	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
690850004316	Protein of unknown function (DUF1207); Region: DUF1207; pfam06727
690850004317	PAS domain; Region: PAS_9; pfam13426
690850004318	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850004319	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850004320	ATP binding site [chemical binding]; other site
690850004321	Mg2+ binding site [ion binding]; other site
690850004322	G-X-G motif; other site
690850004323	Peptidase S8 family domain in Protein convertases; Region: Peptidases_S8_Protein_convertases_Kexins_Furin-lik; cd04059
690850004324	calcium binding site 1 [ion binding]; other site
690850004325	active site
690850004326	catalytic triad [active]
690850004327	calcium binding site 2 [ion binding]; other site
690850004328	calcium binding site 3 [ion binding]; other site
690850004329	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
690850004330	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
690850004331	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
690850004332	active site
690850004333	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
690850004334	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
690850004335	Ribonuclease P; Region: Ribonuclease_P; pfam00825
690850004336	Haemolytic domain; Region: Haemolytic; pfam01809
690850004337	membrane protein insertase; Provisional; Region: PRK01318
690850004338	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
690850004339	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
690850004340	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
690850004341	G-X-X-G motif; other site
690850004342	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
690850004343	RxxxH motif; other site
690850004344	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
690850004345	sequence-specific DNA binding site [nucleotide binding]; other site
690850004346	salt bridge; other site
690850004347	HipA N-terminal domain; Region: Couple_hipA; cl11853
690850004348	HipA-like N-terminal domain; Region: HipA_N; pfam07805
690850004349	HipA-like C-terminal domain; Region: HipA_C; pfam07804
690850004350	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
690850004351	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
690850004352	trmE is a tRNA modification GTPase; Region: trmE; cd04164
690850004353	G1 box; other site
690850004354	GTP/Mg2+ binding site [chemical binding]; other site
690850004355	Switch I region; other site
690850004356	G2 box; other site
690850004357	Switch II region; other site
690850004358	G3 box; other site
690850004359	G4 box; other site
690850004360	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
690850004361	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
690850004362	Part of AAA domain; Region: AAA_19; pfam13245
690850004363	Family description; Region: UvrD_C_2; pfam13538
690850004364	Response regulator receiver domain; Region: Response_reg; pfam00072
690850004365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850004366	active site
690850004367	phosphorylation site [posttranslational modification]
690850004368	intermolecular recognition site; other site
690850004369	dimerization interface [polypeptide binding]; other site
690850004370	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
690850004371	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
690850004372	oligomer interface [polypeptide binding]; other site
690850004373	metal binding site [ion binding]; metal-binding site
690850004374	metal binding site [ion binding]; metal-binding site
690850004375	Cl binding site [ion binding]; other site
690850004376	aspartate ring; other site
690850004377	basic sphincter; other site
690850004378	putative hydrophobic gate; other site
690850004379	periplasmic entrance; other site
690850004380	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
690850004381	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850004382	PAS domain; Region: PAS_9; pfam13426
690850004383	putative active site [active]
690850004384	heme pocket [chemical binding]; other site
690850004385	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850004386	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850004387	metal binding site [ion binding]; metal-binding site
690850004388	active site
690850004389	I-site; other site
690850004390	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
690850004391	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
690850004392	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850004393	binding surface
690850004394	TPR motif; other site
690850004395	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850004396	binding surface
690850004397	TPR motif; other site
690850004398	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850004399	binding surface
690850004400	TPR motif; other site
690850004401	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850004402	binding surface
690850004403	TPR motif; other site
690850004404	Rubrerythrin [Energy production and conversion]; Region: COG1592
690850004405	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
690850004406	binuclear metal center [ion binding]; other site
690850004407	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
690850004408	iron binding site [ion binding]; other site
690850004409	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
690850004410	metal binding site 2 [ion binding]; metal-binding site
690850004411	putative DNA binding helix; other site
690850004412	metal binding site 1 [ion binding]; metal-binding site
690850004413	dimer interface [polypeptide binding]; other site
690850004414	structural Zn2+ binding site [ion binding]; other site
690850004415	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
690850004416	ATP cone domain; Region: ATP-cone; pfam03477
690850004417	Class III ribonucleotide reductase; Region: RNR_III; cd01675
690850004418	effector binding site; other site
690850004419	active site
690850004420	Zn binding site [ion binding]; other site
690850004421	glycine loop; other site
690850004422	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
690850004423	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
690850004424	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
690850004425	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
690850004426	putative hydrophobic ligand binding site [chemical binding]; other site
690850004427	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850004428	dimer interface [polypeptide binding]; other site
690850004429	phosphorylation site [posttranslational modification]
690850004430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850004431	ATP binding site [chemical binding]; other site
690850004432	Mg2+ binding site [ion binding]; other site
690850004433	G-X-G motif; other site
690850004434	Response regulator receiver domain; Region: Response_reg; pfam00072
690850004435	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850004436	active site
690850004437	phosphorylation site [posttranslational modification]
690850004438	intermolecular recognition site; other site
690850004439	dimerization interface [polypeptide binding]; other site
690850004440	NAD synthetase; Provisional; Region: PRK13981
690850004441	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
690850004442	multimer interface [polypeptide binding]; other site
690850004443	active site
690850004444	catalytic triad [active]
690850004445	protein interface 1 [polypeptide binding]; other site
690850004446	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
690850004447	homodimer interface [polypeptide binding]; other site
690850004448	NAD binding pocket [chemical binding]; other site
690850004449	ATP binding pocket [chemical binding]; other site
690850004450	Mg binding site [ion binding]; other site
690850004451	active-site loop [active]
690850004452	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
690850004453	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
690850004454	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
690850004455	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850004456	binding surface
690850004457	TPR motif; other site
690850004458	TPR repeat; Region: TPR_11; pfam13414
690850004459	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
690850004460	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
690850004461	HAMP domain; Region: HAMP; pfam00672
690850004462	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850004463	dimer interface [polypeptide binding]; other site
690850004464	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
690850004465	putative CheW interface [polypeptide binding]; other site
690850004466	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
690850004467	putative binding surface; other site
690850004468	active site
690850004469	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850004470	ATP binding site [chemical binding]; other site
690850004471	Mg2+ binding site [ion binding]; other site
690850004472	G-X-G motif; other site
690850004473	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
690850004474	Response regulator receiver domain; Region: Response_reg; pfam00072
690850004475	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850004476	active site
690850004477	phosphorylation site [posttranslational modification]
690850004478	intermolecular recognition site; other site
690850004479	dimerization interface [polypeptide binding]; other site
690850004480	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
690850004481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850004482	active site
690850004483	phosphorylation site [posttranslational modification]
690850004484	intermolecular recognition site; other site
690850004485	dimerization interface [polypeptide binding]; other site
690850004486	CheB methylesterase; Region: CheB_methylest; pfam01339
690850004487	Response regulator receiver domain; Region: Response_reg; pfam00072
690850004488	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850004489	active site
690850004490	phosphorylation site [posttranslational modification]
690850004491	intermolecular recognition site; other site
690850004492	dimerization interface [polypeptide binding]; other site
690850004493	PAS fold; Region: PAS_7; pfam12860
690850004494	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
690850004495	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850004496	PAS fold; Region: PAS_3; pfam08447
690850004497	putative active site [active]
690850004498	heme pocket [chemical binding]; other site
690850004499	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850004500	dimer interface [polypeptide binding]; other site
690850004501	phosphorylation site [posttranslational modification]
690850004502	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850004503	ATP binding site [chemical binding]; other site
690850004504	Mg2+ binding site [ion binding]; other site
690850004505	G-X-G motif; other site
690850004506	Response regulator receiver domain; Region: Response_reg; pfam00072
690850004507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850004508	active site
690850004509	phosphorylation site [posttranslational modification]
690850004510	intermolecular recognition site; other site
690850004511	dimerization interface [polypeptide binding]; other site
690850004512	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
690850004513	putative binding surface; other site
690850004514	active site
690850004515	Response regulator receiver domain; Region: Response_reg; pfam00072
690850004516	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850004517	active site
690850004518	phosphorylation site [posttranslational modification]
690850004519	intermolecular recognition site; other site
690850004520	dimerization interface [polypeptide binding]; other site
690850004521	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
690850004522	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
690850004523	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
690850004524	substrate binding site [chemical binding]; other site
690850004525	glutamase interaction surface [polypeptide binding]; other site
690850004526	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
690850004527	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
690850004528	putative active site [active]
690850004529	oxyanion strand; other site
690850004530	catalytic triad [active]
690850004531	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
690850004532	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
690850004533	NADP binding site [chemical binding]; other site
690850004534	homopentamer interface [polypeptide binding]; other site
690850004535	substrate binding site [chemical binding]; other site
690850004536	active site
690850004537	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
690850004538	active site
690850004539	substrate binding site [chemical binding]; other site
690850004540	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
690850004541	FMN binding site [chemical binding]; other site
690850004542	putative catalytic residues [active]
690850004543	SlyX; Region: SlyX; pfam04102
690850004544	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850004545	dimerization interface [polypeptide binding]; other site
690850004546	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850004547	dimer interface [polypeptide binding]; other site
690850004548	putative CheW interface [polypeptide binding]; other site
690850004549	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
690850004550	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
690850004551	HIGH motif; other site
690850004552	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
690850004553	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
690850004554	active site
690850004555	KMSKS motif; other site
690850004556	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
690850004557	tRNA binding surface [nucleotide binding]; other site
690850004558	anticodon binding site; other site
690850004559	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
690850004560	Curli assembly protein CsgE; Region: CsgE; cl08115
690850004561	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
690850004562	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
690850004563	TPR repeat; Region: TPR_11; pfam13414
690850004564	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850004565	binding surface
690850004566	TPR motif; other site
690850004567	TPR repeat; Region: TPR_11; pfam13414
690850004568	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
690850004569	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
690850004570	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
690850004571	Zn binding site [ion binding]; other site
690850004572	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
690850004573	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
690850004574	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
690850004575	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
690850004576	4Fe-4S binding domain; Region: Fer4; cl02805
690850004577	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
690850004578	major curlin subunit; Provisional; Region: csgA; PRK10051
690850004579	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850004580	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850004581	active site
690850004582	phosphorylation site [posttranslational modification]
690850004583	intermolecular recognition site; other site
690850004584	dimerization interface [polypeptide binding]; other site
690850004585	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850004586	Walker A motif; other site
690850004587	ATP binding site [chemical binding]; other site
690850004588	Walker B motif; other site
690850004589	arginine finger; other site
690850004590	PAS domain S-box; Region: sensory_box; TIGR00229
690850004591	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850004592	putative active site [active]
690850004593	heme pocket [chemical binding]; other site
690850004594	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
690850004595	dimer interface [polypeptide binding]; other site
690850004596	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850004597	phosphorylation site [posttranslational modification]
690850004598	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850004599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850004600	active site
690850004601	phosphorylation site [posttranslational modification]
690850004602	intermolecular recognition site; other site
690850004603	dimerization interface [polypeptide binding]; other site
690850004604	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850004605	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850004606	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850004607	Tetratricopeptide repeat; Region: TPR_12; pfam13424
690850004608	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850004609	binding surface
690850004610	TPR motif; other site
690850004611	Tetratricopeptide repeat; Region: TPR_12; pfam13424
690850004612	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850004613	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850004614	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850004615	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
690850004616	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
690850004617	putative homodimer interface [polypeptide binding]; other site
690850004618	putative homotetramer interface [polypeptide binding]; other site
690850004619	putative allosteric switch controlling residues; other site
690850004620	putative metal binding site [ion binding]; other site
690850004621	putative homodimer-homodimer interface [polypeptide binding]; other site
690850004622	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
690850004623	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
690850004624	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
690850004625	active site residue [active]
690850004626	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
690850004627	active site residue [active]
690850004628	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
690850004629	active site residue [active]
690850004630	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
690850004631	active site residue [active]
690850004632	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
690850004633	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
690850004634	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
690850004635	4Fe-4S binding domain; Region: Fer4; pfam00037
690850004636	thiosulfate reductase PhsA; Provisional; Region: PRK15488
690850004637	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
690850004638	putative [Fe4-S4] binding site [ion binding]; other site
690850004639	putative molybdopterin cofactor binding site [chemical binding]; other site
690850004640	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
690850004641	putative molybdopterin cofactor binding site; other site
690850004642	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
690850004643	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850004644	PAS domain; Region: PAS_9; pfam13426
690850004645	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
690850004646	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850004647	Walker A motif; other site
690850004648	ATP binding site [chemical binding]; other site
690850004649	Walker B motif; other site
690850004650	arginine finger; other site
690850004651	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850004652	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850004653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850004654	active site
690850004655	phosphorylation site [posttranslational modification]
690850004656	intermolecular recognition site; other site
690850004657	dimerization interface [polypeptide binding]; other site
690850004658	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850004659	Walker A motif; other site
690850004660	ATP binding site [chemical binding]; other site
690850004661	Walker B motif; other site
690850004662	arginine finger; other site
690850004663	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850004664	HAMP domain; Region: HAMP; pfam00672
690850004665	dimerization interface [polypeptide binding]; other site
690850004666	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850004667	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850004668	dimer interface [polypeptide binding]; other site
690850004669	phosphorylation site [posttranslational modification]
690850004670	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850004671	ATP binding site [chemical binding]; other site
690850004672	Mg2+ binding site [ion binding]; other site
690850004673	G-X-G motif; other site
690850004674	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
690850004675	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
690850004676	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
690850004677	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850004678	Response regulator receiver domain; Region: Response_reg; pfam00072
690850004679	active site
690850004680	phosphorylation site [posttranslational modification]
690850004681	intermolecular recognition site; other site
690850004682	dimerization interface [polypeptide binding]; other site
690850004683	EamA-like transporter family; Region: EamA; pfam00892
690850004684	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
690850004685	active site
690850004686	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
690850004687	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
690850004688	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
690850004689	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
690850004690	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
690850004691	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
690850004692	TPR repeat; Region: TPR_11; pfam13414
690850004693	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850004694	binding surface
690850004695	TPR motif; other site
690850004696	TPR repeat; Region: TPR_11; pfam13414
690850004697	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850004698	TPR repeat; Region: TPR_11; pfam13414
690850004699	binding surface
690850004700	TPR motif; other site
690850004701	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
690850004702	IHF dimer interface [polypeptide binding]; other site
690850004703	IHF - DNA interface [nucleotide binding]; other site
690850004704	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
690850004705	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
690850004706	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
690850004707	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
690850004708	putative active site; other site
690850004709	catalytic triad [active]
690850004710	putative dimer interface [polypeptide binding]; other site
690850004711	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
690850004712	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
690850004713	dimer interface [polypeptide binding]; other site
690850004714	putative functional site; other site
690850004715	putative MPT binding site; other site
690850004716	PBP superfamily domain; Region: PBP_like; pfam12727
690850004717	Glucokinase; Region: Glucokinase; cl17310
690850004718	glucokinase, proteobacterial type; Region: glk; TIGR00749
690850004719	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
690850004720	HDOD domain; Region: HDOD; pfam08668
690850004721	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
690850004722	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
690850004723	Histidine kinase; Region: HisKA_2; pfam07568
690850004724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850004725	ATP binding site [chemical binding]; other site
690850004726	Mg2+ binding site [ion binding]; other site
690850004727	G-X-G motif; other site
690850004728	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
690850004729	active site 1 [active]
690850004730	dimer interface [polypeptide binding]; other site
690850004731	hexamer interface [polypeptide binding]; other site
690850004732	active site 2 [active]
690850004733	Domain of unknown function (DUF389); Region: DUF389; cl00781
690850004734	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
690850004735	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
690850004736	active site
690850004737	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
690850004738	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
690850004739	NAD binding site [chemical binding]; other site
690850004740	catalytic Zn binding site [ion binding]; other site
690850004741	structural Zn binding site [ion binding]; other site
690850004742	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
690850004743	putative hydrophobic ligand binding site [chemical binding]; other site
690850004744	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
690850004745	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
690850004746	NusB family; Region: NusB; pfam01029
690850004747	putative RNA binding site [nucleotide binding]; other site
690850004748	16S rRNA methyltransferase B; Provisional; Region: PRK14901
690850004749	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
690850004750	Protein of unknown function DUF116; Region: DUF116; pfam01976
690850004751	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
690850004752	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
690850004753	putative active site [active]
690850004754	substrate binding site [chemical binding]; other site
690850004755	putative cosubstrate binding site; other site
690850004756	catalytic site [active]
690850004757	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
690850004758	substrate binding site [chemical binding]; other site
690850004759	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
690850004760	active site
690850004761	catalytic residues [active]
690850004762	metal binding site [ion binding]; metal-binding site
690850004763	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
690850004764	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
690850004765	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
690850004766	Membrane protein of unknown function; Region: DUF360; pfam04020
690850004767	Proline dehydrogenase; Region: Pro_dh; cl03282
690850004768	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
690850004769	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
690850004770	Glutamate binding site [chemical binding]; other site
690850004771	homodimer interface [polypeptide binding]; other site
690850004772	NAD binding site [chemical binding]; other site
690850004773	catalytic residues [active]
690850004774	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
690850004775	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
690850004776	putative DNA binding site [nucleotide binding]; other site
690850004777	putative Zn2+ binding site [ion binding]; other site
690850004778	AsnC family; Region: AsnC_trans_reg; pfam01037
690850004779	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
690850004780	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
690850004781	HlyD family secretion protein; Region: HlyD_3; pfam13437
690850004782	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
690850004783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
690850004784	putative substrate translocation pore; other site
690850004785	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
690850004786	Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357
690850004787	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
690850004788	putative DNA binding site [nucleotide binding]; other site
690850004789	putative Zn2+ binding site [ion binding]; other site
690850004790	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
690850004791	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
690850004792	phosphoserine phosphatase SerB; Region: serB; TIGR00338
690850004793	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
690850004794	motif II; other site
690850004795	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
690850004796	putative FMN binding site [chemical binding]; other site
690850004797	NADPH bind site [chemical binding]; other site
690850004798	Domain of unknown function DUF20; Region: UPF0118; pfam01594
690850004799	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
690850004800	Staphylococcal nuclease homologues; Region: SNc; smart00318
690850004801	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
690850004802	Catalytic site; other site
690850004803	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
690850004804	dinuclear metal binding motif [ion binding]; other site
690850004805	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056
690850004806	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
690850004807	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
690850004808	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
690850004809	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
690850004810	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
690850004811	dimer interface [polypeptide binding]; other site
690850004812	PYR/PP interface [polypeptide binding]; other site
690850004813	TPP binding site [chemical binding]; other site
690850004814	substrate binding site [chemical binding]; other site
690850004815	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
690850004816	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
690850004817	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
690850004818	TPP-binding site [chemical binding]; other site
690850004819	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
690850004820	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
690850004821	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
690850004822	catalytic residues [active]
690850004823	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
690850004824	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
690850004825	dimer interface [polypeptide binding]; other site
690850004826	catalytic triad [active]
690850004827	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133
690850004828	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
690850004829	Uncharacterized conserved protein [Function unknown]; Region: COG0432
690850004830	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
690850004831	PAS domain; Region: PAS_9; pfam13426
690850004832	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850004833	putative active site [active]
690850004834	heme pocket [chemical binding]; other site
690850004835	PAS domain S-box; Region: sensory_box; TIGR00229
690850004836	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850004837	putative active site [active]
690850004838	heme pocket [chemical binding]; other site
690850004839	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850004840	PAS domain; Region: PAS_9; pfam13426
690850004841	putative active site [active]
690850004842	heme pocket [chemical binding]; other site
690850004843	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
690850004844	Histidine kinase; Region: HisKA_2; pfam07568
690850004845	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850004846	ATP binding site [chemical binding]; other site
690850004847	Mg2+ binding site [ion binding]; other site
690850004848	G-X-G motif; other site
690850004849	Predicted transcriptional regulator [Transcription]; Region: COG1959
690850004850	Transcriptional regulator; Region: Rrf2; cl17282
690850004851	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
690850004852	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
690850004853	active site
690850004854	nucleotide binding site [chemical binding]; other site
690850004855	HIGH motif; other site
690850004856	KMSKS motif; other site
690850004857	Flagellin N-methylase; Region: FliB; pfam03692
690850004858	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
690850004859	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
690850004860	Nitrogen regulatory protein P-II; Region: P-II; smart00938
690850004861	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850004862	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850004863	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
690850004864	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850004865	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
690850004866	metal binding triad; other site
690850004867	[Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693
690850004868	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
690850004869	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503
690850004870	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
690850004871	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
690850004872	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
690850004873	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
690850004874	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
690850004875	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
690850004876	Walker A/P-loop; other site
690850004877	ATP binding site [chemical binding]; other site
690850004878	Q-loop/lid; other site
690850004879	ABC transporter signature motif; other site
690850004880	Walker B; other site
690850004881	D-loop; other site
690850004882	H-loop/switch region; other site
690850004883	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
690850004884	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850004885	dimer interface [polypeptide binding]; other site
690850004886	conserved gate region; other site
690850004887	putative PBP binding loops; other site
690850004888	ABC-ATPase subunit interface; other site
690850004889	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
690850004890	AMIN domain; Region: AMIN; pfam11741
690850004891	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
690850004892	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
690850004893	active site
690850004894	metal binding site [ion binding]; metal-binding site
690850004895	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
690850004896	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
690850004897	glutaminase active site [active]
690850004898	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
690850004899	dimer interface [polypeptide binding]; other site
690850004900	active site
690850004901	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
690850004902	dimer interface [polypeptide binding]; other site
690850004903	active site
690850004904	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
690850004905	active site
690850004906	dimerization interface [polypeptide binding]; other site
690850004907	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
690850004908	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
690850004909	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850004910	FeS/SAM binding site; other site
690850004911	TRAM domain; Region: TRAM; cl01282
690850004912	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
690850004913	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
690850004914	RNA binding site [nucleotide binding]; other site
690850004915	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
690850004916	RNA binding site [nucleotide binding]; other site
690850004917	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
690850004918	RNA binding site [nucleotide binding]; other site
690850004919	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
690850004920	RNA binding site [nucleotide binding]; other site
690850004921	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
690850004922	RNA binding site [nucleotide binding]; other site
690850004923	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
690850004924	RNA binding site [nucleotide binding]; other site
690850004925	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
690850004926	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
690850004927	tandem repeat interface [polypeptide binding]; other site
690850004928	oligomer interface [polypeptide binding]; other site
690850004929	active site residues [active]
690850004930	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
690850004931	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
690850004932	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
690850004933	DNA binding site [nucleotide binding]
690850004934	active site
690850004935	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
690850004936	rod shape-determining protein MreB; Provisional; Region: PRK13927
690850004937	MreB and similar proteins; Region: MreB_like; cd10225
690850004938	nucleotide binding site [chemical binding]; other site
690850004939	Mg binding site [ion binding]; other site
690850004940	putative protofilament interaction site [polypeptide binding]; other site
690850004941	RodZ interaction site [polypeptide binding]; other site
690850004942	rod shape-determining protein MreC; Provisional; Region: PRK13922
690850004943	rod shape-determining protein MreC; Region: MreC; pfam04085
690850004944	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
690850004945	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
690850004946	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
690850004947	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
690850004948	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
690850004949	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
690850004950	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
690850004951	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
690850004952	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
690850004953	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
690850004954	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
690850004955	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
690850004956	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
690850004957	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
690850004958	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
690850004959	beta subunit interaction interface [polypeptide binding]; other site
690850004960	Walker A motif; other site
690850004961	ATP binding site [chemical binding]; other site
690850004962	Walker B motif; other site
690850004963	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
690850004964	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
690850004965	core domain interface [polypeptide binding]; other site
690850004966	delta subunit interface [polypeptide binding]; other site
690850004967	epsilon subunit interface [polypeptide binding]; other site
690850004968	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
690850004969	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
690850004970	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
690850004971	alpha subunit interaction interface [polypeptide binding]; other site
690850004972	Walker A motif; other site
690850004973	ATP binding site [chemical binding]; other site
690850004974	Walker B motif; other site
690850004975	inhibitor binding site; inhibition site
690850004976	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
690850004977	ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216
690850004978	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
690850004979	gamma subunit interface [polypeptide binding]; other site
690850004980	epsilon subunit interface [polypeptide binding]; other site
690850004981	LBP interface [polypeptide binding]; other site
690850004982	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14356
690850004983	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
690850004984	Substrate binding site; other site
690850004985	Mg++ binding site; other site
690850004986	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
690850004987	active site
690850004988	substrate binding site [chemical binding]; other site
690850004989	CoA binding site [chemical binding]; other site
690850004990	phosphodiesterase; Provisional; Region: PRK12704
690850004991	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850004992	Zn2+ binding site [ion binding]; other site
690850004993	Mg2+ binding site [ion binding]; other site
690850004994	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
690850004995	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
690850004996	active site
690850004997	putative transporter; Provisional; Region: PRK11660
690850004998	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
690850004999	Sulfate transporter family; Region: Sulfate_transp; pfam00916
690850005000	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
690850005001	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
690850005002	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
690850005003	putative active site [active]
690850005004	metal binding site [ion binding]; metal-binding site
690850005005	homodimer binding site [polypeptide binding]; other site
690850005006	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
690850005007	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
690850005008	active site
690850005009	HIGH motif; other site
690850005010	dimer interface [polypeptide binding]; other site
690850005011	KMSKS motif; other site
690850005012	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
690850005013	RNA binding surface [nucleotide binding]; other site
690850005014	Protein of unknown function, DUF606; Region: DUF606; pfam04657
690850005015	putative 4-hydroxybenzoate polyprenyltransferase; Region: ubiA_other; TIGR01475
690850005016	UbiA prenyltransferase family; Region: UbiA; pfam01040
690850005017	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
690850005018	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850005019	S-adenosylmethionine binding site [chemical binding]; other site
690850005020	Predicted methyltransferases [General function prediction only]; Region: COG0313
690850005021	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
690850005022	putative SAM binding site [chemical binding]; other site
690850005023	putative homodimer interface [polypeptide binding]; other site
690850005024	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
690850005025	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
690850005026	regulatory protein interface [polypeptide binding]; other site
690850005027	active site
690850005028	regulatory phosphorylation site [posttranslational modification]; other site
690850005029	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
690850005030	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
690850005031	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
690850005032	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
690850005033	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
690850005034	SmpB-tmRNA interface; other site
690850005035	FAD binding domain; Region: FAD_binding_4; pfam01565
690850005036	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
690850005037	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850005038	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
690850005039	Cysteine-rich domain; Region: CCG; pfam02754
690850005040	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
690850005041	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
690850005042	ATP binding site [chemical binding]; other site
690850005043	putative Mg++ binding site [ion binding]; other site
690850005044	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
690850005045	Ion channel; Region: Ion_trans_2; pfam07885
690850005046	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
690850005047	TrkA-N domain; Region: TrkA_N; pfam02254
690850005048	TrkA-C domain; Region: TrkA_C; pfam02080
690850005049	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
690850005050	TrkA-N domain; Region: TrkA_N; pfam02254
690850005051	TrkA-C domain; Region: TrkA_C; pfam02080
690850005052	FOG: CBS domain [General function prediction only]; Region: COG0517
690850005053	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
690850005054	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
690850005055	Protein of unknown function DUF111; Region: DUF111; cl03398
690850005056	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
690850005057	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
690850005058	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
690850005059	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
690850005060	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
690850005061	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
690850005062	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
690850005063	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668
690850005064	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
690850005065	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
690850005066	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
690850005067	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
690850005068	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
690850005069	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
690850005070	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
690850005071	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
690850005072	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
690850005073	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
690850005074	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
690850005075	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
690850005076	NADH dehydrogenase subunit B; Validated; Region: PRK06411
690850005077	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
690850005078	thiosulfate reductase PhsA; Provisional; Region: PRK15488
690850005079	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
690850005080	putative [Fe4-S4] binding site [ion binding]; other site
690850005081	putative molybdopterin cofactor binding site [chemical binding]; other site
690850005082	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
690850005083	putative molybdopterin cofactor binding site; other site
690850005084	Putative heavy-metal-binding; Region: YbjQ_1; pfam01906
690850005085	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
690850005086	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
690850005087	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
690850005088	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
690850005089	active site
690850005090	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850005091	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850005092	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
690850005093	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
690850005094	active site
690850005095	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
690850005096	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
690850005097	putative dimer interface [polypeptide binding]; other site
690850005098	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
690850005099	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
690850005100	putative dimer interface [polypeptide binding]; other site
690850005101	Uncharacterized conserved protein [Function unknown]; Region: COG2835
690850005102	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
690850005103	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
690850005104	active site
690850005105	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
690850005106	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
690850005107	Peptidase family U32; Region: Peptidase_U32; pfam01136
690850005108	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
690850005109	PAS domain; Region: PAS; smart00091
690850005110	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850005111	ATP binding site [chemical binding]; other site
690850005112	Mg2+ binding site [ion binding]; other site
690850005113	G-X-G motif; other site
690850005114	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
690850005115	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
690850005116	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
690850005117	Response regulator receiver domain; Region: Response_reg; pfam00072
690850005118	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850005119	active site
690850005120	phosphorylation site [posttranslational modification]
690850005121	intermolecular recognition site; other site
690850005122	dimerization interface [polypeptide binding]; other site
690850005123	PAS domain; Region: PAS_9; pfam13426
690850005124	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850005125	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850005126	metal binding site [ion binding]; metal-binding site
690850005127	active site
690850005128	I-site; other site
690850005129	Response regulator receiver domain; Region: Response_reg; pfam00072
690850005130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850005131	active site
690850005132	phosphorylation site [posttranslational modification]
690850005133	intermolecular recognition site; other site
690850005134	dimerization interface [polypeptide binding]; other site
690850005135	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005136	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850005137	putative active site [active]
690850005138	heme pocket [chemical binding]; other site
690850005139	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850005140	dimer interface [polypeptide binding]; other site
690850005141	phosphorylation site [posttranslational modification]
690850005142	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850005143	ATP binding site [chemical binding]; other site
690850005144	Mg2+ binding site [ion binding]; other site
690850005145	G-X-G motif; other site
690850005146	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850005147	metal binding site [ion binding]; metal-binding site
690850005148	active site
690850005149	I-site; other site
690850005150	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
690850005151	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
690850005152	putative ligand binding site [chemical binding]; other site
690850005153	putative NAD binding site [chemical binding]; other site
690850005154	catalytic site [active]
690850005155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850005156	Response regulator receiver domain; Region: Response_reg; pfam00072
690850005157	active site
690850005158	phosphorylation site [posttranslational modification]
690850005159	intermolecular recognition site; other site
690850005160	dimerization interface [polypeptide binding]; other site
690850005161	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
690850005162	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
690850005163	putative acyl-acceptor binding pocket; other site
690850005164	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
690850005165	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
690850005166	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
690850005167	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
690850005168	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
690850005169	Mechanosensitive ion channel; Region: MS_channel; pfam00924
690850005170	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
690850005171	Mechanosensitive ion channel; Region: MS_channel; pfam00924
690850005172	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
690850005173	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
690850005174	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005175	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850005176	putative active site [active]
690850005177	heme pocket [chemical binding]; other site
690850005178	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005179	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850005180	putative active site [active]
690850005181	heme pocket [chemical binding]; other site
690850005182	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005183	putative active site [active]
690850005184	heme pocket [chemical binding]; other site
690850005185	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850005186	dimer interface [polypeptide binding]; other site
690850005187	phosphorylation site [posttranslational modification]
690850005188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850005189	ATP binding site [chemical binding]; other site
690850005190	Mg2+ binding site [ion binding]; other site
690850005191	G-X-G motif; other site
690850005192	Response regulator receiver domain; Region: Response_reg; pfam00072
690850005193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850005194	active site
690850005195	phosphorylation site [posttranslational modification]
690850005196	intermolecular recognition site; other site
690850005197	dimerization interface [polypeptide binding]; other site
690850005198	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
690850005199	metal binding site 2 [ion binding]; metal-binding site
690850005200	putative DNA binding helix; other site
690850005201	metal binding site 1 [ion binding]; metal-binding site
690850005202	dimer interface [polypeptide binding]; other site
690850005203	structural Zn2+ binding site [ion binding]; other site
690850005204	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
690850005205	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
690850005206	putative metal binding residues [ion binding]; other site
690850005207	Predicted permease; Region: DUF318; cl17795
690850005208	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
690850005209	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
690850005210	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
690850005211	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
690850005212	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
690850005213	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
690850005214	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
690850005215	B12 binding site [chemical binding]; other site
690850005216	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
690850005217	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
690850005218	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
690850005219	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
690850005220	active site
690850005221	Zn binding site [ion binding]; other site
690850005222	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
690850005223	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
690850005224	Walker A/P-loop; other site
690850005225	ATP binding site [chemical binding]; other site
690850005226	Q-loop/lid; other site
690850005227	ABC transporter signature motif; other site
690850005228	Walker B; other site
690850005229	D-loop; other site
690850005230	H-loop/switch region; other site
690850005231	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
690850005232	FtsX-like permease family; Region: FtsX; pfam02687
690850005233	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
690850005234	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
690850005235	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
690850005236	Ligand binding site; other site
690850005237	DXD motif; other site
690850005238	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
690850005239	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
690850005240	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
690850005241	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
690850005242	PAS domain S-box; Region: sensory_box; TIGR00229
