-- dump date 20140619_064159 -- class Genbank::misc_feature -- table misc_feature_note -- id note 525146000001 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 525146000002 Peptidase family M23; Region: Peptidase_M23; pfam01551 525146000003 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 525146000004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 525146000005 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 525146000006 DnaA box-binding interface [nucleotide binding]; other site 525146000007 DNA polymerase III subunit beta; Provisional; Region: PRK14947 525146000008 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 525146000009 putative DNA binding surface [nucleotide binding]; other site 525146000010 dimer interface [polypeptide binding]; other site 525146000011 beta-clamp/clamp loader binding surface; other site 525146000012 beta-clamp/translesion DNA polymerase binding surface; other site 525146000013 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 525146000014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146000015 ATP binding site [chemical binding]; other site 525146000016 Mg2+ binding site [ion binding]; other site 525146000017 G-X-G motif; other site 525146000018 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 525146000019 anchoring element; other site 525146000020 dimer interface [polypeptide binding]; other site 525146000021 ATP binding site [chemical binding]; other site 525146000022 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 525146000023 active site 525146000024 putative metal-binding site [ion binding]; other site 525146000025 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 525146000026 DNA gyrase subunit A; Validated; Region: PRK05560 525146000027 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 525146000028 CAP-like domain; other site 525146000029 active site 525146000030 primary dimer interface [polypeptide binding]; other site 525146000031 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525146000032 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525146000033 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525146000034 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525146000035 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525146000036 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 525146000037 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 525146000038 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 525146000039 active site 525146000040 tetramer interface [polypeptide binding]; other site 525146000041 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525146000042 active site 525146000043 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 525146000044 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 525146000045 dimer interface [polypeptide binding]; other site 525146000046 motif 1; other site 525146000047 active site 525146000048 motif 2; other site 525146000049 motif 3; other site 525146000050 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 525146000051 anticodon binding site; other site 525146000052 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 525146000053 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 525146000054 dimer interface [polypeptide binding]; other site 525146000055 anticodon binding site; other site 525146000056 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 525146000057 homodimer interface [polypeptide binding]; other site 525146000058 motif 1; other site 525146000059 active site 525146000060 motif 2; other site 525146000061 GAD domain; Region: GAD; pfam02938 525146000062 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 525146000063 motif 3; other site 525146000064 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 525146000065 active site 525146000066 catalytic residues [active] 525146000067 metal binding site [ion binding]; metal-binding site 525146000068 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 525146000069 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 525146000070 putative active site [active] 525146000071 substrate binding site [chemical binding]; other site 525146000072 putative cosubstrate binding site; other site 525146000073 catalytic site [active] 525146000074 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 525146000075 substrate binding site [chemical binding]; other site 525146000076 Protein of unknown function DUF116; Region: DUF116; pfam01976 525146000077 NusB family; Region: NusB; pfam01029 525146000078 putative RNA binding site [nucleotide binding]; other site 525146000079 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 525146000080 ParB-like nuclease domain; Region: ParBc; pfam02195 525146000081 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 525146000082 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 525146000083 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 525146000084 P-loop; other site 525146000085 Magnesium ion binding site [ion binding]; other site 525146000086 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 525146000087 Magnesium ion binding site [ion binding]; other site 525146000088 Response regulator receiver domain; Region: Response_reg; pfam00072 525146000089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146000090 active site 525146000091 phosphorylation site [posttranslational modification] 525146000092 intermolecular recognition site; other site 525146000093 dimerization interface [polypeptide binding]; other site 525146000094 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 525146000095 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 525146000096 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 525146000097 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 525146000098 DNA binding residues [nucleotide binding] 525146000099 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 525146000100 NlpC/P60 family; Region: NLPC_P60; pfam00877 525146000101 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 525146000102 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 525146000103 Part of AAA domain; Region: AAA_19; pfam13245 525146000104 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 525146000105 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 525146000106 Peptidase family U32; Region: Peptidase_U32; pfam01136 525146000107 Peptidase family U32; Region: Peptidase_U32; cl03113 525146000108 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 525146000109 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 525146000110 putative NAD(P) binding site [chemical binding]; other site 525146000111 active site 525146000112 putative substrate binding site [chemical binding]; other site 525146000113 Integral membrane protein TerC family; Region: TerC; cl10468 525146000114 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 525146000115 Precorrin-8X methylmutase; Region: CbiC; pfam02570 525146000116 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 525146000117 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 525146000118 catalytic triad [active] 525146000119 YceG-like family; Region: YceG; pfam02618 525146000120 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 525146000121 dimerization interface [polypeptide binding]; other site 525146000122 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 525146000123 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 525146000124 active site 525146000125 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 525146000126 HIGH motif; other site 525146000127 dimer interface [polypeptide binding]; other site 525146000128 KMSKS motif; other site 525146000129 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 525146000130 Peptidase family M50; Region: Peptidase_M50; pfam02163 525146000131 active site 525146000132 putative substrate binding region [chemical binding]; other site 525146000133 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 525146000134 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG3366 525146000135 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 525146000136 RNA/DNA hybrid binding site [nucleotide binding]; other site 525146000137 active site 525146000138 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 525146000139 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146000140 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146000141 dimer interface [polypeptide binding]; other site 525146000142 putative CheW interface [polypeptide binding]; other site 525146000143 Adenosylhomocysteinase; Provisional; Region: PTZ00075 525146000144 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 525146000145 homotetramer interface [polypeptide binding]; other site 525146000146 ligand binding site [chemical binding]; other site 525146000147 catalytic site [active] 525146000148 NAD binding site [chemical binding]; other site 525146000149 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525146000150 dimerization interface [polypeptide binding]; other site 525146000151 putative DNA binding site [nucleotide binding]; other site 525146000152 putative Zn2+ binding site [ion binding]; other site 525146000153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146000154 S-adenosylmethionine binding site [chemical binding]; other site 525146000155 Protein of unknown function (DUF721); Region: DUF721; pfam05258 525146000156 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 525146000157 FAD binding domain; Region: FAD_binding_4; pfam01565 525146000158 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 525146000159 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525146000160 Cysteine-rich domain; Region: CCG; pfam02754 525146000161 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 525146000162 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 525146000163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146000164 catalytic residue [active] 525146000165 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 525146000166 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 525146000167 glutaminase; Reviewed; Region: PRK12356 525146000168 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 525146000169 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 525146000170 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 525146000171 conserved cys residue [active] 525146000172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525146000173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525146000174 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 525146000175 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 525146000176 conserved cys residue [active] 525146000177 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 525146000178 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 525146000179 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 525146000180 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 525146000181 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 525146000182 RNase E interface [polypeptide binding]; other site 525146000183 trimer interface [polypeptide binding]; other site 525146000184 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 525146000185 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 525146000186 RNase E interface [polypeptide binding]; other site 525146000187 trimer interface [polypeptide binding]; other site 525146000188 active site 525146000189 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 525146000190 putative nucleic acid binding region [nucleotide binding]; other site 525146000191 G-X-X-G motif; other site 525146000192 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 525146000193 RNA binding site [nucleotide binding]; other site 525146000194 domain interface; other site 525146000195 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 525146000196 16S/18S rRNA binding site [nucleotide binding]; other site 525146000197 S13e-L30e interaction site [polypeptide binding]; other site 525146000198 25S rRNA binding site [nucleotide binding]; other site 525146000199 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 525146000200 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 525146000201 RNA binding site [nucleotide binding]; other site 525146000202 active site 525146000203 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 525146000204 DHH family; Region: DHH; pfam01368 525146000205 Protein of unknown function (DUF503); Region: DUF503; pfam04456 525146000206 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 525146000207 translation initiation factor IF-2; Region: IF-2; TIGR00487 525146000208 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 525146000209 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 525146000210 G1 box; other site 525146000211 putative GEF interaction site [polypeptide binding]; other site 525146000212 GTP/Mg2+ binding site [chemical binding]; other site 525146000213 Switch I region; other site 525146000214 G2 box; other site 525146000215 G3 box; other site 525146000216 Switch II region; other site 525146000217 G4 box; other site 525146000218 G5 box; other site 525146000219 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 525146000220 Translation-initiation factor 2; Region: IF-2; pfam11987 525146000221 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 525146000222 Protein of unknown function (DUF448); Region: DUF448; pfam04296 525146000223 putative RNA binding cleft [nucleotide binding]; other site 525146000224 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 525146000225 NusA N-terminal domain; Region: NusA_N; pfam08529 525146000226 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 525146000227 RNA binding site [nucleotide binding]; other site 525146000228 homodimer interface [polypeptide binding]; other site 525146000229 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 525146000230 G-X-X-G motif; other site 525146000231 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 525146000232 G-X-X-G motif; other site 525146000233 ribosome maturation protein RimP; Reviewed; Region: PRK00092 525146000234 Sm and related proteins; Region: Sm_like; cl00259 525146000235 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 525146000236 putative oligomer interface [polypeptide binding]; other site 525146000237 putative RNA binding site [nucleotide binding]; other site 525146000238 PAS domain; Region: PAS_9; pfam13426 525146000239 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146000240 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146000241 dimer interface [polypeptide binding]; other site 525146000242 putative CheW interface [polypeptide binding]; other site 525146000243 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 525146000244 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 525146000245 minor groove reading motif; other site 525146000246 helix-hairpin-helix signature motif; other site 525146000247 substrate binding pocket [chemical binding]; other site 525146000248 active site 525146000249 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 525146000250 active site 525146000251 8-oxo-dGMP binding site [chemical binding]; other site 525146000252 nudix motif; other site 525146000253 metal binding site [ion binding]; metal-binding site 525146000254 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 525146000255 substrate binding site [chemical binding]; other site 525146000256 DinB superfamily; Region: DinB_2; pfam12867 525146000257 Uncharacterized conserved protein [Function unknown]; Region: COG2353 525146000258 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 525146000259 intersubunit interface [polypeptide binding]; other site 525146000260 active site 525146000261 Zn2+ binding site [ion binding]; other site 525146000262 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 525146000263 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 525146000264 Probable Catalytic site; other site 525146000265 metal-binding site 525146000266 thiamine monophosphate kinase; Provisional; Region: PRK05731 525146000267 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 525146000268 ATP binding site [chemical binding]; other site 525146000269 dimerization interface [polypeptide binding]; other site 525146000270 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 525146000271 Part of AAA domain; Region: AAA_19; pfam13245 525146000272 Family description; Region: UvrD_C_2; pfam13538 525146000273 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 525146000274 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 525146000275 putative active site [active] 525146000276 Mn binding site [ion binding]; other site 525146000277 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 525146000278 oligomerization interface [polypeptide binding]; other site 525146000279 active site 525146000280 metal binding site [ion binding]; metal-binding site 525146000281 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 525146000282 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 525146000283 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525146000284 ATP binding site [chemical binding]; other site 525146000285 putative Mg++ binding site [ion binding]; other site 525146000286 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525146000287 nucleotide binding region [chemical binding]; other site 525146000288 ATP-binding site [chemical binding]; other site 525146000289 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 525146000290 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 525146000291 catalytic site [active] 525146000292 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 525146000293 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 525146000294 trimer interface [polypeptide binding]; other site 525146000295 CoA binding site [chemical binding]; other site 525146000296 active site 525146000297 Predicted flavoprotein [General function prediction only]; Region: COG0431 525146000298 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 525146000299 Predicted thioesterase [General function prediction only]; Region: COG5496 525146000300 Cytochrome c552; Region: Cytochrom_C552; pfam02335 525146000301 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 525146000302 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 525146000303 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525146000304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525146000305 dimer interface [polypeptide binding]; other site 525146000306 phosphorylation site [posttranslational modification] 525146000307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146000308 ATP binding site [chemical binding]; other site 525146000309 Mg2+ binding site [ion binding]; other site 525146000310 G-X-G motif; other site 525146000311 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525146000312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146000313 active site 525146000314 phosphorylation site [posttranslational modification] 525146000315 intermolecular recognition site; other site 525146000316 dimerization interface [polypeptide binding]; other site 525146000317 Response regulator receiver domain; Region: Response_reg; pfam00072 525146000318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146000319 active site 525146000320 phosphorylation site [posttranslational modification] 525146000321 intermolecular recognition site; other site 525146000322 dimerization interface [polypeptide binding]; other site 525146000323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146000324 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525146000325 Walker A motif; other site 525146000326 ATP binding site [chemical binding]; other site 525146000327 Walker B motif; other site 525146000328 arginine finger; other site 525146000329 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 525146000330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525146000331 dimerization interface [polypeptide binding]; other site 525146000332 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146000333 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146000334 dimer interface [polypeptide binding]; other site 525146000335 putative CheW interface [polypeptide binding]; other site 525146000336 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 525146000337 IHF dimer interface [polypeptide binding]; other site 525146000338 IHF - DNA interface [nucleotide binding]; other site 525146000339 glutamate racemase; Provisional; Region: PRK00865 525146000340 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525146000341 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525146000342 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 525146000343 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 525146000344 putative active site [active] 525146000345 oxyanion strand; other site 525146000346 catalytic triad [active] 525146000347 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 525146000348 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 525146000349 substrate binding site [chemical binding]; other site 525146000350 glutamase interaction surface [polypeptide binding]; other site 525146000351 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 525146000352 Ligand Binding Site [chemical binding]; other site 525146000353 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 525146000354 adenylosuccinate lyase; Provisional; Region: PRK07492 525146000355 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 525146000356 tetramer interface [polypeptide binding]; other site 525146000357 active site 525146000358 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525146000359 active site 525146000360 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 525146000361 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 525146000362 SnoaL-like domain; Region: SnoaL_3; pfam13474 525146000363 putative hydratase; Provisional; Region: PRK11413 525146000364 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 525146000365 substrate binding site [chemical binding]; other site 525146000366 ligand binding site [chemical binding]; other site 525146000367 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 525146000368 substrate binding site [chemical binding]; other site 525146000369 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 525146000370 isocitrate dehydrogenase; Validated; Region: PRK06451 525146000371 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 525146000372 isopropylmalate/citramalate/homocitrate synthases; Region: LEU1_arch; TIGR02090 525146000373 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 525146000374 active site 525146000375 catalytic residues [active] 525146000376 metal binding site [ion binding]; metal-binding site 525146000377 Cache domain; Region: Cache_1; pfam02743 525146000378 RNB domain; Region: RNB; pfam00773 525146000379 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 525146000380 membrane protein; Provisional; Region: PRK14397 525146000381 threonine synthase; Validated; Region: PRK06260 525146000382 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 525146000383 homodimer interface [polypeptide binding]; other site 525146000384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146000385 catalytic residue [active] 525146000386 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 525146000387 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 525146000388 Bacterial sugar transferase; Region: Bac_transf; pfam02397 525146000389 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525146000390 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 525146000391 putative ADP-binding pocket [chemical binding]; other site 525146000392 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 525146000393 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 525146000394 NAD binding site [chemical binding]; other site 525146000395 substrate binding site [chemical binding]; other site 525146000396 homodimer interface [polypeptide binding]; other site 525146000397 active site 525146000398 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 525146000399 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 525146000400 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 525146000401 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 525146000402 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 525146000403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525146000404 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 525146000405 active site 525146000406 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 525146000407 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 525146000408 catalytic residues [active] 525146000409 glycine/sarcosine/betaine reductase complex protein A; Reviewed; Region: PRK13265 525146000410 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146000411 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146000412 dimer interface [polypeptide binding]; other site 525146000413 putative CheW interface [polypeptide binding]; other site 525146000414 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 525146000415 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525146000416 Zn2+ binding site [ion binding]; other site 525146000417 Mg2+ binding site [ion binding]; other site 525146000418 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 525146000419 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 525146000420 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 525146000421 NodB motif; other site 525146000422 active site 525146000423 catalytic site [active] 525146000424 metal binding site [ion binding]; metal-binding site 525146000425 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 525146000426 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 525146000427 dimer interface [polypeptide binding]; other site 525146000428 active site 525146000429 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525146000430 catalytic residues [active] 525146000431 substrate binding site [chemical binding]; other site 525146000432 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 525146000433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525146000434 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 525146000435 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 525146000436 active site 525146000437 Zn binding site [ion binding]; other site 525146000438 thymidylate kinase; Validated; Region: tmk; PRK00698 525146000439 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 525146000440 TMP-binding site; other site 525146000441 ATP-binding site [chemical binding]; other site 525146000442 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 525146000443 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 525146000444 generic binding surface I; other site 525146000445 generic binding surface II; other site 525146000446 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525146000447 Zn2+ binding site [ion binding]; other site 525146000448 Mg2+ binding site [ion binding]; other site 525146000449 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 525146000450 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 525146000451 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 525146000452 intersubunit interface [polypeptide binding]; other site 525146000453 active site 525146000454 zinc binding site [ion binding]; other site 525146000455 Na+ binding site [ion binding]; other site 525146000456 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 525146000457 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 525146000458 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 525146000459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525146000460 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 525146000461 NAD(P) binding site [chemical binding]; other site 525146000462 active site 525146000463 Cache domain; Region: Cache_1; pfam02743 525146000464 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146000465 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146000466 dimer interface [polypeptide binding]; other site 525146000467 putative CheW interface [polypeptide binding]; other site 525146000468 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 525146000469 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 525146000470 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 525146000471 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 525146000472 TPP-binding site [chemical binding]; other site 525146000473 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 525146000474 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 525146000475 dimer interface [polypeptide binding]; other site 525146000476 PYR/PP interface [polypeptide binding]; other site 525146000477 TPP binding site [chemical binding]; other site 525146000478 substrate binding site [chemical binding]; other site 525146000479 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525146000480 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 525146000481 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 525146000482 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 525146000483 Flavoprotein; Region: Flavoprotein; pfam02441 525146000484 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 525146000485 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 525146000486 HEAT-like repeat; Region: HEAT_EZ; pfam13513 525146000487 M28 Zn-Peptidases; Region: M28_like_3; cd05644 525146000488 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 525146000489 active site 525146000490 metal binding site [ion binding]; metal-binding site 525146000491 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 525146000492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146000493 active site 525146000494 phosphorylation site [posttranslational modification] 525146000495 intermolecular recognition site; other site 525146000496 dimerization interface [polypeptide binding]; other site 525146000497 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 525146000498 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 525146000499 dimer interface [polypeptide binding]; other site 525146000500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146000501 catalytic residue [active] 525146000502 SnoaL-like domain; Region: SnoaL_3; pfam13474 525146000503 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 525146000504 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525146000505 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 525146000506 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 525146000507 lipoyl attachment site [posttranslational modification]; other site 525146000508 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 525146000509 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 525146000510 Na binding site [ion binding]; other site 525146000511 FOG: CBS domain [General function prediction only]; Region: COG0517 525146000512 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 525146000513 PAS fold; Region: PAS_4; pfam08448 525146000514 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 525146000515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146000516 Walker A motif; other site 525146000517 ATP binding site [chemical binding]; other site 525146000518 Walker B motif; other site 525146000519 arginine finger; other site 525146000520 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 525146000521 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 525146000522 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 525146000523 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 525146000524 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 525146000525 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 525146000526 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 525146000527 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 525146000528 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 525146000529 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 525146000530 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 525146000531 rod shape-determining protein MreC; Provisional; Region: PRK13922 525146000532 rod shape-determining protein MreC; Region: MreC; pfam04085 525146000533 rod shape-determining protein MreB; Provisional; Region: PRK13927 525146000534 MreB and similar proteins; Region: MreB_like; cd10225 525146000535 nucleotide binding site [chemical binding]; other site 525146000536 Mg binding site [ion binding]; other site 525146000537 putative protofilament interaction site [polypeptide binding]; other site 525146000538 RodZ interaction site [polypeptide binding]; other site 525146000539 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 525146000540 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 525146000541 HAMP domain; Region: HAMP; pfam00672 525146000542 dimerization interface [polypeptide binding]; other site 525146000543 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146000544 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146000545 dimer interface [polypeptide binding]; other site 525146000546 putative CheW interface [polypeptide binding]; other site 525146000547 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 525146000548 active site 525146000549 catalytic residues [active] 525146000550 Int/Topo IB signature motif; other site 525146000551 DNA binding site [nucleotide binding] 525146000552 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 525146000553 molybdenum-pterin binding domain; Region: Mop; TIGR00638 525146000554 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 525146000555 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 525146000556 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 525146000557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146000558 dimer interface [polypeptide binding]; other site 525146000559 conserved gate region; other site 525146000560 putative PBP binding loops; other site 525146000561 ABC-ATPase subunit interface; other site 525146000562 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525146000563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525146000564 Walker A/P-loop; other site 525146000565 ATP binding site [chemical binding]; other site 525146000566 Q-loop/lid; other site 525146000567 ABC transporter signature motif; other site 525146000568 Walker B; other site 525146000569 D-loop; other site 525146000570 H-loop/switch region; other site 525146000571 alanine racemase; Reviewed; Region: alr; PRK00053 525146000572 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 525146000573 active site 525146000574 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525146000575 dimer interface [polypeptide binding]; other site 525146000576 substrate binding site [chemical binding]; other site 525146000577 catalytic residues [active] 525146000578 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 525146000579 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 525146000580 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 525146000581 ligand binding site [chemical binding]; other site 525146000582 homodimer interface [polypeptide binding]; other site 525146000583 NAD(P) binding site [chemical binding]; other site 525146000584 trimer interface B [polypeptide binding]; other site 525146000585 trimer interface A [polypeptide binding]; other site 525146000586 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 525146000587 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 525146000588 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 525146000589 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 525146000590 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 525146000591 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 525146000592 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 525146000593 Sel1-like repeats; Region: SEL1; smart00671 525146000594 Sel1-like repeats; Region: SEL1; smart00671 525146000595 Sel1-like repeats; Region: SEL1; smart00671 525146000596 CGGC domain; Region: CGGC; cl02356 525146000597 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 525146000598 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 525146000599 IHF - DNA interface [nucleotide binding]; other site 525146000600 IHF dimer interface [polypeptide binding]; other site 525146000601 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 525146000602 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146000603 FeS/SAM binding site; other site 525146000604 Cache domain; Region: Cache_1; pfam02743 525146000605 HAMP domain; Region: HAMP; pfam00672 525146000606 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146000607 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146000608 dimer interface [polypeptide binding]; other site 525146000609 putative CheW interface [polypeptide binding]; other site 525146000610 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 525146000611 sensor protein ZraS; Provisional; Region: PRK10364 525146000612 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525146000613 phosphorylation site [posttranslational modification] 525146000614 dimer interface [polypeptide binding]; other site 525146000615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146000616 ATP binding site [chemical binding]; other site 525146000617 G-X-G motif; other site 525146000618 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525146000619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146000620 active site 525146000621 phosphorylation site [posttranslational modification] 525146000622 intermolecular recognition site; other site 525146000623 dimerization interface [polypeptide binding]; other site 525146000624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146000625 Walker A motif; other site 525146000626 ATP binding site [chemical binding]; other site 525146000627 Walker B motif; other site 525146000628 arginine finger; other site 525146000629 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525146000630 HD domain; Region: HD_3; pfam13023 525146000631 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146000632 metal binding site [ion binding]; metal-binding site 525146000633 active site 525146000634 I-site; other site 525146000635 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 525146000636 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 525146000637 nucleotide binding site [chemical binding]; other site 525146000638 N-acetyl-L-glutamate binding site [chemical binding]; other site 525146000639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525146000640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525146000641 dimer interface [polypeptide binding]; other site 525146000642 phosphorylation site [posttranslational modification] 525146000643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146000644 ATP binding site [chemical binding]; other site 525146000645 Mg2+ binding site [ion binding]; other site 525146000646 G-X-G motif; other site 525146000647 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525146000648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146000649 active site 525146000650 phosphorylation site [posttranslational modification] 525146000651 intermolecular recognition site; other site 525146000652 dimerization interface [polypeptide binding]; other site 525146000653 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 525146000654 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 525146000655 HIGH motif; other site 525146000656 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 525146000657 active site 525146000658 KMSKS motif; other site 525146000659 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 525146000660 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 525146000661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525146000662 putative substrate translocation pore; other site 525146000663 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 525146000664 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525146000665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146000666 active site 525146000667 phosphorylation site [posttranslational modification] 525146000668 intermolecular recognition site; other site 525146000669 dimerization interface [polypeptide binding]; other site 525146000670 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 525146000671 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 525146000672 minor groove reading motif; other site 525146000673 helix-hairpin-helix signature motif; other site 525146000674 substrate binding pocket [chemical binding]; other site 525146000675 active site 525146000676 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 525146000677 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 525146000678 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 525146000679 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 525146000680 substrate binding site [chemical binding]; other site 525146000681 ATP binding site [chemical binding]; other site 525146000682 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 525146000683 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 525146000684 active site 525146000685 Protein of unknown function, DUF606; Region: DUF606; pfam04657 525146000686 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 525146000687 putative deacylase active site [active] 525146000688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 525146000689 Cupin domain; Region: Cupin_2; pfam07883 525146000690 Mechanosensitive ion channel; Region: MS_channel; pfam00924 525146000691 Uncharacterized conserved protein [Function unknown]; Region: COG2006 525146000692 Domain of unknown function (DUF362); Region: DUF362; pfam04015 525146000693 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 525146000694 thiamine phosphate binding site [chemical binding]; other site 525146000695 active site 525146000696 pyrophosphate binding site [ion binding]; other site 525146000697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 525146000698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 525146000699 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 525146000700 dimerization interface [polypeptide binding]; other site 525146000701 LrgA family; Region: LrgA; pfam03788 525146000702 LrgB-like family; Region: LrgB; pfam04172 525146000703 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 525146000704 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 525146000705 ligand binding site [chemical binding]; other site 525146000706 homodimer interface [polypeptide binding]; other site 525146000707 NAD(P) binding site [chemical binding]; other site 525146000708 trimer interface B [polypeptide binding]; other site 525146000709 trimer interface A [polypeptide binding]; other site 525146000710 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 525146000711 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 525146000712 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 525146000713 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 525146000714 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 525146000715 aminotransferase; Validated; Region: PRK07678 525146000716 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 525146000717 inhibitor-cofactor binding pocket; inhibition site 525146000718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146000719 catalytic residue [active] 525146000720 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525146000721 Sedlin, N-terminal conserved region; Region: Sedlin_N; cl17809 525146000722 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525146000723 putative active site [active] 525146000724 heme pocket [chemical binding]; other site 525146000725 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 525146000726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146000727 Walker A motif; other site 525146000728 ATP binding site [chemical binding]; other site 525146000729 Walker B motif; other site 525146000730 arginine finger; other site 525146000731 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525146000732 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 525146000733 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 525146000734 PYR/PP interface [polypeptide binding]; other site 525146000735 dimer interface [polypeptide binding]; other site 525146000736 TPP binding site [chemical binding]; other site 525146000737 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 525146000738 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 525146000739 TPP-binding site [chemical binding]; other site 525146000740 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 525146000741 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 525146000742 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 525146000743 active site 525146000744 catalytic residues [active] 525146000745 DNA binding site [nucleotide binding] 525146000746 Int/Topo IB signature motif; other site 525146000747 BRO family, N-terminal domain; Region: Bro-N; pfam02498 525146000748 Protein of unknown function (DUF497); Region: DUF497; pfam04365 525146000749 Haemolytic domain; Region: Haemolytic; pfam01809 525146000750 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 525146000751 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 525146000752 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 525146000753 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 525146000754 Phage-related protein [Function unknown]; Region: COG4695; cl01923 525146000755 Phage portal protein; Region: Phage_portal; pfam04860 525146000756 terminase ATPase subunit; Provisional; Region: P; PHA02535 525146000757 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 525146000758 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 525146000759 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 525146000760 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 525146000761 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 525146000762 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 525146000763 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 525146000764 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 525146000765 Peptidase M15; Region: Peptidase_M15_3; cl01194 525146000766 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 525146000767 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 525146000768 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 525146000769 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 525146000770 Baseplate J-like protein; Region: Baseplate_J; cl01294 525146000771 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 525146000772 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 525146000773 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 525146000774 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525146000775 active site 525146000776 HIGH motif; other site 525146000777 nucleotide binding site [chemical binding]; other site 525146000778 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 525146000779 KMSKS motif; other site 525146000780 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 525146000781 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525146000782 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 525146000783 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 525146000784 additional DNA contacts [nucleotide binding]; other site 525146000785 mismatch recognition site; other site 525146000786 active site 525146000787 zinc binding site [ion binding]; other site 525146000788 DNA intercalation site [nucleotide binding]; other site 525146000789 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 525146000790 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 525146000791 cofactor binding site; other site 525146000792 DNA binding site [nucleotide binding] 525146000793 substrate interaction site [chemical binding]; other site 525146000794 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 525146000795 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 525146000796 cofactor binding site; other site 525146000797 DNA binding site [nucleotide binding] 525146000798 substrate interaction site [chemical binding]; other site 525146000799 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 525146000800 HNH endonuclease; Region: HNH_2; pfam13391 525146000801 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 525146000802 HTH-like domain; Region: HTH_21; pfam13276 525146000803 Integrase core domain; Region: rve; pfam00665 525146000804 Integrase core domain; Region: rve_3; pfam13683 525146000805 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 525146000806 DNA-binding interface [nucleotide binding]; DNA binding site 525146000807 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146000808 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146000809 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146000810 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146000811 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146000812 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146000813 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146000814 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146000815 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146000816 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 525146000817 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 525146000818 putative ligand binding site [chemical binding]; other site 525146000819 putative NAD binding site [chemical binding]; other site 525146000820 catalytic site [active] 525146000821 serine O-acetyltransferase; Region: cysE; TIGR01172 525146000822 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 525146000823 trimer interface [polypeptide binding]; other site 525146000824 active site 525146000825 substrate binding site [chemical binding]; other site 525146000826 CoA binding site [chemical binding]; other site 525146000827 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 525146000828 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 525146000829 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 525146000830 Catalytic site [active] 525146000831 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 525146000832 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 525146000833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146000834 Walker A motif; other site 525146000835 ATP binding site [chemical binding]; other site 525146000836 Walker B motif; other site 525146000837 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 525146000838 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 525146000839 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 525146000840 Cache domain; Region: Cache_1; pfam02743 525146000841 HAMP domain; Region: HAMP; pfam00672 525146000842 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146000843 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146000844 dimer interface [polypeptide binding]; other site 525146000845 putative CheW interface [polypeptide binding]; other site 525146000846 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 525146000847 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 525146000848 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 525146000849 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146000850 FeS/SAM binding site; other site 525146000851 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 525146000852 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 525146000853 dimer interface [polypeptide binding]; other site 525146000854 active site 525146000855 Schiff base residues; other site 525146000856 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 525146000857 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146000858 FeS/SAM binding site; other site 525146000859 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 525146000860 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 525146000861 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 525146000862 motif 1; other site 525146000863 active site 525146000864 motif 2; other site 525146000865 motif 3; other site 525146000866 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 525146000867 DHHA1 domain; Region: DHHA1; pfam02272 525146000868 recombinase A; Provisional; Region: recA; PRK09354 525146000869 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 525146000870 hexamer interface [polypeptide binding]; other site 525146000871 Walker A motif; other site 525146000872 ATP binding site [chemical binding]; other site 525146000873 Walker B motif; other site 525146000874 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 525146000875 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 525146000876 Ligand Binding Site [chemical binding]; other site 525146000877 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 525146000878 Domain of unknown function (DUF814); Region: DUF814; pfam05670 525146000879 Benzoate membrane transport protein; Region: BenE; pfam03594 525146000880 benzoate transporter; Region: benE; TIGR00843 525146000881 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 525146000882 propionate/acetate kinase; Provisional; Region: PRK12379 525146000883 phosphate acetyltransferase; Reviewed; Region: PRK05632 525146000884 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525146000885 DRTGG domain; Region: DRTGG; pfam07085 525146000886 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 525146000887 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 525146000888 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 525146000889 dimer interface [polypeptide binding]; other site 525146000890 PYR/PP interface [polypeptide binding]; other site 525146000891 TPP binding site [chemical binding]; other site 525146000892 substrate binding site [chemical binding]; other site 525146000893 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 525146000894 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 525146000895 Domain of unknown function; Region: EKR; smart00890 525146000896 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525146000897 