690850005243	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005244	putative active site [active]
690850005245	heme pocket [chemical binding]; other site
690850005246	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
690850005247	Histidine kinase; Region: HisKA_2; pfam07568
690850005248	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850005249	ATP binding site [chemical binding]; other site
690850005250	Mg2+ binding site [ion binding]; other site
690850005251	G-X-G motif; other site
690850005252	Domain of unknown function DUF20; Region: UPF0118; pfam01594
690850005253	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
690850005254	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
690850005255	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
690850005256	ApbE family; Region: ApbE; pfam02424
690850005257	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
690850005258	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
690850005259	Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581
690850005260	Iron-sulfur protein interface; other site
690850005261	proximal heme binding site [chemical binding]; other site
690850005262	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
690850005263	distal heme binding site [chemical binding]; other site
690850005264	dimer interface [polypeptide binding]; other site
690850005265	fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626
690850005266	L-aspartate oxidase; Provisional; Region: PRK06175
690850005267	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
690850005268	fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552
690850005269	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
690850005270	fumarate hydratase; Provisional; Region: PRK06246
690850005271	Fumarase C-terminus; Region: Fumerase_C; cl00795
690850005272	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
690850005273	Malic enzyme, N-terminal domain; Region: malic; pfam00390
690850005274	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
690850005275	putative NAD(P) binding site [chemical binding]; other site
690850005276	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
690850005277	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
690850005278	transmembrane helices; other site
690850005279	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
690850005280	heme-binding residues [chemical binding]; other site
690850005281	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
690850005282	heme-binding residues [chemical binding]; other site
690850005283	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
690850005284	heme-binding residues [chemical binding]; other site
690850005285	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
690850005286	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850005287	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
690850005288	FMN-binding domain; Region: FMN_bind; cl01081
690850005289	electron transport complex RsxE subunit; Provisional; Region: PRK12405
690850005290	electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943
690850005291	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
690850005292	4Fe-4S binding domain; Region: Fer4; pfam00037
690850005293	putative oxidoreductase; Provisional; Region: PRK12831
690850005294	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
690850005295	rod shape-determining protein MreB; Provisional; Region: PRK13930
690850005296	MreB and similar proteins; Region: MreB_like; cd10225
690850005297	nucleotide binding site [chemical binding]; other site
690850005298	Mg binding site [ion binding]; other site
690850005299	putative protofilament interaction site [polypeptide binding]; other site
690850005300	RodZ interaction site [polypeptide binding]; other site
690850005301	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
690850005302	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
690850005303	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850005304	dimer interface [polypeptide binding]; other site
690850005305	phosphorylation site [posttranslational modification]
690850005306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850005307	ATP binding site [chemical binding]; other site
690850005308	Mg2+ binding site [ion binding]; other site
690850005309	G-X-G motif; other site
690850005310	Response regulator receiver domain; Region: Response_reg; pfam00072
690850005311	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850005312	active site
690850005313	phosphorylation site [posttranslational modification]
690850005314	intermolecular recognition site; other site
690850005315	dimerization interface [polypeptide binding]; other site
690850005316	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
690850005317	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
690850005318	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
690850005319	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
690850005320	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
690850005321	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
690850005322	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
690850005323	Walker A/P-loop; other site
690850005324	ATP binding site [chemical binding]; other site
690850005325	Q-loop/lid; other site
690850005326	ABC transporter signature motif; other site
690850005327	Walker B; other site
690850005328	D-loop; other site
690850005329	H-loop/switch region; other site
690850005330	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
690850005331	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
690850005332	ABC-ATPase subunit  interface; other site
690850005333	dimer interface [polypeptide binding]; other site
690850005334	putative PBP binding regions; other site
690850005335	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
690850005336	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
690850005337	putative metal binding site [ion binding]; other site
690850005338	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850005339	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
690850005340	Walker A/P-loop; other site
690850005341	ATP binding site [chemical binding]; other site
690850005342	Q-loop/lid; other site
690850005343	ABC transporter signature motif; other site
690850005344	Walker B; other site
690850005345	D-loop; other site
690850005346	H-loop/switch region; other site
690850005347	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850005348	Walker A/P-loop; other site
690850005349	ATP binding site [chemical binding]; other site
690850005350	Q-loop/lid; other site
690850005351	ABC transporter signature motif; other site
690850005352	Walker B; other site
690850005353	D-loop; other site
690850005354	H-loop/switch region; other site
690850005355	GAF domain; Region: GAF_3; pfam13492
690850005356	PAS domain S-box; Region: sensory_box; TIGR00229
690850005357	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005358	putative active site [active]
690850005359	heme pocket [chemical binding]; other site
690850005360	PAS domain S-box; Region: sensory_box; TIGR00229
690850005361	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005362	putative active site [active]
690850005363	heme pocket [chemical binding]; other site
690850005364	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850005365	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850005366	metal binding site [ion binding]; metal-binding site
690850005367	active site
690850005368	I-site; other site
690850005369	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
690850005370	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
690850005371	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
690850005372	ATP binding site [chemical binding]; other site
690850005373	substrate interface [chemical binding]; other site
690850005374	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
690850005375	MoaE interaction surface [polypeptide binding]; other site
690850005376	MoeB interaction surface [polypeptide binding]; other site
690850005377	thiocarboxylated glycine; other site
690850005378	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790
690850005379	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
690850005380	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
690850005381	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
690850005382	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
690850005383	active site
690850005384	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
690850005385	non-specific DNA binding site [nucleotide binding]; other site
690850005386	salt bridge; other site
690850005387	sequence-specific DNA binding site [nucleotide binding]; other site
690850005388	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
690850005389	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850005390	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850005391	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850005392	malate synthase G; Provisional; Region: PRK02999
690850005393	active site
690850005394	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
690850005395	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
690850005396	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850005397	FeS/SAM binding site; other site
690850005398	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
690850005399	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850005400	FeS/SAM binding site; other site
690850005401	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
690850005402	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
690850005403	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
690850005404	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
690850005405	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
690850005406	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
690850005407	putative dimerization interface [polypeptide binding]; other site
690850005408	CHASE2 domain; Region: CHASE2; pfam05226
690850005409	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
690850005410	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850005411	Zn2+ binding site [ion binding]; other site
690850005412	Mg2+ binding site [ion binding]; other site
690850005413	FecR protein; Region: FecR; pfam04773
690850005414	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
690850005415	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
690850005416	Walker A/P-loop; other site
690850005417	ATP binding site [chemical binding]; other site
690850005418	Q-loop/lid; other site
690850005419	ABC transporter signature motif; other site
690850005420	Walker B; other site
690850005421	D-loop; other site
690850005422	H-loop/switch region; other site
690850005423	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
690850005424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850005425	dimer interface [polypeptide binding]; other site
690850005426	conserved gate region; other site
690850005427	putative PBP binding loops; other site
690850005428	ABC-ATPase subunit interface; other site
690850005429	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
690850005430	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
690850005431	substrate binding pocket [chemical binding]; other site
690850005432	membrane-bound complex binding site; other site
690850005433	hinge residues; other site
690850005434	Putative exonuclease, RdgC; Region: RdgC; cl01122
690850005435	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850005436	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850005437	active site
690850005438	phosphorylation site [posttranslational modification]
690850005439	intermolecular recognition site; other site
690850005440	dimerization interface [polypeptide binding]; other site
690850005441	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
690850005442	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
690850005443	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188
690850005444	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
690850005445	putative active site [active]
690850005446	metal binding site [ion binding]; metal-binding site
690850005447	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850005448	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005449	putative active site [active]
690850005450	heme pocket [chemical binding]; other site
690850005451	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850005452	dimer interface [polypeptide binding]; other site
690850005453	phosphorylation site [posttranslational modification]
690850005454	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850005455	ATP binding site [chemical binding]; other site
690850005456	Mg2+ binding site [ion binding]; other site
690850005457	G-X-G motif; other site
690850005458	Response regulator receiver domain; Region: Response_reg; pfam00072
690850005459	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850005460	active site
690850005461	phosphorylation site [posttranslational modification]
690850005462	intermolecular recognition site; other site
690850005463	dimerization interface [polypeptide binding]; other site
690850005464	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
690850005465	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
690850005466	Walker A/P-loop; other site
690850005467	ATP binding site [chemical binding]; other site
690850005468	Q-loop/lid; other site
690850005469	ABC transporter signature motif; other site
690850005470	Walker B; other site
690850005471	D-loop; other site
690850005472	H-loop/switch region; other site
690850005473	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
690850005474	active site
690850005475	catalytic triad [active]
690850005476	oxyanion hole [active]
690850005477	switch loop; other site
690850005478	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
690850005479	dimer interface [polypeptide binding]; other site
690850005480	catalytic triad [active]
690850005481	peroxidatic and resolving cysteines [active]
690850005482	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850005483	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850005484	active site
690850005485	phosphorylation site [posttranslational modification]
690850005486	intermolecular recognition site; other site
690850005487	dimerization interface [polypeptide binding]; other site
690850005488	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850005489	dimer interface [polypeptide binding]; other site
690850005490	phosphorylation site [posttranslational modification]
690850005491	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850005492	ATP binding site [chemical binding]; other site
690850005493	Mg2+ binding site [ion binding]; other site
690850005494	G-X-G motif; other site
690850005495	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
690850005496	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
690850005497	non-specific DNA binding site [nucleotide binding]; other site
690850005498	salt bridge; other site
690850005499	Predicted transcriptional regulator [Transcription]; Region: COG2932
690850005500	sequence-specific DNA binding site [nucleotide binding]; other site
690850005501	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
690850005502	Catalytic site [active]
690850005503	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
690850005504	Predicted membrane protein [Function unknown]; Region: COG4325
690850005505	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
690850005506	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
690850005507	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
690850005508	FtsH Extracellular; Region: FtsH_ext; pfam06480
690850005509	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
690850005510	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850005511	Walker A motif; other site
690850005512	ATP binding site [chemical binding]; other site
690850005513	Walker B motif; other site
690850005514	arginine finger; other site
690850005515	Peptidase family M41; Region: Peptidase_M41; pfam01434
690850005516	Outer membrane lipoprotein Slp family; Region: Slp; pfam03843
690850005517	aspartate aminotransferase; Provisional; Region: PRK06836
690850005518	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
690850005519	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850005520	homodimer interface [polypeptide binding]; other site
690850005521	catalytic residue [active]
690850005522	PemK-like protein; Region: PemK; pfam02452
690850005523	metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921
690850005524	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
690850005525	Flavodoxin; Region: Flavodoxin_1; pfam00258
690850005526	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
690850005527	Rubredoxin; Region: Rubredoxin; pfam00301
690850005528	iron binding site [ion binding]; other site
690850005529	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
690850005530	Rubredoxin; Region: Rubredoxin; pfam00301
690850005531	iron binding site [ion binding]; other site
690850005532	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
690850005533	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
690850005534	Tim44-like domain; Region: Tim44; pfam04280
690850005535	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
690850005536	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
690850005537	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
690850005538	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
690850005539	dimerization interface [polypeptide binding]; other site
690850005540	ATP binding site [chemical binding]; other site
690850005541	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
690850005542	dimerization interface [polypeptide binding]; other site
690850005543	ATP binding site [chemical binding]; other site
690850005544	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
690850005545	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
690850005546	substrate binding pocket [chemical binding]; other site
690850005547	chain length determination region; other site
690850005548	substrate-Mg2+ binding site; other site
690850005549	catalytic residues [active]
690850005550	aspartate-rich region 1; other site
690850005551	active site lid residues [active]
690850005552	aspartate-rich region 2; other site
690850005553	futalosine nucleosidase; Region: fut_nucase; TIGR03664
690850005554	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275
690850005555	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
690850005556	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850005557	S-adenosylmethionine binding site [chemical binding]; other site
690850005558	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
690850005559	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
690850005560	heme-binding residues [chemical binding]; other site
690850005561	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
690850005562	active site
690850005563	SAM binding site [chemical binding]; other site
690850005564	homodimer interface [polypeptide binding]; other site
690850005565	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
690850005566	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
690850005567	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
690850005568	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
690850005569	Domain of unknown function DUF21; Region: DUF21; pfam01595
690850005570	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
690850005571	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
690850005572	Transporter associated domain; Region: CorC_HlyC; smart01091
690850005573	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
690850005574	HlyD family secretion protein; Region: HlyD_3; pfam13437
690850005575	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
690850005576	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
690850005577	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
690850005578	inhibitor-cofactor binding pocket; inhibition site
690850005579	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850005580	catalytic residue [active]
690850005581	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
690850005582	Protein of unknown function (DUF2805); Region: DUF2805; cl11923
690850005583	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
690850005584	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
690850005585	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
690850005586	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850005587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850005588	active site
690850005589	phosphorylation site [posttranslational modification]
690850005590	intermolecular recognition site; other site
690850005591	dimerization interface [polypeptide binding]; other site
690850005592	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850005593	binding surface
690850005594	TPR motif; other site
690850005595	TPR repeat; Region: TPR_11; pfam13414
690850005596	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850005597	binding surface
690850005598	TPR motif; other site
690850005599	Putative integral membrane protein DUF46; Region: DUF46; cl17511
690850005600	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
690850005601	putative active site [active]
690850005602	putative metal binding site [ion binding]; other site
690850005603	CHASE4 domain; Region: CHASE4; cl01308
690850005604	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
690850005605	PAS fold; Region: PAS_4; pfam08448
690850005606	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850005607	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850005608	dimer interface [polypeptide binding]; other site
690850005609	putative CheW interface [polypeptide binding]; other site
690850005610	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
690850005611	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
690850005612	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
690850005613	ligand binding site [chemical binding]; other site
690850005614	flexible hinge region; other site
690850005615	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
690850005616	putative switch regulator; other site
690850005617	non-specific DNA interactions [nucleotide binding]; other site
690850005618	DNA binding site [nucleotide binding]
690850005619	sequence specific DNA binding site [nucleotide binding]; other site
690850005620	putative cAMP binding site [chemical binding]; other site
690850005621	Rubrerythrin [Energy production and conversion]; Region: COG1592
690850005622	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
690850005623	binuclear metal center [ion binding]; other site
690850005624	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
690850005625	iron binding site [ion binding]; other site
690850005626	Domain of unknown function (DUF1127); Region: DUF1127; cl02276
690850005627	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
690850005628	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
690850005629	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
690850005630	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
690850005631	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
690850005632	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
690850005633	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850005634	Walker A/P-loop; other site
690850005635	ATP binding site [chemical binding]; other site
690850005636	Q-loop/lid; other site
690850005637	ABC transporter signature motif; other site
690850005638	Walker B; other site
690850005639	D-loop; other site
690850005640	H-loop/switch region; other site
690850005641	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
690850005642	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
690850005643	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
690850005644	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850005645	putative PBP binding loops; other site
690850005646	dimer interface [polypeptide binding]; other site
690850005647	ABC-ATPase subunit interface; other site
690850005648	PAS fold; Region: PAS_4; pfam08448
690850005649	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005650	putative active site [active]
690850005651	heme pocket [chemical binding]; other site
690850005652	PAS domain; Region: PAS_9; pfam13426
690850005653	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005654	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850005655	putative active site [active]
690850005656	heme pocket [chemical binding]; other site
690850005657	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850005658	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005659	putative active site [active]
690850005660	heme pocket [chemical binding]; other site
690850005661	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850005662	dimer interface [polypeptide binding]; other site
690850005663	phosphorylation site [posttranslational modification]
690850005664	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850005665	ATP binding site [chemical binding]; other site
690850005666	Mg2+ binding site [ion binding]; other site
690850005667	G-X-G motif; other site
690850005668	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850005669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850005670	active site
690850005671	phosphorylation site [posttranslational modification]
690850005672	intermolecular recognition site; other site
690850005673	dimerization interface [polypeptide binding]; other site
690850005674	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
690850005675	PBP superfamily domain; Region: PBP_like_2; pfam12849
690850005676	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
690850005677	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
690850005678	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
690850005679	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
690850005680	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
690850005681	GTP binding site; other site
690850005682	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
690850005683	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850005684	FeS/SAM binding site; other site
690850005685	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
690850005686	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
690850005687	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
690850005688	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
690850005689	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
690850005690	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
690850005691	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
690850005692	[4Fe-4S] binding site [ion binding]; other site
690850005693	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
690850005694	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
690850005695	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
690850005696	molybdopterin cofactor binding site; other site
690850005697	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
690850005698	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
690850005699	FAD binding domain; Region: FAD_binding_4; pfam01565
690850005700	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
690850005701	putative oxidoreductase; Provisional; Region: PRK12831
690850005702	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850005703	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
690850005704	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
690850005705	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
690850005706	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
690850005707	FAD binding pocket [chemical binding]; other site
690850005708	FAD binding motif [chemical binding]; other site
690850005709	phosphate binding motif [ion binding]; other site
690850005710	beta-alpha-beta structure motif; other site
690850005711	NAD binding pocket [chemical binding]; other site
690850005712	Iron coordination center [ion binding]; other site
690850005713	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
690850005714	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
690850005715	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
690850005716	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
690850005717	Predicted transcriptional regulator [Transcription]; Region: COG3655
690850005718	salt bridge; other site
690850005719	non-specific DNA binding site [nucleotide binding]; other site
690850005720	sequence-specific DNA binding site [nucleotide binding]; other site
690850005721	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
690850005722	phosphate binding site [ion binding]; other site
690850005723	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
690850005724	Histidine kinase; Region: HisKA_3; pfam07730
690850005725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850005726	ATP binding site [chemical binding]; other site
690850005727	Mg2+ binding site [ion binding]; other site
690850005728	G-X-G motif; other site
690850005729	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
690850005730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850005731	active site
690850005732	phosphorylation site [posttranslational modification]
690850005733	intermolecular recognition site; other site
690850005734	dimerization interface [polypeptide binding]; other site
690850005735	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
690850005736	DNA binding residues [nucleotide binding]
690850005737	dimerization interface [polypeptide binding]; other site
690850005738	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
690850005739	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
690850005740	active site residue [active]
690850005741	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
690850005742	active site residue [active]
690850005743	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
690850005744	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
690850005745	dimer interface [polypeptide binding]; other site
690850005746	decamer (pentamer of dimers) interface [polypeptide binding]; other site
690850005747	catalytic triad [active]
690850005748	peroxidatic and resolving cysteines [active]
690850005749	Rubredoxin [Energy production and conversion]; Region: COG1773
690850005750	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
690850005751	iron binding site [ion binding]; other site
690850005752	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
690850005753	CoenzymeA binding site [chemical binding]; other site
690850005754	subunit interaction site [polypeptide binding]; other site
690850005755	PHB binding site; other site
690850005756	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
690850005757	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
690850005758	CGGC domain; Region: CGGC; cl02356
690850005759	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
690850005760	trimerization site [polypeptide binding]; other site
690850005761	active site
690850005762	Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834
690850005763	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
690850005764	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
690850005765	Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579
690850005766	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005767	PAS domain; Region: PAS_9; pfam13426
690850005768	putative active site [active]
690850005769	heme pocket [chemical binding]; other site
690850005770	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
690850005771	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850005772	Walker A motif; other site
690850005773	ATP binding site [chemical binding]; other site
690850005774	Walker B motif; other site
690850005775	arginine finger; other site
690850005776	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850005777	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
690850005778	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
690850005779	P loop nucleotide binding; other site
690850005780	switch II; other site
690850005781	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
690850005782	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
690850005783	P loop nucleotide binding; other site
690850005784	switch II; other site
690850005785	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
690850005786	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005787	PAS domain; Region: PAS_9; pfam13426
690850005788	putative active site [active]
690850005789	heme pocket [chemical binding]; other site
690850005790	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
690850005791	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850005792	Walker B motif; other site
690850005793	arginine finger; other site
690850005794	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850005795	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
690850005796	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
690850005797	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
690850005798	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
690850005799	catalytic triad [active]
690850005800	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005801	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850005802	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850005803	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005804	putative active site [active]
690850005805	heme pocket [chemical binding]; other site
690850005806	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850005807	dimer interface [polypeptide binding]; other site
690850005808	phosphorylation site [posttranslational modification]
690850005809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850005810	ATP binding site [chemical binding]; other site
690850005811	Mg2+ binding site [ion binding]; other site
690850005812	G-X-G motif; other site
690850005813	Response regulator receiver domain; Region: Response_reg; pfam00072
690850005814	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850005815	active site
690850005816	phosphorylation site [posttranslational modification]
690850005817	intermolecular recognition site; other site
690850005818	dimerization interface [polypeptide binding]; other site
690850005819	AMP-binding enzyme; Region: AMP-binding; pfam00501
690850005820	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
690850005821	acyl-activating enzyme (AAE) consensus motif; other site
690850005822	AMP binding site [chemical binding]; other site
690850005823	active site
690850005824	CoA binding site [chemical binding]; other site
690850005825	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005826	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850005827	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850005828	dimer interface [polypeptide binding]; other site
690850005829	phosphorylation site [posttranslational modification]
690850005830	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850005831	ATP binding site [chemical binding]; other site
690850005832	Mg2+ binding site [ion binding]; other site
690850005833	G-X-G motif; other site
690850005834	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
690850005835	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
690850005836	Walker A motif/ATP binding site; other site
690850005837	Walker B motif; other site
690850005838	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
690850005839	Flagellar assembly protein FliH; Region: FliH; pfam02108
690850005840	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
690850005841	MgtE intracellular N domain; Region: MgtE_N; cl15244
690850005842	FliG C-terminal domain; Region: FliG_C; pfam01706
690850005843	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
690850005844	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
690850005845	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
690850005846	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
690850005847	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
690850005848	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
690850005849	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12621
690850005850	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
690850005851	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850005852	binding surface
690850005853	TPR motif; other site
690850005854	TPR repeat; Region: TPR_11; pfam13414
690850005855	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850005856	binding surface
690850005857	TPR motif; other site
690850005858	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
690850005859	purine monophosphate binding site [chemical binding]; other site
690850005860	dimer interface [polypeptide binding]; other site
690850005861	putative catalytic residues [active]
690850005862	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
690850005863	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
690850005864	HflX GTPase family; Region: HflX; cd01878
690850005865	G1 box; other site
690850005866	GTP/Mg2+ binding site [chemical binding]; other site
690850005867	Switch I region; other site
690850005868	G2 box; other site
690850005869	G3 box; other site
690850005870	Switch II region; other site
690850005871	G4 box; other site
690850005872	G5 box; other site
690850005873	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850005874	dimer interface [polypeptide binding]; other site
690850005875	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
690850005876	putative CheW interface [polypeptide binding]; other site
690850005877	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
690850005878	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
690850005879	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
690850005880	Peptidase family M50; Region: Peptidase_M50; pfam02163
690850005881	active site
690850005882	putative substrate binding region [chemical binding]; other site
690850005883	FOG: CBS domain [General function prediction only]; Region: COG0517
690850005884	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
690850005885	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
690850005886	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
690850005887	RNB domain; Region: RNB; pfam00773
690850005888	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
690850005889	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
690850005890	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
690850005891	N-acetyl-D-glucosamine binding site [chemical binding]; other site
690850005892	catalytic residue [active]
690850005893	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
690850005894	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
690850005895	GDP-binding site [chemical binding]; other site
690850005896	ACT binding site; other site
690850005897	IMP binding site; other site
690850005898	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
690850005899	Cysteine-rich domain; Region: CCG; pfam02754
690850005900	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
690850005901	Ligand Binding Site [chemical binding]; other site
690850005902	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
690850005903	Ligand Binding Site [chemical binding]; other site
690850005904	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
690850005905	Cysteine-rich domain; Region: CCG; pfam02754
690850005906	Cysteine-rich domain; Region: CCG; pfam02754
690850005907	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850005908	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
690850005909	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
690850005910	4Fe-4S binding domain; Region: Fer4; pfam00037
690850005911	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
690850005912	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
690850005913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
690850005914	active site
690850005915	phosphorylation site [posttranslational modification]
690850005916	intermolecular recognition site; other site
690850005917	dimerization interface [polypeptide binding]; other site
690850005918	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
690850005919	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
690850005920	4Fe-4S binding domain; Region: Fer4; pfam00037
690850005921	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
690850005922	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850005923	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
690850005924	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
690850005925	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
690850005926	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
690850005927	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
690850005928	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
690850005929	PAS domain; Region: PAS_9; pfam13426
690850005930	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005931	putative active site [active]
690850005932	heme pocket [chemical binding]; other site
690850005933	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
690850005934	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850005935	putative active site [active]
690850005936	heme pocket [chemical binding]; other site
690850005937	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850005938	dimer interface [polypeptide binding]; other site
690850005939	phosphorylation site [posttranslational modification]
690850005940	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850005941	ATP binding site [chemical binding]; other site
690850005942	Mg2+ binding site [ion binding]; other site
690850005943	G-X-G motif; other site
690850005944	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850005945	Response regulator receiver domain; Region: Response_reg; pfam00072
690850005946	active site
690850005947	phosphorylation site [posttranslational modification]
690850005948	intermolecular recognition site; other site
690850005949	dimerization interface [polypeptide binding]; other site
690850005950	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850005951	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850005952	active site
690850005953	phosphorylation site [posttranslational modification]
690850005954	intermolecular recognition site; other site
690850005955	dimerization interface [polypeptide binding]; other site
690850005956	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850005957	Walker A motif; other site
690850005958	ATP binding site [chemical binding]; other site
690850005959	Walker B motif; other site
690850005960	arginine finger; other site
690850005961	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
690850005962	substrate binding site [chemical binding]; other site
690850005963	active site
690850005964	catalytic residues [active]
690850005965	heterodimer interface [polypeptide binding]; other site
690850005966	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
690850005967	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
690850005968	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850005969	catalytic residue [active]
690850005970	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
690850005971	active site
690850005972	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
690850005973	active site
690850005974	ribulose/triose binding site [chemical binding]; other site
690850005975	phosphate binding site [ion binding]; other site
690850005976	substrate (anthranilate) binding pocket [chemical binding]; other site
690850005977	product (indole) binding pocket [chemical binding]; other site
690850005978	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
690850005979	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
690850005980	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
690850005981	Glutamine amidotransferase class-I; Region: GATase; pfam00117
690850005982	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
690850005983	glutamine binding [chemical binding]; other site
690850005984	catalytic triad [active]
690850005985	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
690850005986	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
690850005987	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
690850005988	prephenate dehydrogenase; Provisional; Region: PRK06444
690850005989	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
690850005990	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
690850005991	hinge; other site
690850005992	active site
690850005993	Chorismate mutase type II; Region: CM_2; pfam01817
690850005994	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
690850005995	Prephenate dehydratase; Region: PDT; pfam00800
690850005996	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
690850005997	putative L-Phe binding site [chemical binding]; other site
690850005998	Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465
690850005999	3-dehydroquinate synthase; Provisional; Region: PRK02290
690850006000	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
690850006001	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
690850006002	putative active site; other site
690850006003	catalytic residue [active]
690850006004	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
690850006005	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
690850006006	Nitrogen regulatory protein P-II; Region: P-II; smart00938
690850006007	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
690850006008	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
690850006009	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850006010	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850006011	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
690850006012	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850006013	Isochorismatase family; Region: Isochorismatase; pfam00857
690850006014	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
690850006015	catalytic triad [active]
690850006016	conserved cis-peptide bond; other site
690850006017	PilZ domain; Region: PilZ; pfam07238
690850006018	photolyase PhrII; Region: phr2; TIGR00591
690850006019	DNA photolyase; Region: DNA_photolyase; pfam00875
690850006020	HAMP domain; Region: HAMP; pfam00672
690850006021	PAS domain; Region: PAS_9; pfam13426
690850006022	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850006023	putative active site [active]
690850006024	heme pocket [chemical binding]; other site
690850006025	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850006026	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850006027	dimer interface [polypeptide binding]; other site
690850006028	putative CheW interface [polypeptide binding]; other site
690850006029	PBP superfamily domain; Region: PBP_like_2; cl17296
690850006030	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
690850006031	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850006032	dimer interface [polypeptide binding]; other site
690850006033	conserved gate region; other site
690850006034	putative PBP binding loops; other site
690850006035	ABC-ATPase subunit interface; other site
690850006036	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
690850006037	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
690850006038	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850006039	dimer interface [polypeptide binding]; other site
690850006040	conserved gate region; other site
690850006041	putative PBP binding loops; other site
690850006042	ABC-ATPase subunit interface; other site
690850006043	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
690850006044	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
690850006045	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
690850006046	active site
690850006047	putative homodimer interface [polypeptide binding]; other site
690850006048	SAM binding site [chemical binding]; other site
690850006049	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
690850006050	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850006051	S-adenosylmethionine binding site [chemical binding]; other site
690850006052	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
690850006053	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
690850006054	G1 box; other site
690850006055	putative GEF interaction site [polypeptide binding]; other site
690850006056	GTP/Mg2+ binding site [chemical binding]; other site
690850006057	Switch I region; other site
690850006058	G2 box; other site
690850006059	G3 box; other site
690850006060	Switch II region; other site
690850006061	G4 box; other site
690850006062	G5 box; other site
690850006063	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
690850006064	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
690850006065	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
690850006066	active site
690850006067	SAM binding site [chemical binding]; other site
690850006068	homodimer interface [polypeptide binding]; other site
690850006069	Hemerythrin; Region: Hemerythrin; cd12107
690850006070	Fe binding site [ion binding]; other site
690850006071	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
690850006072	dinuclear metal binding motif [ion binding]; other site
690850006073	D5 N terminal like; Region: D5_N; pfam08706
690850006074	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
690850006075	CHC2 zinc finger; Region: zf-CHC2; cl17510
690850006076	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
690850006077	putative DNA binding helix; other site
690850006078	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
690850006079	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
690850006080	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
690850006081	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
690850006082	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
690850006083	Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956
690850006084	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
690850006085	amidase catalytic site [active]
690850006086	Zn binding residues [ion binding]; other site
690850006087	substrate binding site [chemical binding]; other site
690850006088	Protein of unknown function (DUF3154); Region: DUF3154; pfam11351
690850006089	Protein of unknown function (DUF2635); Region: DUF2635; pfam10948
690850006090	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
690850006091	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
690850006092	Phage tail tube protein; Region: Tail_tube; pfam10618
690850006093	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
690850006094	Mu-like prophage protein [General function prediction only]; Region: COG3941
690850006095	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
690850006096	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
690850006097	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410
690850006098	Phage protein GP46; Region: GP46; pfam07409
690850006099	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
690850006100	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542
690850006101	Staphylococcal nuclease homologues; Region: SNc; smart00318
690850006102	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
690850006103	Catalytic site; other site
690850006104	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
690850006105	Uncharacterized conserved protein [Function unknown]; Region: COG4748
690850006106	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
690850006107	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
690850006108	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
690850006109	Catalytic site [active]
690850006110	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
690850006111	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
690850006112	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
690850006113	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
690850006114	Ligand Binding Site [chemical binding]; other site
690850006115	AAA domain; Region: AAA_33; pfam13671
690850006116	AAA domain; Region: AAA_17; cl17253
690850006117	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
690850006118	active site
690850006119	catalytic residues [active]
690850006120	DNA binding site [nucleotide binding]
690850006121	Int/Topo IB signature motif; other site
690850006122	seryl-tRNA synthetase; Provisional; Region: PRK05431
690850006123	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
690850006124	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
690850006125	dimer interface [polypeptide binding]; other site
690850006126	active site
690850006127	motif 1; other site
690850006128	motif 2; other site
690850006129	motif 3; other site
690850006130	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
690850006131	Competence-damaged protein; Region: CinA; pfam02464
690850006132	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
690850006133	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
690850006134	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
690850006135	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
690850006136	Ligand Binding Site [chemical binding]; other site
690850006137	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
690850006138	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
690850006139	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850006140	homodimer interface [polypeptide binding]; other site
690850006141	catalytic residue [active]
690850006142	cytidylate kinase; Provisional; Region: cmk; PRK00023
690850006143	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
690850006144	CMP-binding site; other site
690850006145	The sites determining sugar specificity; other site
690850006146	HDOD domain; Region: HDOD; pfam08668
690850006147	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850006148	Zn2+ binding site [ion binding]; other site
690850006149	Mg2+ binding site [ion binding]; other site
690850006150	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
690850006151	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
690850006152	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850006153	FeS/SAM binding site; other site
690850006154	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
690850006155	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
690850006156	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
690850006157	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
690850006158	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
690850006159	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
690850006160	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
690850006161	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
690850006162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850006163	active site
690850006164	phosphorylation site [posttranslational modification]
690850006165	intermolecular recognition site; other site
690850006166	dimerization interface [polypeptide binding]; other site
690850006167	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850006168	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850006169	metal binding site [ion binding]; metal-binding site
690850006170	active site
690850006171	I-site; other site
690850006172	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
690850006173	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850006174	TPR motif; other site
690850006175	binding surface
690850006176	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850006177	TPR motif; other site
690850006178	binding surface
690850006179	TPR repeat; Region: TPR_11; pfam13414
690850006180	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
690850006181	putative FMN binding site [chemical binding]; other site
690850006182	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
690850006183	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
690850006184	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
690850006185	comF family protein; Region: comF; TIGR00201
690850006186	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
690850006187	active site
690850006188	Isochorismatase family; Region: Isochorismatase; pfam00857
690850006189	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
690850006190	catalytic triad [active]
690850006191	conserved cis-peptide bond; other site
690850006192	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
690850006193	nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662
690850006194	active site
690850006195	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
690850006196	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
690850006197	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
690850006198	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
690850006199	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
690850006200	GTPase CgtA; Reviewed; Region: obgE; PRK12299
690850006201	GTP1/OBG; Region: GTP1_OBG; pfam01018
690850006202	Obg GTPase; Region: Obg; cd01898
690850006203	G1 box; other site
690850006204	GTP/Mg2+ binding site [chemical binding]; other site
690850006205	Switch I region; other site
690850006206	G2 box; other site
690850006207	G3 box; other site
690850006208	Switch II region; other site
690850006209	G4 box; other site
690850006210	G5 box; other site
690850006211	gamma-glutamyl kinase; Provisional; Region: PRK05429
690850006212	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
690850006213	nucleotide binding site [chemical binding]; other site
690850006214	homotetrameric interface [polypeptide binding]; other site
690850006215	putative phosphate binding site [ion binding]; other site
690850006216	putative allosteric binding site; other site
690850006217	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
690850006218	Cache domain; Region: Cache_1; pfam02743
690850006219	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850006220	dimerization interface [polypeptide binding]; other site
690850006221	PAS domain; Region: PAS_9; pfam13426
690850006222	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850006223	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850006224	dimer interface [polypeptide binding]; other site
690850006225	putative CheW interface [polypeptide binding]; other site
690850006226	Soluble P-type ATPase [General function prediction only]; Region: COG4087
690850006227	phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972
690850006228	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
690850006229	Walker A/P-loop; other site
690850006230	ATP binding site [chemical binding]; other site
690850006231	Q-loop/lid; other site
690850006232	ABC transporter signature motif; other site
690850006233	Walker B; other site
690850006234	D-loop; other site
690850006235	H-loop/switch region; other site
690850006236	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
690850006237	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
690850006238	dimer interface [polypeptide binding]; other site
690850006239	conserved gate region; other site
690850006240	putative PBP binding loops; other site
690850006241	ABC-ATPase subunit interface; other site
690850006242	PBP superfamily domain; Region: PBP_like_2; cl17296
690850006243	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
690850006244	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
690850006245	DEAD-like helicases superfamily; Region: DEXDc; smart00487
690850006246	ATP binding site [chemical binding]; other site
690850006247	Mg++ binding site [ion binding]; other site
690850006248	motif III; other site
690850006249	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
690850006250	nucleotide binding region [chemical binding]; other site
690850006251	ATP-binding site [chemical binding]; other site
690850006252	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
690850006253	RNA binding site [nucleotide binding]; other site
690850006254	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
690850006255	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
690850006256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
690850006257	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850006258	dimer interface [polypeptide binding]; other site
690850006259	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
690850006260	putative CheW interface [polypeptide binding]; other site
690850006261	Heme NO binding; Region: HNOB; pfam07700
690850006262	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
690850006263	MarR family; Region: MarR_2; cl17246
690850006264	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
690850006265	Protein export membrane protein; Region: SecD_SecF; cl14618
690850006266	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
690850006267	HlyD family secretion protein; Region: HlyD_3; pfam13437
690850006268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
690850006269	active site
690850006270	phosphorylation site [posttranslational modification]
690850006271	intermolecular recognition site; other site
690850006272	dimerization interface [polypeptide binding]; other site
690850006273	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
690850006274	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850006275	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850006276	active site
690850006277	phosphorylation site [posttranslational modification]
690850006278	intermolecular recognition site; other site
690850006279	dimerization interface [polypeptide binding]; other site
690850006280	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850006281	Walker A motif; other site
690850006282	ATP binding site [chemical binding]; other site
690850006283	Walker B motif; other site
690850006284	arginine finger; other site
690850006285	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850006286	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
690850006287	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
690850006288	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850006289	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850006290	putative active site [active]
690850006291	heme pocket [chemical binding]; other site
690850006292	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
690850006293	dimer interface [polypeptide binding]; other site
690850006294	phosphorylation site [posttranslational modification]
690850006295	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850006296	ATP binding site [chemical binding]; other site
690850006297	Mg2+ binding site [ion binding]; other site
690850006298	G-X-G motif; other site
690850006299	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
690850006300	linker region; other site
690850006301	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850006302	dimerization interface [polypeptide binding]; other site
690850006303	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850006304	dimer interface [polypeptide binding]; other site
690850006305	phosphorylation site [posttranslational modification]
690850006306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850006307	ATP binding site [chemical binding]; other site
690850006308	Mg2+ binding site [ion binding]; other site
690850006309	G-X-G motif; other site
690850006310	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
690850006311	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850006312	active site
690850006313	phosphorylation site [posttranslational modification]
690850006314	intermolecular recognition site; other site
690850006315	dimerization interface [polypeptide binding]; other site
690850006316	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
690850006317	DNA binding site [nucleotide binding]
690850006318	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
690850006319	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
690850006320	HlyD family secretion protein; Region: HlyD_3; pfam13437
690850006321	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
690850006322	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
690850006323	Walker A/P-loop; other site
690850006324	ATP binding site [chemical binding]; other site
690850006325	Q-loop/lid; other site
690850006326	ABC transporter signature motif; other site
690850006327	Walker B; other site
690850006328	D-loop; other site
690850006329	H-loop/switch region; other site
690850006330	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
690850006331	FtsX-like permease family; Region: FtsX; pfam02687
690850006332	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
690850006333	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
690850006334	IHF - DNA interface [nucleotide binding]; other site
690850006335	IHF dimer interface [polypeptide binding]; other site
690850006336	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850006337	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
690850006338	putative ADP-binding pocket [chemical binding]; other site
690850006339	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
690850006340	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
690850006341	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
690850006342	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
690850006343	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
690850006344	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
690850006345	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
690850006346	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
690850006347	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
690850006348	ATP binding site [chemical binding]; other site
690850006349	Mg2+ binding site [ion binding]; other site
690850006350	G-X-G motif; other site
690850006351	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
690850006352	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
690850006353	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
690850006354	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
690850006355	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850006356	dimer interface [polypeptide binding]; other site
690850006357	phosphorylation site [posttranslational modification]
690850006358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850006359	ATP binding site [chemical binding]; other site
690850006360	Mg2+ binding site [ion binding]; other site
690850006361	G-X-G motif; other site
690850006362	Response regulator receiver domain; Region: Response_reg; pfam00072
690850006363	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850006364	active site
690850006365	phosphorylation site [posttranslational modification]
690850006366	intermolecular recognition site; other site
690850006367	dimerization interface [polypeptide binding]; other site
690850006368	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850006369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850006370	active site
690850006371	phosphorylation site [posttranslational modification]
690850006372	intermolecular recognition site; other site
690850006373	dimerization interface [polypeptide binding]; other site
690850006374	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
690850006375	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850006376	putative active site [active]
690850006377	heme pocket [chemical binding]; other site
690850006378	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850006379	dimer interface [polypeptide binding]; other site
690850006380	phosphorylation site [posttranslational modification]
690850006381	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850006382	ATP binding site [chemical binding]; other site
690850006383	Mg2+ binding site [ion binding]; other site
690850006384	G-X-G motif; other site
690850006385	Response regulator receiver domain; Region: Response_reg; pfam00072
690850006386	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850006387	active site
690850006388	phosphorylation site [posttranslational modification]
690850006389	intermolecular recognition site; other site
690850006390	dimerization interface [polypeptide binding]; other site
690850006391	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850006392	Coenzyme A binding pocket [chemical binding]; other site
690850006393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
690850006394	Major Facilitator Superfamily; Region: MFS_1; pfam07690
690850006395	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
690850006396	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
690850006397	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
690850006398	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
690850006399	xanthine dehydrogenase D subunit; Region: pucD; TIGR03196
690850006400	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
690850006401	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
690850006402	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
690850006403	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
690850006404	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850006405	homodimer interface [polypeptide binding]; other site
690850006406	catalytic residue [active]
690850006407	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
690850006408	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
690850006409	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
690850006410	anti sigma factor interaction site; other site
690850006411	regulatory phosphorylation site [posttranslational modification]; other site
690850006412	Cache domain; Region: Cache_1; pfam02743
690850006413	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
690850006414	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850006415	dimerization interface [polypeptide binding]; other site
690850006416	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
690850006417	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
690850006418	NMT1/THI5 like; Region: NMT1; pfam09084
690850006419	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
690850006420	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
690850006421	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
690850006422	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
690850006423	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
690850006424	Cysteine-rich domain; Region: CCG; pfam02754
690850006425	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
690850006426	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
690850006427	homodimer interface [polypeptide binding]; other site
690850006428	metal binding site [ion binding]; metal-binding site
690850006429	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
690850006430	homodimer interface [polypeptide binding]; other site
690850006431	active site
690850006432	putative chemical substrate binding site [chemical binding]; other site
690850006433	metal binding site [ion binding]; metal-binding site
690850006434	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
690850006435	Colicin V production protein; Region: Colicin_V; pfam02674
690850006436	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
690850006437	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
690850006438	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
690850006439	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
690850006440	Na binding site [ion binding]; other site
690850006441	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
690850006442	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
690850006443	ligand binding site [chemical binding]; other site
690850006444	flexible hinge region; other site
690850006445	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
690850006446	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
690850006447	metal binding triad; other site
690850006448	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
690850006449	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
690850006450	active site
690850006451	catalytic site [active]
690850006452	substrate binding site [chemical binding]; other site
690850006453	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
690850006454	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
690850006455	Uncharacterized ArCR, COG2043; Region: DUF169; cl00894
690850006456	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
690850006457	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
690850006458	MarR family; Region: MarR_2; pfam12802
690850006459	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850006460	dimer interface [polypeptide binding]; other site
690850006461	phosphorylation site [posttranslational modification]
690850006462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850006463	ATP binding site [chemical binding]; other site
690850006464	Mg2+ binding site [ion binding]; other site
690850006465	G-X-G motif; other site
690850006466	Response regulator receiver domain; Region: Response_reg; pfam00072
690850006467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850006468	active site
690850006469	phosphorylation site [posttranslational modification]
690850006470	intermolecular recognition site; other site
690850006471	dimerization interface [polypeptide binding]; other site
690850006472	Response regulator receiver domain; Region: Response_reg; pfam00072
690850006473	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850006474	active site
690850006475	phosphorylation site [posttranslational modification]
690850006476	intermolecular recognition site; other site
690850006477	dimerization interface [polypeptide binding]; other site
690850006478	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850006479	binding surface
690850006480	TPR motif; other site
690850006481	TPR repeat; Region: TPR_11; pfam13414
690850006482	intracellular protease, PfpI family; Region: PfpI; TIGR01382
690850006483	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
690850006484	conserved cys residue [active]
690850006485	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
690850006486	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
690850006487	motif 1; other site
690850006488	active site
690850006489	motif 2; other site
690850006490	motif 3; other site
690850006491	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
690850006492	DHHA1 domain; Region: DHHA1; pfam02272
690850006493	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
690850006494	recombinase A; Provisional; Region: recA; PRK09354
690850006495	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
690850006496	hexamer interface [polypeptide binding]; other site
690850006497	Walker A motif; other site
690850006498	ATP binding site [chemical binding]; other site
690850006499	Walker B motif; other site
690850006500	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
690850006501	Ligand Binding Site [chemical binding]; other site
690850006502	Domain of unknown function (DUF814); Region: DUF814; pfam05670
690850006503	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
690850006504	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
690850006505	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
690850006506	ribonuclease R; Region: RNase_R; TIGR02063
690850006507	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
690850006508	RNB domain; Region: RNB; pfam00773
690850006509	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
690850006510	RNA binding site [nucleotide binding]; other site
690850006511	Ion channel; Region: Ion_trans_2; pfam07885
690850006512	Uncharacterized conserved protein [Function unknown]; Region: COG0398
690850006513	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
690850006514	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
690850006515	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
690850006516	Ligand binding site; other site
690850006517	Putative Catalytic site; other site
690850006518	DXD motif; other site
690850006519	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
690850006520	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850006521	Coenzyme A binding pocket [chemical binding]; other site
690850006522	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
690850006523	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
690850006524	active site
690850006525	Zn binding site [ion binding]; other site
690850006526	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
690850006527	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850006528	Coenzyme A binding pocket [chemical binding]; other site
690850006529	D-alanyl-alanine synthetase A; Provisional; Region: PRK14569
690850006530	ATP-grasp domain; Region: ATP-grasp_4; cl17255
690850006531	D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205
690850006532	ATP-grasp domain; Region: ATP-grasp_4; cl17255
690850006533	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
690850006534	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850006535	FeS/SAM binding site; other site
690850006536	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
690850006537	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850006538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
690850006539	active site
690850006540	phosphorylation site [posttranslational modification]
690850006541	dimerization interface [polypeptide binding]; other site
690850006542	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850006543	Walker A motif; other site
690850006544	ATP binding site [chemical binding]; other site
690850006545	Walker B motif; other site
690850006546	arginine finger; other site
690850006547	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
690850006548	Fe-S cluster binding site [ion binding]; other site
690850006549	active site
690850006550	FOG: CBS domain [General function prediction only]; Region: COG0517
690850006551	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
690850006552	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
690850006553	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
690850006554	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
690850006555	putative active site [active]
690850006556	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
690850006557	Tetratricopeptide repeat; Region: TPR_16; pfam13432
690850006558	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850006559	binding surface
690850006560	TPR motif; other site
690850006561	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
690850006562	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850006563	binding surface
690850006564	TPR motif; other site
690850006565	TPR repeat; Region: TPR_11; pfam13414
690850006566	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850006567	binding surface
690850006568	TPR motif; other site
690850006569	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503
690850006570	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
690850006571	alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392
690850006572	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
690850006573	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
690850006574	DNA binding residues [nucleotide binding]
690850006575	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
690850006576	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
690850006577	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
690850006578	substrate binding pocket [chemical binding]; other site
690850006579	dimer interface [polypeptide binding]; other site
690850006580	inhibitor binding site; inhibition site
690850006581	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
690850006582	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
690850006583	B12 binding site [chemical binding]; other site
690850006584	cobalt ligand [ion binding]; other site
690850006585	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
690850006586	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
690850006587	catalytic residues [active]
690850006588	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850006589	Coenzyme A binding pocket [chemical binding]; other site
690850006590	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
690850006591	active site
690850006592	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
690850006593	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
690850006594	DNA repair protein RadA; Provisional; Region: PRK11823
690850006595	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
690850006596	Walker A motif; other site
690850006597	ATP binding site [chemical binding]; other site
690850006598	Walker B motif; other site
690850006599	EamA-like transporter family; Region: EamA; pfam00892
690850006600	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
690850006601	EamA-like transporter family; Region: EamA; pfam00892
690850006602	flagellin; Provisional; Region: PRK12802
690850006603	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
690850006604	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
690850006605	putative peptidase; Provisional; Region: PRK11649
690850006606	Peptidase family M23; Region: Peptidase_M23; pfam01551
690850006607	Plasmid replication protein; Region: Rep_2; pfam01719
690850006608	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
690850006609	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
690850006610	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
690850006611	lipoyl synthase; Provisional; Region: PRK05481
690850006612	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850006613	FeS/SAM binding site; other site
690850006614	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
690850006615	Bacterial SH3 domain; Region: SH3_3; pfam08239
690850006616	Modifier of rudimentary (Mod(r)) protein; Region: Mod_r; pfam07200
690850006617	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
690850006618	DHH family; Region: DHH; pfam01368
690850006619	DHHA1 domain; Region: DHHA1; pfam02272
690850006620	Tetratricopeptide repeat; Region: TPR_12; pfam13424
690850006621	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850006622	binding surface
690850006623	TPR motif; other site
690850006624	TPR repeat; Region: TPR_11; pfam13414
690850006625	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
690850006626	active site
690850006627	dimer interface [polypeptide binding]; other site
690850006628	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
690850006629	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
690850006630	catalytic site [active]
690850006631	G-X2-G-X-G-K; other site
690850006632	hypothetical protein; Provisional; Region: PRK04323
690850006633	hypothetical protein; Provisional; Region: PRK11820
690850006634	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
690850006635	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
690850006636	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
690850006637	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
690850006638	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850006639	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
690850006640	binding surface
690850006641	TPR repeat; Region: TPR_11; pfam13414
690850006642	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
690850006643	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
690850006644	Ligand Binding Site [chemical binding]; other site
690850006645	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
690850006646	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
690850006647	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
690850006648	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
690850006649	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
690850006650	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
690850006651	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
690850006652	nucleotide binding site [chemical binding]; other site
690850006653	NEF interaction site [polypeptide binding]; other site
690850006654	SBD interface [polypeptide binding]; other site
690850006655	GrpE; Region: GrpE; pfam01025
690850006656	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
690850006657	dimer interface [polypeptide binding]; other site
690850006658	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
690850006659	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
690850006660	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
690850006661	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
690850006662	NADP binding site [chemical binding]; other site
690850006663	active site
690850006664	putative substrate binding site [chemical binding]; other site
690850006665	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
690850006666	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
690850006667	NAD binding site [chemical binding]; other site
690850006668	substrate binding site [chemical binding]; other site
690850006669	homodimer interface [polypeptide binding]; other site
690850006670	active site
690850006671	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
690850006672	Protein of unknown function, DUF482; Region: DUF482; pfam04339
690850006673	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
690850006674	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
690850006675	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
690850006676	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
690850006677	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
690850006678	FAD binding pocket [chemical binding]; other site
690850006679	FAD binding motif [chemical binding]; other site
690850006680	phosphate binding motif [ion binding]; other site
690850006681	beta-alpha-beta structure motif; other site
690850006682	NAD binding pocket [chemical binding]; other site
690850006683	Iron coordination center [ion binding]; other site
690850006684	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
690850006685	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
690850006686	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
690850006687	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
690850006688	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850006689	ABC transporter signature motif; other site
690850006690	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
690850006691	pyrroline-5-carboxylate reductase; Region: PLN02688
690850006692	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
690850006693	active site
690850006694	multimer interface [polypeptide binding]; other site
690850006695	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
690850006696	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850006697	Walker A/P-loop; other site
690850006698	ATP binding site [chemical binding]; other site
690850006699	Q-loop/lid; other site
690850006700	ABC transporter signature motif; other site
690850006701	Walker B; other site
690850006702	D-loop; other site
690850006703	H-loop/switch region; other site
690850006704	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
690850006705	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
690850006706	TM-ABC transporter signature motif; other site
690850006707	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
690850006708	zinc binding site [ion binding]; other site
690850006709	putative ligand binding site [chemical binding]; other site
690850006710	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
690850006711	NodB motif; other site
690850006712	putative active site [active]
690850006713	putative catalytic site [active]
690850006714	Zn binding site [ion binding]; other site
690850006715	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
690850006716	C-terminal peptidase (prc); Region: prc; TIGR00225
690850006717	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
690850006718	protein binding site [polypeptide binding]; other site
690850006719	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
690850006720	Catalytic dyad [active]
690850006721	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
690850006722	Peptidase family M23; Region: Peptidase_M23; pfam01551
690850006723	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
690850006724	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
690850006725	minor groove reading motif; other site
690850006726	helix-hairpin-helix signature motif; other site
690850006727	substrate binding pocket [chemical binding]; other site
690850006728	active site
690850006729	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
690850006730	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850006731	S-adenosylmethionine binding site [chemical binding]; other site
690850006732	GTPase RsgA; Reviewed; Region: PRK01889
690850006733	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
690850006734	RNA binding site [nucleotide binding]; other site
690850006735	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
690850006736	GTPase/Zn-binding domain interface [polypeptide binding]; other site
690850006737	GTP/Mg2+ binding site [chemical binding]; other site
690850006738	G4 box; other site
690850006739	G5 box; other site
690850006740	G1 box; other site
690850006741	Switch I region; other site
690850006742	G2 box; other site
690850006743	G3 box; other site
690850006744	Switch II region; other site
690850006745	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
690850006746	dimerization interface [polypeptide binding]; other site
690850006747	putative DNA binding site [nucleotide binding]; other site
690850006748	putative Zn2+ binding site [ion binding]; other site
690850006749	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
690850006750	DGC domain; Region: DGC; pfam08859
690850006751	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
690850006752	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
690850006753	catalytic residues [active]
690850006754	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
690850006755	Predicted permease; Region: DUF318; cl17795
690850006756	Predicted permease; Region: DUF318; cl17795
690850006757	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
690850006758	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
690850006759	catalytic residues [active]
690850006760	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
690850006761	dimerization interface [polypeptide binding]; other site
690850006762	putative DNA binding site [nucleotide binding]; other site
690850006763	putative Zn2+ binding site [ion binding]; other site
690850006764	Methyltransferase domain; Region: Methyltransf_31; pfam13847
690850006765	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850006766	S-adenosylmethionine binding site [chemical binding]; other site
690850006767	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
690850006768	dimerization interface [polypeptide binding]; other site
690850006769	putative DNA binding site [nucleotide binding]; other site
690850006770	putative Zn2+ binding site [ion binding]; other site
690850006771	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
690850006772	arsenical-resistance protein; Region: acr3; TIGR00832
690850006773	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
690850006774	Low molecular weight phosphatase family; Region: LMWPc; cd00115
690850006775	active site
690850006776	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850006777	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850006778	dimerization interface [polypeptide binding]; other site
690850006779	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850006780	dimer interface [polypeptide binding]; other site
690850006781	phosphorylation site [posttranslational modification]
690850006782	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850006783	ATP binding site [chemical binding]; other site
690850006784	Mg2+ binding site [ion binding]; other site
690850006785	G-X-G motif; other site
690850006786	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850006787	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850006788	active site
690850006789	phosphorylation site [posttranslational modification]
690850006790	intermolecular recognition site; other site
690850006791	dimerization interface [polypeptide binding]; other site
690850006792	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850006793	Walker A motif; other site
690850006794	ATP binding site [chemical binding]; other site
690850006795	Walker B motif; other site
690850006796	arginine finger; other site
690850006797	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850006798	Response regulator receiver domain; Region: Response_reg; pfam00072
690850006799	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850006800	active site
690850006801	phosphorylation site [posttranslational modification]
690850006802	intermolecular recognition site; other site
690850006803	dimerization interface [polypeptide binding]; other site
690850006804	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850006805	Walker A motif; other site
690850006806	ATP binding site [chemical binding]; other site
690850006807	Walker B motif; other site
690850006808	arginine finger; other site
690850006809	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
690850006810	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
690850006811	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
690850006812	Ligand Binding Site [chemical binding]; other site
690850006813	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
690850006814	Ligand Binding Site [chemical binding]; other site
690850006815	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
690850006816	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
690850006817	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
690850006818	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
690850006819	RNA binding site [nucleotide binding]; other site
690850006820	Predicted membrane protein [Function unknown]; Region: COG3431
690850006821	Uncharacterized conserved protein [Function unknown]; Region: COG2006
690850006822	Domain of unknown function (DUF362); Region: DUF362; pfam04015
690850006823	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
690850006824	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
690850006825	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
690850006826	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
690850006827	Cysteine-rich domain; Region: CCG; pfam02754
690850006828	Cysteine-rich domain; Region: CCG; pfam02754
690850006829	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
690850006830	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
690850006831	propionate/acetate kinase; Provisional; Region: PRK12379
690850006832	phosphate acetyltransferase; Reviewed; Region: PRK05632
690850006833	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
690850006834	DRTGG domain; Region: DRTGG; pfam07085
690850006835	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
690850006836	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850006837	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
690850006838	Cysteine-rich domain; Region: CCG; pfam02754
690850006839	Cysteine-rich domain; Region: CCG; pfam02754
690850006840	FAD binding domain; Region: FAD_binding_4; pfam01565
690850006841	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
690850006842	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
690850006843	L-lactate permease; Region: Lactate_perm; cl00701
690850006844	L-lactate permease; Region: Lactate_perm; cl00701
690850006845	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
690850006846	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
690850006847	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
690850006848	dimer interface [polypeptide binding]; other site
690850006849	PYR/PP interface [polypeptide binding]; other site
690850006850	TPP binding site [chemical binding]; other site
690850006851	substrate binding site [chemical binding]; other site
690850006852	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
690850006853	Domain of unknown function; Region: EKR; pfam10371
690850006854	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850006855	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
690850006856	TPP-binding site [chemical binding]; other site
690850006857	dimer interface [polypeptide binding]; other site
690850006858	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850006859	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850006860	active site
690850006861	phosphorylation site [posttranslational modification]
690850006862	intermolecular recognition site; other site
690850006863	dimerization interface [polypeptide binding]; other site
690850006864	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850006865	Walker A motif; other site
690850006866	ATP binding site [chemical binding]; other site
690850006867	Walker B motif; other site
690850006868	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
690850006869	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850006870	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850006871	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850006872	putative active site [active]
690850006873	heme pocket [chemical binding]; other site
690850006874	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
690850006875	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850006876	putative active site [active]
690850006877	heme pocket [chemical binding]; other site
690850006878	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850006879	dimer interface [polypeptide binding]; other site
690850006880	phosphorylation site [posttranslational modification]
690850006881	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850006882	ATP binding site [chemical binding]; other site
690850006883	Mg2+ binding site [ion binding]; other site
690850006884	G-X-G motif; other site
690850006885	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850006886	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850006887	active site
690850006888	phosphorylation site [posttranslational modification]
690850006889	intermolecular recognition site; other site
690850006890	dimerization interface [polypeptide binding]; other site
690850006891	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
690850006892	S17 interaction site [polypeptide binding]; other site
690850006893	S8 interaction site; other site
690850006894	16S rRNA interaction site [nucleotide binding]; other site
690850006895	streptomycin interaction site [chemical binding]; other site
690850006896	23S rRNA interaction site [nucleotide binding]; other site
690850006897	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
690850006898	30S ribosomal protein S7; Validated; Region: PRK05302
690850006899	elongation factor G; Reviewed; Region: PRK00007
690850006900	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
690850006901	G1 box; other site
690850006902	putative GEF interaction site [polypeptide binding]; other site
690850006903	GTP/Mg2+ binding site [chemical binding]; other site
690850006904	Switch I region; other site
690850006905	G2 box; other site
690850006906	G3 box; other site
690850006907	Switch II region; other site
690850006908	G4 box; other site
690850006909	G5 box; other site
690850006910	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
690850006911	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
690850006912	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
690850006913	elongation factor Tu; Reviewed; Region: PRK00049
690850006914	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
690850006915	G1 box; other site
690850006916	GEF interaction site [polypeptide binding]; other site
690850006917	GTP/Mg2+ binding site [chemical binding]; other site
690850006918	Switch I region; other site
690850006919	G2 box; other site
690850006920	G3 box; other site
690850006921	Switch II region; other site
690850006922	G4 box; other site
690850006923	G5 box; other site
690850006924	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
690850006925	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
690850006926	Antibiotic Binding Site [chemical binding]; other site
690850006927	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
690850006928	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
690850006929	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
690850006930	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
690850006931	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
690850006932	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
690850006933	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
690850006934	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
690850006935	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
690850006936	putative translocon binding site; other site
690850006937	protein-rRNA interface [nucleotide binding]; other site
690850006938	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
690850006939	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
690850006940	G-X-X-G motif; other site
690850006941	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
690850006942	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
690850006943	23S rRNA interface [nucleotide binding]; other site
690850006944	5S rRNA interface [nucleotide binding]; other site
690850006945	putative antibiotic binding site [chemical binding]; other site
690850006946	L25 interface [polypeptide binding]; other site
690850006947	L27 interface [polypeptide binding]; other site
690850006948	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
690850006949	23S rRNA interface [nucleotide binding]; other site
690850006950	putative translocon interaction site; other site
690850006951	signal recognition particle (SRP54) interaction site; other site
690850006952	L23 interface [polypeptide binding]; other site
690850006953	trigger factor interaction site; other site
690850006954	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
690850006955	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
690850006956	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
690850006957	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
690850006958	RNA binding site [nucleotide binding]; other site
690850006959	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
690850006960	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
690850006961	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
690850006962	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
690850006963	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
690850006964	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
690850006965	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
690850006966	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
690850006967	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
690850006968	5S rRNA interface [nucleotide binding]; other site
690850006969	L27 interface [polypeptide binding]; other site
690850006970	23S rRNA interface [nucleotide binding]; other site
690850006971	L5 interface [polypeptide binding]; other site
690850006972	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
690850006973	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
690850006974	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
690850006975	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
690850006976	23S rRNA binding site [nucleotide binding]; other site
690850006977	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
690850006978	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
690850006979	SecY translocase; Region: SecY; pfam00344
690850006980	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
690850006981	active site
690850006982	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
690850006983	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
690850006984	30S ribosomal protein S13; Region: bact_S13; TIGR03631
690850006985	30S ribosomal protein S11; Validated; Region: PRK05309
690850006986	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
690850006987	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
690850006988	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
690850006989	RNA binding surface [nucleotide binding]; other site
690850006990	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
690850006991	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
690850006992	alphaNTD - beta interaction site [polypeptide binding]; other site
690850006993	alphaNTD homodimer interface [polypeptide binding]; other site
690850006994	alphaNTD - beta' interaction site [polypeptide binding]; other site
690850006995	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
690850006996	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
690850006997	Transcriptional regulator [Transcription]; Region: LysR; COG0583
690850006998	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
690850006999	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
690850007000	putative dimerization interface [polypeptide binding]; other site
690850007001	selenophosphate synthetase; Provisional; Region: PRK00943
690850007002	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
690850007003	dimerization interface [polypeptide binding]; other site
690850007004	putative ATP binding site [chemical binding]; other site
690850007005	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
690850007006	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
690850007007	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850007008	homodimer interface [polypeptide binding]; other site
690850007009	catalytic residue [active]
690850007010	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
690850007011	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
690850007012	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850007013	dimerization interface [polypeptide binding]; other site
690850007014	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850007015	dimer interface [polypeptide binding]; other site
690850007016	putative CheW interface [polypeptide binding]; other site
690850007017	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
690850007018	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
690850007019	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
690850007020	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
690850007021	putative active site [active]
690850007022	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
690850007023	Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359
690850007024	RNase_H superfamily; Region: RNase_H_2; pfam13482
690850007025	active site
690850007026	catalytic site [active]
690850007027	substrate binding site [chemical binding]; other site
690850007028	active site
690850007029	substrate binding site [chemical binding]; other site
690850007030	catalytic site [active]
690850007031	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
690850007032	putative catalytic site [active]
690850007033	putative metal binding site [ion binding]; other site
690850007034	putative phosphate binding site [ion binding]; other site
690850007035	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
690850007036	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
690850007037	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
690850007038	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
690850007039	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
690850007040	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
690850007041	Protein of unknown function (DUF770); Region: DUF770; pfam05591
690850007042	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
690850007043	Protein of unknown function (DUF877); Region: DUF877; pfam05943
690850007044	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
690850007045	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
690850007046	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
690850007047	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
690850007048	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
690850007049	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
690850007050	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850007051	Walker A motif; other site
690850007052	ATP binding site [chemical binding]; other site
690850007053	Walker B motif; other site
690850007054	arginine finger; other site
690850007055	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850007056	Walker A motif; other site
690850007057	ATP binding site [chemical binding]; other site
690850007058	Walker B motif; other site
690850007059	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
690850007060	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
690850007061	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
690850007062	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
690850007063	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937
690850007064	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
690850007065	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
690850007066	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
690850007067	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
690850007068	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
690850007069	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
690850007070	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
690850007071	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
690850007072	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
690850007073	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
690850007074	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
690850007075	Protein of unknown function (DUF3540); Region: DUF3540; pfam12059
690850007076	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
690850007077	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
690850007078	Smr domain; Region: Smr; pfam01713
690850007079	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
690850007080	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
690850007081	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
690850007082	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
690850007083	HSP70 interaction site [polypeptide binding]; other site
690850007084	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
690850007085	substrate binding site [polypeptide binding]; other site
690850007086	dimer interface [polypeptide binding]; other site
690850007087	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
690850007088	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
690850007089	Clp amino terminal domain; Region: Clp_N; pfam02861
690850007090	Clp amino terminal domain; Region: Clp_N; pfam02861
690850007091	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850007092	Walker A motif; other site
690850007093	ATP binding site [chemical binding]; other site
690850007094	Walker B motif; other site
690850007095	arginine finger; other site
690850007096	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850007097	Walker A motif; other site
690850007098	ATP binding site [chemical binding]; other site
690850007099	Walker B motif; other site
690850007100	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
690850007101	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
690850007102	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
690850007103	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
690850007104	Protein of unknown function DUF115; Region: MAF_flag10; pfam01973
690850007105	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