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 525146000898 TPP-binding site [chemical binding]; other site 525146000899 dimer interface [polypeptide binding]; other site 525146000900 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 525146000901 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 525146000902 dimerization interface [polypeptide binding]; other site 525146000903 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146000904 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146000905 dimer interface [polypeptide binding]; other site 525146000906 putative CheW interface [polypeptide binding]; other site 525146000907 Cache domain; Region: Cache_1; pfam02743 525146000908 HAMP domain; Region: HAMP; pfam00672 525146000909 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146000910 dimer interface [polypeptide binding]; other site 525146000911 putative CheW interface [polypeptide binding]; other site 525146000912 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 525146000913 DNA topoisomerase I; Validated; Region: PRK06599 525146000914 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 525146000915 active site 525146000916 interdomain interaction site; other site 525146000917 putative metal-binding site [ion binding]; other site 525146000918 nucleotide binding site [chemical binding]; other site 525146000919 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 525146000920 domain I; other site 525146000921 DNA binding groove [nucleotide binding] 525146000922 phosphate binding site [ion binding]; other site 525146000923 domain II; other site 525146000924 domain III; other site 525146000925 nucleotide binding site [chemical binding]; other site 525146000926 catalytic site [active] 525146000927 domain IV; other site 525146000928 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 525146000929 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 525146000930 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 525146000931 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 525146000932 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 525146000933 XdhC Rossmann domain; Region: XdhC_C; pfam13478 525146000934 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 525146000935 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525146000936 HlyD family secretion protein; Region: HlyD_3; pfam13437 525146000937 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 525146000938 Protein export membrane protein; Region: SecD_SecF; cl14618 525146000939 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 525146000940 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 525146000941 lysozyme catalytic cleft [active] 525146000942 lysozyme catalytic site [active] 525146000943 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 525146000944 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 525146000945 putative active site [active] 525146000946 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 525146000947 ATP binding site [chemical binding]; other site 525146000948 active site 525146000949 substrate binding site [chemical binding]; other site 525146000950 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 525146000951 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 525146000952 Cl- selectivity filter; other site 525146000953 Cl- binding residues [ion binding]; other site 525146000954 pore gating glutamate residue; other site 525146000955 dimer interface [polypeptide binding]; other site 525146000956 H+/Cl- coupling transport residue; other site 525146000957 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 525146000958 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525146000959 acyl-activating enzyme (AAE) consensus motif; other site 525146000960 AMP binding site [chemical binding]; other site 525146000961 active site 525146000962 CoA binding site [chemical binding]; other site 525146000963 Uncharacterized ArCR, COG2043; Region: DUF169; cl00894 525146000964 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 525146000965 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 525146000966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146000967 active site 525146000968 phosphorylation site [posttranslational modification] 525146000969 intermolecular recognition site; other site 525146000970 dimerization interface [polypeptide binding]; other site 525146000971 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 525146000972 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 525146000973 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 525146000974 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 525146000975 DNA binding residues [nucleotide binding] 525146000976 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 525146000977 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 525146000978 P-loop; other site 525146000979 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 525146000980 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 525146000981 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 525146000982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 525146000983 Walker A motif; other site 525146000984 ATP binding site [chemical binding]; other site 525146000985 Walker B motif; other site 525146000986 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 525146000987 non-specific DNA binding site [nucleotide binding]; other site 525146000988 salt bridge; other site 525146000989 sequence-specific DNA binding site [nucleotide binding]; other site 525146000990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525146000991 non-specific DNA binding site [nucleotide binding]; other site 525146000992 salt bridge; other site 525146000993 sequence-specific DNA binding site [nucleotide binding]; other site 525146000994 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 525146000995 FHIPEP family; Region: FHIPEP; pfam00771 525146000996 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 525146000997 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 525146000998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525146000999 putative substrate translocation pore; other site 525146001000 Major Facilitator Superfamily; Region: MFS_1; pfam07690 525146001001 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 525146001002 prephenate dehydrogenase; Provisional; Region: PRK06444 525146001003 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 525146001004 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 525146001005 hinge; other site 525146001006 active site 525146001007 Chorismate mutase type II; Region: CM_2; pfam01817 525146001008 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 525146001009 Prephenate dehydratase; Region: PDT; pfam00800 525146001010 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 525146001011 putative L-Phe binding site [chemical binding]; other site 525146001012 3-dehydroquinate synthase; Provisional; Region: PRK02290 525146001013 Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465 525146001014 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 525146001015 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 525146001016 putative active site; other site 525146001017 catalytic residue [active] 525146001018 D-cysteine desulfhydrase; Validated; Region: PRK03910 525146001019 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 525146001020 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525146001021 catalytic residue [active] 525146001022 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 525146001023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525146001024 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 525146001025 DNA-binding site [nucleotide binding]; DNA binding site 525146001026 FCD domain; Region: FCD; pfam07729 525146001027 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 525146001028 DHH family; Region: DHH; pfam01368 525146001029 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 525146001030 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 525146001031 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 525146001032 Peptidase M16C associated; Region: M16C_assoc; pfam08367 525146001033 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 525146001034 rRNA interaction site [nucleotide binding]; other site 525146001035 S8 interaction site; other site 525146001036 putative laminin-1 binding site; other site 525146001037 elongation factor Ts; Provisional; Region: tsf; PRK09377 525146001038 UBA/TS-N domain; Region: UBA; pfam00627 525146001039 Elongation factor TS; Region: EF_TS; pfam00889 525146001040 Elongation factor TS; Region: EF_TS; pfam00889 525146001041 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 525146001042 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 525146001043 Transporter associated domain; Region: CorC_HlyC; smart01091 525146001044 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 525146001045 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146001046 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146001047 dimer interface [polypeptide binding]; other site 525146001048 putative CheW interface [polypeptide binding]; other site 525146001049 AAA domain; Region: AAA_17; pfam13207 525146001050 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525146001051 catalytic core [active] 525146001052 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 525146001053 aspartate racemase; Region: asp_race; TIGR00035 525146001054 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 525146001055 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 525146001056 active site 525146001057 HIGH motif; other site 525146001058 dimer interface [polypeptide binding]; other site 525146001059 KMSKS motif; other site 525146001060 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525146001061 RNA binding surface [nucleotide binding]; other site 525146001062 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525146001063 Flagellin N-methylase; Region: FliB; pfam03692 525146001064 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 525146001065 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 525146001066 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 525146001067 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 525146001068 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 525146001069 DEAD-like helicases superfamily; Region: DEXDc; smart00487 525146001070 ATP binding site [chemical binding]; other site 525146001071 putative Mg++ binding site [ion binding]; other site 525146001072 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525146001073 nucleotide binding region [chemical binding]; other site 525146001074 ATP-binding site [chemical binding]; other site 525146001075 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 525146001076 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 525146001077 active site 525146001078 Riboflavin kinase; Region: Flavokinase; pfam01687 525146001079 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 525146001080 histidinol-phosphatase; Provisional; Region: PRK07328 525146001081 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 525146001082 active site 525146001083 dimer interface [polypeptide binding]; other site 525146001084 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 525146001085 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 525146001086 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 525146001087 Herpesvirus glycoprotein M; Region: Herpes_glycop; cl17339 525146001088 Cytochrome c; Region: Cytochrom_C; pfam00034 525146001089 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 525146001090 GTPase Era; Reviewed; Region: era; PRK00089 525146001091 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 525146001092 G1 box; other site 525146001093 GTP/Mg2+ binding site [chemical binding]; other site 525146001094 Switch I region; other site 525146001095 G2 box; other site 525146001096 Switch II region; other site 525146001097 G3 box; other site 525146001098 G4 box; other site 525146001099 G5 box; other site 525146001100 KH domain; Region: KH_2; pfam07650 525146001101 G-X-X-G motif; other site 525146001102 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 525146001103 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525146001104 catalytic residue [active] 525146001105 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 525146001106 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 525146001107 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 525146001108 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 525146001109 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 525146001110 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 525146001111 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 525146001112 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 525146001113 N-acetyl-D-glucosamine binding site [chemical binding]; other site 525146001114 catalytic residue [active] 525146001115 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 525146001116 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 525146001117 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 525146001118 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 525146001119 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 525146001120 P-loop; other site 525146001121 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 525146001122 ACS interaction site; other site 525146001123 CODH interaction site; other site 525146001124 Prismane/CO dehydrogenase family; Region: Prismane; pfam03063 525146001125 cubane metal cluster (B-cluster) [ion binding]; other site 525146001126 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 525146001127 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 525146001128 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 525146001129 ligand binding site [chemical binding]; other site 525146001130 flexible hinge region; other site 525146001131 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 525146001132 putative switch regulator; other site 525146001133 non-specific DNA interactions [nucleotide binding]; other site 525146001134 DNA binding site [nucleotide binding] 525146001135 sequence specific DNA binding site [nucleotide binding]; other site 525146001136 putative cAMP binding site [chemical binding]; other site 525146001137 HupF/HypC family; Region: HupF_HypC; pfam01455 525146001138 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 525146001139 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525146001140 active site 525146001141 HIGH motif; other site 525146001142 nucleotide binding site [chemical binding]; other site 525146001143 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 525146001144 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 525146001145 active site 525146001146 KMSKS motif; other site 525146001147 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 525146001148 tRNA binding surface [nucleotide binding]; other site 525146001149 anticodon binding site; other site 525146001150 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 525146001151 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 525146001152 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 525146001153 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 525146001154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146001155 binding surface 525146001156 TPR motif; other site 525146001157 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 525146001158 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 525146001159 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 525146001160 FMN binding site [chemical binding]; other site 525146001161 dimer interface [polypeptide binding]; other site 525146001162 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 525146001163 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 525146001164 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 525146001165 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 525146001166 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 525146001167 SAF-like; Region: SAF_2; pfam13144 525146001168 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 525146001169 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 525146001170 Flagellar L-ring protein; Region: FlgH; pfam02107 525146001171 Homeodomain-like domain; Region: HTH_23; cl17451 525146001172 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525146001173 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525146001174 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525146001175 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 525146001176 putative ADP-binding pocket [chemical binding]; other site 525146001177 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 525146001178 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525146001179 active site 525146001180 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 525146001181 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 525146001182 active site 525146001183 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525146001184 active site 525146001185 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 525146001186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525146001187 active site 525146001188 Methyltransferase domain; Region: Methyltransf_31; pfam13847 525146001189 Methyltransferase domain; Region: Methyltransf_12; pfam08242 525146001190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146001191 S-adenosylmethionine binding site [chemical binding]; other site 525146001192 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 525146001193 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525146001194 catalytic residue [active] 525146001195 surface carbohydrate biosynthesis protein, LIC13510 family; Region: O_ant_LIC13510; TIGR04326 525146001196 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 525146001197 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 525146001198 trimer interface [polypeptide binding]; other site 525146001199 active site 525146001200 substrate binding site [chemical binding]; other site 525146001201 CoA binding site [chemical binding]; other site 525146001202 putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331 525146001203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 525146001204 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525146001205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525146001206 Walker A/P-loop; other site 525146001207 ATP binding site [chemical binding]; other site 525146001208 Q-loop/lid; other site 525146001209 ABC transporter signature motif; other site 525146001210 Walker B; other site 525146001211 D-loop; other site 525146001212 H-loop/switch region; other site 525146001213 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 525146001214 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 525146001215 NADP binding site [chemical binding]; other site 525146001216 active site 525146001217 putative substrate binding site [chemical binding]; other site 525146001218 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 525146001219 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 525146001220 NADP-binding site; other site 525146001221 homotetramer interface [polypeptide binding]; other site 525146001222 substrate binding site [chemical binding]; other site 525146001223 homodimer interface [polypeptide binding]; other site 525146001224 active site 525146001225 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 525146001226 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 525146001227 Substrate binding site; other site 525146001228 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 525146001229 phosphomannomutase CpsG; Provisional; Region: PRK15414 525146001230 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 525146001231 active site 525146001232 substrate binding site [chemical binding]; other site 525146001233 metal binding site [ion binding]; metal-binding site 525146001234 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 525146001235 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 525146001236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525146001237 putative substrate translocation pore; other site 525146001238 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 525146001239 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 525146001240 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 525146001241 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146001242 metal binding site [ion binding]; metal-binding site 525146001243 active site 525146001244 I-site; other site 525146001245 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 525146001246 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525146001247 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146001248 metal binding site [ion binding]; metal-binding site 525146001249 active site 525146001250 I-site; other site 525146001251 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 525146001252 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 525146001253 substrate-cofactor binding pocket; other site 525146001254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146001255 catalytic residue [active] 525146001256 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 525146001257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525146001258 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525146001259 Walker A/P-loop; other site 525146001260 ATP binding site [chemical binding]; other site 525146001261 Q-loop/lid; other site 525146001262 ABC transporter signature motif; other site 525146001263 Walker B; other site 525146001264 D-loop; other site 525146001265 H-loop/switch region; other site 525146001266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146001267 dimer interface [polypeptide binding]; other site 525146001268 conserved gate region; other site 525146001269 putative PBP binding loops; other site 525146001270 ABC-ATPase subunit interface; other site 525146001271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146001272 S-adenosylmethionine binding site [chemical binding]; other site 525146001273 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 525146001274 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 525146001275 N-terminal plug; other site 525146001276 ligand-binding site [chemical binding]; other site 525146001277 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 525146001278 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525146001279 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 525146001280 DNA-binding interface [nucleotide binding]; DNA binding site 525146001281 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 525146001282 HTH-like domain; Region: HTH_21; pfam13276 525146001283 Integrase core domain; Region: rve; pfam00665 525146001284 Integrase core domain; Region: rve_3; pfam13683 525146001285 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 525146001286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525146001287 non-specific DNA binding site [nucleotide binding]; other site 525146001288 salt bridge; other site 525146001289 sequence-specific DNA binding site [nucleotide binding]; other site 525146001290 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 525146001291 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 525146001292 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 525146001293 active site 525146001294 metal binding site [ion binding]; metal-binding site 525146001295 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 525146001296 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 525146001297 P-loop; other site 525146001298 Magnesium ion binding site [ion binding]; other site 525146001299 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 525146001300 Magnesium ion binding site [ion binding]; other site 525146001301 integrase; Provisional; Region: int; PHA02601 525146001302 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525146001303 active site 525146001304 DNA binding site [nucleotide binding] 525146001305 Int/Topo IB signature motif; other site 525146001306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146001307 TPR motif; other site 525146001308 binding surface 525146001309 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 525146001310 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 525146001311 active site 525146001312 (T/H)XGH motif; other site 525146001313 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 525146001314 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 525146001315 putative catalytic cysteine [active] 525146001316 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 525146001317 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 525146001318 dimer interface [polypeptide binding]; other site 525146001319 PYR/PP interface [polypeptide binding]; other site 525146001320 TPP binding site [chemical binding]; other site 525146001321 substrate binding site [chemical binding]; other site 525146001322 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 525146001323 TPP-binding site; other site 525146001324 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 525146001325 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14460 525146001326 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146001327 FeS/SAM binding site; other site 525146001328 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 525146001329 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 525146001330 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 525146001331 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 525146001332 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 525146001333 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 525146001334 4Fe-4S binding domain; Region: Fer4_6; pfam12837 525146001335 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 525146001336 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525146001337 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 525146001338 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 525146001339 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 525146001340 ATP-sulfurylase; Region: ATPS; cd00517 525146001341 active site 525146001342 HXXH motif; other site 525146001343 flexible loop; other site 525146001344 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 525146001345 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 525146001346 dimer interface [polypeptide binding]; other site 525146001347 ssDNA binding site [nucleotide binding]; other site 525146001348 tetramer (dimer of dimers) interface [polypeptide binding]; other site 525146001349 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 525146001350 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 525146001351 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 525146001352 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 525146001353 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 525146001354 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 525146001355 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 525146001356 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525146001357 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 525146001358 purine nucleoside phosphorylase; Provisional; Region: PRK08202 525146001359 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 525146001360 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 525146001361 G1 box; other site 525146001362 putative GEF interaction site [polypeptide binding]; other site 525146001363 GTP/Mg2+ binding site [chemical binding]; other site 525146001364 Switch I region; other site 525146001365 G2 box; other site 525146001366 G3 box; other site 525146001367 Switch II region; other site 525146001368 G4 box; other site 525146001369 G5 box; other site 525146001370 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 525146001371 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 525146001372 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 525146001373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525146001374 Coenzyme A binding pocket [chemical binding]; other site 525146001375 Family of unknown function (DUF490); Region: DUF490; pfam04357 525146001376 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 525146001377 Surface antigen; Region: Bac_surface_Ag; pfam01103 525146001378 DsrE/DsrF-like family; Region: DrsE; cl00672 525146001379 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 525146001380 substrate binding site [chemical binding]; other site 525146001381 multimerization interface [polypeptide binding]; other site 525146001382 ATP binding site [chemical binding]; other site 525146001383 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525146001384 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 525146001385 putative homodimer interface [polypeptide binding]; other site 525146001386 putative active site pocket [active] 525146001387 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 525146001388 N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795 525146001389 putative active site [active] 525146001390 catalytic site [active] 525146001391 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 525146001392 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 525146001393 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525146001394 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 525146001395 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 525146001396 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 525146001397 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 525146001398 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 525146001399 dimerization interface [polypeptide binding]; other site 525146001400 ligand binding site [chemical binding]; other site 525146001401 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525146001402 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 525146001403 TM-ABC transporter signature motif; other site 525146001404 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 525146001405 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 525146001406 TM-ABC transporter signature motif; other site 525146001407 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 525146001408 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 525146001409 Walker A/P-loop; other site 525146001410 ATP binding site [chemical binding]; other site 525146001411 Q-loop/lid; other site 525146001412 ABC transporter signature motif; other site 525146001413 Walker B; other site 525146001414 D-loop; other site 525146001415 H-loop/switch region; other site 525146001416 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 525146001417 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 525146001418 Walker A/P-loop; other site 525146001419 ATP binding site [chemical binding]; other site 525146001420 Q-loop/lid; other site 525146001421 ABC transporter signature motif; other site 525146001422 Walker B; other site 525146001423 D-loop; other site 525146001424 H-loop/switch region; other site 525146001425 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 525146001426 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 525146001427 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 525146001428 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 525146001429 Phosphoglycerate kinase; Region: PGK; pfam00162 525146001430 substrate binding site [chemical binding]; other site 525146001431 hinge regions; other site 525146001432 ADP binding site [chemical binding]; other site 525146001433 catalytic site [active] 525146001434 transketolase; Reviewed; Region: PRK12753 525146001435 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 525146001436 TPP-binding site [chemical binding]; other site 525146001437 dimer interface [polypeptide binding]; other site 525146001438 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 525146001439 PYR/PP interface [polypeptide binding]; other site 525146001440 dimer interface [polypeptide binding]; other site 525146001441 TPP binding site [chemical binding]; other site 525146001442 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 525146001443 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 525146001444 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 525146001445 substrate binding site [chemical binding]; other site 525146001446 hexamer interface [polypeptide binding]; other site 525146001447 metal binding site [ion binding]; metal-binding site 525146001448 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 525146001449 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 525146001450 DNA binding residues [nucleotide binding] 525146001451 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 525146001452 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 525146001453 putative tRNA-binding site [nucleotide binding]; other site 525146001454 B3/4 domain; Region: B3_4; pfam03483 525146001455 tRNA synthetase B5 domain; Region: B5; smart00874 525146001456 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 525146001457 dimer interface [polypeptide binding]; other site 525146001458 motif 1; other site 525146001459 motif 3; other site 525146001460 motif 2; other site 525146001461 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 525146001462 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 525146001463 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 525146001464 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 525146001465 dimer interface [polypeptide binding]; other site 525146001466 motif 1; other site 525146001467 active site 525146001468 motif 2; other site 525146001469 motif 3; other site 525146001470 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 525146001471 23S rRNA binding site [nucleotide binding]; other site 525146001472 L21 binding site [polypeptide binding]; other site 525146001473 L13 binding site [polypeptide binding]; other site 525146001474 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 525146001475 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 525146001476 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 525146001477 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 525146001478 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 525146001479 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 525146001480 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 525146001481 active site 525146001482 dimer interface [polypeptide binding]; other site 525146001483 motif 1; other site 525146001484 motif 2; other site 525146001485 motif 3; other site 525146001486 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 525146001487 anticodon binding site; other site 525146001488 MOSC domain; Region: MOSC; pfam03473 525146001489 Protein of unknown function (DUF554); Region: DUF554; pfam04474 525146001490 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 525146001491 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 525146001492 tetramer interfaces [polypeptide binding]; other site 525146001493 binuclear metal-binding site [ion binding]; other site 525146001494 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 525146001495 rRNA binding site [nucleotide binding]; other site 525146001496 predicted 30S ribosome binding site; other site 525146001497 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 525146001498 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 525146001499 trimer interface [polypeptide binding]; other site 525146001500 dimer interface [polypeptide binding]; other site 525146001501 putative active site [active] 525146001502 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 525146001503 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 525146001504 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 525146001505 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 525146001506 2-isopropylmalate synthase; Validated; Region: PRK00915 525146001507 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 525146001508 active site 525146001509 catalytic residues [active] 525146001510 metal binding site [ion binding]; metal-binding site 525146001511 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 525146001512 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 525146001513 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 525146001514 substrate binding site [chemical binding]; other site 525146001515 ligand binding site [chemical binding]; other site 525146001516 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 525146001517 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 525146001518 substrate binding site [chemical binding]; other site 525146001519 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 525146001520 tartrate dehydrogenase; Region: TTC; TIGR02089 525146001521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525146001522 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525146001523 putative active site [active] 525146001524 heme pocket [chemical binding]; other site 525146001525 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 525146001526 heme pocket [chemical binding]; other site 525146001527 putative active site [active] 525146001528 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525146001529 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146001530 metal binding site [ion binding]; metal-binding site 525146001531 active site 525146001532 I-site; other site 525146001533 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 525146001534 Glucose inhibited division protein A; Region: GIDA; pfam01134 525146001535 Predicted permeases [General function prediction only]; Region: RarD; COG2962 525146001536 EamA-like transporter family; Region: EamA; pfam00892 525146001537 EamA-like transporter family; Region: EamA; pfam00892 525146001538 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 525146001539 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 525146001540 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 525146001541 RIP metalloprotease RseP; Region: TIGR00054 525146001542 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 525146001543 active site 525146001544 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 525146001545 protein binding site [polypeptide binding]; other site 525146001546 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 525146001547 putative substrate binding region [chemical binding]; other site 525146001548 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 525146001549 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 525146001550 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 525146001551 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 525146001552 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 525146001553 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 525146001554 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 525146001555 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 525146001556 catalytic residue [active] 525146001557 putative FPP diphosphate binding site; other site 525146001558 putative FPP binding hydrophobic cleft; other site 525146001559 dimer interface [polypeptide binding]; other site 525146001560 putative IPP diphosphate binding site; other site 525146001561 ribosome recycling factor; Reviewed; Region: frr; PRK00083 525146001562 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 525146001563 hinge region; other site 525146001564 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 525146001565 putative nucleotide binding site [chemical binding]; other site 525146001566 uridine monophosphate binding site [chemical binding]; other site 525146001567 homohexameric interface [polypeptide binding]; other site 525146001568 Predicted membrane protein [Function unknown]; Region: COG4392 525146001569 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 525146001570 HPP family; Region: HPP; pfam04982 525146001571 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 525146001572 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 525146001573 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 525146001574 Flavodoxin domain; Region: Flavodoxin_3; pfam12641 525146001575 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 525146001576 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 525146001577 ligand binding site [chemical binding]; other site 525146001578 flexible hinge region; other site 525146001579 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 525146001580 Flagellar protein FliS; Region: FliS; cl00654 525146001581 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 525146001582 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 525146001583 major facilitator superfamily transporter; Provisional; Region: PRK05122 525146001584 VacJ like lipoprotein; Region: VacJ; cl01073 525146001585 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 525146001586 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 525146001587 mce related protein; Region: MCE; pfam02470 525146001588 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 525146001589 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 525146001590 Walker A/P-loop; other site 525146001591 ATP binding site [chemical binding]; other site 525146001592 Q-loop/lid; other site 525146001593 ABC transporter signature motif; other site 525146001594 Walker B; other site 525146001595 D-loop; other site 525146001596 H-loop/switch region; other site 525146001597 hypothetical protein; Validated; Region: PRK00110 525146001598 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 525146001599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146001600 S-adenosylmethionine binding site [chemical binding]; other site 525146001601 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 525146001602 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 525146001603 active site 525146001604 Cu2+ binding site [ion binding]; other site 525146001605 E-class dimer interface [polypeptide binding]; other site 525146001606 Zn2+ binding site [ion binding]; other site 525146001607 P-class dimer interface [polypeptide binding]; other site 525146001608 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 525146001609 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 525146001610 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 525146001611 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 525146001612 NAD binding site [chemical binding]; other site 525146001613 substrate binding site [chemical binding]; other site 525146001614 homodimer interface [polypeptide binding]; other site 525146001615 active site 525146001616 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 525146001617 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 525146001618 substrate binding site; other site 525146001619 tetramer interface; other site 525146001620 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 525146001621 Domain of unknown function DUF302; Region: DUF302; pfam03625 525146001622 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 525146001623 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 525146001624 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 525146001625 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 525146001626 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 525146001627 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 525146001628 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 525146001629 homodimer interface [polypeptide binding]; other site 525146001630 metal binding site [ion binding]; metal-binding site 525146001631 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 525146001632 homodimer interface [polypeptide binding]; other site 525146001633 active site 525146001634 putative chemical substrate binding site [chemical binding]; other site 525146001635 metal binding site [ion binding]; metal-binding site 525146001636 Colicin V production protein; Region: Colicin_V; pfam02674 525146001637 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525146001638 active site 525146001639 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 525146001640 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 525146001641 putative MPT binding site; other site 525146001642 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 525146001643 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 525146001644 [4Fe-4S] binding site [ion binding]; other site 525146001645 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525146001646 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 525146001647 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 525146001648 molybdopterin cofactor binding site; other site 525146001649 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 525146001650 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 525146001651 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525146001652 heme-binding residues [chemical binding]; other site 525146001653 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 525146001654 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525146001655 acyl-activating enzyme (AAE) consensus motif; other site 525146001656 AMP binding site [chemical binding]; other site 525146001657 active site 525146001658 CoA binding site [chemical binding]; other site 525146001659 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 525146001660 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 525146001661 phosphoglyceromutase; Provisional; Region: PRK05434 525146001662 SprT-like family; Region: SprT-like; pfam10263 525146001663 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 525146001664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146001665 ABC-ATPase subunit interface; other site 525146001666 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 525146001667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146001668 dimer interface [polypeptide binding]; other site 525146001669 conserved gate region; other site 525146001670 putative PBP binding loops; other site 525146001671 ABC-ATPase subunit interface; other site 525146001672 PBP superfamily domain; Region: PBP_like_2; cl17296 525146001673 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 525146001674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146001675 active site 525146001676 phosphorylation site [posttranslational modification] 525146001677 intermolecular recognition site; other site 525146001678 dimerization interface [polypeptide binding]; other site 525146001679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525146001680 DNA binding site [nucleotide binding] 525146001681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525146001682 dimer interface [polypeptide binding]; other site 525146001683 phosphorylation site [posttranslational modification] 525146001684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146001685 ATP binding site [chemical binding]; other site 525146001686 Mg2+ binding site [ion binding]; other site 525146001687 G-X-G motif; other site 525146001688 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 525146001689 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 525146001690 Walker A/P-loop; other site 525146001691 ATP binding site [chemical binding]; other site 525146001692 Q-loop/lid; other site 525146001693 ABC transporter signature motif; other site 525146001694 Walker B; other site 525146001695 D-loop; other site 525146001696 H-loop/switch region; other site 525146001697 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 525146001698 PhoU domain; Region: PhoU; pfam01895 525146001699 PhoU domain; Region: PhoU; pfam01895 525146001700 Flagellin N-methylase; Region: FliB; cl00497 525146001701 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 525146001702 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 525146001703 Walker A/P-loop; other site 525146001704 ATP binding site [chemical binding]; other site 525146001705 Q-loop/lid; other site 525146001706 ABC transporter signature motif; other site 525146001707 Walker B; other site 525146001708 D-loop; other site 525146001709 H-loop/switch region; other site 525146001710 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 525146001711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146001712 dimer interface [polypeptide binding]; other site 525146001713 conserved gate region; other site 525146001714 putative PBP binding loops; other site 525146001715 ABC-ATPase subunit interface; other site 525146001716 NMT1-like family; Region: NMT1_2; pfam13379 525146001717 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 525146001718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146001719 Radical SAM superfamily; Region: Radical_SAM; pfam04055 525146001720 FeS/SAM binding site; other site 525146001721 4Fe-4S binding domain; Region: Fer4_5; pfam12801 525146001722 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 525146001723 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 525146001724 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 525146001725 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 525146001726 Clp amino terminal domain; Region: Clp_N; pfam02861 525146001727 Clp amino terminal domain; Region: Clp_N; pfam02861 525146001728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146001729 Walker A motif; other site 525146001730 ATP binding site [chemical binding]; other site 525146001731 Walker B motif; other site 525146001732 arginine finger; other site 525146001733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146001734 Walker A motif; other site 525146001735 ATP binding site [chemical binding]; other site 525146001736 Walker B motif; other site 525146001737 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 525146001738 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 525146001739 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 525146001740 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 525146001741 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 525146001742 HSP70 interaction site [polypeptide binding]; other site 525146001743 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 525146001744 substrate binding site [polypeptide binding]; other site 525146001745 dimer interface [polypeptide binding]; other site 525146001746 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666 525146001747 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 525146001748 GIY-YIG motif/motif A; other site 525146001749 active site 525146001750 catalytic site [active] 525146001751 putative DNA binding site [nucleotide binding]; other site 525146001752 metal binding site [ion binding]; metal-binding site 525146001753 UvrB/uvrC motif; Region: UVR; pfam02151 525146001754 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 525146001755 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 525146001756 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 525146001757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146001758 catalytic residue [active] 525146001759 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 525146001760 O-Antigen ligase; Region: Wzy_C; pfam04932 525146001761 LabA_like proteins; Region: LabA_like; cd06167 525146001762 putative metal binding site [ion binding]; other site 525146001763 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525146001764 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525146001765 substrate binding pocket [chemical binding]; other site 525146001766 membrane-bound complex binding site; other site 525146001767 hinge residues; other site 525146001768 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525146001769 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525146001770 substrate binding pocket [chemical binding]; other site 525146001771 membrane-bound complex binding site; other site 525146001772 hinge residues; other site 525146001773 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 525146001774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146001775 dimer interface [polypeptide binding]; other site 525146001776 conserved gate region; other site 525146001777 putative PBP binding loops; other site 525146001778 ABC-ATPase subunit interface; other site 525146001779 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525146001780 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 525146001781 Walker A/P-loop; other site 525146001782 ATP binding site [chemical binding]; other site 525146001783 Q-loop/lid; other site 525146001784 ABC transporter signature motif; other site 525146001785 Walker B; other site 525146001786 D-loop; other site 525146001787 H-loop/switch region; other site 525146001788 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 525146001789 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 525146001790 Ligand Binding Site [chemical binding]; other site 525146001791 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 525146001792 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 525146001793 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 525146001794 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 525146001795 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 525146001796 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 525146001797 Yip1 domain; Region: Yip1; pfam04893 525146001798 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 525146001799 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 525146001800 Putative cyclase; Region: Cyclase; pfam04199 525146001801 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 525146001802 MarR family; Region: MarR_2; pfam12802 525146001803 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 525146001804 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 525146001805 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 525146001806 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 525146001807 peroxiredoxin; Region: AhpC; TIGR03137 525146001808 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 525146001809 dimer interface [polypeptide binding]; other site 525146001810 decamer (pentamer of dimers) interface [polypeptide binding]; other site 525146001811 catalytic triad [active] 525146001812 peroxidatic and resolving cysteines [active] 525146001813 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 525146001814 metal binding site 2 [ion binding]; metal-binding site 525146001815 putative DNA binding helix; other site 525146001816 metal binding site 1 [ion binding]; metal-binding site 525146001817 dimer interface [polypeptide binding]; other site 525146001818 structural Zn2+ binding site [ion binding]; other site 525146001819 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 525146001820 active site 525146001821 MltA specific insert domain; Region: MltA; smart00925 525146001822 3D domain; Region: 3D; pfam06725 525146001823 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 525146001824 periplasmic chaperone; Provisional; Region: PRK10780 525146001825 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 525146001826 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 525146001827 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 525146001828 active site 525146001829 metal binding site [ion binding]; metal-binding site 525146001830 This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078 525146001831 TolB amino-terminal domain; Region: TolB_N; pfam04052 525146001832 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 525146001833 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 525146001834 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 525146001835 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 525146001836 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 525146001837 Surface antigen; Region: Bac_surface_Ag; pfam01103 525146001838 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525146001839 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525146001840 Walker A/P-loop; other site 525146001841 ATP binding site [chemical binding]; other site 525146001842 Q-loop/lid; other site 525146001843 ABC transporter signature motif; other site 525146001844 Walker B; other site 525146001845 D-loop; other site 525146001846 H-loop/switch region; other site 525146001847 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 525146001848 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525146001849 FtsX-like permease family; Region: FtsX; pfam02687 525146001850 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 525146001851 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 525146001852 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 525146001853 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 525146001854 [4Fe-4S] binding site [ion binding]; other site 525146001855 molybdopterin cofactor binding site; other site 525146001856 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 525146001857 molybdopterin cofactor binding site; other site 525146001858 NapD protein; Region: NapD; pfam03927 525146001859 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525146001860 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525146001861 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 525146001862 4Fe-4S binding domain; Region: Fer4_5; pfam12801 525146001863 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 525146001864 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 525146001865 dimer interface [polypeptide binding]; other site 525146001866 putative anticodon binding site; other site 525146001867 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 525146001868 motif 1; other site 525146001869 active site 525146001870 motif 2; other site 525146001871 motif 3; other site 525146001872 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 525146001873 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 525146001874 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 525146001875 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 525146001876 hypothetical protein; Provisional; Region: PRK10621 525146001877 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525146001878 Protein of unknown function, DUF486; Region: DUF486; cl01236 525146001879 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 525146001880 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 525146001881 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 525146001882 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 525146001883 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 525146001884 TrkA-N domain; Region: TrkA_N; pfam02254 525146001885 TrkA-C domain; Region: TrkA_C; pfam02080 525146001886 Protein of unknown function DUF45; Region: DUF45; cl00636 525146001887 Rubrerythrin [Energy production and conversion]; Region: COG1592 525146001888 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 525146001889 binuclear metal center [ion binding]; other site 525146001890 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 525146001891 iron binding site [ion binding]; other site 525146001892 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 525146001893 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 525146001894 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 525146001895 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525146001896 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 525146001897 Walker A/P-loop; other site 525146001898 ATP binding site [chemical binding]; other site 525146001899 Q-loop/lid; other site 525146001900 ABC transporter signature motif; other site 525146001901 Walker B; other site 525146001902 D-loop; other site 525146001903 H-loop/switch region; other site 525146001904 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 525146001905 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525146001906 HlyD family secretion protein; Region: HlyD_3; pfam13437 525146001907 PAS fold; Region: PAS_4; pfam08448 525146001908 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525146001909 putative active site [active] 525146001910 heme pocket [chemical binding]; other site 525146001911 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525146001912 Zn2+ binding site [ion binding]; other site 525146001913 Mg2+ binding site [ion binding]; other site 525146001914 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525146001915 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525146001916 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 525146001917 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525146001918 substrate binding pocket [chemical binding]; other site 525146001919 membrane-bound complex binding site; other site 525146001920 hinge residues; other site 525146001921 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525146001922 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525146001923 substrate binding pocket [chemical binding]; other site 525146001924 membrane-bound complex binding site; other site 525146001925 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525146001926 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146001927 metal binding site [ion binding]; metal-binding site 525146001928 active site 525146001929 I-site; other site 525146001930 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 525146001931 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525146001932 non-specific DNA binding site [nucleotide binding]; other site 525146001933 salt bridge; other site 525146001934 sequence-specific DNA binding site [nucleotide binding]; other site 525146001935 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 525146001936 homodimer interface [polypeptide binding]; other site 525146001937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146001938 catalytic residue [active] 525146001939 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 525146001940 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 525146001941 EamA-like transporter family; Region: EamA; pfam00892 525146001942 FeoA domain; Region: FeoA; cl00838 525146001943 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 525146001944 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 525146001945 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 525146001946 G1 box; other site 525146001947 GTP/Mg2+ binding site [chemical binding]; other site 525146001948 Switch I region; other site 525146001949 G2 box; other site 525146001950 G3 box; other site 525146001951 Switch II region; other site 525146001952 G4 box; other site 525146001953 G5 box; other site 525146001954 Nucleoside recognition; Region: Gate; pfam07670 525146001955 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 525146001956 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 525146001957 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 525146001958 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 525146001959 active site 525146001960 hypothetical protein; Provisional; Region: PRK05255 525146001961 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 525146001962 UbiA prenyltransferase family; Region: UbiA; pfam01040 525146001963 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 525146001964 MPT binding site; other site 525146001965 trimer interface [polypeptide binding]; other site 525146001966 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 525146001967 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 525146001968 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 525146001969 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 525146001970 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 525146001971 P loop; other site 525146001972 GTP binding site [chemical binding]; other site 525146001973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146001974 active site 525146001975 phosphorylation site [posttranslational modification] 525146001976 intermolecular recognition site; other site 525146001977 dimerization interface [polypeptide binding]; other site 525146001978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146001979 binding surface 525146001980 TPR motif; other site 525146001981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146001982 binding surface 525146001983 TPR repeat; Region: TPR_11; pfam13414 525146001984 TPR motif; other site 525146001985 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 525146001986 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 525146001987 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 525146001988 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 525146001989 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 525146001990 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 525146001991 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 525146001992 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 525146001993 putative translocon binding site; other site 525146001994 protein-rRNA interface [nucleotide binding]; other site 525146001995 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 525146001996 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 525146001997 G-X-X-G motif; other site 525146001998 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 525146001999 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 525146002000 23S rRNA interface [nucleotide binding]; other site 525146002001 5S rRNA interface [nucleotide binding]; other site 525146002002 putative antibiotic binding site [chemical binding]; other site 525146002003 L25 interface [polypeptide binding]; other site 525146002004 L27 interface [polypeptide binding]; other site 525146002005 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 525146002006 23S rRNA interface [nucleotide binding]; other site 525146002007 putative translocon interaction site; other site 525146002008 signal recognition particle (SRP54) interaction site; other site 525146002009 L23 interface [polypeptide binding]; other site 525146002010 trigger factor interaction site; other site 525146002011 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 525146002012 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 525146002013 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 525146002014 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 525146002015 RNA binding site [nucleotide binding]; other site 525146002016 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 525146002017 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 525146002018 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 525146002019 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 525146002020 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 525146002021 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 525146002022 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 525146002023 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 525146002024 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 525146002025 23S rRNA interface [nucleotide binding]; other site 525146002026 5S rRNA interface [nucleotide binding]; other site 525146002027 L27 interface [polypeptide binding]; other site 525146002028 L5 interface [polypeptide binding]; other site 525146002029 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 525146002030 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 525146002031 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 525146002032 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 525146002033 23S rRNA binding site [nucleotide binding]; other site 525146002034 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 525146002035 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 525146002036 SecY translocase; Region: SecY; pfam00344 525146002037 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 525146002038 active site 525146002039 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 525146002040 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 525146002041 30S ribosomal protein S13; Region: bact_S13; TIGR03631 525146002042 30S ribosomal protein S11; Validated; Region: PRK05309 525146002043 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 525146002044 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 525146002045 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525146002046 RNA binding surface [nucleotide binding]; other site 525146002047 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 525146002048 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 525146002049 alphaNTD homodimer interface [polypeptide binding]; other site 525146002050 alphaNTD - beta interaction site [polypeptide binding]; other site 525146002051 alphaNTD - beta' interaction site [polypeptide binding]; other site 525146002052 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 525146002053 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 525146002054 short chain dehydrogenase; Validated; Region: PRK08264 525146002055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525146002056 NAD(P) binding site [chemical binding]; other site 525146002057 active site 525146002058 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 525146002059 dimerization interface [polypeptide binding]; other site 525146002060 putative ATP binding site [chemical binding]; other site 525146002061 trigger factor; Region: tig; TIGR00115 525146002062 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 525146002063 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 525146002064 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 525146002065 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 525146002066 oligomer interface [polypeptide binding]; other site 525146002067 active site residues [active] 525146002068 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 525146002069 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 525146002070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146002071 Walker A motif; other site 525146002072 ATP binding site [chemical binding]; other site 525146002073 Walker B motif; other site 525146002074 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 525146002075 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 525146002076 Found in ATP-dependent protease La (LON); Region: LON; smart00464 525146002077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146002078 Walker A motif; other site 525146002079 ATP binding site [chemical binding]; other site 525146002080 Walker B motif; other site 525146002081 arginine finger; other site 525146002082 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 525146002083 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 525146002084 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 525146002085 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 525146002086 dimerization interface 3.5A [polypeptide binding]; other site 525146002087 active site 525146002088 Uncharacterized conserved protein [Function unknown]; Region: COG3334 525146002089 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 525146002090 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 525146002091 dimer interface [polypeptide binding]; other site 525146002092 substrate binding site [chemical binding]; other site 525146002093 ATP binding site [chemical binding]; other site 525146002094 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 525146002095 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 525146002096 Domain of unknown function (DUF4417); Region: DUF4417; pfam14386 525146002097 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 525146002098 hypothetical protein; Region: PHA00661 525146002099 hypothetical protein; Provisional; Region: PHA02515 525146002100 hypothetical protein; Region: PHA00662 525146002101 major capsid protein; Region: PHA00665 525146002102 putative protease; Region: PHA00666 525146002103 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 525146002104 hypothetical protein; Region: PHA00670 525146002105 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 525146002106 Terminase-like family; Region: Terminase_6; pfam03237 525146002107 large terminase protein; Provisional; Region: 17; PHA02533 525146002108 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 525146002109 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 525146002110 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 525146002111 Mor transcription activator family; Region: Mor; cl02360 525146002112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525146002113 non-specific DNA binding site [nucleotide binding]; other site 525146002114 Predicted transcriptional regulator [Transcription]; Region: COG2932 525146002115 salt bridge; other site 525146002116 sequence-specific DNA binding site [nucleotide binding]; other site 525146002117 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 525146002118 Catalytic site [active] 525146002119 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 525146002120 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 525146002121 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 525146002122 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525146002123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146002124 active site 525146002125 phosphorylation site [posttranslational modification] 525146002126 intermolecular recognition site; other site 525146002127 dimerization interface [polypeptide binding]; other site 525146002128 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525146002129 DNA binding site [nucleotide binding] 525146002130 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525146002131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525146002132 dimer interface [polypeptide binding]; other site 525146002133 phosphorylation site [posttranslational modification] 525146002134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525146002135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146002136 ATP binding site [chemical binding]; other site 525146002137 Mg2+ binding site [ion binding]; other site 525146002138 G-X-G motif; other site 525146002139 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 525146002140 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525146002141 HlyD family secretion protein; Region: HlyD_3; pfam13437 525146002142 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 525146002143 Protein export membrane protein; Region: SecD_SecF; cl14618 525146002144 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 525146002145 Protein export membrane protein; Region: SecD_SecF; cl14618 525146002146 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 525146002147 MviN-like protein; Region: MVIN; pfam03023 525146002148 ribonuclease R; Region: RNase_R; TIGR02063 525146002149 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 525146002150 RNB domain; Region: RNB; pfam00773 525146002151 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 525146002152 RNA binding site [nucleotide binding]; other site 525146002153 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 525146002154 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 525146002155 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 525146002156 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 525146002157 substrate binding site [chemical binding]; other site 525146002158 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 525146002159 active site 525146002160 putative DNA-binding cleft [nucleotide binding]; other site 525146002161 dimer interface [polypeptide binding]; other site 525146002162 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 525146002163 Permease; Region: Permease; pfam02405 525146002164 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 525146002165 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 525146002166 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 525146002167 active site 525146002168 HIGH motif; other site 525146002169 KMSK motif region; other site 525146002170 tRNA binding surface [nucleotide binding]; other site 525146002171 DALR anticodon binding domain; Region: DALR_1; smart00836 525146002172 anticodon binding site; other site 525146002173 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 525146002174 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 525146002175 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 525146002176 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 525146002177 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 525146002178 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 525146002179 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 525146002180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525146002181 putative DNA binding site [nucleotide binding]; other site 525146002182 putative Zn2+ binding site [ion binding]; other site 525146002183 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 525146002184 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 525146002185 nudix motif; other site 525146002186 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 525146002187 NAD synthetase; Provisional; Region: PRK13981 525146002188 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 525146002189 multimer interface [polypeptide binding]; other site 525146002190 active site 525146002191 catalytic triad [active] 525146002192 protein interface 1 [polypeptide binding]; other site 525146002193 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 525146002194 homodimer interface [polypeptide binding]; other site 525146002195 NAD binding pocket [chemical binding]; other site 525146002196 ATP binding pocket [chemical binding]; other site 525146002197 Mg binding site [ion binding]; other site 525146002198 active-site loop [active] 525146002199 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 525146002200 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 525146002201 putative active site [active] 525146002202 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 525146002203 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 525146002204 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525146002205 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146002206 metal binding site [ion binding]; metal-binding site 525146002207 active site 525146002208 I-site; other site 525146002209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146002210 binding surface 525146002211 TPR motif; other site 525146002212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146002213 binding surface 525146002214 TPR motif; other site 525146002215 cytidylate kinase; Provisional; Region: cmk; PRK00023 525146002216 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 525146002217 CMP-binding site; other site 525146002218 The sites determining sugar specificity; other site 525146002219 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 525146002220 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525146002221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146002222 homodimer interface [polypeptide binding]; other site 525146002223 catalytic residue [active] 525146002224 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525146002225 Ligand Binding Site [chemical binding]; other site 525146002226 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 525146002227 Short C-terminal domain; Region: SHOCT; pfam09851 525146002228 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 525146002229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525146002230 dimer interface [polypeptide binding]; other site 525146002231 phosphorylation site [posttranslational modification] 525146002232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146002233 ATP binding site [chemical binding]; other site 525146002234 G-X-G motif; other site 525146002235 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525146002236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146002237 active site 525146002238 phosphorylation site [posttranslational modification] 525146002239 intermolecular recognition site; other site 525146002240 dimerization interface [polypeptide binding]; other site 525146002241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146002242 Walker A motif; other site 525146002243 ATP binding site [chemical binding]; other site 525146002244 Walker B motif; other site 525146002245 arginine finger; other site 525146002246 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525146002247 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 525146002248 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525146002249 4Fe-4S binding domain; Region: Fer4; pfam00037 525146002250 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 525146002251 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 525146002252 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 525146002253 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 525146002254 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 525146002255 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 525146002256 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 525146002257 hydrogenase 4 subunit B; Validated; Region: PRK06521 525146002258 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 525146002259 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 525146002260 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 525146002261 NAD binding site [chemical binding]; other site 525146002262 putative substrate binding site 2 [chemical binding]; other site 525146002263 putative substrate binding site 1 [chemical binding]; other site 525146002264 active site 525146002265 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 525146002266 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 525146002267 active site 525146002268 PBP superfamily domain; Region: PBP_like_2; cl17296 525146002269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146002270 dimer interface [polypeptide binding]; other site 525146002271 conserved gate region; other site 525146002272 putative PBP binding loops; other site 525146002273 ABC-ATPase subunit interface; other site 525146002274 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 525146002275 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525146002276 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 525146002277 Walker A/P-loop; other site 525146002278 ATP binding site [chemical binding]; other site 525146002279 Q-loop/lid; other site 525146002280 ABC transporter signature motif; other site 525146002281 Walker B; other site 525146002282 D-loop; other site 525146002283 H-loop/switch region; other site 525146002284 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 525146002285 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 525146002286 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 525146002287 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 525146002288 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 525146002289 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 525146002290 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 525146002291 lipoyl attachment site [posttranslational modification]; other site 525146002292 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 525146002293 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 525146002294 tetramer interface [polypeptide binding]; other site 525146002295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146002296 catalytic residue [active] 525146002297 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 525146002298 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525146002299 catalytic residue [active] 525146002300 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 525146002301 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 525146002302 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 525146002303 homodimer interface [polypeptide binding]; other site 525146002304 oligonucleotide binding site [chemical binding]; other site 525146002305 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 525146002306 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 525146002307 active site 525146002308 metal binding site [ion binding]; metal-binding site 525146002309 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 525146002310 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 525146002311 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 525146002312 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525146002313 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 525146002314 putative PBP binding regions; other site 525146002315 ABC-ATPase subunit interface; other site 525146002316 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 525146002317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525146002318 Walker A/P-loop; other site 525146002319 ATP binding site [chemical binding]; other site 525146002320 Q-loop/lid; other site 525146002321 ABC transporter signature motif; other site 525146002322 Walker B; other site 525146002323 D-loop; other site 525146002324 H-loop/switch region; other site 525146002325 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 525146002326 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525146002327 intersubunit interface [polypeptide binding]; other site 525146002328 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 525146002329 active site 525146002330 SAM binding site [chemical binding]; other site 525146002331 homodimer interface [polypeptide binding]; other site 525146002332 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 525146002333 dimerization interface [polypeptide binding]; other site 525146002334 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 525146002335 ATP binding site [chemical binding]; other site 525146002336 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 525146002337 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 525146002338 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 525146002339 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 525146002340 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 525146002341 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 525146002342 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525146002343 catalytic residue [active] 525146002344 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 525146002345 L-aspartate oxidase; Provisional; Region: PRK06175 525146002346 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 525146002347 quinolinate synthetase; Provisional; Region: PRK09375 525146002348 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 525146002349 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 525146002350 dimerization interface [polypeptide binding]; other site 525146002351 active site 525146002352 MgtE intracellular N domain; Region: MgtE_N; smart00924 525146002353 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 525146002354 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 525146002355 Divalent cation transporter; Region: MgtE; pfam01769 525146002356 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 525146002357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146002358 active site 525146002359 phosphorylation site [posttranslational modification] 525146002360 intermolecular recognition site; other site 525146002361 dimerization interface [polypeptide binding]; other site 525146002362 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 525146002363 DNA binding residues [nucleotide binding] 525146002364 dimerization interface [polypeptide binding]; other site 525146002365 Predicted permeases [General function prediction only]; Region: COG0730 525146002366 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525146002367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525146002368 dimer interface [polypeptide binding]; other site 525146002369 phosphorylation site [posttranslational modification] 525146002370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146002371 ATP binding site [chemical binding]; other site 525146002372 Mg2+ binding site [ion binding]; other site 525146002373 G-X-G motif; other site 525146002374 Response regulator receiver domain; Region: Response_reg; pfam00072 525146002375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146002376 active site 525146002377 phosphorylation site [posttranslational modification] 525146002378 intermolecular recognition site; other site 525146002379 dimerization interface [polypeptide binding]; other site 525146002380 Response regulator receiver domain; Region: Response_reg; pfam00072 525146002381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146002382 active site 525146002383 phosphorylation site [posttranslational modification] 525146002384 intermolecular recognition site; other site 525146002385 dimerization interface [polypeptide binding]; other site 525146002386 Response regulator receiver domain; Region: Response_reg; pfam00072 525146002387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146002388 active site 525146002389 phosphorylation site [posttranslational modification] 525146002390 intermolecular recognition site; other site 525146002391 dimerization interface [polypeptide binding]; other site 525146002392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 525146002393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525146002394 dimer interface [polypeptide binding]; other site 525146002395 phosphorylation site [posttranslational modification] 525146002396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146002397 ATP binding site [chemical binding]; other site 525146002398 Mg2+ binding site [ion binding]; other site 525146002399 G-X-G motif; other site 525146002400 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 525146002401 Predicted transcriptional regulator [Transcription]; Region: COG2932 525146002402 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 525146002403 Catalytic site [active] 525146002404 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 525146002405 Cache domain; Region: Cache_1; pfam02743 525146002406 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525146002407 dimerization interface [polypeptide binding]; other site 525146002408 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146002409 dimer interface [polypeptide binding]; other site 525146002410 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 525146002411 putative CheW interface [polypeptide binding]; other site 525146002412 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 525146002413 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 525146002414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146002415 dimer interface [polypeptide binding]; other site 525146002416 conserved gate region; other site 525146002417 putative PBP binding loops; other site 525146002418 ABC-ATPase subunit interface; other site 525146002419 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 525146002420 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 525146002421 Walker A/P-loop; other site 525146002422 ATP binding site [chemical binding]; other site 525146002423 Q-loop/lid; other site 525146002424 ABC transporter signature motif; other site 525146002425 Walker B; other site 525146002426 D-loop; other site 525146002427 H-loop/switch region; other site 525146002428 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 525146002429 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 525146002430 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 525146002431 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525146002432 molybdopterin cofactor binding site; other site 525146002433 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525146002434 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525146002435 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 525146002436 molybdopterin cofactor binding site; other site 525146002437 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 525146002438 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 525146002439 dimer interface [polypeptide binding]; other site 525146002440 putative functional site; other site 525146002441 putative MPT binding site; other site 525146002442 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 525146002443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 525146002444 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 525146002445 DnaA N-terminal domain; Region: DnaA_N; pfam11638 525146002446 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 525146002447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146002448 ATP binding site [chemical binding]; other site 525146002449 Walker A motif; other site 525146002450 Walker B motif; other site 525146002451 arginine finger; other site 525146002452 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 525146002453 DnaA box-binding interface [nucleotide binding]; other site 525146002454 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 525146002455 putative substrate-binding site; other site 525146002456 nickel binding site [ion binding]; other site 525146002457 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 525146002458 hydrogenase 1 large subunit; Provisional; Region: PRK10170 525146002459 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 525146002460 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 525146002461 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 525146002462 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 525146002463 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525146002464 Cysteine-rich domain; Region: CCG; pfam02754 525146002465 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 525146002466 Rrf2 family protein; Region: rrf2_super; TIGR00738 525146002467 Transcriptional regulator; Region: Rrf2; pfam02082 525146002468 Rrf2 family protein; Region: rrf2_super; TIGR00738 525146002469 Transcriptional regulator; Region: Rrf2; pfam02082 525146002470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 525146002471 phosphorylation site [posttranslational modification] 525146002472 intermolecular recognition site; other site 525146002473 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525146002474 Cysteine-rich domain; Region: CCG; pfam02754 525146002475 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 525146002476 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525146002477 heme-binding residues [chemical binding]; other site 525146002478 SEC-C motif; Region: SEC-C; pfam02810 525146002479 hypothetical protein; Provisional; Region: PRK04233 525146002480 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 525146002481 active site 525146002482 dimer interface [polypeptide binding]; other site 525146002483 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 525146002484 dimer interface [polypeptide binding]; other site 525146002485 active site 525146002486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525146002487 dimer interface [polypeptide binding]; other site 525146002488 phosphorylation site [posttranslational modification] 525146002489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146002490 ATP binding site [chemical binding]; other site 525146002491 Mg2+ binding site [ion binding]; other site 525146002492 G-X-G motif; other site 525146002493 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525146002494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146002495 active site 525146002496 phosphorylation site [posttranslational modification] 525146002497 intermolecular recognition site; other site 525146002498 dimerization interface [polypeptide binding]; other site 525146002499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146002500 Walker A motif; other site 525146002501 ATP binding site [chemical binding]; other site 525146002502 Walker B motif; other site 525146002503 arginine finger; other site 525146002504 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 525146002505 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525146002506 DNA-binding site [nucleotide binding]; DNA binding site 525146002507 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 525146002508 FCD domain; Region: FCD; pfam07729 525146002509 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 525146002510 active site 525146002511 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 525146002512 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 525146002513 putative ligand binding site [chemical binding]; other site 525146002514 putative NAD binding site [chemical binding]; other site 525146002515 catalytic site [active] 525146002516 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 525146002517 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 525146002518 ligand binding site [chemical binding]; other site 525146002519 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 525146002520 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 525146002521 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 525146002522 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 525146002523 TonB C terminal; Region: TonB_2; pfam13103 525146002524 Gram-negative bacterial tonB protein; Region: TonB; cl10048 525146002525 TolA protein; Region: tolA_full; TIGR02794 525146002526 TonB C terminal; Region: TonB_2; pfam13103 525146002527 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 525146002528 TolR protein; Region: tolR; TIGR02801 525146002529 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 525146002530 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 525146002531 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 525146002532 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525146002533 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 525146002534 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 525146002535 HflK protein; Region: hflK; TIGR01933 525146002536 HflC protein; Region: hflC; TIGR01932 525146002537 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 525146002538 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 525146002539 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 525146002540 Catalytic site [active] 525146002541 Transglycosylase SLT domain; Region: SLT_2; pfam13406 525146002542 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 525146002543 N-acetyl-D-glucosamine binding site [chemical binding]; other site 525146002544 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 525146002545 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 525146002546 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 525146002547 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525146002548 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 525146002549 EamA-like transporter family; Region: EamA; pfam00892 525146002550 EamA-like transporter family; Region: EamA; pfam00892 525146002551 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 525146002552 UbiA prenyltransferase family; Region: UbiA; pfam01040 525146002553 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 525146002554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525146002555 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 525146002556 NAD(P) binding site [chemical binding]; other site 525146002557 active site 525146002558 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 525146002559 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 525146002560 substrate binding site; other site 525146002561 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 525146002562 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 525146002563 HflX GTPase family; Region: HflX; cd01878 525146002564 G1 box; other site 525146002565 GTP/Mg2+ binding site [chemical binding]; other site 525146002566 Switch I region; other site 525146002567 G2 box; other site 525146002568 G3 box; other site 525146002569 Switch II region; other site 525146002570 G4 box; other site 525146002571 G5 box; other site 525146002572 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 525146002573 purine monophosphate binding site [chemical binding]; other site 525146002574 dimer interface [polypeptide binding]; other site 525146002575 putative catalytic residues [active] 525146002576 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 525146002577 putative catalytic site [active] 525146002578 putative metal binding site [ion binding]; other site 525146002579 putative phosphate binding site [ion binding]; other site 525146002580 FAD binding domain; Region: FAD_binding_4; pfam01565 525146002581 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 525146002582 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525146002583 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525146002584 Cysteine-rich domain; Region: CCG; pfam02754 525146002585 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525146002586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146002587 binding surface 525146002588 TPR motif; other site 525146002589 TPR repeat; Region: TPR_11; pfam13414 525146002590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146002591 TPR repeat; Region: TPR_11; pfam13414 525146002592 binding surface 525146002593 TPR motif; other site 525146002594 Flagellin N-methylase; Region: FliB; pfam03692 525146002595 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 525146002596 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 525146002597 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 525146002598 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 525146002599 protein binding site [polypeptide binding]; other site 525146002600 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 525146002601 protein binding site [polypeptide binding]; other site 525146002602 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 525146002603 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 525146002604 active site pocket [active] 525146002605 putative dimer interface [polypeptide binding]; other site 525146002606 putative cataytic base [active] 525146002607 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 525146002608 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525146002609 Walker A/P-loop; other site 525146002610 ATP binding site [chemical binding]; other site 525146002611 Q-loop/lid; other site 525146002612 ABC transporter signature motif; other site 525146002613 Walker B; other site 525146002614 D-loop; other site 525146002615 H-loop/switch region; other site 525146002616 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 525146002617 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 525146002618 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 525146002619 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 525146002620 active site 525146002621 multimer interface [polypeptide binding]; other site 525146002622 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 525146002623 NodB motif; other site 525146002624 putative active site [active] 525146002625 putative catalytic site [active] 525146002626 Zn binding site [ion binding]; other site 525146002627 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 525146002628 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 525146002629 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 525146002630 protein binding site [polypeptide binding]; other site 525146002631 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 525146002632 Catalytic dyad [active] 525146002633 Rubrerythrin [Energy production and conversion]; Region: COG1592 525146002634 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 525146002635 binuclear metal center [ion binding]; other site 525146002636 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 525146002637 iron binding site [ion binding]; other site 525146002638 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 525146002639 hypothetical protein; Provisional; Region: PRK11568 525146002640 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 525146002641 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 525146002642 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 525146002643 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525146002644 HlyD family secretion protein; Region: HlyD_3; pfam13437 525146002645 arginine decarboxylase; Provisional; Region: PRK05354 525146002646 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 525146002647 dimer interface [polypeptide binding]; other site 525146002648 active site 525146002649 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525146002650 catalytic residues [active] 525146002651 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 525146002652 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 525146002653 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 525146002654 CPxP motif; other site 525146002655 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 525146002656 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 525146002657 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525146002658 active site 525146002659 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 525146002660 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 525146002661 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 525146002662 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525146002663 ATP binding site [chemical binding]; other site 525146002664 putative Mg++ binding site [ion binding]; other site 525146002665 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525146002666 nucleotide binding region [chemical binding]; other site 525146002667 ATP-binding site [chemical binding]; other site 525146002668 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 525146002669 SurA N-terminal domain; Region: SurA_N_3; cl07813 525146002670 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 525146002671 SurA N-terminal domain; Region: SurA_N; pfam09312 525146002672 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 525146002673 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 525146002674 Helix-turn-helix domain; Region: HTH_25; pfam13413 525146002675 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 525146002676 Recombination protein O N terminal; Region: RecO_N; pfam11967 525146002677 Recombination protein O C terminal; Region: RecO_C; pfam02565 525146002678 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 525146002679 dimer interface [polypeptide binding]; other site 525146002680 motif 1; other site 525146002681 active site 525146002682 motif 2; other site 525146002683 motif 3; other site 525146002684 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 525146002685 DALR anticodon binding domain; Region: DALR_1; pfam05746 525146002686 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 525146002687 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 525146002688 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 525146002689 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 525146002690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146002691 Walker A motif; other site 525146002692 ATP binding site [chemical binding]; other site 525146002693 Walker B motif; other site 525146002694 arginine finger; other site 525146002695 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525146002696 Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679 525146002697 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 525146002698 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 525146002699 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 525146002700 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 525146002701 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 525146002702 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 525146002703 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 525146002704 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 525146002705 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 525146002706 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 525146002707 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 525146002708 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 525146002709 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 525146002710 putative ssRNA endonuclease; Provisional; Region: PRK11558 525146002711 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 525146002712 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525146002713 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 525146002714 Ligand Binding