690850007106	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
690850007107	dimer interface [polypeptide binding]; other site
690850007108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850007109	catalytic residue [active]
690850007110	Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215
690850007111	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
690850007112	DNA-binding site [nucleotide binding]; DNA binding site
690850007113	RNA-binding motif; other site
690850007114	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
690850007115	rRNA binding site [nucleotide binding]; other site
690850007116	predicted 30S ribosome binding site; other site
690850007117	purine nucleoside phosphorylase; Provisional; Region: PRK08202
690850007118	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
690850007119	flagellar motor protein MotP; Reviewed; Region: PRK06926
690850007120	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
690850007121	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
690850007122	ligand binding site [chemical binding]; other site
690850007123	PilZ domain; Region: PilZ; pfam07238
690850007124	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
690850007125	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
690850007126	ATP-grasp domain; Region: ATP-grasp_4; cl17255
690850007127	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
690850007128	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
690850007129	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
690850007130	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
690850007131	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
690850007132	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
690850007133	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
690850007134	FAD binding domain; Region: FAD_binding_4; pfam01565
690850007135	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
690850007136	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
690850007137	Cysteine-rich domain; Region: CCG; pfam02754
690850007138	Cysteine-rich domain; Region: CCG; pfam02754
690850007139	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
690850007140	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
690850007141	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
690850007142	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850007143	putative active site [active]
690850007144	heme pocket [chemical binding]; other site
690850007145	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850007146	dimer interface [polypeptide binding]; other site
690850007147	phosphorylation site [posttranslational modification]
690850007148	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850007149	ATP binding site [chemical binding]; other site
690850007150	Mg2+ binding site [ion binding]; other site
690850007151	G-X-G motif; other site
690850007152	CHASE4 domain; Region: CHASE4; pfam05228
690850007153	PAS fold; Region: PAS_4; pfam08448
690850007154	PAS domain S-box; Region: sensory_box; TIGR00229
690850007155	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850007156	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850007157	metal binding site [ion binding]; metal-binding site
690850007158	active site
690850007159	I-site; other site
690850007160	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
690850007161	Response regulator receiver domain; Region: Response_reg; pfam00072
690850007162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850007163	active site
690850007164	phosphorylation site [posttranslational modification]
690850007165	intermolecular recognition site; other site
690850007166	dimerization interface [polypeptide binding]; other site
690850007167	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
690850007168	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
690850007169	LabA_like proteins; Region: LabA_like; cd06167
690850007170	putative metal binding site [ion binding]; other site
690850007171	Uncharacterized conserved protein [Function unknown]; Region: COG1432
690850007172	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
690850007173	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
690850007174	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
690850007175	FAD binding pocket [chemical binding]; other site
690850007176	FAD binding motif [chemical binding]; other site
690850007177	phosphate binding motif [ion binding]; other site
690850007178	beta-alpha-beta structure motif; other site
690850007179	NAD binding pocket [chemical binding]; other site
690850007180	Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453
690850007181	active site
690850007182	catalytic residues [active]
690850007183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850007184	active site
690850007185	dimerization interface [polypeptide binding]; other site
690850007186	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850007187	binding surface
690850007188	Tetratricopeptide repeat; Region: TPR_16; pfam13432
690850007189	TPR motif; other site
690850007190	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
690850007191	binding surface
690850007192	TPR motif; other site
690850007193	Tetratricopeptide repeat; Region: TPR_12; pfam13424
690850007194	TPR repeat; Region: TPR_11; pfam13414
690850007195	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850007196	binding surface
690850007197	TPR motif; other site
690850007198	TPR repeat; Region: TPR_11; pfam13414
690850007199	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850007200	binding surface
690850007201	TPR motif; other site
690850007202	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
690850007203	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
690850007204	MarR family; Region: MarR_2; pfam12802
690850007205	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
690850007206	Catalytic domain of Protein Kinases; Region: PKc; cd00180
690850007207	active site
690850007208	ATP binding site [chemical binding]; other site
690850007209	substrate binding site [chemical binding]; other site
690850007210	activation loop (A-loop); other site
690850007211	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
690850007212	biotin synthase; Region: bioB; TIGR00433
690850007213	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850007214	FeS/SAM binding site; other site
690850007215	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
690850007216	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
690850007217	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
690850007218	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
690850007219	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
690850007220	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
690850007221	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
690850007222	TM-ABC transporter signature motif; other site
690850007223	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
690850007224	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
690850007225	TM-ABC transporter signature motif; other site
690850007226	Family description; Region: VCBS; pfam13517
690850007227	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
690850007228	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
690850007229	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850007230	binding surface
690850007231	TPR motif; other site
690850007232	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
690850007233	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
690850007234	catalytic triad [active]
690850007235	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
690850007236	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
690850007237	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
690850007238	NAD binding site [chemical binding]; other site
690850007239	homodimer interface [polypeptide binding]; other site
690850007240	active site
690850007241	substrate binding site [chemical binding]; other site
690850007242	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
690850007243	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
690850007244	NAD binding site [chemical binding]; other site
690850007245	putative substrate binding site 2 [chemical binding]; other site
690850007246	putative substrate binding site 1 [chemical binding]; other site
690850007247	active site
690850007248	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850007249	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850007250	metal binding site [ion binding]; metal-binding site
690850007251	active site
690850007252	I-site; other site
690850007253	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
690850007254	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
690850007255	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
690850007256	active site
690850007257	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
690850007258	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
690850007259	putative CheA interaction surface; other site
690850007260	CHASE3 domain; Region: CHASE3; pfam05227
690850007261	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850007262	dimerization interface [polypeptide binding]; other site
690850007263	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850007264	dimer interface [polypeptide binding]; other site
690850007265	putative CheW interface [polypeptide binding]; other site
690850007266	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
690850007267	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
690850007268	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
690850007269	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
690850007270	EamA-like transporter family; Region: EamA; pfam00892
690850007271	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
690850007272	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850007273	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850007274	active site
690850007275	phosphorylation site [posttranslational modification]
690850007276	intermolecular recognition site; other site
690850007277	dimerization interface [polypeptide binding]; other site
690850007278	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
690850007279	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
690850007280	Walker A/P-loop; other site
690850007281	ATP binding site [chemical binding]; other site
690850007282	Q-loop/lid; other site
690850007283	ABC transporter signature motif; other site
690850007284	Walker B; other site
690850007285	D-loop; other site
690850007286	H-loop/switch region; other site
690850007287	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
690850007288	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
690850007289	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
690850007290	Walker A/P-loop; other site
690850007291	ATP binding site [chemical binding]; other site
690850007292	Q-loop/lid; other site
690850007293	ABC transporter signature motif; other site
690850007294	Walker B; other site
690850007295	D-loop; other site
690850007296	H-loop/switch region; other site
690850007297	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
690850007298	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
690850007299	Glucose inhibited division protein A; Region: GIDA; pfam01134
690850007300	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
690850007301	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
690850007302	active site
690850007303	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
690850007304	active site 2 [active]
690850007305	active site 1 [active]
690850007306	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
690850007307	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850007308	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850007309	dimer interface [polypeptide binding]; other site
690850007310	putative CheW interface [polypeptide binding]; other site
690850007311	oxidoreductase; Validated; Region: PRK05717
690850007312	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
690850007313	NAD(P) binding site [chemical binding]; other site
690850007314	active site
690850007315	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
690850007316	Homeodomain-like domain; Region: HTH_23; pfam13384
690850007317	Homeodomain-like domain; Region: HTH_32; pfam13565
690850007318	DDE superfamily endonuclease; Region: DDE_3; pfam13358
690850007319	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
690850007320	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
690850007321	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
690850007322	active site
690850007323	catalytic site [active]
690850007324	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
690850007325	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
690850007326	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850007327	putative active site [active]
690850007328	heme pocket [chemical binding]; other site
690850007329	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850007330	dimer interface [polypeptide binding]; other site
690850007331	phosphorylation site [posttranslational modification]
690850007332	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850007333	ATP binding site [chemical binding]; other site
690850007334	Mg2+ binding site [ion binding]; other site
690850007335	G-X-G motif; other site
690850007336	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
690850007337	Found in ATP-dependent protease La (LON); Region: LON; smart00464
690850007338	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850007339	Walker A motif; other site
690850007340	ATP binding site [chemical binding]; other site
690850007341	Walker B motif; other site
690850007342	arginine finger; other site
690850007343	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
690850007344	Acylphosphatase; Region: Acylphosphatase; pfam00708
690850007345	DNA repair protein radc; Region: radc; TIGR00608
690850007346	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
690850007347	MPN+ (JAMM) motif; other site
690850007348	Zinc-binding site [ion binding]; other site
690850007349	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
690850007350	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
690850007351	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
690850007352	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
690850007353	HIGH motif; other site
690850007354	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
690850007355	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
690850007356	active site
690850007357	KMSKS motif; other site
690850007358	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
690850007359	tRNA binding surface [nucleotide binding]; other site
690850007360	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
690850007361	putative RNA binding site [nucleotide binding]; other site
690850007362	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
690850007363	homopentamer interface [polypeptide binding]; other site
690850007364	active site
690850007365	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
690850007366	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
690850007367	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
690850007368	dimerization interface [polypeptide binding]; other site
690850007369	active site
690850007370	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
690850007371	Lumazine binding domain; Region: Lum_binding; pfam00677
690850007372	Lumazine binding domain; Region: Lum_binding; pfam00677
690850007373	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
690850007374	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
690850007375	catalytic motif [active]
690850007376	Zn binding site [ion binding]; other site
690850007377	RibD C-terminal domain; Region: RibD_C; cl17279
690850007378	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
690850007379	catalytic motif [active]
690850007380	Zn binding site [ion binding]; other site
690850007381	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
690850007382	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
690850007383	dimer interface [polypeptide binding]; other site
690850007384	active site
690850007385	glycine-pyridoxal phosphate binding site [chemical binding]; other site
690850007386	folate binding site [chemical binding]; other site
690850007387	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
690850007388	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
690850007389	dimer interface [polypeptide binding]; other site
690850007390	active site
690850007391	acyl carrier protein; Provisional; Region: acpP; PRK00982
690850007392	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
690850007393	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
690850007394	NAD(P) binding site [chemical binding]; other site
690850007395	homotetramer interface [polypeptide binding]; other site
690850007396	homodimer interface [polypeptide binding]; other site
690850007397	active site
690850007398	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
690850007399	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
690850007400	dimer interface [polypeptide binding]; other site
690850007401	active site
690850007402	CoA binding pocket [chemical binding]; other site
690850007403	putative phosphate acyltransferase; Provisional; Region: PRK05331
690850007404	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
690850007405	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
690850007406	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
690850007407	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
690850007408	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
690850007409	DNA binding residues [nucleotide binding]
690850007410	dimerization interface [polypeptide binding]; other site
690850007411	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850007412	S-adenosylmethionine binding site [chemical binding]; other site
690850007413	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
690850007414	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850007415	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850007416	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850007417	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850007418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850007419	active site
690850007420	phosphorylation site [posttranslational modification]
690850007421	intermolecular recognition site; other site
690850007422	dimerization interface [polypeptide binding]; other site
690850007423	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850007424	Walker A motif; other site
690850007425	ATP binding site [chemical binding]; other site
690850007426	Walker B motif; other site
690850007427	arginine finger; other site
690850007428	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850007429	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
690850007430	von Willebrand factor type A domain; Region: VWA_2; pfam13519
690850007431	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850007432	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850007433	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850007434	putative active site [active]
690850007435	heme pocket [chemical binding]; other site
690850007436	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850007437	dimer interface [polypeptide binding]; other site
690850007438	phosphorylation site [posttranslational modification]
690850007439	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850007440	ATP binding site [chemical binding]; other site
690850007441	Mg2+ binding site [ion binding]; other site
690850007442	G-X-G motif; other site
690850007443	Response regulator receiver domain; Region: Response_reg; pfam00072
690850007444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850007445	active site
690850007446	phosphorylation site [posttranslational modification]
690850007447	intermolecular recognition site; other site
690850007448	dimerization interface [polypeptide binding]; other site
690850007449	PAS domain; Region: PAS; smart00091
690850007450	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
690850007451	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850007452	phosphorylation site [posttranslational modification]
690850007453	dimer interface [polypeptide binding]; other site
690850007454	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850007455	ATP binding site [chemical binding]; other site
690850007456	Mg2+ binding site [ion binding]; other site
690850007457	G-X-G motif; other site
690850007458	Heavy-metal resistance; Region: Metal_resist; pfam13801
690850007459	dimer interface [polypeptide binding]; other site
690850007460	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
690850007461	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
690850007462	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
690850007463	HIGH motif; other site
690850007464	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
690850007465	active site
690850007466	KMSKS motif; other site
690850007467	EamA-like transporter family; Region: EamA; pfam00892
690850007468	poly(A) polymerase; Region: pcnB; TIGR01942
690850007469	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850007470	Zn2+ binding site [ion binding]; other site
690850007471	Mg2+ binding site [ion binding]; other site
690850007472	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
690850007473	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850007474	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
690850007475	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
690850007476	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850007477	homodimer interface [polypeptide binding]; other site
690850007478	catalytic residue [active]
690850007479	ParB-like nuclease domain; Region: ParBc; pfam02195
690850007480	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
690850007481	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
690850007482	catalytic residues [active]
690850007483	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
690850007484	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850007485	ABC-ATPase subunit interface; other site
690850007486	putative PBP binding loops; other site
690850007487	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
690850007488	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
690850007489	substrate binding pocket [chemical binding]; other site
690850007490	membrane-bound complex binding site; other site
690850007491	hinge residues; other site
690850007492	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
690850007493	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
690850007494	Walker A/P-loop; other site
690850007495	ATP binding site [chemical binding]; other site
690850007496	Q-loop/lid; other site
690850007497	ABC transporter signature motif; other site
690850007498	Walker B; other site
690850007499	D-loop; other site
690850007500	H-loop/switch region; other site
690850007501	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
690850007502	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850007503	dimer interface [polypeptide binding]; other site
690850007504	conserved gate region; other site
690850007505	putative PBP binding loops; other site
690850007506	ABC-ATPase subunit interface; other site
690850007507	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
690850007508	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
690850007509	active site
690850007510	metal binding site [ion binding]; metal-binding site
690850007511	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
690850007512	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690
690850007513	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
690850007514	thymidylate kinase; Validated; Region: tmk; PRK00698
690850007515	TMP-binding site; other site
690850007516	ATP-binding site [chemical binding]; other site
690850007517	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
690850007518	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
690850007519	generic binding surface I; other site
690850007520	generic binding surface II; other site
690850007521	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850007522	Zn2+ binding site [ion binding]; other site
690850007523	Mg2+ binding site [ion binding]; other site
690850007524	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
690850007525	multicopper oxidase; Provisional; Region: PRK10965
690850007526	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
690850007527	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
690850007528	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
690850007529	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
690850007530	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
690850007531	intersubunit interface [polypeptide binding]; other site
690850007532	active site
690850007533	zinc binding site [ion binding]; other site
690850007534	Na+ binding site [ion binding]; other site
690850007535	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
690850007536	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
690850007537	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
690850007538	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850007539	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850007540	putative active site [active]
690850007541	heme pocket [chemical binding]; other site
690850007542	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850007543	putative active site [active]
690850007544	heme pocket [chemical binding]; other site
690850007545	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
690850007546	Histidine kinase; Region: HisKA_2; pfam07568
690850007547	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850007548	ATP binding site [chemical binding]; other site
690850007549	Mg2+ binding site [ion binding]; other site
690850007550	G-X-G motif; other site
690850007551	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
690850007552	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
690850007553	active site
690850007554	PHP Thumb interface [polypeptide binding]; other site
690850007555	metal binding site [ion binding]; metal-binding site
690850007556	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
690850007557	generic binding surface II; other site
690850007558	generic binding surface I; other site
690850007559	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
690850007560	active site
690850007561	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
690850007562	putative active site [active]
690850007563	dimerization interface [polypeptide binding]; other site
690850007564	putative tRNAtyr binding site [nucleotide binding]; other site
690850007565	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
690850007566	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
690850007567	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
690850007568	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
690850007569	anti sigma factor interaction site; other site
690850007570	regulatory phosphorylation site [posttranslational modification]; other site
690850007571	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
690850007572	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
690850007573	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
690850007574	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
690850007575	putative active site [active]
690850007576	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
690850007577	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
690850007578	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
690850007579	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
690850007580	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
690850007581	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
690850007582	Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344
690850007583	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
690850007584	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
690850007585	ribonuclease III; Reviewed; Region: rnc; PRK00102
690850007586	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
690850007587	dimerization interface [polypeptide binding]; other site
690850007588	active site
690850007589	metal binding site [ion binding]; metal-binding site
690850007590	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
690850007591	dsRNA binding site [nucleotide binding]; other site
690850007592	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
690850007593	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
690850007594	DRTGG domain; Region: DRTGG; pfam07085
690850007595	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
690850007596	RNA/DNA hybrid binding site [nucleotide binding]; other site
690850007597	active site
690850007598	TPR repeat; Region: TPR_11; pfam13414
690850007599	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850007600	binding surface
690850007601	TPR motif; other site
690850007602	TPR repeat; Region: TPR_11; pfam13414
690850007603	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
690850007604	putative amphipathic alpha helix; other site
690850007605	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
690850007606	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
690850007607	catalytic triad [active]
690850007608	conserved cis-peptide bond; other site
690850007609	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
690850007610	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
690850007611	active site
690850007612	substrate binding site [chemical binding]; other site
690850007613	metal binding site [ion binding]; metal-binding site
690850007614	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
690850007615	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
690850007616	putative NAD(P) binding site [chemical binding]; other site
690850007617	active site
690850007618	putative substrate binding site [chemical binding]; other site
690850007619	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
690850007620	active site
690850007621	Zn binding site [ion binding]; other site
690850007622	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
690850007623	SnoaL-like domain; Region: SnoaL_3; pfam13474
690850007624	SnoaL-like domain; Region: SnoaL_3; pfam13474
690850007625	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
690850007626	active site
690850007627	adenylosuccinate lyase; Provisional; Region: PRK07492
690850007628	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
690850007629	tetramer interface [polypeptide binding]; other site
690850007630	active site
690850007631	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
690850007632	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
690850007633	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
690850007634	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
690850007635	putative MPT binding site; other site
690850007636	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
690850007637	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
690850007638	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
690850007639	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
690850007640	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
690850007641	HD domain; Region: HD_4; pfam13328
690850007642	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
690850007643	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
690850007644	NlpC/P60 family; Region: NLPC_P60; pfam00877
690850007645	Transglycosylase SLT domain; Region: SLT_2; pfam13406
690850007646	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
690850007647	N-acetyl-D-glucosamine binding site [chemical binding]; other site
690850007648	primosome assembly protein PriA; Provisional; Region: PRK14873
690850007649	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
690850007650	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
690850007651	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
690850007652	active site
690850007653	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
690850007654	O-Antigen ligase; Region: Wzy_C; pfam04932
690850007655	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850007656	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
690850007657	putative ADP-binding pocket [chemical binding]; other site
690850007658	putative glycosyl transferase; Provisional; Region: PRK10018
690850007659	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
690850007660	active site
690850007661	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
690850007662	AIR carboxylase; Region: AIRC; smart01001
690850007663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
690850007664	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850007665	active site
690850007666	phosphorylation site [posttranslational modification]
690850007667	intermolecular recognition site; other site
690850007668	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850007669	Walker A motif; other site
690850007670	ATP binding site [chemical binding]; other site
690850007671	Walker B motif; other site
690850007672	arginine finger; other site
690850007673	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850007674	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
690850007675	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
690850007676	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
690850007677	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
690850007678	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
690850007679	FMN binding site [chemical binding]; other site
690850007680	dimer interface [polypeptide binding]; other site
690850007681	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850007682	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850007683	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850007684	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
690850007685	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
690850007686	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
690850007687	ATP binding site [chemical binding]; other site
690850007688	putative Mg++ binding site [ion binding]; other site
690850007689	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
690850007690	nucleotide binding region [chemical binding]; other site
690850007691	ATP-binding site [chemical binding]; other site
690850007692	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
690850007693	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
690850007694	peptide binding site [polypeptide binding]; other site
690850007695	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
690850007696	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850007697	Zn2+ binding site [ion binding]; other site
690850007698	Mg2+ binding site [ion binding]; other site
690850007699	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
690850007700	synthetase active site [active]
690850007701	NTP binding site [chemical binding]; other site
690850007702	metal binding site [ion binding]; metal-binding site
690850007703	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
690850007704	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
690850007705	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
690850007706	Domain of unknown function DUF20; Region: UPF0118; pfam01594
690850007707	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
690850007708	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
690850007709	putative glutamate synthase subunit beta; Provisional; Region: PRK12770
690850007710	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
690850007711	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
690850007712	transketolase; Reviewed; Region: PRK12753
690850007713	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
690850007714	TPP-binding site [chemical binding]; other site
690850007715	dimer interface [polypeptide binding]; other site
690850007716	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
690850007717	PYR/PP interface [polypeptide binding]; other site
690850007718	dimer interface [polypeptide binding]; other site
690850007719	TPP binding site [chemical binding]; other site
690850007720	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
690850007721	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
690850007722	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
690850007723	catalytic residues [active]
690850007724	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
690850007725	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
690850007726	Walker A/P-loop; other site
690850007727	ATP binding site [chemical binding]; other site
690850007728	Q-loop/lid; other site
690850007729	ABC transporter signature motif; other site
690850007730	Walker B; other site
690850007731	D-loop; other site
690850007732	H-loop/switch region; other site
690850007733	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
690850007734	PhoU domain; Region: PhoU; pfam01895
690850007735	PhoU domain; Region: PhoU; pfam01895
690850007736	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
690850007737	putative active site [active]
690850007738	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
690850007739	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
690850007740	ATP-grasp domain; Region: ATP-grasp_4; cl17255
690850007741	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
690850007742	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
690850007743	Response regulator receiver domain; Region: Response_reg; pfam00072
690850007744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850007745	active site
690850007746	phosphorylation site [posttranslational modification]
690850007747	intermolecular recognition site; other site
690850007748	dimerization interface [polypeptide binding]; other site
690850007749	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850007750	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
690850007751	dimer interface [polypeptide binding]; other site
690850007752	phosphorylation site [posttranslational modification]
690850007753	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850007754	ATP binding site [chemical binding]; other site
690850007755	Mg2+ binding site [ion binding]; other site
690850007756	G-X-G motif; other site
690850007757	Response regulator receiver domain; Region: Response_reg; pfam00072
690850007758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850007759	active site
690850007760	phosphorylation site [posttranslational modification]
690850007761	intermolecular recognition site; other site
690850007762	dimerization interface [polypeptide binding]; other site
690850007763	Response regulator receiver domain; Region: Response_reg; pfam00072
690850007764	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850007765	active site
690850007766	phosphorylation site [posttranslational modification]
690850007767	intermolecular recognition site; other site
690850007768	dimerization interface [polypeptide binding]; other site
690850007769	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850007770	dimer interface [polypeptide binding]; other site
690850007771	phosphorylation site [posttranslational modification]
690850007772	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850007773	ATP binding site [chemical binding]; other site
690850007774	Mg2+ binding site [ion binding]; other site
690850007775	G-X-G motif; other site
690850007776	PAS domain; Region: PAS; smart00091
690850007777	PAS domain S-box; Region: sensory_box; TIGR00229
690850007778	putative active site [active]
690850007779	heme pocket [chemical binding]; other site
690850007780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850007781	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
690850007782	Walker A motif; other site
690850007783	ATP binding site [chemical binding]; other site
690850007784	Walker B motif; other site
690850007785	arginine finger; other site
690850007786	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
690850007787	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
690850007788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850007789	Walker A motif; other site
690850007790	ATP binding site [chemical binding]; other site
690850007791	Walker B motif; other site
690850007792	arginine finger; other site
690850007793	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850007794	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
690850007795	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850007796	dimer interface [polypeptide binding]; other site
690850007797	conserved gate region; other site
690850007798	putative PBP binding loops; other site
690850007799	ABC-ATPase subunit interface; other site
690850007800	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850007801	dimer interface [polypeptide binding]; other site
690850007802	conserved gate region; other site
690850007803	putative PBP binding loops; other site
690850007804	ABC-ATPase subunit interface; other site
690850007805	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
690850007806	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850007807	Walker A/P-loop; other site
690850007808	ATP binding site [chemical binding]; other site
690850007809	Q-loop/lid; other site
690850007810	ABC transporter signature motif; other site
690850007811	Walker B; other site
690850007812	D-loop; other site
690850007813	H-loop/switch region; other site
690850007814	TOBE domain; Region: TOBE_2; pfam08402
690850007815	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
690850007816	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
690850007817	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
690850007818	dimer interface [polypeptide binding]; other site
690850007819	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
690850007820	Domain of unknown function (DUF2382); Region: DUF2382; cl01590
690850007821	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
690850007822	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
690850007823	active site
690850007824	HIGH motif; other site
690850007825	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
690850007826	KMSKS motif; other site
690850007827	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
690850007828	tRNA binding surface [nucleotide binding]; other site
690850007829	anticodon binding site; other site
690850007830	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
690850007831	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
690850007832	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
690850007833	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
690850007834	Soluble P-type ATPase [General function prediction only]; Region: COG4087
690850007835	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
690850007836	putative inner membrane protein; Provisional; Region: PRK11099
690850007837	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
690850007838	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
690850007839	substrate binding site; other site
690850007840	dimer interface; other site
690850007841	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
690850007842	homotrimer interaction site [polypeptide binding]; other site
690850007843	zinc binding site [ion binding]; other site
690850007844	CDP-binding sites; other site
690850007845	Right handed beta helix region; Region: Beta_helix; pfam13229
690850007846	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
690850007847	classical (c) SDRs; Region: SDR_c; cd05233
690850007848	NAD(P) binding site [chemical binding]; other site
690850007849	active site
690850007850	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
690850007851	Putative zinc ribbon domain; Region: DUF164; pfam02591
690850007852	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
690850007853	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
690850007854	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
690850007855	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
690850007856	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
690850007857	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
690850007858	GAF domain; Region: GAF; pfam01590
690850007859	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850007860	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850007861	metal binding site [ion binding]; metal-binding site
690850007862	active site
690850007863	I-site; other site
690850007864	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850007865	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
690850007866	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850007867	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850007868	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850007869	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850007870	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850007871	Ferritin-like domain; Region: Ferritin; pfam00210
690850007872	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
690850007873	dinuclear metal binding motif [ion binding]; other site
690850007874	HPP family; Region: HPP; pfam04982
690850007875	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
690850007876	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850007877	S-adenosylmethionine binding site [chemical binding]; other site
690850007878	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
690850007879	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
690850007880	tandem repeat interface [polypeptide binding]; other site
690850007881	oligomer interface [polypeptide binding]; other site
690850007882	active site residues [active]
690850007883	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
690850007884	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
690850007885	Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973
690850007886	catalytic residues [active]
690850007887	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
690850007888	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
690850007889	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
690850007890	PAS domain; Region: PAS; smart00091
690850007891	PAS fold; Region: PAS_4; pfam08448
690850007892	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
690850007893	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
690850007894	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850007895	PAS domain; Region: PAS_9; pfam13426
690850007896	putative active site [active]
690850007897	heme pocket [chemical binding]; other site
690850007898	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
690850007899	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850007900	Walker A motif; other site
690850007901	ATP binding site [chemical binding]; other site
690850007902	Walker B motif; other site
690850007903	arginine finger; other site
690850007904	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850007905	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
690850007906	EF-hand domain pair; Region: EF_hand_5; pfam13499
690850007907	Ca2+ binding site [ion binding]; other site
690850007908	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
690850007909	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
690850007910	active site
690850007911	motif I; other site
690850007912	motif II; other site
690850007913	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
690850007914	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
690850007915	trimer interface [polypeptide binding]; other site
690850007916	active site
690850007917	substrate binding site [chemical binding]; other site
690850007918	CoA binding site [chemical binding]; other site
690850007919	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
690850007920	isocitrate dehydrogenase; Validated; Region: PRK07362
690850007921	ornithine cyclodeaminase; Validated; Region: PRK07340
690850007922	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
690850007923	Protein of unknown function (DUF554); Region: DUF554; pfam04474
690850007924	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
690850007925	putative metal binding site [ion binding]; other site
690850007926	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
690850007927	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850007928	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850007929	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850007930	BRO family, N-terminal domain; Region: Bro-N; smart01040
690850007931	Prophage antirepressor [Transcription]; Region: COG3617
690850007932	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
690850007933	Catalytic site [active]
690850007934	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
690850007935	non-specific DNA binding site [nucleotide binding]; other site
690850007936	salt bridge; other site
690850007937	sequence-specific DNA binding site [nucleotide binding]; other site
690850007938	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
690850007939	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
690850007940	Phage Tail Collar Domain; Region: Collar; pfam07484
690850007941	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
690850007942	Cache domain; Region: Cache_1; pfam02743
690850007943	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850007944	dimerization interface [polypeptide binding]; other site
690850007945	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850007946	dimer interface [polypeptide binding]; other site
690850007947	putative CheW interface [polypeptide binding]; other site
690850007948	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
690850007949	putative CheA interaction surface; other site
690850007950	Predicted integral membrane protein [Function unknown]; Region: COG5652
690850007951	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
690850007952	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
690850007953	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
690850007954	non-specific DNA binding site [nucleotide binding]; other site
690850007955	salt bridge; other site
690850007956	sequence-specific DNA binding site [nucleotide binding]; other site
690850007957	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
690850007958	hypothetical protein; Provisional; Region: PRK06850
690850007959	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
690850007960	Active Sites [active]
690850007961	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
690850007962	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850007963	Walker A/P-loop; other site
690850007964	ATP binding site [chemical binding]; other site
690850007965	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850007966	ABC transporter signature motif; other site
690850007967	Walker B; other site
690850007968	D-loop; other site
690850007969	H-loop/switch region; other site
690850007970	Domain of unknown function (DUF1832); Region: DUF1832; pfam08870
690850007971	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
690850007972	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
690850007973	active site
690850007974	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
690850007975	non-specific DNA binding site [nucleotide binding]; other site
690850007976	salt bridge; other site
690850007977	sequence-specific DNA binding site [nucleotide binding]; other site
690850007978	Predicted transcriptional regulator [Transcription]; Region: COG2932
690850007979	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
690850007980	Catalytic site [active]
690850007981	PAS domain; Region: PAS_9; pfam13426
690850007982	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
690850007983	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850007984	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850007985	putative active site [active]
690850007986	heme pocket [chemical binding]; other site
690850007987	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850007988	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850007989	putative active site [active]
690850007990	heme pocket [chemical binding]; other site
690850007991	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850007992	putative active site [active]
690850007993	heme pocket [chemical binding]; other site
690850007994	GAF domain; Region: GAF_2; pfam13185
690850007995	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850007996	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850007997	dimer interface [polypeptide binding]; other site
690850007998	phosphorylation site [posttranslational modification]
690850007999	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850008000	ATP binding site [chemical binding]; other site
690850008001	Mg2+ binding site [ion binding]; other site
690850008002	G-X-G motif; other site
690850008003	Response regulator receiver domain; Region: Response_reg; pfam00072
690850008004	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850008005	active site
690850008006	phosphorylation site [posttranslational modification]
690850008007	intermolecular recognition site; other site
690850008008	dimerization interface [polypeptide binding]; other site
690850008009	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
690850008010	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
690850008011	Catalytic site [active]
690850008012	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
690850008013	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
690850008014	active site
690850008015	DNA binding site [nucleotide binding]
690850008016	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
690850008017	Protein of unknown function (DUF497); Region: DUF497; cl01108
690850008018	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
690850008019	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
690850008020	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
690850008021	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
690850008022	putative CheA interaction surface; other site
690850008023	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
690850008024	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
690850008025	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
690850008026	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850008027	dimerization interface [polypeptide binding]; other site
690850008028	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850008029	dimer interface [polypeptide binding]; other site
690850008030	putative CheW interface [polypeptide binding]; other site
690850008031	Cache domain; Region: Cache_1; pfam02743
690850008032	PAS fold; Region: PAS_4; pfam08448
690850008033	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850008034	putative active site [active]
690850008035	heme pocket [chemical binding]; other site
690850008036	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850008037	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850008038	dimer interface [polypeptide binding]; other site
690850008039	putative CheW interface [polypeptide binding]; other site
690850008040	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
690850008041	metal-binding site [ion binding]
690850008042	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
690850008043	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
690850008044	metal-binding site [ion binding]
690850008045	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
690850008046	Soluble P-type ATPase [General function prediction only]; Region: COG4087
690850008047	Cysteine-rich small domain; Region: zf-like; cl00946