Site [chemical binding]; other site 525146002715 formate transporter FocA; Region: formate_focA; TIGR04060 525146002716 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 525146002717 Predicted kinase [General function prediction only]; Region: COG0645 525146002718 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 525146002719 active site 525146002720 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525146002721 Putative pyruvate format-lyase activating enzyme (DUF1786); Region: DUF1786; cl01638 525146002722 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 525146002723 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525146002724 acyl-activating enzyme (AAE) consensus motif; other site 525146002725 AMP binding site [chemical binding]; other site 525146002726 active site 525146002727 CoA binding site [chemical binding]; other site 525146002728 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 525146002729 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 525146002730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525146002731 dimerization interface [polypeptide binding]; other site 525146002732 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146002733 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146002734 dimer interface [polypeptide binding]; other site 525146002735 putative CheW interface [polypeptide binding]; other site 525146002736 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 525146002737 DNA-binding interface [nucleotide binding]; DNA binding site 525146002738 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 525146002739 HTH-like domain; Region: HTH_21; pfam13276 525146002740 Integrase core domain; Region: rve; pfam00665 525146002741 Integrase core domain; Region: rve_3; pfam13683 525146002742 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525146002743 dimerization interface [polypeptide binding]; other site 525146002744 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146002745 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146002746 dimer interface [polypeptide binding]; other site 525146002747 putative CheW interface [polypeptide binding]; other site 525146002748 GTP-binding protein YchF; Reviewed; Region: PRK09601 525146002749 YchF GTPase; Region: YchF; cd01900 525146002750 G1 box; other site 525146002751 GTP/Mg2+ binding site [chemical binding]; other site 525146002752 Switch I region; other site 525146002753 G2 box; other site 525146002754 Switch II region; other site 525146002755 G3 box; other site 525146002756 G4 box; other site 525146002757 G5 box; other site 525146002758 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 525146002759 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 525146002760 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 525146002761 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 525146002762 prolyl-tRNA synthetase; Provisional; Region: PRK09194 525146002763 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 525146002764 dimer interface [polypeptide binding]; other site 525146002765 motif 1; other site 525146002766 active site 525146002767 motif 2; other site 525146002768 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 525146002769 putative deacylase active site [active] 525146002770 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 525146002771 active site 525146002772 motif 3; other site 525146002773 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 525146002774 anticodon binding site; other site 525146002775 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 525146002776 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 525146002777 generic binding surface II; other site 525146002778 generic binding surface I; other site 525146002779 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 525146002780 Peptidase family M23; Region: Peptidase_M23; pfam01551 525146002781 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 525146002782 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 525146002783 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 525146002784 substrate binding pocket [chemical binding]; other site 525146002785 chain length determination region; other site 525146002786 substrate-Mg2+ binding site; other site 525146002787 catalytic residues [active] 525146002788 aspartate-rich region 1; other site 525146002789 active site lid residues [active] 525146002790 aspartate-rich region 2; other site 525146002791 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 525146002792 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 525146002793 TPP-binding site; other site 525146002794 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 525146002795 PYR/PP interface [polypeptide binding]; other site 525146002796 dimer interface [polypeptide binding]; other site 525146002797 TPP binding site [chemical binding]; other site 525146002798 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 525146002799 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 525146002800 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 525146002801 Ligand Binding Site [chemical binding]; other site 525146002802 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 525146002803 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 525146002804 tRNA; other site 525146002805 putative tRNA binding site [nucleotide binding]; other site 525146002806 putative NADP binding site [chemical binding]; other site 525146002807 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 525146002808 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 525146002809 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 525146002810 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 525146002811 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 525146002812 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525146002813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 525146002814 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 525146002815 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 525146002816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146002817 binding surface 525146002818 TPR motif; other site 525146002819 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 525146002820 DNA protecting protein DprA; Region: dprA; TIGR00732 525146002821 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 525146002822 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525146002823 active site 525146002824 DNA binding site [nucleotide binding] 525146002825 Int/Topo IB signature motif; other site 525146002826 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 525146002827 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 525146002828 DHHA2 domain; Region: DHHA2; pfam02833 525146002829 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 525146002830 active site 525146002831 phosphorylation site [posttranslational modification] 525146002832 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 525146002833 active pocket/dimerization site; other site 525146002834 active site 525146002835 phosphorylation site [posttranslational modification] 525146002836 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 525146002837 AAA domain; Region: AAA_18; pfam13238 525146002838 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 525146002839 30S subunit binding site; other site 525146002840 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 525146002841 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 525146002842 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 525146002843 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 525146002844 CTP synthetase; Validated; Region: pyrG; PRK05380 525146002845 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 525146002846 Catalytic site [active] 525146002847 active site 525146002848 UTP binding site [chemical binding]; other site 525146002849 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 525146002850 active site 525146002851 putative oxyanion hole; other site 525146002852 catalytic triad [active] 525146002853 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 525146002854 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 525146002855 conserved cys residue [active] 525146002856 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 525146002857 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 525146002858 FMN binding site [chemical binding]; other site 525146002859 substrate binding site [chemical binding]; other site 525146002860 putative catalytic residue [active] 525146002861 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 525146002862 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 525146002863 Family description; Region: UvrD_C_2; pfam13538 525146002864 EamA-like transporter family; Region: EamA; pfam00892 525146002865 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 525146002866 EamA-like transporter family; Region: EamA; pfam00892 525146002867 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 525146002868 tetramerization interface [polypeptide binding]; other site 525146002869 active site 525146002870 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 525146002871 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 525146002872 HSP70 interaction site [polypeptide binding]; other site 525146002873 Flagellin N-methylase; Region: FliB; pfam03692 525146002874 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 525146002875 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 525146002876 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 525146002877 TrkA-N domain; Region: TrkA_N; pfam02254 525146002878 TrkA-C domain; Region: TrkA_C; pfam02080 525146002879 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 525146002880 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 525146002881 Walker A/P-loop; other site 525146002882 ATP binding site [chemical binding]; other site 525146002883 Q-loop/lid; other site 525146002884 ABC transporter signature motif; other site 525146002885 Walker B; other site 525146002886 D-loop; other site 525146002887 H-loop/switch region; other site 525146002888 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 525146002889 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525146002890 ABC-ATPase subunit interface; other site 525146002891 dimer interface [polypeptide binding]; other site 525146002892 putative PBP binding regions; other site 525146002893 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525146002894 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 525146002895 intersubunit interface [polypeptide binding]; other site 525146002896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146002897 S-adenosylmethionine binding site [chemical binding]; other site 525146002898 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 525146002899 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 525146002900 N-terminal plug; other site 525146002901 ligand-binding site [chemical binding]; other site 525146002902 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 525146002903 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 525146002904 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 525146002905 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 525146002906 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 525146002907 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525146002908 active site 525146002909 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 525146002910 chaperone protein DnaJ; Provisional; Region: PRK14294 525146002911 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 525146002912 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525146002913 HlyD family secretion protein; Region: HlyD_3; pfam13437 525146002914 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 525146002915 YcaO-like family; Region: YcaO; pfam02624 525146002916 Tetratricopeptide repeat; Region: TPR_16; pfam13432 525146002917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 525146002918 TPR motif; other site 525146002919 binding surface 525146002920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146002921 binding surface 525146002922 TPR motif; other site 525146002923 TPR repeat; Region: TPR_11; pfam13414 525146002924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146002925 S-adenosylmethionine binding site [chemical binding]; other site 525146002926 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 525146002927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146002928 S-adenosylmethionine binding site [chemical binding]; other site 525146002929 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 525146002930 Peptidase family M23; Region: Peptidase_M23; pfam01551 525146002931 Pirin-related protein [General function prediction only]; Region: COG1741 525146002932 Pirin; Region: Pirin; pfam02678 525146002933 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 525146002934 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525146002935 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 525146002936 intersubunit interface [polypeptide binding]; other site 525146002937 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 525146002938 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 525146002939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525146002940 Walker A/P-loop; other site 525146002941 ATP binding site [chemical binding]; other site 525146002942 Q-loop/lid; other site 525146002943 ABC transporter signature motif; other site 525146002944 Walker B; other site 525146002945 D-loop; other site 525146002946 H-loop/switch region; other site 525146002947 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 525146002948 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525146002949 ABC-ATPase subunit interface; other site 525146002950 dimer interface [polypeptide binding]; other site 525146002951 putative PBP binding regions; other site 525146002952 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 525146002953 dimer interface [polypeptide binding]; other site 525146002954 catalytic triad [active] 525146002955 peroxidatic and resolving cysteines [active] 525146002956 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 525146002957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146002958 Walker A motif; other site 525146002959 ATP binding site [chemical binding]; other site 525146002960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146002961 Walker B motif; other site 525146002962 arginine finger; other site 525146002963 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 525146002964 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 525146002965 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525146002966 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 525146002967 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525146002968 active site 525146002969 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 525146002970 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 525146002971 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 525146002972 Methyltransferase domain; Region: Methyltransf_23; pfam13489 525146002973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146002974 S-adenosylmethionine binding site [chemical binding]; other site 525146002975 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 525146002976 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 525146002977 active site 525146002978 homodimer interface [polypeptide binding]; other site 525146002979 LicD family; Region: LicD; pfam04991 525146002980 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 525146002981 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 525146002982 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525146002983 active site 525146002984 Methyltransferase domain; Region: Methyltransf_23; pfam13489 525146002985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146002986 S-adenosylmethionine binding site [chemical binding]; other site 525146002987 aspartate racemase; Region: asp_race; TIGR00035 525146002988 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 525146002989 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 525146002990 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 525146002991 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 525146002992 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 525146002993 putative CheA interaction surface; other site 525146002994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525146002995 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 525146002996 Coenzyme A binding pocket [chemical binding]; other site 525146002997 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 525146002998 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146002999 FeS/SAM binding site; other site 525146003000 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 525146003001 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 525146003002 ribonuclease III; Reviewed; Region: rnc; PRK00102 525146003003 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 525146003004 dimerization interface [polypeptide binding]; other site 525146003005 active site 525146003006 metal binding site [ion binding]; metal-binding site 525146003007 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 525146003008 dsRNA binding site [nucleotide binding]; other site 525146003009 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 525146003010 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 525146003011 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 525146003012 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 525146003013 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525146003014 Walker A/P-loop; other site 525146003015 ATP binding site [chemical binding]; other site 525146003016 Q-loop/lid; other site 525146003017 ABC transporter signature motif; other site 525146003018 Walker B; other site 525146003019 D-loop; other site 525146003020 H-loop/switch region; other site 525146003021 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525146003022 Walker A/P-loop; other site 525146003023 ATP binding site [chemical binding]; other site 525146003024 Q-loop/lid; other site 525146003025 ABC transporter signature motif; other site 525146003026 Walker B; other site 525146003027 D-loop; other site 525146003028 H-loop/switch region; other site 525146003029 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 525146003030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146003031 dimer interface [polypeptide binding]; other site 525146003032 conserved gate region; other site 525146003033 putative PBP binding loops; other site 525146003034 ABC-ATPase subunit interface; other site 525146003035 nickel transporter permease NikB; Provisional; Region: PRK10352 525146003036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146003037 dimer interface [polypeptide binding]; other site 525146003038 conserved gate region; other site 525146003039 putative PBP binding loops; other site 525146003040 ABC-ATPase subunit interface; other site 525146003041 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 525146003042 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 525146003043 substrate binding site [chemical binding]; other site 525146003044 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 525146003045 Protein of unknown function (DUF523); Region: DUF523; pfam04463 525146003046 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 525146003047 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 525146003048 putative substrate-binding site; other site 525146003049 nickel binding site [ion binding]; other site 525146003050 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 525146003051 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 525146003052 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 525146003053 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 525146003054 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 525146003055 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 525146003056 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 525146003057 homodimer interface [polypeptide binding]; other site 525146003058 substrate-cofactor binding pocket; other site 525146003059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146003060 catalytic residue [active] 525146003061 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 525146003062 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 525146003063 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 525146003064 Domain of unknown function DUF20; Region: UPF0118; pfam01594 525146003065 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 525146003066 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 525146003067 Probable Catalytic site; other site 525146003068 metal-binding site 525146003069 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525146003070 active site 525146003071 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 525146003072 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 525146003073 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 525146003074 Predicted integral membrane protein [Function unknown]; Region: COG0392 525146003075 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 525146003076 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 525146003077 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 525146003078 NAD binding site [chemical binding]; other site 525146003079 homotetramer interface [polypeptide binding]; other site 525146003080 homodimer interface [polypeptide binding]; other site 525146003081 substrate binding site [chemical binding]; other site 525146003082 active site 525146003083 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 525146003084 ATP binding site [chemical binding]; other site 525146003085 active site 525146003086 substrate binding site [chemical binding]; other site 525146003087 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 525146003088 histidinol dehydrogenase; Region: hisD; TIGR00069 525146003089 NAD binding site [chemical binding]; other site 525146003090 dimerization interface [polypeptide binding]; other site 525146003091 product binding site; other site 525146003092 substrate binding site [chemical binding]; other site 525146003093 zinc binding site [ion binding]; other site 525146003094 catalytic residues [active] 525146003095 GrpE; Region: GrpE; pfam01025 525146003096 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 525146003097 dimer interface [polypeptide binding]; other site 525146003098 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 525146003099 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 525146003100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146003101 active site 525146003102 phosphorylation site [posttranslational modification] 525146003103 intermolecular recognition site; other site 525146003104 dimerization interface [polypeptide binding]; other site 525146003105 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525146003106 Zn2+ binding site [ion binding]; other site 525146003107 Mg2+ binding site [ion binding]; other site 525146003108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 525146003109 Protein of unknown function (DUF330); Region: DUF330; pfam03886 525146003110 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 525146003111 mce related protein; Region: MCE; pfam02470 525146003112 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525146003113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525146003114 Walker A/P-loop; other site 525146003115 ATP binding site [chemical binding]; other site 525146003116 Q-loop/lid; other site 525146003117 ABC transporter signature motif; other site 525146003118 Walker B; other site 525146003119 D-loop; other site 525146003120 H-loop/switch region; other site 525146003121 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 525146003122 Permease; Region: Permease; pfam02405 525146003123 DNA polymerase I; Region: pola; TIGR00593 525146003124 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 525146003125 active site 525146003126 metal binding site 1 [ion binding]; metal-binding site 525146003127 putative 5' ssDNA interaction site; other site 525146003128 metal binding site 3; metal-binding site 525146003129 metal binding site 2 [ion binding]; metal-binding site 525146003130 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 525146003131 putative DNA binding site [nucleotide binding]; other site 525146003132 putative metal binding site [ion binding]; other site 525146003133 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 525146003134 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 525146003135 active site 525146003136 DNA binding site [nucleotide binding] 525146003137 catalytic site [active] 525146003138 HD domain; Region: HD_3; pfam13023 525146003139 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 525146003140 23S rRNA interface [nucleotide binding]; other site 525146003141 L3 interface [polypeptide binding]; other site 525146003142 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 525146003143 YcaO-like family; Region: YcaO; pfam02624 525146003144 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 525146003145 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 525146003146 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 525146003147 putative ligand binding site [chemical binding]; other site 525146003148 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525146003149 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 525146003150 TM-ABC transporter signature motif; other site 525146003151 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 525146003152 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 525146003153 TM-ABC transporter signature motif; other site 525146003154 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 525146003155 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 525146003156 Walker A/P-loop; other site 525146003157 ATP binding site [chemical binding]; other site 525146003158 Q-loop/lid; other site 525146003159 ABC transporter signature motif; other site 525146003160 Walker B; other site 525146003161 D-loop; other site 525146003162 H-loop/switch region; other site 525146003163 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 525146003164 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 525146003165 Walker A/P-loop; other site 525146003166 ATP binding site [chemical binding]; other site 525146003167 Q-loop/lid; other site 525146003168 ABC transporter signature motif; other site 525146003169 Walker B; other site 525146003170 D-loop; other site 525146003171 H-loop/switch region; other site 525146003172 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 525146003173 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 525146003174 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 525146003175 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 525146003176 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 525146003177 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 525146003178 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146003179 FeS/SAM binding site; other site 525146003180 Hemerythrin; Region: Hemerythrin; cd12107 525146003181 Fe binding site [ion binding]; other site 525146003182 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 525146003183 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 525146003184 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525146003185 catalytic residue [active] 525146003186 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 525146003187 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 525146003188 trimerization site [polypeptide binding]; other site 525146003189 active site 525146003190 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 525146003191 NifU-like domain; Region: NifU; cl00484 525146003192 Transcriptional regulator; Region: Rrf2; cl17282 525146003193 Rrf2 family protein; Region: rrf2_super; TIGR00738 525146003194 Homoserine O-succinyltransferase; Region: HTS; pfam04204 525146003195 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 525146003196 proposed active site lysine [active] 525146003197 conserved cys residue [active] 525146003198 4Fe-4S binding domain; Region: Fer4_6; pfam12837 525146003199 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525146003200 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 525146003201 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525146003202 motif II; other site 525146003203 ornithine carbamoyltransferase; Region: orni_carb_tr; TIGR00658 525146003204 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 525146003205 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 525146003206 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 525146003207 Ligand Binding Site [chemical binding]; other site 525146003208 Staphylococcal nuclease homologues; Region: SNc; smart00318 525146003209 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 525146003210 Catalytic site; other site 525146003211 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 525146003212 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 525146003213 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 525146003214 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 525146003215 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 525146003216 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 525146003217 DNA binding residues [nucleotide binding] 525146003218 DNA primase, catalytic core; Region: dnaG; TIGR01391 525146003219 CHC2 zinc finger; Region: zf-CHC2; cl17510 525146003220 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 525146003221 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 525146003222 active site 525146003223 metal binding site [ion binding]; metal-binding site 525146003224 interdomain interaction site; other site 525146003225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525146003226 Walker A/P-loop; other site 525146003227 ATP binding site [chemical binding]; other site 525146003228 Q-loop/lid; other site 525146003229 ABC transporter signature motif; other site 525146003230 Walker B; other site 525146003231 D-loop; other site 525146003232 H-loop/switch region; other site 525146003233 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 525146003234 Smr domain; Region: Smr; pfam01713 525146003235 Yqey-like protein; Region: YqeY; pfam09424 525146003236 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 525146003237 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 525146003238 IHF dimer interface [polypeptide binding]; other site 525146003239 IHF - DNA interface [nucleotide binding]; other site 525146003240 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 525146003241 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 525146003242 S-adenosylmethionine binding site [chemical binding]; other site 525146003243 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 525146003244 elongation factor G; Reviewed; Region: PRK12740 525146003245 G1 box; other site 525146003246 putative GEF interaction site [polypeptide binding]; other site 525146003247 GTP/Mg2+ binding site [chemical binding]; other site 525146003248 Switch I region; other site 525146003249 G2 box; other site 525146003250 G3 box; other site 525146003251 Switch II region; other site 525146003252 G4 box; other site 525146003253 G5 box; other site 525146003254 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 525146003255 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 525146003256 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 525146003257 argininosuccinate lyase; Provisional; Region: PRK00855 525146003258 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 525146003259 active sites [active] 525146003260 tetramer interface [polypeptide binding]; other site 525146003261 argininosuccinate synthase; Provisional; Region: PRK13820 525146003262 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 525146003263 ANP binding site [chemical binding]; other site 525146003264 Substrate Binding Site II [chemical binding]; other site 525146003265 Substrate Binding Site I [chemical binding]; other site 525146003266 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 525146003267 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 525146003268 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525146003269 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 525146003270 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 525146003271 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525146003272 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 525146003273 IMP binding site; other site 525146003274 dimer interface [polypeptide binding]; other site 525146003275 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 525146003276 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 525146003277 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 525146003278 catalytic site [active] 525146003279 subunit interface [polypeptide binding]; other site 525146003280 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 525146003281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525146003282 Zn2+ binding site [ion binding]; other site 525146003283 Mg2+ binding site [ion binding]; other site 525146003284 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 525146003285 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 525146003286 domain interfaces; other site 525146003287 active site 525146003288 cell division protein MraZ; Reviewed; Region: PRK00326 525146003289 MraZ protein; Region: MraZ; pfam02381 525146003290 MraZ protein; Region: MraZ; pfam02381 525146003291 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 525146003292 MraW methylase family; Region: Methyltransf_5; cl17771 525146003293 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 525146003294 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 525146003295 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 525146003296 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 525146003297 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 525146003298 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525146003299 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525146003300 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525146003301 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525146003302 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 525146003303 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525146003304 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525146003305 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 525146003306 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 525146003307 Mg++ binding site [ion binding]; other site 525146003308 putative catalytic motif [active] 525146003309 putative substrate binding site [chemical binding]; other site 525146003310 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 525146003311 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 525146003312 cell division protein FtsW; Region: ftsW; TIGR02614 525146003313 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 525146003314 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 525146003315 active site 525146003316 homodimer interface [polypeptide binding]; other site 525146003317 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 525146003318 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 525146003319 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 525146003320 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 525146003321 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 525146003322 FAD binding domain; Region: FAD_binding_4; pfam01565 525146003323 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 525146003324 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 525146003325 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 525146003326 cell division protein FtsA; Region: ftsA; TIGR01174 525146003327 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 525146003328 nucleotide binding site [chemical binding]; other site 525146003329 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 525146003330 Cell division protein FtsA; Region: FtsA; pfam14450 525146003331 cell division protein FtsZ; Validated; Region: PRK09330 525146003332 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 525146003333 nucleotide binding site [chemical binding]; other site 525146003334 SulA interaction site; other site 525146003335 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 525146003336 ACT domain-containing protein [General function prediction only]; Region: COG4747 525146003337 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 525146003338 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 525146003339 twin arginine translocase protein A; Provisional; Region: tatA; PRK14859 525146003340 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146003341 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146003342 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 525146003343 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146003344 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146003345 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146003346 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146003347 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146003348 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146003349 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146003350 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146003351 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146003352 VCBS repeat; Region: VCBS_repeat; TIGR01965 525146003353 chromosome condensation membrane protein; Provisional; Region: PRK14196 525146003354 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 525146003355 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 525146003356 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 525146003357 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 525146003358 NADP binding site [chemical binding]; other site 525146003359 active site 525146003360 putative substrate binding site [chemical binding]; other site 525146003361 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 525146003362 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 525146003363 active site 525146003364 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 525146003365 active site 525146003366 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 525146003367 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 525146003368 putative active site [active] 525146003369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 525146003370 Methyltransferase domain; Region: Methyltransf_11; pfam08241 525146003371 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 525146003372 homotrimer interaction site [polypeptide binding]; other site 525146003373 putative active site [active] 525146003374 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 525146003375 aromatic amino acid transport protein; Region: araaP; TIGR00837 525146003376 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 525146003377 Sodium Bile acid symporter family; Region: SBF; pfam01758 525146003378 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 525146003379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525146003380 Walker A/P-loop; other site 525146003381 ATP binding site [chemical binding]; other site 525146003382 Q-loop/lid; other site 525146003383 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525146003384 ABC transporter signature motif; other site 525146003385 Walker B; other site 525146003386 D-loop; other site 525146003387 ABC transporter; Region: ABC_tran_2; pfam12848 525146003388 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525146003389 conserved hypothetical protein; Region: TIGR02231 525146003390 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 525146003391 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 525146003392 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525146003393 motif II; other site 525146003394 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 525146003395 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 525146003396 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525146003397 Zn2+ binding site [ion binding]; other site 525146003398 Mg2+ binding site [ion binding]; other site 525146003399 aspartate kinase; Reviewed; Region: PRK06635 525146003400 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 525146003401 putative catalytic residues [active] 525146003402 putative nucleotide binding site [chemical binding]; other site 525146003403 putative aspartate binding site [chemical binding]; other site 525146003404 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 525146003405 putative allosteric regulatory site; other site 525146003406 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 525146003407 putative allosteric regulatory residue; other site 525146003408 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 525146003409 putative carbohydrate kinase; Provisional; Region: PRK10565 525146003410 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 525146003411 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 525146003412 putative substrate binding site [chemical binding]; other site 525146003413 putative ATP binding site [chemical binding]; other site 525146003414 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14657 525146003415 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 525146003416 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 525146003417 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 525146003418 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 525146003419 Nif-specific regulatory protein; Region: nifA; TIGR01817 525146003420 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 525146003421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146003422 Walker A motif; other site 525146003423 ATP binding site [chemical binding]; other site 525146003424 Walker B motif; other site 525146003425 arginine finger; other site 525146003426 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525146003427 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 525146003428 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 525146003429 Nitrogen regulatory protein P-II; Region: P-II; smart00938 525146003430 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 525146003431 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 525146003432 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 525146003433 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 525146003434 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 525146003435 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 525146003436 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 525146003437 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525146003438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146003439 homodimer interface [polypeptide binding]; other site 525146003440 catalytic residue [active] 525146003441 glutamate dehydrogenase; Provisional; Region: PRK09414 525146003442 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 525146003443 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 525146003444 NAD(P) binding site [chemical binding]; other site 525146003445 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 525146003446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525146003447 PAS domain; Region: PAS_9; pfam13426 525146003448 putative active site [active] 525146003449 heme pocket [chemical binding]; other site 525146003450 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525146003451 Zn2+ binding site [ion binding]; other site 525146003452 Mg2+ binding site [ion binding]; other site 525146003453 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 525146003454 active site 525146003455 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525146003456 4Fe-4S binding domain; Region: Fer4; pfam00037 525146003457 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 525146003458 phosphate binding site [ion binding]; other site 525146003459 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 525146003460 domain_subunit interface; other site 525146003461 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525146003462 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 525146003463 putative FMN binding site [chemical binding]; other site 525146003464 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 525146003465 endonuclease III; Region: ENDO3c; smart00478 525146003466 minor groove reading motif; other site 525146003467 helix-hairpin-helix signature motif; other site 525146003468 substrate binding pocket [chemical binding]; other site 525146003469 active site 525146003470 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 525146003471 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 525146003472 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 525146003473 DNA binding site [nucleotide binding] 525146003474 active site 525146003475 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 525146003476 Helix-turn-helix domain; Region: HTH_18; pfam12833 525146003477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525146003478 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 525146003479 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 525146003480 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525146003481 DNA-binding site [nucleotide binding]; DNA binding site 525146003482 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525146003483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146003484 homodimer interface [polypeptide binding]; other site 525146003485 catalytic residue [active] 525146003486 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 525146003487 Cupin domain; Region: Cupin_2; cl17218 525146003488 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 525146003489 Uncharacterized conserved protein [Function unknown]; Region: COG2461 525146003490 Family of unknown function (DUF438); Region: DUF438; pfam04282 525146003491 Hemerythrin-like domain; Region: Hr-like; cd12108 525146003492 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 525146003493 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 525146003494 putative acyl-acceptor binding pocket; other site 525146003495 recombination factor protein RarA; Reviewed; Region: PRK13342 525146003496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146003497 Walker A motif; other site 525146003498 ATP binding site [chemical binding]; other site 525146003499 Walker B motif; other site 525146003500 arginine finger; other site 525146003501 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 525146003502 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 525146003503 RNA methyltransferase, RsmE family; Region: TIGR00046 525146003504 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 525146003505 GAF domain; Region: GAF; pfam01590 525146003506 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 525146003507 GAF domain; Region: GAF; pfam01590 525146003508 rod shape-determining protein MreB; Provisional; Region: PRK13930 525146003509 MreB and similar proteins; Region: MreB_like; cd10225 525146003510 nucleotide binding site [chemical binding]; other site 525146003511 Mg binding site [ion binding]; other site 525146003512 putative protofilament interaction site [polypeptide binding]; other site 525146003513 RodZ interaction site [polypeptide binding]; other site 525146003514 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 525146003515 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 525146003516 active site 525146003517 dimerization interface [polypeptide binding]; other site 525146003518 Type III pantothenate kinase; Region: Pan_kinase; cl17198 525146003519 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 525146003520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525146003521 Coenzyme A binding pocket [chemical binding]; other site 525146003522 triosephosphate isomerase; Provisional; Region: PRK14565 525146003523 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 525146003524 substrate binding site [chemical binding]; other site 525146003525 dimer interface [polypeptide binding]; other site 525146003526 catalytic triad [active] 525146003527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 525146003528 Smr domain; Region: Smr; pfam01713 525146003529 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 525146003530 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 525146003531 MutS domain I; Region: MutS_I; pfam01624 525146003532 MutS domain II; Region: MutS_II; pfam05188 525146003533 MutS domain III; Region: MutS_III; pfam05192 525146003534 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 525146003535 Walker A/P-loop; other site 525146003536 ATP binding site [chemical binding]; other site 525146003537 Q-loop/lid; other site 525146003538 ABC transporter signature motif; other site 525146003539 Walker B; other site 525146003540 D-loop; other site 525146003541 H-loop/switch region; other site 525146003542 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 525146003543 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 525146003544 nucleotide binding site/active site [active] 525146003545 HIT family signature motif; other site 525146003546 catalytic residue [active] 525146003547 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 525146003548 FOG: CBS domain [General function prediction only]; Region: COG0517 525146003549 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 525146003550 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 525146003551 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 525146003552 active site 525146003553 NTP binding site [chemical binding]; other site 525146003554 metal binding triad [ion binding]; metal-binding site 525146003555 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 525146003556 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 525146003557 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525146003558 active site 525146003559 DNA binding site [nucleotide binding] 525146003560 Int/Topo IB signature motif; other site 525146003561 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 525146003562 catalytic center binding site [active] 525146003563 ATP binding site [chemical binding]; other site 525146003564 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 525146003565 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 525146003566 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 525146003567 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 525146003568 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 525146003569 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 525146003570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 525146003571 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 525146003572 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 525146003573 Peptidase family M23; Region: Peptidase_M23; pfam01551 525146003574 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 525146003575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146003576 S-adenosylmethionine binding site [chemical binding]; other site 525146003577 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 525146003578 Walker A motif; other site 525146003579 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 525146003580 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 525146003581 Septum formation initiator; Region: DivIC; pfam04977 525146003582 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 525146003583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146003584 TPR motif; other site 525146003585 binding surface 525146003586 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 525146003587 AMP binding site [chemical binding]; other site 525146003588 metal binding site [ion binding]; metal-binding site 525146003589 active site 525146003590 UGMP family protein; Validated; Region: PRK09604 525146003591 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 525146003592 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 525146003593 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 525146003594 catalytic residues [active] 525146003595 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 525146003596 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 525146003597 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525146003598 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 525146003599 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 525146003600 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 525146003601 Cation efflux family; Region: Cation_efflux; cl00316 525146003602 Cation efflux family; Region: Cation_efflux; cl00316 525146003603 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 525146003604 G1 box; other site 525146003605 GTP/Mg2+ binding site [chemical binding]; other site 525146003606 Switch I region; other site 525146003607 G2 box; other site 525146003608 G3 box; other site 525146003609 Switch II region; other site 525146003610 G4 box; other site 525146003611 G5 box; other site 525146003612 elongation factor P; Validated; Region: PRK00529 525146003613 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 525146003614 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 525146003615 RNA binding site [nucleotide binding]; other site 525146003616 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 525146003617 RNA binding site [nucleotide binding]; other site 525146003618 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 525146003619 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 525146003620 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 525146003621 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 525146003622 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 525146003623 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 525146003624 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 525146003625 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 525146003626 RNA binding site [nucleotide binding]; other site 525146003627 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 525146003628 RNA binding site [nucleotide binding]; other site 525146003629 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 525146003630 RNA binding site [nucleotide binding]; other site 525146003631 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 525146003632 RNA binding site [nucleotide binding]; other site 525146003633 domain interface; other site 525146003634 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 525146003635 RNA binding site [nucleotide binding]; other site 525146003636 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 525146003637 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 525146003638 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 525146003639 protein binding site [polypeptide binding]; other site 525146003640 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 525146003641 protein binding site [polypeptide binding]; other site 525146003642 phosphoglucomutase; Validated; Region: PRK07564 525146003643 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 525146003644 active site 525146003645 substrate binding site [chemical binding]; other site 525146003646 metal binding site [ion binding]; metal-binding site 525146003647 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 525146003648 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 525146003649 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525146003650 RNA binding surface [nucleotide binding]; other site 525146003651 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 525146003652 active site 525146003653 Putative exonuclease, RdgC; Region: RdgC; cl01122 525146003654 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 525146003655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146003656 dimer interface [polypeptide binding]; other site 525146003657 conserved gate region; other site 525146003658 putative PBP binding loops; other site 525146003659 ABC-ATPase subunit interface; other site 525146003660 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 525146003661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146003662 dimer interface [polypeptide binding]; other site 525146003663 conserved gate region; other site 525146003664 putative PBP binding loops; other site 525146003665 ABC-ATPase subunit interface; other site 525146003666 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 525146003667 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 525146003668 Walker A/P-loop; other site 525146003669 ATP binding site [chemical binding]; other site 525146003670 Q-loop/lid; other site 525146003671 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 525146003672 ABC transporter signature motif; other site 525146003673 Walker B; other site 525146003674 D-loop; other site 525146003675 H-loop/switch region; other site 525146003676 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 525146003677 Restriction endonuclease; Region: Mrr_cat; pfam04471 525146003678 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 525146003679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146003680 Walker A motif; other site 525146003681 ATP binding site [chemical binding]; other site 525146003682 Walker B motif; other site 525146003683 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 525146003684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525146003685 non-specific DNA binding site [nucleotide binding]; other site 525146003686 salt bridge; other site 525146003687 sequence-specific DNA binding site [nucleotide binding]; other site 525146003688 Domain of unknown function (DUF927); Region: DUF927; pfam06048 525146003689 Helix-turn-helix domain; Region: HTH_17; cl17695 525146003690 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 525146003691 integrase; Provisional; Region: PRK09692 525146003692 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 525146003693 active site 525146003694 Int/Topo IB signature motif; other site 525146003695 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525146003696 Zn2+ binding site [ion binding]; other site 525146003697 Mg2+ binding site [ion binding]; other site 525146003698 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 525146003699 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 525146003700 active site 525146003701 PHP Thumb interface [polypeptide binding]; other site 525146003702 metal binding site [ion binding]; metal-binding site 525146003703 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 525146003704 generic binding surface I; other site 525146003705 generic binding surface II; other site 525146003706 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 525146003707 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525146003708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 525146003709 binding surface 525146003710 TPR motif; other site 525146003711 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525146003712 heme-binding residues [chemical binding]; other site 525146003713 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525146003714 heme-binding residues [chemical binding]; other site 525146003715 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525146003716 heme-binding residues [chemical binding]; other site 525146003717 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 525146003718 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 525146003719 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 525146003720 FMN-binding domain; Region: FMN_bind; pfam04205 525146003721 electron transport complex RsxE subunit; Provisional; Region: PRK12405 525146003722 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 525146003723 ferredoxin; Validated; Region: PRK07118 525146003724 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 525146003725 ApbE family; Region: ApbE; pfam02424 525146003726 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 525146003727 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 525146003728 active site 525146003729 metal binding site [ion binding]; metal-binding site 525146003730 DNA binding site [nucleotide binding] 525146003731 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 525146003732 Uncharacterized conserved protein [Function unknown]; Region: COG4717 525146003733 Uncharacterized conserved protein [Function unknown]; Region: COG4717 525146003734 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 525146003735 nucleoside/Zn binding site; other site 525146003736 dimer interface [polypeptide binding]; other site 525146003737 catalytic motif [active] 525146003738 Uncharacterized conserved protein [Function unknown]; Region: COG0327 525146003739 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 525146003740 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 525146003741 Putative zinc ribbon domain; Region: DUF164; pfam02591 525146003742 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 525146003743 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 525146003744 substrate binding site; other site 525146003745 dimer interface; other site 525146003746 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 525146003747 homotrimer interaction site [polypeptide binding]; other site 525146003748 zinc binding site [ion binding]; other site 525146003749 CDP-binding sites; other site 525146003750 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 525146003751 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 525146003752 acyl-activating enzyme (AAE) consensus motif; other site 525146003753 putative AMP binding site [chemical binding]; other site 525146003754 putative active site [active] 525146003755 putative CoA binding site [chemical binding]; other site 525146003756 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 525146003757 putative active site [active] 525146003758 dimerization interface [polypeptide binding]; other site 525146003759 putative tRNAtyr binding site [nucleotide binding]; other site 525146003760 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 525146003761 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 525146003762 anti sigma factor interaction site; other site 525146003763 regulatory phosphorylation site [posttranslational modification]; other site 525146003764 Protein of unknown function (DUF342); Region: DUF342; pfam03961 525146003765 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 525146003766 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 525146003767 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 525146003768 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 525146003769 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 525146003770 putative active site [active] 525146003771 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 525146003772 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 525146003773 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 525146003774 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 525146003775 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 525146003776 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 525146003777 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 525146003778 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 525146003779 HTH-like domain; Region: HTH_21; pfam13276 525146003780 Integrase core domain; Region: rve; pfam00665 525146003781 Integrase core domain; Region: rve_3; pfam13683 525146003782 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 525146003783 DNA-binding interface [nucleotide binding]; DNA binding site 525146003784 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525146003785 dimerization interface [polypeptide binding]; other site 525146003786 putative DNA binding site [nucleotide binding]; other site 525146003787 putative Zn2+ binding site [ion binding]; other site 525146003788 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 525146003789 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525146003790 Soluble P-type ATPase [General function prediction only]; Region: COG4087 525146003791 Uncharacterized conserved protein [Function unknown]; Region: COG3603 525146003792 Family description; Region: ACT_7; pfam13840 525146003793 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 525146003794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146003795 Walker A motif; other site 525146003796 ATP binding site [chemical binding]; other site 525146003797 Walker B motif; other site 525146003798 arginine finger; other site 525146003799 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 525146003800 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14602 525146003801 RuvA N terminal domain; Region: RuvA_N; pfam01330 525146003802 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 525146003803 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146003804 FeS/SAM binding site; other site 525146003805 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 525146003806 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14337 525146003807 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 525146003808 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146003809 FeS/SAM binding site; other site 525146003810 Bifunctional nuclease; Region: DNase-RNase; pfam02577 525146003811 cellulose synthase A [UDP-forming], catalytic subunit; Region: PLN02915 525146003812 multidrug efflux protein; Reviewed; Region: PRK01766 525146003813 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 525146003814 cation binding site [ion binding]; other site 525146003815 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 525146003816 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 525146003817 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 525146003818 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 525146003819 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 525146003820 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 525146003821 GatB domain; Region: GatB_Yqey; smart00845 525146003822 Protein of unknown function DUF89; Region: DUF89; cl15397 525146003823 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 525146003824 ATP-NAD kinase; Region: NAD_kinase; pfam01513 525146003825 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 525146003826 dimer interface [polypeptide binding]; other site 525146003827 active site 525146003828 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 525146003829 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 525146003830 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 525146003831 domain interfaces; other site 525146003832 active site 525146003833 AAA domain; Region: AAA_32; pfam13654 525146003834 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 525146003835 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 525146003836 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525146003837 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525146003838 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 525146003839 Na binding site [ion binding]; other site 525146003840 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 525146003841 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 525146003842 Transglycosylase; Region: Transgly; pfam00912 525146003843 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 525146003844 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 525146003845 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 525146003846 MG2 domain; Region: A2M_N; pfam01835 525146003847 Alpha-2-macroglobulin family; Region: A2M; pfam00207 525146003848 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 525146003849 surface patch; other site 525146003850 thioester region; other site 525146003851 specificity defining residues; other site 525146003852 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 525146003853 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 525146003854 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 525146003855 Potassium binding sites [ion binding]; other site 525146003856 Cesium cation binding sites [ion binding]; other site 525146003857 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 525146003858 AAA domain; Region: AAA_26; pfam13500 525146003859 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 525146003860 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 525146003861 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 525146003862 inhibitor-cofactor binding pocket; inhibition site 525146003863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146003864 catalytic residue [active] 525146003865 biotin synthase; Region: bioB; TIGR00433 525146003866 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146003867 FeS/SAM binding site; other site 525146003868 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 525146003869 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 525146003870 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 525146003871 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 525146003872 Tetratricopeptide repeat; Region: TPR_6; pfam13174 525146003873 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 525146003874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146003875 Walker A motif; other site 525146003876 ATP binding site [chemical binding]; other site 525146003877 Walker B motif; other site 525146003878 arginine finger; other site 525146003879 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525146003880 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 525146003881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525146003882 ATP binding site [chemical binding]; other site 525146003883 putative Mg++ binding site [ion binding]; other site 525146003884 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525146003885 nucleotide binding region [chemical binding]; other site 525146003886 ATP-binding site [chemical binding]; other site 525146003887 Helicase associated domain (HA2); Region: HA2; pfam04408 525146003888 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 525146003889 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 525146003890 flavoprotein, HI0933 family; Region: TIGR00275 525146003891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 525146003892 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 525146003893 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 525146003894 Virulence factor SrfB; Region: SrfB; pfam07520 525146003895 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 525146003896 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 525146003897 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 525146003898 metal ion-dependent adhesion site (MIDAS); other site 525146003899 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525146003900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525146003901 Walker A/P-loop; other site 525146003902 ATP binding site [chemical binding]; other site 525146003903 Q-loop/lid; other site 525146003904 ABC transporter signature motif; other site 525146003905 Walker B; other site 525146003906 D-loop; other site 525146003907 H-loop/switch region; other site 525146003908 Uncharacterized conserved protein [Function unknown]; Region: COG1262 525146003909 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 525146003910 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 525146003911 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 525146003912 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 525146003913 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 525146003914 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 525146003915 active site 525146003916 catalytic site [active] 525146003917 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 525146003918 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 525146003919 Predicted ATPase [General function prediction only]; Region: COG3911 525146003920 AAA domain; Region: AAA_28; pfam13521 525146003921 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 525146003922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525146003923 Coenzyme A binding pocket [chemical binding]; other site 525146003924 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 525146003925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525146003926 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525146003927 Walker A/P-loop; other site 525146003928 ATP binding site [chemical binding]; other site 525146003929 Q-loop/lid; other site 525146003930 ABC transporter signature motif; other site 525146003931 Walker B; other site 525146003932 D-loop; other site 525146003933 H-loop/switch region; other site 525146003934 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 525146003935 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 525146003936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525146003937 Walker A/P-loop; other site 525146003938 ATP binding site [chemical binding]; other site 525146003939 Q-loop/lid; other site 525146003940 ABC transporter signature motif; other site 525146003941 Walker B; other site 525146003942 D-loop; other site 525146003943 H-loop/switch region; other site 525146003944 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 525146003945 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 525146003946 putative NAD(P) binding site [chemical binding]; other site 525146003947 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 525146003948 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 525146003949 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 525146003950 active site 525146003951 Methyltransferase domain; Region: Methyltransf_12; pfam08242 525146003952 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 525146003953 putative NADP binding site [chemical binding]; other site 525146003954 KR domain; Region: KR; pfam08659 525146003955 active site 525146003956 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 525146003957 Condensation domain; Region: Condensation; pfam00668 525146003958 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 525146003959 Nonribosomal peptide synthase; Region: NRPS; pfam08415 525146003960 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 525146003961 acyl-activating enzyme (AAE) consensus motif; other site 525146003962 AMP binding site [chemical binding]; other site 525146003963 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 525146003964 Thioesterase domain; Region: Thioesterase; pfam00975 525146003965 Condensation domain; Region: Condensation; pfam00668 525146003966 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 525146003967 Nonribosomal peptide synthase; Region: NRPS; pfam08415 525146003968 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 525146003969 acyl-activating enzyme (AAE) consensus motif; other site 525146003970 AMP binding site [chemical binding]; other site 525146003971 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 525146003972 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 525146003973 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 525146003974 active site 525146003975 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 525146003976 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 525146003977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525146003978 KR domain; Region: KR; pfam08659 525146003979 NAD(P) binding site [chemical binding]; other site 525146003980 active site 525146003981 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 525146003982 Phosphopantetheine attachment site; Region: PP-binding; cl09936 525146003983 Condensation domain; Region: Condensation; pfam00668 525146003984 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 525146003985 Nonribosomal peptide synthase; Region: NRPS; pfam08415 525146003986 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 525146003987 acyl-activating enzyme (AAE) consensus motif; other site 525146003988 AMP binding site [chemical binding]; other site 525146003989 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 525146003990 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 525146003991 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 525146003992 acyl-activating enzyme (AAE) consensus motif; other site 525146003993 active site 525146003994 AMP binding site [chemical binding]; other site 525146003995 substrate binding site [chemical binding]; other site 525146003996 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 525146003997 muropeptide transporter; Validated; Region: ampG; cl17669 525146003998 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 525146003999 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 525146004000 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 525146004001 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 525146004002 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 525146004003 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 525146004004 Walker A/P-loop; other site 525146004005 ATP binding site [chemical binding]; other site 525146004006 Q-loop/lid; other site 525146004007 ABC transporter signature motif; other site 525146004008 Walker B; other site 525146004009 D-loop; other site 525146004010 H-loop/switch region; other site 525146004011 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 525146004012 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525146004013 HlyD family secretion protein; Region: HlyD_3; pfam13437 525146004014 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 525146004015 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 525146004016 N-terminal plug; other site 525146004017 ligand-binding site [chemical binding]; other site 525146004018 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 525146004019 TolR protein; Region: tolR; TIGR02801 525146004020 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 525146004021 chorismate binding enzyme; Region: Chorismate_bind; cl10555 525146004022 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 525146004023 glycerol kinase; Provisional; Region: glpK; PRK00047 525146004024 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 525146004025 N- and C-terminal domain interface [polypeptide binding]; other site 525146004026 active site 525146004027 MgATP binding site [chemical binding]; other site 525146004028 catalytic site [active] 525146004029 metal binding site [ion binding]; metal-binding site 525146004030 glycerol binding site [chemical binding]; other site 525146004031 homotetramer interface [polypeptide binding]; other site 525146004032 homodimer interface [polypeptide binding]; other site 525146004033 FBP binding site [chemical binding]; other site 525146004034 protein IIAGlc interface [polypeptide binding]; other site 525146004035 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 525146004036 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 525146004037 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 525146004038 TrkA-C domain; Region: TrkA_C; pfam02080 525146004039 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 525146004040 TrkA-C domain; Region: TrkA_C; pfam02080 525146004041 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 525146004042 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525146004043 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525146004044 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525146004045 Tetratricopeptide repeat; Region: TPR_10; pfam13374 525146004046 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 525146004047 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 525146004048 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 525146004049 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 525146004050 DNA binding residues [nucleotide binding] 525146004051 drug binding residues [chemical binding]; other site 525146004052 dimer interface [polypeptide binding]; other site 525146004053 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 525146004054 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 525146004055 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 525146004056 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 525146004057 Hexamer interface [polypeptide binding]; other site 525146004058 Hexagonal pore residue; other site 525146004059 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 525146004060 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 525146004061 Hexamer interface [polypeptide binding]; other site 525146004062 Hexagonal pore residue; other site 525146004063 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 525146004064 putative catalytic cysteine [active] 525146004065 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 525146004066 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 525146004067 dimer interface [polypeptide binding]; other site 525146004068 active site 525146004069 glycine loop; other site 525146004070 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 525146004071 4Fe-4S binding domain; Region: Fer4; pfam00037 525146004072 4Fe-4S binding domain; Region: Fer4; cl02805 525146004073 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 525146004074 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 525146004075 Hexamer interface [polypeptide binding]; other site 525146004076 Hexagonal pore residue; other site 525146004077 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 525146004078 putative catalytic cysteine [active] 525146004079 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 525146004080 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 525146004081 Hexamer interface [polypeptide binding]; other site 525146004082 Putative hexagonal pore residue; other site 525146004083 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 525146004084 Propanediol utilisation protein PduL; Region: PduL; pfam06130 525146004085 Propanediol utilisation protein PduL; Region: PduL; pfam06130 525146004086 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 525146004087 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 525146004088 nucleotide binding site [chemical binding]; other site 525146004089 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 525146004090 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 525146004091 Hexamer/Pentamer interface [polypeptide binding]; other site 525146004092 central pore; other site 525146004093 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 525146004094 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 525146004095 putative hexamer interface [polypeptide binding]; other site 525146004096 putative hexagonal pore; other site 525146004097 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 525146004098 putative hexamer interface [polypeptide binding]; other site 525146004099 putative hexagonal pore; other site 525146004100 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 525146004101 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 525146004102 Hexamer interface [polypeptide binding]; other site 525146004103 Putative hexagonal pore residue; other site 525146004104 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 525146004105 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 525146004106 putative active site [active] 525146004107 metal binding site [ion binding]; metal-binding site 525146004108 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 525146004109 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 525146004110 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 525146004111 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 525146004112 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 525146004113 putative hexamer interface [polypeptide binding]; other site 525146004114 putative hexagonal pore; other site 525146004115 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 525146004116 putative hexamer interface [polypeptide binding]; other site 525146004117 putative hexagonal pore; other site 525146004118 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 525146004119 putative hexamer interface [polypeptide binding]; other site 525146004120 putative hexagonal pore; other site 525146004121 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 525146004122 Switch II region; other site 525146004123 G4 box; other site 525146004124 G5 box; other site 525146004125 Predicted membrane protein [Function unknown]; Region: COG2323 525146004126 hypothetical protein; Provisional; Region: PRK10457 525146004127 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 525146004128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146004129 active site 525146004130 phosphorylation site [posttranslational modification] 525146004131 intermolecular recognition site; other site 525146004132 CheB methylesterase; Region: CheB_methylest; pfam01339 525146004133 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 525146004134 HEAT repeats; Region: HEAT_2; pfam13646 525146004135 protein binding surface [polypeptide binding]; other site 525146004136 HEAT repeats; Region: HEAT_2; pfam13646 525146004137 HEAT repeats; Region: HEAT_2; pfam13646 525146004138 HEAT repeats; Region: HEAT_2; pfam13646 525146004139 HEAT repeats; Region: HEAT_2; pfam13646 525146004140 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 525146004141 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 525146004142 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 525146004143 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 525146004144 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525146004145 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525146004146 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 525146004147 Magnesium ion binding site [ion binding]; other site 525146004148 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 525146004149 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525146004150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146004151 active site 525146004152 phosphorylation site [posttranslational modification] 525146004153 intermolecular recognition site; other site 525146004154 dimerization interface [polypeptide binding]; other site 525146004155 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 525146004156 putative binding surface; other site 525146004157 active site 525146004158 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 525146004159 putative binding surface; other site 525146004160 active site 525146004161 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 525146004162 putative binding surface; other site 525146004163 active site 525146004164 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 525146004165 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 525146004166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146004167 ATP binding site [chemical binding]; other site 525146004168 Mg2+ binding site [ion binding]; other site 525146004169 G-X-G motif; other site 525146004170 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 525146004171 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 525146004172 Rhomboid family; Region: Rhomboid; cl11446 525146004173 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 525146004174 Rubredoxin; Region: Rubredoxin; pfam00301 525146004175 iron binding site [ion binding]; other site 525146004176 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 525146004177 Ferritin-like domain; Region: Ferritin; pfam00210 525146004178 heme binding site [chemical binding]; other site 525146004179 ferroxidase pore; other site 525146004180 ferroxidase diiron center [ion binding]; other site 525146004181 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 525146004182 metal binding site 2 [ion binding]; metal-binding site 525146004183 putative DNA binding helix; other site 525146004184 metal binding site 1 [ion binding]; metal-binding site 525146004185 dimer interface [polypeptide binding]; other site 525146004186 structural Zn2+ binding site [ion binding]; other site 525146004187 glucokinase, proteobacterial type; Region: glk; TIGR00749 525146004188 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 525146004189 nucleotide binding site [chemical binding]; other site 525146004190 Glucokinase; Region: Glucokinase; cl17310 525146004191 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 525146004192 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 525146004193 putative ribose interaction site [chemical binding]; other site 525146004194 putative ADP binding site [chemical binding]; other site 525146004195 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 525146004196 active site 525146004197 nucleotide binding site [chemical binding]; other site 525146004198 HIGH motif; other site 525146004199 KMSKS motif; other site 525146004200 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525146004201 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525146004202 Walker A/P-loop; other site 525146004203 ATP binding site [chemical binding]; other site 525146004204 Q-loop/lid; other site 525146004205 ABC transporter signature motif; other site 525146004206 Walker B; other site 525146004207 D-loop; other site 525146004208 H-loop/switch region; other site 525146004209 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525146004210 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525146004211 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525146004212 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 525146004213 FtsX-like permease family; Region: FtsX; pfam02687 525146004214 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525146004215 active site 525146004216 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 525146004217 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 525146004218 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525146004219 putative ADP-binding pocket [chemical binding]; other site 525146004220 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 525146004221 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 525146004222 EamA-like transporter family; Region: EamA; pfam00892 525146004223 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 525146004224 EamA-like transporter family; Region: EamA; pfam00892 525146004225 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 525146004226 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 525146004227 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 525146004228 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146004229 FeS/SAM binding site; other site 525146004230 intracellular protease, PfpI family; Region: PfpI; TIGR01382 525146004231 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 525146004232 conserved cys residue [active] 525146004233 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 525146004234 hypothetical protein; Provisional; Region: PRK11820 525146004235 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 525146004236 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 525146004237 hypothetical protein; Provisional; Region: PRK04323 525146004238 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 525146004239 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 525146004240 catalytic site [active] 525146004241 G-X2-G-X-G-K; other site 525146004242 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 525146004243 active site 525146004244 dimer interface [polypeptide binding]; other site 525146004245 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525146004246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146004247 binding surface 525146004248 TPR motif; other site 525146004249 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525146004250 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 525146004251 DHH family; Region: DHH; pfam01368 525146004252 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525146004253 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146004254 metal binding site [ion binding]; metal-binding site 525146004255 active site 525146004256 I-site; other site 525146004257 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 525146004258 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 525146004259 ligand binding site [chemical binding]; other site 525146004260 flexible hinge region; other site 525146004261 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 525146004262 benzoate transport; Region: 2A0115; TIGR00895 525146004263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525146004264 putative substrate translocation pore; other site 525146004265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525146004266 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 525146004267 catalytic residues [active] 525146004268 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 525146004269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525146004270 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 525146004271 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 525146004272 lipoyl attachment site [posttranslational modification]; other site 525146004273 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 525146004274 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 525146004275 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 525146004276 active site 525146004277 HIGH motif; other site 525146004278 KMSKS motif; other site 525146004279 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 525146004280 tRNA binding surface [nucleotide binding]; other site 525146004281 anticodon binding site; other site 525146004282 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 525146004283 dimer interface [polypeptide binding]; other site 525146004284 putative tRNA-binding site [nucleotide binding]; other site 525146004285 PSP1 C-terminal conserved region; Region: PSP1; cl00770 525146004286 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 525146004287 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 525146004288 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 525146004289 active site 525146004290 ADP/pyrophosphate binding site [chemical binding]; other site 525146004291 dimerization interface [polypeptide binding]; other site 525146004292 allosteric effector site; other site 525146004293 fructose-1,6-bisphosphate binding site; other site 525146004294 dihydrodipicolinate reductase; Provisional; Region: PRK00048 525146004295 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 525146004296 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 525146004297 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 525146004298 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 525146004299 nucleotide binding pocket [chemical binding]; other site 525146004300 K-X-D-G motif; other site 525146004301 catalytic site [active] 525146004302 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 525146004303 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 525146004304 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 525146004305 Dimer interface [polypeptide binding]; other site 525146004306 excinuclease ABC subunit B; Provisional; Region: PRK05298 525146004307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525146004308 ATP binding site [chemical binding]; other site 525146004309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525146004310 nucleotide binding region [chemical binding]; other site 525146004311 ATP-binding site [chemical binding]; other site 525146004312 Ultra-violet resistance protein B; Region: UvrB; pfam12344 525146004313 UvrB/uvrC motif; Region: UVR; pfam02151 525146004314 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 525146004315 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 525146004316 Clp amino terminal domain; Region: Clp_N; pfam02861 525146004317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146004318 Walker A motif; other site 525146004319 ATP binding site [chemical binding]; other site 525146004320 Walker B motif; other site 525146004321 arginine finger; other site 525146004322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146004323 Walker A motif; other site 525146004324 ATP binding site [chemical binding]; other site 525146004325 Walker B motif; other site 525146004326 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 525146004327 Uncharacterized conserved protein [Function unknown]; Region: COG2127 525146004328 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 525146004329 putative active site [active] 525146004330 putative metal binding residues [ion binding]; other site 525146004331 signature motif; other site 525146004332 putative triphosphate binding site [ion binding]; other site 525146004333 dimer interface [polypeptide binding]; other site 525146004334 DNA repair protein RadA; Provisional; Region: PRK11823 525146004335 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 525146004336 Walker A motif; other site 525146004337 ATP binding site [chemical binding]; other site 525146004338 Walker B motif; other site 525146004339 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525146004340 PAS domain; Region: PAS_9; pfam13426 525146004341 putative active site [active] 525146004342 heme pocket [chemical binding]; other site 525146004343 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 525146004344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146004345 Walker A motif; other site 525146004346 ATP binding site [chemical binding]; other site 525146004347 Walker B motif; other site 525146004348 arginine finger; other site 525146004349 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 525146004350 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 525146004351 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 525146004352 dimer interface [polypeptide binding]; other site 525146004353 active site 525146004354 glycine loop; other site 525146004355 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 525146004356 active site 525146004357 shikimate transporter; Provisional; Region: PRK09952 525146004358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525146004359 putative substrate translocation pore; other site 525146004360 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 525146004361 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525146004362 active site 525146004363 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 525146004364 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 525146004365 catalytic residues [active] 525146004366 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 525146004367 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 525146004368 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 525146004369 substrate binding pocket [chemical binding]; other site 525146004370 dihydropteroate synthase; Region: DHPS; TIGR01496 525146004371 dimer interface [polypeptide binding]; other site 525146004372 inhibitor binding site; inhibition site 525146004373 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 525146004374 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 525146004375 B12 binding site [chemical binding]; other site 525146004376 cobalt ligand [ion binding]; other site 525146004377 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 525146004378 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 525146004379 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 525146004380 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 525146004381 DNA binding residues [nucleotide binding] 525146004382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146004383 binding surface 525146004384 TPR motif; other site 525146004385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146004386 TPR motif; other site 525146004387 binding surface 525146004388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146004389 TPR motif; other site 525146004390 binding surface 525146004391 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 525146004392 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 525146004393 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 525146004394 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 525146004395 active site 525146004396 HIGH motif; other site 525146004397 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 525146004398 KMSKS motif; other site 525146004399 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 525146004400 tRNA binding surface [nucleotide binding]; other site 525146004401 anticodon binding site; other site 525146004402 Peptidase family M48; Region: Peptidase_M48; cl12018 525146004403 Tetratricopeptide repeat; Region: TPR_16; pfam13432 525146004404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146004405 binding surface 525146004406 TPR motif; other site 525146004407 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 525146004408 active site 525146004409 HslU subunit interaction site [polypeptide binding]; other site 525146004410 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14615 525146004411 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 525146004412 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 525146004413 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 525146004414 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525146004415 active site 525146004416 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 525146004417 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 525146004418 5S rRNA interface [nucleotide binding]; other site 525146004419 CTC domain interface [polypeptide binding]; other site 525146004420 L16 interface [polypeptide binding]; other site 525146004421 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 525146004422 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 525146004423 putative active site [active] 525146004424 catalytic residue [active] 525146004425 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 525146004426 transcription termination factor Rho; Provisional; Region: rho; PRK09376 525146004427 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 525146004428 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 525146004429 RNA binding site [nucleotide binding]; other site 525146004430 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 525146004431 multimer interface [polypeptide binding]; other site 525146004432 Walker A motif; other site 525146004433 ATP binding site [chemical binding]; other site 525146004434 Walker B motif; other site 525146004435 Cytochrome c; Region: Cytochrom_C; pfam00034 525146004436 DNA-specific endonuclease I; Provisional; Region: PRK15137 525146004437 Endonuclease I; Region: Endonuclease_1; pfam04231 525146004438 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 525146004439 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 525146004440 TolR protein; Region: tolR; TIGR02801 525146004441 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 525146004442 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 525146004443 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 525146004444 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 525146004445 Nitrogen regulatory protein P-II; Region: P-II; smart00938 525146004446 competence damage-inducible protein A; Provisional; Region: PRK00549 525146004447 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 525146004448 putative MPT binding site; other site 525146004449 Competence-damaged protein; Region: CinA; pfam02464 525146004450 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 525146004451 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 525146004452 homodimer interface [polypeptide binding]; other site 525146004453 substrate-cofactor binding pocket; other site 525146004454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146004455 catalytic residue [active] 525146004456 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 525146004457 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 525146004458 cobalt transport protein CbiM; Validated; Region: PRK06265 525146004459 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 525146004460 flagellar capping protein; Validated; Region: fliD; PRK08724 525146004461 Cobalt transport protein; Region: CbiQ; cl00463 525146004462 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 525146004463 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525146004464 Walker A/P-loop; other site 525146004465 ATP binding site [chemical binding]; other site 525146004466 Q-loop/lid; other site 525146004467 ABC transporter signature motif; other site 525146004468 Walker B; other site 525146004469 D-loop; other site 525146004470 H-loop/switch region; other site 525146004471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525146004472 PAS fold; Region: PAS_3; pfam08447 525146004473 putative active site [active] 525146004474 heme pocket [chemical binding]; other site 525146004475 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525146004476 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146004477 metal binding site [ion binding]; metal-binding site 525146004478 active site 525146004479 I-site; other site 525146004480 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525146004481 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 525146004482 RNA binding surface [nucleotide binding]; other site 525146004483 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 525146004484 active site 525146004485 GTP-binding protein Der; Reviewed; Region: PRK00093 525146004486 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 525146004487 G1 box; other site 525146004488 GTP/Mg2+ binding site [chemical binding]; other site 525146004489 Switch I region; other site 525146004490 G2 box; other site 525146004491 Switch II region; other site 525146004492 G3 box; other site 525146004493 G4 box; other site 525146004494 G5 box; other site 525146004495 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 525146004496 G1 box; other site 525146004497 GTP/Mg2+ binding site [chemical binding]; other site 525146004498 Switch I region; other site 525146004499 G2 box; other site 525146004500 G3 box; other site 525146004501 Switch II region; other site 525146004502 G4 box; other site 525146004503 G5 box; other site 525146004504 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 525146004505 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 525146004506 dimerization interface [polypeptide binding]; other site 525146004507 ligand binding site [chemical binding]; other site 525146004508 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525146004509 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 525146004510 TM-ABC transporter signature motif; other site 525146004511 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 525146004512 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 525146004513 TM-ABC transporter signature motif; other site 525146004514 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 525146004515 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 525146004516 Walker A/P-loop; other site 525146004517 ATP binding site [chemical binding]; other site 525146004518 Q-loop/lid; other site 525146004519 ABC transporter signature motif; other site 525146004520 Walker B; other site 525146004521 D-loop; other site 525146004522 H-loop/switch region; other site 525146004523 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 525146004524 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 525146004525 Walker A/P-loop; other site 525146004526 ATP binding site [chemical binding]; other site 525146004527 Q-loop/lid; other site 525146004528 ABC transporter signature motif; other site 525146004529 Walker B; other site 525146004530 D-loop; other site 525146004531 H-loop/switch region; other site 525146004532 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 525146004533 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 525146004534 active site 525146004535 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 525146004536 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 525146004537 Ion channel; Region: Ion_trans_2; pfam07885 525146004538 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 525146004539 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 