690850008048	Response regulator receiver domain; Region: Response_reg; pfam00072
690850008049	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850008050	active site
690850008051	phosphorylation site [posttranslational modification]
690850008052	intermolecular recognition site; other site
690850008053	dimerization interface [polypeptide binding]; other site
690850008054	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
690850008055	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850008056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850008057	active site
690850008058	phosphorylation site [posttranslational modification]
690850008059	intermolecular recognition site; other site
690850008060	dimerization interface [polypeptide binding]; other site
690850008061	PAS domain S-box; Region: sensory_box; TIGR00229
690850008062	PAS domain; Region: PAS; smart00091
690850008063	PAS fold; Region: PAS_4; pfam08448
690850008064	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850008065	putative active site [active]
690850008066	heme pocket [chemical binding]; other site
690850008067	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
690850008068	DinB superfamily; Region: DinB_2; pfam12867
690850008069	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
690850008070	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
690850008071	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
690850008072	catalytic loop [active]
690850008073	iron binding site [ion binding]; other site
690850008074	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
690850008075	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
690850008076	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
690850008077	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
690850008078	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
690850008079	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
690850008080	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850008081	Coenzyme A binding pocket [chemical binding]; other site
690850008082	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
690850008083	Sulfatase; Region: Sulfatase; pfam00884
690850008084	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
690850008085	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850008086	FeS/SAM binding site; other site
690850008087	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
690850008088	SEC-C motif; Region: SEC-C; pfam02810
690850008089	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
690850008090	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
690850008091	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
690850008092	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
690850008093	putative active site [active]
690850008094	catalytic site [active]
690850008095	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
690850008096	PLD-like domain; Region: PLDc_2; pfam13091
690850008097	putative active site [active]
690850008098	catalytic site [active]
690850008099	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
690850008100	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850008101	Walker A motif; other site
690850008102	ATP binding site [chemical binding]; other site
690850008103	Walker B motif; other site
690850008104	arginine finger; other site
690850008105	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
690850008106	BON domain; Region: BON; pfam04972
690850008107	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
690850008108	Mechanosensitive ion channel; Region: MS_channel; pfam00924
690850008109	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
690850008110	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
690850008111	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
690850008112	putative active site; other site
690850008113	catalytic residue [active]
690850008114	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
690850008115	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
690850008116	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
690850008117	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850008118	dimer interface [polypeptide binding]; other site
690850008119	conserved gate region; other site
690850008120	putative PBP binding loops; other site
690850008121	ABC-ATPase subunit interface; other site
690850008122	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
690850008123	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
690850008124	Walker A/P-loop; other site
690850008125	ATP binding site [chemical binding]; other site
690850008126	Q-loop/lid; other site
690850008127	ABC transporter signature motif; other site
690850008128	Walker B; other site
690850008129	D-loop; other site
690850008130	H-loop/switch region; other site
690850008131	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
690850008132	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
690850008133	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850008134	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850008135	active site
690850008136	phosphorylation site [posttranslational modification]
690850008137	intermolecular recognition site; other site
690850008138	dimerization interface [polypeptide binding]; other site
690850008139	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850008140	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850008141	dimer interface [polypeptide binding]; other site
690850008142	phosphorylation site [posttranslational modification]
690850008143	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850008144	ATP binding site [chemical binding]; other site
690850008145	Mg2+ binding site [ion binding]; other site
690850008146	G-X-G motif; other site
690850008147	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850008148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850008149	active site
690850008150	phosphorylation site [posttranslational modification]
690850008151	intermolecular recognition site; other site
690850008152	dimerization interface [polypeptide binding]; other site
690850008153	CHASE4 domain; Region: CHASE4; pfam05228
690850008154	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850008155	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850008156	dimerization interface [polypeptide binding]; other site
690850008157	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850008158	ATP binding site [chemical binding]; other site
690850008159	Mg2+ binding site [ion binding]; other site
690850008160	G-X-G motif; other site
690850008161	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
690850008162	TadE-like protein; Region: TadE; pfam07811
690850008163	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850008164	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850008165	active site
690850008166	phosphorylation site [posttranslational modification]
690850008167	intermolecular recognition site; other site
690850008168	dimerization interface [polypeptide binding]; other site
690850008169	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850008170	Walker A motif; other site
690850008171	ATP binding site [chemical binding]; other site
690850008172	Walker B motif; other site
690850008173	arginine finger; other site
690850008174	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850008175	HDOD domain; Region: HDOD; pfam08668
690850008176	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850008177	Zn2+ binding site [ion binding]; other site
690850008178	Mg2+ binding site [ion binding]; other site
690850008179	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850008180	dimerization interface [polypeptide binding]; other site
690850008181	PAS domain; Region: PAS; smart00091
690850008182	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850008183	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850008184	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850008185	putative active site [active]
690850008186	heme pocket [chemical binding]; other site
690850008187	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850008188	dimer interface [polypeptide binding]; other site
690850008189	phosphorylation site [posttranslational modification]
690850008190	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850008191	ATP binding site [chemical binding]; other site
690850008192	Mg2+ binding site [ion binding]; other site
690850008193	G-X-G motif; other site
690850008194	Response regulator receiver domain; Region: Response_reg; pfam00072
690850008195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850008196	active site
690850008197	phosphorylation site [posttranslational modification]
690850008198	intermolecular recognition site; other site
690850008199	dimerization interface [polypeptide binding]; other site
690850008200	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
690850008201	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
690850008202	substrate binding pocket [chemical binding]; other site
690850008203	membrane-bound complex binding site; other site
690850008204	hinge residues; other site
690850008205	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
690850008206	NMT1/THI5 like; Region: NMT1; pfam09084
690850008207	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
690850008208	membrane-bound complex binding site; other site
690850008209	hinge residues; other site
690850008210	PAS domain S-box; Region: sensory_box; TIGR00229
690850008211	PAS domain S-box; Region: sensory_box; TIGR00229
690850008212	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850008213	putative active site [active]
690850008214	heme pocket [chemical binding]; other site
690850008215	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850008216	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850008217	putative active site [active]
690850008218	heme pocket [chemical binding]; other site
690850008219	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850008220	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850008221	putative active site [active]
690850008222	heme pocket [chemical binding]; other site
690850008223	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850008224	dimer interface [polypeptide binding]; other site
690850008225	phosphorylation site [posttranslational modification]
690850008226	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850008227	ATP binding site [chemical binding]; other site
690850008228	Mg2+ binding site [ion binding]; other site
690850008229	G-X-G motif; other site
690850008230	Response regulator receiver domain; Region: Response_reg; pfam00072
690850008231	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850008232	active site
690850008233	phosphorylation site [posttranslational modification]
690850008234	intermolecular recognition site; other site
690850008235	dimerization interface [polypeptide binding]; other site
690850008236	Predicted membrane protein [Function unknown]; Region: COG4541
690850008237	AzlC protein; Region: AzlC; cl00570
690850008238	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
690850008239	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
690850008240	DNA-binding site [nucleotide binding]; DNA binding site
690850008241	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
690850008242	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850008243	homodimer interface [polypeptide binding]; other site
690850008244	catalytic residue [active]
690850008245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850008246	S-adenosylmethionine binding site [chemical binding]; other site
690850008247	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
690850008248	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
690850008249	active site
690850008250	Radical SAM superfamily; Region: Radical_SAM; pfam04055
690850008251	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
690850008252	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
690850008253	active site
690850008254	Protein of unknown function (DUF2914); Region: DUF2914; pfam11141
690850008255	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
690850008256	catalytic core [active]
690850008257	EamA-like transporter family; Region: EamA; pfam00892
690850008258	EamA-like transporter family; Region: EamA; pfam00892
690850008259	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
690850008260	N-acetyl-D-glucosamine binding site [chemical binding]; other site
690850008261	catalytic residue [active]
690850008262	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
690850008263	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
690850008264	FtsX-like permease family; Region: FtsX; pfam02687
690850008265	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
690850008266	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
690850008267	Walker A/P-loop; other site
690850008268	ATP binding site [chemical binding]; other site
690850008269	Q-loop/lid; other site
690850008270	ABC transporter signature motif; other site
690850008271	Walker B; other site
690850008272	D-loop; other site
690850008273	H-loop/switch region; other site
690850008274	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
690850008275	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
690850008276	ABC-2 type transporter; Region: ABC2_membrane; cl17235
690850008277	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
690850008278	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
690850008279	Walker A/P-loop; other site
690850008280	ATP binding site [chemical binding]; other site
690850008281	Q-loop/lid; other site
690850008282	ABC transporter signature motif; other site
690850008283	Walker B; other site
690850008284	D-loop; other site
690850008285	H-loop/switch region; other site
690850008286	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
690850008287	dimerization interface [polypeptide binding]; other site
690850008288	putative DNA binding site [nucleotide binding]; other site
690850008289	putative Zn2+ binding site [ion binding]; other site
690850008290	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
690850008291	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
690850008292	active site
690850008293	metal binding site [ion binding]; metal-binding site
690850008294	Hemerythrin-like domain; Region: Hr-like; cd12108
690850008295	Fe binding site [ion binding]; other site
690850008296	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
690850008297	non-heme iron binding site [ion binding]; other site
690850008298	dimer interface [polypeptide binding]; other site
690850008299	Protein of unknown function (DUF330); Region: DUF330; pfam03886
690850008300	mce related protein; Region: MCE; pfam02470
690850008301	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
690850008302	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
690850008303	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850008304	Walker A/P-loop; other site
690850008305	ATP binding site [chemical binding]; other site
690850008306	Q-loop/lid; other site
690850008307	ABC transporter signature motif; other site
690850008308	Walker B; other site
690850008309	D-loop; other site
690850008310	H-loop/switch region; other site
690850008311	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
690850008312	anti sigma factor interaction site; other site
690850008313	regulatory phosphorylation site [posttranslational modification]; other site
690850008314	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
690850008315	Permease; Region: Permease; pfam02405
690850008316	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
690850008317	active site
690850008318	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
690850008319	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
690850008320	Protein of unknown function, DUF488; Region: DUF488; cl01246
690850008321	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
690850008322	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
690850008323	substrate binding site [chemical binding]; other site
690850008324	hexamer interface [polypeptide binding]; other site
690850008325	metal binding site [ion binding]; metal-binding site
690850008326	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
690850008327	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
690850008328	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850008329	FeS/SAM binding site; other site
690850008330	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
690850008331	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
690850008332	dimer interface [polypeptide binding]; other site
690850008333	active site
690850008334	Schiff base residues; other site
690850008335	HEPN domain; Region: HEPN; pfam05168
690850008336	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
690850008337	metal binding triad [ion binding]; metal-binding site
690850008338	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
690850008339	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850008340	FeS/SAM binding site; other site
690850008341	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
690850008342	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
690850008343	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG2881
690850008344	Predicted amidohydrolase [General function prediction only]; Region: COG0388
690850008345	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
690850008346	active site
690850008347	catalytic triad [active]
690850008348	dimer interface [polypeptide binding]; other site
690850008349	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
690850008350	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
690850008351	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850008352	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
690850008353	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
690850008354	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
690850008355	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
690850008356	flagellin; Provisional; Region: PRK12802
690850008357	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
690850008358	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
690850008359	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
690850008360	Glycoprotease family; Region: Peptidase_M22; pfam00814
690850008361	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
690850008362	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
690850008363	active site
690850008364	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
690850008365	protein binding site [polypeptide binding]; other site
690850008366	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
690850008367	putative substrate binding region [chemical binding]; other site
690850008368	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
690850008369	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
690850008370	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
690850008371	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
690850008372	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
690850008373	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
690850008374	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
690850008375	Rubredoxin; Region: Rubredoxin; pfam00301
690850008376	iron binding site [ion binding]; other site
690850008377	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
690850008378	Active_site [active]
690850008379	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
690850008380	Bacterial SH3 domain; Region: SH3_3; pfam08239
690850008381	homoserine dehydrogenase; Provisional; Region: PRK06349
690850008382	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
690850008383	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
690850008384	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
690850008385	aminotransferase; Validated; Region: PRK08175
690850008386	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
690850008387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850008388	homodimer interface [polypeptide binding]; other site
690850008389	catalytic residue [active]
690850008390	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
690850008391	Ligand Binding Site [chemical binding]; other site
690850008392	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
690850008393	putative active site [active]
690850008394	TPR repeat; Region: TPR_11; pfam13414
690850008395	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850008396	binding surface
690850008397	TPR motif; other site
690850008398	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
690850008399	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
690850008400	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
690850008401	HlyD family secretion protein; Region: HlyD_3; pfam13437
690850008402	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
690850008403	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
690850008404	dimer interface [polypeptide binding]; other site
690850008405	ssDNA binding site [nucleotide binding]; other site
690850008406	tetramer (dimer of dimers) interface [polypeptide binding]; other site
690850008407	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
690850008408	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
690850008409	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
690850008410	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850008411	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850008412	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
690850008413	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850008414	Methyltransferase domain; Region: Methyltransf_31; pfam13847
690850008415	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850008416	S-adenosylmethionine binding site [chemical binding]; other site
690850008417	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
690850008418	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
690850008419	PYR/PP interface [polypeptide binding]; other site
690850008420	dimer interface [polypeptide binding]; other site
690850008421	TPP binding site [chemical binding]; other site
690850008422	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
690850008423	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
690850008424	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
690850008425	tetramer interface [polypeptide binding]; other site
690850008426	TPP-binding site [chemical binding]; other site
690850008427	heterodimer interface [polypeptide binding]; other site
690850008428	phosphorylation loop region [posttranslational modification]
690850008429	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
690850008430	Peptidase family M23; Region: Peptidase_M23; pfam01551
690850008431	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
690850008432	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
690850008433	Ligand Binding Site [chemical binding]; other site
690850008434	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
690850008435	chaperone protein DnaJ; Provisional; Region: PRK14301
690850008436	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
690850008437	HSP70 interaction site [polypeptide binding]; other site
690850008438	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
690850008439	substrate binding site [polypeptide binding]; other site
690850008440	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
690850008441	Zn binding sites [ion binding]; other site
690850008442	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
690850008443	dimer interface [polypeptide binding]; other site
690850008444	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
690850008445	trimer interface [polypeptide binding]; other site
690850008446	dimer interface [polypeptide binding]; other site
690850008447	putative active site [active]
690850008448	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
690850008449	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
690850008450	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
690850008451	active site
690850008452	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
690850008453	EamA-like transporter family; Region: EamA; cl17759
690850008454	EamA-like transporter family; Region: EamA; pfam00892
690850008455	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
690850008456	homohexameric interface [polypeptide binding]; other site
690850008457	nucleotide binding site [chemical binding]; other site
690850008458	N-acetyl-L-glutamate binding site [chemical binding]; other site
690850008459	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
690850008460	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850008461	Walker A motif; other site
690850008462	ATP binding site [chemical binding]; other site
690850008463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850008464	Walker B motif; other site
690850008465	arginine finger; other site
690850008466	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
690850008467	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
690850008468	active site
690850008469	HslU subunit interaction site [polypeptide binding]; other site
690850008470	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
690850008471	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
690850008472	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
690850008473	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
690850008474	Peptidase family M48; Region: Peptidase_M48; pfam01435
690850008475	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850008476	binding surface
690850008477	TPR motif; other site
690850008478	transcription termination factor Rho; Provisional; Region: rho; PRK09376
690850008479	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
690850008480	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
690850008481	RNA binding site [nucleotide binding]; other site
690850008482	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
690850008483	multimer interface [polypeptide binding]; other site
690850008484	Walker A motif; other site
690850008485	ATP binding site [chemical binding]; other site
690850008486	Walker B motif; other site
690850008487	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
690850008488	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
690850008489	putative active site [active]
690850008490	catalytic residue [active]
690850008491	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
690850008492	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
690850008493	5S rRNA interface [nucleotide binding]; other site
690850008494	CTC domain interface [polypeptide binding]; other site
690850008495	L16 interface [polypeptide binding]; other site
690850008496	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
690850008497	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
690850008498	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
690850008499	active site
690850008500	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
690850008501	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
690850008502	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
690850008503	protein binding site [polypeptide binding]; other site
690850008504	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
690850008505	protein binding site [polypeptide binding]; other site
690850008506	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
690850008507	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
690850008508	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
690850008509	dihydrodipicolinate synthase; Region: dapA; TIGR00674
690850008510	dimer interface [polypeptide binding]; other site
690850008511	active site
690850008512	catalytic residue [active]
690850008513	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
690850008514	metal binding site [ion binding]; metal-binding site
690850008515	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
690850008516	IHF - DNA interface [nucleotide binding]; other site
690850008517	IHF dimer interface [polypeptide binding]; other site
690850008518	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
690850008519	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
690850008520	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850008521	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850008522	metal binding site [ion binding]; metal-binding site
690850008523	active site
690850008524	I-site; other site
690850008525	peptide chain release factor 2; Validated; Region: prfB; PRK00578
690850008526	This domain is found in peptide chain release factors; Region: PCRF; smart00937
690850008527	RF-1 domain; Region: RF-1; pfam00472
690850008528	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
690850008529	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
690850008530	putative active site [active]
690850008531	catalytic triad [active]
690850008532	putative dimer interface [polypeptide binding]; other site
690850008533	FOG: CBS domain [General function prediction only]; Region: COG0517
690850008534	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
690850008535	Transporter associated domain; Region: CorC_HlyC; smart01091
690850008536	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
690850008537	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
690850008538	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
690850008539	diaminopimelate aminotransferase; Provisional; Region: PRK13983
690850008540	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650
690850008541	metal binding site [ion binding]; metal-binding site
690850008542	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
690850008543	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
690850008544	active site
690850008545	putative substrate binding pocket [chemical binding]; other site
690850008546	Esterase/lipase [General function prediction only]; Region: COG1647
690850008547	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
690850008548	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
690850008549	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
690850008550	TrkA-N domain; Region: TrkA_N; pfam02254
690850008551	TrkA-C domain; Region: TrkA_C; pfam02080
690850008552	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
690850008553	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
690850008554	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
690850008555	active site
690850008556	catalytic residues [active]
690850008557	metal binding site [ion binding]; metal-binding site
690850008558	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
690850008559	aspartate kinase; Reviewed; Region: PRK06635
690850008560	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
690850008561	putative nucleotide binding site [chemical binding]; other site
690850008562	putative catalytic residues [active]
690850008563	putative Mg ion binding site [ion binding]; other site
690850008564	putative aspartate binding site [chemical binding]; other site
690850008565	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
690850008566	putative allosteric regulatory site; other site
690850008567	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
690850008568	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
690850008569	FOG: CBS domain [General function prediction only]; Region: COG0517
690850008570	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
690850008571	putative carbohydrate kinase; Provisional; Region: PRK10565
690850008572	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
690850008573	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
690850008574	putative substrate binding site [chemical binding]; other site
690850008575	putative ATP binding site [chemical binding]; other site
690850008576	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14657
690850008577	pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265
690850008578	active site
690850008579	hydrophilic channel; other site
690850008580	dimerization interface [polypeptide binding]; other site
690850008581	catalytic residues [active]
690850008582	active site lid [active]
690850008583	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
690850008584	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
690850008585	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
690850008586	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
690850008587	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
690850008588	putative CheA interaction surface; other site
690850008589	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
690850008590	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
690850008591	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
690850008592	ATP binding site [chemical binding]; other site
690850008593	putative Mg++ binding site [ion binding]; other site
690850008594	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
690850008595	nucleotide binding region [chemical binding]; other site
690850008596	ATP-binding site [chemical binding]; other site
690850008597	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
690850008598	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
690850008599	SurA N-terminal domain; Region: SurA_N; pfam09312
690850008600	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
690850008601	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
690850008602	Helix-turn-helix domain; Region: HTH_25; pfam13413
690850008603	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
690850008604	Recombination protein O N terminal; Region: RecO_N; pfam11967
690850008605	DNA repair protein RecO; Region: reco; TIGR00613
690850008606	Recombination protein O C terminal; Region: RecO_C; pfam02565
690850008607	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
690850008608	dimer interface [polypeptide binding]; other site
690850008609	motif 1; other site
690850008610	active site
690850008611	motif 2; other site
690850008612	motif 3; other site
690850008613	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
690850008614	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
690850008615	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
690850008616	Sporulation related domain; Region: SPOR; pfam05036
690850008617	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
690850008618	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
690850008619	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
690850008620	active site
690850008621	HIGH motif; other site
690850008622	KMSK motif region; other site
690850008623	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
690850008624	tRNA binding surface [nucleotide binding]; other site
690850008625	anticodon binding site; other site
690850008626	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
690850008627	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
690850008628	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
690850008629	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
690850008630	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
690850008631	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850008632	dimerization interface [polypeptide binding]; other site
690850008633	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
690850008634	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850008635	putative active site [active]
690850008636	heme pocket [chemical binding]; other site
690850008637	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850008638	dimer interface [polypeptide binding]; other site
690850008639	phosphorylation site [posttranslational modification]
690850008640	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850008641	ATP binding site [chemical binding]; other site
690850008642	Mg2+ binding site [ion binding]; other site
690850008643	G-X-G motif; other site
690850008644	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
690850008645	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
690850008646	putative NAD(P) binding site [chemical binding]; other site
690850008647	putative active site [active]
690850008648	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850008649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850008650	active site
690850008651	phosphorylation site [posttranslational modification]
690850008652	intermolecular recognition site; other site
690850008653	dimerization interface [polypeptide binding]; other site
690850008654	PAS domain S-box; Region: sensory_box; TIGR00229
690850008655	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850008656	putative active site [active]
690850008657	heme pocket [chemical binding]; other site
690850008658	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
690850008659	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850008660	Zn2+ binding site [ion binding]; other site
690850008661	Mg2+ binding site [ion binding]; other site
690850008662	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850008663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850008664	active site
690850008665	phosphorylation site [posttranslational modification]
690850008666	intermolecular recognition site; other site
690850008667	dimerization interface [polypeptide binding]; other site
690850008668	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850008669	Walker A motif; other site
690850008670	ATP binding site [chemical binding]; other site
690850008671	Walker B motif; other site
690850008672	arginine finger; other site
690850008673	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850008674	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
690850008675	putative catalytic site [active]
690850008676	putative metal binding site [ion binding]; other site
690850008677	putative phosphate binding site [ion binding]; other site
690850008678	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
690850008679	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
690850008680	active site
690850008681	metal binding site [ion binding]; metal-binding site
690850008682	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
690850008683	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
690850008684	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
690850008685	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
690850008686	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850008687	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850008688	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850008689	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
690850008690	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
690850008691	dimer interface [polypeptide binding]; other site
690850008692	putative anticodon binding site; other site
690850008693	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
690850008694	motif 1; other site
690850008695	active site
690850008696	motif 2; other site
690850008697	motif 3; other site
690850008698	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
690850008699	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
690850008700	FtsX-like permease family; Region: FtsX; pfam02687
690850008701	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
690850008702	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
690850008703	Walker A/P-loop; other site
690850008704	ATP binding site [chemical binding]; other site
690850008705	Q-loop/lid; other site
690850008706	ABC transporter signature motif; other site
690850008707	Walker B; other site
690850008708	D-loop; other site
690850008709	H-loop/switch region; other site
690850008710	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
690850008711	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
690850008712	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
690850008713	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
690850008714	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
690850008715	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
690850008716	Surface antigen; Region: Bac_surface_Ag; pfam01103
690850008717	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
690850008718	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
690850008719	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
690850008720	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
690850008721	trimer interface [polypeptide binding]; other site
690850008722	active site
690850008723	UDP-GlcNAc binding site [chemical binding]; other site
690850008724	lipid binding site [chemical binding]; lipid-binding site
690850008725	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
690850008726	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
690850008727	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
690850008728	active site
690850008729	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
690850008730	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
690850008731	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
690850008732	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
690850008733	active site
690850008734	HIGH motif; other site
690850008735	KMSKS motif; other site
690850008736	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
690850008737	anticodon binding site; other site
690850008738	tRNA binding surface [nucleotide binding]; other site
690850008739	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
690850008740	dimer interface [polypeptide binding]; other site
690850008741	putative tRNA-binding site [nucleotide binding]; other site
690850008742	Ferredoxin [Energy production and conversion]; Region: COG1146
690850008743	4Fe-4S binding domain; Region: Fer4; pfam00037
690850008744	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
690850008745	FMN binding site [chemical binding]; other site
690850008746	dimer interface [polypeptide binding]; other site
690850008747	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
690850008748	adenylate kinase; Provisional; Region: PRK14529
690850008749	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
690850008750	AMP-binding site [chemical binding]; other site
690850008751	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
690850008752	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
690850008753	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
690850008754	Ligand Binding Site [chemical binding]; other site
690850008755	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
690850008756	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
690850008757	putative ADP-binding pocket [chemical binding]; other site
690850008758	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850008759	CHASE2 domain; Region: CHASE2; pfam05226
690850008760	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
690850008761	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
690850008762	cyclase homology domain; Region: CHD; cd07302
690850008763	nucleotidyl binding site; other site
690850008764	metal binding site [ion binding]; metal-binding site
690850008765	dimer interface [polypeptide binding]; other site
690850008766	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
690850008767	FecR protein; Region: FecR; pfam04773
690850008768	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
690850008769	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
690850008770	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
690850008771	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850008772	Walker A/P-loop; other site
690850008773	ATP binding site [chemical binding]; other site
690850008774	Q-loop/lid; other site
690850008775	ABC transporter signature motif; other site
690850008776	Walker B; other site
690850008777	D-loop; other site
690850008778	H-loop/switch region; other site
690850008779	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
690850008780	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
690850008781	HlyD family secretion protein; Region: HlyD_3; pfam13437
690850008782	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
690850008783	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
690850008784	Methyltransferase domain; Region: Methyltransf_23; pfam13489
690850008785	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850008786	S-adenosylmethionine binding site [chemical binding]; other site
690850008787	conserved hypothetical protein; Region: TIGR02231
690850008788	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
690850008789	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
690850008790	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
690850008791	ATP binding site [chemical binding]; other site
690850008792	substrate binding site [chemical binding]; other site
690850008793	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
690850008794	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
690850008795	CPxP  motif; other site
690850008796	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
690850008797	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
690850008798	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
690850008799	DNA binding site [nucleotide binding]
690850008800	AAA domain; Region: AAA_30; pfam13604
690850008801	Family description; Region: UvrD_C_2; pfam13538
690850008802	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
690850008803	substrate binding site [chemical binding]; other site
690850008804	dimer interface [polypeptide binding]; other site
690850008805	ATP binding site [chemical binding]; other site
690850008806	Polycystin cation channel protein; Provisional; Region: PLN03223
690850008807	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850008808	dimerization interface [polypeptide binding]; other site
690850008809	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850008810	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850008811	dimer interface [polypeptide binding]; other site
690850008812	putative CheW interface [polypeptide binding]; other site
690850008813	trigger factor; Provisional; Region: tig; PRK01490
690850008814	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
690850008815	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
690850008816	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
690850008817	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
690850008818	oligomer interface [polypeptide binding]; other site
690850008819	active site residues [active]
690850008820	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
690850008821	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
690850008822	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850008823	Walker A motif; other site
690850008824	ATP binding site [chemical binding]; other site
690850008825	Walker B motif; other site
690850008826	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
690850008827	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
690850008828	Found in ATP-dependent protease La (LON); Region: LON; smart00464
690850008829	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850008830	Walker A motif; other site
690850008831	ATP binding site [chemical binding]; other site
690850008832	Walker B motif; other site
690850008833	arginine finger; other site
690850008834	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
690850008835	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
690850008836	substrate binding site [chemical binding]; other site
690850008837	hypothetical protein; Provisional; Region: PRK02250
690850008838	SEC-C motif; Region: SEC-C; pfam02810
690850008839	ornithine carbamoyltransferase; Provisional; Region: PRK00779
690850008840	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
690850008841	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
690850008842	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850008843	Coenzyme A binding pocket [chemical binding]; other site
690850008844	argininosuccinate synthase; Provisional; Region: PRK13820
690850008845	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
690850008846	ANP binding site [chemical binding]; other site
690850008847	Substrate Binding Site II [chemical binding]; other site
690850008848	Substrate Binding Site I [chemical binding]; other site
690850008849	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
690850008850	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
690850008851	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
690850008852	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
690850008853	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
690850008854	motif II; other site
690850008855	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
690850008856	argininosuccinate lyase; Provisional; Region: PRK00855
690850008857	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
690850008858	active sites [active]
690850008859	tetramer interface [polypeptide binding]; other site
690850008860	30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806
690850008861	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
690850008862	RNA binding site [nucleotide binding]; other site
690850008863	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
690850008864	RNA binding site [nucleotide binding]; other site
690850008865	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
690850008866	RNA binding site [nucleotide binding]; other site
690850008867	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
690850008868	RNA binding site [nucleotide binding]; other site
690850008869	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
690850008870	RNA binding site [nucleotide binding]; other site
690850008871	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
690850008872	elongation factor G; Reviewed; Region: PRK12740
690850008873	G1 box; other site
690850008874	putative GEF interaction site [polypeptide binding]; other site
690850008875	GTP/Mg2+ binding site [chemical binding]; other site
690850008876	Switch I region; other site
690850008877	G2 box; other site
690850008878	G3 box; other site
690850008879	Switch II region; other site
690850008880	G4 box; other site
690850008881	G5 box; other site
690850008882	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
690850008883	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
690850008884	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
690850008885	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
690850008886	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850008887	Coenzyme A binding pocket [chemical binding]; other site
690850008888	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
690850008889	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
690850008890	putative acyl-acceptor binding pocket; other site
690850008891	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
690850008892	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
690850008893	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
690850008894	Protein of unknown function (DUF3897); Region: DUF3897; pfam13036
690850008895	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
690850008896	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
690850008897	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
690850008898	IHF - DNA interface [nucleotide binding]; other site
690850008899	IHF dimer interface [polypeptide binding]; other site
690850008900	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
690850008901	Ligand Binding Site [chemical binding]; other site
690850008902	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
690850008903	homotrimer interaction site [polypeptide binding]; other site
690850008904	putative active site [active]
690850008905	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
690850008906	Archaea-specific editing domain of threonyl-tRNA synthetase; Region: tRNA-Thr_ED; pfam08915
690850008907	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
690850008908	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850008909	Zn2+ binding site [ion binding]; other site
690850008910	Mg2+ binding site [ion binding]; other site
690850008911	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850008912	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850008913	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
690850008914	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850008915	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850008916	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850008917	putative active site [active]
690850008918	heme pocket [chemical binding]; other site
690850008919	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850008920	dimer interface [polypeptide binding]; other site
690850008921	phosphorylation site [posttranslational modification]
690850008922	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850008923	ATP binding site [chemical binding]; other site
690850008924	Mg2+ binding site [ion binding]; other site
690850008925	G-X-G motif; other site
690850008926	Response regulator receiver domain; Region: Response_reg; pfam00072
690850008927	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850008928	active site
690850008929	phosphorylation site [posttranslational modification]
690850008930	intermolecular recognition site; other site
690850008931	dimerization interface [polypeptide binding]; other site
690850008932	Hpt domain; Region: Hpt; pfam01627
690850008933	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
690850008934	active site
690850008935	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
690850008936	active site
690850008937	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
690850008938	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
690850008939	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
690850008940	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
690850008941	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
690850008942	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
690850008943	FMN binding site [chemical binding]; other site
690850008944	substrate binding site [chemical binding]; other site
690850008945	putative catalytic residue [active]
690850008946	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
690850008947	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
690850008948	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
690850008949	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
690850008950	VanZ like family; Region: VanZ; cl01971
690850008951	Uncharacterized conserved protein [Function unknown]; Region: COG4095
690850008952	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
690850008953	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
690850008954	ACS interaction site; other site
690850008955	CODH interaction site; other site
690850008956	Prismane/CO dehydrogenase family; Region: Prismane; pfam03063
690850008957	cubane metal cluster (B-cluster) [ion binding]; other site
690850008958	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
690850008959	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
690850008960	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
690850008961	ligand binding site [chemical binding]; other site
690850008962	flexible hinge region; other site
690850008963	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
690850008964	putative switch regulator; other site
690850008965	non-specific DNA interactions [nucleotide binding]; other site
690850008966	DNA binding site [nucleotide binding]
690850008967	sequence specific DNA binding site [nucleotide binding]; other site
690850008968	putative cAMP binding site [chemical binding]; other site
690850008969	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
690850008970	rRNA binding site [nucleotide binding]; other site
690850008971	predicted 30S ribosome binding site; other site
690850008972	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