525146004540 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 525146004541 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 525146004542 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 525146004543 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 525146004544 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 525146004545 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 525146004546 Walker A/P-loop; other site 525146004547 ATP binding site [chemical binding]; other site 525146004548 Q-loop/lid; other site 525146004549 ABC transporter signature motif; other site 525146004550 Walker B; other site 525146004551 D-loop; other site 525146004552 H-loop/switch region; other site 525146004553 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 525146004554 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 525146004555 Walker A/P-loop; other site 525146004556 ATP binding site [chemical binding]; other site 525146004557 Q-loop/lid; other site 525146004558 ABC transporter signature motif; other site 525146004559 Walker B; other site 525146004560 D-loop; other site 525146004561 H-loop/switch region; other site 525146004562 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 525146004563 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 525146004564 HlyD family secretion protein; Region: HlyD_3; pfam13437 525146004565 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 525146004566 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 525146004567 tetramer interface [polypeptide binding]; other site 525146004568 heme binding pocket [chemical binding]; other site 525146004569 NADPH binding site [chemical binding]; other site 525146004570 Sporulation related domain; Region: SPOR; pfam05036 525146004571 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525146004572 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 525146004573 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 525146004574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146004575 TPR motif; other site 525146004576 binding surface 525146004577 AMIN domain; Region: AMIN; pfam11741 525146004578 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 525146004579 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 525146004580 G1 box; other site 525146004581 GTP/Mg2+ binding site [chemical binding]; other site 525146004582 Switch I region; other site 525146004583 G2 box; other site 525146004584 Switch II region; other site 525146004585 G3 box; other site 525146004586 G4 box; other site 525146004587 G5 box; other site 525146004588 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 525146004589 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 525146004590 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 525146004591 4Fe-4S binding domain; Region: Fer4; pfam00037 525146004592 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 525146004593 biotin synthase; Provisional; Region: PRK07094 525146004594 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 525146004595 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 525146004596 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146004597 FeS/SAM binding site; other site 525146004598 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 525146004599 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 525146004600 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 525146004601 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 525146004602 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 525146004603 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 525146004604 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 525146004605 Domain of unknown function (DUF364); Region: DUF364; pfam04016 525146004606 Methyltransferase domain; Region: Methyltransf_31; pfam13847 525146004607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146004608 S-adenosylmethionine binding site [chemical binding]; other site 525146004609 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 525146004610 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 525146004611 active site 525146004612 metal binding site [ion binding]; metal-binding site 525146004613 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 525146004614 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 525146004615 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 525146004616 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 525146004617 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 525146004618 Walker A/P-loop; other site 525146004619 ATP binding site [chemical binding]; other site 525146004620 Q-loop/lid; other site 525146004621 ABC transporter signature motif; other site 525146004622 Walker B; other site 525146004623 D-loop; other site 525146004624 H-loop/switch region; other site 525146004625 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 525146004626 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 525146004627 ABC-ATPase subunit interface; other site 525146004628 dimer interface [polypeptide binding]; other site 525146004629 putative PBP binding regions; other site 525146004630 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 525146004631 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 525146004632 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 525146004633 N-terminal plug; other site 525146004634 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 525146004635 ligand-binding site [chemical binding]; other site 525146004636 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 525146004637 Ligand Binding Site [chemical binding]; other site 525146004638 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 525146004639 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 525146004640 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 525146004641 Cysteine-rich domain; Region: CCG; pfam02754 525146004642 Cysteine-rich domain; Region: CCG; pfam02754 525146004643 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 525146004644 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 525146004645 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 525146004646 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 525146004647 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 525146004648 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525146004649 DctM-like transporters; Region: DctM; pfam06808 525146004650 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 525146004651 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 525146004652 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 525146004653 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 525146004654 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 525146004655 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 525146004656 transmembrane helices; other site 525146004657 fumarate hydratase; Provisional; Region: PRK06246 525146004658 Fumarase C-terminus; Region: Fumerase_C; cl00795 525146004659 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 525146004660 Iron-sulfur protein interface; other site 525146004661 proximal heme binding site [chemical binding]; other site 525146004662 distal heme binding site [chemical binding]; other site 525146004663 dimer interface [polypeptide binding]; other site 525146004664 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 525146004665 L-aspartate oxidase; Provisional; Region: PRK06175 525146004666 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 525146004667 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 525146004668 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 525146004669 FOG: CBS domain [General function prediction only]; Region: COG0517 525146004670 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 525146004671 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 525146004672 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 525146004673 Malic enzyme, N-terminal domain; Region: malic; pfam00390 525146004674 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 525146004675 putative NAD(P) binding site [chemical binding]; other site 525146004676 sensory histidine kinase DcuS; Provisional; Region: PRK11086 525146004677 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 525146004678 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525146004679 Zn2+ binding site [ion binding]; other site 525146004680 Mg2+ binding site [ion binding]; other site 525146004681 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 525146004682 synthetase active site [active] 525146004683 NTP binding site [chemical binding]; other site 525146004684 metal binding site [ion binding]; metal-binding site 525146004685 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 525146004686 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 525146004687 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 525146004688 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 525146004689 peptide binding site [polypeptide binding]; other site 525146004690 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 525146004691 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 525146004692 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525146004693 ATP binding site [chemical binding]; other site 525146004694 putative Mg++ binding site [ion binding]; other site 525146004695 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525146004696 nucleotide binding region [chemical binding]; other site 525146004697 ATP-binding site [chemical binding]; other site 525146004698 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 525146004699 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 525146004700 Walker A/P-loop; other site 525146004701 ATP binding site [chemical binding]; other site 525146004702 Q-loop/lid; other site 525146004703 ABC transporter signature motif; other site 525146004704 Walker B; other site 525146004705 D-loop; other site 525146004706 H-loop/switch region; other site 525146004707 NIL domain; Region: NIL; pfam09383 525146004708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146004709 dimer interface [polypeptide binding]; other site 525146004710 conserved gate region; other site 525146004711 ABC-ATPase subunit interface; other site 525146004712 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 525146004713 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 525146004714 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 525146004715 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 525146004716 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 525146004717 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 525146004718 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 525146004719 catalytic loop [active] 525146004720 iron binding site [ion binding]; other site 525146004721 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 525146004722 4Fe-4S binding domain; Region: Fer4; pfam00037 525146004723 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525146004724 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525146004725 molybdopterin cofactor binding site; other site 525146004726 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 525146004727 molybdopterin cofactor binding site; other site 525146004728 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 525146004729 FAD binding domain; Region: FAD_binding_4; pfam01565 525146004730 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525146004731 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 525146004732 oligomerisation interface [polypeptide binding]; other site 525146004733 mobile loop; other site 525146004734 roof hairpin; other site 525146004735 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 525146004736 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 525146004737 ring oligomerisation interface [polypeptide binding]; other site 525146004738 ATP/Mg binding site [chemical binding]; other site 525146004739 stacking interactions; other site 525146004740 hinge regions; other site 525146004741 UV-endonuclease UvdE; Region: UvdE; cl10036 525146004742 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 525146004743 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525146004744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525146004745 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 525146004746 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 525146004747 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 525146004748 pyruvate carboxylase; Reviewed; Region: PRK12999 525146004749 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 525146004750 ATP-grasp domain; Region: ATP-grasp_4; cl17255 525146004751 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 525146004752 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 525146004753 active site 525146004754 catalytic residues [active] 525146004755 metal binding site [ion binding]; metal-binding site 525146004756 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 525146004757 carboxyltransferase (CT) interaction site; other site 525146004758 biotinylation site [posttranslational modification]; other site 525146004759 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 525146004760 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 525146004761 metal binding triad [ion binding]; metal-binding site 525146004762 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 525146004763 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 525146004764 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 525146004765 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525146004766 Zn2+ binding site [ion binding]; other site 525146004767 Mg2+ binding site [ion binding]; other site 525146004768 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 525146004769 PhoH-like protein; Region: PhoH; pfam02562 525146004770 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 525146004771 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525146004772 substrate binding pocket [chemical binding]; other site 525146004773 membrane-bound complex binding site; other site 525146004774 hinge residues; other site 525146004775 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 525146004776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146004777 dimer interface [polypeptide binding]; other site 525146004778 conserved gate region; other site 525146004779 putative PBP binding loops; other site 525146004780 ABC-ATPase subunit interface; other site 525146004781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146004782 dimer interface [polypeptide binding]; other site 525146004783 conserved gate region; other site 525146004784 putative PBP binding loops; other site 525146004785 ABC-ATPase subunit interface; other site 525146004786 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525146004787 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 525146004788 Walker A/P-loop; other site 525146004789 ATP binding site [chemical binding]; other site 525146004790 Q-loop/lid; other site 525146004791 ABC transporter signature motif; other site 525146004792 Walker B; other site 525146004793 D-loop; other site 525146004794 H-loop/switch region; other site 525146004795 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 525146004796 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 525146004797 dimerization interface [polypeptide binding]; other site 525146004798 ligand binding site [chemical binding]; other site 525146004799 NADP binding site [chemical binding]; other site 525146004800 catalytic site [active] 525146004801 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 525146004802 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 525146004803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146004804 Response regulator receiver domain; Region: Response_reg; pfam00072 525146004805 active site 525146004806 phosphorylation site [posttranslational modification] 525146004807 intermolecular recognition site; other site 525146004808 dimerization interface [polypeptide binding]; other site 525146004809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525146004810 dimer interface [polypeptide binding]; other site 525146004811 phosphorylation site [posttranslational modification] 525146004812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146004813 ATP binding site [chemical binding]; other site 525146004814 G-X-G motif; other site 525146004815 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 525146004816 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 525146004817 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 525146004818 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 525146004819 Walker A motif/ATP binding site; other site 525146004820 Walker B motif; other site 525146004821 flagellar assembly protein H; Validated; Region: fliH; PRK06669 525146004822 Flagellar assembly protein FliH; Region: FliH; pfam02108 525146004823 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 525146004824 MgtE intracellular N domain; Region: MgtE_N; cl15244 525146004825 FliG C-terminal domain; Region: FliG_C; pfam01706 525146004826 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 525146004827 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 525146004828 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 525146004829 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 525146004830 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 525146004831 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 525146004832 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 525146004833 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12621 525146004834 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 525146004835 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 525146004836 ParB-like nuclease domain; Region: ParBc; pfam02195 525146004837 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 525146004838 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 525146004839 Active Sites [active] 525146004840 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 525146004841 Cache domain; Region: Cache_1; pfam02743 525146004842 HAMP domain; Region: HAMP; pfam00672 525146004843 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146004844 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146004845 dimer interface [polypeptide binding]; other site 525146004846 putative CheW interface [polypeptide binding]; other site 525146004847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 525146004848 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 525146004849 active site 525146004850 catalytic site [active] 525146004851 substrate binding site [chemical binding]; other site 525146004852 Staphylococcal nuclease homologues; Region: SNc; smart00318 525146004853 Catalytic site; other site 525146004854 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 525146004855 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 525146004856 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 525146004857 G1 box; other site 525146004858 GTP/Mg2+ binding site [chemical binding]; other site 525146004859 Switch I region; other site 525146004860 G2 box; other site 525146004861 G3 box; other site 525146004862 Switch II region; other site 525146004863 G4 box; other site 525146004864 G5 box; other site 525146004865 Nucleoside recognition; Region: Gate; pfam07670 525146004866 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 525146004867 Nucleoside recognition; Region: Gate; pfam07670 525146004868 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 525146004869 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 525146004870 substrate binding site [chemical binding]; other site 525146004871 active site 525146004872 catalytic residues [active] 525146004873 heterodimer interface [polypeptide binding]; other site 525146004874 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 525146004875 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 525146004876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146004877 catalytic residue [active] 525146004878 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 525146004879 active site 525146004880 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 525146004881 active site 525146004882 ribulose/triose binding site [chemical binding]; other site 525146004883 phosphate binding site [ion binding]; other site 525146004884 substrate (anthranilate) binding pocket [chemical binding]; other site 525146004885 product (indole) binding pocket [chemical binding]; other site 525146004886 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK14607 525146004887 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 525146004888 glutamine binding [chemical binding]; other site 525146004889 catalytic triad [active] 525146004890 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 525146004891 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 525146004892 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 525146004893 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 525146004894 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 525146004895 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 525146004896 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 525146004897 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 525146004898 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 525146004899 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 525146004900 diaminopimelate decarboxylase; Region: lysA; TIGR01048 525146004901 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 525146004902 active site 525146004903 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 525146004904 substrate binding site [chemical binding]; other site 525146004905 catalytic residues [active] 525146004906 dimer interface [polypeptide binding]; other site 525146004907 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 525146004908 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 525146004909 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 525146004910 hypothetical protein; Provisional; Region: PRK02237 525146004911 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 525146004912 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 525146004913 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 525146004914 NlpC/P60 family; Region: NLPC_P60; cl17555 525146004915 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 525146004916 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525146004917 RNA binding surface [nucleotide binding]; other site 525146004918 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 525146004919 active site 525146004920 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 525146004921 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 525146004922 CoA-binding site [chemical binding]; other site 525146004923 ATP-binding [chemical binding]; other site 525146004924 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 525146004925 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 525146004926 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 525146004927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525146004928 dimer interface [polypeptide binding]; other site 525146004929 phosphorylation site [posttranslational modification] 525146004930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146004931 ATP binding site [chemical binding]; other site 525146004932 Mg2+ binding site [ion binding]; other site 525146004933 G-X-G motif; other site 525146004934 Response regulator receiver domain; Region: Response_reg; pfam00072 525146004935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146004936 active site 525146004937 phosphorylation site [posttranslational modification] 525146004938 intermolecular recognition site; other site 525146004939 dimerization interface [polypeptide binding]; other site 525146004940 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 525146004941 putative deacylase active site [active] 525146004942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 525146004943 nucleotide binding site [chemical binding]; other site 525146004944 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 525146004945 Sel1-like repeats; Region: SEL1; smart00671 525146004946 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 525146004947 GIY-YIG motif/motif A; other site 525146004948 putative active site [active] 525146004949 putative metal binding site [ion binding]; other site 525146004950 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 525146004951 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 525146004952 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 525146004953 putative phosphate acyltransferase; Provisional; Region: PRK05331 525146004954 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 525146004955 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 525146004956 dimer interface [polypeptide binding]; other site 525146004957 active site 525146004958 CoA binding pocket [chemical binding]; other site 525146004959 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 525146004960 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 525146004961 NAD(P) binding site [chemical binding]; other site 525146004962 homotetramer interface [polypeptide binding]; other site 525146004963 homodimer interface [polypeptide binding]; other site 525146004964 active site 525146004965 acyl carrier protein; Provisional; Region: acpP; PRK00982 525146004966 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 525146004967 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 525146004968 dimer interface [polypeptide binding]; other site 525146004969 active site 525146004970 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 525146004971 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 525146004972 dimer interface [polypeptide binding]; other site 525146004973 active site 525146004974 glycine-pyridoxal phosphate binding site [chemical binding]; other site 525146004975 folate binding site [chemical binding]; other site 525146004976 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 525146004977 catalytic motif [active] 525146004978 Zn binding site [ion binding]; other site 525146004979 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 525146004980 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 525146004981 catalytic motif [active] 525146004982 Zn binding site [ion binding]; other site 525146004983 RibD C-terminal domain; Region: RibD_C; cl17279 525146004984 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 525146004985 Lumazine binding domain; Region: Lum_binding; pfam00677 525146004986 Lumazine binding domain; Region: Lum_binding; pfam00677 525146004987 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 525146004988 homopentamer interface [polypeptide binding]; other site 525146004989 active site 525146004990 transcription antitermination factor NusB; Region: nusB; TIGR01951 525146004991 putative RNA binding site [nucleotide binding]; other site 525146004992 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 525146004993 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 525146004994 HIGH motif; other site 525146004995 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 525146004996 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525146004997 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 525146004998 active site 525146004999 KMSKS motif; other site 525146005000 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 525146005001 tRNA binding surface [nucleotide binding]; other site 525146005002 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 525146005003 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 525146005004 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 525146005005 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 525146005006 helix-hairpin-helix signature motif; other site 525146005007 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 525146005008 MPN+ (JAMM) motif; other site 525146005009 Zinc-binding site [ion binding]; other site 525146005010 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 525146005011 Found in ATP-dependent protease La (LON); Region: LON; smart00464 525146005012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146005013 Walker A motif; other site 525146005014 ATP binding site [chemical binding]; other site 525146005015 Walker B motif; other site 525146005016 arginine finger; other site 525146005017 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 525146005018 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 525146005019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146005020 S-adenosylmethionine binding site [chemical binding]; other site 525146005021 elongation factor Tu; Reviewed; Region: PRK00049 525146005022 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 525146005023 G1 box; other site 525146005024 GEF interaction site [polypeptide binding]; other site 525146005025 GTP/Mg2+ binding site [chemical binding]; other site 525146005026 Switch I region; other site 525146005027 G2 box; other site 525146005028 G3 box; other site 525146005029 Switch II region; other site 525146005030 G4 box; other site 525146005031 G5 box; other site 525146005032 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 525146005033 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 525146005034 Antibiotic Binding Site [chemical binding]; other site 525146005035 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 525146005036 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 525146005037 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 525146005038 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 525146005039 putative homodimer interface [polypeptide binding]; other site 525146005040 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 525146005041 heterodimer interface [polypeptide binding]; other site 525146005042 homodimer interface [polypeptide binding]; other site 525146005043 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 525146005044 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 525146005045 23S rRNA interface [nucleotide binding]; other site 525146005046 L7/L12 interface [polypeptide binding]; other site 525146005047 putative thiostrepton binding site; other site 525146005048 L25 interface [polypeptide binding]; other site 525146005049 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 525146005050 mRNA/rRNA interface [nucleotide binding]; other site 525146005051 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 525146005052 23S rRNA interface [nucleotide binding]; other site 525146005053 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 525146005054 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 525146005055 peripheral dimer interface [polypeptide binding]; other site 525146005056 core dimer interface [polypeptide binding]; other site 525146005057 L10 interface [polypeptide binding]; other site 525146005058 L11 interface [polypeptide binding]; other site 525146005059 putative EF-Tu interaction site [polypeptide binding]; other site 525146005060 putative EF-G interaction site [polypeptide binding]; other site 525146005061 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 525146005062 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 525146005063 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 525146005064 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 525146005065 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 525146005066 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 525146005067 RPB3 interaction site [polypeptide binding]; other site 525146005068 RPB1 interaction site [polypeptide binding]; other site 525146005069 RPB11 interaction site [polypeptide binding]; other site 525146005070 RPB10 interaction site [polypeptide binding]; other site 525146005071 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 525146005072 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 525146005073 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 525146005074 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 525146005075 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 525146005076 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 525146005077 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 525146005078 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 525146005079 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 525146005080 DNA binding site [nucleotide binding] 525146005081 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 525146005082 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525146005083 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 525146005084 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525146005085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146005086 Walker A motif; other site 525146005087 ATP binding site [chemical binding]; other site 525146005088 Walker B motif; other site 525146005089 arginine finger; other site 525146005090 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 525146005091 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 525146005092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525146005093 putative substrate translocation pore; other site 525146005094 Major Facilitator Superfamily; Region: MFS_1; pfam07690 525146005095 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525146005096 active site residue [active] 525146005097 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 525146005098 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 525146005099 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 525146005100 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 525146005101 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 525146005102 active site 525146005103 FMN binding site [chemical binding]; other site 525146005104 substrate binding site [chemical binding]; other site 525146005105 homotetramer interface [polypeptide binding]; other site 525146005106 catalytic residue [active] 525146005107 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 525146005108 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 525146005109 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 525146005110 Predicted membrane protein [Function unknown]; Region: COG1422 525146005111 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525146005112 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 525146005113 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 525146005114 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 525146005115 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 525146005116 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 525146005117 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 525146005118 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 525146005119 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 525146005120 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 525146005121 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 525146005122 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 525146005123 4Fe-4S binding domain; Region: Fer4; pfam00037 525146005124 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 525146005125 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 525146005126 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 525146005127 NADH dehydrogenase subunit D; Validated; Region: PRK06075 525146005128 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 525146005129 NADH dehydrogenase subunit B; Validated; Region: PRK06411 525146005130 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 525146005131 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 525146005132 thiosulfate reductase PhsA; Provisional; Region: PRK15488 525146005133 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 525146005134 putative [Fe4-S4] binding site [ion binding]; other site 525146005135 putative molybdopterin cofactor binding site [chemical binding]; other site 525146005136 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 525146005137 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 525146005138 putative molybdopterin cofactor binding site; other site 525146005139 4Fe-4S binding domain; Region: Fer4; pfam00037 525146005140 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525146005141 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 525146005142 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 525146005143 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 525146005144 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 525146005145 NADH dehydrogenase; Region: NADHdh; cl00469 525146005146 hydrogenase 4 subunit F; Validated; Region: PRK06458 525146005147 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 525146005148 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 525146005149 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146005150 metal binding site [ion binding]; metal-binding site 525146005151 active site 525146005152 I-site; other site 525146005153 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 525146005154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525146005155 Coenzyme A binding pocket [chemical binding]; other site 525146005156 ornithine carbamoyltransferase; Validated; Region: PRK02102 525146005157 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 525146005158 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 525146005159 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 525146005160 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 525146005161 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525146005162 K+-transporting ATPase, c chain; Region: KdpC; cl00944 525146005163 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 525146005164 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 525146005165 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 525146005166 Ligand Binding Site [chemical binding]; other site 525146005167 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 525146005168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525146005169 dimer interface [polypeptide binding]; other site 525146005170 phosphorylation site [posttranslational modification] 525146005171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146005172 ATP binding site [chemical binding]; other site 525146005173 Mg2+ binding site [ion binding]; other site 525146005174 G-X-G motif; other site 525146005175 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525146005176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146005177 active site 525146005178 phosphorylation site [posttranslational modification] 525146005179 intermolecular recognition site; other site 525146005180 dimerization interface [polypeptide binding]; other site 525146005181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525146005182 DNA binding site [nucleotide binding] 525146005183 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 525146005184 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 525146005185 active site 525146005186 regulatory protein UhpC; Provisional; Region: PRK11663 525146005187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525146005188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525146005189 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 525146005190 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 525146005191 inhibitor site; inhibition site 525146005192 active site 525146005193 dimer interface [polypeptide binding]; other site 525146005194 catalytic residue [active] 525146005195 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 525146005196 hydroxyglutarate oxidase; Provisional; Region: PRK11728 525146005197 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 525146005198 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 525146005199 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 525146005200 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 525146005201 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 525146005202 NAD(P) binding site [chemical binding]; other site 525146005203 catalytic residues [active] 525146005204 proline racemase; Provisional; Region: PRK13969 525146005205 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 525146005206 amino acid transporter; Region: 2A0306; TIGR00909 525146005207 Spore germination protein; Region: Spore_permease; cl17796 525146005208 phosphodiesterase; Provisional; Region: PRK12704 525146005209 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 525146005210 Zn2+ binding site [ion binding]; other site 525146005211 Mg2+ binding site [ion binding]; other site 525146005212 Cell division protein ZapA; Region: ZapA; pfam05164 525146005213 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14356 525146005214 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 525146005215 Substrate binding site; other site 525146005216 Mg++ binding site; other site 525146005217 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 525146005218 active site 525146005219 substrate binding site [chemical binding]; other site 525146005220 CoA binding site [chemical binding]; other site 525146005221 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 525146005222 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525146005223 active site 525146005224 OsmC-like protein; Region: OsmC; pfam02566 525146005225 Predicted membrane protein [Function unknown]; Region: COG1971 525146005226 Domain of unknown function DUF; Region: DUF204; pfam02659 525146005227 Domain of unknown function DUF; Region: DUF204; pfam02659 525146005228 magnesium-transporting ATPase; Provisional; Region: PRK15122 525146005229 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 525146005230 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525146005231 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 525146005232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525146005233 motif II; other site 525146005234 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 525146005235 benzoylformate decarboxylase; Reviewed; Region: PRK07092 525146005236 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 525146005237 PYR/PP interface [polypeptide binding]; other site 525146005238 dimer interface [polypeptide binding]; other site 525146005239 TPP binding site [chemical binding]; other site 525146005240 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 525146005241 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 525146005242 TPP-binding site [chemical binding]; other site 525146005243 dimer interface [polypeptide binding]; other site 525146005244 Membrane transport protein; Region: Mem_trans; cl09117 525146005245 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 525146005246 MoaD interaction [polypeptide binding]; other site 525146005247 active site residues [active] 525146005248 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 525146005249 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 525146005250 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 525146005251 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525146005252 nucleotide binding region [chemical binding]; other site 525146005253 ATP-binding site [chemical binding]; other site 525146005254 SEC-C motif; Region: SEC-C; pfam02810 525146005255 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 525146005256 primosome assembly protein PriA; Validated; Region: PRK05580 525146005257 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 525146005258 ATP binding site [chemical binding]; other site 525146005259 putative Mg++ binding site [ion binding]; other site 525146005260 helicase superfamily c-terminal domain; Region: HELICc; smart00490 525146005261 ATP-binding site [chemical binding]; other site 525146005262 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 525146005263 active site 525146005264 tetramer interface; other site 525146005265 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 525146005266 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 525146005267 active site 525146005268 substrate binding site [chemical binding]; other site 525146005269 metal binding site [ion binding]; metal-binding site 525146005270 YbbR-like protein; Region: YbbR; pfam07949 525146005271 YbbR-like protein; Region: YbbR; pfam07949 525146005272 Uncharacterized conserved protein [Function unknown]; Region: COG1624 525146005273 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 525146005274 dihydropteroate synthase; Region: DHPS; TIGR01496 525146005275 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 525146005276 substrate binding pocket [chemical binding]; other site 525146005277 dimer interface [polypeptide binding]; other site 525146005278 inhibitor binding site; inhibition site 525146005279 FtsH Extracellular; Region: FtsH_ext; pfam06480 525146005280 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 525146005281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146005282 Walker A motif; other site 525146005283 ATP binding site [chemical binding]; other site 525146005284 Walker B motif; other site 525146005285 arginine finger; other site 525146005286 Peptidase family M41; Region: Peptidase_M41; pfam01434 525146005287 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 525146005288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 525146005289 DNA-binding site [nucleotide binding]; DNA binding site 525146005290 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 525146005291 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 525146005292 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525146005293 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 525146005294 twin arginine translocase protein A; Provisional; Region: tatA; PRK14859 525146005295 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 525146005296 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 525146005297 ATP binding site [chemical binding]; other site 525146005298 Mg++ binding site [ion binding]; other site 525146005299 motif III; other site 525146005300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 525146005301 nucleotide binding region [chemical binding]; other site 525146005302 ATP-binding site [chemical binding]; other site 525146005303 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 525146005304 RNA binding site [nucleotide binding]; other site 525146005305 molybdenum transport protein ModD; Provisional; Region: PRK06096 525146005306 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 525146005307 dimerization interface [polypeptide binding]; other site 525146005308 active site 525146005309 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 525146005310 VWA-like domain (DUF2201); Region: DUF2201; pfam09967 525146005311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146005312 Walker A motif; other site 525146005313 ATP binding site [chemical binding]; other site 525146005314 Walker B motif; other site 525146005315 arginine finger; other site 525146005316 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 525146005317 metal binding site [ion binding]; metal-binding site 525146005318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146005319 TPR motif; other site 525146005320 binding surface 525146005321 Tetratricopeptide repeat; Region: TPR_12; pfam13424 525146005322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146005323 binding surface 525146005324 TPR motif; other site 525146005325 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525146005326 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 525146005327 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 525146005328 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 525146005329 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 525146005330 active site 525146005331 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 525146005332 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 525146005333 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 525146005334 active site 525146005335 NTP binding site [chemical binding]; other site 525146005336 metal binding triad [ion binding]; metal-binding site 525146005337 antibiotic binding site [chemical binding]; other site 525146005338 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 525146005339 Tim44-like domain; Region: Tim44; pfam04280 525146005340 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 525146005341 CoenzymeA binding site [chemical binding]; other site 525146005342 subunit interaction site [polypeptide binding]; other site 525146005343 PHB binding site; other site 525146005344 hypothetical protein; Provisional; Region: PRK11019 525146005345 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 525146005346 selenocysteine synthase; Provisional; Region: PRK04311 525146005347 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 525146005348 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 525146005349 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525146005350 catalytic residue [active] 525146005351 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 525146005352 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 525146005353 oligomer interface [polypeptide binding]; other site 525146005354 putative active site [active] 525146005355 metal binding site [ion binding]; metal-binding site 525146005356 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 525146005357 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 525146005358 Sterol carrier protein domain; Region: SCP2_2; pfam13530 525146005359 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 525146005360 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 525146005361 active site 525146005362 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 525146005363 Trm112p-like protein; Region: Trm112p; cl01066 525146005364 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 525146005365 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 525146005366 active site 525146005367 metal binding site [ion binding]; metal-binding site 525146005368 homotetramer interface [polypeptide binding]; other site 525146005369 Maf-like protein; Region: Maf; pfam02545 525146005370 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 525146005371 active site 525146005372 dimer interface [polypeptide binding]; other site 525146005373 acetyl-CoA synthetase; Provisional; Region: PRK00174 525146005374 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 525146005375 active site 525146005376 CoA binding site [chemical binding]; other site 525146005377 acyl-activating enzyme (AAE) consensus motif; other site 525146005378 AMP binding site [chemical binding]; other site 525146005379 acetate binding site [chemical binding]; other site 525146005380 FeoA domain; Region: FeoA; pfam04023 525146005381 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 525146005382 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525146005383 Soluble P-type ATPase [General function prediction only]; Region: COG4087 525146005384 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 525146005385 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525146005386 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 525146005387 putative active site [active] 525146005388 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 525146005389 Bacterial sugar transferase; Region: Bac_transf; pfam02397 525146005390 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525146005391 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 525146005392 substrate binding pocket [chemical binding]; other site 525146005393 membrane-bound complex binding site; other site 525146005394 hinge residues; other site 525146005395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146005396 dimer interface [polypeptide binding]; other site 525146005397 conserved gate region; other site 525146005398 putative PBP binding loops; other site 525146005399 ABC-ATPase subunit interface; other site 525146005400 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 525146005401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525146005402 Walker A/P-loop; other site 525146005403 ATP binding site [chemical binding]; other site 525146005404 Q-loop/lid; other site 525146005405 ABC transporter signature motif; other site 525146005406 Walker B; other site 525146005407 D-loop; other site 525146005408 H-loop/switch region; other site 525146005409 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 525146005410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146005411 dimer interface [polypeptide binding]; other site 525146005412 conserved gate region; other site 525146005413 putative PBP binding loops; other site 525146005414 ABC-ATPase subunit interface; other site 525146005415 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525146005416 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146005417 metal binding site [ion binding]; metal-binding site 525146005418 active site 525146005419 I-site; other site 525146005420 GAF domain; Region: GAF; pfam01590 525146005421 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525146005422 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146005423 metal binding site [ion binding]; metal-binding site 525146005424 active site 525146005425 I-site; other site 525146005426 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 525146005427 threonine dehydratase; Reviewed; Region: PRK09224 525146005428 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 525146005429 tetramer interface [polypeptide binding]; other site 525146005430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146005431 catalytic residue [active] 525146005432 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 525146005433 putative Ile/Val binding site [chemical binding]; other site 525146005434 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 525146005435 putative Ile/Val binding site [chemical binding]; other site 525146005436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146005437 S-adenosylmethionine binding site [chemical binding]; other site 525146005438 nickel responsive regulator; Provisional; Region: PRK04460 525146005439 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 525146005440 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 525146005441 putative GTP cyclohydrolase; Provisional; Region: PRK13674 525146005442 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 525146005443 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 525146005444 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 525146005445 NlpC/P60 family; Region: NLPC_P60; pfam00877 525146005446 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 525146005447 active site 525146005448 HIGH motif; other site 525146005449 nucleotide binding site [chemical binding]; other site 525146005450 active site 525146005451 KMSKS motif; other site 525146005452 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 525146005453 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 525146005454 dimer interface [polypeptide binding]; other site 525146005455 putative functional site; other site 525146005456 putative MPT binding site; other site 525146005457 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 525146005458 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 525146005459 dimer interface [polypeptide binding]; other site 525146005460 putative functional site; other site 525146005461 putative MPT binding site; other site 525146005462 PBP superfamily domain; Region: PBP_like; pfam12727 525146005463 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 525146005464 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 525146005465 ATP binding site [chemical binding]; other site 525146005466 substrate interface [chemical binding]; other site 525146005467 ThiS family; Region: ThiS; pfam02597 525146005468 charged pocket; other site 525146005469 hydrophobic patch; other site 525146005470 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 525146005471 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 525146005472 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 525146005473 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 525146005474 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 525146005475 Walker A/P-loop; other site 525146005476 ATP binding site [chemical binding]; other site 525146005477 Q-loop/lid; other site 525146005478 ABC transporter signature motif; other site 525146005479 Walker B; other site 525146005480 D-loop; other site 525146005481 H-loop/switch region; other site 525146005482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 525146005483 dimer interface [polypeptide binding]; other site 525146005484 conserved gate region; other site 525146005485 putative PBP binding loops; other site 525146005486 ABC-ATPase subunit interface; other site 525146005487 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 525146005488 PBP superfamily domain; Region: PBP_like_2; pfam12849 525146005489 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 525146005490 active site 525146005491 catalytic residues [active] 525146005492 Int/Topo IB signature motif; other site 525146005493 DNA binding site [nucleotide binding] 525146005494 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 525146005495 Transcriptional regulators [Transcription]; Region: PurR; COG1609 525146005496 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 525146005497 DNA binding site [nucleotide binding] 525146005498 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 525146005499 ligand binding site [chemical binding]; other site 525146005500 dimerization interface [polypeptide binding]; other site 525146005501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525146005502 metabolite-proton symporter; Region: 2A0106; TIGR00883 525146005503 putative substrate translocation pore; other site 525146005504 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 525146005505 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 525146005506 active site 525146005507 metal binding site [ion binding]; metal-binding site 525146005508 hexamer interface [polypeptide binding]; other site 525146005509 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 525146005510 elongation factor G; Reviewed; Region: PRK12740 525146005511 G1 box; other site 525146005512 putative GEF interaction site [polypeptide binding]; other site 525146005513 GTP/Mg2+ binding site [chemical binding]; other site 525146005514 Switch I region; other site 525146005515 G2 box; other site 525146005516 G3 box; other site 525146005517 Switch II region; other site 525146005518 G4 box; other site 525146005519 G5 box; other site 525146005520 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 525146005521 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 525146005522 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 525146005523 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525146005524 non-specific DNA binding site [nucleotide binding]; other site 525146005525 salt bridge; other site 525146005526 sequence-specific DNA binding site [nucleotide binding]; other site 525146005527 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 525146005528 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; cl17853 525146005529 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 525146005530 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 525146005531 RNA/DNA hybrid binding site [nucleotide binding]; other site 525146005532 active site 525146005533 hypothetical protein; Provisional; Region: PRK14680 525146005534 Predicted methyltransferases [General function prediction only]; Region: COG0313 525146005535 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 525146005536 putative SAM binding site [chemical binding]; other site 525146005537 putative homodimer interface [polypeptide binding]; other site 525146005538 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 525146005539 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 525146005540 regulatory protein interface [polypeptide binding]; other site 525146005541 active site 525146005542 regulatory phosphorylation site [posttranslational modification]; other site 525146005543 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 525146005544 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 525146005545 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 525146005546 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 525146005547 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 525146005548 SmpB-tmRNA interface; other site 525146005549 Competence protein; Region: Competence; pfam03772 525146005550 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525146005551 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 525146005552 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 525146005553 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 525146005554 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 525146005555 DNA binding site [nucleotide binding] 525146005556 catalytic residue [active] 525146005557 H2TH interface [polypeptide binding]; other site 525146005558 putative catalytic residues [active] 525146005559 turnover-facilitating residue; other site 525146005560 intercalation triad [nucleotide binding]; other site 525146005561 8OG recognition residue [nucleotide binding]; other site 525146005562 putative reading head residues; other site 525146005563 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 525146005564 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 525146005565 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 525146005566 RimM N-terminal domain; Region: RimM; pfam01782 525146005567 PRC-barrel domain; Region: PRC; pfam05239 525146005568 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 525146005569 hypothetical protein; Provisional; Region: PRK00468 525146005570 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 525146005571 signal recognition particle protein; Provisional; Region: PRK10867 525146005572 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 525146005573 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 525146005574 P loop; other site 525146005575 GTP binding site [chemical binding]; other site 525146005576 Signal peptide binding domain; Region: SRP_SPB; pfam02978 525146005577 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 525146005578 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 525146005579 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 525146005580 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 525146005581 active site 525146005582 GMP synthase; Reviewed; Region: guaA; PRK00074 525146005583 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 525146005584 AMP/PPi binding site [chemical binding]; other site 525146005585 candidate oxyanion hole; other site 525146005586 catalytic triad [active] 525146005587 potential glutamine specificity residues [chemical binding]; other site 525146005588 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 525146005589 ATP Binding subdomain [chemical binding]; other site 525146005590 Ligand Binding sites [chemical binding]; other site 525146005591 Dimerization subdomain; other site 525146005592 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 525146005593 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 525146005594 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 525146005595 putative active site pocket [active] 525146005596 4-fold oligomerization interface [polypeptide binding]; other site 525146005597 metal binding residues [ion binding]; metal-binding site 525146005598 3-fold/trimer interface [polypeptide binding]; other site 525146005599 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 525146005600 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 525146005601 catalytic residues [active] 525146005602 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 525146005603 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 525146005604 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 525146005605 catalytic core [active] 525146005606 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 525146005607 Ligand binding site; other site 525146005608 metal-binding site 525146005609 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525146005610 acyl-activating enzyme (AAE) consensus motif; other site 525146005611 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 525146005612 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525146005613 AMP binding site [chemical binding]; other site 525146005614 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 525146005615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146005616 FeS/SAM binding site; other site 525146005617 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 525146005618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146005619 Methyltransferase domain; Region: Methyltransf_31; pfam13847 525146005620 S-adenosylmethionine binding site [chemical binding]; other site 525146005621 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 525146005622 Cysteine-rich domain; Region: CCG; pfam02754 525146005623 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 525146005624 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 525146005625 catalytic loop [active] 525146005626 iron binding site [ion binding]; other site 525146005627 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 525146005628 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 525146005629 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 525146005630 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 525146005631 putative MPT binding site; other site 525146005632 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 525146005633 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 525146005634 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 525146005635 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 525146005636 ligand binding site [chemical binding]; other site 525146005637 flexible hinge region; other site 525146005638 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 525146005639 putative switch regulator; other site 525146005640 non-specific DNA interactions [nucleotide binding]; other site 525146005641 DNA binding site [nucleotide binding] 525146005642 sequence specific DNA binding site [nucleotide binding]; other site 525146005643 putative cAMP binding site [chemical binding]; other site 525146005644 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 525146005645 hybrid cluster protein; Provisional; Region: PRK05290 525146005646 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525146005647 ACS interaction site; other site 525146005648 CODH interaction site; other site 525146005649 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 525146005650 hybrid metal cluster; other site 525146005651 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 525146005652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146005653 S-adenosylmethionine binding site [chemical binding]; other site 525146005654 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 525146005655 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 525146005656 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 525146005657 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 525146005658 active site 525146005659 dimer interface [polypeptide binding]; other site 525146005660 effector binding site; other site 525146005661 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 525146005662 TSCPD domain; Region: TSCPD; pfam12637 525146005663 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 525146005664 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 525146005665 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 525146005666 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 525146005667 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 525146005668 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 525146005669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525146005670 active site 525146005671 motif I; other site 525146005672 motif II; other site 525146005673 hypothetical protein; Provisional; Region: PRK11770 525146005674 Domain of unknown function (DUF307); Region: DUF307; pfam03733 525146005675 Domain of unknown function (DUF307); Region: DUF307; pfam03733 525146005676 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 525146005677 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 525146005678 dimerization interface [polypeptide binding]; other site 525146005679 putative ATP binding site [chemical binding]; other site 525146005680 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 525146005681 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146005682 FeS/SAM binding site; other site 525146005683 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 525146005684 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 525146005685 BON domain; Region: BON; pfam04972 525146005686 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 525146005687 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 525146005688 hinge; other site 525146005689 active site 525146005690 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 525146005691 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 525146005692 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 525146005693 putative active site [active] 525146005694 putative metal binding residues [ion binding]; other site 525146005695 signature motif; other site 525146005696 putative dimer interface [polypeptide binding]; other site 525146005697 putative phosphate binding site [ion binding]; other site 525146005698 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 525146005699 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 525146005700 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 525146005701 dimer interface [polypeptide binding]; other site 525146005702 substrate binding site [chemical binding]; other site 525146005703 metal binding sites [ion binding]; metal-binding site 525146005704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 525146005705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 525146005706 LysR substrate binding domain; Region: LysR_substrate; pfam03466 525146005707 dimerization interface [polypeptide binding]; other site 525146005708 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 525146005709 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 525146005710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525146005711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525146005712 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 525146005713 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 525146005714 DNA binding residues [nucleotide binding] 525146005715 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 525146005716 Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579 525146005717 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 525146005718 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 525146005719 P loop nucleotide binding; other site 525146005720 switch II; other site 525146005721 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525146005722 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525146005723 4Fe-4S binding domain; Region: Fer4; pfam00037 525146005724 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525146005725 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 525146005726 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 525146005727 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 525146005728 putative ligand binding pocket/active site [active] 525146005729 putative metal binding site [ion binding]; other site 525146005730 succinic semialdehyde dehydrogenase; Region: PLN02278 525146005731 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 525146005732 tetramerization interface [polypeptide binding]; other site 525146005733 NAD(P) binding site [chemical binding]; other site 525146005734 catalytic residues [active] 525146005735 dihydroorotase; Validated; Region: pyrC; PRK09357 525146005736 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 525146005737 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 525146005738 active site 525146005739 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 525146005740 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 525146005741 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 525146005742 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525146005743 Uncharacterized conserved protein [Function unknown]; Region: COG1284 525146005744 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 525146005745 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 525146005746 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 525146005747 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 525146005748 active site 525146005749 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 525146005750 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 525146005751 metal-binding site [ion binding] 525146005752 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 525146005753 Soluble P-type ATPase [General function prediction only]; Region: COG4087 525146005754 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 525146005755 metal-binding site [ion binding] 525146005756 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 525146005757 active site 525146005758 Zn binding site [ion binding]; other site 525146005759 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 525146005760 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 525146005761 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 525146005762 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 525146005763 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 525146005764 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 525146005765 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 525146005766 NADH dehydrogenase; Region: NADHdh; cl00469 525146005767 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 525146005768 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 525146005769 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 525146005770 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 525146005771 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 525146005772 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 525146005773 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 525146005774 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 525146005775 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 525146005776 Sel1-like repeats; Region: SEL1; smart00671 525146005777 Sel1-like repeats; Region: SEL1; smart00671 525146005778 Sel1-like repeats; Region: SEL1; smart00671 525146005779 Sel1-like repeats; Region: SEL1; smart00671 525146005780 Sel1-like repeats; Region: SEL1; smart00671 525146005781 Sel1-like repeats; Region: SEL1; smart00671 525146005782 Sel1-like repeats; Region: SEL1; smart00671 525146005783 putative transferase, LIC12162 family; Region: o_ant_LIC12162; TIGR04331 525146005784 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 525146005785 NeuB family; Region: NeuB; pfam03102 525146005786 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 525146005787 NeuB binding interface [polypeptide binding]; other site 525146005788 putative substrate binding site [chemical binding]; other site 525146005789 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 525146005790 EamA-like transporter family; Region: EamA; pfam00892 525146005791 EamA-like transporter family; Region: EamA; pfam00892 525146005792 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 525146005793 active site 525146005794 dimerization interface [polypeptide binding]; other site 525146005795 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 525146005796 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 525146005797 Walker A/P-loop; other site 525146005798 ATP binding site [chemical binding]; other site 525146005799 Q-loop/lid; other site 525146005800 ABC transporter signature motif; other site 525146005801 Walker B; other site 525146005802 D-loop; other site 525146005803 H-loop/switch region; other site 525146005804 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 525146005805 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 525146005806 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 525146005807 CPxP motif; other site 525146005808 DsrE/DsrF-like family; Region: DrsE; pfam02635 525146005809 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146005810 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146005811 dimer interface [polypeptide binding]; other site 525146005812 putative CheW interface [polypeptide binding]; other site 525146005813 Hemerythrin; Region: Hemerythrin; cd12107 525146005814 Fe binding site [ion binding]; other site 525146005815 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 525146005816 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 525146005817 predicted active site [active] 525146005818 catalytic triad [active] 525146005819 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 525146005820 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 525146005821 active site 525146005822 multimer interface [polypeptide binding]; other site 525146005823 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 525146005824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525146005825 motif II; other site 525146005826 YGGT family; Region: YGGT; pfam02325 525146005827 isoleucyl-tRNA synthetase; Region: PLN02843 525146005828 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 525146005829 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 525146005830 PYR/PP interface [polypeptide binding]; other site 525146005831 dimer interface [polypeptide binding]; other site 525146005832 TPP binding site [chemical binding]; other site 525146005833 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 525146005834 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 525146005835 TPP-binding site [chemical binding]; other site 525146005836 dimer interface [polypeptide binding]; other site 525146005837 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 525146005838 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 525146005839 putative valine binding site [chemical binding]; other site 525146005840 dimer interface [polypeptide binding]; other site 525146005841 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 525146005842 ketol-acid reductoisomerase; Provisional; Region: PRK05479 525146005843 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 525146005844 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 525146005845 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 525146005846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146005847 S-adenosylmethionine binding site [chemical binding]; other site 525146005848 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275 525146005849 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 525146005850 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 525146005851 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 525146005852 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 525146005853 futalosine nucleosidase; Region: fut_nucase; TIGR03664 525146005854 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 525146005855 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 525146005856 substrate binding pocket [chemical binding]; other site 525146005857 chain length determination region; other site 525146005858 substrate-Mg2+ binding site; other site 525146005859 catalytic residues [active] 525146005860 aspartate-rich region 1; other site 525146005861 active site lid residues [active] 525146005862 aspartate-rich region 2; other site 525146005863 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 525146005864 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 525146005865 dimerization interface [polypeptide binding]; other site 525146005866 ATP binding site [chemical binding]; other site 525146005867 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 525146005868 dimerization interface [polypeptide binding]; other site 525146005869 ATP binding site [chemical binding]; other site 525146005870 hypothetical protein; Provisional; Region: PRK04194 525146005871 FOG: CBS domain [General function prediction only]; Region: COG0517 525146005872 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 525146005873 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 525146005874 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 525146005875 DsrC like protein; Region: DsrC; pfam04358 525146005876 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 525146005877 Transglycosylase; Region: Transgly; pfam00912 525146005878 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 525146005879 RNA binding site [nucleotide binding]; other site 525146005880 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 525146005881 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 525146005882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 525146005883 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 525146005884 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 525146005885 NADP binding site [chemical binding]; other site 525146005886 homopentamer interface [polypeptide binding]; other site 525146005887 substrate binding site [chemical binding]; other site 525146005888 active site 525146005889 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 525146005890 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 525146005891 Walker A/P-loop; other site 525146005892 ATP binding site [chemical binding]; other site 525146005893 Q-loop/lid; other site 525146005894 ABC transporter signature motif; other site 525146005895 Walker B; other site 525146005896 D-loop; other site 525146005897 H-loop/switch region; other site 525146005898 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 525146005899 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 525146005900 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 525146005901 active site 525146005902 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 525146005903 dimerization interface [polypeptide binding]; other site 525146005904 putative DNA binding site [nucleotide binding]; other site 525146005905 putative Zn2+ binding site [ion binding]; other site 525146005906 Methyltransferase domain; Region: Methyltransf_31; pfam13847 525146005907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146005908 S-adenosylmethionine binding site [chemical binding]; other site 525146005909 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 525146005910 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 525146005911 Protein export membrane protein; Region: SecD_SecF; pfam02355 525146005912 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 525146005913 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 525146005914 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 525146005915 Preprotein translocase subunit; Region: YajC; pfam02699 525146005916 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 525146005917 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 525146005918 active site 525146005919 putative substrate binding pocket [chemical binding]; other site 525146005920 diaminopimelate aminotransferase; Provisional; Region: PRK13983 525146005921 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650 525146005922 metal binding site [ion binding]; metal-binding site 525146005923 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 525146005924 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 525146005925 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 525146005926 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 525146005927 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 525146005928 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 525146005929 Transporter associated domain; Region: CorC_HlyC; smart01091 525146005930 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 525146005931 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 525146005932 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 525146005933 putative active site [active] 525146005934 catalytic triad [active] 525146005935 putative dimer interface [polypeptide binding]; other site 525146005936 peptide chain release factor 2; Validated; Region: prfB; PRK00578 525146005937 This domain is found in peptide chain release factors; Region: PCRF; smart00937 525146005938 RF-1 domain; Region: RF-1; pfam00472 525146005939 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 525146005940 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525146005941 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 525146005942 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 525146005943 IHF - DNA interface [nucleotide binding]; other site 525146005944 IHF dimer interface [polypeptide binding]; other site 525146005945 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 525146005946 dihydrodipicolinate synthase; Region: dapA; TIGR00674 525146005947 dimer interface [polypeptide binding]; other site 525146005948 active site 525146005949 catalytic residue [active] 525146005950 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 525146005951 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 525146005952 dimer interface [polypeptide binding]; other site 525146005953 active site 525146005954 metal binding site [ion binding]; metal-binding site 525146005955 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 525146005956 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146005957 FeS/SAM binding site; other site 525146005958 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 525146005959 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 525146005960 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525146005961 NMT1/THI5 like; Region: NMT1; pfam09084 525146005962 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 525146005963 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 525146005964 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 525146005965 methionine sulfoxide reductase A; Provisional; Region: PRK14054 525146005966 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 525146005967 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 525146005968 NAD binding site [chemical binding]; other site 525146005969 homodimer interface [polypeptide binding]; other site 525146005970 active site 525146005971 substrate binding site [chemical binding]; other site 525146005972 flavodoxin, short chain; Region: flav_short; TIGR01753 525146005973 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146005974 Radical SAM superfamily; Region: Radical_SAM; pfam04055 525146005975 FeS/SAM binding site; other site 525146005976 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 525146005977 AsmA family; Region: AsmA; pfam05170 525146005978 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 525146005979 adenylate kinase; Provisional; Region: PRK14529 525146005980 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 525146005981 AMP-binding site [chemical binding]; other site 525146005982 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 525146005983 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 525146005984 trimer interface [polypeptide binding]; other site 525146005985 active site 525146005986 acetylornithine aminotransferase; Provisional; Region: PRK02627 525146005987 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 525146005988 inhibitor-cofactor binding pocket; inhibition site 525146005989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146005990 catalytic residue [active] 525146005991 phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419 525146005992 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 525146005993 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 525146005994 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 525146005995 RNA binding surface [nucleotide binding]; other site 525146005996 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 525146005997 active site 525146005998 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 525146005999 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 525146006000 phosphate binding site [ion binding]; other site 525146006001 putative substrate binding pocket [chemical binding]; other site 525146006002 dimer interface [polypeptide binding]; other site 525146006003 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 525146006004 catalytic site [active] 525146006005 putative active site [active] 525146006006 putative substrate binding site [chemical binding]; other site 525146006007 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 525146006008 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 525146006009 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 525146006010 G1 box; other site 525146006011 GTP/Mg2+ binding site [chemical binding]; other site 525146006012 trmE is a tRNA modification GTPase; Region: trmE; cd04164 525146006013 GTP/Mg2+ binding site [chemical binding]; other site 525146006014 Switch I region; other site 525146006015 Switch I region; other site 525146006016 G2 box; other site 525146006017 G2 box; other site 525146006018 Switch II region; other site 525146006019 G3 box; other site 525146006020 G4 box; other site 525146006021 G5 box; other site 525146006022 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 525146006023 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 525146006024 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 525146006025 G-X-X-G motif; other site 525146006026 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 525146006027 RxxxH motif; other site 525146006028 membrane protein insertase; Provisional; Region: PRK01318 525146006029 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 525146006030 Haemolytic domain; Region: Haemolytic; pfam01809 525146006031 Ribonuclease P; Region: Ribonuclease_P; pfam00825 525146006032 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 525146006033 shikimate kinase; Reviewed; Region: aroK; PRK00131 525146006034 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 525146006035 ADP binding site [chemical binding]; other site 525146006036 magnesium binding site [ion binding]; other site 525146006037 putative shikimate binding site; other site 525146006038 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 525146006039 metal ion-dependent adhesion site (MIDAS); other site 525146006040 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 525146006041 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 525146006042 ligand binding site [chemical binding]; other site 525146006043 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 525146006044 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 525146006045 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 525146006046 active site 525146006047 putative homodimer interface [polypeptide binding]; other site 525146006048 SAM binding site [chemical binding]; other site 525146006049 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 525146006050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 525146006051 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 525146006052 active site 525146006053 SAM binding site [chemical binding]; other site 525146006054 homodimer interface [polypeptide binding]; other site 525146006055 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 525146006056 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 525146006057 NAD(P) binding site [chemical binding]; other site 525146006058 catalytic residues [active] 525146006059 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 525146006060 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 525146006061 FAD binding pocket [chemical binding]; other site 525146006062 FAD binding motif [chemical binding]; other site 525146006063 phosphate binding motif [ion binding]; other site 525146006064 beta-alpha-beta structure motif; other site 525146006065 NAD binding pocket [chemical binding]; other site 525146006066 Iron coordination center [ion binding]; other site 525146006067 putative oxidoreductase; Provisional; Region: PRK12831 525146006068 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 525146006069 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 525146006070 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 525146006071 histidinol-phosphatase; Provisional; Region: PRK07328 525146006072 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 525146006073 active site 525146006074 dimer interface [polypeptide binding]; other site 525146006075 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525146006076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525146006077 Walker A/P-loop; other site 525146006078 ATP binding site [chemical binding]; other site 525146006079 Q-loop/lid; other site 525146006080 ABC transporter signature motif; other site 525146006081 Walker B; other site 525146006082 D-loop; other site 525146006083 H-loop/switch region; other site 525146006084 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 525146006085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525146006086 Walker A/P-loop; other site 525146006087 ATP binding site [chemical binding]; other site 525146006088 Q-loop/lid; other site 525146006089 ABC transporter signature motif; other site 525146006090 Walker B; other site 525146006091 D-loop; other site 525146006092 H-loop/switch region; other site 525146006093 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 525146006094 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 525146006095 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 525146006096 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 525146006097 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 525146006098 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525146006099 Cysteine-rich domain; Region: CCG; pfam02754 525146006100 Cysteine-rich domain; Region: CCG; pfam02754 525146006101 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 525146006102 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 525146006103 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525146006104 Cysteine-rich domain; Region: CCG; pfam02754 525146006105 Cysteine-rich domain; Region: CCG; pfam02754 525146006106 FAD binding domain; Region: FAD_binding_4; pfam01565 525146006107 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 525146006108 Autotransporter beta-domain; Region: Autotransporter; smart00869 525146006109 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 525146006110 flagellar assembly protein FliW; Provisional; Region: PRK13285 525146006111 Global regulator protein family; Region: CsrA; pfam02599 525146006112 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 525146006113 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 525146006114 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 525146006115 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 525146006116 FlgN protein; Region: FlgN; pfam05130 525146006117 Rod binding protein; Region: Rod-binding; pfam10135 525146006118 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 525146006119 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 525146006120 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 525146006121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525146006122 putative substrate translocation pore; other site 525146006123 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 525146006124 FAD binding site [chemical binding]; other site 525146006125 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 525146006126 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 525146006127 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 525146006128 non-heme iron binding site [ion binding]; other site 525146006129 dimer interface [polypeptide binding]; other site 525146006130 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 525146006131 non-heme iron binding site [ion binding]; other site 525146006132 dimer interface [polypeptide binding]; other site 525146006133 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 525146006134 Rubredoxin; Region: Rubredoxin; pfam00301 525146006135 iron binding site [ion binding]; other site 525146006136 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 525146006137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525146006138 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 525146006139 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525146006140 heme-binding residues [chemical binding]; other site 525146006141 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 525146006142 active site 525146006143 SAM binding site [chemical binding]; other site 525146006144 homodimer interface [polypeptide binding]; other site 525146006145 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 525146006146 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 525146006147 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 525146006148 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 525146006149 inhibitor-cofactor binding pocket; inhibition site 525146006150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146006151 catalytic residue [active] 525146006152 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 525146006153 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 525146006154 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 525146006155 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 525146006156 replicative DNA helicase; Region: DnaB; TIGR00665 525146006157 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 525146006158 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 525146006159 Walker A motif; other site 525146006160 ATP binding site [chemical binding]; other site 525146006161 Walker B motif; other site 525146006162 DNA binding loops [nucleotide binding] 525146006163 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 525146006164 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 525146006165 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 525146006166 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 525146006167 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 525146006168 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 525146006169 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 525146006170 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 525146006171 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 525146006172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146006173 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 525146006174 nucleoside/Zn binding site; other site 525146006175 dimer interface [polypeptide binding]; other site 525146006176 catalytic motif [active] 525146006177 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 525146006178 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 525146006179 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 525146006180 Beta-Casp domain; Region: Beta-Casp; smart01027 525146006181 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 525146006182 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 525146006183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146006184 S-adenosylmethionine binding site [chemical binding]; other site 525146006185 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 525146006186 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 525146006187 active site 525146006188 (T/H)XGH motif; other site 525146006189 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 525146006190 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 525146006191 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 525146006192 active site clefts [active] 525146006193 zinc binding site [ion binding]; other site 525146006194 dimer interface [polypeptide binding]; other site 525146006195 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525146006196 heme-binding residues [chemical binding]; other site 525146006197 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 525146006198 heme-binding residues [chemical binding]; other site 525146006199 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 525146006200 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 525146006201 Methyltransferase domain; Region: Methyltransf_12; pfam08242 525146006202 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 525146006203 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 525146006204 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 525146006205 catalytic residue [active] 525146006206 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 525146006207 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 525146006208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 525146006209 motif II; other site 525146006210 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 525146006211 trimer interface [polypeptide binding]; other site 525146006212 active site 525146006213 substrate binding site [chemical binding]; other site 525146006214 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 525146006215 CoA binding site [chemical binding]; other site 525146006216 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 525146006217 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 525146006218 Ligand binding site; other site 525146006219 oligomer interface; other site 525146006220 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 525146006221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525146006222 NAD(P) binding site [chemical binding]; other site 525146006223 active site 525146006224 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 525146006225 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 525146006226 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 525146006227 MPT binding site; other site 525146006228 PBP superfamily domain; Region: PBP_like; pfam12727 525146006229 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 525146006230 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 525146006231 putative active site [active] 525146006232 metal binding site [ion binding]; metal-binding site 525146006233 molybdenum-pterin binding domain; Region: Mop; TIGR00638 525146006234 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 525146006235 Peptidase family M48; Region: Peptidase_M48; cl12018 525146006236 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 525146006237 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 525146006238 active site 525146006239 dimer interface [polypeptide binding]; other site 525146006240 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 525146006241 Ligand Binding Site [chemical binding]; other site 525146006242 Molecular Tunnel; other site 525146006243 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 525146006244 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525146006245 putative ADP-binding pocket [chemical binding]; other site 525146006246 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 525146006247 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 525146006248 putative ADP-binding pocket [chemical binding]; other site 525146006249 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525146006250 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 525146006251 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 525146006252 substrate-cofactor binding pocket; other site 525146006253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146006254 catalytic residue [active] 525146006255 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 525146006256 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 525146006257 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 525146006258 Outer membrane efflux protein; Region: OEP; pfam02321 525146006259 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 525146006260 HlyD family secretion protein; Region: HlyD_3; pfam13437 525146006261 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 525146006262 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 525146006263 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 525146006264 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 525146006265 heterotetramer interface [polypeptide binding]; other site 525146006266 active site pocket [active] 525146006267 cleavage site 525146006268 elongation factor G; Reviewed; Region: PRK00007 525146006269 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 525146006270 G1 box; other site 525146006271 putative GEF interaction site [polypeptide binding]; other site 525146006272 GTP/Mg2+ binding site [chemical binding]; other site 525146006273 Switch I region; other site 525146006274 G2 box; other site 525146006275 G3 box; other site 525146006276 Switch II region; other site 525146006277 G4 box; other site 525146006278 G5 box; other site 525146006279 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 525146006280 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 525146006281 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 525146006282 30S ribosomal protein S7; Validated; Region: PRK05302 525146006283 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 525146006284 S17 interaction site [polypeptide binding]; other site 525146006285 S8 interaction site; other site 525146006286 16S rRNA interaction site [nucleotide binding]; other site 525146006287 streptomycin interaction site [chemical binding]; other site 525146006288 23S rRNA interaction site [nucleotide binding]; other site 525146006289 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 525146006290 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 525146006291 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 525146006292 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 525146006293 active site 525146006294 HIGH motif; other site 525146006295 nucleotide binding site [chemical binding]; other site 525146006296 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 525146006297 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 525146006298 active site 525146006299 KMSKS motif; other site 525146006300 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 525146006301 tRNA binding surface [nucleotide binding]; other site 525146006302 anticodon binding site; other site 525146006303 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 525146006304 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 525146006305 conserved cys residue [active] 525146006306 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 525146006307 lipoyl synthase; Provisional; Region: PRK05481 525146006308 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146006309 FeS/SAM binding site; other site 525146006310 Membrane transport protein; Region: Mem_trans; cl09117 525146006311 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 525146006312 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 525146006313 N-acetyl-D-glucosamine binding site [chemical binding]; other site 525146006314 catalytic residue [active] 525146006315 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 525146006316 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 525146006317 Sulfate transporter family; Region: Sulfate_transp; pfam00916 525146006318 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 525146006319 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 525146006320 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 525146006321 FMN binding site [chemical binding]; other site 525146006322 active site 525146006323 catalytic residues [active] 525146006324 substrate binding site [chemical binding]; other site 525146006325 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 525146006326 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 525146006327 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 525146006328 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 525146006329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146006330 active site 525146006331 phosphorylation site [posttranslational modification] 525146006332 intermolecular recognition site; other site 525146006333 dimerization interface [polypeptide binding]; other site 525146006334 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 