690850008973	putative CheA interaction surface; other site
690850008974	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
690850008975	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850008976	metal binding site [ion binding]; metal-binding site
690850008977	active site
690850008978	I-site; other site
690850008979	Repair protein; Region: Repair_PSII; cl01535
690850008980	Repair protein; Region: Repair_PSII; pfam04536
690850008981	LemA family; Region: LemA; cl00742
690850008982	Global regulator protein family; Region: CsrA; pfam02599
690850008983	flagellar assembly protein FliW; Provisional; Region: PRK13285
690850008984	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
690850008985	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
690850008986	ATP-NAD kinase; Region: NAD_kinase; pfam01513
690850008987	MltA specific insert domain; Region: MltA; smart00925
690850008988	3D domain; Region: 3D; pfam06725
690850008989	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
690850008990	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
690850008991	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
690850008992	GatB domain; Region: GatB_Yqey; smart00845
690850008993	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
690850008994	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
690850008995	GTP-binding protein Der; Reviewed; Region: PRK00093
690850008996	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
690850008997	G1 box; other site
690850008998	GTP/Mg2+ binding site [chemical binding]; other site
690850008999	Switch I region; other site
690850009000	G2 box; other site
690850009001	Switch II region; other site
690850009002	G3 box; other site
690850009003	G4 box; other site
690850009004	G5 box; other site
690850009005	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
690850009006	G1 box; other site
690850009007	GTP/Mg2+ binding site [chemical binding]; other site
690850009008	Switch I region; other site
690850009009	G2 box; other site
690850009010	G3 box; other site
690850009011	Switch II region; other site
690850009012	G4 box; other site
690850009013	G5 box; other site
690850009014	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
690850009015	Creatinine amidohydrolase; Region: Creatininase; pfam02633
690850009016	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
690850009017	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
690850009018	Transcriptional regulators [Transcription]; Region: MarR; COG1846
690850009019	MarR family; Region: MarR_2; cl17246
690850009020	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
690850009021	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
690850009022	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
690850009023	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
690850009024	putative active site; other site
690850009025	catalytic residue [active]
690850009026	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
690850009027	NlpC/P60 family; Region: NLPC_P60; pfam00877
690850009028	Flagellin N-methylase; Region: FliB; cl00497
690850009029	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
690850009030	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
690850009031	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
690850009032	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
690850009033	diiron binding motif [ion binding]; other site
690850009034	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
690850009035	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
690850009036	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
690850009037	FAD binding pocket [chemical binding]; other site
690850009038	FAD binding motif [chemical binding]; other site
690850009039	phosphate binding motif [ion binding]; other site
690850009040	beta-alpha-beta structure motif; other site
690850009041	NAD binding pocket [chemical binding]; other site
690850009042	Iron coordination center [ion binding]; other site
690850009043	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
690850009044	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
690850009045	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
690850009046	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
690850009047	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850009048	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
690850009049	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
690850009050	4Fe-4S binding domain; Region: Fer4; pfam00037
690850009051	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
690850009052	Cysteine-rich domain; Region: CCG; pfam02754
690850009053	Cysteine-rich domain; Region: CCG; pfam02754
690850009054	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850009055	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
690850009056	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
690850009057	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
690850009058	dimer interface [polypeptide binding]; other site
690850009059	active site
690850009060	metal binding site [ion binding]; metal-binding site
690850009061	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850009062	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850009063	active site
690850009064	phosphorylation site [posttranslational modification]
690850009065	intermolecular recognition site; other site
690850009066	dimerization interface [polypeptide binding]; other site
690850009067	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850009068	Walker A motif; other site
690850009069	ATP binding site [chemical binding]; other site
690850009070	Walker B motif; other site
690850009071	arginine finger; other site
690850009072	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850009073	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
690850009074	PAS domain; Region: PAS_9; pfam13426
690850009075	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850009076	dimer interface [polypeptide binding]; other site
690850009077	phosphorylation site [posttranslational modification]
690850009078	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850009079	ATP binding site [chemical binding]; other site
690850009080	Mg2+ binding site [ion binding]; other site
690850009081	G-X-G motif; other site
690850009082	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188
690850009083	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
690850009084	putative active site [active]
690850009085	metal binding site [ion binding]; metal-binding site
690850009086	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
690850009087	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850009088	Walker A motif; other site
690850009089	ATP binding site [chemical binding]; other site
690850009090	Walker B motif; other site
690850009091	arginine finger; other site
690850009092	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
690850009093	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
690850009094	hypothetical protein; Validated; Region: PRK00153
690850009095	recombination protein RecR; Reviewed; Region: recR; PRK00076
690850009096	RecR protein; Region: RecR; pfam02132
690850009097	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
690850009098	putative active site [active]
690850009099	putative metal-binding site [ion binding]; other site
690850009100	tetramer interface [polypeptide binding]; other site
690850009101	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
690850009102	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850009103	active site
690850009104	phosphorylation site [posttranslational modification]
690850009105	intermolecular recognition site; other site
690850009106	dimerization interface [polypeptide binding]; other site
690850009107	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
690850009108	DNA binding residues [nucleotide binding]
690850009109	dimerization interface [polypeptide binding]; other site
690850009110	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
690850009111	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
690850009112	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
690850009113	putative active site [active]
690850009114	putative metal binding residues [ion binding]; other site
690850009115	signature motif; other site
690850009116	putative triphosphate binding site [ion binding]; other site
690850009117	dimer interface [polypeptide binding]; other site
690850009118	Uncharacterized conserved protein [Function unknown]; Region: COG2127
690850009119	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
690850009120	Clp amino terminal domain; Region: Clp_N; pfam02861
690850009121	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850009122	Walker A motif; other site
690850009123	ATP binding site [chemical binding]; other site
690850009124	Walker B motif; other site
690850009125	arginine finger; other site
690850009126	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850009127	Walker A motif; other site
690850009128	ATP binding site [chemical binding]; other site
690850009129	Walker B motif; other site
690850009130	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
690850009131	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
690850009132	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
690850009133	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
690850009134	putative active site [active]
690850009135	excinuclease ABC subunit B; Provisional; Region: PRK05298
690850009136	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
690850009137	ATP binding site [chemical binding]; other site
690850009138	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
690850009139	nucleotide binding region [chemical binding]; other site
690850009140	ATP-binding site [chemical binding]; other site
690850009141	Ultra-violet resistance protein B; Region: UvrB; pfam12344
690850009142	UvrB/uvrC motif; Region: UVR; pfam02151
690850009143	Ion channel; Region: Ion_trans_2; pfam07885
690850009144	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
690850009145	TrkA-N domain; Region: TrkA_N; pfam02254
690850009146	TrkA-C domain; Region: TrkA_C; pfam02080
690850009147	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
690850009148	Ligase N family; Region: LIGANc; smart00532
690850009149	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
690850009150	nucleotide binding pocket [chemical binding]; other site
690850009151	K-X-D-G motif; other site
690850009152	catalytic site [active]
690850009153	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
690850009154	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
690850009155	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
690850009156	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
690850009157	Dimer interface [polypeptide binding]; other site
690850009158	BRCT sequence motif; other site
690850009159	dihydrodipicolinate reductase; Provisional; Region: PRK00048
690850009160	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
690850009161	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
690850009162	dihydrodipicolinate reductase; Provisional; Region: PRK00048
690850009163	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
690850009164	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
690850009165	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
690850009166	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
690850009167	acyl-activating enzyme (AAE) consensus motif; other site
690850009168	putative AMP binding site [chemical binding]; other site
690850009169	putative active site [active]
690850009170	putative CoA binding site [chemical binding]; other site
690850009171	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
690850009172	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
690850009173	active site
690850009174	catalytic site [active]
690850009175	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
690850009176	HSP70 interaction site [polypeptide binding]; other site
690850009177	Flagellin N-methylase; Region: FliB; pfam03692
690850009178	CoA binding domain; Region: CoA_binding_2; pfam13380
690850009179	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
690850009180	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
690850009181	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
690850009182	active site
690850009183	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
690850009184	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
690850009185	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
690850009186	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
690850009187	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
690850009188	L-aspartate oxidase; Provisional; Region: PRK06175
690850009189	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
690850009190	quinolinate synthetase; Provisional; Region: PRK09375
690850009191	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
690850009192	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
690850009193	dimerization interface [polypeptide binding]; other site
690850009194	active site
690850009195	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
690850009196	MgtE intracellular N domain; Region: MgtE_N; pfam03448
690850009197	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
690850009198	Divalent cation transporter; Region: MgtE; pfam01769
690850009199	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
690850009200	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850009201	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
690850009202	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
690850009203	Tetratricopeptide repeat; Region: TPR_6; pfam13174
690850009204	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
690850009205	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
690850009206	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
690850009207	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
690850009208	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
690850009209	active site
690850009210	HIGH motif; other site
690850009211	nucleotide binding site [chemical binding]; other site
690850009212	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
690850009213	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
690850009214	active site
690850009215	KMSKS motif; other site
690850009216	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
690850009217	tRNA binding surface [nucleotide binding]; other site
690850009218	anticodon binding site; other site
690850009219	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
690850009220	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
690850009221	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850009222	ATP binding site [chemical binding]; other site
690850009223	Mg2+ binding site [ion binding]; other site
690850009224	G-X-G motif; other site
690850009225	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
690850009226	ATP binding site [chemical binding]; other site
690850009227	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
690850009228	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
690850009229	Organic solvent tolerance protein; Region: OstA_C; pfam04453
690850009230	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
690850009231	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
690850009232	active site
690850009233	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
690850009234	dimer interface [polypeptide binding]; other site
690850009235	substrate binding site [chemical binding]; other site
690850009236	catalytic residues [active]
690850009237	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
690850009238	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
690850009239	cobalt transport protein CbiM; Validated; Region: PRK06265
690850009240	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
690850009241	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850009242	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
690850009243	putative ADP-binding pocket [chemical binding]; other site
690850009244	HD domain; Region: HD_3; cl17350
690850009245	HD domain; Region: HD_3; pfam13023
690850009246	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
690850009247	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850009248	dimer interface [polypeptide binding]; other site
690850009249	conserved gate region; other site
690850009250	putative PBP binding loops; other site
690850009251	ABC-ATPase subunit interface; other site
690850009252	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
690850009253	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
690850009254	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850009255	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
690850009256	Walker A/P-loop; other site
690850009257	ATP binding site [chemical binding]; other site
690850009258	Q-loop/lid; other site
690850009259	ABC transporter signature motif; other site
690850009260	Walker B; other site
690850009261	D-loop; other site
690850009262	H-loop/switch region; other site
690850009263	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
690850009264	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
690850009265	AlkA N-terminal domain; Region: AlkA_N; cl05528
690850009266	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
690850009267	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
690850009268	minor groove reading motif; other site
690850009269	helix-hairpin-helix signature motif; other site
690850009270	substrate binding pocket [chemical binding]; other site
690850009271	active site
690850009272	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
690850009273	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
690850009274	PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301
690850009275	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
690850009276	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
690850009277	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
690850009278	DNA binding site [nucleotide binding]
690850009279	active site
690850009280	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
690850009281	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850009282	Coenzyme A binding pocket [chemical binding]; other site
690850009283	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
690850009284	short chain dehydrogenase; Provisional; Region: PRK06701
690850009285	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
690850009286	NAD binding site [chemical binding]; other site
690850009287	metal binding site [ion binding]; metal-binding site
690850009288	active site
690850009289	phosphoenolpyruvate synthase; Validated; Region: PRK06464
690850009290	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
690850009291	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
690850009292	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
690850009293	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
690850009294	Protein of unknown function, DUF482; Region: DUF482; pfam04339
690850009295	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
690850009296	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
690850009297	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
690850009298	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850009299	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
690850009300	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
690850009301	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
690850009302	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
690850009303	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
690850009304	tRNA; other site
690850009305	putative tRNA binding site [nucleotide binding]; other site
690850009306	putative NADP binding site [chemical binding]; other site
690850009307	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
690850009308	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
690850009309	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
690850009310	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
690850009311	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
690850009312	Active Sites [active]
690850009313	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
690850009314	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
690850009315	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
690850009316	prolyl-tRNA synthetase; Provisional; Region: PRK09194
690850009317	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
690850009318	dimer interface [polypeptide binding]; other site
690850009319	motif 1; other site
690850009320	active site
690850009321	motif 2; other site
690850009322	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
690850009323	putative deacylase active site [active]
690850009324	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
690850009325	active site
690850009326	motif 3; other site
690850009327	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
690850009328	anticodon binding site; other site
690850009329	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
690850009330	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
690850009331	generic binding surface II; other site
690850009332	generic binding surface I; other site
690850009333	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
690850009334	Peptidase family M23; Region: Peptidase_M23; pfam01551
690850009335	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
690850009336	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
690850009337	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
690850009338	substrate binding pocket [chemical binding]; other site
690850009339	chain length determination region; other site
690850009340	substrate-Mg2+ binding site; other site
690850009341	catalytic residues [active]
690850009342	aspartate-rich region 1; other site
690850009343	active site lid residues [active]
690850009344	aspartate-rich region 2; other site
690850009345	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
690850009346	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
690850009347	TPP-binding site; other site
690850009348	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
690850009349	PYR/PP interface [polypeptide binding]; other site
690850009350	dimer interface [polypeptide binding]; other site
690850009351	TPP binding site [chemical binding]; other site
690850009352	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
690850009353	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
690850009354	GAF domain; Region: GAF_3; pfam13492
690850009355	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850009356	Zn2+ binding site [ion binding]; other site
690850009357	Mg2+ binding site [ion binding]; other site
690850009358	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537
690850009359	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
690850009360	active site
690850009361	nucleotide binding site [chemical binding]; other site
690850009362	HIGH motif; other site
690850009363	KMSKS motif; other site
690850009364	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
690850009365	ligand-binding site [chemical binding]; other site
690850009366	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
690850009367	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
690850009368	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
690850009369	catalytic site [active]
690850009370	active site
690850009371	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
690850009372	glycogen branching enzyme; Provisional; Region: PRK12313
690850009373	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
690850009374	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
690850009375	active site
690850009376	catalytic site [active]
690850009377	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
690850009378	trehalose synthase; Region: treS_nterm; TIGR02456
690850009379	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
690850009380	active site
690850009381	catalytic site [active]
690850009382	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
690850009383	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
690850009384	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
690850009385	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
690850009386	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
690850009387	active site
690850009388	homodimer interface [polypeptide binding]; other site
690850009389	catalytic site [active]
690850009390	acceptor binding site [chemical binding]; other site
690850009391	Pirin-related protein [General function prediction only]; Region: COG1741
690850009392	Pirin; Region: Pirin; pfam02678
690850009393	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
690850009394	catalytic core [active]
690850009395	Protein of unknown function (DUF342); Region: DUF342; pfam03961
690850009396	Protein of unknown function (DUF342); Region: DUF342; pfam03961
690850009397	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
690850009398	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
690850009399	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
690850009400	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
690850009401	ligand binding site [chemical binding]; other site
690850009402	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
690850009403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850009404	ABC-ATPase subunit interface; other site
690850009405	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
690850009406	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
690850009407	Walker A/P-loop; other site
690850009408	ATP binding site [chemical binding]; other site
690850009409	Q-loop/lid; other site
690850009410	ABC transporter signature motif; other site
690850009411	Walker B; other site
690850009412	D-loop; other site
690850009413	H-loop/switch region; other site
690850009414	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
690850009415	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850009416	dimer interface [polypeptide binding]; other site
690850009417	conserved gate region; other site
690850009418	putative PBP binding loops; other site
690850009419	ABC-ATPase subunit interface; other site
690850009420	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
690850009421	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
690850009422	CheD chemotactic sensory transduction; Region: CheD; cl00810
690850009423	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
690850009424	active site
690850009425	DNA polymerase IV; Validated; Region: PRK02406
690850009426	DNA binding site [nucleotide binding]
690850009427	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
690850009428	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
690850009429	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
690850009430	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
690850009431	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
690850009432	twin arginine translocase protein A; Provisional; Region: tatA; PRK14859
690850009433	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
690850009434	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
690850009435	active site
690850009436	motif I; other site
690850009437	motif II; other site
690850009438	YGGT family; Region: YGGT; pfam02325
690850009439	DivIVA protein; Region: DivIVA; pfam05103
690850009440	DivIVA domain; Region: DivI1A_domain; TIGR03544
690850009441	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
690850009442	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
690850009443	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
690850009444	PYR/PP interface [polypeptide binding]; other site
690850009445	dimer interface [polypeptide binding]; other site
690850009446	TPP binding site [chemical binding]; other site
690850009447	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
690850009448	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
690850009449	TPP-binding site [chemical binding]; other site
690850009450	dimer interface [polypeptide binding]; other site
690850009451	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
690850009452	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
690850009453	putative valine binding site [chemical binding]; other site
690850009454	dimer interface [polypeptide binding]; other site
690850009455	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
690850009456	ketol-acid reductoisomerase; Provisional; Region: PRK05479
690850009457	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
690850009458	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
690850009459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
690850009460	Major Facilitator Superfamily; Region: MFS_1; pfam07690
690850009461	putative substrate translocation pore; other site
690850009462	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
690850009463	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
690850009464	Predicted permeases [General function prediction only]; Region: COG0795
690850009465	Predicted permeases [General function prediction only]; Region: COG0795
690850009466	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
690850009467	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
690850009468	G1 box; other site
690850009469	GTP/Mg2+ binding site [chemical binding]; other site
690850009470	Switch I region; other site
690850009471	G2 box; other site
690850009472	G3 box; other site
690850009473	Switch II region; other site
690850009474	G4 box; other site
690850009475	G5 box; other site
690850009476	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
690850009477	Dehydroquinase class II; Region: DHquinase_II; pfam01220
690850009478	trimer interface [polypeptide binding]; other site
690850009479	active site
690850009480	dimer interface [polypeptide binding]; other site
690850009481	elongation factor P; Validated; Region: PRK00529
690850009482	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
690850009483	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
690850009484	RNA binding site [nucleotide binding]; other site
690850009485	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
690850009486	RNA binding site [nucleotide binding]; other site
690850009487	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
690850009488	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
690850009489	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
690850009490	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
690850009491	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
690850009492	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
690850009493	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
690850009494	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
690850009495	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
690850009496	RNA binding surface [nucleotide binding]; other site
690850009497	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
690850009498	active site
690850009499	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
690850009500	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
690850009501	CPxP  motif; other site
690850009502	DsrE/DsrF-like family; Region: DrsE; pfam02635
690850009503	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
690850009504	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
690850009505	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
690850009506	Walker A/P-loop; other site
690850009507	ATP binding site [chemical binding]; other site
690850009508	Q-loop/lid; other site
690850009509	ABC transporter signature motif; other site
690850009510	Walker B; other site
690850009511	D-loop; other site
690850009512	H-loop/switch region; other site
690850009513	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
690850009514	putative acyl-acceptor binding pocket; other site
690850009515	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
690850009516	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
690850009517	putative acyl-acceptor binding pocket; other site
690850009518	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
690850009519	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
690850009520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
690850009521	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
690850009522	Flavoprotein; Region: Flavoprotein; pfam02441
690850009523	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
690850009524	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
690850009525	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850009526	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
690850009527	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
690850009528	catalytic center binding site [active]
690850009529	ATP binding site [chemical binding]; other site
690850009530	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
690850009531	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
690850009532	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850009533	homodimer interface [polypeptide binding]; other site
690850009534	catalytic residue [active]
690850009535	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
690850009536	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
690850009537	active site
690850009538	DNA binding site [nucleotide binding]
690850009539	Int/Topo IB signature motif; other site
690850009540	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
690850009541	DHH family; Region: DHH; pfam01368
690850009542	FOG: CBS domain [General function prediction only]; Region: COG0517
690850009543	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
690850009544	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
690850009545	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
690850009546	active site
690850009547	NTP binding site [chemical binding]; other site
690850009548	metal binding triad [ion binding]; metal-binding site
690850009549	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
690850009550	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
690850009551	nucleotide binding site/active site [active]
690850009552	HIT family signature motif; other site
690850009553	catalytic residue [active]
690850009554	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
690850009555	tetratricopeptide repeat protein; Provisional; Region: PRK11788
690850009556	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
690850009557	binding surface
690850009558	TPR motif; other site
690850009559	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
690850009560	MutS domain I; Region: MutS_I; pfam01624
690850009561	MutS domain II; Region: MutS_II; pfam05188
690850009562	MutS domain III; Region: MutS_III; pfam05192
690850009563	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
690850009564	Walker A/P-loop; other site
690850009565	ATP binding site [chemical binding]; other site
690850009566	Q-loop/lid; other site
690850009567	ABC transporter signature motif; other site
690850009568	Walker B; other site
690850009569	D-loop; other site
690850009570	H-loop/switch region; other site
690850009571	diaminopimelate decarboxylase; Region: lysA; TIGR01048
690850009572	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
690850009573	active site
690850009574	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
690850009575	substrate binding site [chemical binding]; other site
690850009576	catalytic residues [active]
690850009577	dimer interface [polypeptide binding]; other site
690850009578	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
690850009579	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850009580	active site
690850009581	phosphorylation site [posttranslational modification]
690850009582	intermolecular recognition site; other site
690850009583	dimerization interface [polypeptide binding]; other site
690850009584	CheB methylesterase; Region: CheB_methylest; pfam01339
690850009585	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
690850009586	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
690850009587	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
690850009588	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
690850009589	putative binding surface; other site
690850009590	active site
690850009591	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
690850009592	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850009593	ATP binding site [chemical binding]; other site
690850009594	Mg2+ binding site [ion binding]; other site
690850009595	G-X-G motif; other site
690850009596	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
690850009597	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850009598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850009599	active site
690850009600	phosphorylation site [posttranslational modification]
690850009601	intermolecular recognition site; other site
690850009602	dimerization interface [polypeptide binding]; other site
690850009603	STAS domain; Region: STAS_2; pfam13466
690850009604	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
690850009605	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850009606	dimer interface [polypeptide binding]; other site
690850009607	putative CheW interface [polypeptide binding]; other site
690850009608	Methyltransferase domain; Region: Methyltransf_31; pfam13847
690850009609	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850009610	S-adenosylmethionine binding site [chemical binding]; other site
690850009611	Methyltransferase domain; Region: Methyltransf_23; pfam13489
690850009612	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850009613	S-adenosylmethionine binding site [chemical binding]; other site
690850009614	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
690850009615	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850009616	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
690850009617	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
690850009618	putative ADP-binding pocket [chemical binding]; other site
690850009619	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850009620	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
690850009621	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
690850009622	catalytic core [active]
690850009623	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
690850009624	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
690850009625	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928
690850009626	NodB motif; other site
690850009627	putative active site [active]
690850009628	putative catalytic site [active]
690850009629	putative Zn binding site [ion binding]; other site
690850009630	FtsX-like permease family; Region: FtsX; pfam02687
690850009631	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
690850009632	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
690850009633	Walker A/P-loop; other site
690850009634	ATP binding site [chemical binding]; other site
690850009635	Q-loop/lid; other site
690850009636	ABC transporter signature motif; other site
690850009637	Walker B; other site
690850009638	D-loop; other site
690850009639	H-loop/switch region; other site
690850009640	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
690850009641	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538
690850009642	PA/protease or protease-like domain interface [polypeptide binding]; other site
690850009643	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
690850009644	metal binding site [ion binding]; metal-binding site
690850009645	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
690850009646	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
690850009647	FtsX-like permease family; Region: FtsX; pfam02687
690850009648	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
690850009649	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
690850009650	HI0933-like protein; Region: HI0933_like; pfam03486
690850009651	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
690850009652	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
690850009653	active site
690850009654	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
690850009655	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
690850009656	active site
690850009657	FMN binding site [chemical binding]; other site
690850009658	substrate binding site [chemical binding]; other site
690850009659	3Fe-4S cluster binding site [ion binding]; other site
690850009660	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
690850009661	domain_subunit interface; other site
690850009662	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
690850009663	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
690850009664	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
690850009665	Protein export membrane protein; Region: SecD_SecF; pfam02355
690850009666	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
690850009667	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
690850009668	Preprotein translocase subunit; Region: YajC; pfam02699
690850009669	Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981
690850009670	putative subunit interface; other site
690850009671	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
690850009672	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
690850009673	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
690850009674	putative active site [active]
690850009675	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
690850009676	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
690850009677	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
690850009678	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
690850009679	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
690850009680	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
690850009681	active site
690850009682	FMN binding site [chemical binding]; other site
690850009683	substrate binding site [chemical binding]; other site
690850009684	3Fe-4S cluster binding site [ion binding]; other site
690850009685	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
690850009686	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
690850009687	putative dimer interface [polypeptide binding]; other site
690850009688	putative anticodon binding site; other site
690850009689	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
690850009690	homodimer interface [polypeptide binding]; other site
690850009691	motif 1; other site
690850009692	motif 2; other site
690850009693	active site
690850009694	motif 3; other site
690850009695	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
690850009696	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
690850009697	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
690850009698	putative active site [active]
690850009699	putative substrate binding site [chemical binding]; other site
690850009700	putative cosubstrate binding site; other site
690850009701	catalytic site [active]
690850009702	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
690850009703	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
690850009704	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
690850009705	P loop; other site
690850009706	GTP binding site [chemical binding]; other site
690850009707	triosephosphate isomerase; Provisional; Region: PRK14565
690850009708	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
690850009709	substrate binding site [chemical binding]; other site
690850009710	dimer interface [polypeptide binding]; other site
690850009711	catalytic triad [active]
690850009712	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
690850009713	Phosphoglycerate kinase; Region: PGK; pfam00162
690850009714	substrate binding site [chemical binding]; other site
690850009715	hinge regions; other site
690850009716	ADP binding site [chemical binding]; other site
690850009717	catalytic site [active]
690850009718	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
690850009719	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850009720	Coenzyme A binding pocket [chemical binding]; other site
690850009721	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
690850009722	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
690850009723	nudix motif; other site
690850009724	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
690850009725	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
690850009726	active site
690850009727	dimerization interface [polypeptide binding]; other site
690850009728	rod shape-determining protein MreB; Provisional; Region: PRK13930
690850009729	MreB and similar proteins; Region: MreB_like; cd10225
690850009730	nucleotide binding site [chemical binding]; other site
690850009731	Mg binding site [ion binding]; other site
690850009732	putative protofilament interaction site [polypeptide binding]; other site
690850009733	RodZ interaction site [polypeptide binding]; other site
690850009734	GAF domain; Region: GAF; pfam01590
690850009735	GAF domain; Region: GAF_2; pfam13185
690850009736	GAF domain; Region: GAF_3; pfam13492
690850009737	GAF domain; Region: GAF_2; pfam13185
690850009738	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
690850009739	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
690850009740	RNA methyltransferase, RsmE family; Region: TIGR00046
690850009741	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
690850009742	recombination factor protein RarA; Reviewed; Region: PRK13342
690850009743	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
690850009744	Walker B motif; other site
690850009745	arginine finger; other site
690850009746	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
690850009747	TPR repeat; Region: TPR_11; pfam13414
690850009748	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850009749	TPR repeat; Region: TPR_11; pfam13414
690850009750	binding surface
690850009751	TPR motif; other site
690850009752	Predicted acyl esterases [General function prediction only]; Region: COG2936
690850009753	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
690850009754	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
690850009755	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
690850009756	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
690850009757	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
690850009758	active site
690850009759	Zn binding site [ion binding]; other site
690850009760	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
690850009761	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
690850009762	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
690850009763	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
690850009764	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
690850009765	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
690850009766	DNA binding residues [nucleotide binding]
690850009767	DNA primase; Validated; Region: dnaG; PRK05667
690850009768	CHC2 zinc finger; Region: zf-CHC2; cl17510
690850009769	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
690850009770	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
690850009771	active site
690850009772	metal binding site [ion binding]; metal-binding site
690850009773	interdomain interaction site; other site
690850009774	MutS2 family protein; Region: mutS2; TIGR01069
690850009775	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850009776	Walker A/P-loop; other site
690850009777	ATP binding site [chemical binding]; other site
690850009778	Q-loop/lid; other site
690850009779	ABC transporter signature motif; other site
690850009780	Walker B; other site
690850009781	D-loop; other site
690850009782	H-loop/switch region; other site
690850009783	Smr domain; Region: Smr; pfam01713
690850009784	Yqey-like protein; Region: YqeY; pfam09424
690850009785	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
690850009786	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
690850009787	IHF dimer interface [polypeptide binding]; other site
690850009788	IHF - DNA interface [nucleotide binding]; other site
690850009789	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
690850009790	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850009791	S-adenosylmethionine binding site [chemical binding]; other site
690850009792	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
690850009793	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
690850009794	active site
690850009795	homotetramer interface [polypeptide binding]; other site
690850009796	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
690850009797	elongation factor G; Reviewed; Region: PRK00007
690850009798	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
690850009799	G1 box; other site
690850009800	putative GEF interaction site [polypeptide binding]; other site
690850009801	GTP/Mg2+ binding site [chemical binding]; other site
690850009802	Switch I region; other site
690850009803	G2 box; other site
690850009804	G3 box; other site
690850009805	Switch II region; other site
690850009806	G4 box; other site
690850009807	G5 box; other site
690850009808	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
690850009809	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680
690850009810	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
690850009811	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
690850009812	Tetratricopeptide repeat; Region: TPR_18; pfam13512
690850009813	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850009814	binding surface
690850009815	TPR motif; other site
690850009816	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
690850009817	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
690850009818	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
690850009819	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
690850009820	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
690850009821	catalytic residues [active]
690850009822	UGMP family protein; Validated; Region: PRK09604
690850009823	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
690850009824	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
690850009825	AMP binding site [chemical binding]; other site
690850009826	metal binding site [ion binding]; metal-binding site
690850009827	active site
690850009828	Septum formation initiator; Region: DivIC; pfam04977
690850009829	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
690850009830	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
690850009831	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
690850009832	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
690850009833	Walker A motif; other site
690850009834	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
690850009835	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850009836	S-adenosylmethionine binding site [chemical binding]; other site
690850009837	FOG: CBS domain [General function prediction only]; Region: COG0517
690850009838	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
690850009839	HupF/HypC family; Region: HupF_HypC; pfam01455
690850009840	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
690850009841	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
690850009842	putative substrate-binding site; other site
690850009843	nickel binding site [ion binding]; other site
690850009844	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
690850009845	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
690850009846	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
690850009847	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
690850009848	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
690850009849	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
690850009850	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
690850009851	putative substrate-binding site; other site
690850009852	nickel binding site [ion binding]; other site
690850009853	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
690850009854	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
690850009855	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
690850009856	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
690850009857	Peptidase family M23; Region: Peptidase_M23; pfam01551
690850009858	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
690850009859	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
690850009860	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
690850009861	pyruvate carboxylase; Reviewed; Region: PRK12999
690850009862	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
690850009863	ATP-grasp domain; Region: ATP-grasp_4; cl17255
690850009864	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
690850009865	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
690850009866	active site
690850009867	catalytic residues [active]
690850009868	metal binding site [ion binding]; metal-binding site
690850009869	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
690850009870	carboxyltransferase (CT) interaction site; other site
690850009871	biotinylation site [posttranslational modification]; other site
690850009872	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
690850009873	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
690850009874	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
690850009875	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
690850009876	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
690850009877	metal binding triad [ion binding]; metal-binding site
690850009878	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
690850009879	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503
690850009880	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
690850009881	active site
690850009882	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
690850009883	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
690850009884	active site
690850009885	(T/H)XGH motif; other site
690850009886	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
690850009887	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850009888	S-adenosylmethionine binding site [chemical binding]; other site
690850009889	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
690850009890	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
690850009891	Beta-Casp domain; Region: Beta-Casp; smart01027
690850009892	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
690850009893	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
690850009894	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
690850009895	GIY-YIG motif/motif A; other site
690850009896	active site
690850009897	catalytic site [active]
690850009898	putative DNA binding site [nucleotide binding]; other site
690850009899	metal binding site [ion binding]; metal-binding site
690850009900	UvrB/uvrC motif; Region: UVR; pfam02151
690850009901	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
690850009902	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
690850009903	putative DNA binding site [nucleotide binding]; other site
690850009904	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
690850009905	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
690850009906	active site
690850009907	DNA binding site [nucleotide binding]
690850009908	Int/Topo IB signature motif; other site
690850009909	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850009910	active site
690850009911	phosphorylation site [posttranslational modification]
690850009912	intermolecular recognition site; other site
690850009913	dimerization interface [polypeptide binding]; other site
690850009914	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
690850009915	metal binding site [ion binding]; metal-binding site