525146006335 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 525146006336 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 525146006337 G1 box; other site 525146006338 putative GEF interaction site [polypeptide binding]; other site 525146006339 GTP/Mg2+ binding site [chemical binding]; other site 525146006340 Switch I region; other site 525146006341 G2 box; other site 525146006342 G3 box; other site 525146006343 Switch II region; other site 525146006344 G4 box; other site 525146006345 G5 box; other site 525146006346 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 525146006347 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 525146006348 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 525146006349 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 525146006350 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 525146006351 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525146006352 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 525146006353 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525146006354 active site residue [active] 525146006355 PhosphatidylEthanolamine-Binding Protein (PEBP) domain; Region: PEBP; cl00227 525146006356 substrate binding site [chemical binding]; other site 525146006357 aspartate aminotransferase; Provisional; Region: PRK06836 525146006358 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525146006359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146006360 homodimer interface [polypeptide binding]; other site 525146006361 catalytic residue [active] 525146006362 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 525146006363 active site residue [active] 525146006364 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 525146006365 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 525146006366 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 525146006367 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 525146006368 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 525146006369 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 525146006370 ligand binding site [chemical binding]; other site 525146006371 flexible hinge region; other site 525146006372 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 525146006373 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 525146006374 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 525146006375 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 525146006376 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 525146006377 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 525146006378 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 525146006379 NAD(P) binding site [chemical binding]; other site 525146006380 shikimate binding site; other site 525146006381 Dehydroquinase class II; Region: DHquinase_II; pfam01220 525146006382 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 525146006383 trimer interface [polypeptide binding]; other site 525146006384 active site 525146006385 dimer interface [polypeptide binding]; other site 525146006386 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525146006387 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 525146006388 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 525146006389 Cysteine-rich domain; Region: CCG; pfam02754 525146006390 Cysteine-rich domain; Region: CCG; pfam02754 525146006391 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 525146006392 4Fe-4S binding domain; Region: Fer4_6; pfam12837 525146006393 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 525146006394 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 525146006395 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525146006396 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 525146006397 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 525146006398 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 525146006399 FAD binding pocket [chemical binding]; other site 525146006400 FAD binding motif [chemical binding]; other site 525146006401 phosphate binding motif [ion binding]; other site 525146006402 beta-alpha-beta structure motif; other site 525146006403 NAD binding pocket [chemical binding]; other site 525146006404 Iron coordination center [ion binding]; other site 525146006405 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 525146006406 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 525146006407 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 525146006408 FtsX-like permease family; Region: FtsX; pfam02687 525146006409 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 525146006410 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 525146006411 Walker A/P-loop; other site 525146006412 ATP binding site [chemical binding]; other site 525146006413 Q-loop/lid; other site 525146006414 ABC transporter signature motif; other site 525146006415 Walker B; other site 525146006416 D-loop; other site 525146006417 H-loop/switch region; other site 525146006418 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 525146006419 PLD-like domain; Region: PLDc_2; pfam13091 525146006420 putative active site [active] 525146006421 catalytic site [active] 525146006422 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525146006423 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 525146006424 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 525146006425 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525146006426 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 525146006427 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 525146006428 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 525146006429 Cache domain; Region: Cache_1; pfam02743 525146006430 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 525146006431 dimerization interface [polypeptide binding]; other site 525146006432 PAS domain; Region: PAS_9; pfam13426 525146006433 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146006434 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146006435 dimer interface [polypeptide binding]; other site 525146006436 putative CheW interface [polypeptide binding]; other site 525146006437 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 525146006438 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 525146006439 putative ligand binding site [chemical binding]; other site 525146006440 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525146006441 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 525146006442 TM-ABC transporter signature motif; other site 525146006443 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 525146006444 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 525146006445 TM-ABC transporter signature motif; other site 525146006446 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 525146006447 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 525146006448 Walker A/P-loop; other site 525146006449 ATP binding site [chemical binding]; other site 525146006450 Q-loop/lid; other site 525146006451 ABC transporter signature motif; other site 525146006452 Walker B; other site 525146006453 D-loop; other site 525146006454 H-loop/switch region; other site 525146006455 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 525146006456 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 525146006457 Walker A/P-loop; other site 525146006458 ATP binding site [chemical binding]; other site 525146006459 Q-loop/lid; other site 525146006460 ABC transporter signature motif; other site 525146006461 Walker B; other site 525146006462 D-loop; other site 525146006463 H-loop/switch region; other site 525146006464 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 525146006465 EF-hand domain pair; Region: EF_hand_5; pfam13499 525146006466 Ca2+ binding site [ion binding]; other site 525146006467 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 525146006468 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 525146006469 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 525146006470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525146006471 Coenzyme A binding pocket [chemical binding]; other site 525146006472 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 525146006473 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 525146006474 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 525146006475 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 525146006476 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 525146006477 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 525146006478 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 525146006479 adenosine phosphosulphate reductase, alpha subunit; Region: aprA; TIGR02061 525146006480 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 525146006481 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 525146006482 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 525146006483 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 525146006484 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 525146006485 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 525146006486 dimerization interface [polypeptide binding]; other site 525146006487 active site 525146006488 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 525146006489 Protein export membrane protein; Region: SecD_SecF; cl14618 525146006490 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 525146006491 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 525146006492 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 525146006493 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 525146006494 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 525146006495 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 525146006496 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 525146006497 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 525146006498 homodimer interface [polypeptide binding]; other site 525146006499 substrate-cofactor binding pocket; other site 525146006500 catalytic residue [active] 525146006501 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 525146006502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146006503 Walker A motif; other site 525146006504 ATP binding site [chemical binding]; other site 525146006505 Walker B motif; other site 525146006506 arginine finger; other site 525146006507 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 525146006508 hypothetical protein; Validated; Region: PRK00153 525146006509 recombination protein RecR; Reviewed; Region: recR; PRK00076 525146006510 RecR protein; Region: RecR; pfam02132 525146006511 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 525146006512 putative active site [active] 525146006513 putative metal-binding site [ion binding]; other site 525146006514 tetramer interface [polypeptide binding]; other site 525146006515 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 525146006516 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525146006517 dimerization interface [polypeptide binding]; other site 525146006518 PAS domain; Region: PAS; smart00091 525146006519 PAS domain; Region: PAS_9; pfam13426 525146006520 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146006521 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146006522 dimer interface [polypeptide binding]; other site 525146006523 putative CheW interface [polypeptide binding]; other site 525146006524 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 525146006525 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 525146006526 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 525146006527 nucleotide binding site [chemical binding]; other site 525146006528 NEF interaction site [polypeptide binding]; other site 525146006529 SBD interface [polypeptide binding]; other site 525146006530 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 525146006531 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 525146006532 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 525146006533 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 525146006534 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 525146006535 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 525146006536 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 525146006537 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 525146006538 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 525146006539 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 525146006540 Peptidase family M23; Region: Peptidase_M23; pfam01551 525146006541 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 525146006542 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 525146006543 Ligand Binding Site [chemical binding]; other site 525146006544 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 525146006545 chaperone protein DnaJ; Provisional; Region: PRK14301 525146006546 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 525146006547 HSP70 interaction site [polypeptide binding]; other site 525146006548 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 525146006549 substrate binding site [polypeptide binding]; other site 525146006550 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 525146006551 Zn binding sites [ion binding]; other site 525146006552 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 525146006553 dimer interface [polypeptide binding]; other site 525146006554 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 525146006555 Carbon starvation protein CstA; Region: CstA; pfam02554 525146006556 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 525146006557 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 525146006558 thiS-thiF/thiG interaction site; other site 525146006559 thiazole synthase; Reviewed; Region: thiG; PRK00208 525146006560 phosphate binding site [ion binding]; other site 525146006561 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 525146006562 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146006563 FeS/SAM binding site; other site 525146006564 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 525146006565 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 525146006566 ATP binding site [chemical binding]; other site 525146006567 substrate interface [chemical binding]; other site 525146006568 L-lactate permease; Region: Lactate_perm; cl00701 525146006569 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 525146006570 L-lactate permease; Region: Lactate_perm; cl00701 525146006571 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 525146006572 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 525146006573 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 525146006574 active site 525146006575 Predicted membrane protein [Function unknown]; Region: COG2246 525146006576 GtrA-like protein; Region: GtrA; pfam04138 525146006577 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 525146006578 Ligand binding site; other site 525146006579 Putative Catalytic site; other site 525146006580 DXD motif; other site 525146006581 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 525146006582 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 525146006583 inhibitor-cofactor binding pocket; inhibition site 525146006584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146006585 catalytic residue [active] 525146006586 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 525146006587 putative CheA interaction surface; other site 525146006588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 525146006589 dimer interface [polypeptide binding]; other site 525146006590 phosphorylation site [posttranslational modification] 525146006591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146006592 ATP binding site [chemical binding]; other site 525146006593 Mg2+ binding site [ion binding]; other site 525146006594 G-X-G motif; other site 525146006595 Response regulator receiver domain; Region: Response_reg; pfam00072 525146006596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146006597 active site 525146006598 phosphorylation site [posttranslational modification] 525146006599 intermolecular recognition site; other site 525146006600 dimerization interface [polypeptide binding]; other site 525146006601 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 525146006602 putative binding surface; other site 525146006603 active site 525146006604 cobyric acid synthase; Provisional; Region: PRK00784 525146006605 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525146006606 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 525146006607 catalytic triad [active] 525146006608 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 525146006609 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 525146006610 flagellar motor protein MotA; Validated; Region: PRK09110 525146006611 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 525146006612 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 525146006613 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 525146006614 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 525146006615 ligand binding site [chemical binding]; other site 525146006616 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 525146006617 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 525146006618 ADP binding site [chemical binding]; other site 525146006619 magnesium binding site [ion binding]; other site 525146006620 putative shikimate binding site; other site 525146006621 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 525146006622 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525146006623 active site 525146006624 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 525146006625 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 525146006626 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 525146006627 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 525146006628 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 525146006629 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 525146006630 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 525146006631 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 525146006632 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 525146006633 beta subunit interaction interface [polypeptide binding]; other site 525146006634 Walker A motif; other site 525146006635 ATP binding site [chemical binding]; other site 525146006636 Walker B motif; other site 525146006637 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 525146006638 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 525146006639 core domain interface [polypeptide binding]; other site 525146006640 delta subunit interface [polypeptide binding]; other site 525146006641 epsilon subunit interface [polypeptide binding]; other site 525146006642 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 525146006643 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 525146006644 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 525146006645 alpha subunit interaction interface [polypeptide binding]; other site 525146006646 Walker A motif; other site 525146006647 ATP binding site [chemical binding]; other site 525146006648 Walker B motif; other site 525146006649 inhibitor binding site; inhibition site 525146006650 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 525146006651 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 525146006652 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 525146006653 gamma subunit interface [polypeptide binding]; other site 525146006654 epsilon subunit interface [polypeptide binding]; other site 525146006655 LBP interface [polypeptide binding]; other site 525146006656 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 525146006657 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 525146006658 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 525146006659 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 525146006660 GTP-binding protein LepA; Provisional; Region: PRK05433 525146006661 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 525146006662 G1 box; other site 525146006663 putative GEF interaction site [polypeptide binding]; other site 525146006664 GTP/Mg2+ binding site [chemical binding]; other site 525146006665 Switch I region; other site 525146006666 G2 box; other site 525146006667 G3 box; other site 525146006668 Switch II region; other site 525146006669 G4 box; other site 525146006670 G5 box; other site 525146006671 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 525146006672 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 525146006673 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 525146006674 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 525146006675 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 525146006676 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 525146006677 heat shock protein 90; Provisional; Region: PRK05218 525146006678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146006679 ATP binding site [chemical binding]; other site 525146006680 Mg2+ binding site [ion binding]; other site 525146006681 G-X-G motif; other site 525146006682 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 525146006683 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 525146006684 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 525146006685 active site 525146006686 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 525146006687 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 525146006688 FAD binding pocket [chemical binding]; other site 525146006689 FAD binding motif [chemical binding]; other site 525146006690 phosphate binding motif [ion binding]; other site 525146006691 beta-alpha-beta structure motif; other site 525146006692 NAD binding pocket [chemical binding]; other site 525146006693 Iron coordination center [ion binding]; other site 525146006694 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 525146006695 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 525146006696 heterodimer interface [polypeptide binding]; other site 525146006697 active site 525146006698 FMN binding site [chemical binding]; other site 525146006699 homodimer interface [polypeptide binding]; other site 525146006700 substrate binding site [chemical binding]; other site 525146006701 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 525146006702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 525146006703 NAD(P) binding site [chemical binding]; other site 525146006704 active site 525146006705 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 525146006706 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525146006707 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525146006708 ABC transporter; Region: ABC_tran_2; pfam12848 525146006709 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 525146006710 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 525146006711 active site 525146006712 8-oxo-dGMP binding site [chemical binding]; other site 525146006713 nudix motif; other site 525146006714 metal binding site [ion binding]; metal-binding site 525146006715 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 525146006716 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146006717 FeS/SAM binding site; other site 525146006718 HemN C-terminal domain; Region: HemN_C; pfam06969 525146006719 multifunctional aminopeptidase A; Provisional; Region: PRK00913 525146006720 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 525146006721 interface (dimer of trimers) [polypeptide binding]; other site 525146006722 Substrate-binding/catalytic site; other site 525146006723 Zn-binding sites [ion binding]; other site 525146006724 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 525146006725 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 525146006726 active site 525146006727 SAM binding site [chemical binding]; other site 525146006728 homodimer interface [polypeptide binding]; other site 525146006729 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 525146006730 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 525146006731 active site 525146006732 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 525146006733 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 525146006734 active site 525146006735 substrate binding site [chemical binding]; other site 525146006736 cosubstrate binding site; other site 525146006737 catalytic site [active] 525146006738 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525146006739 active site 525146006740 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 525146006741 active site 525146006742 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 525146006743 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525146006744 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 525146006745 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 525146006746 inhibitor-cofactor binding pocket; inhibition site 525146006747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146006748 catalytic residue [active] 525146006749 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH3; cd08184 525146006750 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 525146006751 putative active site [active] 525146006752 metal binding site [ion binding]; metal-binding site 525146006753 Protein of unknown function (DUF805); Region: DUF805; pfam05656 525146006754 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14184 525146006755 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 525146006756 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 525146006757 homodimer interface [polypeptide binding]; other site 525146006758 NADP binding site [chemical binding]; other site 525146006759 substrate binding site [chemical binding]; other site 525146006760 enolase; Provisional; Region: eno; PRK00077 525146006761 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 525146006762 dimer interface [polypeptide binding]; other site 525146006763 metal binding site [ion binding]; metal-binding site 525146006764 substrate binding pocket [chemical binding]; other site 525146006765 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 525146006766 nucleotide binding site [chemical binding]; other site 525146006767 Type III pantothenate kinase; Region: Pan_kinase; cl17198 525146006768 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 525146006769 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 525146006770 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 525146006771 Ligand binding site; other site 525146006772 Putative Catalytic site; other site 525146006773 DXD motif; other site 525146006774 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 525146006775 Mechanosensitive ion channel; Region: MS_channel; pfam00924 525146006776 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 525146006777 K+ potassium transporter; Region: K_trans; pfam02705 525146006778 Uncharacterized conserved protein [Function unknown]; Region: COG3189 525146006779 putative arabinose transporter; Provisional; Region: PRK03545 525146006780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525146006781 putative substrate translocation pore; other site 525146006782 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525146006783 dimerization interface [polypeptide binding]; other site 525146006784 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 525146006785 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 525146006786 dimer interface [polypeptide binding]; other site 525146006787 putative CheW interface [polypeptide binding]; other site 525146006788 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 525146006789 DNA-binding interface [nucleotide binding]; DNA binding site 525146006790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 525146006791 HTH-like domain; Region: HTH_21; pfam13276 525146006792 Integrase core domain; Region: rve; pfam00665 525146006793 Integrase core domain; Region: rve_3; pfam13683 525146006794 Uncharacterized conserved protein (DUF2290); Region: DUF2290; cl02396 525146006795 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 525146006796 Family description; Region: UvrD_C_2; pfam13538 525146006797 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525146006798 active site 525146006799 DNA binding site [nucleotide binding] 525146006800 Int/Topo IB signature motif; other site 525146006801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525146006802 non-specific DNA binding site [nucleotide binding]; other site 525146006803 salt bridge; other site 525146006804 sequence-specific DNA binding site [nucleotide binding]; other site 525146006805 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 525146006806 active site 525146006807 catalytic residues [active] 525146006808 DNA binding site [nucleotide binding] 525146006809 Int/Topo IB signature motif; other site 525146006810 Helix-turn-helix domain; Region: HTH_17; cl17695 525146006811 CHC2 zinc finger; Region: zf-CHC2; cl17510 525146006812 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 525146006813 active site 525146006814 DNA binding site [nucleotide binding] 525146006815 Int/Topo IB signature motif; other site 525146006816 Restriction endonuclease BamHI; Region: BamHI; pfam02923 525146006817 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 525146006818 DNA methylase; Region: N6_N4_Mtase; pfam01555 525146006819 aspartate aminotransferase; Provisional; Region: PRK05764 525146006820 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525146006821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146006822 homodimer interface [polypeptide binding]; other site 525146006823 catalytic residue [active] 525146006824 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 525146006825 gamma-glutamyl kinase; Provisional; Region: PRK05429 525146006826 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 525146006827 homotetrameric interface [polypeptide binding]; other site 525146006828 putative allosteric binding site; other site 525146006829 nucleotide binding site [chemical binding]; other site 525146006830 PUA domain; Region: PUA; pfam01472 525146006831 GTPase CgtA; Reviewed; Region: obgE; PRK12299 525146006832 GTP1/OBG; Region: GTP1_OBG; pfam01018 525146006833 Obg GTPase; Region: Obg; cd01898 525146006834 G1 box; other site 525146006835 GTP/Mg2+ binding site [chemical binding]; other site 525146006836 Switch I region; other site 525146006837 G2 box; other site 525146006838 G3 box; other site 525146006839 Switch II region; other site 525146006840 G4 box; other site 525146006841 G5 box; other site 525146006842 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 525146006843 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 525146006844 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 525146006845 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 525146006846 TRAM domain; Region: TRAM; pfam01938 525146006847 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 525146006848 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 525146006849 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 525146006850 ATP synthase subunit C; Region: ATP-synt_C; cl00466 525146006851 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 525146006852 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 525146006853 CoA binding domain; Region: CoA_binding; pfam02629 525146006854 cobalamin synthase; Reviewed; Region: cobS; PRK00235 525146006855 FMN binding site [chemical binding]; other site 525146006856 Nitroreductase family; Region: Nitroreductase; pfam00881 525146006857 dimer interface [polypeptide binding]; other site 525146006858 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 525146006859 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525146006860 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146006861 metal binding site [ion binding]; metal-binding site 525146006862 active site 525146006863 I-site; other site 525146006864 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 525146006865 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 525146006866 Probable Catalytic site; other site 525146006867 metal-binding site 525146006868 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 525146006869 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 525146006870 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 525146006871 catalytic triad [active] 525146006872 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 525146006873 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 525146006874 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 525146006875 GDP-binding site [chemical binding]; other site 525146006876 ACT binding site; other site 525146006877 IMP binding site; other site 525146006878 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 525146006879 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 525146006880 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525146006881 substrate binding pocket [chemical binding]; other site 525146006882 membrane-bound complex binding site; other site 525146006883 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 525146006884 substrate binding pocket [chemical binding]; other site 525146006885 membrane-bound complex binding site; other site 525146006886 PAS domain; Region: PAS_9; pfam13426 525146006887 PAS fold; Region: PAS; pfam00989 525146006888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525146006889 putative active site [active] 525146006890 heme pocket [chemical binding]; other site 525146006891 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525146006892 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146006893 metal binding site [ion binding]; metal-binding site 525146006894 active site 525146006895 I-site; other site 525146006896 Methyltransferase domain; Region: Methyltransf_23; pfam13489 525146006897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146006898 S-adenosylmethionine binding site [chemical binding]; other site 525146006899 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 525146006900 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 525146006901 dimerization interface [polypeptide binding]; other site 525146006902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146006903 ATP binding site [chemical binding]; other site 525146006904 Mg2+ binding site [ion binding]; other site 525146006905 G-X-G motif; other site 525146006906 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 525146006907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146006908 active site 525146006909 phosphorylation site [posttranslational modification] 525146006910 intermolecular recognition site; other site 525146006911 dimerization interface [polypeptide binding]; other site 525146006912 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 525146006913 DNA binding site [nucleotide binding] 525146006914 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 525146006915 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 525146006916 putative dimer interface [polypeptide binding]; other site 525146006917 putative anticodon binding site; other site 525146006918 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 525146006919 homodimer interface [polypeptide binding]; other site 525146006920 motif 1; other site 525146006921 motif 2; other site 525146006922 active site 525146006923 motif 3; other site 525146006924 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 525146006925 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 525146006926 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 525146006927 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 525146006928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146006929 catalytic residue [active] 525146006930 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 525146006931 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 525146006932 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 525146006933 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 525146006934 Ligand Binding Site [chemical binding]; other site 525146006935 TIGR00269 family protein; Region: TIGR00269 525146006936 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 525146006937 Flavoprotein; Region: Flavoprotein; pfam02441 525146006938 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 525146006939 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 525146006940 flagellin; Provisional; Region: PRK12804 525146006941 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 525146006942 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 525146006943 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 525146006944 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 525146006945 putative dimer interface [polypeptide binding]; other site 525146006946 flagellin; Provisional; Region: PRK12804 525146006947 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 525146006948 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 525146006949 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 525146006950 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 525146006951 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 525146006952 FeS/SAM binding site; other site 525146006953 PAS fold; Region: PAS_3; pfam08447 525146006954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525146006955 putative active site [active] 525146006956 heme pocket [chemical binding]; other site 525146006957 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146006958 metal binding site [ion binding]; metal-binding site 525146006959 active site 525146006960 I-site; other site 525146006961 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 525146006962 pantoate--beta-alanine ligase; Region: panC; TIGR00018 525146006963 Pantoate-beta-alanine ligase; Region: PanC; cd00560 525146006964 active site 525146006965 ATP-binding site [chemical binding]; other site 525146006966 pantoate-binding site; other site 525146006967 HXXH motif; other site 525146006968 S-adenosylmethionine synthetase; Validated; Region: PRK05250 525146006969 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 525146006970 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 525146006971 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 525146006972 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 525146006973 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 525146006974 Tetramer interface [polypeptide binding]; other site 525146006975 active site 525146006976 FMN-binding site [chemical binding]; other site 525146006977 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 525146006978 AAA domain; Region: AAA_30; pfam13604 525146006979 Family description; Region: UvrD_C_2; pfam13538 525146006980 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 525146006981 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 525146006982 AMMECR1; Region: AMMECR1; pfam01871 525146006983 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 525146006984 Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679 525146006985 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 525146006986 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 525146006987 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 525146006988 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 525146006989 rare lipoprotein A; Region: rlpA; TIGR00413 525146006990 Sporulation related domain; Region: SPOR; pfam05036 525146006991 This domain is found in peptide chain release factors; Region: PCRF; smart00937 525146006992 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 525146006993 RF-1 domain; Region: RF-1; pfam00472 525146006994 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 525146006995 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 525146006996 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 525146006997 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 525146006998 RNA binding surface [nucleotide binding]; other site 525146006999 FtsJ-like methyltransferase; Region: FtsJ; cl17430 525146007000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 525146007001 S-adenosylmethionine binding site [chemical binding]; other site 525146007002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146007003 TPR motif; other site 525146007004 binding surface 525146007005 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 525146007006 seryl-tRNA synthetase; Provisional; Region: PRK05431 525146007007 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 525146007008 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 525146007009 dimer interface [polypeptide binding]; other site 525146007010 active site 525146007011 motif 1; other site 525146007012 motif 2; other site 525146007013 motif 3; other site 525146007014 Uncharacterized conserved protein [Function unknown]; Region: COG1359 525146007015 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 525146007016 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 525146007017 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 525146007018 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 525146007019 surface carbohydrate biosynthesis protein, LIC13510 family; Region: O_ant_LIC13510; TIGR04326 525146007020 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 525146007021 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 525146007022 aminotransferase; Validated; Region: PRK08175 525146007023 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 525146007024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 525146007025 homodimer interface [polypeptide binding]; other site 525146007026 catalytic residue [active] 525146007027 homoserine dehydrogenase; Provisional; Region: PRK06349 525146007028 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 525146007029 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 525146007030 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 525146007031 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 525146007032 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 525146007033 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 525146007034 active site 525146007035 DNA polymerase IV; Validated; Region: PRK02406 525146007036 DNA binding site [nucleotide binding] 525146007037 EVE domain; Region: EVE; pfam01878 525146007038 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 525146007039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146007040 ATP binding site [chemical binding]; other site 525146007041 Mg2+ binding site [ion binding]; other site 525146007042 G-X-G motif; other site 525146007043 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 525146007044 ATP binding site [chemical binding]; other site 525146007045 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 525146007046 AIR carboxylase; Region: AIRC; pfam00731 525146007047 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 525146007048 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 525146007049 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 525146007050 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 525146007051 Family description; Region: VCBS; pfam13517 525146007052 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 525146007053 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 525146007054 Acylphosphatase; Region: Acylphosphatase; pfam00708 525146007055 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 525146007056 HypF finger; Region: zf-HYPF; pfam07503 525146007057 HypF finger; Region: zf-HYPF; pfam07503 525146007058 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 525146007059 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 525146007060 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 525146007061 non-specific DNA binding site [nucleotide binding]; other site 525146007062 salt bridge; other site 525146007063 sequence-specific DNA binding site [nucleotide binding]; other site 525146007064 Cupin domain; Region: Cupin_2; pfam07883 525146007065 AMP-binding domain protein; Validated; Region: PRK08315 525146007066 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525146007067 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 525146007068 acyl-activating enzyme (AAE) consensus motif; other site 525146007069 putative AMP binding site [chemical binding]; other site 525146007070 putative active site [active] 525146007071 putative CoA binding site [chemical binding]; other site 525146007072 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 525146007073 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 525146007074 tandem repeat interface [polypeptide binding]; other site 525146007075 oligomer interface [polypeptide binding]; other site 525146007076 active site residues [active] 525146007077 PAS fold; Region: PAS; pfam00989 525146007078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525146007079 putative active site [active] 525146007080 heme pocket [chemical binding]; other site 525146007081 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525146007082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146007083 metal binding site [ion binding]; metal-binding site 525146007084 active site 525146007085 I-site; other site 525146007086 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 525146007087 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 525146007088 RNA binding site [nucleotide binding]; other site 525146007089 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 525146007090 RNA binding site [nucleotide binding]; other site 525146007091 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 525146007092 RNA binding site [nucleotide binding]; other site 525146007093 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 525146007094 RNA binding site [nucleotide binding]; other site 525146007095 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 525146007096 RNA binding site [nucleotide binding]; other site 525146007097 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 525146007098 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 525146007099 active site 525146007100 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 525146007101 active site 525146007102 N-terminal domain interface [polypeptide binding]; other site 525146007103 YheO-like PAS domain; Region: PAS_6; pfam08348 525146007104 HTH domain; Region: HTH_22; pfam13309 525146007105 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 525146007106 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 525146007107 acyl-activating enzyme (AAE) consensus motif; other site 525146007108 AMP binding site [chemical binding]; other site 525146007109 active site 525146007110 CoA binding site [chemical binding]; other site 525146007111 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 525146007112 active site 525146007113 homotetramer interface [polypeptide binding]; other site 525146007114 homodimer interface [polypeptide binding]; other site 525146007115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 525146007116 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 525146007117 Coenzyme A binding pocket [chemical binding]; other site 525146007118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 525146007119 Major Facilitator Superfamily; Region: MFS_1; pfam07690 525146007120 putative substrate translocation pore; other site 525146007121 BCCT family transporter; Region: BCCT; pfam02028 525146007122 Uncharacterized conserved protein [Function unknown]; Region: COG3379 525146007123 Uncharacterized conserved protein [Function unknown]; Region: COG3379 525146007124 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 525146007125 PAS fold; Region: PAS_3; pfam08447 525146007126 putative active site [active] 525146007127 heme pocket [chemical binding]; other site 525146007128 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 525146007129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146007130 Walker A motif; other site 525146007131 ATP binding site [chemical binding]; other site 525146007132 Walker B motif; other site 525146007133 arginine finger; other site 525146007134 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525146007135 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 525146007136 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 525146007137 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 525146007138 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 525146007139 lipoyl attachment site [posttranslational modification]; other site 525146007140 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 525146007141 EamA-like transporter family; Region: EamA; pfam00892 525146007142 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 525146007143 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 525146007144 putative active site [active] 525146007145 putative NTP binding site [chemical binding]; other site 525146007146 putative nucleic acid binding site [nucleotide binding]; other site 525146007147 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 525146007148 HTH-like domain; Region: HTH_21; pfam13276 525146007149 Integrase core domain; Region: rve; pfam00665 525146007150 Integrase core domain; Region: rve_3; pfam13683 525146007151 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 525146007152 DNA-binding interface [nucleotide binding]; DNA binding site 525146007153 Predicted transcriptional regulator [Transcription]; Region: COG2944 525146007154 Fic family protein [Function unknown]; Region: COG3177 525146007155 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 525146007156 Fic/DOC family; Region: Fic; pfam02661 525146007157 Fic family protein [Function unknown]; Region: COG3177 525146007158 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 525146007159 Fic/DOC family; Region: Fic; pfam02661 525146007160 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 525146007161 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 525146007162 active site 525146007163 catalytic residues [active] 525146007164 DNA binding site [nucleotide binding] 525146007165 Int/Topo IB signature motif; other site 525146007166 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 525146007167 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 525146007168 putative active site [active] 525146007169 catalytic site [active] 525146007170 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 525146007171 putative active site [active] 525146007172 catalytic site [active] 525146007173 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 525146007174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 525146007175 ATP binding site [chemical binding]; other site 525146007176 Mg2+ binding site [ion binding]; other site 525146007177 G-X-G motif; other site 525146007178 TPR repeat; Region: TPR_11; pfam13414 525146007179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 525146007180 binding surface 525146007181 TPR motif; other site 525146007182 TPR repeat; Region: TPR_11; pfam13414 525146007183 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 525146007184 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 525146007185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 525146007186 Walker A/P-loop; other site 525146007187 ATP binding site [chemical binding]; other site 525146007188 Q-loop/lid; other site 525146007189 ABC transporter signature motif; other site 525146007190 Walker B; other site 525146007191 D-loop; other site 525146007192 H-loop/switch region; other site 525146007193 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 525146007194 CcmE; Region: CcmE; cl00994 525146007195 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 525146007196 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 525146007197 metal binding site [ion binding]; metal-binding site 525146007198 active site 525146007199 I-site; other site 525146007200 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 525146007201 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 525146007202 glutaminase active site [active] 525146007203 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 525146007204 dimer interface [polypeptide binding]; other site 525146007205 active site 525146007206 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 525146007207 dimer interface [polypeptide binding]; other site 525146007208 active site 525146007209 periplasmic folding chaperone; Provisional; Region: PRK10788 525146007210 SurA N-terminal domain; Region: SurA_N_3; cl07813 525146007211 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 525146007212 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 525146007213 GAF domain; Region: GAF; pfam01590 525146007214 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525146007215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146007216 Walker A motif; other site 525146007217 ATP binding site [chemical binding]; other site 525146007218 Walker B motif; other site 525146007219 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525146007220 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 525146007221 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 525146007222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 525146007223 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 525146007224 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 525146007225 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 525146007226 hypothetical protein; Validated; Region: PRK06201 525146007227 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 525146007228 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 525146007229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 525146007230 active site 525146007231 phosphorylation site [posttranslational modification] 525146007232 intermolecular recognition site; other site 525146007233 dimerization interface [polypeptide binding]; other site 525146007234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 525146007235 Walker A motif; other site 525146007236 ATP binding site [chemical binding]; other site 525146007237 Walker B motif; other site 525146007238 arginine finger; other site 525146007239 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 525146007240 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 525146007241 AIR carboxylase; Region: AIRC; smart01001