690850009916	active site
690850009917	I-site; other site
690850009918	HDOD domain; Region: HDOD; pfam08668
690850009919	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850009920	Zn2+ binding site [ion binding]; other site
690850009921	Mg2+ binding site [ion binding]; other site
690850009922	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
690850009923	DNA protecting protein DprA; Region: dprA; TIGR00732
690850009924	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
690850009925	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850009926	binding surface
690850009927	TPR motif; other site
690850009928	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
690850009929	putative binding surface; other site
690850009930	active site
690850009931	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
690850009932	putative binding surface; other site
690850009933	active site
690850009934	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
690850009935	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
690850009936	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850009937	ATP binding site [chemical binding]; other site
690850009938	Mg2+ binding site [ion binding]; other site
690850009939	G-X-G motif; other site
690850009940	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
690850009941	Response regulator receiver domain; Region: Response_reg; pfam00072
690850009942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850009943	active site
690850009944	phosphorylation site [posttranslational modification]
690850009945	intermolecular recognition site; other site
690850009946	dimerization interface [polypeptide binding]; other site
690850009947	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
690850009948	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
690850009949	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
690850009950	P-loop; other site
690850009951	Magnesium ion binding site [ion binding]; other site
690850009952	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
690850009953	Magnesium ion binding site [ion binding]; other site
690850009954	PilZ domain; Region: PilZ; pfam07238
690850009955	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
690850009956	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
690850009957	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
690850009958	HEAT repeats; Region: HEAT_2; pfam13646
690850009959	HEAT repeats; Region: HEAT_2; pfam13646
690850009960	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
690850009961	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
690850009962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850009963	active site
690850009964	phosphorylation site [posttranslational modification]
690850009965	intermolecular recognition site; other site
690850009966	CheB methylesterase; Region: CheB_methylest; pfam01339
690850009967	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
690850009968	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
690850009969	ATP binding site [chemical binding]; other site
690850009970	Mg++ binding site [ion binding]; other site
690850009971	motif III; other site
690850009972	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
690850009973	nucleotide binding region [chemical binding]; other site
690850009974	ATP-binding site [chemical binding]; other site
690850009975	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
690850009976	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
690850009977	DHHA2 domain; Region: DHHA2; pfam02833
690850009978	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
690850009979	active site
690850009980	phosphorylation site [posttranslational modification]
690850009981	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
690850009982	active pocket/dimerization site; other site
690850009983	active site
690850009984	phosphorylation site [posttranslational modification]
690850009985	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
690850009986	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
690850009987	active site
690850009988	phosphorylation site [posttranslational modification]
690850009989	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
690850009990	30S subunit binding site; other site
690850009991	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
690850009992	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
690850009993	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
690850009994	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
690850009995	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
690850009996	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
690850009997	Walker A/P-loop; other site
690850009998	ATP binding site [chemical binding]; other site
690850009999	Q-loop/lid; other site
690850010000	ABC transporter signature motif; other site
690850010001	Walker B; other site
690850010002	D-loop; other site
690850010003	H-loop/switch region; other site
690850010004	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
690850010005	OstA-like protein; Region: OstA; pfam03968
690850010006	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
690850010007	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
690850010008	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
690850010009	CTP synthetase; Validated; Region: pyrG; PRK05380
690850010010	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
690850010011	Catalytic site [active]
690850010012	active site
690850010013	UTP binding site [chemical binding]; other site
690850010014	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
690850010015	active site
690850010016	putative oxyanion hole; other site
690850010017	catalytic triad [active]
690850010018	CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507
690850010019	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
690850010020	conserved cys residue [active]
690850010021	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
690850010022	nucleoside/Zn binding site; other site
690850010023	dimer interface [polypeptide binding]; other site
690850010024	catalytic motif [active]
690850010025	Abortive infection C-terminus; Region: Abi_C; pfam14355
690850010026	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
690850010027	B12 binding site [chemical binding]; other site
690850010028	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850010029	Radical SAM superfamily; Region: Radical_SAM; pfam04055
690850010030	FeS/SAM binding site; other site
690850010031	AAA domain; Region: AAA_28; pfam13521
690850010032	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850010033	Zn2+ binding site [ion binding]; other site
690850010034	Mg2+ binding site [ion binding]; other site
690850010035	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850010036	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850010037	active site
690850010038	phosphorylation site [posttranslational modification]
690850010039	intermolecular recognition site; other site
690850010040	dimerization interface [polypeptide binding]; other site
690850010041	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850010042	Walker A motif; other site
690850010043	ATP binding site [chemical binding]; other site
690850010044	Walker B motif; other site
690850010045	arginine finger; other site
690850010046	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850010047	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850010048	dimerization interface [polypeptide binding]; other site
690850010049	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850010050	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850010051	putative active site [active]
690850010052	heme pocket [chemical binding]; other site
690850010053	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850010054	dimer interface [polypeptide binding]; other site
690850010055	phosphorylation site [posttranslational modification]
690850010056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850010057	ATP binding site [chemical binding]; other site
690850010058	Mg2+ binding site [ion binding]; other site
690850010059	G-X-G motif; other site
690850010060	Response regulator receiver domain; Region: Response_reg; pfam00072
690850010061	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850010062	active site
690850010063	phosphorylation site [posttranslational modification]
690850010064	intermolecular recognition site; other site
690850010065	dimerization interface [polypeptide binding]; other site
690850010066	Tetratricopeptide repeat; Region: TPR_16; pfam13432
690850010067	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850010068	TPR motif; other site
690850010069	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
690850010070	TrkA-N domain; Region: TrkA_N; pfam02254
690850010071	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
690850010072	TrkA-N domain; Region: TrkA_N; pfam02254
690850010073	TrkA-C domain; Region: TrkA_C; pfam02080
690850010074	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
690850010075	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
690850010076	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
690850010077	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
690850010078	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
690850010079	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
690850010080	RNA binding surface [nucleotide binding]; other site
690850010081	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
690850010082	active site
690850010083	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
690850010084	Predicted membrane protein [Function unknown]; Region: COG1238
690850010085	EamA-like transporter family; Region: EamA; pfam00892
690850010086	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
690850010087	EamA-like transporter family; Region: EamA; pfam00892
690850010088	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
690850010089	Family description; Region: UvrD_C_2; pfam13538
690850010090	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
690850010091	probable DNA repair protein; Region: TIGR03623
690850010092	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
690850010093	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
690850010094	trimer interface [polypeptide binding]; other site
690850010095	putative Zn binding site [ion binding]; other site
690850010096	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
690850010097	histidinol dehydrogenase; Region: hisD; TIGR00069
690850010098	NAD binding site [chemical binding]; other site
690850010099	dimerization interface [polypeptide binding]; other site
690850010100	product binding site; other site
690850010101	substrate binding site [chemical binding]; other site
690850010102	zinc binding site [ion binding]; other site
690850010103	catalytic residues [active]
690850010104	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
690850010105	ATP binding site [chemical binding]; other site
690850010106	active site
690850010107	substrate binding site [chemical binding]; other site
690850010108	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
690850010109	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
690850010110	NAD binding site [chemical binding]; other site
690850010111	homotetramer interface [polypeptide binding]; other site
690850010112	homodimer interface [polypeptide binding]; other site
690850010113	substrate binding site [chemical binding]; other site
690850010114	active site
690850010115	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
690850010116	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
690850010117	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
690850010118	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
690850010119	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
690850010120	replicative DNA helicase; Region: DnaB; TIGR00665
690850010121	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
690850010122	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
690850010123	Walker A motif; other site
690850010124	ATP binding site [chemical binding]; other site
690850010125	Walker B motif; other site
690850010126	DNA binding loops [nucleotide binding]
690850010127	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
690850010128	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
690850010129	acyl-activating enzyme (AAE) consensus motif; other site
690850010130	AMP binding site [chemical binding]; other site
690850010131	active site
690850010132	CoA binding site [chemical binding]; other site
690850010133	Protein of unknown function (DUF456); Region: DUF456; cl01069
690850010134	threonine synthase; Validated; Region: PRK06260
690850010135	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
690850010136	homodimer interface [polypeptide binding]; other site
690850010137	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850010138	catalytic residue [active]
690850010139	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
690850010140	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
690850010141	RNA binding surface [nucleotide binding]; other site
690850010142	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850010143	S-adenosylmethionine binding site [chemical binding]; other site
690850010144	EamA-like transporter family; Region: EamA; pfam00892
690850010145	metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921
690850010146	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
690850010147	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
690850010148	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
690850010149	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
690850010150	active site residue [active]
690850010151	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
690850010152	active site residue [active]
690850010153	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
690850010154	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
690850010155	putative active site; other site
690850010156	catalytic residue [active]
690850010157	zinc transporter ZupT; Provisional; Region: PRK04201
690850010158	ZIP Zinc transporter; Region: Zip; pfam02535
690850010159	CsbD-like; Region: CsbD; cl17424
690850010160	Predicted integral membrane protein [Function unknown]; Region: COG5616
690850010161	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
690850010162	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
690850010163	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
690850010164	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
690850010165	Walker A/P-loop; other site
690850010166	ATP binding site [chemical binding]; other site
690850010167	Q-loop/lid; other site
690850010168	ABC transporter signature motif; other site
690850010169	Walker B; other site
690850010170	D-loop; other site
690850010171	H-loop/switch region; other site
690850010172	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
690850010173	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
690850010174	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
690850010175	RNA binding surface [nucleotide binding]; other site
690850010176	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
690850010177	active site
690850010178	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
690850010179	dephospho-CoA kinase; Region: TIGR00152
690850010180	CoA-binding site [chemical binding]; other site
690850010181	ATP-binding [chemical binding]; other site
690850010182	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
690850010183	active site
690850010184	Permease family; Region: Xan_ur_permease; pfam00860
690850010185	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
690850010186	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
690850010187	metal-binding site [ion binding]
690850010188	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
690850010189	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
690850010190	catalytic residues [active]
690850010191	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
690850010192	putative active site pocket [active]
690850010193	4-fold oligomerization interface [polypeptide binding]; other site
690850010194	metal binding residues [ion binding]; metal-binding site
690850010195	3-fold/trimer interface [polypeptide binding]; other site
690850010196	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
690850010197	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
690850010198	GMP synthase; Reviewed; Region: guaA; PRK00074
690850010199	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
690850010200	AMP/PPi binding site [chemical binding]; other site
690850010201	candidate oxyanion hole; other site
690850010202	catalytic triad [active]
690850010203	potential glutamine specificity residues [chemical binding]; other site
690850010204	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
690850010205	ATP Binding subdomain [chemical binding]; other site
690850010206	Ligand Binding sites [chemical binding]; other site
690850010207	Dimerization subdomain; other site
690850010208	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
690850010209	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
690850010210	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
690850010211	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
690850010212	active site
690850010213	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
690850010214	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
690850010215	Walker A/P-loop; other site
690850010216	ATP binding site [chemical binding]; other site
690850010217	Q-loop/lid; other site
690850010218	ABC transporter signature motif; other site
690850010219	Walker B; other site
690850010220	D-loop; other site
690850010221	H-loop/switch region; other site
690850010222	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
690850010223	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
690850010224	Walker A/P-loop; other site
690850010225	ATP binding site [chemical binding]; other site
690850010226	Q-loop/lid; other site
690850010227	ABC transporter signature motif; other site
690850010228	Walker B; other site
690850010229	D-loop; other site
690850010230	H-loop/switch region; other site
690850010231	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
690850010232	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
690850010233	Walker A/P-loop; other site
690850010234	ATP binding site [chemical binding]; other site
690850010235	Q-loop/lid; other site
690850010236	ABC transporter signature motif; other site
690850010237	Walker B; other site
690850010238	D-loop; other site
690850010239	H-loop/switch region; other site
690850010240	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
690850010241	TM-ABC transporter signature motif; other site
690850010242	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
690850010243	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
690850010244	TM-ABC transporter signature motif; other site
690850010245	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
690850010246	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
690850010247	dimerization interface [polypeptide binding]; other site
690850010248	ligand binding site [chemical binding]; other site
690850010249	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850010250	binding surface
690850010251	TPR motif; other site
690850010252	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
690850010253	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
690850010254	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
690850010255	Walker A/P-loop; other site
690850010256	ATP binding site [chemical binding]; other site
690850010257	Q-loop/lid; other site
690850010258	ABC transporter signature motif; other site
690850010259	Walker B; other site
690850010260	D-loop; other site
690850010261	H-loop/switch region; other site
690850010262	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
690850010263	CcmE; Region: CcmE; cl00994
690850010264	Domain of unknown function DUF21; Region: DUF21; pfam01595
690850010265	FOG: CBS domain [General function prediction only]; Region: COG0517
690850010266	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
690850010267	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
690850010268	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
690850010269	putative active site [active]
690850010270	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
690850010271	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
690850010272	putative active site [active]
690850010273	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
690850010274	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
690850010275	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
690850010276	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850010277	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850010278	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850010279	tartrate dehydrogenase; Region: TTC; TIGR02089
690850010280	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
690850010281	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
690850010282	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
690850010283	substrate binding site [chemical binding]; other site
690850010284	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
690850010285	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
690850010286	substrate binding site [chemical binding]; other site
690850010287	ligand binding site [chemical binding]; other site
690850010288	2-isopropylmalate synthase; Validated; Region: PRK00915
690850010289	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
690850010290	active site
690850010291	catalytic residues [active]
690850010292	metal binding site [ion binding]; metal-binding site
690850010293	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
690850010294	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
690850010295	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
690850010296	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
690850010297	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
690850010298	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
690850010299	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
690850010300	heme-binding site [chemical binding]; other site
690850010301	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850010302	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850010303	dimer interface [polypeptide binding]; other site
690850010304	phosphorylation site [posttranslational modification]
690850010305	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850010306	ATP binding site [chemical binding]; other site
690850010307	Mg2+ binding site [ion binding]; other site
690850010308	G-X-G motif; other site
690850010309	Protein of unknown function (DUF523); Region: DUF523; pfam04463
690850010310	Uncharacterized conserved protein [Function unknown]; Region: COG3272
690850010311	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
690850010312	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
690850010313	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
690850010314	active site
690850010315	catalytic tetrad [active]
690850010316	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
690850010317	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
690850010318	active site
690850010319	C-terminal domain interface [polypeptide binding]; other site
690850010320	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
690850010321	active site
690850010322	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
690850010323	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
690850010324	active site
690850010325	catalytic tetrad [active]
690850010326	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850010327	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
690850010328	ferredoxin-type protein NapF; Region: napF; TIGR00402
690850010329	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
690850010330	Uncharacterized conserved protein [Function unknown]; Region: COG2006
690850010331	Domain of unknown function (DUF362); Region: DUF362; pfam04015
690850010332	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
690850010333	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
690850010334	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
690850010335	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
690850010336	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
690850010337	Walker A/P-loop; other site
690850010338	ATP binding site [chemical binding]; other site
690850010339	Q-loop/lid; other site
690850010340	ABC transporter signature motif; other site
690850010341	Walker B; other site
690850010342	D-loop; other site
690850010343	H-loop/switch region; other site
690850010344	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
690850010345	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
690850010346	ATP binding site [chemical binding]; other site
690850010347	putative Mg++ binding site [ion binding]; other site
690850010348	helicase superfamily c-terminal domain; Region: HELICc; smart00490
690850010349	ATP-binding site [chemical binding]; other site
690850010350	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
690850010351	active site
690850010352	tetramer interface; other site
690850010353	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
690850010354	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
690850010355	active site
690850010356	substrate binding site [chemical binding]; other site
690850010357	metal binding site [ion binding]; metal-binding site
690850010358	YbbR-like protein; Region: YbbR; pfam07949
690850010359	YbbR-like protein; Region: YbbR; pfam07949
690850010360	Uncharacterized conserved protein [Function unknown]; Region: COG1624
690850010361	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
690850010362	dihydropteroate synthase; Region: DHPS; TIGR01496
690850010363	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
690850010364	substrate binding pocket [chemical binding]; other site
690850010365	dimer interface [polypeptide binding]; other site
690850010366	inhibitor binding site; inhibition site
690850010367	FtsH Extracellular; Region: FtsH_ext; pfam06480
690850010368	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
690850010369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850010370	Walker A motif; other site
690850010371	ATP binding site [chemical binding]; other site
690850010372	Walker B motif; other site
690850010373	arginine finger; other site
690850010374	Peptidase family M41; Region: Peptidase_M41; pfam01434
690850010375	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
690850010376	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
690850010377	heme-binding residues [chemical binding]; other site
690850010378	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
690850010379	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
690850010380	FMN-binding domain; Region: FMN_bind; cl01081
690850010381	electron transport complex RsxE subunit; Provisional; Region: PRK12405
690850010382	electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943
690850010383	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
690850010384	4Fe-4S binding domain; Region: Fer4; pfam00037
690850010385	NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493
690850010386	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
690850010387	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
690850010388	ApbE family; Region: ApbE; pfam02424
690850010389	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
690850010390	NADPH bind site [chemical binding]; other site
690850010391	putative FMN binding site [chemical binding]; other site
690850010392	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
690850010393	putative FMN binding site [chemical binding]; other site
690850010394	NADPH bind site [chemical binding]; other site
690850010395	BioY family; Region: BioY; pfam02632
690850010396	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
690850010397	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
690850010398	Walker A/P-loop; other site
690850010399	ATP binding site [chemical binding]; other site
690850010400	Q-loop/lid; other site
690850010401	ABC transporter signature motif; other site
690850010402	Walker B; other site
690850010403	D-loop; other site
690850010404	H-loop/switch region; other site
690850010405	Cobalt transport protein; Region: CbiQ; cl00463
690850010406	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
690850010407	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
690850010408	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
690850010409	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
690850010410	PAS fold; Region: PAS_4; pfam08448
690850010411	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850010412	putative active site [active]
690850010413	heme pocket [chemical binding]; other site
690850010414	PAS domain S-box; Region: sensory_box; TIGR00229
690850010415	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850010416	putative active site [active]
690850010417	heme pocket [chemical binding]; other site
690850010418	PAS domain S-box; Region: sensory_box; TIGR00229
690850010419	PAS domain; Region: PAS; smart00091
690850010420	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850010421	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850010422	dimer interface [polypeptide binding]; other site
690850010423	phosphorylation site [posttranslational modification]
690850010424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850010425	ATP binding site [chemical binding]; other site
690850010426	Mg2+ binding site [ion binding]; other site
690850010427	G-X-G motif; other site
690850010428	Response regulator receiver domain; Region: Response_reg; pfam00072
690850010429	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850010430	active site
690850010431	phosphorylation site [posttranslational modification]
690850010432	intermolecular recognition site; other site
690850010433	dimerization interface [polypeptide binding]; other site
690850010434	HAMP domain; Region: HAMP; pfam00672
690850010435	PAS domain; Region: PAS; smart00091
690850010436	PAS domain; Region: PAS_9; pfam13426
690850010437	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850010438	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850010439	dimer interface [polypeptide binding]; other site
690850010440	putative CheW interface [polypeptide binding]; other site
690850010441	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
690850010442	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
690850010443	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850010444	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850010445	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850010446	HAMP domain; Region: HAMP; pfam00672
690850010447	dimerization interface [polypeptide binding]; other site
690850010448	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850010449	PAS domain; Region: PAS_9; pfam13426
690850010450	putative active site [active]
690850010451	heme pocket [chemical binding]; other site
690850010452	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850010453	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850010454	dimer interface [polypeptide binding]; other site
690850010455	putative CheW interface [polypeptide binding]; other site
690850010456	phosphoglyceromutase; Provisional; Region: PRK05434
690850010457	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
690850010458	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
690850010459	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
690850010460	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
690850010461	acyl-activating enzyme (AAE) consensus motif; other site
690850010462	AMP binding site [chemical binding]; other site
690850010463	active site
690850010464	CoA binding site [chemical binding]; other site
690850010465	ACT domain-containing protein [General function prediction only]; Region: COG4747
690850010466	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
690850010467	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
690850010468	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
690850010469	hypothetical protein; Reviewed; Region: PRK09588
690850010470	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850010471	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850010472	dimer interface [polypeptide binding]; other site
690850010473	phosphorylation site [posttranslational modification]
690850010474	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850010475	ATP binding site [chemical binding]; other site
690850010476	Mg2+ binding site [ion binding]; other site
690850010477	G-X-G motif; other site
690850010478	Response regulator receiver domain; Region: Response_reg; pfam00072
690850010479	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850010480	active site
690850010481	phosphorylation site [posttranslational modification]
690850010482	intermolecular recognition site; other site
690850010483	dimerization interface [polypeptide binding]; other site
690850010484	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
690850010485	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
690850010486	thiamine phosphate binding site [chemical binding]; other site
690850010487	active site
690850010488	pyrophosphate binding site [ion binding]; other site
690850010489	Domain of unknown function DUF77; Region: DUF77; pfam01910
690850010490	Protein of unknown function (DUF615); Region: DUF615; pfam04751
690850010491	Dodecin; Region: Dodecin; pfam07311
690850010492	Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172
690850010493	non-heme iron binding site [ion binding]; other site
690850010494	tetramer interface [polypeptide binding]; other site
690850010495	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
690850010496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850010497	S-adenosylmethionine binding site [chemical binding]; other site
690850010498	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
690850010499	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
690850010500	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
690850010501	PYR/PP interface [polypeptide binding]; other site
690850010502	dimer interface [polypeptide binding]; other site
690850010503	TPP binding site [chemical binding]; other site
690850010504	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
690850010505	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
690850010506	TPP-binding site [chemical binding]; other site
690850010507	dimer interface [polypeptide binding]; other site
690850010508	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
690850010509	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
690850010510	active site residue [active]
690850010511	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
690850010512	active site residue [active]
690850010513	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
690850010514	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
690850010515	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
690850010516	DNA binding residues [nucleotide binding]
690850010517	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
690850010518	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
690850010519	Response regulator receiver domain; Region: Response_reg; pfam00072
690850010520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850010521	active site
690850010522	phosphorylation site [posttranslational modification]
690850010523	intermolecular recognition site; other site
690850010524	dimerization interface [polypeptide binding]; other site
690850010525	Response regulator receiver domain; Region: Response_reg; pfam00072
690850010526	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850010527	active site
690850010528	phosphorylation site [posttranslational modification]
690850010529	intermolecular recognition site; other site
690850010530	dimerization interface [polypeptide binding]; other site
690850010531	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
690850010532	Response regulator receiver domain; Region: Response_reg; pfam00072
690850010533	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850010534	active site
690850010535	phosphorylation site [posttranslational modification]
690850010536	intermolecular recognition site; other site
690850010537	dimerization interface [polypeptide binding]; other site
690850010538	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
690850010539	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
690850010540	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
690850010541	Protein of unknown function, DUF485; Region: DUF485; pfam04341
690850010542	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
690850010543	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
690850010544	Na binding site [ion binding]; other site
690850010545	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
690850010546	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
690850010547	FOG: CBS domain [General function prediction only]; Region: COG0517
690850010548	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
690850010549	metal binding triad; other site
690850010550	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
690850010551	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
690850010552	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850010553	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850010554	dimer interface [polypeptide binding]; other site
690850010555	phosphorylation site [posttranslational modification]
690850010556	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850010557	ATP binding site [chemical binding]; other site
690850010558	Mg2+ binding site [ion binding]; other site
690850010559	G-X-G motif; other site
690850010560	PAS domain; Region: PAS_9; pfam13426
690850010561	PAS domain S-box; Region: sensory_box; TIGR00229
690850010562	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850010563	putative active site [active]
690850010564	heme pocket [chemical binding]; other site
690850010565	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
690850010566	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850010567	putative active site [active]
690850010568	heme pocket [chemical binding]; other site
690850010569	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850010570	dimer interface [polypeptide binding]; other site
690850010571	phosphorylation site [posttranslational modification]
690850010572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850010573	ATP binding site [chemical binding]; other site
690850010574	Mg2+ binding site [ion binding]; other site
690850010575	G-X-G motif; other site
690850010576	Response regulator receiver domain; Region: Response_reg; pfam00072
690850010577	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850010578	active site
690850010579	phosphorylation site [posttranslational modification]
690850010580	intermolecular recognition site; other site
690850010581	dimerization interface [polypeptide binding]; other site
690850010582	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
690850010583	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850010584	active site
690850010585	phosphorylation site [posttranslational modification]
690850010586	intermolecular recognition site; other site
690850010587	dimerization interface [polypeptide binding]; other site
690850010588	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850010589	Walker A motif; other site
690850010590	ATP binding site [chemical binding]; other site
690850010591	Walker B motif; other site
690850010592	arginine finger; other site
690850010593	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850010594	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850010595	phosphorylation site [posttranslational modification]
690850010596	dimer interface [polypeptide binding]; other site
690850010597	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850010598	ATP binding site [chemical binding]; other site
690850010599	Mg2+ binding site [ion binding]; other site
690850010600	G-X-G motif; other site
690850010601	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
690850010602	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
690850010603	Transcriptional regulator [Transcription]; Region: LysR; COG0583
690850010604	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
690850010605	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
690850010606	dimerization interface [polypeptide binding]; other site
690850010607	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
690850010608	LysE type translocator; Region: LysE; cl00565
690850010609	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
690850010610	Fatty acid desaturase; Region: FA_desaturase; pfam00487
690850010611	putative di-iron ligands [ion binding]; other site
690850010612	Putative pyruvate format-lyase activating enzyme (DUF1786); Region: DUF1786; cl01638
690850010613	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
690850010614	dimer interface [polypeptide binding]; other site
690850010615	putative tRNA-binding site [nucleotide binding]; other site
690850010616	PGAP1-like protein; Region: PGAP1; pfam07819
690850010617	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
690850010618	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
690850010619	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
690850010620	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850010621	dimer interface [polypeptide binding]; other site
690850010622	putative CheW interface [polypeptide binding]; other site
690850010623	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
690850010624	putative CheA interaction surface; other site
690850010625	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
690850010626	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
690850010627	IHF - DNA interface [nucleotide binding]; other site
690850010628	IHF dimer interface [polypeptide binding]; other site
690850010629	Protein of unknown function (DUF493); Region: DUF493; pfam04359
690850010630	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
690850010631	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
690850010632	Walker A/P-loop; other site
690850010633	ATP binding site [chemical binding]; other site
690850010634	Q-loop/lid; other site
690850010635	ABC transporter signature motif; other site
690850010636	Walker B; other site
690850010637	D-loop; other site
690850010638	H-loop/switch region; other site
690850010639	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
690850010640	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
690850010641	substrate binding pocket [chemical binding]; other site
690850010642	membrane-bound complex binding site; other site
690850010643	hinge residues; other site
690850010644	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850010645	dimer interface [polypeptide binding]; other site
690850010646	conserved gate region; other site
690850010647	putative PBP binding loops; other site
690850010648	ABC-ATPase subunit interface; other site
690850010649	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850010650	dimer interface [polypeptide binding]; other site
690850010651	conserved gate region; other site
690850010652	putative PBP binding loops; other site
690850010653	ABC-ATPase subunit interface; other site
690850010654	Asparaginase; Region: Asparaginase; pfam00710
690850010655	active site
690850010656	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
690850010657	EF-hand domain pair; Region: EF_hand_5; pfam13499
690850010658	Ca2+ binding site [ion binding]; other site
690850010659	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
690850010660	Ca2+ binding site [ion binding]; other site
690850010661	EF-hand domain pair; Region: EF_hand_5; pfam13499
690850010662	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
690850010663	Ca2+ binding site [ion binding]; other site
690850010664	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
690850010665	Ca2+ binding site [ion binding]; other site
690850010666	YceG-like family; Region: YceG; pfam02618
690850010667	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
690850010668	dimerization interface [polypeptide binding]; other site
690850010669	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
690850010670	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
690850010671	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
690850010672	CoA-ligase; Region: Ligase_CoA; pfam00549
690850010673	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
690850010674	CoA binding domain; Region: CoA_binding; pfam02629
690850010675	CoA-ligase; Region: Ligase_CoA; pfam00549
690850010676	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
690850010677	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
690850010678	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
690850010679	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
690850010680	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850010681	S-adenosylmethionine binding site [chemical binding]; other site
690850010682	Protein of unknown function (DUF3135); Region: DUF3135; pfam11333
690850010683	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
690850010684	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
690850010685	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
690850010686	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850010687	FeS/SAM binding site; other site
690850010688	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
690850010689	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
690850010690	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
690850010691	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
690850010692	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
690850010693	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
690850010694	Ligand Binding Site [chemical binding]; other site
690850010695	TIGR00269 family protein; Region: TIGR00269
690850010696	Response regulator receiver domain; Region: Response_reg; pfam00072
690850010697	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850010698	active site
690850010699	phosphorylation site [posttranslational modification]
690850010700	intermolecular recognition site; other site
690850010701	dimerization interface [polypeptide binding]; other site
690850010702	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
690850010703	Peptidase family M50; Region: Peptidase_M50; pfam02163
690850010704	active site
690850010705	putative substrate binding region [chemical binding]; other site
690850010706	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
690850010707	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
690850010708	active site
690850010709	HIGH motif; other site
690850010710	dimer interface [polypeptide binding]; other site
690850010711	KMSKS motif; other site
690850010712	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
690850010713	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
690850010714	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
690850010715	catalytic site [active]
690850010716	active site
690850010717	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
690850010718	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
690850010719	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
690850010720	active site
690850010721	catalytic site [active]
690850010722	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
690850010723	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
690850010724	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
690850010725	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
690850010726	active site
690850010727	catalytic site [active]
690850010728	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850010729	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
690850010730	putative active site [active]
690850010731	heme pocket [chemical binding]; other site
690850010732	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850010733	PAS fold; Region: PAS_3; pfam08447
690850010734	putative active site [active]
690850010735	heme pocket [chemical binding]; other site
690850010736	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850010737	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850010738	dimer interface [polypeptide binding]; other site
690850010739	phosphorylation site [posttranslational modification]
690850010740	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850010741	ATP binding site [chemical binding]; other site
690850010742	Mg2+ binding site [ion binding]; other site
690850010743	G-X-G motif; other site
690850010744	Response regulator receiver domain; Region: Response_reg; pfam00072
690850010745	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850010746	active site
690850010747	phosphorylation site [posttranslational modification]
690850010748	intermolecular recognition site; other site
690850010749	dimerization interface [polypeptide binding]; other site
690850010750	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
690850010751	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
690850010752	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
690850010753	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850010754	FeS/SAM binding site; other site
690850010755	cell division protein FtsZ; Validated; Region: PRK09330
690850010756	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
690850010757	nucleotide binding site [chemical binding]; other site
690850010758	SulA interaction site; other site
690850010759	cell division protein FtsA; Region: ftsA; TIGR01174
690850010760	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
690850010761	nucleotide binding site [chemical binding]; other site
690850010762	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
690850010763	Cell division protein FtsA; Region: FtsA; pfam14450
690850010764	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
690850010765	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
690850010766	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
690850010767	FAD binding domain; Region: FAD_binding_4; pfam01565
690850010768	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
690850010769	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
690850010770	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
690850010771	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
690850010772	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
690850010773	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
690850010774	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
690850010775	active site
690850010776	homodimer interface [polypeptide binding]; other site
690850010777	cell division protein FtsW; Region: ftsW; TIGR02614
690850010778	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
690850010779	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
690850010780	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
690850010781	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
690850010782	Mg++ binding site [ion binding]; other site
690850010783	putative catalytic motif [active]
690850010784	putative substrate binding site [chemical binding]; other site
690850010785	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
690850010786	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
690850010787	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
690850010788	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
690850010789	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
690850010790	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
690850010791	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
690850010792	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
690850010793	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
690850010794	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
690850010795	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
690850010796	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
690850010797	MraW methylase family; Region: Methyltransf_5; cl17771
690850010798	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
690850010799	cell division protein MraZ; Reviewed; Region: PRK00326
690850010800	MraZ protein; Region: MraZ; pfam02381
690850010801	MraZ protein; Region: MraZ; pfam02381
690850010802	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850010803	Zn2+ binding site [ion binding]; other site
690850010804	Mg2+ binding site [ion binding]; other site
690850010805	FOG: CBS domain [General function prediction only]; Region: COG0517
690850010806	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
690850010807	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
690850010808	HD domain; Region: HD_3; pfam13023
690850010809	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
690850010810	23S rRNA interface [nucleotide binding]; other site
690850010811	L3 interface [polypeptide binding]; other site
690850010812	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
690850010813	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850010814	Radical SAM superfamily; Region: Radical_SAM; pfam04055
690850010815	FeS/SAM binding site; other site
690850010816	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
690850010817	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
690850010818	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
690850010819	dimerization interface [polypeptide binding]; other site
690850010820	putative ATP binding site [chemical binding]; other site
690850010821	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
690850010822	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850010823	FeS/SAM binding site; other site
690850010824	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
690850010825	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
690850010826	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
690850010827	HsdM N-terminal domain; Region: HsdM_N; pfam12161
690850010828	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
690850010829	Methyltransferase domain; Region: Methyltransf_26; pfam13659
690850010830	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
690850010831	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
690850010832	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
690850010833	FRG domain; Region: FRG; pfam08867
690850010834	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
690850010835	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
690850010836	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
690850010837	ATP binding site [chemical binding]; other site
690850010838	putative Mg++ binding site [ion binding]; other site
690850010839	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
690850010840	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
690850010841	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
690850010842	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
690850010843	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
690850010844	Mrr N-terminal domain; Region: Mrr_N; pfam14338
690850010845	Restriction endonuclease; Region: Mrr_cat; pfam04471
690850010846	Virulence protein [General function prediction only]; Region: COG3943
690850010847	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
690850010848	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
690850010849	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
690850010850	AAA domain; Region: AAA_11; pfam13086
690850010851	Part of AAA domain; Region: AAA_19; pfam13245
690850010852	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
690850010853	AAA domain; Region: AAA_12; pfam13087
690850010854	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
690850010855	putative active site [active]
690850010856	Mrr N-terminal domain; Region: Mrr_N; pfam14338
690850010857	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
690850010858	Restriction endonuclease; Region: Mrr_cat; pfam04471
690850010859	Family of unknown function (DUF490); Region: DUF490; pfam04357
690850010860	Patatin-like phospholipase; Region: Patatin; pfam01734
690850010861	active site
690850010862	nucleophile elbow; other site
690850010863	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
690850010864	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
690850010865	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
690850010866	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
690850010867	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
690850010868	non-specific DNA binding site [nucleotide binding]; other site
690850010869	salt bridge; other site
690850010870	sequence-specific DNA binding site [nucleotide binding]; other site
690850010871	Predicted transcriptional regulator [Transcription]; Region: COG3905
690850010872	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
690850010873	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
690850010874	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
690850010875	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
690850010876	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
690850010877	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
690850010878	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
690850010879	DctM-like transporters; Region: DctM; pfam06808
690850010880	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
690850010881	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
690850010882	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
690850010883	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
690850010884	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
690850010885	putative NADH binding site [chemical binding]; other site
690850010886	putative active site [active]
690850010887	nudix motif; other site
690850010888	putative metal binding site [ion binding]; other site
690850010889	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
690850010890	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850010891	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
690850010892	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
690850010893	metal binding site 2 [ion binding]; metal-binding site
690850010894	putative DNA binding helix; other site
690850010895	metal binding site 1 [ion binding]; metal-binding site
690850010896	dimer interface [polypeptide binding]; other site
690850010897	structural Zn2+ binding site [ion binding]; other site
690850010898	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
690850010899	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
690850010900	dimer interface [polypeptide binding]; other site
690850010901	active site
690850010902	heme binding site [chemical binding]; other site
690850010903	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
690850010904	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
690850010905	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850010906	active site
690850010907	phosphorylation site [posttranslational modification]
690850010908	intermolecular recognition site; other site
690850010909	dimerization interface [polypeptide binding]; other site
690850010910	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850010911	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850010912	dimer interface [polypeptide binding]; other site
690850010913	phosphorylation site [posttranslational modification]
690850010914	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850010915	ATP binding site [chemical binding]; other site
690850010916	Mg2+ binding site [ion binding]; other site
690850010917	G-X-G motif; other site
690850010918	Response regulator receiver domain; Region: Response_reg; pfam00072
690850010919	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850010920	active site
690850010921	phosphorylation site [posttranslational modification]
690850010922	intermolecular recognition site; other site
690850010923	dimerization interface [polypeptide binding]; other site
690850010924	Response regulator receiver domain; Region: Response_reg; pfam00072
690850010925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850010926	active site
690850010927	phosphorylation site [posttranslational modification]
690850010928	intermolecular recognition site; other site
690850010929	dimerization interface [polypeptide binding]; other site
690850010930	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850010931	dimerization interface [polypeptide binding]; other site
690850010932	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850010933	dimer interface [polypeptide binding]; other site
690850010934	phosphorylation site [posttranslational modification]
690850010935	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850010936	ATP binding site [chemical binding]; other site
690850010937	Mg2+ binding site [ion binding]; other site
690850010938	G-X-G motif; other site
690850010939	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
690850010940	NMT1/THI5 like; Region: NMT1; pfam09084
690850010941	substrate binding pocket [chemical binding]; other site
690850010942	membrane-bound complex binding site; other site
690850010943	hinge residues; other site
690850010944	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
690850010945	PemK-like protein; Region: PemK; cl00995
690850010946	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
690850010947	CHAT domain; Region: CHAT; pfam12770
690850010948	Tetratricopeptide repeat; Region: TPR_12; pfam13424
690850010949	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850010950	binding surface
690850010951	TPR motif; other site
690850010952	Tetratricopeptide repeat; Region: TPR_12; pfam13424
690850010953	Tetratricopeptide repeat; Region: TPR_12; pfam13424
690850010954	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850010955	binding surface
690850010956	TPR motif; other site
690850010957	Tetratricopeptide repeat; Region: TPR_12; pfam13424
690850010958	Tetratricopeptide repeat; Region: TPR_12; pfam13424
690850010959	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
690850010960	Family description; Region: VCBS; pfam13517
690850010961	Family description; Region: VCBS; pfam13517
690850010962	Family description; Region: VCBS; pfam13517
690850010963	Family description; Region: VCBS; pfam13517
690850010964	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
690850010965	REJ domain; Region: REJ; pfam02010
690850010966	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
690850010967	Terminase-like family; Region: Terminase_6; pfam03237
690850010968	Protein of unknown function (DUF3154); Region: DUF3154; pfam11351
690850010969	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
690850010970	amidase catalytic site [active]
690850010971	Zn binding residues [ion binding]; other site
690850010972	substrate binding site [chemical binding]; other site
690850010973	Putative phage tail protein; Region: Phage-tail_3; pfam13550
690850010974	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
690850010975	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850010976	dimerization interface [polypeptide binding]; other site
690850010977	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850010978	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850010979	dimer interface [polypeptide binding]; other site
690850010980	putative CheW interface [polypeptide binding]; other site
690850010981	Staphylococcal nuclease homologues; Region: SNc; smart00318
690850010982	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
690850010983	Catalytic site; other site
690850010984	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
690850010985	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
690850010986	non-specific DNA binding site [nucleotide binding]; other site
690850010987	salt bridge; other site
690850010988	sequence-specific DNA binding site [nucleotide binding]; other site
690850010989	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850010990	FeS/SAM binding site; other site
690850010991	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
690850010992	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850010993	FeS/SAM binding site; other site
690850010994	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
690850010995	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
690850010996	Baseplate J-like protein; Region: Baseplate_J; cl01294
690850010997	PAS fold; Region: PAS_4; pfam08448
690850010998	PAS fold; Region: PAS_4; pfam08448
690850010999	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850011000	putative active site [active]
690850011001	heme pocket [chemical binding]; other site
690850011002	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850011003	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850011004	putative active site [active]
690850011005	heme pocket [chemical binding]; other site
690850011006	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850011007	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850011008	putative active site [active]
690850011009	heme pocket [chemical binding]; other site
690850011010	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850011011	putative active site [active]
690850011012	heme pocket [chemical binding]; other site
690850011013	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
690850011014	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850011015	dimer interface [polypeptide binding]; other site
690850011016	phosphorylation site [posttranslational modification]
690850011017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850011018	ATP binding site [chemical binding]; other site
690850011019	Mg2+ binding site [ion binding]; other site
690850011020	G-X-G motif; other site
690850011021	Response regulator receiver domain; Region: Response_reg; pfam00072
690850011022	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850011023	active site
690850011024	phosphorylation site [posttranslational modification]
690850011025	intermolecular recognition site; other site
690850011026	dimerization interface [polypeptide binding]; other site
690850011027	LPP20 lipoprotein; Region: LPP20; pfam02169
690850011028	LPP20 lipoprotein; Region: LPP20; cl15824
690850011029	FOG: WD40 repeat [General function prediction only]; Region: COG2319
690850011030	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
690850011031	structural tetrad; other site
690850011032	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
690850011033	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
690850011034	XkdW protein; Region: XkdW; pfam09636
690850011035	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
690850011036	Baseplate J-like protein; Region: Baseplate_J; cl01294
690850011037	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
690850011038	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
690850011039	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
690850011040	DNA binding residues [nucleotide binding]
690850011041	NMT1-like family; Region: NMT1_2; pfam13379
690850011042	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
690850011043	HPP family; Region: HPP; pfam04982
690850011044	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
690850011045	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
690850011046	molybdopterin cofactor binding site; other site
690850011047	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
690850011048	molybdopterin cofactor binding site; other site
690850011049	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
690850011050	4Fe-4S binding domain; Region: Fer4; cl02805
690850011051	Phage Tail Collar Domain; Region: Collar; pfam07484
690850011052	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
690850011053	Baseplate J-like protein; Region: Baseplate_J; pfam04865
690850011054	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
690850011055	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
690850011056	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
690850011057	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
690850011058	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
690850011059	Phage tail tube protein FII; Region: Phage_tube; cl01390
690850011060	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
690850011061	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
690850011062	Catalytic site [active]
690850011063	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
690850011064	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
690850011065	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
690850011066	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
690850011067	active site
690850011068	catalytic triad [active]
690850011069	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
690850011070	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850011071	Walker A motif; other site
690850011072	ATP binding site [chemical binding]; other site
690850011073	Walker B motif; other site
690850011074	arginine finger; other site
690850011075	Helix-turn-helix domain; Region: HTH_17; pfam12728
690850011076	Predicted transcriptional regulator [Transcription]; Region: COG2932
690850011077	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
690850011078	Catalytic site [active]
690850011079	CHASE3 domain; Region: CHASE3; pfam05227
690850011080	PAS domain S-box; Region: sensory_box; TIGR00229
690850011081	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
690850011082	PAS domain S-box; Region: sensory_box; TIGR00229
690850011083	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850011084	putative active site [active]
690850011085	heme pocket [chemical binding]; other site
690850011086	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
690850011087	dimer interface [polypeptide binding]; other site
690850011088	phosphorylation site [posttranslational modification]
690850011089	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850011090	ATP binding site [chemical binding]; other site
690850011091	Mg2+ binding site [ion binding]; other site
690850011092	G-X-G motif; other site
690850011093	Response regulator receiver domain; Region: Response_reg; pfam00072
690850011094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850011095	active site
690850011096	phosphorylation site [posttranslational modification]
690850011097	intermolecular recognition site; other site
690850011098	dimerization interface [polypeptide binding]; other site
690850011099	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
690850011100	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
690850011101	putative metal binding site [ion binding]; other site
690850011102	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
690850011103	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
690850011104	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
690850011105	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
690850011106	active site residue [active]
690850011107	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
690850011108	active site residue [active]
690850011109	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
690850011110	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
690850011111	ligand binding site [chemical binding]; other site
690850011112	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
690850011113	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850011114	putative active site [active]
690850011115	heme pocket [chemical binding]; other site
690850011116	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
690850011117	Histidine kinase; Region: HisKA_2; pfam07568
690850011118	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850011119	Mg2+ binding site [ion binding]; other site
690850011120	G-X-G motif; other site
690850011121	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
690850011122	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
690850011123	G1 box; other site
690850011124	putative GEF interaction site [polypeptide binding]; other site
690850011125	GTP/Mg2+ binding site [chemical binding]; other site
690850011126	Switch I region; other site
690850011127	G2 box; other site
690850011128	G3 box; other site
690850011129	Switch II region; other site
690850011130	G4 box; other site
690850011131	G5 box; other site
690850011132	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
690850011133	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
690850011134	Major Facilitator Superfamily; Region: MFS_1; pfam07690
690850011135	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
690850011136	putative substrate translocation pore; other site
690850011137	CrcB-like protein; Region: CRCB; cl09114
690850011138	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
690850011139	FOG: CBS domain [General function prediction only]; Region: COG0517
690850011140	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
690850011141	FOG: CBS domain [General function prediction only]; Region: COG0517
690850011142	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
690850011143	enolase; Provisional; Region: eno; PRK00077
690850011144	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
690850011145	dimer interface [polypeptide binding]; other site
690850011146	metal binding site [ion binding]; metal-binding site
690850011147	substrate binding pocket [chemical binding]; other site
690850011148	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
690850011149	non-specific DNA binding site [nucleotide binding]; other site
690850011150	salt bridge; other site
690850011151	sequence-specific DNA binding site [nucleotide binding]; other site
690850011152	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
690850011153	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
690850011154	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
690850011155	substrate binding site [chemical binding]; other site
690850011156	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
690850011157	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
690850011158	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850011159	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850011160	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850011161	Carbon starvation protein CstA; Region: CstA; pfam02554
690850011162	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
690850011163	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
690850011164	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
690850011165	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
690850011166	GAF domain; Region: GAF; cl17456
690850011167	Histidine kinase; Region: His_kinase; pfam06580
690850011168	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
690850011169	ATP binding site [chemical binding]; other site
690850011170	Mg2+ binding site [ion binding]; other site
690850011171	G-X-G motif; other site
690850011172	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
690850011173	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
690850011174	active site
690850011175	phosphorylation site [posttranslational modification]
690850011176	intermolecular recognition site; other site
690850011177	dimerization interface [polypeptide binding]; other site
690850011178	LytTr DNA-binding domain; Region: LytTR; smart00850
690850011179	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
690850011180	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
690850011181	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
690850011182	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850011183	dimerization interface [polypeptide binding]; other site
690850011184	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850011185	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850011186	dimer interface [polypeptide binding]; other site
690850011187	putative CheW interface [polypeptide binding]; other site
690850011188	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
690850011189	putative CheA interaction surface; other site
690850011190	glutamate racemase; Provisional; Region: PRK00865
690850011191	Protein of unknown function DUF89; Region: DUF89; cl15397
690850011192	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
690850011193	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
690850011194	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
690850011195	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
690850011196	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
690850011197	HlyD family secretion protein; Region: HlyD_3; pfam13437
690850011198	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
690850011199	Protein export membrane protein; Region: SecD_SecF; cl14618
690850011200	Cache domain; Region: Cache_1; pfam02743
690850011201	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850011202	dimerization interface [polypeptide binding]; other site
690850011203	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850011204	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850011205	dimer interface [polypeptide binding]; other site
690850011206	putative CheW interface [polypeptide binding]; other site
690850011207	Cache domain; Region: Cache_1; pfam02743
690850011208	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850011209	dimerization interface [polypeptide binding]; other site
690850011210	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850011211	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850011212	dimer interface [polypeptide binding]; other site
690850011213	putative CheW interface [polypeptide binding]; other site
690850011214	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
690850011215	EamA-like transporter family; Region: EamA; pfam00892
690850011216	EamA-like transporter family; Region: EamA; pfam00892
690850011217	Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475
690850011218	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
690850011219	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
690850011220	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
690850011221	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
690850011222	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
690850011223	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
690850011224	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
690850011225	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
690850011226	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
690850011227	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
690850011228	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
690850011229	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668
690850011230	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
690850011231	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
690850011232	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
690850011233	ligand binding site [chemical binding]; other site
690850011234	flexible hinge region; other site
690850011235	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
690850011236	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
690850011237	ATP binding site [chemical binding]; other site
690850011238	Mg++ binding site [ion binding]; other site
690850011239	motif III; other site
690850011240	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
690850011241	nucleotide binding region [chemical binding]; other site
690850011242	ATP-binding site [chemical binding]; other site
690850011243	MASE1; Region: MASE1; pfam05231
690850011244	PAS domain S-box; Region: sensory_box; TIGR00229
690850011245	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
690850011246	putative active site [active]
690850011247	heme pocket [chemical binding]; other site
690850011248	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
690850011249	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
690850011250	hypothetical protein; Provisional; Region: PRK11281
690850011251	Predicted transcriptional regulators [Transcription]; Region: COG1733
690850011252	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
690850011253	putative Zn2+ binding site [ion binding]; other site
690850011254	putative DNA binding site [nucleotide binding]; other site
690850011255	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
690850011256	putative FMN binding site [chemical binding]; other site
690850011257	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
690850011258	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
690850011259	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
690850011260	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
690850011261	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
690850011262	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
690850011263	putative active site [active]
690850011264	Zn binding site [ion binding]; other site
690850011265	MltA specific insert domain; Region: MltA; smart00925
690850011266	3D domain; Region: 3D; pfam06725
690850011267	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
690850011268	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
690850011269	substrate binding pocket [chemical binding]; other site
690850011270	membrane-bound complex binding site; other site
690850011271	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
690850011272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850011273	dimer interface [polypeptide binding]; other site
690850011274	conserved gate region; other site
690850011275	putative PBP binding loops; other site
690850011276	ABC-ATPase subunit interface; other site
690850011277	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
690850011278	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
690850011279	Walker A/P-loop; other site
690850011280	ATP binding site [chemical binding]; other site
690850011281	Q-loop/lid; other site
690850011282	ABC transporter signature motif; other site
690850011283	Walker B; other site
690850011284	D-loop; other site
690850011285	H-loop/switch region; other site
690850011286	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
690850011287	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850011288	dimer interface [polypeptide binding]; other site
690850011289	conserved gate region; other site
690850011290	putative PBP binding loops; other site
690850011291	ABC-ATPase subunit interface; other site
690850011292	FAD binding domain; Region: FAD_binding_4; pfam01565
690850011293	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
690850011294	aspartate aminotransferase; Provisional; Region: PRK05764
690850011295	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
690850011296	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850011297	homodimer interface [polypeptide binding]; other site
690850011298	catalytic residue [active]
690850011299	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
690850011300	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
690850011301	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
690850011302	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
690850011303	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
690850011304	NAD(P) binding site [chemical binding]; other site
690850011305	active site
690850011306	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
690850011307	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
690850011308	dimer interface [polypeptide binding]; other site
690850011309	active site
690850011310	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
690850011311	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
690850011312	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
690850011313	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
690850011314	dimer interface [polypeptide binding]; other site
690850011315	active site
690850011316	Phosphopantetheine attachment site; Region: PP-binding; cl09936
690850011317	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
690850011318	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
690850011319	putative acyl-acceptor binding pocket; other site
690850011320	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
690850011321	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
690850011322	acyl-activating enzyme (AAE) consensus motif; other site
690850011323	AMP binding site [chemical binding]; other site
690850011324	active site
690850011325	CoA binding site [chemical binding]; other site
690850011326	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850011327	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
690850011328	FeS/SAM binding site; other site
690850011329	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
690850011330	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
690850011331	active site 2 [active]
690850011332	active site 1 [active]
690850011333	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
690850011334	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
690850011335	Predicted exporter [General function prediction only]; Region: COG4258
690850011336	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
690850011337	active site 2 [active]
690850011338	active site 1 [active]
690850011339	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
690850011340	active site
690850011341	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
690850011342	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
690850011343	dimer interface [polypeptide binding]; other site
690850011344	active site
690850011345	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
690850011346	B12 binding domain; Region: B12-binding; pfam02310
690850011347	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
690850011348	B12 binding site [chemical binding]; other site
690850011349	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
690850011350	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850011351	Radical SAM superfamily; Region: Radical_SAM; pfam04055
690850011352	FeS/SAM binding site; other site
690850011353	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
690850011354	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
690850011355	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850011356	FeS/SAM binding site; other site
690850011357	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
690850011358	Ligand binding site; other site
690850011359	Putative Catalytic site; other site
690850011360	DXD motif; other site
690850011361	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
690850011362	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
690850011363	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
690850011364	putative acyl-acceptor binding pocket; other site
690850011365	Phosphopantetheine attachment site; Region: PP-binding; cl09936
690850011366	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
690850011367	3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691
690850011368	dimer interface [polypeptide binding]; other site
690850011369	active site
690850011370	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
690850011371	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
690850011372	active site
690850011373	catalytic triad [active]
690850011374	oxyanion hole [active]
690850011375	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
690850011376	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
690850011377	domain interfaces; other site
690850011378	active site
690850011379	Protein of unknown function, DUF399; Region: DUF399; pfam04187
690850011380	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
690850011381	Zn binding site [ion binding]; other site
690850011382	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
690850011383	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
690850011384	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
690850011385	Surface antigen; Region: Bac_surface_Ag; pfam01103
690850011386	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
690850011387	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
690850011388	Family of unknown function (DUF490); Region: DUF490; pfam04357
690850011389	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
690850011390	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
690850011391	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
690850011392	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
690850011393	anti sigma factor interaction site; other site
690850011394	regulatory phosphorylation site [posttranslational modification]; other site
690850011395	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
690850011396	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
690850011397	ATP binding site [chemical binding]; other site
690850011398	Mg2+ binding site [ion binding]; other site
690850011399	G-X-G motif; other site
690850011400	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
690850011401	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
690850011402	ligand binding site [chemical binding]; other site
690850011403	flexible hinge region; other site
690850011404	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
690850011405	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
690850011406	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
690850011407	Walker A/P-loop; other site
690850011408	ATP binding site [chemical binding]; other site
690850011409	Q-loop/lid; other site
690850011410	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
690850011411	ABC transporter signature motif; other site
690850011412	Walker B; other site
690850011413	D-loop; other site
690850011414	H-loop/switch region; other site
690850011415	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
690850011416	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
690850011417	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
690850011418	4Fe-4S binding domain; Region: Fer4; cl02805
690850011419	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
690850011420	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
690850011421	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
690850011422	molybdopterin cofactor binding site; other site
690850011423	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
690850011424	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
690850011425	heme-binding residues [chemical binding]; other site
690850011426	Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579
690850011427	putative ligand binding site [chemical binding]; other site
690850011428	putative catalytic site [active]
690850011429	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
690850011430	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
690850011431	active site
690850011432	Methyltransferase domain; Region: Methyltransf_31; pfam13847
690850011433	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850011434	S-adenosylmethionine binding site [chemical binding]; other site
690850011435	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
690850011436	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
690850011437	Probable Catalytic site; other site
690850011438	metal-binding site
690850011439	Methyltransferase domain; Region: Methyltransf_24; pfam13578
690850011440	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
690850011441	Trm112p-like protein; Region: Trm112p; cl01066
690850011442	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850011443	S-adenosylmethionine binding site [chemical binding]; other site
690850011444	Radical SAM superfamily; Region: Radical_SAM; pfam04055
690850011445	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850011446	FeS/SAM binding site; other site
690850011447	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
690850011448	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
690850011449	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
690850011450	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
690850011451	active site
690850011452	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
690850011453	dimer interface [polypeptide binding]; other site
690850011454	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
690850011455	Ligand Binding Site [chemical binding]; other site
690850011456	Molecular Tunnel; other site
690850011457	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
690850011458	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
690850011459	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
690850011460	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
690850011461	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
690850011462	TPP-binding site [chemical binding]; other site
690850011463	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
690850011464	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
690850011465	dimer interface [polypeptide binding]; other site
690850011466	PYR/PP interface [polypeptide binding]; other site
690850011467	TPP binding site [chemical binding]; other site
690850011468	substrate binding site [chemical binding]; other site
690850011469	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
690850011470	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
690850011471	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
690850011472	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
690850011473	Walker A/P-loop; other site
690850011474	ATP binding site [chemical binding]; other site
690850011475	Q-loop/lid; other site
690850011476	ABC transporter signature motif; other site
690850011477	Walker B; other site
690850011478	D-loop; other site
690850011479	H-loop/switch region; other site
690850011480	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
690850011481	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
690850011482	substrate binding pocket [chemical binding]; other site
690850011483	membrane-bound complex binding site; other site
690850011484	hinge residues; other site
690850011485	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
690850011486	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850011487	dimer interface [polypeptide binding]; other site
690850011488	conserved gate region; other site
690850011489	putative PBP binding loops; other site
690850011490	ABC-ATPase subunit interface; other site
690850011491	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
690850011492	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
690850011493	dimer interface [polypeptide binding]; other site
690850011494	conserved gate region; other site
690850011495	putative PBP binding loops; other site
690850011496	ABC-ATPase subunit interface; other site
690850011497	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
690850011498	intersubunit interface [polypeptide binding]; other site
690850011499	active site
690850011500	catalytic residue [active]
690850011501	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
690850011502	Precorrin-8X methylmutase; Region: CbiC; pfam02570
690850011503	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
690850011504	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
690850011505	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
690850011506	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
690850011507	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
690850011508	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
690850011509	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
690850011510	Soluble P-type ATPase [General function prediction only]; Region: COG4087
690850011511	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
690850011512	Transposase; Region: DEDD_Tnp_IS110; pfam01548
690850011513	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
690850011514	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
690850011515	MarR family; Region: MarR; pfam01047
690850011516	Cytochrome c; Region: Cytochrom_C; cl11414
690850011517	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
690850011518	CoenzymeA binding site [chemical binding]; other site
690850011519	subunit interaction site [polypeptide binding]; other site
690850011520	PHB binding site; other site
690850011521	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
690850011522	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
690850011523	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
690850011524	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
690850011525	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471
690850011526	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
690850011527	FlgN protein; Region: FlgN; pfam05130
690850011528	Rod binding protein; Region: Rod-binding; pfam10135
690850011529	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
690850011530	Peptidase family M23; Region: Peptidase_M23; pfam01551
690850011531	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
690850011532	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
690850011533	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696
690850011534	Flagellar L-ring protein; Region: FlgH; pfam02107
690850011535	SAF-like; Region: SAF_2; pfam13144
690850011536	flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170
690850011537	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
690850011538	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
690850011539	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
690850011540	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
690850011541	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
690850011542	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
690850011543	ribosome maturation protein RimP; Reviewed; Region: PRK00092
690850011544	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
690850011545	putative oligomer interface [polypeptide binding]; other site
690850011546	putative RNA binding site [nucleotide binding]; other site
690850011547	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
690850011548	NusA N-terminal domain; Region: NusA_N; pfam08529
690850011549	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
690850011550	RNA binding site [nucleotide binding]; other site
690850011551	homodimer interface [polypeptide binding]; other site
690850011552	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
690850011553	G-X-X-G motif; other site
690850011554	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
690850011555	G-X-X-G motif; other site
690850011556	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189
690850011557	putative RNA binding cleft [nucleotide binding]; other site
690850011558	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
690850011559	translation initiation factor IF-2; Region: IF-2; TIGR00487
690850011560	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
690850011561	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
690850011562	G1 box; other site
690850011563	putative GEF interaction site [polypeptide binding]; other site
690850011564	GTP/Mg2+ binding site [chemical binding]; other site
690850011565	Switch I region; other site
690850011566	G2 box; other site
690850011567	G3 box; other site
690850011568	Switch II region; other site
690850011569	G4 box; other site
690850011570	G5 box; other site
690850011571	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
690850011572	Translation-initiation factor 2; Region: IF-2; pfam11987
690850011573	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
690850011574	Protein of unknown function (DUF503); Region: DUF503; pfam04456
690850011575	Ribosome-binding factor A; Region: RBFA; pfam02033
690850011576	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
690850011577	DHH family; Region: DHH; pfam01368
690850011578	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
690850011579	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
690850011580	RNA binding site [nucleotide binding]; other site
690850011581	active site
690850011582	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
690850011583	16S/18S rRNA binding site [nucleotide binding]; other site
690850011584	S13e-L30e interaction site [polypeptide binding]; other site
690850011585	25S rRNA binding site [nucleotide binding]; other site
690850011586	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
690850011587	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
690850011588	RNase E interface [polypeptide binding]; other site
690850011589	trimer interface [polypeptide binding]; other site
690850011590	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
690850011591	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
690850011592	RNase E interface [polypeptide binding]; other site
690850011593	trimer interface [polypeptide binding]; other site
690850011594	active site
690850011595	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
690850011596	putative nucleic acid binding region [nucleotide binding]; other site
690850011597	G-X-X-G motif; other site
690850011598	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
690850011599	RNA binding site [nucleotide binding]; other site
690850011600	domain interface; other site
690850011601	Predicted metalloprotease [General function prediction only]; Region: COG2321
690850011602	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
690850011603	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
690850011604	putative ligand binding pocket/active site [active]
690850011605	putative metal binding site [ion binding]; other site
690850011606	Outer membrane lipoprotein; Region: YfiO; pfam13525
690850011607	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850011608	binding surface
690850011609	TPR motif; other site
690850011610	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850011611	TPR motif; other site
690850011612	binding surface
690850011613	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
690850011614	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
690850011615	Walker A motif; other site
690850011616	ATP binding site [chemical binding]; other site
690850011617	Walker B motif; other site
690850011618	arginine finger; other site
690850011619	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
690850011620	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
690850011621	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
690850011622	putative GTP cyclohydrolase; Provisional; Region: PRK13674
690850011623	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
690850011624	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
690850011625	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850011626	S-adenosylmethionine binding site [chemical binding]; other site
690850011627	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
690850011628	lipoyl attachment site [posttranslational modification]; other site
690850011629	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
690850011630	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
690850011631	tetramer interface [polypeptide binding]; other site
690850011632	pyridoxal 5'-phosphate binding site [chemical binding]; other site
690850011633	catalytic residue [active]
690850011634	glycine dehydrogenase subunit 2; Validated; Region: PRK04366
690850011635	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
690850011636	catalytic residue [active]
690850011637	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
690850011638	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
690850011639	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
690850011640	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
690850011641	dimerization interface [polypeptide binding]; other site
690850011642	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
690850011643	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
690850011644	dimer interface [polypeptide binding]; other site
690850011645	putative CheW interface [polypeptide binding]; other site
690850011646	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
690850011647	30S subunit binding site; other site
690850011648	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
690850011649	RNA-binding motif; other site
690850011650	DNA-binding site [nucleotide binding]; DNA binding site
690850011651	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
690850011652	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
690850011653	catalytic residues [active]
690850011654	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
690850011655	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
690850011656	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
690850011657	FtsX-like permease family; Region: FtsX; pfam02687
690850011658	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
690850011659	FtsX-like permease family; Region: FtsX; pfam02687
690850011660	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
690850011661	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
690850011662	Walker A/P-loop; other site
690850011663	ATP binding site [chemical binding]; other site
690850011664	Q-loop/lid; other site
690850011665	ABC transporter signature motif; other site
690850011666	Walker B; other site
690850011667	D-loop; other site
690850011668	H-loop/switch region; other site
690850011669	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
690850011670	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
690850011671	HlyD family secretion protein; Region: HlyD_3; pfam13437
690850011672	Uncharacterized protein containing a Zn-ribbon (DUF2116); Region: DUF2116; cl01683
690850011673	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
690850011674	Ligand Binding Site [chemical binding]; other site
690850011675	hypothetical protein; Provisional; Region: PRK04164
690850011676	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
690850011677	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
690850011678	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
690850011679	Coenzyme A binding pocket [chemical binding]; other site
690850011680	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
690850011681	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
690850011682	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
690850011683	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
690850011684	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
690850011685	minor groove reading motif; other site
690850011686	helix-hairpin-helix signature motif; other site
690850011687	substrate binding pocket [chemical binding]; other site
690850011688	active site
690850011689	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
690850011690	quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908
690850011691	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
690850011692	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
690850011693	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
690850011694	substrate binding site [chemical binding]; other site
690850011695	ATP binding site [chemical binding]; other site
690850011696	Phosphotransferase enzyme family; Region: APH; pfam01636
690850011697	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
690850011698	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
690850011699	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
690850011700	active site
690850011701	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14337
690850011702	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
690850011703	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
690850011704	FeS/SAM binding site; other site
690850011705	Bifunctional nuclease; Region: DNase-RNase; pfam02577
690850011706	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
690850011707	active site
690850011708	hypothetical protein; Provisional; Region: PRK06361
690850011709	NAD-dependent deacetylase; Provisional; Region: PRK00481
690850011710	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
690850011711	NAD+ binding site [chemical binding]; other site
690850011712	substrate binding site [chemical binding]; other site
690850011713	Zn binding site [ion binding]; other site
690850011714	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
690850011715	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
690850011716	TolR protein; Region: tolR; TIGR02801
690850011717	TonB C terminal; Region: TonB_2; pfam13103
690850011718	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
690850011719	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
690850011720	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
690850011721	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
690850011722	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
690850011723	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
690850011724	ligand binding site [chemical binding]; other site
690850011725	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
690850011726	tetramer interfaces [polypeptide binding]; other site
690850011727	binuclear metal-binding site [ion binding]; other site
690850011728	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
690850011729	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
690850011730	Maf-like protein; Region: Maf; pfam02545
690850011731	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
690850011732	active site
690850011733	dimer interface [polypeptide binding]; other site
690850011734	putative outer membrane lipoprotein; Provisional; Region: PRK10510
690850011735	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
690850011736	ligand binding site [chemical binding]; other site
690850011737	hypothetical protein; Provisional; Region: PRK09256
690850011738	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
690850011739	7TM-HD extracellular; Region: 7TMR-HDED; pfam07697
690850011740	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
690850011741	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
690850011742	Zn2+ binding site [ion binding]; other site
690850011743	Mg2+ binding site [ion binding]; other site
690850011744	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
690850011745	PhoH-like protein; Region: PhoH; pfam02562
690850011746	Domain of unknown function (DUF814); Region: DUF814; pfam05670
690850011747	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
690850011748	Uncharacterized conserved protein [Function unknown]; Region: COG2014
690850011749	Domain of unknown function (DUF364); Region: DUF364; pfam04016
690850011750	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
690850011751	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
690850011752	S-adenosylmethionine binding site [chemical binding]; other site
690850011753	putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266
690850011754	YcaO-like family; Region: YcaO; pfam02624
690850011755	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
690850011756	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850011757	binding surface
690850011758	TPR motif; other site
690850011759	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
690850011760	DsrC like protein; Region: DsrC; pfam04358
690850011761	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
690850011762	TPR motif; other site
690850011763	binding surface
690850011764	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399
690850011765	active site residues [active]
690850011766	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801